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  • 1985-1989  (12)
  • 1975-1979  (16)
  • 1970-1974  (21)
  • 1955-1959  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 29 (1974), S. 67-73 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 31 (1975), S. 394-396 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 38 (1979), S. 425-427 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 56 (1988), S. 106-106 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2307
    Keywords: Immunodeficiency ; Immunologic disorders ; Immune system ; Thymus ; Lymphatic Tissue ; Congenital disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histologic, immunohistologic and electron microscopic findings in three children with primary immunodeficiencies are reported. Classical X-linked infantile agammaglobulinemia Bruton was present in case 1 (♂, aged 16 years), selective cellular immunodeficiency with thrombopenia in case 2 (♂, aged 2 1/2 years) and non-lymphopenic severe combined immunodeficiency in case 3 (♂, aged 1 3/4 years). At autopsy, all three cases exhibited unusual types of pneumonia. In case 2 a generalized cytomegalovirus infection was present. Case 3 disclosed panmyelopathia and chronic liver lesions due to severe GvH-reaction subsequent to bone marrow transplantation. A detailed morphologic study of the immune system revealed distinct alterations in the thymus, spleen, and lymph nodes and the lymphatic tissues of the gastrointestinal tract characteristic of an immunodeficiency state, either humoral (case 1), cellular (case 2) or combined (case 3).
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 159 (1972), S. 44-49 
    ISSN: 1433-8580
    Keywords: Adult, fetal haemoglobin ; Globin ; Pig ; Development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vergleichende Untersuchungen an Polypeptidketten des Hämoglobins von erwachsenen Schweinen und Embryonen bzw. Feten verschiedener Entwicklungsstadien ließen keine Unterschiede in der Struktur derα-Ketten einerseits und der Nicht-α-Ketten andererseits erkennen. Diese Aussage bezieht sich auf Analysen des Globins mit chromatographischen und elektrophoretischen Methoden sowie mit der Fingerprinttechnik. Die Ergebnisse lassen den Schluß zu, daß beim Schwein während der Fetalzeit keine Synthese vonγ-Ketten (fetales Hämoglobin) stattfindet.
    Notes: Summary Studies on polypeptide chains of haemoglobin from adult pigs compared with those from fetuses respectively embryos revealed no differences in the structure of either theα-chains or the non-α-chains. The results were obtained by chromatographic, electrophoretic and fingerprint techniques. It is concluded that no γ-chains (fetal haemoglobin) are synthesized in red cells of pigs during developmental stages.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 158 (1972), S. 219-228 
    ISSN: 1433-8580
    Keywords: Fetal hemoglobin ; Pig ; Development ; Fetales Hämoglobin ; Schwein ; Ontogenese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter der Fragestellung, ob beim Schwein in Analogie zu anderen Species während der Ontogenese ein fetales Hämoglobin synthetisiert wird, wurden Eigenschaften des Blutfarbstoffs von Embryonen und Feten mit einer Kopf-Steiß-Länge von 20 bis 230 mm mit denen erwachsener Schweine verglichen. Weder mit elektrophoretischen und chromatographischen Methoden noch mit einer Reihe von Denaturierungstesten (Alkali, Säure, Hitze) und Spektralanalysen im sichtbaren und ultravioletten Bereich konnte bei Feten ein fetales Hämoglobin nachgewiesen werden. Ob sich der Prozeß der Synthese eines fetalen Blutfarbstoffs und sein Ersatz durch adultes Hämoglobin bereits in der Embryonalperiode abspielt, kann aus den bisher vorliegenden Daten nicht gefolgert werden.
    Notes: Summary The existence of a fetal hemoglobin synthesized in pigs during developmental stages is contested (Novyet al., 1968; Kleihauer, 1970; Glauser and Glauser, 1971). Comparative studies have been performed in hemolysates of adult pigs and fetuses resp. embryos with a crown-rump length ranging between 20 and 230 mm applying the following techniques: electrophoresis on starck block and cellulose acetate folie, chromatography on DEAE-sephadex, denaturation by alkali, acid and heat, and spectral analysis in the visible and ultraviolet range. The results give good evidence that no fetal hemoglobin is present in pigs during fetal life. However, whether a fetal hemoglobin is synthesized and fully replaced by an adult type hemoglobin already during embryonic stages remains to be investigated.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 161 (1973), S. 243-250 
    ISSN: 1433-8580
    Keywords: Free alpha chains ; Adult/cord blood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A minor haemoglobin component consisting of freeα-chains is regulary present in haemolysates of human cord and adult blood. The isolation is achieved by chromatography on DEAE-Sephadex A50 in Tris-HCL-KCN buffer at pH 8.63. In normal adults the amount is in the range between 0.034 and 0.090 (mean 0.061) percent, in fullterm newborns between 0.042 and 0.101 (mean 0.075) percent of the total haemoglobin mass. Freeα-chains are missing in premature infants. In inherited deficiencies ofβ-chain production the amount of freeα-chains in highly increased. Theα-chain component isolated by preparative column chromatography had the same electrophoretic mobility as native PCMBα-chains. In hybridization experiments the component recombined with canine haemoglobin forming the hybridα 2 A β 2 Can. Mixed with haemolysates containing haemoglobin H the freeα-chains combined with the excess ofβ-chains, indicating that they are structurally normal. The quantitative determination of freeα-chains is thought to be helpful for the detection ofβ-thalassaemia in the neonatal period and for the recognition ofα-thalassaemia states without excess ofβ-chains.
    Type of Medium: Electronic Resource
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