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  • 1985-1989  (717)
  • 1988  (717)
  • Engineering General  (570)
  • Genetics  (147)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 147 (1988), S. 550-552 
    ISSN: 1432-1076
    Keywords: Pterygium syndrome ; Congenital malformations ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present two brothers with Multiple Pterygium Syndrome type Escobar. Characteristic findings in this autosomal recessively inherited pterygium syndrome are, in addition to multiple pterygia, short stature, cleft palate, vertebral fusion defects and minor facial anomalies. The adult height in the two male siblings was below the third centile. Secondary sexual development and testicular size were normal, in contrast with the cryptorchidism and pubertal delay documented in most young patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Genetics ; Type 2 (non-insulin-dependent) diabetes ; insulin receptor ; linkage analysis ; maturity onset diabetes of the young
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restriction enzyme digests of genomic DNA from all available family members. The digested DNA was subjected to agarose gel electrophoresis, Southern blotted, and hybridised to 32P-labelled human insulin receptor gene cDNA. In the pedigree with maturity onset diabetes of the young, formal linkage analysis allowed exclusion of close linkage between the insulin receptor locus and diabetes (logarithm of the odds for linkage versus non-linkage was −5.35 at recombination fraction of 0.01). This confirms the absence of linkage between insulin receptor and diabetes which has been reported in two similar pedigrees. In the three Type 2 diabetic families there were a minimum of 4 recombinants between the insulin receptor locus and diabetes, which makes a direct role for insulin receptor defects unlikely. The importance of using realistic estimates of penetrance when performing linkage analysis in a disease with a late age of onset is emphasised. In contrast to the one previous linkage analysis study of the insulin receptor gene, no specific association of diabetes with the rare Sstl Sl(-) allele was observed in either the maturity onset diabetes of the young or the Type 2 diabetic families.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 31 (1988), S. 407-414 
    ISSN: 1432-0428
    Keywords: Genetics ; Type 2 (non-insulin-dependent) diabetes ; linkage analysis ; restriction fragment length polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the last five years, genetic markers for a large number of diseases have been localised using linkage analysis of DNA polymorphisms in affected families. The site of the genetic defect or defects leading to Type 2 (non-insulin-dependent) diabetes mellitus, a common illness with a major genetic component, remains unknown. This is due, at least in part, to the lack of large well-defined Type 2 diabetic pedigrees suitable for linkage analysis. There are several features of the disease which make large pedigrees difficult to find. The late age of onset of most probands means that informative older generations are often dead, while there is difficulty in detecting disease in younger generations. The diagnostic criteria for diabetes are, as yet, dependent on an arbitrary cut-off along a continuum of plasma glucose. The high prevalence of the disease may also produce problems as, in any given family, diabetogenic genes may be contributed by more than one parent. Varieties of the disease with a well-defined inheritance, such as maturity onset diabetes of youth, are more suitable for linkage analysis but might be due to defects at a different gene locus. Despite these difficulties, once large well-defined pedigrees have been found, linkage analysis using both candidate genes and random highly polymorphic markers is the strategy most likely to find genetic markers for the disease.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 237 (1988), S. 244-252 
    ISSN: 1433-8491
    Keywords: EEG ; Genetics ; MZ/DZ twins reared apart ; Within-pair similarity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Within the broader context of our investigations into the heredity of the human EEG, we analysed the EEGs of 28 pairs of monozygotic and 21 pairs of dizygotic twins who were separated as infants and reared apart. The principal goal of this study was to determine the degree to which environmental factors possibly influence the development of a person's EEG. Monozygotic twins reared apart were, with respect to their EEGs, only slightly less similar to each other (if there is any difference at all) than the same person is to himself over time. For dizygotic twins reared apart, we verified the findings of our previous study, namely, that the average within-pair similarity of EEGs estimated from a sufficiently representative sample of fraternal twins was significantly higher than the average inter-individual similarity of EEGs obtained from unrelated persons. The results on both monozygotic and dizygotic twins, yielded conclusive proof that the individual EEG pattern is predominantly determined by hereditary factors.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1988), S. 366-367 
    ISSN: 1432-1459
    Keywords: Gilles de la Tourette's syndrome ; Twin study ; Computed tomography ; Clinical neurophysiology ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 19-year-old male twin pair were concordant for suffering from Gilles de la Tourette's syndrome in different forms and severity. CT revealed ventricular asymmetries of varying degree within the normal range and there were no neurophysiological abnormalities. The interrelationship of genetic and environmental factors in phenotyping the syndrome is discussed.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1988), S. 422-424 
    ISSN: 1432-1459
    Keywords: Epidemiology ; Genetics ; Hereditary motor neuropathy ; Spinal muscular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 4-year-search for spinal muscular atrophies (hereditary motor neuropathies, HMN) in Benghazi, Libya, yielded a total of 24 patients, among whom 18 were index cases. This group comprised 6 acute infantile, 12 chronic childhood, and 3 each with adult-onset proximal, and distal forms of the disorder. Distal HMN constituted 12.5% of the total cases. The crude average annual incidence of acute infantile HMN was 0.3/100,000 total population and 1/12,500 births in Benghazi. The crude prevalence rates of chronic childhood, adult-onset proximal, and distal types of HMN were 2.3, 0.6, and 0.6/100,000 respectively. The segregation ratios, 0.26 for acute infantile HMN and 0.24 for chronic childhood HMN, suggested autosomal recessive inheritance. The consanguinity rates among parents of cases and the population did not differ significantly.
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  • 7
    ISSN: 1432-1440
    Keywords: Genetics ; Hepatitis-B virus ; Immunogenetics ; Vaccination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The variation in immune responses to standard inoculation of the hepatitis-B virus vaccine suggest that host factors influence response in ways that are not presently understood. We studied 25 low/nonresponding health care workers (anti-HBs titer 〈50 IU/l) after the third inoculation of an experimental hepatitis-B vaccine to determine their immune status (through lymphocyte phenotypes) and HLA type. After application of a fourth inoculation, the seroconverting subjects showed only low anti-HBs levels; three male subjects remained anti-HBs negative. Twelve months after the fourth inoculation only 9 of 25 subjects (36%) maintained anti-HBs titer 〉10 IU/l. Almost all subjects had normal B-cell and CD-4 and CD-8 counts and ratios. Relative to other European populations HLA-A-10 (P〈0.05), B-12 (P〈0.025), CW-5 (P〈0.05), DR-3 (P〈0.025), and DR-5 (P〈0.025) were increased, whereas DR-2 (P〈0.05) was decreased. However, after correction of theP-values for the number of HLA antigens determined, these differences were no longer significant. Furthermore, these HLA types were not the same as those reported in other studies (except for DR-3). We suggest that larger sample sizes or even not yet available immunogenetic markers will be required to prove an “immunogenetic background” in low/nonresponders, if it exists.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 95 (1988), S. 237-244 
    ISSN: 1432-2072
    Keywords: Morphine ; Etonitazene ; Genetics ; Mice ; Taste ; Saccharine ; Gender
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract C57BL/6J and DBA/2J mouse strains have been characterized as morphine preferrers and avoiders, respectively (Horowitz et al. 1977). Previously, sweetened morphine solutions were presented with a water alternative, primarily with male subjects. Because sweetness may affect the endogenous opioid system and rodents have shown strain and sex differences in taste preferences, this study looked for strain- and gender-related taste preferences that might have affected opiate consumption. Preference for sweetened and unsweetened morphine and etonitazene was compared across gender and strain. In all choice tests, the control was a similar tasting quinine sulphate solution. Under these conditions, C57BL/6J mice continued to show strong preference for morphine. However, DBA/2J mice drank approximately equal amounts of morphine and quinine solutions, rather than avoiding morphine as when water was the alternative. Both strains appeared surprisingly indifferent to the synthetic opioid etonitazene, compared because it is potent at concentrations having barely perceptible bitterness. This raises the possibility of unexpected differences in post-ingestional effects between morphine and etonitazene. Contrary to reports of gender differences in sweet preference in rats, none were found in either strain of mouse. Neither were there any significant sex differences in opiate preference in either strain. C57 mice preferred sweetness more than did DBA mice.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 2 (1988), S. 239-243 
    ISSN: 1432-198X
    Keywords: Cockayne syndrome ; Renal histology ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two siblings with typical features of the Cockayne syndrome were studied at autopsy. Many glomeruli revealed a paucity of capillary loops and had thickened capillary walls. Some glomeruli with advanced lesions showed collapse of the glomerular tufts or complete hyalinization. Atrophy of tubules and interstitial fibrosis were also observed. There were no significant arteriosclerotic changes in the vessels. Ultrastructural studies demonstrated thickened glomerular basement membranes with bends and folds. These histopathological findings are different to those previously reported with the exception of the 1966 report by Ohno and Hirooka.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2242
    Keywords: Ornithine decarboxylase ; Chicken ; Muscle ; Genetics ; Growth differences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Little is known about the biochemical correlates of selection for growth in farm or laboratory animals, or the identity of the gene products affected or produced by ‘trait-genes’. Modern broiler chickens have about 8-fold greater breast muscle mass than layer chickens at 7 weeks of age and over 2-fold greater breast muscle mass than their 1972 counterparts. This increase in muscle mass is associated with over 20-fold higher levels of ornithine decarboxylase (ODC) in broiler chickens at 1 week of age as compared with layer strain chickens; there is a comparable increase in a relaxed-selection strain of broilers. The increase in ODC levels is larger than the differences in muscle or body weight between broilers and layers at 7 weeks of age, occurs at an age when there is no difference in weights between the strains and precedes the major growth spurt. Increases in ODC levels and hence polyamine synthesis have been associated with, and usually precede, rapid growth and cell proliferation in a wide range of cell types and organisms in response to many different stimuli. Therefore, the correlation of ODC levels with genetic differences in muscle growth make it worth investigating the control of ODC gene expression in these strains.
    Type of Medium: Electronic Resource
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  • 11
    ISSN: 1432-2242
    Keywords: Taxonomy ; Germplasm identification ; Varietal identity ; Environmental interaction ; Genetics ; Multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Separations of kafirin and alcohol soluble glutelin proteins by reversed-phase high-performance liquid chromatography (RP-HPLC) from 7 inbreds and one hybrid of sorghum [Sorghum bicolor (L.) Moench] and one source of Johnsongrass [Sorghum halapense (L.) Pers.] were compared. Objectives were to assess the stability of protein profiles for seed sources produced at different locations and in different environments to examine the potential of RP-HPLC to provide genotypic profiles for sorghum. Analyses of variance data showed that levels of variation due to environments and locations were small; the majority of variation (93%) was among genotypes. Associations among inbreds revealed by multivariate and cluster analysis showed similarity with those that would be expected on the basis of pedigree. A chi-square analysis showed no deviation in the hybrid profile from the expected 2∶1 ratio of peaks from the female and male inbred parents, respectively. Improvements in the ability to correctly assign common peaks are necessary before associations among numerous sorghum genotypes can be reliably demonstrated by analysis of data from reversed-phase high-performance liquid chromatography (RP-HPLC).
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 76 (1988), S. 405-410 
    ISSN: 1432-2242
    Keywords: Zea mays ; Haploid induction ; Gynogenesis ; Genetics ; Inducer line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effect of genotype on maternal haploid plant production in maize was studied. The frequency of gynogenetic plants when “Stock 6” was used as pollinator varied according to the female parent genotype. No simple relation was observed between genotypic aptitudes for gynogenetic and androgenetic development, which occured after pollination of “W23” plant carrying the “indeterminate gametophyte” gene. Furthermore, the population NS, a favorably responsive genotype to anther culture, does not exhibit exceptional ability for in vivo gynogenesis. The effect of inbreeding and the influence of maternal haploid origin suggest that specific genes control maternal haploid initiation and development. However, gynogenetic development is not limited to a particular genotype. The frequency of maternal haploids may be increased by using specific pollen parents. Attempts were made to select for a high haploidyinducing trait and the present study reports the successful development of lines that can be utilized as pollen parents to induce haploids for experimental purposes and breeding programmes. When an inbred line “WS14”, derived from the cross W23 x Stock 6, was used as pollen parent, 2%–5% maternal haploids were obtained according to the female parent genotype. A high haploidy-inducing potential is a heritable trait and may be controlled by a limited number of genes. Genetic determination of the haploidy-inducing character was examined in relation to the efficiency of the selecting method and the mechanisms involved in the origin of maternal haploids.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 94 (1988), S. 428-430 
    ISSN: 1432-2072
    Keywords: Lithium ; Clonidine ; alpha2-Adrenoceptor ; Locomotor activity ; Genetics ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four strains of mice (C57, BALB, DBA, C3H) were used to determine whether genetic factors influence the effects of lithium on hypoactivity induced by a low dose of the alpha2-adrenoceptor agonist clonidine (0.2 mg/kg). Lithium was administered in the diet for 3–4 weeks at a dosage that produced average serum lithium levels of 0.58–0.66 mmol/l. Locomotor activity was reduced by either clonidine or by lithium given alone. When combined, however, lithium attenuated the activity-suppressant effects of clonidine, and that action was influenced by genetic factors. The findings suggest that genetic differences in alpha2-adrenoceptors play a role in behavioural effects of lithium.
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-2072
    Keywords: Selective breeding ; Mouse ; Ethanol-stimulated activity ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low doses of ethanol (EtOH) stimulate activity in an open field in many strains of laboratory mice. We are selectively breeding two lines of mice to exhibit a large (FAST) response on this test, and two other lines to exhibit a small (SLOW) response (Crabbe et al. 1987). The lines initially diverged in response to EtOH, but despite continued selection pressure, the difference between each pair of FAST and SLOW lines has not increased over generations as much as expected. Our practice has been to test animals on the 1st day after saline injection, and repeat the test after EtOH injection 24 h later. Lister (1987) recently demonstrated that the order in which an animal was exposed to EtOH and saline influenced the magnitude of the response to EtOH, with animals tested initially after EtOH having greater stimulation. Middaugh et al. (1987) recently demonstrated that the magnitude of EtOH stimulation was greater under conditions of relatively bright light than under dim light. Using non-selected Swiss mice, the current experiments essentially confirmed Lister's findings. Using FAST and SLOW mice, the predictions of both groups were tested. Both hypotheses were confirmed. Additionally, these experiments demonstrated that the magnitude of the difference between FAST and SLOW mice was greater under bright light than under dim light. The line difference was also greater when tested in the EtOH-Saline order. In experiments with Swiss mice, the possible role of peritoneal irritation in the EtOH effect was eliminated, and the optimal dose and time for demonstrating the effect was determined. These experiments confirm the importance of lighting condition, order of testing, dose, and route of administration in eliciting EtOH-stimulated open field activity in mice. They demonstrate a genotype-environment interaction, since the magnitude of difference between genetically selected lines varied as a function of the testing parameters chosen. Finally, they indicate that the differences between FAST and SLOW lines in sensitivity to EtOH generalizes to several environmental conditions. We interpret this to mean that the various EtOH-induced activation traits represented by these different environmental and testing conditions are genetically correlated.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 75 (1988), S. 889-901 
    ISSN: 1432-2242
    Keywords: Soybean ; Restriction fragment length polymorphism ; Genetics ; Allele ; Variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Restriction Fragment Length Polymorphisms (RFLP) have been identified between widely distant cultivars (‘Minsoy’ and ‘Noir 1 ’) of soybean Glycine max (L.) Merrill. Using as probes randomly chosen clones of DNA, one in five probes revealed a polymorphism. More than half of these polymorphisms appear to result from rearrangements of the genomic DNA. Twenty seven markers were analyzed for linkage in F2 plants. Eleven of these markers were contained in four linkage groups. Five cultivars were compared in a search for new alleles. When RFLP markers corresponding to low copy DNA were used to analyze three other cultivars — ‘Sooty’, ‘Forrest’ and ‘Mandarin (Ottawa)’ — few new alleles were found. Using these probes, five different markers could be used to differentiate the five cultivars. Complex probes, which correspond to repeated DNA, revealed different polymorphisms in different cultivars and a single such probe could be used to distinguish the five cultivars from each other.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 491-495 
    ISSN: 1420-9071
    Keywords: Genetics ; stress ; emotionality ; locus ceruleus ; Maudsley strains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The Maudsley Reactive and Non-Reactive strains have been developed as a model for the study of individual variations in stress-reactivity, and many differences in biobehavioral systems have been found between them. This review discusses limitations of the ‘emotionality’ construct in accounting for differences between the Maudsley strains and offers an alternative, theoretical approach. Amaral and Sinnamon have proposed that the locus ceruleus (LC) plays a stress-attenuating role in mediating behavioral, physiological and neuroendocrine response to prepotent, emergency-provoking stimuli and, building upon this formulation, it is proposed that the LC has been an important focus for gene action in the Maudsley model. It is suggested that the LC of the Non-Reactive strain is more strongly activated by stressful stimuli than the LC of Reactive rats, and is the basis of many of the behavioral and physiological differences between them. Behavioral and biochemical evidence consistent with this proposition is reviewed. Identification of the LC as a target for gene-action in the Maudsley model has an important advantage. It substitutes variations at a specific anatomic location in the brain for a loosely defined construct like emotionality, and the hypothesis is amenable to empirical tests by a variety of experimental approaches.
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  • 17
    ISSN: 0032-8332
    Keywords: Saimiri ; Human-type ABO blood groups ; Genetics ; Colony management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The human-type ABO blood groups were determined for 94 families of the squirrel monkey which included 151 animals. Four phenotypes of ABO blood groups (A, B, AB, and O) were detected. Family analysis revealed that the human-type ABO blood groups in this species were governed by three alleles, codominantA andB and silentO. There were intraspecific differences in the distribution of phenotypes and gene frequency among three populations imported by different routes at different times. The usefulness of ABO blood groups for defining the genetic variability of a squirrel monkey breeding colony through successive generations is discussed on the basis of the difference in distribution of ABO blood groups between wild-originated parental and its first colony-born populations.
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  • 18
    ISSN: 1617-4623
    Keywords: Nicotiana plumbaginifolia ; Nitrate reductase ; Genetics ; Molybdenum cofactor biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A total of 70 cnx mutants have been characterized from a collection of 211 nitrate reductase deficient (NR-) mutants isolated from mutagenized Nicotiana plumbaginifolia protoplast cultures after chlorate selection and regeneration into plants. They are presumed to be affected in the biosynthesis of the molybdenum cofactor since they are also deficient for xanthine dehydrogenase activity but contain NR apoenzyme. The remaining clones were classified as nia mutants. Sexual crosses performed between cnx mutants allowed them to be classified into six independent complementation groups. Mutants representative of these complementation groups were used for somatic hybridization experiments with the already characterized N. plumbaginifolia mutants NX1, NX24, NX23 and CNX103 belonging to the complementation groups cnxA, B, C and D respectively. On the basis of genetic analysis and somatic hybridization experiments, two new complementation groups, cnxE and F, not previously described in higher plants, were characterized. Unphysiologically high levels of molybdate can restore the NR activity of cnxA mutant seedlings in vivo, but cannot restore NR activity to any mutant from the other cnx complementation groups.
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  • 19
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 20
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 659-669 
    ISSN: 0271-2091
    Keywords: Magnetohydrodynamics ; Homotopy ; Quasi-Newton ; Rotating disk ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper studies the effects of a circular magnetic field on the flow of a conducting fluid about a porous rotating disk. Using modern quasi-Newton and globally convergent homotopy methods, numerical solutions are obtained for a wide range of magnetic field strengths, suction and injection velocities and Alfven and disk speeds. Results are presented graphically in terms of three non-dimensional parameters. There is excellent agreement with previous work and asymptotic formulae.
    Additional Material: 3 Ill.
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  • 21
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    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 671-686 
    ISSN: 0271-2091
    Keywords: Multigrid ; Pressure correction ; Navier-Stokes ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The behaviour of the pressure correction method is studied for the solution of the incompressible steady-state Navier-Stokes and continuity equations in a rotating cylindrical-polar co-ordinate system, the specific problem being that of laminar source-sink flow between two corotating discs. Modifications to improve the linearization and the handling of the rotation terms are introduced, and we compare three extended pressure correction schemes and also the use of a multigrid algorithm in part of the calculation procedure as a linear solver.
    Additional Material: 1 Ill.
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  • 22
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 965-975 
    ISSN: 0271-2091
    Keywords: Finite element method ; Turbulent flow ; Method of characteristics ; Penalty function approach ; Galerkin method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A finite element technique is presented and applied to some one- and two-dimensional turbulent flow problems. The basic equations are the Reynolds averaged momentum equations in conjunction with a two-equation (k, ∊) turbulence model. The equations are written in time-dependent form and stationary problems are solved by a time iteration procedure. The advection parts of the equations are treated by the use of a method of characteristics, while the continuity requirement is satisfied by a penalty function approach. The general numerical formulation is based on Galerkin's method. Computational results are presented for one-dimensional steady-state and oscillatory channel flow problems and for steady-state flow over a two-dimensional backward-facing step.
    Additional Material: 8 Ill.
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  • 23
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 989-990 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 24
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 991-994 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 25
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1029-1036 
    ISSN: 0271-2091
    Keywords: Incompressible Flow ; Pressure Poisson Equation ; Inviscid Flow ; Boundary Conditions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In a recent paper Gresho and Sani showed that Dirichlet and Neumann boundary conditions for the pressure Poisson equation give the same solution. The purpose of this paper is to confirm this (for one case at least) by numerically solving the pressure equation with Dirichlet and Neumann boundary conditions for the inviscid stagnation point flow problem. The Dirichlet boundary condition is obtained by integrating the tangential component of the momentum equation along the boundary. The Neumann boundary condition is obtained by applying the normal component of the momentum equation at the boundary. In this work solutions for the Neumann problem exist only if a compatibility condition is satisfied. A consistent finite difference procedure which satisfies this condition on non-staggered grids is used for the solution of the pressure equation with Neumann conditions. Two test cases are computed. In the first case the velocity field is given from the analytical solution and the pressure is recovered from the solution of the associated Poisson equation. The computed results are identical for both Dirichlet and Neumann boundary conditions. However, the Dirichlet problem converges faster than the Neumann case. In the second test case the velocity field is computed from the momentum equations, which are solved iteratively with the pressure Poisson equation. In this case the Neumann problem converges faster than the Dirichlet problem.
    Additional Material: 5 Ill.
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  • 26
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1117-1118 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 27
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1107-1116 
    ISSN: 0271-2091
    Keywords: Numerical Stability ; Eddy Viscosity ; LES ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In a spectral LES code it is not possible to treat the actual eddy viscosity implicitly. We have therefore examined the effect on stability of adding a constant pseudo-viscosity to the implicit term and subtracting it from the explicit term: stability limits have been derived theoretically and verified computationally for two different treatments of the explicit term. We have also studied the effect of a stochastic temporal variation of the eddy viscosity.
    Additional Material: 7 Ill.
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  • 28
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1135-1149 
    ISSN: 0271-2091
    Keywords: Three-dimensional unstructured grids ; Advancing-front technique ; Grid generation ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The generation of three-dimensional unstructured grids using the advancing-front technique is described. This technique has been shown to be effective for the generation of unstructured grids in two dimensions.1,2 However, its extension to three-dimensional regions required algorithms to define the surface and suitable data structures that avoid excessive CPU-time overheads for the search operations involved. After obtaining an initial triangulation of the surfaces, tetrahedra are generated by successively deleting faces from the generation front. Details of the grid generation algorithm are given, together with examples and timings.
    Additional Material: 11 Ill.
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  • 29
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1183-1193 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The different stages of bursting and evolution of the fluctuation field in a turbulent boundary layer are governed by mechanisms that may be identified as either predominantly linear, i.e. governed by linear interaction with the mean shear flow, or non-linear, i.e. with interaction between the fluctuation components also being important. Wave number-frequency spectra reveal the presence of damped wave modes that may be modelled from the Orr-Sommerfeld equation. Conditional sampled experimental data for streamwise velocity fluctuations in the wall layer obtained using the variable interval time averaging (VITA) method scale with the threshold level in a manner consistent with linearity. High-amplitude wall pressure peaks show an approximately linear relationship with the associated vertical velocity fluctuations. Non-linearity acts primarily in the near-wall region where the fluctuation velocity is relatively the highest.
    Additional Material: 6 Ill.
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  • 30
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1367-1388 
    ISSN: 0271-2091
    Keywords: Laminar boundary layer ; Splines Incompressible ; Inverse and direct methods ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A unified approach is presented for solving the two-dimensional incompressible boundary layer equations. Solutions are obtained for direct and inverse options using the same equation formulation by a simple interchange of boundary conditions. A modified form of the mechul function scheme obtains inverse solutions with specification of transformed wall shear, skin friction coefficient or displacement thickness distributions. Direct solutions may be obtained without altering the block tridiagonal structure of the system by simply requiring no corrections on the streamwise pressure gradient parameter. Fourth-order spline discretization approximates normal derivatives with two- and three-point backward differences approximating streamwise derivatives, yielding a fully implicit solution method. The resulting spline/finite difference equations are solved by Newton-Raphson iteration together with partial pivoting. The results of the study demonstrate the importance of proper linearization of all equations. The successful use of spline discretization is also tied to the use of strong two-point boundary conditions at the wall for cases involving reversed flow. Numerical solutions are presented for several non-similar flows and compared with published results.
    Additional Material: 8 Ill.
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  • 31
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988), S. 1389-1401 
    ISSN: 0271-2091
    Keywords: Non-Newtonian fluid interfaces ; Porous media ; Frontal advance theory ; Power law behaviour ; Oil displacement mechanisms ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper concerns the applications of frontal advance theory to the dynamics of a moving flat interface in a porous medium, when both displacing and displaced fluids are of power law behaviour. The rheological effects of non-Newtonian behaviour of these fluids on the interface position and its velocity are numerically illustrated and discussed with regard to the practical implications in oil displacement mechanisms. The results obtained should be useful in finding an optimal policy of injection in order to control the dynamics of the moving interface in field projects of enhanced oil recovery floods.
    Additional Material: 5 Ill.
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  • 32
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1465-1466 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 33
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 34
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1587-1588 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 35
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1563-1586 
    ISSN: 0271-2091
    Keywords: Finite element ; Turbulence model ; Free shear flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper reviews past and current efforts in developing a simple but robust turbulence model for free shear flows. Much of this work has been published previously and this paper is a rearrangement aimed at the conference. The model is presented and is interfaced with FIDAP to solve three-dimensional flows and a pusher - prop configuration. The eight-node brick, the penalty formulation and the Broyden method are used to solve the Navier-Stokes equations. The propeller is modelled as an actuator disc and the direct simulation of a given propeller is considered in detail. Good results are obtained for the square jet. For propeller cases detailed comparison with wind tunnel measurements shows excellent prediction of the velocity and pressure for flows of this complexity.
    Additional Material: 17 Ill.
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  • 36
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1523-1541 
    ISSN: 0271-2091
    Keywords: Heat exchanger ; Three-dimensional flow ; Finite elements ; FIDAP ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The finite element code FIDAP was used to examine the fluid flow path within a flat plate tube/fin heat exchanger and the resulting heat transfer from the fins and tube walls. The mathematical formulation, mesh development and analysis procedure are presented, and the results obtained are compared with experimental observations of the fluid flow and measurements of the fluid heating. This problem illustrates the capabilities of finite element techniques for analysing complex three-dimensional convection-dominated heat transfer, and demonstrates the scope of problems which can be addressed on a Micro VAX II/GPX workstation.
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  • 37
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1588-1588 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 38
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 39
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    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 40
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 247-281 
    ISSN: 0271-2091
    Keywords: Natural convection ; Finite element method ; High Rayleigh number ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Finite element predictions of two-dimensional laminar natural convection in a partially divided rectangular cavity at high Rayleigh number are presented. The walls are differentially heated, the horizontal surfaces are insulated and the cavity contains a partial vertical divider which is centrally located and whose height is varied. Detailed results are presented for an aluminium half-divider in water for Rayleigh number up to 1011 and compared directly with recent experiments in a cavity of aspect ratio 1/2. The predicted flow and heat transfer are in good agreement with the measurements and confirm the existence of a high Rayleigh number regime with characteristic behaviour that differs significantly from that found at lower Rayleigh number. In addition, the effects of the divider height, the divider conductivity, the fluid Prandtl number and the cavity aspect ratio are studied. The results show that a direct simulation of the complex flow and heat transfer that occurs in partially divided cavities is possible for realistic physical conditions.
    Additional Material: 18 Ill.
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  • 41
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 475-489 
    ISSN: 0271-2091
    Keywords: Adaptive grid computation ; High Reynolds number flow ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Recently the concept of adaptive grid computation has received much attention in the computational fluid dynamics research community. This paper continues the previous efforts of multiple one-dimensional procedures in developing and asessing the ideas of adaptive grid computation. The focus points here are the issue of numerical stability induced by the grid distribution and the accuracy comparison with previously reported work. Two two-dimensional problems with complicated characteristics - namely, flow in a channel with a sudden expansion and natural convection in an enclosed square cavity - are used to demonstrate some salient features of the adaptive grid method. For the channel flow, by appropriate distribution of the grid points the numerical algorithm can more effectively dampen out the instabilities, especially those related to artificial boundary treatments, and hence can converge to a steady-state solution more rapidly. For a more accurate finite difference operator, which contains less undesirable numerical diffusion, the present adaptive grid method can yield a steady-state and convergent solution, while uniform grids produce non-convergent and numerically oscillating solutions. Furthermore, the grid distribution resulting from the adaptive procedure is very responsive to the different characteristics of laminar and turbulent flows. For the problem of natural convection, a combination of a multiple one-dimensional adaptive procedure and a variational formulation is found very useful. Comparisons of the solutions on uniform and adaptive grids with the reported benchmark calculations demonstrate the important role that the adaptive grid computation can play in resolving complicated flow characteristics.
    Additional Material: 13 Ill.
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  • 42
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 615-616 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 43
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 549-559 
    ISSN: 0192-253X
    Keywords: adhesion proteins ; development ; mutations ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Three separate mechanisms of cell-cell adhesion have been shown to appear at different stages of development in Dictyostelium discoideum. During the first few hours of development, the cells synthesize and accumulate a glycoprotein of 24,000 daltons (gp24) that is positioned in the membrane. The time of appearance of gp24 correlates exactly with the time of appearance of cell-cell adhesion in two strains in which temporal control varies by several hours. Antibodies specific to gp24 are able to block cell-cell adhesion during the first few hours of development but not during later development. By 8 hr of development, another glycoprotein, gp80, that is not recognized by antibodies to gp24 accumulates on the surface of cells. This membrane protein mediates an independent adhesion mechanism during the aggregation stage that is resistant to 10 mM EDTA. Antibodies specific to gp80 can block EDTA-resistant adhesion during this stage. During subsequent development, gp80 is removed from the cell surface and replaced by another adhesion mechanism that is insensitive to antibodies to either gp24 or gp80.A λgtll expression vector carrying a Dictyostelium cDNA insert was isolated that directs the synthesis of a fusion protein recognized by antibodies specific to gp24. This cDNA was used to probe a genomic library. A clone carrying a 1.4-kb insert of genomic DNA was recognized by the cDNA and shown to hybridize to a 0.7-kb mRNA that accumulates early in development. This unusually small RNA could code for the small protein, gp24. Southern analysis of restriction fragments generated by various enzymes on Dictyostelium DNA with both the cDNA and genomic clones indicated the presence of two tandem copies of the gene. This may account for the failure to recover mutations resulting in the lack of gp24.Mutations have been recovered that result in the lack of accumulation of gp80, and cells carrying these mutations have been shown to be missing the second adhesion mechanism. These mutant strains are able to complete development because the other adhesion mechanisms are not impaired. Sequential addition of adhesion mechanisms provides a means for the formation of multicellular organisms from previously solitary cells.
    Additional Material: 4 Ill.
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  • 44
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 617-641 
    ISSN: 0271-2091
    Keywords: Higher order ; Boundedness ; Convective transport ; Curvature ; Finite difference ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The paper describes a new approach to approximating the convection term found in typical steady-state transport equations. A polynomial-based discretization scheme is constructed around a technique called ‘curvature compensation’; the resultant curvature-compensated convective transport approximation is essentially third-order accurate in regions of the solution domain where the concept of order is meaningful. In addition, in linear scalar transport problems it preserves the boundedness of solutions. Sharp changes in gradient in the dependent variable are handled particularly well. But above all, the scheme, when used in conjunction with an ADI pentadiagonal solver, is easy to implement with relatively low computational cost, representing an effective algorithm for the simulation of multi-dimensional fluid flows. Two linear test problems, for the case of transport by pure convection, are employed in order to assess the merit of the method.
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  • 45
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 737-737 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 46
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 705-722 
    ISSN: 0271-2091
    Keywords: MHD flow ; Connected channels ; Ducts ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In Sezgin1,2 the problems considered are the magnetohydrodynamic (MHD) flows in an electrodynamically conducting infinite channel and in a rectangular duct respectively, in the presence of an applied magnetic field. In the present paper we extend the solution procedure of these papers to two rectangular channels connected by a barrier which is partially conductor and partially insulator. The problem has been reduced to the solution of a pair of dual series equations and then to the solution of a Fredholm's integral equation of the second kind. The infinite series obtained were transformed to finite integrals containing Bessel Junctions of the second kind to avoid the computations of slowly converging infinite series and infinite integrals with oscillating integrands. The results obtained compared well with those of Butsenieks and Shcherbinin3 which were obtained for the perfectly conducting barrier separating the flows.
    Additional Material: 13 Ill.
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  • 47
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    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 48
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 741-742 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 49
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 743-758 
    ISSN: 0271-2091
    Keywords: MHD Flow ; Half-plane ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We investigate the magnetohydrodynamic flow (MHD) on the upper, half of a non-conducting plane for the case when the flow is driven by the current produced by an electrode placed in the middle of the plane. The applied magnetic field is perpendicular to the plane, the flow is laminar, uniform, steady and incompressible. An analytical solution has been developed for the velocity field and the induced magnetic field by reducing the problem to the solution of a Fredholm's integral equation of the second kind, which has been solved numerically. Infinite integrals occurring in the kernel of the integral equation and in the velocity and magnetic field were approximated for large Hartmann numbers by using Bessel functions. As the Hartmann number M increases, boundary layers are formed near the non-conducting boundaries and a parabolic boundary layer is developed in the interface region. Some graphs are given to show examples of this behaviour.
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  • 50
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 769-802 
    ISSN: 0271-2091
    Keywords: Three-dimensional cavity flow ; Incompressible flow ; Taylor-Görtler vortices ; Secondary flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A role of numerical methods in engineering research is illustrated in the present work, namely the use of computer algorithms as experimental facilities. A complex recirculating flow in a three-dimensional cavity was simulated and an extensive data base was generated which complements data measured in concurrent physical experiments. The objective of this numerical investigation was to improve understanding of physical phenomena in recirculating flows. The dominant physical phenomena in this shear-driven flow simulation are Taylor-Görtler vortices. These structures are intimately coupled with the primary recirculating flow and the effects of end-wall viscous damping.
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  • 51
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 863-864 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 52
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1095-1105 
    ISSN: 0271-2091
    Keywords: Euler Equations ; Riemann Solver ; Generalized Co-ordinates ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A finite difference scheme based on flux difference splitting is presented for the solution of the two-dimensional Euler equations of gas dynamics in a generalized co-ordinate system. The scheme is based on numerical characteristic decomposition and solves locally linearized Riemann problems using upwind differencing. The decomposition is for a generalized co-ordinate system and a convex equation of state. This ensures good shock-capturing properties when incorporated with operator splitting and the advantage of using body-fitted co-ordinates. The resulting scheme is applied to supersonic flow of real air' past a circular cylinder.
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  • 53
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    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 54
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1165-1181 
    ISSN: 0271-2091
    Keywords: Grid ; Net ; Control points ; Curve ; Interpolation ; Tensor ; Transfinite ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Local control points are established within the context of algebraic grid generation. The method of generation is based upon a multidirectional assembly of multisurface transformations that incorporates the best features of tensor product and Boolean sum constructions. Upon assembly, the resultant capability is the capacity to conform precisely to prescribed boundaries while being able to manipulate the grid through a sparse net of control points.
    Additional Material: 10 Ill.
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  • 55
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 933-942 
    ISSN: 0271-2091
    Keywords: Least squares ; Finite elements ; Non-linear ; Hyperbolic ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A class of stable least-square finite element methods for non-linear hyperbolic problems is developed and some exploratory studies made. The methods are based on modifying the L2-norm of the. residual and a related approximation to the H1-norm of the residual. The effect of the additional terms in these residual functionals is to introduce a dissipative effect proportional to the solution gradient. This acts to stabilize the solution for non-linear hyperbolic problems which generate shocks. Numerical results for a one-dimensional nozzle and shock tube problem demonstrate the accuracy and stability of the method. Results are for an implicit scheme and calculations for linear, quadratic and cubic elements are given.
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  • 56
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1119-1120 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 57
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1121-1134 
    ISSN: 0271-2091
    Keywords: Spectral multi-domain method ; Viscous compressible flow ; Shock waves ; Chemical kinetics ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The first application of a spectral multi-domain method for viscous compressible flow is presented. The method imposes a global flux balance condition at the interface so that high-order continuity of the solution is preserved. The global flux balance is imposed in terms of a spectral integral of the discrete equations across adjoining domains. Since the discretized equations interior to each domain are solved uncoupled from each other and since the interface relation has a block structure, the solution scheme can be adapted to the particular requirement in each subdomain. To illustrate these advantages a Mach 11 shock calculation is presented to study the chemical kinetics initiated as air passes through a fully resolved shock wave.
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  • 58
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 995-996 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 59
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1037-1050 
    ISSN: 0271-2091
    Keywords: Space Conservation ; Numerical Calculation ; Fluid Flow ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In the numerical solutions of fluid flow problems in moving co-ordinates, an additional conservation equation, namely the space conservation law, has to be solved simultaneously with the mass, momentum and energy conservation equations. In this paper a method of incorporating the space conservation law into a finite volume procedure is proposed and applied to a number of test cases. The results show that the method is efficient and produces accurate results for all grid velocities and time steps for which temporal accuracy suffices. It is also demonstrated, by analysis and test calculations, that not satisfying the space conservation law in a numerical solution procedure introduces errors in the form of artificial mass sources. These errors can be made negligible only by choosing a sufficiently small time step, which sometimes may be smaller than required by the temporal discretization accuracy.
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  • 60
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1459-1463 
    ISSN: 0271-2091
    Keywords: Finite differences ; Navier-Stokes equations ; Poisson equation ; Pressure equation ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This work comments on a recent paper by J. C. Strikwerda in SIAM Journal on Scientific and Statistical Computing, in an attempt to clear up the evident confusion regarding the use of a Poisson equation for pressure in incompressible Navier-Stokes solutions.
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  • 61
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1513-1522 
    ISSN: 0271-2091
    Keywords: Corrosion pits ; Fluid flow ; Finite element techniques ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Simulation of the dissolution of an active corrosion pit in the presence of fluid flow was carried out with the use of finite element techniques. The model included multiple species in solution, reaction equilibria and transport by diffusion, convection and migration. The mathematical model was used to examine the effect of fluid flow on the pitting of nickel in neutral chloride solution. The pit dissolution rate was found to decrease with increasing flow owing to potential field effects. The capabilities demonstrated in this paper represent a significant advancement in the modelling of pitting corrosion phenomena.
    Additional Material: 5 Ill.
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  • 62
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1491-1511 
    ISSN: 0271-2091
    Keywords: Glass process engineering ; Melting ; 3D finite elements ; FIDAP ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Traditionally glass process problems have been studied using laboratory and two-dimensional computer simulation techniques to quantify the melting, cooling and distribution of the molten glass and its quality. Although these approaches are adequate for a large number of simple glass systems, there are processes with asymmetric geometries and operating conditions which cannot neglect the effect of the third dimension. During the past few years, with the advent of commercial parallel processors and corresponding software, extensive progress has been made with the implementation of full three-dimensional glass flow simulations. Several development applications using FIDAP will be illustrated for electric melters, circular refiners and contoured forehearths. The discussion will cover the problem set-ups, mesh generation, solution strategy, post-processing and results. The advantages and developmental needs of FIDAP will be highlighted from the point of view of applied glass process engineering.
    Additional Material: 18 Ill.
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  • 63
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 1217-1227 
    ISSN: 0271-2091
    Keywords: Multigrid ; 3D Navier-Stokes solver ; Flow in turbomachinery ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper describes the implementation of a 3D Navier-Stokes solver within the framework of a multigrid strategy. The ability of multigrid to improve and sustain code performance over a range of mesh sizes and a variety of difficult flow problems is investigated. The code is applied to the study of the shock-induced boundary layer separation on a channel hump, the flow in a 2D cascade of compressor blades, the secondary flow development in a linear cascade of gas turbine blades and the Eckardt backswept centrifugal impeller. In each case multigrid leads to significantly improved performance.
    Additional Material: 4 Ill.
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  • 64
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 55-64 
    ISSN: 0271-2091
    Keywords: Boundary element method ; Chemical reaction ; Convective diffusion ; Numerical quadrature ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A boundary element method is presented for a steady state convective diffusion problem with a first-order chemical reaction. In the chemical reaction system the usual conservation law for calculation of the diagonal components of the matrix H cannot be satisfied. Thus in the boundary element formulation the emphasis is laid on how to compute these diagonal components. The main aim of this paper is to present the method of numerical quadrature to obtain the principal values, using the splitting technique to treat the singular integration.
    Additional Material: 5 Ill.
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  • 65
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 31-53 
    ISSN: 0271-2091
    Keywords: Non-isentropic transonic flows ; Non-uniqueness ; Stream function solutions ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Different models for inviscid transonic flows are examined. The common assumptions that the flow is isentropic and irrotational are critically evaluated. Entropy and vorticity correction procedures for potential and stream function formulations are presented, together with the details of the treatment of shocks and wakes, and drag and lift calculations. The non-uniqueness problem of the potential formulation is studied using different artificial viscosity forms. Numerical results are compared with Euler solutions.
    Additional Material: 11 Ill.
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  • 66
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 65-79 
    ISSN: 0271-2091
    Keywords: Boundary-type finite element method ; Mild-slope equation ; Wave diffraction-refraction ; Harbour oscillation ; Co non-conforming element ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A new combinative method of boundary-type finite elements and boundary solutions is presented to study wave diffraction-refraction and harbour oscillation problems. The numerical model is based on the mild-slope equation. The key feature of this method is that the discretized matrix equation can be formulated only by the calculation of a line integral, since the interpolation equation which satisfies the governing equation in each element is used. The numerical solutions are compared with existing analytical, experimental, observed and other numerical results. The present method is shown to be an effective and accurate method for water surface wave problems.
    Additional Material: 16 Ill.
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  • 67
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 81-90 
    ISSN: 0271-2091
    Keywords: Hydrodynamic stability ; Acoustic waves ; Cryogenic oscillations ; Taconis vibration ; Sondhauss tube ; Continuation ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical method to obtain the neutral curve for the onset of acoustic oscillations in a helium-filled tube is described. Such oscillations can cause a serious heat loss in the plumbing associated with liquid helium dewars. The problem is modelled by a second-order, ordinary differential eigenvalue problem for the pressure perturbation. The numerical method to find the eigenvalues and track the resulting points along the neutral curve is tailored to this problem. The results show that a tube with a uniform temperature gradient along it is much more stable than one where the temperature suddenly jumps from the cold to the hot value in the middle of the tube.
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  • 68
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 121-122 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 69
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 91-96 
    ISSN: 0271-2091
    Keywords: Boundary elements ; Free surface ; Riabouchinsky cavity flow ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper describes a method for the numerical solution of a Riabouchinsky cavity flow. Application of a boundary element method leads to a system of non-linear equations. The mild singularity appearing at the separation point is treated with the introduction of a curved boundary element, which satisfies the exact behaviour of the free boundary in that neighbourhood.
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  • 70
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    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 71
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 243-244 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 72
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 305-315 
    ISSN: 0271-2091
    Keywords: Turbulent flow ; Non-circular passage ; Finite volume ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical finite volume prediction method for arbitrary-shaped passages has been applied to the case of fully developed axial turbulent flow past a rod eccentrically placed in a circular tube. The numerical method was based on an orthogonal curvilinear mesh and employed an algebraic stress transport model to calculate the full three-dimensional velocity field directly from the governing partial differential equations. This study is one of a series of applications of this prediction method to a range of different non-circular passages that have been made in order to establish the capabilities and usefulness of this type of procedure. The present eccentric rod case was the subject of a comprehensive experimental investigation by Kacker1 which has enabled a detailed comparison to be made between the present predictions and the measurements. This comparison included local distributions of axial velocity, wall shear stress and secondary velocities; and although found to be satisfactory overall, some differences in detail revealed possible shortcomings in the measurement of secondary flow. This, together with other previously reported cases, indicates, that, although the present method cannot be expected to replace experiment in providing turbulent passage flow data, it has an important role to play in interpreting and supplementing experiments.
    Additional Material: 10 Ill.
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  • 73
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 327-338 
    ISSN: 0271-2091
    Keywords: Boundary element method ; Stokes flow ; Re-entrant boundaries ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Numerical solutions are presented for two-dimensional low Reynolds number flow in a rotating tank with stationary barriers. The boundary element method is employed, assuming straight panels and quadratic source distribution. The feasibility of repositioning the nodes as a way to minimize the error is explored. A stretching parameter places smaller elements near the re-entrant regions. Elementary error analysis shows uniform improvement in the solution with stretching. The changing eddy pattern for different numbers and sizes of the barriers is compared with experimental results.
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  • 74
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 339-349 
    ISSN: 0271-2091
    Keywords: Computational methods ; Pipelines ; Pressure transients ; Two-dimensional model ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The paper presents a two-dimensional model for the investigation of pressure transients in pipelines. The governing equations have been established and a method of solving the equations using the centre implicit method is presented. The theoretically predicted values are compared with the experimentally determined pressure transients for horizontal pipelines with a valve at the end. The two-dimensional model gives results which are accurate than those of the one-dimensional model and are in good agreement with the experimental results.
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  • 75
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 365-366 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 76
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 367-368 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 77
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    International Journal for Numerical Methods in Fluids 8 (1988) 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 78
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 405-416 
    ISSN: 0271-2091
    Keywords: Navier-Stokes equations ; Vorticity-velocity ; Finite difference ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical method for computing high-Re laminar steady flows is presented. The incompressible Navier-Stokes equations are expressed in terms of vorticity-velocity variables, discretized in space by finite differences on a staggered grid and advanced in time by a scalar alternating direction implicit (ADI) procedure, which allows a fully vectorized computer code. The accuracy and efficiency of the present formulation are discussed in comparison with the standard ω-ψ and u, v, P forms. Numerical results are presented for two test cases: the driven cavity at Re up to 5000 and the backward-facing step at Re up to 800.
    Additional Material: 8 Ill.
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  • 79
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 369-385 
    ISSN: 0271-2091
    Keywords: 3D flow ; Vector potential vorticity vector ; Finite difference method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical method for the solution of the vector potential/vorticity vector formulation of the transient, fully three-dimensional Navier-Stokes energy and continuity equations has been applied to simulate the development of natural convective flow within a ‘box’ after a sudden temperature change on a vertical portion of the wall. Only one cavity size has been considered, this having a vertical height of three times its width and a horizontal length of six times its width. A single heated rectangular hot spot or ‘element’ on an otherwise adiabatic wall is centred between the vertical end walls. The opposite vertical wall is held at the intial fluid temperature, and all other walls are assumed to be adiabatic. Fluid properties have been assumed constant except for the density change with temperature that gives rise to the buoyancy force. The numerical method is an underrelaxation Gauss-Seidel method using finite differencing at each time step. Solutions have been obtained for a Prandtl number of 0.71, for Rayleigh numbers, based on the width, of between 0 and 100000 and for a number of heated element locations and sizes.
    Additional Material: 13 Ill.
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  • 80
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 417-440 
    ISSN: 0271-2091
    Keywords: Multigrid method ; Pressure correction ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The use of multigrid methods in complex fluid flow problems is recent and still under development. In this paper we present a multigrid method for the incompressible Navier-Stokes equations. The distinctive features of the method are the use of a pressure-correction method as a smoother and a novel continuity-preserving manner of grid coarsening. The shear-driven cavity problem is used as a test case to demonstrate the efficiency of the method.
    Additional Material: 15 Ill.
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  • 81
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 387-404 
    ISSN: 0271-2091
    Keywords: Boundary-fitted co-ordinates ; SIMPLE algorithm ; Non-staggered grid ; Cascade flow ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The incompressible flow through a two-dimensional cascade is computed using the SIMPLE algorithm in a boundary-fitted co-ordinate system. With the standard staggered grid arrangement the numerical solution was found to allow localized pressure oscillations to persist adjacent to the periodic boundaries. These oscillations were found to be a consequence of the extended momentum control volumes which are required in this region of the cascade. Such control volumes may be removed by the use of appropriately non-staggered velocity storage locations, which are also desirable in the boundary-fitted system since the Cartesian velocity components are no longer related to the grid line orientations. However, this storage permits the propagation of global pressure oscillations, which were previously suppressed by the staggered grid arrangement. This paper attempts to define a solution procedure which uses non-staggered velocity locations and is able to eliminate the consequent global pressure oscillations. To achieve this aim, two forms of pressure correction scheme were considered. The first implemented the scheme proposed by Vanka et al. but was found to be inadequate in the open part of the cascade, whereas the second employed a modification of the scheme proposed by Rhie and Chow and was found to be successful in all regions of the flow. The results computed using this scheme were compared with the available experiment results.
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  • 82
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 441-461 
    ISSN: 0271-2091
    Keywords: Multigrid ; Local mode analysis ; Pressure correction ; Ellipticity ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A local mode Fourier analysis is used to assess the suitability of the SIMPLE pressure-correction algorithm to act as a smoother in a multigrid method. The necessary ellipticity of the Navier-Stokes equations and their discrete representation are established. The theoretical analysis is compared with practical results.
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  • 83
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 491-492 
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 84
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    International Journal for Numerical Methods in Fluids 8 (1988), S. 463-474 
    ISSN: 0271-2091
    Keywords: Viscous ; Turbulent ; Subsonic ; Duct ; Diffuser Navier-Stokes ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Three-dimensional, compressible, internal flow solutions obtained using a thin-layer Navier-Stokes code are presented. The code, formulated by P.D. Thomas, is based on the Beam-Warming implicit factorization scheme; the boundary conditions also are formulated implicitly. Turbulent flow is treated through the use of the Baldwin-Lomax two-layer, algebraic eddy viscosity model. Steady-state solutions are obtained by solving numerically the time-dependent equations from given initial conditions until the time-dependent terms become negligible. The configuration considered is a rectangular cross-section, S-shaped centreline diffuser duct with an exit/inlet area ratio of 2.25. The Mach number at the duct entrance is 0.9, with a Reynolds number of 5.82 × 105. Convergence to the final results required about 2700 time steps or 11 hours of CPU time on our CRAY-1M computer. The averaged residuals were reduced by about two orders of magnitude during the computations. Several regions of separated flow exist within the diffuser. The separated flow region on the upper wall, downstream of the second bend, is by far the largest and extends to the exit plane.
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  • 85
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    Developmental Genetics 9 (1988) 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
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  • 86
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    Developmental Genetics 9 (1988), S. 1-12 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 5 Ill.
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  • 87
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    Developmental Genetics 9 (1988), S. 13-22 
    ISSN: 0192-253X
    Keywords: ontogeny ; lethality ; gene expression ; mRNA ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Cadmium is a toxic metal that induces the expression of metallothionein genes in many tissues and that binds avidly to metallothionein, a soluble transition metal binding protein. The present study examined the temporal pattern and magnitude of accumulation of metallothionein mRNA in liver of C57BL/6J mice of various ages treated with cadmium. In adult female mice, accumulation was dependent on the dosage level of cadmium and related to the concentration of this metal in liver. The accumulation of metallothionein mRNA in liver depended on age at exposure to cadmium. Intraperitoneal administration of 2 mg of cadmium per kg provoked small increases (two- to threefold) in levels of metallothionein mRNA in livers of 7- and 14-day-old mice. In contrast, cadmium treatment of 28- and 56-day-old mice resulted in 12- to 19-fold increases in levels of metallothionein mRNA in liver with maximum increases occurring 3 to 4 hr after treatment. Because similar patterns for the accumulation of cadmium of liver were found in 7-, 28-, and 56-day-old mice, observed age-dependent differences in induction of metallothionein mRNA in liver were probably not due to differences in the accumulation of cadmium in this organ. Taken together, these data suggest that tissue-specific factors controlling the expression of metallothionein genes may account for developmental variation in the inducibility of these genes by cadmium. Ontogenic variation in accumulation of metallothionein mRNA after cadmium treatment may be a factor in developmental variation in the acute lethality of cadmium in C57BL/6J mice.
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  • 88
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    Developmental Genetics 9 (1988), S. 23-35 
    ISSN: 0192-253X
    Keywords: maternal-specific transcripts ; genomic clones ; developmental RNA expression ; in situ chromosomal localization ; embryogenesis ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The unique cellular and genetic events which occur during the first few hours of Drosophila embryogenesis suggest that there are genes whose function is entirely or largely limited to this stage; this is supported by both genetic and molecular evidence. To identify some of these genes and characterize the relative contribution of specifically maternal and specifically zygotic transcription to early embryogenesis, we used competition and differential screening of a Drosophila genomic DNA library to obtain blastoderm- and maternal-differential sequences [Roark et al.: Dev Biol 109:476-488, 1985]. We describe here the Eco RI restriction fragments, chromosomal location, and size and developmental pattern of expression of the RNAs transcribed from 19 maternal-differential sequences. Five sequences encode maternal-specific transcripts (50-150-fold more abundant in maternal RNA than at any other stage). The maternal-specific and maternal-differential sequences are located at single sites on all major chromosome arms. Comparison of these sites with the sites of presently mapped maternal-effect genes shows several possible correlations, including one region containing three maternal-effect lethal mutations and two maternalspecific sequences.
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  • 89
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    Developmental Genetics 9 (1988), S. 37-48 
    ISSN: 0192-253X
    Keywords: eggshell ; female sterile mutant ; endochorion ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Four female-sterile mutants, fs(l)K451, fs(1)K1214, fs(1)K575TS, and fs(1)384, were studied in terms of chorion structure and chorion protein composition. The first three of these mutants cause morphological defects, ie, substantial underproduction and disruption of the endochorion, correlated with underproduction of the six major chorion proteins, s15-s38; the phenotypes are consistent with the observation that these mutants interfere with amplification of the major chorion genes that encode the s15-s38 proteins [Orr et al.: Proc Natl Acad Sci USA 81:3773-3777, 1984; Komitopoulou et al.: Dev Genet 7:75-80, 1986]. The fourth mutant, fs(1)384, and its alleles do not interfere with production of the major chorion proteins and the morphologically detectable bulk of the endochorion but lead to failure of endochorionic organization. Apparently this complementation group is responsible for a minor chorion product, which is evidently important morphogenetically and which is processed posttranslationally in a complex manner [Bauer and Waring: Dev Biol 121:349-358, 1987].
    Additional Material: 5 Ill.
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  • 90
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 71-71 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 91
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 69-69 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 92
    ISSN: 0192-253X
    Keywords: Daucus carota ; auxin ; gene expression ; mutant ; filtration-enrichment procedure ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Cell cultures of the carrot Daucus carota are a useful experimental system for studying the genetic regulation of plant embryogenesis. A modified filtration-enrichment procedure was used to isolate 21 temperature-sensitive variants in somatic embryogenesis; the variants display normal embryo development at the permissive temperature (24°C) and altered development at the restrictive temperature (33°C). Temperature-shift experiments were performed on these variants to determine the timing of gene action for the putative temperature-sensitive alleles. According to their phenotypes at the restrictive temperature, these variants can be divided into six classes: No Growth, Callus Proliferation, Globularstage Block, Oblong-stage Block, Lateral Growth, and Root Formation. Although many variants exhibit lengthy temperature-sensitive periods, the temperature sensitivity of some variants is restricted to one or two embryonic stages. These results plus those in the literature are incorporated into a preliminary model concerning the genetic regulation of carrot embryogenesis.
    Additional Material: 9 Ill.
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  • 93
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988) 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 94
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 73-89 
    ISSN: 0192-253X
    Keywords: mutants ; embryogenesis ; floral organogenesis ; trichomes ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Additional Material: 6 Ill.
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  • 95
    Electronic Resource
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988) 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 96
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 91-120 
    ISSN: 0192-253X
    Keywords: actin filament bundles ; ethyl methane sulfonate ; female sterile mutants ; in terallelic complementation ; oocyte determination ; ovarian tumor genes ; phenocritical thresholds ; polyfusomes ; polytene nurse cell chromosomes ; polytrophic meroistic ovaries ; pseudonurse cells ; Q-T-P-O values ; rhodaminyl phalloidin ; temperature-sensitive mutants ; transformed oocytes ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The ovarian tumor gene behaves as if it encodes a product (OGP), which is required durirng several early steps in the transformation of oogonia into functional oocytes. Seventeen ethyl methane sulfonate-induced mutations have been studied, and their mutant phenotypes can be explained as graded responses by individual germ cells to different levels of OGP synthesized by the mutant germ cells themselves. The lowest and highest levels of OGP appear to be produced by otu10 and otu14, respectively. The 15 mutants with intermediate OGP levels are temperature sensitive; subnormal temperatures improve ovarian development, while above-normal temperatures suppress it. A subgroup ofthese mutants are unable to form a system of actin microfilament bundles in the cortical cytoplasm of their nurse cells during stage 10B, and these defective nurse cells are unable to transport their cytoplasm to the oocyte, as normally happens between stages 10B and 12. In addition to its role in the actin-mediated transport of nurse cell cytoplasm, OGP also appears to alter the morphology of giant polytene chromosomes, which form as the nurse cells undergo endocycles of DNA replication. Genetic evidence suggests that otu also encodes a second product (SP) that is utilized late in oogenesis. SP is required for the synthesis in the ooplasm of glycogen-rich, beta yolk spheres. Products of the otu gene also play a vital but unknown role in embryogenesis.
    Additional Material: 10 Ill.
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  • 97
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 167-180 
    ISSN: 0192-253X
    Keywords: enzyme pattern ; gene expression ; protein synthesis ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Aldehyde oxidase (AO) and pyridoxal oxidase (PO) distribution patterns were determined in the imaginal wing discs for a series of strains of Drosophila melanogaster heterozygous for different Minute mutations. The mutant severity ranged from very weak to strong. The results show an inverse response of AO and PO to the expressivity of the Minute mutation: in weaker Minutes the extent of the AO positive area increases, whereas PO activity disappears. The results are discussed with reference to an impaired protein synthesis in Minutes.
    Additional Material: 6 Ill.
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  • 98
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 121-154 
    ISSN: 0192-253X
    Keywords: mouse chimeras ; coat-color ; or patterns ; Video-image analysis ; microcomputer ; C3H/HeJ ; BALB/c ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The possible application of microcomputer-based video-image analysis systems for the quantitative description of coat-color patterns in artificially produced chimeras and genetic mosaics of mice was investigated using a program developed by theauthor. This system is capable of extracting, from sampled images of pelts, the morphometric image features as defined by Pratt [1978] that are essential to the quantitative description of coat-color patterns in these animals. It does so with reasonable accuracy and speed and at low cost. No description of any similar system has been published in the literature. Performance of our system is described using C3H/HeJ ↔BALB/c chimeras as examples.The complex phenotypic expression of hair pigmentation in mice makes the use of a video-image analysis system like this one essential to evaluate the morphometric parameters of the patterns (e.g., the mixing ratios between the two components, the number of different-colored stripes, etc.) more precisely and reproducibly than has been done yet in the literature.The results indicate that the number of melanoblast clones in mice, as estimated from the number of minimal recognizable stripes (MRS), might be considerably largerthan previously indicated; the figure presently obtained, i.e., 22.3 ± 2.16 unilaterally in terms of the hypothetical maximum number of stripes (HMNS) (28.73 ± 1.55, after correction for the random clumping) in the thoracicolumbar region of the mouse closely approximates the number of the somites in that region. Concerning the degree of mixing between the two components, it was proposed that the unmixed portion of the components derived from one strain increases in proportion to the second power of the increase in the relative total content of the same components. Work is in progress in our laboratory to analyze a large number of the chimeric pelts using the system described in this paper.
    Additional Material: 15 Ill.
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  • 99
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 155-165 
    ISSN: 0192-253X
    Keywords: embryonic lethal ; agouti locus ; trophectoderm ; inner cell mass ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The tissue specificity of the lethal yellow mutant was investigated by separation of blastocyst tissues. Embryos from experimental (Ay/ae × Ay/ae) and control (ae/ae × Ay/ae) crosses of the AG/CamPa inbred strain were recovered at 3.5 days post coitum, cultured for 24 hours, and then mechanically dissected into the component tissues of the blastocyst, the inner cell mass (ICM), and trophectoderm. These fragments were then cultured separately, with or without a feeder layer of inactivated fibroblasts, for an additional 3-5 days. Comparisons between experimental and control crosses indicated that the lethal Ay/Ay embryos were among the blastocysts successfully dissected but that both the ICM and trophectoderm from lethal embryos failed to develop further in vitro, eithal with or without feeders.With retrospective identification of the lethal embryos, it was found that at 4.5 days, after 1 day of culture, they had formed morphologically normal blastocysts but were frequently more fragile upon dissection and had smaller ICMs. Although none had hatched from the zona pellucida, some had ruptured it and were halfway out. With culture, lethal ICMs showed no development, and lethal trophectoderm usually attached but showed very limited outgrowth. Thus, no rescue of lethal tissue was shown with dissection and in vitro culture, and results are consistent with the gene affecting both tissues of the late blastocyst.
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  • 100
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    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 9 (1988), S. 213-213 
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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