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  • 11
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 47 patients with various pituitary tumours plasma cortisol, LH, FSH, prolactin, and GH were measured by radioimmunoassays to investigate anterior pituitary function. In 14 subjects LH-RH and TRH stimulation tests were performed to assess pituitary reserve before, during, and after surgical therapy. The mean cortisol levels were raised during and after the operative procedures until the 14th postoperative days. In patients with functionless tumours the other hormone concentrations remained nearly unchanged and in the normal ranges. After the removal of the tumour a rapid decrease in hormone levels, as might be expected, was rare, with the exception of the GH and prolactin levels in patients with hypersecretion. The postoperative stimulation tests showed a maintained secretory pituitary reserve due to active tissue left behind after operative removal of the tumour.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 54 (1980), S. 181-189 
    ISSN: 0942-0940
    Keywords: Percutaneous needle trephination ; twist drill trephination ; CSF ; hydrocephalus ; ICP monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 56 neurosurgical patients 70 percutaneous needle trephinations were performed. This method was mostly used in patients with acute increase of ICP due to occlusive hydrocephalus of various aetiologies. Thanks to the accuracy and exhaustiveness of CT information, and thanks to the simplicity and safety of percutaneous needle trephination, this latter could be more and more used in daily clinical practice as a diagnostic and therapeutic procedure, for example for the study of adult hydrocephalus, for provisional external ventricular drainage, for treatment of CSF infections, and for ventricular bleedings (also in newborns and premature infants). No serious complication was seen even after prolonged CSF drainage over a period of 41 days. The method of PNT, as described in detail, can be used under sterile conditions at the bedside, on the stretcher in the emergency room, or in the CT or X-ray laboratory. It fulfils the criteria for clinical acceptance: simplicity, low risk, reliability, exactness, and effectiveness.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 14
    ISSN: 1432-0932
    Keywords: Intervertebral disc ; Nd-YAG laser ; Lumbosacral region
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective study on 50 patients, the 1064-nm Nd-YAG laser was used to denaturate protruding lumbar discs. The method of Ascher [1] was modified using a saline pressure infusion system. Early results show a very good decompressive effect with 48 out of 50 patients in the categories very good and good. At follow-up (mean 184 days postoperation) 31 out of 46 were in these categories, indicating a longer lasting retrieval of the protruded mass. A marked reduction of clinical nerve compression signs was noted. No severe complications occurred. Due to the irrigation system less low back pain was reported. The method seems promising in the standard neurosurgical setting
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 54 (1999), S. 843-845 
    ISSN: 1432-1041
    Keywords: Key words Piritramide ; Protein binding ; Acute phase response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Piritramide is a lipophilic opioid, which is widely used for postoperative analgesia and analgosedation in Europe. In this study we investigated the influence of various protein concentrations (total protein, 1-acid glycoprotein, albumin) and the postoperative acute phase response on the protein binding of piritramide. Methods: The influence of various protein concentrations on the protein binding of piritramide was investigated by either diluting the serum samples of five volunteers with isotonic saline or by adding different amounts of 1-acid glycoprotein. Albumin binding was measured in a 5% human albumin solution. The impact of the postoperative acute phase response was investigated by obtaining daily serum samples from 18 surgical patients until the third postoperative day, and measuring piritramide protein binding, 1-acid glycoprotein, total protein and albumin. Results: There was a significant relationship between piritramide protein binding and the concentrations of total protein and 1-acid glycoprotein. The binding to albumin was 88%. During the postoperative acute phase response, the protein binding of piritramide did not change. Serum concentrations of 1-acid glycoprotein increased, whereas total protein and albumin decreased. Conclusion: Although there were significant changes in the piritramide-binding proteins, 1-acid glycoprotein and albumin, during the postoperative acute phase response, the protein binding of piritramide did not change. Therefore, a change in protein binding, which might be one factor to be considered in determining piritramide dosage in the postoperative period, does not have to be taken into account.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Child's nervous system 3 (1987), S. 232-234 
    ISSN: 1433-0350
    Keywords: Arachnoid cysts ; Subdural hematoma ; Hydrocephalus ; Peritoneal shunt ; Microsurgical technique ; Congenital lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 11 cases of intracranial, temporal arachnoid cysts the etiology, clinical and radiographic findings, surgical treatment, and outcome are reviewed in respect of post-traumatic subdural hematoma. Cysts of the middle cranial fossa are susceptible to trauma, which may cause bleeding either into the cyst or into the subdural space. Signs and symptoms of increasing intracranial pressure (ICP), local neurological deficits, and sometimes epileptic seizures may lead to hospitalization. CT or MRI scans are diagnostic in these cases. In cases of intracranial mass lesion with displacement of the midline structures and increasing ICP, osteoplastic craniotomy is performed and the lateral wall of the cyst is resected down to the tentorial notch by a microsurgical procedure, with opening into the basal cisterns. There were no operative or postoperative complications in 11 consecutive cases. However, one boy required a cystoperitoneal shunt 3 months later as a result of hydrocephalus following subdural hematoma. Asymptomatic arachnoid cysts are discussed with respect to brain function and social behavior.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1435-2451
    Keywords: Key words Head and neck neoplasms ; Enteral resection ; Jejunal autotransplantation ; Reconstruction of the oropharyngeal cavity ; Schlüsselwörter Mundhöhlenkarzinom ; Dünndarmresektion ; Jejunum Autotransplantation ; Rekonstruktion der Mundhöhle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Rekonstruktion im Mundhöhlen-, Pharynx- und im kranialen Ösophagusbereich nach ausgedehnten, radikalen Tumorresektionen stellt eine interdisziplinäre Herausforderung dar. Eine vielfach favorisierte Technik ist die rekonstruktive Jejunumautotransplantation, bei welcher der Abdominalchirurg mit der Gewinnung des Autotransplantats beauftragt ist. Die Notwendigkeit des zusätzlichen Abdominaleingriffs macht die vorgestellte Analyse der perioperativen Komplikationen bei der Jejunumentnahme notwendig. Zusätzlich wurden 35 von 66 noch lebenden Patienten mit einem Nachuntersuchungsintervall von durchschnittlich 21 (2–63) Monaten bezüglich abdominaler Spätkomplikationen evaluiert. Bei 90 wegen eines Malignoms der Mundhöhle oder des Oropharynx operierten Patienten war die perioperative Letalität 7,8% (7/90), in keinem Fall auf Basis einer entnahmeassoziierten abdominalen Komplikation. Eine abdominale Revision erfolgte wegen subkutaner Bauchdeckendehiszenz. Aus nicht mit der Dünndarmentnahme in direktem Zusammenhang stehender Ursache mußten 4 Patienten relaparotomiert werden (2 noch während des Krankenhausaufenthalts, 2 Patienten nach erfolgter Entlassung). Bei 5 Patienten wurden konservativ behandelbare minimale Komplikationen festgestellt. Die Nachuntersuchung zeigte außer in 6 Fällen mit kleinen Narbenhernien keine Spätkomplikationen auf. Insgesamt ist festzuhalten, daß trotz des zumeist erhöhten perioperativen Risikos dieses Patientenguts die Komplikationsrate des zusätzlichen Abdominaleingriffs zur Gewinnung des optimalen Rekonstruktionsgewebes gering und vertretbar erscheint.
    Notes: Abstract Reconstruction after radical tumor resection in the oropharyngeal region still represents an interdisciplinary challenge. Autotransplantation of the jejunum is a popular procedure, in which the abdominal surgeon's main task is that of harvesting enteral tissue. To evaluate this technique, a careful analysis of accompanying perioperative abdominal complications was performed. Additionally, we reexamined 35 of 66 patients still living after a follow-up period of 21 (range 2–63) months on average. The perioperative mortality of 90 patients treated for oropharyngeal malignancy using the described procedure was 7.8%. None of the perioperative deaths was caused by an abdominal complication associated with enteral resection. One abdominal reoperation was performed because of abdominal wall dehiscence. For reasons not related to enteral resection, four further patients had to be relaparotomized, two of them during their hospital stay and two after leaving hospital. In five cases we observed minor complications which could be treated nonsurgically. In the follow-up reexamination we detected no abdominal late-onset complication except small incisional hernias in six cases. Finally, we concluded that despite an elevated overall operative risk in this population, complications owing to jejunal resection were comparably low. The data regarding the rate of complications classify jejunal resection as a safe procedure for reconstructive purposes in patients suffering from oropharyngeal malignancy.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1435-0130
    Keywords: Key words Jejunal autotransplantation ; Head and neck carcinoma ; Complications ; Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The study was performed to evaluate abdominal complications related to jejunal segment resection for reconstruction after radical oropharyngeal tumor resection. Perioperative complications of 104 patients (median age, 53.7 years; 23 female; 81 male) who underwent surgery for oropharyngeal malignancy after radiochemotherapy and the long-term morbidity of 35 patients after a median follow-up period of 21 months are analyzed. The perioperative mortality was 8.7% (9/104); none of the perioperative deaths was caused by an abdominal complication associated with the jejunal resection. In three cases, repeat laparotomy was performed within 30 days of jejunal autotransplantation: in two of them the reason was not directly associated with bowel resection and one patient had an abdominal wall dehiscence. In six cases there were minor abdominal complications which could be treated nonsurgically. There was no anastomotic leakage, bowel obstruction or postoperative bleeding. In the follow-up re-examination, no late onset abdominal complications were noted except small incisional hernias in six of the 35 patients; only one required a hernia repair. Despite a potentially increased operative risk in these patients, the complication rate after bowel resection for jejunal autotransplantation was low. This is a safe procedure in patients with oropharyngeal carcinoma.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 81 (1969), S. 932-933 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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