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  • 2015-2019
  • 1985-1989
  • 1975-1979
  • 1970-1974  (1,401)
  • 1965-1969  (693)
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  • 1
    Electronic Resource
    Electronic Resource
    Über Myelom-Zellen im Liquor cerebro-spinalis (1972)
    Springer
    Journal of neurology 202 (1972), S. 229-240 
    Details
    ISSN: 1432-1459
    Keywords: Cerebrospinal Fluid ; Plasmacytoma (IgA) ; Cytodiagnosis ; Immunofluorescence ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem 37jährigen Patienten mit IgA-Plasmocytom zeigte sich während der zweiten Phase der Krankheit, die mit schweren cerebralen Symptomen und Hirnnervenausfällen verlief, eine ausgeprägte Pleocytose im Lumballiquor. Etwa 50–60% der Liquorzellen waren cytologisch und elektronenoptisch teils als reife, ganz überwiegend jedoch als entdifferenzierte Plasmocyten, das heißt als Myelom-Zellen, zu deuten. Übereinstimmend zum immunelektrophoretischen und quantitativen Befund von vermehrtem IgA-Paraprotein und Bence-Jones-Protein im Liquor ließ sich in den meisten Blastomzellen eine entsprechende spezifische Immunfluorescenz nachweisen. Das Auftreten von Myelom-Zellen im Liquor ist unseres Wissens noch nicht beschrieben worden und erklärt sich hier aus der (autoptisch bestätigten) leptomeningealen Lokalisation des Plasmocytoms. In solchen Fällen kann der liquorcytologische Befund die Diagnose entscheiden.
    Notes: Summary A 37-year-old male patient with monoclonal IgA dysproteinemia, severe brain symptoms and cranial nerve disturbances failed to show typical plasmacytoma findings in skull, bones, blood, bone marrow, spleen and lymphatic system. During a second recurrence of his illness a marked pleocytosis of the CSF was observed. 50 to 60% of the cells were classified cytologically and by electron microscopy as blastomatous plasmocytes, i.e. myeloma cells. Specific intracytoplasmatic immunofluorescence corresponded to the presence of IgA and Bence Jones paraprotein which was demonstrated in CSF by immunoelectrophoresis and immunodiffusion. Myeloma cells of CSF have never been described before. Autopsy of this case revealed an unusual type of plasmacytoma which involved the cerebrospinal leptomeninges and subarachnoid spaces mainly. The diagnosis in patients with this disease may be established for sure by the specific cytologic evaluation of the CSF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316224
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  • 2
    Electronic Resource
    Electronic Resource
    Zur Ultrastruktur der Schweineleber bei 24stündiger einfacher hypothermer Konservierung (1972)
    Springer
    Research in experimental medicine 158 (1972), S. 129-151 
    Details
    ISSN: 1433-8580
    Keywords: Preservation ; Porcine Liver ; Hypothermia ; Electron Microscopy ; Lysosomes ; Konservierung ; Schweineleber ; Hypothermie ; Elektronenmikroskopie ; Lysosomen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 6 Schweinelebern wurden durch einfache Unterkühlung 24 Std konserviert und die Strukturerhaltung in verschiedenen Zeitintervallen elektronenmikroskopisch und enzymcytochemisch untersucht. Für die initiale hypotherme Kurzzeitperfusion diente eine mit Kalium und Glucose angereicherte modifizierte Ringer-Lösung, der bei 3 Lebern zusätzlich sog. Zellstabilisatoren (Chlorpromazin und Prednisolon) hinzugefügt worden waren. Schwerwiegende Schädigungen der Ultrastruktur in den Hepatocyten, wie Desorganisation, Fragmentation, Vesikulation und Degranulation des endoplasmatischen Reticulums, Mitochondrienschwellung vom Matrix-Typ, Verklumpung und Margination des Chromatins sowie Rupturen der Zellmembran mit Austritt von Cytoplasmabestandteilen und Kernen in die Disséschen Räume und Sinusoidlichtungen traten vereinzelt nach 6–9stündiger, in der Mehrzahl der Zellen jedoch erst nach 12stündiger Konservierung auf. Die Lysosomen blieben über 18 Std unverändert. Bemerkenswert waren früh einsetzende regressive Veränderungen in den Kupfferschen Sternzellen, die schon nach 6 Std vielfach zu Cytolysen führten. Der Zusatz von Chlorpromazin und Prednisolon zur Perfusionslösung blieb ohne morphologisch erfaßbaren Effekt auf die Erhaltung der Ultrastruktur.
    Notes: Summary 6 porcine livers were preserved by simple hypothermia for 24 hrs. Ultrastructural alterations were studied at various intervals with electron microscopic and enzyme cytochemical methods. A modified Ringer's solution with increased concentrations of potassium and glucose was used for initial hypothermic shorttime perfusion. In 3 of 6 cases cell stabilizers (chlorpromazine and prednisolone) were added to the perfusate. Severe ultrastructural changes such as disorganization, fragmentation, vesiculation, and degranulation of endoplasmic reticulum, swelling of the matrix in mitochondria, aggregation, and margination of chromatin as well as rupture of the plasma membrane followed by the release of cellular constituents into the Dissé spaces and the sinusoids appeared in several liver cells after 6–9 hrs of preservation. In a significant number of cells, however, they were observed only after 12 hrs of preservation. In lysosomes there were no changes for more than 18 hrs of preservation. Especially interesting were early regressive alterations of Kupffer cells leading frequently to cytolysis already after 6 hrs of preservation. The addition of chlorpromazine and prednisolone to the perfusate had no effect on the preservation of ultrastructure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852174
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  • 3
    Electronic Resource
    Electronic Resource
    Electron microscopic study on schizophrenia (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 67-77 
    Details
    ISSN: 1432-0533
    Keywords: Schizophrenia ; Disturbance of Metabolism in the Neuron ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biopsies of a frontal gyrus from both schizophrenic and non-schizophrenic brains were examined by electron microscopy. The results in the schizophrenic brains are as follows: 1. Within the cytoplasm of the nerve cell, the Golgi apparatus was remarkably prominent. 2. Membranous structures, consisting of numerous interconnected tubules were observed in the nerve fibres. Abnormal structures appeared in the synapses and in many synapses vesicles were not observed. 3. Granular and vesicular material accumulated in large amount in the axon-oligodendroglial interface of myelinated nerve fibres: the material was gradually transferred from the axon-oligodendroglial interface to the inner mesoaxon and the outer layers of the myelin sheaths destroying some of the myelin sheaths. Mainly myelinated nerve fibres of medium size were involved. 4. A large amount of lipofuscin-like material was observed in the cytoplasm and the processes of the oligodendroglia. 5. Only the neuron and the oligodendroglia showed specific changes. Among the findings mentioned above, (3) was thought to be specific and originated from the disturbance of the metabolism of the neuron, due probably to some enzyme disturbance in the neuron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687903
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  • 4
    Electronic Resource
    Electronic Resource
    Involvement of the perineurium in experimental allergic neuritis: Electron microscopic observations (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 139-149 
    Details
    ISSN: 1432-0533
    Keywords: Perineurium ; Experimental Allergic Neuritis ; Extravasated Protein ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic observations on the perineurium in EAN are described. Extravasated serum protein was observed in the endoneurial space and also between the cellular laminae of the perineurium. A mechanism of macropinocytotic transport of protein across the perineurium is proposed. The observations are related to the known properties of the perineurium as a diffusion barrier and are interpreted as a mechanism by the perineurium to restore the composition of the endoneurial fluid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691130
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  • 5
    Electronic Resource
    Electronic Resource
    Permeabilitätsstörungen im zentralen Nervensystem des Schweines (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 299-315 
    Details
    ISSN: 1432-0533
    Keywords: Cerebrospinal Angiopathy ; Pig ; Arterial Lesions ; Blood-Brain Barrier ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An electron microscope study of the central nervous system was performed in 5 pigs with cerebrospinal angiopathy. Characteristic lesions in arterioles and small arteries are insudations and necroses in the media with the endothelial cell layer essentially intact. Some smooth muscle cells within the insudate may show transformation into fibroblast-like cells. Due to the proliferation of these cells a new subendothelial cell layer is formed. In venules there are marked plasmarrhagias although the endothelium appears to be normal and the number of pinocytotic vesicles does not increase. In collagen fibrils the cross striation appears unaltered; the diameter of the fibrils varies between 0.05–0.4 μm. Swollen astrocytes around vessels and in the neuropil contain large numbers of osmiophilic spherical or polyhedrical coacervations in their cytoplasm mostly without a limiting membrane. These cytoplasmic inclusions most likely represent blood plasma constituents which may have penetrated from the perivascular space of arterioles and venules into the astrocytes. The morphological substrate of the blood-brain-barrier at the capillary level is altered only rarely. As the cause of porcine cerebrospinal angiopathy, toxins of E. coli are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691748
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  • 6
    Electronic Resource
    Electronic Resource
    Glial reactions induced by treatment with colchicine of the central nervous system of rabbits (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 145-157 
    Details
    ISSN: 1432-0533
    Keywords: Colchicine ; Astroglia ; Oligodendroglia ; Drug-Induced Changes ; Glial Cells ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbits treated with a single intracisternal injection of 100 μg colchicine dissolved in 50 μl water, got signs of neurological disturbances within a day and became quadriparetic in about two days. The glial cells in the brain, the brain stem and spinal cord were examined. Special emphasis was paid to those in the hypoglossal and dorsal vagal nuclei. Many of the astrocytes became hypertrophic after injection of colchicine and got an increased number of filaments and cell organelles, including mitochondria and dense bodies. The oligodendrocytes showed more or less marked changes, including lipid droplets and dense bodies. Several glial cells, rarely noticed in the controls, showed marked signs of reactive changes and did not fulfil the criteria for either astrocytes or oligodendrocytes. The results obtained are discussed in relation to those obtained after other types of treatment of nervous tissue. It is concluded that the glial changes are partly due to effects induced by colchicine, which inhibits the intracellular transport, but not the formation of cell constituents. Emphasis had to be paid to the fact that drug-induced changes in the glial cells may severely alter the metabolism and function of adjacent neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688781
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  • 7
    Electronic Resource
    Electronic Resource
    Herpes virus hominis type 2 and intranuclear tubular structures in organized nervous tissue cultures (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 170-179 
    Details
    ISSN: 1432-0533
    Keywords: Herpes Virus, Type 2 ; Tissue Culture ; Intranuclear Tubules ; Microtubular Structures ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mature explants of mouse spinal cord and ganglia have been infected with Herpes virus hominis type 2. After 48 h, a high titer of virus was detected in the explant and typical herpes-like particles were seen by electron microscopy. They were more numerous in sensory neurons and Schwann cells than in the CNS possibly because of a more rapid propagation through the extracellular space in spinal ganglia. In the infected nuclei, besides the naked particles, numerous tubular formations were found, apparently resulting from virus infection and specific for herpes type 2. Their dimensions and fine structure are illustrated and compared to other microtubular formations. In the cytoplasm of theneurons, a dramatic disorganisation occurred and, in the Schwann cell, the plasma membrane underwent disruption. Consequently, the normal axon — Schwann cell intimate contact was lost.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688783
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  • 8
    Electronic Resource
    Electronic Resource
    Étude clinique, histologique et ultrastructurale de quatre cas de leucodystrophie métachromatique infantile et juvénile (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 23-38 
    Details
    ISSN: 1432-0533
    Keywords: Leucodystrophy Metachromatic ; Electron Microscopy ; Prismatic Deposits ; Brain ; Peripheral Nerve ; Kidney ; Rectum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical history, light and electron microscopy findings are reported in four cases of infantile metachromatic leucodystrophy. By electron microscopy, the authors describe the various types of lesions and the different lipid deposits noticed in the central and peripheral nervous system, in the kidney and rectum. They stress the prismatic lipid deposits observed not only in the cerebral white matter and in the kidney but in the peripheral nerves as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687997
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure of Hirano bodies (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 50-60 
    Details
    ISSN: 1432-0533
    Keywords: Hirano Bodies ; Rod-Like Structures ; Inclusions ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By light microscopy, Hirano bodies are fusiform or spheroidal eosinophilic bodies, that are commonly observed in the hippocampi of the elderly and are especially numerous in patients with various dementias or degenerative diseases. Rarely, they have been demonstrated in other locations and even in animals. Ultrastructurally, the Hirano bodies are complex pleomorphic aggregates of intraneuronal fibrillary material found predominantly in the processes but occasionally in the perikarya. The Hirano bodies are assembled from multiple subunits, but occasionally in the perikarya. The Hirano bodies are assembled from multiple subunits, each consisting of two overlapping or intersecting expanses of parallel filaments. Depending on the plane of section and orientation, the subunit may appear as a lattice-work array of intersecting filaments, a row of regularly spaced punctate densities closely applied to a filament, or a broader feathery fibril. The subunits appear to be derived from the reorganization or precipitation of randomly dispersed finely filamentous material. Because of the diverse circumstance under which they are found, Hirano bodies are regarded as a non-specific manifestation of neuronal degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687999
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  • 10
    Electronic Resource
    Electronic Resource
    Fine-structure of bilateral radionecrosis in the dorsal hippocampus (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 89-98 
    Details
    ISSN: 1432-0533
    Keywords: Ionizing Radiation ; Late Effects ; Brain ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The data with which this paper deals were obtained from white rats receiving limited head X-irradiation, tested for behavioral changes, and sacrificed for light and electron microscopic evaluation 1 year after the irradiation. No evidence was found for a general loss or change in cortical or subcortical neurons. On the other hand, there was bilateral focal degeneration in the fimbria of the fornix in the dorsal hippocampus. This involved considerable numbers of pyramidal and granule cells, presumably secondary to delayed vascular changes. Widespread hypertrophy of astrocytes was noted throughout the irradiated zone. Within each central necrotic zone invasive collagen, reticulin and fibrin were present. In general, blood vessels showed only occasional evidence of thickening. However, the blood vessels in the areas of frank necrosis in the fimbria and internal capsule exhibited intense thickening leading to hyalinization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687563
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  • 11
    Electronic Resource
    Electronic Resource
    The electron microscopic study of the appendix as early diagnostic means in Batten-Spielmeyer-Vogt disease (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 169-175 
    Details
    ISSN: 1432-0533
    Keywords: Batten's Disease ; Electron Microscopy ; Appendix ; Curvilinear Inclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopic findings in the appendix of a five-year-old child suffering from Batten's disease are presented. They revealed accumulations of curviform densities in smooth muscle cells, nerve cells and Schwann cells of the myenteric plexus of Auerbach. Typical lipofuscin pigment was not observed. The presence of transitional forms, however, suggesting progressive transformation of the inclusions into lipofuscin-like granules, is briefly discussed. It is proposed that, during life, electron microscopy of the appendix might be useful for the diagnosis or more specific classification of a form of storage disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687571
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  • 12
    Electronic Resource
    Electronic Resource
    Identification of neuroglia by light and electronmicroscopy (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 7-12 
    Details
    ISSN: 1432-0533
    Keywords: Neuroglia ; Identification ; Light Microscopy ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A simple method is described, using ultrathin sections, by which glial cells of all three types can be identified in the same section without using specialised techniques. Thesame cell can be identified by electronmicroscopy and thus allow for exact correlation of light and electron microscopic features. An outline description of glial types is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687546
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  • 13
    Electronic Resource
    Electronic Resource
    Étude ultrastructurale des modifications du cortex cérébral au voisinage d'un foyer épileptogène à la crême d'alumine (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 11-21 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Epilepsy, Experimental ; Focus ; Aluminium Cream ; Neurone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cats were given injections of 0.01 cc of alumina cream into the cortex of the medial surface, above the distal part of the sulcus cruciatus. Then for a month the animals were “stimulated” by intravenous injections of penicillin. The electron microscopic study revealed: 1. A proximal zone close to the alumina cream; it is an inflammatory focus characterised by the presence of an exudate in which macrophages, plasmocytes and collagen fibres are present. 2. A middle zone: the astrocytes are hypertrophied and fibrous; the neurons exhibit either neurofibrillary degeneration or considerable increase of the number of mitochondria. Hypertrophied astrocytes and “hyperchondriomated” neurons are envisaged as possible indications of disturbances of electrical activity. 3. A distal zone: in this region the alterations of the cortex disappear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687898
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  • 14
    Electronic Resource
    Electronic Resource
    A study of rod-like structures (Hirano bodies) in 240 normal and pathological brains (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 61-67 
    Details
    ISSN: 1432-0533
    Keywords: Rod-Like Structures ; Ammon's Horn ; Electron Microscopy ; Age Incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study of rod-like structures (RLS) was made in 173 pathological and in 67 normal brains. The pathological brains included cases with varied neuropathological conditions: vascular, metabolic, degenerative, infectious, traumatic, neoplastic, etc. The ages of the patients ranged from newborn to 97 years. RLS were found in 152 pathological brains (89%) and in 50 normal brains (75%). RLS were localized in all but one case, in Ammon's horn, specifically in Sommer's sector and in the stratum lacunosum beneath Sommer's sector. There was no correlation between any group of diseases studied and appearance or number of RLS. The number of RLS in Sommer's sector increased with advancing age. In the middle age, ihowever, the stratum lacunosum showed a higher number of RLS. The results of this study idicate that there is no significant relationship between RLS and any pathological condition and therefore that they represent non-specific changes, although a correlation with advancing age is probable. Although RLS appeared to be intracellular, their exact localization was not established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688000
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  • 15
    Electronic Resource
    Electronic Resource
    Feinstrukturelle Alterationen an den Capillaren und Venulen im zentralen Nervensystem des Schweines nach experimentellem Colitoxinschock (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 13-28 
    Details
    ISSN: 1432-0533
    Keywords: Colitoxin Shock ; Blood-Brain Barrier ; Pig ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural alterations of the capillaries and venules in the central nervous system after intravenous application of coli endotoxin were studied in 193–7 weeks-old piglets (conventional, SPF and gnotobiotic). Slight lesions were found in the endothelium of capillaries and venules consisting of focal multiplication of microvilli, pinocytotic vesicles, vacuoles and dense bodies as well as occurrence of leukocytes adhering to the vascular surface being located in the vascular wall. There was severe extravasation in venules and occasionally in capillaries. The intercellular spaces of the neuropil were markedly widened and contained a plasma-like material. An increased number of lysosomes and osmiophilic depots were seen in the neuropil of 4 out of 19 animals resembling the lesions of porcine cerebrospinal angiopathy. Microthrombi, aggregations of platelets and erythrocytes were found in the vascular lumen indicating a disturbance of microcirculation after the application of coli endotoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687547
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  • 16
    Electronic Resource
    Electronic Resource
    Fine structural changes in the sural nerve of patients with acanthocytosis (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 257-263 
    Details
    ISSN: 1432-0533
    Keywords: Acanthocytosis ; Sural Biopsy ; Electron Microscopy ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of sural nerve biopsies is described in two brothers with normo-lipoproteinaemic acanthocytosis and an associated neurological syndrome. There was a severe reduction of myelinated fibres. The Schwann cells had an increased population of lysosomes and contained remnants of myelin. The myelin lamellae were often split at the intraperiod lines. Centrioles were found in Schwann cells, fibroblasts and endothelial cells. The significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684528
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  • 17
    Electronic Resource
    Electronic Resource
    Electron microscopic studies of rabbit central and peripheral nervous system in experimental Borna disease (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 305-318 
    Details
    ISSN: 1432-0533
    Keywords: Encephalitis, Viral, Experimental ; Electron Microscopy ; Nervous System, Central and Peripheral ; Crystalline Aggregates ; Filamentous Collections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The CNS and posterior root ganglia of rabbits experimentally infected with Borna virus were studied by electron microscopy. Intracytoplasmic crystalline arrays were common in the non-neuronal cell elements of the central and peripheral nervous tissues of all infected animals. Peculiar filamentous collections were seen occasionally in the central and peripheral neurons of one third of the inoculated rabbits. Control animals showed no such changes. In the affected tissues the nuclear density was increased. There were numerous cells grouped around the vessels or scattered singly or in clusters in the parenchyma. Amongst them plasma cells could be recognized as well as mononuclear cells of hematogenous origin, microglia cells in various reactive stages and macrophages derived from either of the latter cell types. The nonspecific character of the crystalline aggregates is emphasized. The questionable viral nature of the filamentous bundles is considered briefly; other explanations as to their nature are also mentioned. Finally, attention is drawn to the heterogeneous composition of the glial nodules and to the ultrastructural variability of the various cell types found in the inflamed tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809242
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  • 18
    Electronic Resource
    Electronic Resource
    Giant axonal neuropathy — A unique case with segmental neurofilamentous masses (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 237-247 
    Details
    ISSN: 1432-0533
    Keywords: Neurofilament ; Neuropathy ; Electron Microscopy ; Neurofibrillary Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sural nerve biopsy was performed on a six-year-old girl with a slowly progressive distal mixed polyneuropathy. The nerve fiber population was reduced, and of those remaining, approximately half were greatly enlarged, measuring up to 35 microns in cross section. Longitudinal sections showed axonal enlargement to be segmental. Ultrastructurally, swollen axonal segments were filled with neurofilaments in closely-packed swirls which appeared to tie on occasion into granular electron-opaque condensations. Both, myelinated and unmyelinated fibers were involved, and some degree of onion-bulb formation was observed. Although masses of neurofilaments are found in peripheral axons in other disorders, none approaches the proportions encountered in this unique case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686905
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  • 19
    Electronic Resource
    Electronic Resource
    Effects of Nerve Growth Factor antiserum on peripheral unmyelinated nerve fibers (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 288-298 
    Details
    ISSN: 1432-0533
    Keywords: Nerve Growth Factor ; Peripheral Nerve Fibres ; Schwann Cells ; Electron Microscopy ; Phase Contrast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve Growth Factor (NGF) antiserum causes neuronal loss in the sympathetic ganglia of newborn rats. Pre and post ganglionic sympathetic fibers from eleven such animals and eight controls were studied by phase contrast and electron microscopy. Quantitative techniques were applied to the study of different parameters of the axons and Schwann cells. Treated animals showed only 24% of the axonal population of controls and 34% of Schwann cells. This fiber loss was non-selective, affecting all fiber sizes. Schwann cells from treated animals enclosed fewer axons than normal and some contained none. Contrary to what is seen following transection of an unmyelinated nerve, regenerative axonal sprouting was not observed during the 6 week period studied. Schwann cell processes were elongated and unfolded, frequently engulfing bundles of collagen. NGF antiserum experiments provide a tool for the study of axonal and Schwann cell behaviour after neuronal loss avoiding the disadvantages of the traumatic disruption of neural architecture that results from experimental surgical lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691747
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  • 20
    Electronic Resource
    Electronic Resource
    Glycogen accumulation in spinal cord motor neurons due to partial ischemia (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 335-347 
    Details
    ISSN: 1432-0533
    Keywords: Spinal Cord Ischemia ; Neurons ; Glycogen ; UDPG-transferase ; Glycogen Phosphorylase ; Histochemistry ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Partial ischemia of the spinal cord in adult cats was induced by abdominal aortic ligation. The most striking abnormality was an accumulation of glycogen in large motor neurons and astroglia in the peripheral anterior horns. Little or no histological and ultrastructural abnormalities were present in these regions. The first glycogen deposits appeared after 1/2 h in glial cells, whereas glycogen accumulation in neurons was first noticeable 1 h after ligation reaching a maximum in 24 h. A gradual decrease occurred with disappearance of glycogen at 10 days. Increase in UDPG-transferase was found preceeding glycogen appearance, and increase in glycogen-phosphorylase activity occurred later concurrent with glycogen accumulation. This unique neuronal glycogen deposition may be due to the UDPG-transferase normally present in γ-motor neurons of the anterior horns. Other possible mechanisms are also considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691750
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  • 21
    Electronic Resource
    Electronic Resource
    Microglial reactions following thermal necrosis of the rat cortex: An electron microscope study (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 11-22 
    Details
    ISSN: 1432-0533
    Keywords: Microglia ; Cerebral Cortex ; Cold Lesion ; Electron Microscopy ; Phagocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural appearances of microglia in the rat cerebral cortex were examined following experimental cold lesions. It was found that microglia toop up extravascularized plasma by pinocytosis. These pinocytotic vesicles coalesced to form large vacuoles of medium electron density, which subsequently decreased in size and increased in density and morphological complexity. Concurrently the microglial cells underwent dedifferentiation and division. Between 3 and 7 days after making the cold lesion it was difficult to distinguish between phagocytes of microglial and haematogenous origin. The relationship of microglia to haematogenous phagocytes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687996
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  • 22
    Electronic Resource
    Electronic Resource
    Light and electron microscopic studies of experimental hydrocephalus (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 213-223 
    Details
    ISSN: 1432-0533
    Keywords: Hydrocephalus, Experimental ; Cats ; CSF Turnover ; Ependyma ; Subependymal Tissue ; Extracellular Space ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A light and electron microscopic study of the ependymal and subependymal regions of experimental hdrocephalic cats was made. Hydrocephalus was induced by injection of kaolin into the cisterna magna. Cerebrospinal fluid (CSF) turnover was measured in all experimental cats by ventricular perfusion just prior to glutaraldehyde fixation. The cats were sacrificed at 7 (acute hydrocephalus) and at 21 or more days (chronic hydrocephalus) after kaolin. The major pathological findings were: flattened and outstretched ependymal lining, detachment of ependymal cells and rarefaction of subependymal areas with increase in the extracellular space. The significant morphological alterations in acute hydrocephalus, characterized by a marked decreased rate of CSF absorption, were flattening and outstretching of ependymal cells with minimal rarefaction of subjacent tissues. In the acute animal with a measurable amount of CSF absorption, and more clearly, in the chronic animal with higher rates of CSF absorption, detachment of ependymal calls, significant rarefaction of subependymal tissues, and marked increased subependymal extracellular space were the predominant changes. It is concluded that these pathological changes provide the morphologic substrate for transventricular absorption of CSF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688500
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  • 23
    Electronic Resource
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    Coiled nucleocapsid configuration in subacute sclerosing panencephalitis (SSPE) (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 263-271 
    Details
    ISSN: 1432-0533
    Keywords: Subacute Sclerosing Panencephalitis ; Electron Microscopy ; Nuclear Bodies ; Tubular Inclusions ; Nucleocapsids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this case of documented subacute sclerosing panencephalitis (SSPE), electron microscopy of a brain biopsy revealed a previously unreported “fingerprint” configuration of tubular inclusions or nucleocapsids. The pattern resembled that of the whorled filamentous nuclear bodies which are so frequently encountered in ultrastructural studies of this disease. Furthermore, an apparent tubule was seen running parallel to filaments within the nucleus of still another affected cell. These findings lend support to the concept that nuclear bodies are converted into and/or synthesize nucleocapsids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685134
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  • 24
    Electronic Resource
    Electronic Resource
    Aspects ultrastructuraux du corps calleux chez la souris Jimpy (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 282-295 
    Details
    ISSN: 1432-0533
    Keywords: Jimpy Mouse ; Electron Microscopy ; Neuroglia ; Mouse Mutant ; Myelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Corpus callosum of Jimpy mouse brain was investigated with the electron microscope in 14, 21, 29 days old animals, and compared with that of normal littermates. Myelination was almost lacking in Jimpy; this absence seems to be due to an agenesis rather than a destruction. The oligodendrocyte cell line is severely disturbed; adult oligodendrocytes are absent in all the animals studied, even in 29 days animals. The few oligodendrocytes present are young; they are found in the vicinity of the few myelinated fibers. Features suggestive of oligodendrocyte death were found both in corpus callosum and neighbouring cortex. The astrocyte cell line develops normally; evidences of cell reactivity such as increase of glycogen and gliofilaments were found. Microglia were present in large numbers and contained several types of inclusions, whose signification is discussed. It is concluded that the defect of myelination in Jimpy mice is closely related to abnormalities found in the oligodendrocyte line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685136
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  • 25
    Electronic Resource
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    Glycogen reaction to cerebral stab wound during maturation of rat brain (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 158-169 
    Details
    ISSN: 1432-0533
    Keywords: Brain Stab Wound ; Glycogen Reaction ; Histochemistry ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Abnormal accumulation of glycogen around cerebral stab wounds was studied histochemically, electron microscopically, and quantitatively in rats 4, 13, 28 days old and in adult (90–150 days old) animals. Glycogen did not accumulate around stab wounds in 4 and in 13-day old rats, whereas a considerable accumulation of glycogen was present in the 28 day and in adult animals. There was a close parallelism between the amount of glycogen accumulated and the degree of maturation of oxidative enzyme activity as reflected by succinic dehydrogenase activity in the cortex. In 28 day and in adult animals, a pale central necrotic core was surrounded by a zone of reduced enzyme activity. The region of glycogen accumulation was located peripherally to this zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688782
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  • 26
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    Electron miscroscopic and enzyme histochemical studies of the cerebellum in spongy degeneration (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 22-31 
    Details
    ISSN: 1432-0533
    Keywords: Spongy Degeneration ; Cerebellum ; Electron Microscopy ; Enzyme Histochemistry ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic and enzyme histochemical studies were performed on the cerebellum from a 9 month old Jewish boy with spongy degeneration. Histologically, the main pathological changes were noted in the Purkinje cell layer, the deeper areas of the granular cell layers and the subcortical white matter. Ultrastructurally, multiple vacuoles were present within the swollen cytoplasm and processes of protoplasmic astrocytes in the cortex, while in the subcortical white matter vacuoles were observed within splitting myelin lamellae as well as within astrocytes. There were also abnormal mitochondria within swollen protoplasmic astrocytic cytoplasm and processes which in ATPase preparations showed little or no reaction product. However, the fibrillary astrocytes were not swollen and contained intact mitochondria which showed normal reaction product in ATPase preparations. Since the myelin changes are known to be nonspecific and secondary to abnormal fluid accumulation, the characteristic distribution of the multiple vacuoles in the central nervous system in this disorder seems primarily to be related to swelling of the protoplasmic astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687899
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  • 27
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    Schilder's diffuse sclerosis: A biochemical and ultrastructural study of myelinoclastic demyelination (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 85-95 
    Details
    ISSN: 1432-0533
    Keywords: Lipid Composition ; Axonal Loss ; Ganglioside Deficit ; Schilder's Disease ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of Schilder's diffuse sclerosis with a four-year history of progressive neurologic deterioration in a boy dying at ten years of age is reported. The asymmetry of the process was indicated during life by the clinical findings. A unicentric focus of demyelination was found with the initial stages in the occipital and temporal white matter and a subacute reaction in the rostral cerebral white matter, brain stem, and cerebellum. Electron microscopic study confirmed the extensive axonal loss. No particles compatible with a virus structure were identified. Analysis of the regional composition of cerebral lipids demonstrated large deficits of cerebroside, sulfatide, cholesterol, total phospholipid, sphingomyelin, and ganglioside in the occipital lesion. A significant but less complete deficit of lipids was found at the lesion margin in frontal white matter. An increase of cholesterol esters was demonstrated at this site as well. The normal-appearing white matter of rostral frontal lobe showed a decreased level of ganglioside and normal concentrations of the other structural lipids. This decreased ganglioside concentration of grossly normal white matter suggest the advisability of considering Wallerian degeneration in interpreting the analytical data obtained in the study of the demyelinating disorders. The morphological and biochemical findings indicate the progressive spread of the axonolytic and myelinolytic process in the pathogenesis of Schilder's diffuse sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691126
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  • 28
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    Ultrastructural studies of the nervous system after mercury intoxication (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 122-138 
    Details
    ISSN: 1432-0533
    Keywords: Mercury Intoxication ; Nerve Cells ; Dorsal Root Ganglion ; Cerebellum ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When given to rats, both organic and inorganic mercury compounds were found to be neurotoxic. After CH3HgCl intoxication, focal cytoplasmic degradation was the most characteristic lesion observed in the neurons of the dorsal root ganglion. A large cytoplasmic vacuole was formed in many neurons as a result of such lesions. After HgCl2 poisoning, the dorsal root ganglion neurons developed peripheral vacuoles, which were formed by the retraction of the neuron from its surrounding satellite cells. Extensive fragmentation of these neurons occurred as such vacuolation progressed. Multiple small lesions varying from 0.1–1.2 μ were found in the neuronal cytoplasm after both organic and inorganic mercury intoxication. Mercury could be demonstrated histochemically to have a close association with these lesions. In the anterior horn motoneurons, neither mercury compound produced any permanent pathological lesions in the nerve cell bodies, although there was severe dilatation of the cisternae of the endoplasmic reticulum and the nuclear envelope at early stages of the intoxication. In the cerebellum, both organic and inorganic mercury compounds produced extensive coagulative or lucid changes in the granule cells. Degeneration of the Purkinje cells was also found at late stages of the poisoning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691129
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  • 29
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    Ultrastructure of the onion bulb-like lamellated structure observed in the sural nerve in a case of von Recklinghausen's disease (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 258-263 
    Details
    ISSN: 1432-0533
    Keywords: Electron Microscopy ; Sural Nerve ; von Recklingshausen's Disease ; Schwann Cell ; Onion Bulb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Examination of photo and electron microscopical preparations of a biopsied sural nerve from a patient with von Recklinghausen's disease is reported. In the toluidine blue stained Epon-sections the number of myelinated fibers per square millimeter was moderately decreased and the number of large myelinated fibers was severely reduced. Large, circular, lamellated structures which resemble the onion bulb were observed. These structures are different from the previously reported onion bulb in their size and core structure which contains usually a degenerated nerve fiber. Some consideration was given to the origin of these onion bulb-like lamellated structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686907
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  • 30
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    An ultrastructural analysis of remyelination following segmental demyelination (1972)
    Springer
    Acta neuropathologica 22 (1972), S. 333-344 
    Details
    ISSN: 1432-0533
    Keywords: Segmental Demyelination ; Remyelination ; Axon/Schwann Cell Relationship ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopic observations were made of early remyelination after segmental demyelination in experimental allergic neuritis (EAN) and experimental diphtheritic neuropathy. In EAN 71% of axons which had been demyelinated were invaginated each within a single Schwann cell; remyelination associated with this cellular relationship was in accordance with the spiral myelin concept, 29% of demyelinated axons in EAN were initially enveloped each by several Schwann cell processes and the associated mechanism of remyelination was by “tunication” resulting in a transient irregular distribution of myelin lamellae around the axon circumference. In diphtheritic neuropathy regeneration more closely paralleled development in ontogeny. 88% of demyelinated axons were invaginated each within one Schwann cell, only 12% of axons were each enveloped by more than one Schwann cell process. Early remyelination by tunication was not observed in diphtheritic neuropathy. Additional loosely associated Schwann cell processes lying within the “old” Schwann cell basement membrane occurred frequently in both experimental conditions. Schmidt-Lanterman clefts, “redundant” myelin, and “desmosomes” were observed in the sheaths of incipient remyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809244
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    Human blood platelets as cellular models for investigation of membrane active drugs: Beta-adrenergic blocking agents (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 275 (1972), S. 299-313 
    Details
    ISSN: 1432-1912
    Keywords: Human Blood Platelets ; Inhibition of Serotonin Uptake ; Lipid Solubility ; Beta-Adrenergic Blocking Agents ; Serotonin Release ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Beta-adrenergic blocking agents inhibit serotonin uptake by human blood platelets; in addition they induce release of the previously accumulated amine in vitro. Propranolol was the most active drug, followed by alprenolol, Kl 255, Kö 592, INPEA, oxprenolol, pindolol, Kö 1366, practolol, and sotalol. Kinetic analysis revealed a mixed type of inhibition of serotonin uptake. A significant correlation between these parameters and the lipid solubilities of the respective drugs was found. In contrast to the active serotonin uptake labelled β-sympatholytics were accumulated by the platelets passively, i. e. independently of temperature and of time of incubation. The degree of accumulation by human blood platelets and human erythrocyte ghosts was again correlated with the hydrophobicity of the compounds. Therefore, it is concluded that these effects of β-adrenergic blocking agents are mainly unspecific in nature, depending on the lipid solubility of the drugs, and leading to conformational changes within the membranes. This assumption is supported by the electron microscopical findings in human platelets, indicating ultrastructural changes and cell lysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500058
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  • 32
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    Pinocytose und Bewegung von Amöben (1972)
    Springer
    Cell & tissue research 127 (1972), S. 270-286 
    Details
    ISSN: 1432-0878
    Keywords: Endocytosis ; Locomotion ; Membrane turnover ; Hyalodiscus simplex ; Morphometry ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Hyalodiscus simplex zeigt während der normalen Fortbewegung eine auf den Uroidbereich beschränkte permanente Endocytoseaktivität, durch die kontinuierlich Zellmembran und extrazelluläres Milieu ins Innere der Zelle aufgenommen wird. Nach unter-schiedlich langer Inkubation in einer 2.5% igen Thorotrastlösung kann die Markierungssubstanz bei ihrer Passage durch die Zelle morphologisch verfolgt werden. Das endocytierte Thorotrast gelangt in ein intrazelluläres Membransystem, welches für die Verdauung verantwortlich ist und dessen Gesamtoberfläche in der Größenordnung der Zelloberfläche liegt. Verschiedene, funktionell miteinander in Verbindung stehende Vakuolen stellen die charakteristischen Komponenten des intrazellulären Verdauungssystems dar. Die morphometrische Auswertung der Markierungsversuche hat gezeigt, daß der Membran-Turnover etwa 2% pro Minute beträgt. Hyalodiscus simplex benötigt demnach bei normaler Lokomotion zur vollständigen Regeneration der Zellmembran eine Zeit von 7,5–8 Std. Da die Oberfläche trotz permanenter Endocytoseaktivität auch nach unterschiedlich langer Thorotrastinkubation stets konstant bleibt, darf vermutet werden, daß die endocytotisch aufgenommene Zellmembran durch einen noch unbekannten Mechanismus wieder regeneriert wird.
    Notes: Summary During locomotion Hyalodiscus simplex is active in permanent endocytosis at the uroid region. Thereby plasma membrane and extracellular medium are translocated into the cell interior. After different periods of incubation in a 2.5% solution of thorotrast the tracer can morphologically be followed during the passage through the cell. The ingested thorotrast is collected within a vacuolar system. This system is involved in intracellular digestion and composed of different types of vacuoles, which are structurally separated but functionally interconnected. Its total surface area approximately corresponds to the surface area of the entire cell. As demonstrated by morphometric analysis, the membrane turnover is about 2% per minute. Therefore, in the migrating amoebae 7.5–8 hours are required for the complete regeneration of the plasma membrane. Since the surface area of the cell remains constant despite of permanent endocytotic activity the ingested plasma membrane must be continuously regenerated by an unknown mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306808
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  • 33
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    Über die Lymphkapillaren in den Darmzotten von Meerschweinchen und Affe (1972)
    Springer
    Cell & tissue research 133 (1972), S. 551-557 
    Details
    ISSN: 1432-0878
    Keywords: Lymphatic capillaries ; Intestinal villus ; Muscularis mucosae ; Guinea pig, Monkey ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die zentralen Chylusgefäße in den Zotten des Duodenum und Jejunum von Meerschweinchen und Affe zeigen die Strukturbesonderheiten, die für die Lymphkapillaren des Dünndarms charakteristisch sind. Die Endothelzellen sind durch ihre langen Ausläufer in komplizierter Weise miteinander verzahnt. Sie können an diesen Stellen auseinanderweichen und größeren Chylomikronen den Durchtritt vom extrazellulären Raum in die Lymphkapillaren ermöglichen. Marklose Nervenfasern und vor allem glatte Muskelzellen der Muscularis mucosae treten mit dem Endothel der Lymphkapillaren in Kontakt. Das Zusammenwirken der Endothelverzahnungen mit der Zottenpumpe, die auf den Kontraktionen der glatten Muskelzellen beruht, wird im Hinblick auf den Lymphtransport diskutiert.
    Notes: Summary The central lacteals in the villi of duodenum and jejunum (Macaca mulatta, Cavia cobaya) exhibit the same structural peculiarities as the lymphatic capillaries in the villi of the small intestine in general. The endothelial cells overlap extensively at their margins. At these points they may be separated from each other so enabling larger chylomicra to pass from the extracellular space into the lumen of the lacteal. Nonmyelinated nerve fibres as well as smooth muscle cells of the Muscularis mucosae in particular contact the endothelium of the lymphatic capillaries. The co-operation of the endothelial interdigitations with the villus pump, realized by the contractions of the smooth muscle cells, is discussed as mechanism of the lymph transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307135
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    Identification of adenohypophysiotropic neurohormone producing neurosecretory cells in Rana temporaria (1972)
    Springer
    Cell & tissue research 134 (1972), S. 459-504 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamus (Frog) ; Tubero-hypophysial system ; Neurosecretory cell types ; Releasing factors ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopic investigation of neural isolated and normal pars ventralis of the tuber cinereum showed the presence, in Rana temporaria, of a tubero-hypophysial neurosecretory system. A striking structural resemblance between this parvicellular, aldehydefuchsin negative, tubero-hypophysial neurosecretory system and the magnocellular, aldehydefuchsin positive, hypothalamo-hypophysial neurosecretory system was observed. Six different neurosecretory cell types are described, characterized by different shape and size of their respective secretory granules. The nature of the secretory product of these cells is briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307669
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  • 35
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    Zur Relativen Reaktivität der Epoxid- und Halogengruppe in Epihalogenhydrinen bei der basenkatalysierten Reaktion mit Hydroxyverbindungen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 71-79 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die basenkatalysierte Reaktion von Epihalogenhydrinen mit Hydroxyverbindungen kann theoretisch primär unter Aufspaltung des Epoxidringes (Weg I), Substitution des Halogens (Weg II) oder gleichzeitig nach I und II ablaufen. Versuche mit [3-14C] markierten Epihalogenhydrinen und verschiedenen Hydroxyverbindungen zeigen, daß der Reaktionsverlauf uneinheitlich ist und stark von den Reaktionsbedingungen abhängt; wäßriges alkalisches Medium begünstigt Weg I, wasserfreies Weg II. Der Temperatureinfluß ist im Bereich von 25° bis 75° gering.Phenol z. B. reagiert in wäßriger Natronlauge bei 25° sowohl mit Epichlor- als auch Epibromhydrin fast quantitativ gemäß I. Bei 75° tritt Substitution bei Epichlorhydrin zu 5%, bei Epibromhydrin zu 10% ein; in wasserfreiem Medium steigt der Substitutionsanteil bei Epichlorhydrin auf 11%, bei Epibromhydrin auf 69%.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140110
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  • 36
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    Dehydrierung von Ketonen mit Palladium(II)-VerbindungenHerrn Prof. Dr. Dr. h. c. mult. Alfred Rieche in Verehrung und Dankbarkeit zum 70. Geburtstag gewidmet (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 170-180 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cyclohexanon reagiert mit Palladium(II)-Verbindungen in einer stöchiometrischen Reaktion unter Dehydrierung zum Cyclohexen-(2)-on. Diese Dehydrierungsreaktion ist allgemein auf Ketone anwendbar. Der Mechanismus der Reaktion wird diskutiert.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140121
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  • 37
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    Über die Alkylierung 1-substituierter Pyrazolidone-(3) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 220-228 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1-Alkyl- und 1-aralkylsubstituierte Pyrazolidone-(3) liefern mit Alkylhalogeniden und -tosylaten cyclische Hydraziniumsalze 3, die mit Basen in resonanzstabilisierte N⊕, N⊖ - Betaine 5 überführbar sind. Die Strukturen 3 und 5 werden durch kritische Diskussion von IR- und 1H—NMR-Spektren sowie chemisch eindeutig festgelegt.1-Methyl-1-benzyl-pyrazolidon-(3)-N,N,-betain 5h wird thermisch in 1-Methyl-2-benzyl-pyrazolidon-(3) 7h umgelagert („WAWZONEK-Umlagerung“). Die thermische Spaltung von 1-Methyl-1-(1-methyl-phenäthyl)-pyrazolidon-(3)-N,N-betain 5l ergibt 86% trans- und 14% cis-β-Methyl-styrol („azaanaloge Ylid-Eliminierung“).
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140204
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  • 38
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    Kationische Farbstoffe und Vorstufen. IX.VIII. Mitt.: H. HARTMANN u. F. MOHN, J. prakt. Chem. 313, 737 (1971). Darstellung von Cyaninen der 1,2- und 1,3-Dithiol-Reihe (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 240-250 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ausgehend von methyl- bzw. benzylsubstituierten 1,2- und 1,3-Dithiolium-Salzen wurden Versuche zur Herstellung von Trimethin- und Styryl-Cyaninen unternommen. Von diesen ließen sich vor allem die Styryl-Cyanine leicht synthetisieren.Aus einigen experimentellen Besonderheiten ergaben sich Folgerungen für den möglichen Reaktionsverlauf der Cyaninbildung.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140206
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  • 39
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    Reactions with 2,4-Dimethyl-butadiene-(1,3)-sultone-(1,4) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 367-370 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140219
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  • 40
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    Kristallstruktur von Demissidin-hydrojodid (C27H45NO·HJ· 0,5 C2H5OH) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 371-376 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140220
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  • 41
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    Kinetische Untersuchungen über die Methoxymercurierung offenkettiger aliphatischer Olefine (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 285-295 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Nach der Methode der Konkurrenzreaktion wurden für 28 offenkettige aliphatische Olefine die relativen Geschwindigkeiten der Umsetzung mit Quecksilberacetat in Methanol bestimmt. Die kinetischen Daten lassen sich mit der TAFT-Gleichung korrelieren. Der Wert σ* = -1,00 ist für eine elektrophile Olefin-Addition ungewöhnlich wenig negativ; da gleichzeitig δ = 0,91 ist, ergibt sich die Sonderstellung der Methoxymercurierung auf Grund des gegenüber anderen Olefin-Additionen viel höheren Beitrags sterischer Effekte zur Reaktivität. Die Auswertung der Methoxymercurierungsgeschwindigkeiten mit Hilfe einer fünfparametrigen TAFT-Gleichung liefert Argumente dafür, daß der Übergangszustand einem unsymmetrisch verbrückten Mercuroniumion ähnlich ist. Auch bei anderen elektrophilen Olefin-Additionen kann der fünfparametrige Ansatz verwendet werden, um Feinheiten des Reaktionsmechanismus zu erkennen.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140211
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  • 42
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    Synthese N-substituierter Aminosaccharosederivate (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 365-366 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140218
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  • 43
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    Kernresonanzuntersuchungen an AzaindolizinenAbweichend von den IUPAC-Regeln 1957 wird in diesem Beitrag des logischen Zusammenhangs wegen die „Aza“-Nomenklatur mit Indolizin als Stammheterocyclus verwendet. Die korrekten Namen der untersuchten Heterocyclen sind in den Tab. 2, 4 und 5 in Klammern aufgeführt. (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 515-524 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Zwischen der chemischen Verschiebung bestimmter Protonen in unsubstituierten Azaindolizinen und den quantenchemisch berechneten π-Elektronendichten am benachbarten C-Atom wird ein linearer Zusammenhang gefunden. Diese lineare Abhängigkeit gilt auch für substituierte 1,3,4-Triazaindolizine. Die von den Substituenten hervorgerufenen Veränderungen der chemischen Verschiebung der Ringprotonen korrelieren weiterhin gut mit den HAMMETTschen σp-Substituentenkonstanten.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140317
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  • 44
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    Zur Reaktion von 2-Chlorvinylcarbonylverbindungen mit Thioglycolsäureester (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 499-506 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2-Chlorvinylcarbonylverbindungen reagieren mit Thioglycolsäureäthylester unter Substitution des Chloratoms. Die dabei aus 2-Chlorvinylaldehyden resultierenden 2-(Äthoxycarbonylmethylmercapto)-vinylaldehyde cyclisieren unter den Reaktionsbedingungen sofort zu substituierten Thiophen-2-carbonsäureäthylestern. Demgegenüber können aus 2-Chlorvinylketonen 2-(Äthoxycarbonylmethylmercapto)-vinylketone erhalten werden. Diese Substitution verläuft nicht stereospezifisch. Die Produkte lassen sich ebenfalls zu Thiophen-2-carbonsäureestern cyclisieren.
    Additional Material: 7 Tab.
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    URL: http://dx.doi.org/10.1002/prac.19723140315
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  • 45
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    Über α-substituierte Phosphonate. XIV. Phosphorylderivate aus 2,2-Bis-[hydroxymethyl]-norbornen-(5) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 532-542 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2,2-Bis-[hydroxymethyl]-norbornen-(5) 5 läßt sich in bekannter Weise in Cyclische Derivate der phosphorigen Säure, wie z. B, das Diesterchlorid 6, den Triester 8a oder den Diester9 überführen; 6, 8a bzw. 9 wurden in verschiedener Weise weiter umgesetzt. Zum Unterschied von anderen cyclischen Phosphorigsäureestern reagiert 8a unter den Bedingungen der ARBUSOV- bzw. PERKOV-Reaktion mit verschiedenen C-Halogenverbindungen ausschließlich ohne Ringöffnung zu cyclischen Phosphonsäurederivaten, vermutlich wegen der Hinderung desnucleophilen Angriffs auf die Neopentyl-analogen CH2-Gruppen des Dioxaphosphanrings.  -  Die dargestellten Dioxan- bzw. Dioxaphosphanderivate liegen nach Ausweis der NMR-Spektren als Stereoisomerengemische vor.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140319
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  • 46
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    Aromatische Stickstofflostverbindungen, abgeleitet von β Aminoketonen, γ-Aminoalkoholen und γ-Aminopropenen, als potentielle Cancerostatica (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 577-591 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Aminomethylierung von o-[(2-Chloräthyl)-amino]-acetophenon 10, m- und p-[Bis-(2-chloräthyl)-amino]-acetophenon 9 und 8 mit Formaldehyd und sekundären Aminen werden MANNICH-Basen gewonnen. Die Reduktion der β-Aminoketone mit Lithiumalanat oder Natriumboranat führt bei p-Derivaten zu N,N-disubstituierten trans-3-Amino-1-{p[bis-(2-chloräthyl)-amino]-phenyl}-propen-(1), bei m-Derivaten zu N,N-disubstituierten 3-Amino-1-{m-[bis-(2-chloräthyl)-amino]-phenyl}-propanolen-(1). Über die cancerostatische Wirkung auf Transplantationstumoren wird kurz berichtet.
    Additional Material: 5 Tab.
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    URL: http://dx.doi.org/10.1002/prac.19723140323
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  • 47
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    Die relativen Geschwindigkeiten für den sauer katalysierten Wasserstoffisotopenaustausch von substituierten Benzolen, Thiophen, Furan, Selenophen und Pyrrol (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 603-611 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Geschwindigkeiten der Protodedeuterierung wurden in einer Methanol (61 Gew.-%)-Wasser (49 Gew.-%)-Mischung in Gegenwart von Schwefelsäure als Katalysator untersucht. Die Konzentrationsänderung wurde IR-spektroskopisch bestimmt.Alle Reaktionen verliefen nach pseudo-1. Ordnung.Für die einzelnen Verbindungen konnten folgende σ+-Werte bestimmt werden:Thiophen (σ2+ = -0,83; σ3+ = -0,45), Furan (σ2+ = -0,86; σ3+ 〉 -0,75), Selenophen(σ2+ = -0,95; σ3+ 〉 -0,53), Pyrrol (σ2+ = -1,7; σ3+ = -1,71). Für den Wasserstoff am C-3-Kohlenstoff im Furan und Selenophen kann nur die obere Schwelle der Austauschgeschwindigkeit angegeben werden, da Hydrolyse bzw. Zersetzung der Ringe einsetzt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140325
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  • 48
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    Electronic Resource
    Masthead (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972) 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140501
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  • 49
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    Additivity of Substituent Effects in the reaction of phenacyl bromide with aromatic amines in ethanol (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 780-784 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rate constants and the kinetic parameters of the reaction of phenacyl bromide with mono and disubstituted anilines in ethanol have been determined. The substituent effects on the free energy of activation have been found to be additive. HAMMETT equation for multiple substitution was applied to correlate reactivity with structural parameters. The substituent effect is separated into inductive and resonance effects.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140510
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  • 50
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    Reactions with 5-Substituted Isorhodanines. I (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 799-805 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Treatment of 5-arylideneisorhodanines 1 with GRIGNARD reagents, effects addition of the reagent to the double bound of the lateral chain to yield products, proved to have structure 2.The thiono group in 1 and 2 condenses with aniline to yield the corresponding 5-substituted-4-phenylimino-2-thiazolidinones 3 and 4.Alkylation of 1 and 2 with alkyl halides or with ethereal diazomethane results in the formation of the S-alkyl derivatives 5 and 6, respectively.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140513
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  • 51
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    Reaction of 1-Methylmercapto-3(4H)-isoquinolone and ethylene diamine. Reactivity of the product towards diazo-compounds, nitrosocompounds, bromine and aromatic aldehydes (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 827-832 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Treatment of 1-methylmercapto-3(4H)-isoquinolone with ethylene diamine gave 4-oxo-2.3.4.5-tetrahydro-imidazo[2,1-a]isoquinoline 5, which on treatment with aryldiazonium chlorides, yielded the azo compounds 6a-f. 5 was found to react with p-nitrosodimethyl aniline to give the anil 8. Compound 5 when treated with bromine, gave the dibromo-derivative 9 which was converted to 8 by treating it with p-dimethylamino aniline. 5 condensed with aromatic aldehydes to give 10a-d.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140517
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  • 52
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    Effect of substitution on reactivity of some alkyl halides in the reaction with sodium thiosulphate (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 822-826 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A comparison of the rate of displacement of halide ion by thiosulphate ion in alkyl halides, namely n-amyl iodide, n-hexyl iodide, n-heptyl iodide, n-octyl iodide, n-amyl bromide, isoamyl bromide, sec-amyl bromide and n-amyl chloride at different temperatures and in varying alcohol-water mixtures has been made. In the case of n-amyl halides, there is a much larger rate difference between chloride and bromide than between bromide and iodide.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140516
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  • 53
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    Reaktion der Azlactone mit Aminoverbindungen. V. Darstellung und Struktur einiger 3,5-disubstituierter 6-Hydroxy-1,2,4-triazine (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 851-856 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Spaltung der ungesättigten Azlactone 1a-i mittels Hydrazinhydrat entstehen die Hydrazide der entsprechenden substituierten α-Acylamino-acrylsäuren 2a-i, die glatt zu den 3,5-disubstituierten 6-Hydroxy-1,2,4-triazinen 3a-i cyclisiert werden.Es wurden NMR- und IR-Spektren von 3 gemessen, um zur Aufklärung ihrer Struktur beizutragen.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140520
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  • 54
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    1-(m-Aminophenyl)-1 H-pyrazolo[3,4-b]chinoxalin-Derivate [1-(m-Aminophenyl)-flavazol-Derivate] von Zuckern der Isomaltose-, Maltose- und Cellobiose-Reihe (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 877-883 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1-(m-Aminophenyl)-1H-pyrazolo[3,4-b]chinoxalin-Derivate [1-(m-Aminophenyl) -flavazol-Derivate] von Zuckern der Isomaltose-, Maltose- und Cellobiose-Reihe wurden durch katalytische Hydrierung der entsprechenden Nitroverbindungen erhalten. Ihre Reindarstellung erfolgte durch Papierchromatographie und Sephadex-Gelfiltration, ihre Charakterisierung durch die RF-Werte, die pH-abhängigen Extinktionsmaxima in den UV-Spektren und IR-spektroskopische Untersuchungen.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140523
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  • 55
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    Reactions with 4,5-Disubstituted 2-Mercaptoimidazoles and their derivatives (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 785-792 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 4,5-Disubstituted 2-mercaptoimidazoles react with chloroacetic acid to form S-carboxy-methyl derivatives, which readily cyclise to the corresponding 2,3-dihydro-imidazo[2,1-b]-thiazol-3-ones. Substituted amides of 2-imidazolylthioacetic acids have now been obtained by the action of amines on the latter compounds.The 2-arylidene and 2-arylazo derivatives of 2,3-dihydroimidazo[2,1-b]thiazol-3-ones are prepared. The action of GRIGNARD reagents on the 2-arylidene derivatives results in addition to the exocylic double bond.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140511
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  • 56
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    Reaktion substituierter Hydrazone mit Phosphortrichlorid (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 806-814 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arylhydrazone von Methylalkylketonen reagieren mit Phosphortrichlorid zu 4-Alkyl-2-aryl-1,2,3-phosphadiazolen 1, deren Struktur durch NMR-, IR-, Raman- und UV-Spektren sowie elektronographisch gesichert wurde. Analog verlaufen die Reaktionen von Acetaldehyd-phenylhydrazon und Aceton-(2-cyanäthyl)-hydrazon mit PCl3.Aceton-acetylhydrazon ergibt mit PCl3 1-Chlor-4-methyl-3-acetyl-1,5-dihydro-1,2,3-phosphadiazol 3, das mit Triäthylamin 4-Methyl-2-acetyl-1,2,3-phosphadiazol 4 bildet. Mit Alkoholen werden aus 3 1-Chlor-4-methyl-2-acetyl-1,5-dihydro-phosphadiazole 5, mit Aminen 4-Methyl-2-acetyl-1-aryl(alkyl)amino-1,5-dihydro-1,2,3-phosphadiazole 6 erhalten.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140514
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  • 57
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    Über Sulfonylierte (β-Cyan-äthyl)-hydrazineHerrn Prof. Dr. Dr. h.c. mult. A. Reiche mit den besten Wünschen zum 70. Geburtstage gewidmet (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 833-839 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: (β-Cyan-äthyl)-hydrazin wird am substituierten N-Atom sulfonyliert. Seine 1,2,2-Tris-sulfonyl-Derivate entstehen aus 3-Imino-pyrazolidin und Arylsulfochloriden in Gegenwart des R—SO2⊕-Überträgers Trimethylamin. Mit Alkohol werden sie exotherm abgebaut, wobei drei Typen von S—N-Spaltreaktionen ablaufen: SN2-Abspaltung von R—SO2—OEt, β- und α-Eliminierung von Sulfinat (R—SO2Na) sowie die bisher nicht bekannte Eliminierung von Sulfinsäureester (R—SO-OEt). Auf Grund der Produktanalyse und von Analogie-reaktionen wird der Abbaumechanismus diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140518
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  • 58
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    Zum Mechanismus der Kationischen Polymerisation des Vinylisobutyläthers mit Jod als Katalysator (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 1-14 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die jodkatalysierte Polymerisation des Vinylisobutyläthers bei tiefen Temperaturen wird mit der Methode der Hochfrequenztitration sowie auch UV-spektroskopisch untersucht. Der während der Polymerisation beobachtete Leitfähigkeitsverlauf läßt auf ein “pseudokationisches” Verhalten schließen. An Hand der erhaltenen Ergebnisse wird ein Mechanismus formuliert, der auf der Annahme eines Gleichgewichtes zwischen freien Ionen und einem cyclischen Übergangskomplex mit weitgehendem Ladungsausgleich basiert.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140102
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    MO-LCAO-SCF-Berechungen von Vinylverbindungen nach dem CNDO/2-Verfahren. Quantenchemische Interpretation der Spektralparameter und des Copolymerisationsverhaltens (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 43-54 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Von Vinylverbindungen CH2=CH—X werden CNDO/2-Elektronendichten und -Bindungsordnungen berechnet und mit entsprechenden spektralen Parametern (13C-NMR-chemische Verschiebungen, 13C—H-Kopplungskonstanten sowie geminale und vicinale H—H-Kopplungskonstanten, integrale Intensitäten der C=C-Valenzschwingung) und reaktionskinetischen Daten (Q- und e-Werte des ALFREY-PRICE-Schemas) verglichen. Die Güte der erhaltenen Korrelationsbeziehungen und die Ursachen von systematischen Abweichungen werden diskutiert.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140107
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    Untersuchung der Photolyse und Thermolyse von o-Chinondiaziden des s-Triazolo[4,3-b]pyridazins (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 55-65 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Diazotierung der leicht zugänglichen 6-substituierten 7-Amino-8-hydroxy-s-triazolo[4,3-b]pyridazine mit Natriumnitrit in Salzsäure erhält man die sehr stabilen 7-Diazo-8-oxo-s-triazolo[4,3-b]pyridazine.Die Photolyse dieser Verbindungen in verd. Salzsäure liefert in einer SÜS-Umlagerung die leicht decarboxylierbaren 6-substituierten Pyrazolo[3,2-c]s-triazol-7-carbonsäuren, in Alkohol die entsprechenden Carbonsäureester. Die Struktur dieser neuen Verbindungsklasse wird IR- und NMR-spektroskopisch bewiesen. Der Einfluß der Temperatur und des Substituenten in 6-Stellung auf die Photolysegeschwindigkeit ist gering, während der Logarithmus der Photolysegeschwindigkeit mit steigendem pH-Wert linear ansteigt. Der photochemische Zerfall wird mit den Ergebnissen des thermischen Zerfalls verglichen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140108
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    Zur Arylierung des Phosphorylsauerstoffs. II. Tetraphenoxyphosphonium-hexachloroantimonat (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 125-128 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Triphenylphosphat läßt sich mit Benzoldiazonium-hexachloroantimonat zur Titelverbindung arylieren. Die gleiche Verbindung ist auch aus den Produkten der Reaktion von PCl5 mit 3 bzw. 4 Mol Phenol zugänglich. Diskrepanzen in den Angaben über die Natur dieser Reaktionsprodukte werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140116
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    Zur Arylierung des Phosphorylsauerstoffs, III. Protonierung von Phosphorylverbindungen durch das Benzoldiazonium-KationHerrn Prof. Dr. Dr. h. c. Alfred Rieche mit herzlichen Wünschen zum 70. Geburtstag gewidmet (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 129-138 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In auffallendem Gegensatz zur Alkylierung wird die Arylierung des Phosphorylsauerstoffs mit zunehmender Nucleophilie desselben signifikant erschwert. Als Konkurrenzreaktion zur Arylierung kommt eine Protonierung des Phosphorylsauerstoffs zum Zuge. Bei der Umsetzung von Triphenylphosphinoxid oder Phosphorsäure-tris-(dimethylamid) führt dies zur Bildung definierter kristalliner Salze, die als H-Brückenassoziat mit einem zweiten Molekül Phosphorylverbindung vorliegen; Feuchtigkeit und überschüssige Phosphorylverbindung überführen das Protonierungsprodukt des Triphenylphosphinoxids reversibel in ein 3: 1 - Assoziat des Hydronium-hexachloroantimonats.Die Deprotonierung des Benzoldiazonium-Kations durch die Base Phosphorylsauerstoff verläuft über eine Arin-Zwischenstufe, die mit Tetracyclon abgefangen werden kann.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/prac.19723140117
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  • 63
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    Korrelationsbeziehungen bei paramagnetischen Verschiebungen mittels Tris-(dipivalomethanato)-europium(III) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 385-389 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die durch Eu (DPM)3 verursachten Signalverschiebungen lassen sich bei den Verbindungen 1-6 durch eine gute lineare Abhängigkeit von 1/R3 darstellen. Dabei gibt R den Abstand des betrachteten Protons vom Zentrum des Sauerstoffatoms der untersuchten Verbindung an. Die erhaltene Abhängigkeit gestattet Aussagen über Molekülkonformationen.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140302
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  • 64
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    Derivate der Zucker-mercaptale. XLV. Synthese und Oxydation von Di-O-benzoyl-dihydroxyaceton-dialkylmercaptalen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 437-440 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus Di-O-benzoyl-dihydroxyaceton 1 werden durch Umsetzungen mit Mercaptanen bei Gegenwart von Zinkchlorid Di-O-benzoyl-dihydroxyaceton-dialkylmercaptale 2 dargestellt, die sich mit Wasserstoffperoxid bei Gegenwart von Ammoniummolybdat zu 2,2-Bis-alkylsulfoxido- (3), mit Wasserstoffperoxid in Essigsäure zu 2,2-Bis-alkylsulfonyl-di-O-benzoyl-dihydroxyacetonen (4) oxydieren lassen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140307
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    Hydroximsäurederivate. VII. Darstellung von 1,2,4-Oxadiazol-3-carbonsäureestern (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 455-460 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: N-Acylamino-acetonitrile reagieren mit Alkylnitrit/Chlorwasserstoff in Alkoholen zu Oxalsäure-(N-acylamidoxim)-imidoesterhydrochloriden 4, die unter Einwirkung von Wasser in 1,2,4-Oxadiazol-3-carbonsäureester 5 übergehen.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/prac.19723140310
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  • 66
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    Chemie der Flechteninhaltsstoffe, XCI. Chromonglucoside aus Flechten (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 488-498 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Roccellaria mollis (Hampe) Zahlbr., Schismatomma accedens (Nyl.) Zahlbr. und Roccella galapagoensis Follm. enthalten die Chromonglucoside Roccellin 1, Mollin 2 und Galapagin 3. Roccellin ist 7-O-Diacetylglucosyleugenitol und Galapagin 7-O-Diacetylglucosyl-8-methyleugenitol. Mollin liefert bei Acetylierung Acetylroccellin 4.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140314
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    Beiträge zum Reaktionsverhalten von 2-Aminovinylcarbonylverbindungen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 353-364 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2-Chlorvinylcarbonylverbindungen reagieren mit Sarkosinäthylester unter Substitution des Chloratoms. Im Falle der 2-Chlorvinylaldehyde cyclisieren die Substitutionsprodukte sofort zu 1-Methylpyrrol-2-carbonsäureestern. Im Falle der Chlorvinylketone dagegen können die 2-[N-(Äthoxycarbonylmethyl)-N-methyl-amino]-vinylketone isoliert werden. Sie sind auch durch Umsetzung von Hydroxymethylenketonen mit Sarkosinäthylester zugänglich. Die substituierte Aminogruppe wird relativ leicht wieder abgespalten, in einigen Fällen gelingt jedoch ebenfalls eine Cyclisierung zu 1-Methylpyrrolderivaten.
    Additional Material: 10 Tab.
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    URL: http://dx.doi.org/10.1002/prac.19723140217
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    2-Amino-indene und deren Heterologe. II. Sterische Hinderung der Enolform bei heterologen Alkoxycarbonyl-indanon-(2)-DerivatenAuszugsweise vorgetragen am 10.3.1972 vor dem Kolloquium der Sektion Chemie, Universität Rostock. (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 334-352 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In Fortsetzung einer früheren Arbeit [1] wurden Thiophen-3,4-diessigsäureester mit sowohl freien als auch dialkylierten α,α′-Stellungen synthetisiert. Diese Ester wurden der DIECKMANN-Cyclisierung zu den Ketoestern 26, 27 und 28 unterworfen. Das Ausbleiben der Cyclisierung mit der 2,5-Di-tert.-butyl-Verbindung 18 wird mit sterischer Hinderung bei der Ausbildung des Ketoesterenolat-Anions 18c erklärt. Die Ketoester werden durch NMR-Spektroskopie charakterisiert und mit dem ebenfalls dargestellten Benzologen 25 verglichen. Für die Lage des Keto-Enol-Gleichgewichtes wird eine deutliche Abhängigkeit von sowohl der Größe des Alkyl-Restes in „peri“-Stellung als auch vom Alkoxy-Rest gefunden. Aus dem unsubstituierten Ketoester 27 wurde das c-annellierte Thiophenanaloge 29 zum Indanon-(2) erhalten.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/prac.19723140216
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    Die Reaktion tertiärer Amine mit Bromcyan und Wasser in Gegenwart von anorganischen Basen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 382-384 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140222
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    Kationische Farbstoffe und Vorstufen. XVI. Styrylcyanine der 1,3-Oxathiolium-Reihe (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 419-427 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In einer Einstufenreaktion werden 1,3-Oxathiolium-styrylcyanine 7 bzw. 8 aus aromatischen Aldehyden, N,N-disubstituierten Alkylthioamiden und Phenacylhalogeniden bzw. p-Chinonen hergestellt. Ein möglicher Cyanin-Bildungsmechanismus wird diskutiert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140305
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    Über das Säure-Base-Verhalten von Benzimidazolonen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 621-626 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Verschiedene Benzimidazolone wurden auf ihr Säure-Base-Verhalten in Dioxan-Wasser-Gemischen untersucht und die Aciditätskonstanten wurden bestimmt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140327
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    Neue Naphthyl-formamidine (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 639-645 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140330
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    Notiz zur Darstellung von 3-Phenyl-4,5-dialkylthiazol-2-selenonen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 646-648 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140331
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    Untersuchungen zur Reaktion von 2-Nitrocyclohexanon mit AminenHerrn Prof. Dr. Drs. h. c. Alfred Rieche in Dankbarkeit zum 70. Geburtstag gewidmet (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 891-895 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Umsetzung von 2-Nitrocyclohexanon 1 mit Aminen, Ammoniak oder Hydrazin werden unter Ringöffnung ε-Nitrocapronsäureamide 2a-d bzw. unter Wasserabspaltung ohne Ringöffnung substituierte Nitroenamine 3d-e gebildet. Das unsubstituierte 1-Amino-2-nitrocyclohexen-(1) 6 konnte ebenfalls dargestellt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140525
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    1-(2-Quinolylazo)-2-phenanthrol (QAP) as a spectrophotometric reagent and as an indicator for the determination of cobalt(II) (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 965-968 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140537
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    Extraction and Spectrophotometric Study of Copper(II) with 4-Isonitroso-1-phenyl-3-methyl-pyrazolone-5 (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 181-183 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140122
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    Masthead (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972) 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140201
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    The STOBBE condensation. X. The cyclisation of (E)-3-methoxycarbonyl-4-(5′-methyl-2′-furyl)-but-3-enoic acidi.e. COOCH3 group is in trans-position to furan ring. The nomenclature of cis/trans isomers used herein follows the IUPAC 1968 Tentative Rules, Section E, Fundamental Stereochemistry, J. org. Chemistry 35, 2849 (1970). See also: J. E. BLACKWOOD, C. L. GLADYS, K. L. LOENING, A. E. PETRARCA and J. E. RUSH, J. Amer. chem. Soc. 90, 510 (1968); Introduction to Subject Index of Chem. Abst. 66 (1963)., and (E)-3-methoxycarbonyl-4-(2′-furyl)-pent-3-enoic acid, to Benzofuran Derivatives (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 213-219 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The condensation of 5-methyl-furan-2-aldehyde and 2-furyl-methyl ketone with dimethyl succinate using either potassium t-butoxide or sodium hydride as condensing agents, gives predominantly (E)-3-methoxycarbonyl-4-(5′-methyl-2′-furyl)-but-3-enoic acid 1a and (E)-3-methoxy-carbonyl-4-(2′furyl)-pent-3-enoic acid 5 respectively. Their configurations are inferred by cyclisation with sodium acetate in acetic anhydride to the corresponding benzofuran derivatives 2,6. Alcoholysis of (E)-3-carboxy-4-(5′-methyl-2′-furyl)-but-3-enoic anhydride 3 gives the half-ester 1c which is isomeric with the half-ester 1a. A competing side reaction also gives the self-condensation product of the succinic ester 4.
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    URL: http://dx.doi.org/10.1002/prac.19723140203
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    Some reactions with 3-Methyl-1H-naphtho[2,1-b]pyran-1-one (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 271-280 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 3-Methyl-1H-naphtho[2,1-b]pyran-1-one 1 has been shown to react with various aldehydes to give the styryl derivatives 2. Reaction of 1 with P2S5 gave the thio-derivative 3 which reacted with aldehydes giving the thiostyryl-derivatives 4. Hydroxylamine reacted with 1 giving the isoxazole derivative 5. Hydrazine reacted with 2 giving the pyrazole derivative 6. Compounds 2 have been shown to undergo DIELS-ALDER reaction to give the adducts 7, 8 and 9. When 1 was allowed to react with different dicarboxylic acid anhydrides, the phthalide derivatives 10 were obtained, which on reaction with phenol, gave the dihydroxyphthalophenones 11.
    Additional Material: 7 Tab.
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    Zur basenkatalysierten Reaktion von methylenaktiven Nitrilen mit Schwefel (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 303-314 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Reaktion von Schwefel mit Cyanessigsäurederivaten führt in Gegenwart von Basen bei Raumtemperatur zu Thiophen- und Pyrrolderivaten: Aus Malonitril erhält man 2,5-Diamino-3,4-dicyano- und 2,4-Diamino-3,5-dicyanothiophen, Cyanessigester liefert je nach Reaktionsbedingungen Bis-[2-amino-3,4-dicarbäthoxy-pyrrolidyl-(5)]-disulfid,2-Amino-5-mercapto-3,4-dicarbäthoxy-pyrrol und 2,4-Diamino-3,5-dicarbäthoxy-thiophen, mit Cyanacetamid entsteht das 2-Amino-5-mercapto-3,4-dicarbamoyl-pyrrol. Die Reaktionsverläufe, die mit einer Dehydrodimerisierung beginnen, werden erörtert und einige Folgereaktionen der erhaltenen Verbindungen beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140213
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    Masthead (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972) 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140301
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    Spektroskopisches Verhalten von organischen Schwefelverbindungen. VIV. Mitt.: K. DOERFFEL u. J. BRUNN, J. prakt. Chem. 312, 701 (1970).. Rotationsisomerie um die CS-Bindung bei Benzylalkylsulfiden (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 401-418 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In den Benzylalkylsulfiden wird die Lage der CS-Valenzschwingungen in den verschiedenen Konformationen durch die unterschiedliche Stärke der Nebenvalenzkräfte bestimmt.Die kleinen Wellenzahldifferenzen der CS-Valenzschwingungen von ≤20 cm-1 haben einmal ihre Ursache in der geringfügigen Veränderung der Nebenvalenzkräfte in den unterschiedlichen Formen, zum anderen in der schwachen Kopplung der CS-Valenzschwingungen mit anderen Schwingungen infolge der großen Masse des S-Atoms.Es liegen in ihrer Polarität wenig differenzierte Raumformen vor. Ihre Zahl und Stabilität wird im wesentlichen durch sterische Effekte bedingt.Als energieärmste Form muß man für die Benzylakylsulfide die Cs-Form, d. h. die ebene Zick-Zack-Struktur annehmen. Aus Modellbetrachtungen und aus der Intensitätsverteilung der CS-Valenzschwingungen ergibt sich weiterhin, daß in geradkettigen Verbindungen die Atomanordnung „auf Lücke“ erfolgt, während in i-PrS- und s-BuS-Verbindungen auch ekliptische Formen existieren können.
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    Über Sterische Hinderungen bei der thermischen Umlagerung von Verbindungen mit cis-Propenyl-bicyclo[2,2,1]hepten- und cis-Propenyl-bicyclo[2,2,2]octen-Struktur (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 483-487 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die endo-Konfiguration ist für die COPE-Umlagerung von 2-α-Alkenyl-bicyclo[2,2,1]-heptenen-(5) und 2-α-Alkenyl-bicyclo[2,2,2]octenen-(5) eine notwendige, aber keine hinreichende Voraussetzung. cis-Propenylgruppierungen in der Seitenkette der endo-Bicycloalkene verhindern die COPE-Umlagerung vollständig; an Stelle der COPE-Umlagerung wurde Retrodien-Spaltung beobachtet.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140313
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  • 84
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    Molekülspektren und Elektronenstruktur von Monoamino-benzochinonen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 525-531 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Elektronenstruktur von Monoamino-benzochinonen ist auf Grund von Kopplungseffekten zwischen je einem Polyen- und einem Polymethin-Strukturelement interpretierbar. Die Richtigkeit der Kopplungskonzeption wird durch UV-, IR- und NMR-spektroskopische Messungen und durch das reaktive Verhalten der Aminochinone bestätigt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140318
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  • 85
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    Über Mehrparameterkorrelationen der kationischen Polymerisation von Vinylmonomeren (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 557-569 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es werden eine Reihe p-substituierter Styrole kationisch mit SnCl4 in verschiedenen Lösungsmitteln polymerisiert. Die dilatometrisch ermittelten Bruttogeschwindigkeiten sowie die Molekulargewichte der Polymeren können als Zielgrößen einer Reaktion mit den Einflußgrößen auf die Elementarprozesse korreliert werden. Substituentenkonstanten, Lösungsmittelparameter und spektroskopische Daten liefern lineare Abhängigkeiten von den genannten Zielgrößen.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140321
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  • 86
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    Steroide aus Hyodesoxycholsäure: 6-Methyl-Steroide (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 592-602 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Umsetzung von 3α-Hydroxy-6-oxo-5β-cholansäuremethylester 1 mit Methylmagnesiumjodid wurden 6α, 24, 24-Trimethyl-5β-cholantriol-(3α, 6β, 24) 2a und 6β, 24, 24-Trimethyl-5β-cholantriol-(3α, 6α, 24) 3a im Verhältnis 4:1 erhalten, während bei der entsprechenden Grignardierung des 3α-Hydroxy-6-oxo-5α-cholansäuremethylesters 7 nur 6α, 24, 24-Trimethyl-5α-cholantriol-(3α, 6β, 24) 8a isoliert wurde. Die Eigenschaften weiterer 24, 24-Dimethylcarbinole werden angegeben. Für die Darstellung von 6α-Methyl-progesteron aus Hyodesoxycholsäure wurde 20, 20-Äthylendioxy-3β-hydroxy-5α-pregnanon-(6) 13 durch Grignardierung und Dehydratisierung in Derivate des 6-Methyl-pregnenolons 15 überführt.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140324
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  • 87
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    Pyridyl-formamidin-Derivate (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 627-635 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140328
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  • 88
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    Azomethine mit Stickstofflost-Gruppen. XII. Über die Reaktion von Estern der Cyanessigsäure mit p-Nitroso-N.N-bis-(β-chloräthyl)-anilin (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 649-654 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140332
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  • 89
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    Synthesis of 2-(1-Pentyl-4-one)-3-methyl-indole and Higher Homologues (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 669-672 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140336
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  • 90
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    Synthesis of some substituted salicylanilides of expected biological activity (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 727-734 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Substituted salicylanilides are prepared by condensation of phenyl salicylates with amines. Their phenylazo and amino derivatives are also obtained and their properties discussed.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140505
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  • 91
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    Hydrazinverbindungen als Heterobestandteile in Peptiden. XV. Synthese von Eledoisin-Octapeptiden mit den Carbazylresten Azaglycin und α-Azaasparagin statt Glycin und Asparagin (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 759-768 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mit Hilfe aktivierter Ester von Azaglycin bzw. α-Azaasparaginpeptiden werden 5-Azasn-, 9-Azgly- und 5-Azasn-7-NHPhe-Eledoisin-Octapeptid 4-11Abkürzungen nach IUPAC-Information Bulletin Nr. 25, 32 (1966), vgl. Hoppe-Seyler's Z. physiol. Chem. 348, 256 (1967). Azasn = = α-Azaasparaginyl, Azgly = —NH—NH—CO— = Azaglycyl, NHPhe = α-Hydrazino-β-phenylpropionsäure; ONp = p-Nitrophenylester, OTcp = 2,4,5-Trichlorphenylester, TFA = Trifluoressigsäure. synthetisiert, ihre biologische Wirksamkeit geprüft und Betrachtungen zu ihrer Konformation angestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140508
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  • 92
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    Hydrazinverbindungen als Heterobestandteile in Peptiden. XVIXV. Mitt.: J. prakt. Chem. 314, 759 (1972), vorstehend.. Synthese von 9-Hydrazinoessigsäure-, 9-Azaglycin- und 5-α-Azaasparagin-OxytocinDie Ergebnisse wurden im Rahmen von Akademie-Abkommen zwischen der Deutschen Akademie der Wissenschaften zu Berlin und der Tschechoslovakischen Akademie der Wissenschaften zu Prag am Institut für Pharmakologie der DAW und bei Studienaufenthalten von H. N. in der Abteilung Peptidsynthese des Institutes für Organische Chemie und Biochemie der CSAV, Prag, unter der Anleitung von Prof. Dr. J. RUDINGER erarbeitet. (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 769-779 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Zur Untersuchung des Einflusses von Modifikationen der Polyamidkette auf die Konformation und die biologische Aktivität des Oxytocins wurden 9-NHGly-OT-, 9-Azgly-OT und 5-Azasn-OTAbkürzungen nach IUPAC-Information Bulletin Nr. 25, 32 (1966), vgl. a. Hoppe-Seyler's Z. physiol. Chem. 348, 256 (1967).NHGly.- = NH—NH—CH2—CO— = Hydrazinoacetyl- bzw. Hydrazinoessigsäure; Azgly- = NH—NH—CO— = Azaglycyl-; Azasn- = NH—N(CH2—CONH2)—CO— = α-Azaasparaginyl-; —OQCl = 5-Chlor-8-hydroxychinolinester; —N(Tos)Gly— = Nα-p-Toluolsulfonyl-hydrazinoacetyl- = NH—N(Tos)-CH2—CO—; APM = Aminopeptidase M; LAP = Leucinaminopeptidase; TFA = Trifluoressigsäure; OT = Oxytocin. synthetisiert. Zur Synthese des C-terminalen Hexapeptides wurden aktivierte Tripeptidester eingesetzt. Die 3 + 6-Azidsynthese erwies sich auch hier einer 6 + 3-Synthese überlegen.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140509
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  • 93
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    Reactions of Arylhydrazones of Some α-Cyanoketones with GRIGNARD Reagents (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 815-821 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The arylhydrazones of ethyl α-oxo-cyanoacetate 1a-e and the α-arylhydrazones of β-phenyl-α,β-diketopropionitrile 2a-e, react with GRIGNARD reagents at room temperature to yield the cyanocarbinols 3a-h. On the other hand, 1 and 2 react with phenylmagnesium bromide in refluxing ether-benzene mixture, to yield the imino derivatives 4a-d. 3a-e are dehydrated by hot acetic acid to yield compounds 5a-d. Similar treatment of 41-d affords the α-arylazo-β-phenylchalcones 6a-d which react with hydroxylamine to yield isoxazoline derivatives 7a-d.Treatment of 1b, d with ethereal diazomethane results in the formation of the N-methylarylhydrazones 8a, b.The arylhydrazono-malodinitriles 9 react with GRIGNARD reagents to yield the imino derivatives 10.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140515
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  • 94
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    Synthese von optisch aktiven und racemischen 3-Alkyl-tetrahydrofuranen (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 840-850 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird eine allgemeine Herstellungsmethode von 2-Alkyl-1,4-butandiolen 3 und deren Umwandlung zu den entsprechenden 3-Alkyl-tetrahydrofuranen 6 beschrieben: Ausgangsprodukte sind die 2-Alkyl-allylalkohole 1, deren Hydroformylierung in Gegenwart von Rhodium-Katalysatoren praktisch isomerisierungsfrei verläuft. Die Darstellung von (+) (3S, 1′S)- und (-) (3R, 1′S)-3-(1′-Methylpropyl)-tetrahydrofuran 6 d erfolgt nach dem hier beschriebenen Verfahren; die optische Reinheit der beiden Diastereomeren 6 d wurde bestimmt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140519
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  • 95
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    Eu(DPM)3-induzierte Verschiebungen in den 1H-NMR-Spektren von vinylogen N,N-Dimethylformamiden (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 884-890 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Der Einfluß von Eu(DPM)3-Zusätzen auf die 1H-NMR-chemischen Verschiebungen der Methyl- und der Methinprotonen von vinylogen N,N-Dimethylformamiden (einfache Merocyanine) der Formel (CH3)2N(CH)nO mit n = 1,3,5 und 7 wurde untersucht. Die Meßergebnisse können quantitativ mit Hilfe der Theorie der Pseudokontaktverschiebung wiedergegeben werden. Im untersuchten Konzentrationsbereich lagert sich der Europiumkomplex nur am Sauerstoffatom der Merocyaninkette an.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140524
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  • 96
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    The STOBBE Condensation with Dimethyl Glutarate (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 915-922 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The condensation of some heterocyclic aldehydes with dimethyl glutarate in the presence of sodium hydride, gave predominantly the (E)-half esters 1a-1es. S. 916.. Some of the aldehydes also gave the α,γ-disubstituted glutaric acids 4a-4c, which were converted to the corresponding anhydrides 5a-5c.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140529
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  • 97
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    Darstellung von N-Chlor-1,2,4-triazolen. Kinetik und Mechanismus der Umlagerung von 1-Chlor-1,2,4-triazol zu 3-Chlor-1,2,4-triazol (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 923-935 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1-Chlor-1,2,4-triazol 2a wird nach mehreren Varianten erstmalig dargestellt und seine Struktur IR- und NMR-spektroskopisch gesichert. 3-Methyl- und 3-Äthyl- 1,2,4-triazol liefern bei der Chlorierung Gemische von 1-Chlor-3-alkyl- und 1-Chlor-5-alkyl-1,2,4-triazol, in denen das letzte Derivat überwiegt, während 3-Phenyl- und 3-Chlor-1,2,4-triazol ausschließlich 1,3-Derivate ergeben. 1-Chlor-1,2,4-triazol 2a lagert sich beim Erhitzen in Wasser oder tert.-Butanol in hohen Ausbeuten in 3-Chlor-1,2,4-triazol 3a um. Die Reaktion gehorcht dem Geschwindigkeitsgesetz v = k [2a]2. Es wird bewiesen, daß 1-Chlor-1,2,4-triazol 2a das entscheidende Zwischenprodukt bei der Synthese von 3-Chlor-1,2,4-triazol 3a und 1,3-Dichlor-1,2,4-triazol 4a darstellt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140530
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  • 98
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    Reduction of Some 5-Acylthiazoles by sodium borohydride (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 961-964 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140536
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  • 99
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    Korrektur: Zur Struktur der „Methan-tris-phosphorylderivate“ (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 969-974 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die von uns kürzlich beschriebenen 3-kernigen P-Verbindungen [1] haben nicht die Struktur von Methan-tris-phosphorylverbindungen 2, sondern sind Phosphorylamide von α-Arylaminomethan-bis-phosphorylverbindungen 3. Die Struktur von 3 wurde u. a. mittels 31P- bzw. 13C-NMR-Messungen sichergestellt.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140538
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  • 100
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    Acidity Constants of the Thienyl- and Phenyl-Pyridines and Stability Constants of the Corresponding Copper (II) 1:1 Complexes (1972)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 55 (1972), S. 610-613 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The acidity constants of the six thienyl- and the three phenyl-pyridines, and the stability constants of the corresponding Cu2+ 1:1 complexes were determined in aqueous solution (I = 0.1, NaCIO4; 25°). The basicity of the pyridyl group is increased by a shift of a thienyl or phenyl group in the order 2 〈 3 〈 4 and the influence of the 2′-thienyl group is greater than that of the 3′-thienyl group. The stability of the Cu2+ 1:1 complexes formed with 3- and 4-substituted pyridines is only dependent on their basicity, as is commonly observed for structurally related ligands and their complexes. Due to steric hindrance the complexes of the 2-substituted derivatives are less stable by about 1.5 log units. There is no evidence that the aromatic bonded sulfur of 2-(2′-thienyl)-pyridine participates in complex formation with Cu2+, in opposition to an earlier claim [1].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19720550233
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