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  • 2005-2009
  • 1990-1994  (249)
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  • 101
    Digitale Medien
    Digitale Medien
    Constant-Rate Intravenous Infusion Methods for Estimating Steady-State Volumes of Distribution and Mean Residence Times in the Body for Drugs Undergoing Reversible Metabolism (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 628-632 
    Details
    ISSN: 1573-904X
    Schlagwort(e): intravenous infusion ; volume of distribution ; mean residence time ; reversible metabolism ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Equations for the steady-state volumes of distribution (V ss) and the mean residence times in the body (MRT) are derived for a drug and its metabolite subject to reversible metabolism and separately infused intravenously at a constant rate to steady state of both compounds. The V ss and MRT parameters are functions of the integrals of plasma concentrations, plasma concentrations at steady state, and times to reach steady state of both drug and metabolite. In addition, the MRT values are functions of the infusion rates. These equations were validated by computer simulations and comparison with IV bolus dose parameters. These relationships extend the ability to assess the pharmacokinetics of linear reversible metabolic systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015874329265
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  • 102
    Digitale Medien
    Digitale Medien
    Influence of Absorption Rate, Dosing Frequency, and Intrinsic Pharmacokinetic Profile on Steady-State Drug Concentrations (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 677-680 
    Details
    ISSN: 1573-904X
    Schlagwort(e): pharmacokinetics ; absorption rate ; diurnal variation ; dosing frequency ; steady-state concentrations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015894901040
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  • 103
    Digitale Medien
    Digitale Medien
    A Sensitive and Specific Liquid-Chromatographic Assay for Determination of Ganciclovir in Plasma and Urine and Its Application to Pharmacokinetic Studies in the Rabbit (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1113-1118 
    Details
    ISSN: 1573-904X
    Schlagwort(e): ganciclovir ; analysis ; pharmacokinetics ; rabbit model ; renal secretion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A liquid-chromatographic assay for the analysis of ganciclovir in plasma and urine is described. This assay involves the use of acyclovir, an antiviral drug structurally related to ganciclovir, as the internal standard. A two-step sample preparation method is used. After protein is precipitated with acetonitrile and the addition of diethyl ether, ganciclovir and the internal standard are back extracted into a small volume of aqueous ammonium phosphate, taking advantage of their relatively high water solubility. This isocratic method is specific and sufficiently sensitive to allow quantification of ganciclovir throughout the entire range of concentrations observed during therapeutic use of this antiviral drug. There was no interference from various over-the-counter and prescription drugs often prescribed to patients most likely to receive ganciclovir therapy. This assay was used to analyze plasma and urine samples obtained after intravenous administration of ganciclovir to rabbits. Biexponential decay of ganciclovir plasma concentration–time and urinary excretion rate–time profiles was observed, with a mean distribution half-life of 15.8 min and an elimination half-life of 96 min. The mean renal clearance, 9.0 ml/min per kg, exceeds the glomerular filtration rate in the rabbit, indicating that ganciclovir is actively secreted in the renal tubule. Similar results were obtained by determining the renal clearance at steady state during constant-rate intravenous infusion of ganciclovir.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015920023272
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  • 104
    Digitale Medien
    Digitale Medien
    Evaluation of the Pharmacokinetic Interaction Between Diazepam and ACC-9653 (a Phenytoin Prodrug) in Healthy Male Volunteers (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1172-1176 
    Details
    ISSN: 1573-904X
    Schlagwort(e): diazepam ; phenytoin ; ACC-9653 ; prodrug ; protein binding ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The protein binding and pharmacokinetics of diazepam, ACC-9653 (a phenytoin prodrug), and phenytoin were evaluated in nine healthy male volunteers following administration of diazepam and ACC-9653, alone or concomitantly, in a randomized crossover design. No significant differences were observed in the fraction unbound or pharmacokinetic parameters of ACC-9653, phenytoin, or diazepam when ACC-9653 was administered alone compared to concomitant administration with diazepam. The phenytoin fraction unbound increased significantly with increased concentrations of ACC-9653, indicating displacement of phenytoin from its binding sites by ACC-9653. ACC-9653 also demonstrated concentration dependent binding. The lack of a significant pharmacokinetic drug interaction between ACC-9653 and diazepam suggests that these drugs may be safely administered together, although this conclusion should be confirmed in the intended patient population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015940527815
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  • 105
    Digitale Medien
    Digitale Medien
    An Experimental Model for Measuring Middle Ear Antimicrobial Drug Penetration in Otitis Media (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1242-1247 
    Details
    ISSN: 1573-904X
    Schlagwort(e): otitis media ; pharmacokinetics ; amoxicillin ; trimethoprim ; sulfamethoxazole
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Bacteria are an important cause of acute otitis media and successful treatment depends on achieving inhibitory or bacteriacidal antimicrobial drug concentrations in the middle ear. To evaluate further otitis media treatment success and failure, we developed a chinchilla model to study antimicrobial drug penetration through the middle ear mucosa. Using quantitative histomorphometry, we measured the middle ear space in 10 chinchillas and found a mean ±SD volume of 2.09 ± 0.08 ml and a mean SD surface area of 14.41 ± 1.48 cm2. To measure the apparent rate constant (K e) of antibiotic elimination from the middle ear, through the middle ear mucosa, an antibiotic solution was inoculated into the middle ear cavity, and samples were aspirated between 1 and 8 hr later. In normal ears, the mean K e ±SD for amoxicillin was 0.118 ± 0.013 hr−1, that for a trimethoprim 0.461 ± 0.090 hr−1, and that for sulfamethoxazole 0.265 ± 0.062 hr−1. In ears inoculated with type 7F Streptococcus pneumoniae to induce acute otitis media, the K e ±SD increased for all three drugs (P 〈 0.05): amoxicillin to 0.286 ± 0.089 hr−1, trimethoprim to 0.662 ± 0.118 hr−1, and sulfamethoxazole to 0.411 ± 0.056 hr−1. These values demonstrate that amoxicillin had the lowest apparent penetration rate constant of the three antibiotics but the greatest increase from normal to infected mucosa (142%). Trimethoprim had the highest apparent penetration rate constant of the three antibiotics but the smallest increase from normal to infected mucosa (44%), while the sulfamethoxazone apparent penetration rate constant increased from normal to infected mucosa by 55%. The K e for amoxicillin was the same for inoculation volumes of 0.8 and 1.6 ml (P = 0.557) and the same for sampling intervals of 4 and 8 hr (P = 0.054). All three antimicrobial drug concentration–time curves were log-linear, as predicted by Fick's first law of diffusion. In conclusion, this model overcomes the technical limitations of previous models and permits investigation of the many factors that can influence antibiotic penetration into the middle ear and reduce otitis media treatment efficacy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015977603224
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  • 106
    Digitale Medien
    Digitale Medien
    Hydralazine Pharmacokinetics and Interaction with Food: An Evaluation of the Dog as an Animal Model (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 274-279 
    Details
    ISSN: 1573-904X
    Schlagwort(e): hydralazine ; food–drug interaction ; Michaelis–Menten kinetics ; bioavailability ; pharmacokinetics ; dog ; animal model
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The intravenous and oral dose-dependent pharmacokinetics of hydralazine and the effect of concurrent administration of food with hydralazine in dogs were evaluated for comparison with published human data. Four dogs were given intravenous and oral doses of hydralazine at 0.25, 1.0, 2.5, and 4.0 mg/kg. In addition, the oral 2.5 mg/kg dose was given with a meal. Blood samples were collected at appropriate intervals and analyzed for hydralazine. Pharmacokinetic analysis showed that AUCoral/ dose (5552 to 13218 mg-min/ml) and F (0.36 to 0.77) increased significantly with dose, indicating saturation of first-pass metabolism, as is seen in humans. Total-body clearance (70 ml/min/kg) and steady-state volume of distribution (9 L/kg) were similar to human values. The bioavailability of hydralazine in the dog was decreased by 63% when the dose was given with a meal, which is comparable to some human data. It was concluded that the dog may be a useful model in which to study mechanisms of the hydralazine-food interaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015830330231
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  • 107
    Digitale Medien
    Digitale Medien
    Dose-Dependent Pharmacokinetics of Carbamazepine in Rats: Determination of the Formation Clearance of Carbamazepine-10,11-epoxide (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 513-517 
    Details
    ISSN: 1573-904X
    Schlagwort(e): carbamazepine ; carbamazepine-10,11-epoxide ; pharmacokinetics ; dose dependency ; metabolite ; blood
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The dose dependency of carbamazepine pharmacokinetics was characterized in rats, a common test animal for antiepileptic drug efficacy. With a randomized Latin square schedule, 5, 10, and 20 mg/kg doses of carbamazepine were injected intravenously into six Sprague-Dawley rats followed by the administration of a 5 or 10 mg/kg i.v. dose of CBZ-E to each rat. Following administration, the concentrations of CBZ and Carbamazepine-10,11-epoxide (CBZ-E) in whole blood were determined by a reverse-phase HPLC assay. Plasma protein binding of both carbamazepine and CBZ-E was linear over the concentration range observed in this study. Carbamazepine concentration–time plots were log-linear, but the slopes were not parallel. Carbamazepine total-body clearances were 15.1 ± 3.26, 13.4 ± 5.66, and 10.0 ± 3.11 ml/min/kg at the 5, 10, and 20 mg/kg doses, respectively (significance of difference between the 5 and the 20 mg/kg dose = 0.06 〈 P 〈 0.05; Kruskal–Wallis test, Dunn's procedure). However, the formation clearance to CBZ-E did not change, suggesting that metabolism via other pathways was decreased at higher carbamazepine doses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015872901523
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  • 108
    Digitale Medien
    Digitale Medien
    Influence of Food on the Bioavailability of Ro 15-0778 in Humans (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 777-779 
    Details
    ISSN: 1573-904X
    Schlagwort(e): arotinoid ; bioavailability ; food effect ; pharmacokinetics ; humans
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015836110126
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  • 109
    Digitale Medien
    Digitale Medien
    Differential Effects of Anesthetic Regimens on Gentamicin Pharmacokinetics in the Rat: A Comparison with Chronically Catheterized Conscious Animals (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 41-45 
    Details
    ISSN: 1573-904X
    Schlagwort(e): gentamicin ; carboxyinulin ; pharmacokinetics ; anesthesia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The intravenous disposition of gentamicin was compared in the conscious chronically catheterized rat with that in rats anesthetized using five injectable laboratory anesthetics. Gentamicin plasma clearance in the conscious rat was significantly higher than in animals anesthetized with urethane, fentanyl/ fluanisone/midazolam, pentobarbitone, or ketamine/midazolam but similar to that in rats anesthetized with alphaxolone/alphadolone. Urethane anaesthesia resulted in a significantly lower gentamicin clearance than in all other groups. Gentamicin clearance in rats anesthetized with alphaxolone/alphadolone was significantly higher than in rats anesthetized with either fentanyl/fluanisone/midazolam or urethane. No significant differences in the volume of distribution of gentamicin were observed between any of the groups studied, either anesthetized or conscious. Carboxyinulin blood clearance in the conscious group was significantly higher than that with urethane, fentanyl/fluanisone/midazolam, pentobarbitone, or ketamine/midazolam but not significantly different from alphaxolone/ alphadolone-anesthetized animals. The differences in carboxyinulin clearance were noted to be proportional to the differences in gentamicin clearance (r 2 = 0.98). These results demonstrate that the choice of anesthetic used in laboratory pharmacokinetic studies is important. Gentamicin clearance was higher in conscious than anesthetized rats, and it may be prudent to use chronically catheterized animals in pharmacokinetic studies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015879324354
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  • 110
    Digitale Medien
    Digitale Medien
    The Effects of Urine pH Modification on the Pharmacokinetics and Pharmacodynamics of Phenylpropanolamine (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 96-102 
    Details
    ISSN: 1573-904X
    Schlagwort(e): phenylpropanolamine ; urinary pH modification ; urine alkalinization ; renal clearance ; pharmacokinetics ; pharmacodynamics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract To determine whether uninary alkalinization had an effect on the plasma pharmacokinetics and pharmacodynamics of phenylpropanolamine, a double-blind crossover study was conducted in four healthy, normotensive male volunteers. The subjects received 25 mg immediate-release phenylpropanolamine and either placebo or sodium bicarbonate in a balanced randomized order. The bicarbonate treatment consisted of 6 g sodium bicarbonate 30 min prior to the phenylpropanolamine and then 3 g sodium bicarbonate every 4 hr for the next 16 hr. During the control treatment, phenylpropanolamine and a placebo for bicarbonate (lactose) were given on the same schedule. Blood and urine samples were collected over 24 hr and analyzed by HPLC. A supine blood pressure and pulse were obtained before each blood sample. The bicarbonate treatment significantly increased the urine pH throughout the study period and decreased phenylpropanolamine renal clearance by 33.5%. The apparent total-body clearance was also decreased by 31.5% and resulted in higher postabsorptive plasma phenylpropanolamine concentrations in each subject as compared to the control treatment. Both systolic and diastolic blood pressures changed significantly from baseline in both treatments. The bicarbonate treatment was accompanied by significantly higher diastolic blood pressures than in the control treatment, but there was no effect on systolic blood pressures. Generally, when the blood pressure–concentration pairs were plotted chronologically, clockwise hysteresis curves resulted. Heart rates did not change significantly from baseline values for either treatment. In this small group of normotensive healthy male volunteers, urinary alkalinization significantly depressed the renal clearance of phenylpropanolamine, producing higher postabsorptive phenylpropanolamine plasma concentrations and a small but significant increase in the diastolic blood pressure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015852012968
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  • 111
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of Methylergometrine in the Rat: Evidence for Enterohepatic Recirculation by a Linked-Rat Model (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 14-20 
    Details
    ISSN: 1573-904X
    Schlagwort(e): methylergometrine ; pharmacokinetics ; rat ; enterohepatic recirculation ; protein binding ; volume of distribution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The pharmacokinetics of methylergometrine were investigated in the rat, with emphasis on the role of biliary excretion and enterohepatic recirculation in the overall disposition of the drug. A linked-rat model, where the bile from a rat receiving a constant rate of iv infusion of methylergometrine was allowed to flow into the duodenum of another rat, was used for the estimation of the degree of enterohepatic recirculation (EHC). The excretion of unchanged methylergometrine in the bile was estimated separately. Plasma protein binding and plasma-to-whole blood partitioning were also determined. Plasma clearance in control rats was 17.4 ± 0.7 ml/min × kg for iv bolus and 15.4 ± 0.7 ml/min × kg for iv infusion. The corresponding values in the bile-cannulated rats were significantly lower, 7.7 ± 0.4 and 8.7 ± 0.1 ml/min × kg, respectively. The lower clearance in the bile-cannulated rats was caused mainly by a lower free fraction in plasma, f u (0.11 ± 0.01), in this group compared with the control group (0.19 ± 0.0.03). The unbound volume of distribution at steady state (V ssu) was only 6.5 liters/kg in the bile-cannulated rats, compared to 14.7 liters/kg in control rats, suggesting that under steady-state conditions, more than 50% of the methylergometrine is conjugated or resides in the hepatobiliary loop, either as a conjugate or unchanged. The fraction of unchanged methylergometrine excreted in the bile was less than 0.3% of the given dose, while the fraction of the dose being reabsorbed during one cycle (f reabs) was 8.4 ± 6.3%. Thus, recirculation is due mainly to excretion of conjugates subsequently hydrolzyed in the GI tract prior to absorption. In spite of this relatively low degree of EHC, the terminal half-life was reduced from 186 ± 22 min in control rats to 79 ± 5 min in rats with an interrupted EHC. The data presented emphasize the role of enterohepatic recirculation in the disposition of a drug, i.e., even if the extent of EHC is relatively low, it may markedly effect the apparent volume of distribution, hence the terminal half-life of a drug.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015871122537
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  • 112
    Digitale Medien
    Digitale Medien
    Mean Residence Times of Multicompartmental Drugs Undergoing Reversible Metabolism (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 103-107 
    Details
    ISSN: 1573-904X
    Schlagwort(e): pharmacokinetics ; moment analysis ; reversible metabolism ; mean residence times
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015804129806
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  • 113
    Digitale Medien
    Digitale Medien
    Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 237-241 
    Details
    ISSN: 1573-904X
    Schlagwort(e): bismuth ; pharmacokinetics ; biliary excretion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The pharmacokinetics and biliary excretion profile of intravenously administered bismuth ions were investigated in male Sprague Dawley rats. The data indicated that in the dose range studied, the percentage of dose excreted in urine ranged from 58 to 63%. The mean residence time for bismuth ions was 3.93, 4.07, and 5.45 hr for the 0.5, 0.75, and 1.0 mg/kg dose, respectively, while the volume of distribution at steady state was 0.75, 1.24, and 1.38 L/kg for the three doses. Blood clearance values ranged from 0.2 to 0.32 L/hr/kg. Blood bismuth ion concentrations toward the latter part of the sampling schedule indicated significant variability. The bile-to-blood concentration ratio of intravenously administered bismuth exceeded 1.0 for the three doses studied, suggesting that transport of bismuth from blood to bile may be carrier mediated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015813826597
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  • 114
    Digitale Medien
    Digitale Medien
    Single- vs Multiple-Dose Pharmacokinetics of Clozapine in Psychiatric Patients (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 347-351 
    Details
    ISSN: 1573-904X
    Schlagwort(e): clozapine ; pharmacokinetics ; single- vs multiple-dose regimen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Clozapine plasma levels were monitored in 16 patients during a series of three consecutive treatments (single dose–multiple dose–single dose). Each patient received a single 75-mg dose (3 × 25 mg) with clozapine tablets, and serial plasma samples were collected over 48 hr after the dose. At 48 hr, a multiple-dose regimen was started, consisting of an initial dose escalation period followed by dosing at a constant regimen for at least 6 days. After the last dose, serial plasma samples were again obtained over 72 hr. Drug was then withheld for at least 7 days, a final single 75-mg dose was given, and plasma sampling was repeated. A subset of the patient population (N = 7) was used to test for a food effect during the single-dose treatments. The pharmacokinetic parameters between the initial and the final single dose periods were not significantly different. Similarly, there were no differences within patients when given the dose after fasting (fed 1 hr after dose) or with a meal. In contrast, the terminal elimination rate differed between the single-dose and the multiple-dose treatments (t $$_{{\raise0.5ex\hbox{$\scriptstyle 1$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle 2$}}} $$ m3 = 7.9 hr single dose and 14.2 hr multiple dose) (P 〈 0.05) and the dose-normalized area under the plasma concentration/time curves increased 27% with multiple dosing. Since a previous study in patients (Choc et al., Pharm. Res. 4:402–405, 1987) showed dose proportionality of clozapine plasma concentrations during multiple-dose regimens, the present results cannot be described by Michaelis–Menten kinetics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015859103824
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  • 115
    Digitale Medien
    Digitale Medien
    Altered Pharmacokinetics and Dynamics of Apomorphine in the Malnourished Rat: Modeling of the Composed Relationship Between Concentration and Heart-Rate Response (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 318-324 
    Details
    ISSN: 1573-904X
    Schlagwort(e): apomorphine ; pharmacokinetics ; pharmacodynamics ; heart rate ; rat ; malnutrition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The impact of malnutrition on the pharmacokinetics and pharmacodynamics (change in heart rate) of apomorphine was studied in the rat. One group of rats received a low-protein diet (0.5%) ad libitum to produce prekwashiorkor. The control group received commercial food pellets. In the first experiment, the two groups received a 2 mg/kg iv bolus dose of apomorphine to determine any differences in the basic pharmacokinetic parameters. The pharmacodynamic characteristics in each group were studied at different steady-state plasma levels, achieved by iv infusions with continuous measurements of the heart rate. There was an almost twofold decrease in the plasma clearance in the malnourished rats compared with controls. A pronounced change in the pharmacodynamic response was also observed in the malnourished group. In the control group, apomorphine produced bradycardia at low concentrations and tachycardia at high concentrations, while only bradycardia was registered in the malnourished group, with maximum effects at steady-state plasma concentrations of 50 ng/ml and a return to baseline at higher concentrations. The effects in control and malnourished rats were fitted simultaneously to the sum of two Hill equations with a nonlinear regression program, and the fits were compared by means of an F test. The maximum pure tachycardia obtainable differed significantly in the prekwashiorkor group compared to the control group. These results suggest a selective down regulation/desensitization only of the receptors responsible for the tachycardia produced by apomorphine during malnutrition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015850802006
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  • 116
    Digitale Medien
    Digitale Medien
    Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 691-696 
    Details
    ISSN: 1573-904X
    Schlagwort(e): basic drugs ; tissue distribution ; lipophilicity ; rabbits ; distribution of nonionized drug ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The relationship between the tissue-to-plasma partition coefficients (K p) and drug lipophilicity was investigated using highly lipophilic drugs with apparent partition coefficients of 150 or above in an octanol–water system at pH 7.4. Ten clinically popular basic drugs with different dissociation coefficients (pK a) and lipophilicity were used. The K p values were determined in nondisposing organs after the i.v. administration of individual drugs in rabbits. The free fraction in plasma and the blood-to-plasma concentration ratio were determined in vitro. Then the tissue-to-plasma ratios of nonionized and unbound drug concentrations (K pfu) were calculated from K pf (ratio of unbound drug). The true octanol–water partition coefficient of the nonionized drugs (P) was used to analyze the K pf and K pfu. In all tissues, log K pfu was more highly correlated with log P than log K pf.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015803202857
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  • 117
    Digitale Medien
    Digitale Medien
    A Redox-Based System that Enhances Delivery of Estradiol to the Brain: Pharmacokinetic Evaluation in the Dog (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 879-883 
    Details
    ISSN: 1573-904X
    Schlagwort(e): estradiol ; chemical delivery system ; brain enhanced drug delivery ; blood–brain barrier ; pharmacokinetics ; redox drug delivery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The pharmacokinetics of a dihydropyridine–pyridinium salt-type chemical delivery system (CDS) for brain-targeted delivery of estradiol (E2) were examined in dogs. Parameters evaluated in vitro included stability in buffers and biological fluids and plasma protein binding. In vivo studies examined drug and metabolite concentrations in plasma, urine, and cerebrospinal fluid as well as in selected brain regions. The administered lipophilic E2-CDS disappeared very quickly from plasma and was not detected in urine. The oxidized drug form, E2-Q+, was excreted unchanged or as a conjugate in the urine for as long as 2 weeks. Plasma levels were below assay detection limits at later times. Pharmacokinetic analysis of urine E2-Q+ levels allowed estimation of a half-life of 2.2 days. Amounts of E2-Q+ excreted into the urine were proportional to the dose but averaged only 13.9% of the dose, indicating that other routes of excretion must be considered. CSF levels were below the limit of detection for both E2-CDS and E2-Q+, however, brain tissue concentrations of E2-Q+ were similar in several brain regions of individual animals examined 1 or 3 days after drug dosing.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015977319212
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  • 118
    Digitale Medien
    Digitale Medien
    Performance of Diltiazem Tablet and Multiparticulate Osmotic Formulations in the Dog (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 874-878 
    Details
    ISSN: 1573-904X
    Schlagwort(e): diltiazem ; controlled release ; deconvolution ; dog ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The in vivo performance of two extended-release (ER) osmotic formulations of diltiazem were evaluated in the beagle dog. Both ER formulations had similar bioavailabilities (F) as the diltiazem solution. Although F was somewhat variable following ER administration, this variability may be related to the drug entity since intra- and interanimal variability of orally administered diltiazem solutions was substantial. Deconvolution of the ER plasma diltiazem data with absorption data from the orally administered diltiazem solutions provided an estimate of the in vivo drug release from the ER formulations. The two ER formulations, designed with different in vitro release profiles, reflected these differences in vivo, with nearly identical respective in vivo and in vitro release profiles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015925302374
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  • 119
    Digitale Medien
    Digitale Medien
    Comparison of Single-Dose and Steady-State Nadolol Plasma Concentrations (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 953-956 
    Details
    ISSN: 1573-904X
    Schlagwort(e): nadolol ; pharmacokinetics ; high-performance liquid chromatography (HPLC) ; nonlinearity ; β-blocker
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The pharmacokinetics of nadolol have been previously reported to be linear between single and steady-state dosing. Data from a study in our laboratory suggested greater than expected β-blockade with nadolol at steady state. Because the early potency studies were single-dose studies, we hypothesized there was a nonlinearity in nadolol pharmacokinetics which produced higher than expected plasma concentrations at steady state. Six normal volunteers from the previous study (steady state) volunteered to participate in the single-dose study. Plasma concentrations were determined for 24 hr following a single dose of nadolol, 80 mg. A simple, inexpensive, and accurate method for determination of nadolol in plasma or serum by HPLC with fluorometric detection is described. The AUCo–tau at steady state was greater than the AUC0–∞ following a single dose in five of the six subjects. The mean ratio of AUCss/AUCsd was 2.54. This value would be unity in the presence of linear pharmacokinetics. We conclude that the principle of superposition is not applicable for nadolol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1015954108734
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  • 120
    Digitale Medien
    Digitale Medien
    Stereoselective disposition of ibuprofen and flurbiprofen in rats (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 134-140 
    Details
    ISSN: 0899-0042
    Schlagwort(e): pharmacokinetics ; enantiomers ; 2-arylpropionates ; chiral inversion ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: (R)-2-Arylpropionates are often inverted to the pharmacologically active S-enantiomers in vivo, although there is significant interspecies variability in inversion. In order to provide a basis for determining the biochemical consequences of this unique process using rats as a model, it was important to establish the pharmacokinetic disposition of the enantiomers of ibuprofen, a drug well inverted in man and flurbiprofen, a drug apparently poorly inverted in man. Rats were dosed i.v. with a single dose of (R)-or (S)-ibuprofen (20 mg/kg), (R,S)-ibuprofen (40 mg/kg), (R)- or (S)-flurbiprofen (10 mg/kg), or (R,S)-flurbiprofen (20 mg/kg). Each treatment group consisted of six animals. Serial blood samples were withdrawn over a period of 6 h for ibuprofen and 10 h for flurbiprofen. These drugs were assayed in plasma by a stereospecific HPLC assay. The pharmacokinetics of the ibuprofen and flurbiprofen enantiomers were evaluated using a two-compartment open model with conversion of the R- to S-enantiomers in the central compartment. There was 50 ± 4% inversion of (R)-ibuprofen, a figure similar to that observed in man and (R)-ibuprofen had a higher clearance (12.6 ± 1.3 ml/min/kg) than (S)-ibuprofen (7.7 ± 0.7 ml/min/kg; P 〈 0.01). The clearance of (R)- flurbiprofen after racemate (2.3 ± 0.1 ml/min/kg) was higher than its clearance when administered alone (1.7 ± 0.2 ml/min/kg; P 〈 0.01), indicating a pharmacokinetic interaction between the enantiomers (most probably at plasma protein binding sites). A corresponding difference was not observed for ibuprofen. There was a small amount of inversion of (R)-flurbiprofen as determined by area analysis (4.5 ± 1.6%). However, this calculation may be in some error because of the interaction between the enantiomers. These data demonstrate quantitative similarities in the inversion of ibuprofen and flurbiprofen in rats and man, a useful basis for comparing the effects of these two drugs on fatty acid metabolism.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/chir.530020303
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  • 121
    Digitale Medien
    Digitale Medien
    Interindividual variability in the enantiomeric disposition of ibuprofen following the oral administration of the racemic drug to healthy volunteers (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 249-256 
    Details
    ISSN: 0899-0042
    Schlagwort(e): ibuprofen enantiomers ; R,S-ibuprofen ; enantiomer disposition ; pharmacokinetics ; human study ; interindividual variability ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The plasma disposition of the enantiomers of ibuprofen has been investigated following the oral administration of the racemic drug (400 mg) to 24 healthy male volunteers. The plasma elimination of (R)-ibuprofen was found to be more rapid than that of the S-enantiomer [plasma half-life: (R) 2.03 h; (S) 3.05 h; 2P 〈 0.001], resulting in a progressive enrichment in the plasma content of this isomer, some 64% of the total area under the plasma concentration time curves (AUC) being due to the pharmacologically active enantiomer. The influence of dose on the pharmacokinetic characteristics of the enantiomers of ibuprofen, over the range 200-800 mg, was investigated in three subjects. Examination of dosenormalized AUC values and oral clearance indicate the dose dependence of (R)-ibuprofen disposition.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/chir.530020410
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  • 122
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and distribution of ampicillin in plasma, milk and uterine fluid of female buffaloes (1990)
    Springer
    Veterinary research communications 14 (1990), S. 47-51 
    Details
    ISSN: 1573-7446
    Schlagwort(e): ampicillin ; buffalo ; milk ; pharmacokinetics ; plasma ; uterine fluid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A pharmacokinetic study of ampicillin (6 mg/kg intravenous) revealed that the peak concentrations of 17.81±1.25, 5.64±2.24 and 1.09±0.10 μg/ml of the drug were attained at 15 min, 30 min and 2 h in plasma, milk and uterine fluid respectively. A therapeutic concentration of ≥0.1 μg/ml was maintained from 15 min–8 h, 15 min–6 h and 30 min–6 h in plasma, milk and uterine fluid. Hence, the drug may be used effectively in mammary gland and uterine infections apart from its use in other systemic infections.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00346383
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  • 123
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and dosage regimen of cephalexin in buffalo calves (Bubalus bubalis) following single intravenous and intramuscular administration (1990)
    Springer
    Veterinary research communications 14 (1990), S. 59-62 
    Details
    ISSN: 1573-7446
    Schlagwort(e): buffalo ; cephalexin ; pharmacokinetics ; treatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00346385
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  • 124
    Digitale Medien
    Digitale Medien
    A discriminatory study of a pharmacokinetic model for intramuscular gentamicin in sheep (1990)
    Springer
    Veterinary research communications 14 (1990), S. 53-58 
    Details
    ISSN: 1573-7446
    Schlagwort(e): gentamicin ; models ; pharmacokinetics ; sheep
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The resulting serum concentrations were measured in six ewes after intramuscular administration of 10 mg/kg of gentamicin. The model providing the best fit for the experimental data was determined both by linear regression analysis between the experimental and theoretical values and by means of the Minimum Akaike Information Criterion Estimation (MAICE) test. Linear regression analysis showed certain differences favouring the monocompartmental model although the advantage was not conclusive. The MAICE test, however, permitted a clear discrimination in favour of the same model. When linear regression analysis is not conclusive, the MAICE test represents a good alternative.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00346384
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  • 125
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of kemantane in rats (1990)
    Springer
    Bulletin of experimental biology and medicine 110 (1990), S. 1519-1521 
    Details
    ISSN: 1573-8221
    Schlagwort(e): kemantane ; immunostimulator ; pharmacokinetics ; active metabolite
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00841308
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  • 126
    Digitale Medien
    Digitale Medien
    Untersuchungen zur Konstruktion von Bordetella bronchiseptica-Mutantenstämmen durch Transposonmutagenese und deren Prüfung zur Eignung als potentielle Impfstämme (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 185-191 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Three wild type strains of B. bronchiseptica were mutagenized with the transposon Tn 5. Since the transponson Tn 5 encodes resistance to kanamycin, a selection for resistance to these antibiotics can be used as an indicator for Tn 5 transposition.9 mutants were identified that are not able to grow on minimal medium. Subsequent auxotrophic tests on these mutants revealed 7 valine, 1 cysteine and 1 valine and leucine auxotrophic mutants.It was not possible for us to find B. bronchiseptica transconjugants in the virulent phase I. All in vivo and in vitro tested parameters showed that the isolated mutants were avirulent in phase III.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100217
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  • 127
    Digitale Medien
    Digitale Medien
    Osnowyi Obschei Mikologii. Kiew: Golownoe Isdatelstwo Isdatelskogo Objedinenija „Vischn Schkola“, 1989 (in Russisch). 590 S., Rbl. 1,40, ISBN 5-11-001357-8 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 192-192 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100219
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  • 128
    Digitale Medien
    Digitale Medien
    Bioproducts and bioprocesses. Second Conference to Promote Japan/U.S. Joint Projects and Cooperation in Biotechnology, Lake Biwa, Japan, September 27-30, 1986. Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer-Verlag, 1989., 377 pp., 182 figs., DM 198,-, ISBN 3-540-50461-3 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 191-191 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100218
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  • 129
    Digitale Medien
    Digitale Medien
    DECHEMA - Monographien. Vol. 113. Steriles Arbeiten in der Biotechnik. Vorträge vom Dechema-Symposium vom 7.-9. Dezember 1987. Weinheim: VCH vertragsgesellschaft, 1987. 288 S. (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 202-202 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100221
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  • 130
    Digitale Medien
    Digitale Medien
    Untersuchungen zur in vitro- und in vivo-Adhärenz von Bordetella bronchiseptica (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 193-201 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Pathogenic strains of Bordetella bronchiseptica undergo phase changing under in vitro conditions. This is the irreversible loss of virulence factors. Adhesins are involved in these structures. They permit adhesion and colonization of bacteria to respiratory epitheliums. Phase III-bacteria adhere as well as Phase I-bacteria under in vitro conditions (cells of respiratory epithelium from guinea pigs).Four phase III-strains of seven isogenic pairs adhere in a significant higher number per cell than phase I-agents. These results are confirmed by results of investigations with phase III-strains constructed throughout cultivation on several culture media. Phase III-bacteria colonize in significant lower numbers under in vivo conditions in rabbits and guinea pigs. Purin auxotrophic mutant strains colonize less in guinea pigs than in rabbits. In vitro adhesion does not reflect the real bacteria-host interaction between adhesin and receptor.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100220
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  • 131
    Digitale Medien
    Digitale Medien
    Masthead (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990) 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100301
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  • 132
    Digitale Medien
    Digitale Medien
    Growth and dinitrogen fixation by azospirillum, species grown under various growth conditions (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 329-336 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The effect of strain specificity, various culturing conditions, and incubation periods on the growth and efficiency of dinitrogen fixation by A. lipoferum and A. brasilense, grown in semisolid N2 malate medium was investigated.The properties of the particular strain markedly affected the proliferation as well as the nitrogen gains of Azospirillum in either growth condition. In A. lipoferum strain 1244 and A. brasilense strrain 1771 the multiplication rates were much higher, the counts reaching 7 × 106 and 9 × 106 cells/ml after 15 days in case of 50/300 ml growth condition, associated with high nitrogen gains reaching 99.8 and 114.3 mgl-1, while in A. lipoferum strain 8670 and A. brasilense strain 5677 the counts were 6 × 105 and 2 × 106 cells/ml after both the same period and growth condition, associated with low nitrogen gains, reaching 62.5 and 69.6 mgl-1, i. e., the amounts of nitrogen fixed is usually linked to cell proliferation. The microbial activity in both nitrogen fixation and oxidation of carbonaceous material is directly reflected on the efficiency of dinitrogen fixation. In all treatments the efficiency of N2-fixation generally increased markedly with time. In A. lipoferum strains 1244 and 8670 the efficiency of N2-fixation was 118.5 and 107.4 in case of 50/100 ml growth condition after 20 days, while in A. brasilense strains 1771 and 5677 the corresponding figures were 126.5 and 115.4. The response of the available oxygen was linked to the growth conditions, accordingly, the efficiency of N2-fixation increased by 4.4% & 8.8% in case of A. lipoferum strains 1244 and 8670, and 11.0% & 9.8% in case of A. brasilense strains 1771 and 5677 as a result of increasing the surface area: depth ratio by altering the volume of medium in the experimental flasks.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100404
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  • 133
    Digitale Medien
    Digitale Medien
    Effect of organic growth factors upon the biomass production of some yeasts (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 349-353 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Some asporgenous yeasts, isolated from various fruits have been examined for their organic growth factor requisites. Of the fifteen growth factors tested, thiamine, biotin, pyridoxine and inositol are the most commonly required organic growth factors by the yeasts, whereas rest of the growth factors showed variable essentiality. All the species of yeasts investigated required different concentrations of growth factors for their optimum growth. Concentration higher than the optimum have been found to be inhibitory for the growth of all the yeasts studied.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100407
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  • 134
    Digitale Medien
    Digitale Medien
    Cassava whey treatment with aspergillus niger (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 341-348 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Treatment of Cassava whey with Aspergillus niger was investigated. Heated cassava whey supplemented with ammonium sulphate (NH4)2SO4 and potassium di-hydrogen phosphate (KH2PO4) called supplemented cassava whey (SUCW); heated but unsupplemented cassava whey (USCW); and cassava whey as is, unsupplemented and unheated (UHCW), were used as waste sources and growth media. Total reducing sugars, starch, total carbohydrate, specific gravity, hydrocyanic acid (HCN), biochemical oxygen demand (BOD) and chemical oxygen demand (COD) of A. niger inoculated samples and uninoculated set were monitored on a time course basis for 5 days using standard methods. Percentage reductions in the BOD and COD were 69.7 and 54.5 respectively for SUCW samples; 42.4 and 29.5 for USCW samples while values for UHCW were 9.0 and 4.5. The reductions in reducing sugars, starch, total carbohydrate, specific gravity and cyanide content in descending order were SUCW; USCW and UHCW. The heated and A. niger inoculated cassava whey samples were better purified than both the unheated but inoculated and unheated and uninoculated cassava whey samples.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100406
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  • 135
    Digitale Medien
    Digitale Medien
    Die europäische Patentanmeldung und der PCT in Frage und Antwort. Köln, Berlin, Bonn, München: Carl Heymanns Verlag KG, 1989, 2nd edition 263 pages; DM 68,- ISBN 3-452-21 286-6 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 354-354 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100408
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  • 136
    Digitale Medien
    Digitale Medien
    Microbial enzymes and biotechnology. Barking, Essex: Elsevier Science Publishers Ltd., 1983, 382 S., 73 Tab., 29 Fig., Ł 49.00 ISBN 0-85334-185-0 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 360-360 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100410
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  • 137
    Digitale Medien
    Digitale Medien
    Purification of human tissue-type plasminogen activator (t-PA) from melanoma cell culture medium by different affinity chromatographic methods (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 355-360 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Supernatants of a melanoma cell line were chromatographed on five affinity supports to evaluate and compare purification protocols for isolation of tissue-type plasminogen activator (t-Pa).t-PA was effectively adsorbed quantitatively from cell culture supernatants by lysine-Sepharose, concanavalin A-Sepharose, zinc-chelate-Sepharose and monoclonal antibody-Sepharose. The major part of t-PA was effectively adsorbed also by heparin-Sepharose. About 20 per cent of t-PA activity present in the culture medium however was not bound to the latter support, which indicates a heterogeneity of melanoma t-PA. The heterogeneity is not due to carbohydrate variants I and II since both vriants were adsorbed and eluted from all the affinity supports investigated.Highly enriched t-PA preparations were obtained by sequential chromatography on two supports. t-PA isolated by monoclonal antibody affinity chromatography and subsequently purified by gel filtration was of highest purity. Other useful combinations were chromatography on concanavalin A-Sepharose or lysine-Sepharose followed by chromatography on heparin-Sepharose, or zinc-chelate-Sepharose followed by chromatography on lysine-Sepharose.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100409
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  • 138
    Digitale Medien
    Digitale Medien
    Purification and partial characterization of external and internal invertases from two strains of trichosporon adeninovorans (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 361-370 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: We investigated the extracellular and intracellular invertase activity of two Trichosporon adeninovorans strains. Both strains (SBUG 724 and CBS 2844) secrete one invertase into the medium. The external enzymes were purified by chromatography on hydroxylapatite. The molecular weight of the external invertase of SBUG 724 was found to be 650,000 and of CBS 2844 450,000. The internal invertases were separated by DEAE-cellulose chromatography. The molecular weight of the enzyme from CBS 2844 was estimated to be 125,000. In the strain SBUG 724 we found two internal invertases (Mr 230,000 and 70,000). The activity of all invertases has similar properties. The pH optimum of the reaction was determined between 5.0 and 5.2 and the temperature optimum was 60 to 70°C. The Km value for sucrose was determined to be 71 to 83 mM and for raffinosc 27 to 36 mM.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100411
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  • 139
    Digitale Medien
    Digitale Medien
    Intensification of glucose oxidase synthesis with aspergillus niger by the way of multistage mutagenization (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 371-376 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Conidia of glucose oxidase active Aspergillus niger G 13 strain were subjected to the fourth-stage mutagenization using different combinations of mutagens in each stage (stage I - UV radiation + nitrosomethylurea, stage II - UV radiation + ethyleneimine, Stage III - acryflavine, stage IV - UV radiation + N-methyl-N′-nitrosoguanidine). In all, 400 strains which showed higher glucose oxidase activity with our own diffusion data method (were isolated out of 5208 colonies after mutagenization). Nine most active mutants were tested in the submerged culture determining the activity of glucose oxidase in the post-culture liquid which increased from 10.7 to nearly 30%.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100412
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  • 140
    Digitale Medien
    Digitale Medien
    Masthead (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990) 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100501
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  • 141
    Digitale Medien
    Digitale Medien
    Production of active mutant strains of penicillium canescens 20171, forming complex preparation of exogenous glycosidases (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 377-381 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The ability to synthesize extracellular β-galactosidase (EC 3.2.1.23), α-galactosidase (EC 3.2.1.22), β-fructofuranosidase (EC 3.2.1.26) in Penicillium canescens mutant strains (300 cultures) after UV-irradiation has been checked. Most of the investigated mutants had the ability to produce the mentioned enzymes in an increased amount in comparison with initial strain. The ability of extracellular enzyme biosynthesis in P. canescens mutant strains was increased for α-galactosidase on 200%, for β-galactosidase on 275% and for β-fructofuranosidase-220%. The mutant strains were stable during three years of observation, complitely maintaining increased activity.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100413
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  • 142
    Digitale Medien
    Digitale Medien
    Dihydrodipicolinate synthase of lysine excreting and non excreting strains of bacillus megaterium (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 382-384 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Dihydrodipicolinate synthase activity of lysine producing strain of Bacillus megaterium and its high yielding mutant AECr 60f was highest during the end of the exponential phase and remained at the same level during the stationary phase when major bulk of lysine was accumulated. In comparision in a lysine non producing strain of B. megaterium the activity of the enzyme was low. Lysine producing strains has DHD synthase with two specialities, persistence during the stationary phase and insensitivity to repression by exogenous lysine. The high yielding mutant has increased DHD synthase activity which was not sensitive to feed back inhibition with lysine.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100414
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  • 143
    Digitale Medien
    Digitale Medien
    Entwicklung der biotechnologie in der UdSSR. Moskau: Verlag Nauka, 1988, 200 S., 6 Abb. (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 34-34 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100109
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  • 144
    Digitale Medien
    Digitale Medien
    Interbiotech '87, enzyme technologies, progress in biotechnology vol. 4. Amsterdam, Oxford, New York, Tokyo: Elsevier Science Publishers. 1988, S. 535, $ 171.00 Dfl325.00, ISBN 0-444-98 924-2 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 40-40 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100111
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  • 145
    Digitale Medien
    Digitale Medien
    Adhesins of escherichia coli (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 151-161 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: E. coli has got increasing importance as a causative agent of intestinal and extra-intestinal diseases. In both these infections adhesion of the bacteria to mucous surface cells are initial events for coionization and development of infection. Adhesins are bacterial recognition proteins which specifically interact with carbohydrate moieties of glycoproteins or glycolipids on mammalian cells. The adhesiveness of bacteria is associated with filamentous surface appendages, designated as fimbriae or pili, as well as with non-fimbrial components. Some recent data on the nomenclature, classification, disease association, receptor specificity, and topographic arrangement are presented. The correlation between E. coli O : K : H serovar and fimbrial antigens is demonstrated on the basis of E. coli isolated from patients with urinary tract infections. Hitherto unknown non-fimbrial adhesins are briefly described.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100211
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  • 146
    Digitale Medien
    Digitale Medien
    Nachweis humoraler und lokaler Antikörper nach Einsatz einer bordetella Bronchiseptica-Lebendvakzine am Schwein (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 179-184 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The aim of this work was to prove if a Bordetella bronchiseptica living vaccine is able to induce humoral and local antibodies in pigs. The living vaccine was compared with a killed Bordetella bronchiseptica adjuvans vaccine. The results show that piglets of sows vaccinated parenterally with living vaccine and killed adjuvans vaccine develop a stronger humoral immune reaction than piglets vaccinated locally with living vaccine. Sows immunized parenterally with living vaccine permint their piglets in the first three weeks colostral antibodies like sows immunized with killed adjuvans vaccine. The living vaccine induces especially local antibodies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100216
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  • 147
    Digitale Medien
    Digitale Medien
    VCH forschungsführer. Chemie und biochemie in der bundesrepublik deutschland. Weinheim, Basel, Cambridge, New York: VCH Verlagsgesellschaft, 1989. 673 pp., DM 196,-, ISBN 3-527-26809-x (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 178-178 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100215
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  • 148
    Digitale Medien
    Digitale Medien
    Comparison of mitotic activity and growth in two long term callus cultures of matricaria recutita L. (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 245-251 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Callus cultures of two tetraploid plant of Matricaria recutita L. were initiated from leaves and cultured on LINSMAIER-SKOOG culture medium supplemented with 0.01 mg · 1-1 IAA or 3.00 mg · 1-1 2, 4-D for three years. The relationship between mitotic activity and growth of calli was studied. The time at which mitotic activity began in both cultures was different. In the callus culture cultivated on the medium with IAA the maximum mitotic activity was observed on the 14th to 17th day of subculture. In the one cultivated on the medium with 2,4-D, the increase of mitotic activity was observed earlier and corresponded with the beginning of exponential growth. In addition of total mitotic activity individual mitotic phases have also been evaluated. Most mitotically active cells in both cultures were in prophase. Their courses were similar to those of total mitotic activity. Metaphase and telophase stages were present in low frequency. Anaphase occured rarely. The functional dependences of mitotic activity and growth were characterized by appropriate mathematical models.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100306
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  • 149
    Digitale Medien
    Digitale Medien
    Patentgesetz. 4th revised and enlarged edition Köln, Berlin, Bonn, München: Carl Heymanns Verlag KG, 1987. 987 p., DM 140,-, ISBN 3-452-20944-x (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 540-540 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100614
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  • 150
    Digitale Medien
    Digitale Medien
    Characteristics of the immobilized pectin lyase activity from a commercial pectolytic enzyme preparation (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 531-539 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A commercial pectolytic enzyme preparation has been immobilized onto a nylon-polyethyleneimine copolymer, in order ot study the contribution of the pectin lyase activity inthe overall pectindegrading activitg. Optimal conditions for the immobilization process of the pectin lyase activity, such as chemical modification of the support, coupling pH and protein concentration, were determined.Kinetic parameters and temperature behaviour of both the soluble and immobilzied pectin lyase activitgy of the derivative were also determined. OPerational stability of the pectin lyase and overall viscosity reducring activities resulting in a halflife times of 3.8 and 8.5 days, respectively, for both pectolytic activities, when the immobilized derivatives were tested in a cross-flow reactor, using a highly esterified pedtin as substrate.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100613
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  • 151
    Digitale Medien
    Digitale Medien
    Genetics of bacterial diversity. London, New York, Tokyo: Academic Press, 1989. 449 pp., Ł 14.95, ISBN 0-12-355574-4 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 550-550 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100616
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  • 152
    Digitale Medien
    Digitale Medien
    Investigation of the connection between the electrophoretic mobility (EPM) of microorganisms and their capability of metal uptake (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 541-549 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The electrophoretic mobility of microorganisms (EPM) as a measure of their electric surface charge was determined as a function of different milieu conditions with the aid of the “Parmoquant 2” cell electrophoresis apparatus manufactured by CARL ZEISS Jena.The object of these researches was to examine the influence of the electric surface charge of microorganisms on their metal loading capacity. The results show a direct correlation between the electric surface charge or the EPM of microorganisms and their maximum metal loading capacity. Cells with a high negative surface also posses a high metal binding capacity. On the other side only a negligible metal uptake can be observed at the isoelectric point of the microorganisms (EPM = 0). The method of cell electrophoresis proved suitable to analyze complex interactions between microorganisms and heavy metal ions.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100615
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  • 153
    Digitale Medien
    Digitale Medien
    Separations for biotechnology. Chichester: Ellis Horwood Ltd. 1987, 502 S., 179 Abb., Ł 55.00 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 560-560 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100618
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  • 154
    Digitale Medien
    Digitale Medien
    Methods in molecular biology. Vol. 4: New Nucleic Acid Techniques. Clifton, New Jersey: Humana Press, 1988. 560 pp., Ł 42.00, isbn 0-89603-127-6 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 564-564 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100622
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  • 155
    Digitale Medien
    Digitale Medien
    Biotechnology at the treshold of the XXI century - ‘acta biotechnologica‚ is entering its second decennium (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 3-5 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100102
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  • 156
    Digitale Medien
    Digitale Medien
    Progress in industrial microbiology. Vol. 25. Computers in fermentation technology. Amsterdam, Oxford: Elsevier, 1988. 198 pp., $ 73.75, Dfl. 140.00, ISBN 0-444-429794 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 6-6 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100103
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  • 157
    Digitale Medien
    Digitale Medien
    Genetics of Translation. New approaches. NATO ASI Series H: Cell Biology, Vol. 14. Berlin, Heidelberg, New York: Springer-Verlag, 1988. 524 S., 145 Abb., Dh 248,-ISBN 3.540.18550-X (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 12-12 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100105
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  • 158
    Digitale Medien
    Digitale Medien
    Bioprocesses including animal cell culture. Berlin: Akademie-Verlag, DDR, 1988. 168 S., 41 Fig., 12 Tab., M. 148,-, ISBN 3-05-500569-4 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 22-22 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100107
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  • 159
    Digitale Medien
    Digitale Medien
    The principle of optimality as the foundation of biotechnological modeling (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 23-34 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: There are many points of contact between optimization problems and modeling. On the one hand the model adjustment process itself as a process of estimation is closely connected with optimization, in that it is to produce what is in one sense the best possible model. The basic structure of the optimization problem as problem in decision making with the necessary input of an objective function is thus evident. On the other hand a model is never an end in itself but on the basis of its simulation capacity a means to an end, for example in biotechnological optimization. From this point of view the model is a product of scientific work and thus an economic value. Equally, through its intended purpose the model exhibits a utility value. A complete evaluation of the model as a condition of rational modeling must take into account both these aspects. That is possible in principle by adding the modeling expenditure to expenditure for the realization of biotechnological processes, expressing the economic consequences of model quality as an objective function, and minimizing the specific total expenditure for the product to be produced.Biotechnological practice requires that the “optimum” model is approached by means of iterative processes. Some practical examples will make the process clear, taking into account qualitative (semantic) and quantitative (accuracy) aspects of the utility value.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100108
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  • 160
    Digitale Medien
    Digitale Medien
    Microbial proteinases. The amidase from a brevibacterium strain: Study and applications. Advances in biochemical engineering/biotechnology. Vol. 36 Enzyme studies. Berlin: Akademie-Verlag, 1988. 115 S., M 108,-, ISBN 3-05-500568-6 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 48-48 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100113
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  • 161
    Digitale Medien
    Digitale Medien
    Antibiotic resistance genes: Ecology, transfer, and expression. Banbury Report 24. Cold Spring Harbor: Cold Spring Harbor Laboratory, 1987, S 68,00, XIV, 436 pp. ISBN 0-87969-224-3 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 54-54 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100115
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  • 162
    Digitale Medien
    Digitale Medien
    Fructose phosphorylation by zymomonas mobilis glucokinase (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 49-53 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Zymomonas mobilis ATCC 53431, a fructokinase negative mutant is unable to utilize fructose as a sole carbon source for growth. At high fructose concentrations, however, fructose was converted to ethanol. The fructose uptake displayed MICHAELIS-MENTEN kinetics with an apparent Km of 185 mM fructose.Purified glucokinase from ATCC 53431 and the wild strain ATCC 29191 both exhibited fructose phosphorylating activity at high fructose concentrations with an apparent Km value of 222 mM fructose. Glucokinase substrate specificity was found not be absolute, as previously reported.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100114
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  • 163
    Digitale Medien
    Digitale Medien
    Isolation of auxotrophic mutants and development of conjugation system in KISR methylotrophs (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 93-98 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Isolation of auxotrophic mutants and conjugal transfer of plasmids are successfully demonstrated in four obligate methylotrophic strains isolated at Kuwait Institute for Scientific Research (KISR)Out of 11 auxotrophic, mutants, three required methionine and two leucine. Complete transfer of plasmid R68.45 from Pseudomonasto KISR methylotrophs and vice versa have been achieved with a low transfer rate.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100123
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  • 164
    Digitale Medien
    Digitale Medien
    The microbiological data base of the data bank project BD1 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 79-84 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The aim of the project BD1 (Biotechnology Data Bank 1) is to improve the data processing for research in biotechnology. In BD1, data of several classes of objects and methods are compiled. A data file conception consisting of object data files, method data files and feature data files was created, which can be easily extended to further classes, and which allows the combination of different classes of features to the same class of objects. There are two main approaches to use BD1: 1. making available informations on certain biotechnological objects, 2. the identification of unknown objects by means of their feature pattern.The microbiological data base and the possibilities of data base search are presented by example of lactic acid bacteria.
    Zusätzliches Material: 7 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100121
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  • 165
    Digitale Medien
    Digitale Medien
    Nonionic tensides modify papain structure and proteolytic activity (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 85-92 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The effect of 33 polyethoxylated nonionic tensides with various hydrophobic moieties was studied on the proteolytic activity and phase transition behaviour of papain. Tensides with longer ethyleneoxide chain markedly increased the phase transition temperatures of papain indicating possible hydrogen bond formation between the hydrophilic ethyleneoxide chain and the polar substructures of papain. The character of lipophilic moiety of tensides influences also each physicochemical parameter of papain suggesting the existence of hydrophobic interactions too. The significant positive linear correlations between the activity increasing and structure stabilizing effects of tensides make probably that the structure modification of papain accounts for its enchanced proteolytic activity.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100122
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  • 166
    Digitale Medien
    Digitale Medien
    Heterotrophic eubacteria isolated from cultures of the cyanobacterium, spirulina maxima (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 99-104 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Three distinct heterotrophic eubacterial strains were isolated from mixotrophic cultures of the filamentous cyanobacterium, Spirulina maxima (Gom) Geitl. Spirulina spp. are considered to be prime candidates for the phototrophic production of biomass protein, particularly in developing countries. These cyanobacteria are extreme alkaliphiles and halophiles, making their production in arid regions promising.Most previous studies on the eubacteria which live in Spirulina culture systems have focused on determining the possible presence of pathogenic species in biomass protein. Little has been done to understand the symbiotic relationships between the cyanobacterium and its eubacterial cosymbionts. From the perspective of a heterotrophic eubacterium, autotrophic cultural systems of Spirulina have limited carbon and energy resources, being limited to cyanobacterial exudates.In this study, three eubacterial strains were isolated and studied. One strain, a Gram-negative, non-sporing, motile rod, grew exceptionally well in a mineral salts medium where only a small amount of a single low molecular weight organic compound (e.g., acetate) was supplied as sole energy source. This strain was also extremely euryresponsive with respect to salinity and alkalinity as well. Two less well-adapted eubacterial strains are also described.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100124
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  • 167
    Digitale Medien
    Digitale Medien
    Masthead (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990) 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100201
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  • 168
    Digitale Medien
    Digitale Medien
    Plant cell biotechnology. (NATO ASI series H: Cell Biology, Vol. 18). Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer-Verlag, 1988 500 pp., 92 figs., DM 298.00, ISBN 3-540-18 556-9 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 104-104 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: NO ABSTRACT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100125
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  • 169
    Digitale Medien
    Digitale Medien
    Safety assurance for environmental introductions of genetically-engineered organisms. (NATO AS1 series G: Ecological sciences, Vol. 18). Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer-Verlag, 1988. 282 pp., DM 148,-, ISBN 3-540-18561-5 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 116-116 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100203
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  • 170
    Digitale Medien
    Digitale Medien
    Techniques in cell cycle analysis. Clifton, New Jersey: Humana Press Inc, 1987. 407 pp., S 79.50, ISBN 0-89603-097-0 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 124-124 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100205
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  • 171
    Digitale Medien
    Digitale Medien
    Significance of composition and structure of the enterobacterial outer membrane to the transport of desired and undesired substances and its inhibition (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 107-115 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The enterobacterial outer membrane forms a bilayer. Its outer monolyer consists of lipopolysaccharides and proteins, its inner monolayer of phospholipids and proteins. It thus represents an efficient penetration barrier against hydrophobic and anionic compounds (such as detergents or hydrophobic antibiotics) and against higher molecular substances (such as proteolytic, lipolytic, and murolylic enzymes).Some of the proteins (“porins”) form channels through the outer membrane through which neutral and cationic hydrophylic compounds up to a molecular weight of about 800 can pass. Besides the porins additional transport systems have been described. They play an important part in providing the bacteria with substances necessary for their growth, i.e., phosphate, iron ions, and others.Organic polycations are able to generate more or less severe disorganizations in the outer membrane through which they can pass the bilayer (“self-promoted pathway”). Some of these polycations represent efficient antibiotics (polymyxin B, nourseothricin). Bacteria are able to protect themselves against the harmful action of these substances by changing the composition of the outer membrane.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100202
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  • 172
    Digitale Medien
    Digitale Medien
    Outer membrane vesiculation of acinetobacter calcoaceticus (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 117-123 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: For intact cells of A. calcoaceticus 69V susceptibility to hydrophobic agents (antibiotics, dyes) was established. The composition of its outer membrane and comparison with that of a reference strain, A. calcoaceticus CCM 5593 with a blocked hydrophobic pathway, gave no indication of phospholipid bilayer domains as the structural basis of these permeability characteristics. The outer membrane composition together with the data of time-resolved fluorescence anisotropy measurements is indicative of a high state of order of the hydrocarbon region.A. calcoaceticus 69V releases lipopolysaccharide (LPS)-rich membrane vesicles into the growth medium when grown on a hydrophobic carbon source. While the cells contain both R-form and S-form LPS, the LPS released with the vesicles is exclusively of the R-type. The same selectivity with respect to LPS composition was observed when LPS was removed from intact cells by EDTA-NaCl treatment which leads to a break-down of the barrier to hydrophobic agents in A. calcoaceticus CCM 5593.We propose that due to its physical properties, R-form LPS forms tightly packed structures within the membrane which, under certain conditions, become destabilized and liberated into the surrounding medium. As a consequence, a disturbance of the highly ordered lateral molecular arrangement might lead to altered permeability properties of the outer membrane as suggested in one of the two alternative models existing to explain permeability changes observed in deep rough mutant strains of Enterobacteriaceae.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100204
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  • 173
    Digitale Medien
    Digitale Medien
    Yeast genetics. A manual of methods. Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer-Verlag, 1989. 104 pp., 10 fig., DM 59,-, ISBN 3-540-18805-3 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 142-142 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100208
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  • 174
    Digitale Medien
    Digitale Medien
    Structure and serology of the lipopolysaccharides: Cell components of citrobacter (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 133-141 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The genus Citrobacter consists of enteric rods that utilize citrate as a sole carbon source. Citrobacter serotypes are normal intestinal inhabitants, but some of them have been reported in gastroenteritis and in extraintestinal infections.Our immumochemical studies on Citrobacter lipopolysaccharides of chemotype G comprised serotypes: 04, 027 and 036. As we found the serotypes mentioned above are distinguished in having O-specific polysaccharides that are homopolymers of β [1-2] linked 4-deoxy-D-arabinohexopyranose. In accordance with the structural indentity, the Citrobacter lipopolysaccharides showed strong serological cross-reactivity. Nevertheless, serotypes 04, 027, and 036 form separate entities, as observed in early studies of serologists. To find the reason for the immunological diversity the structural studies on lipopolysaccharide core regions of these Citrobacter serotypes were carried out. Three novel enterobacterial cores were identified. The complete cores 04 and 036 are decasaccharides differing in one structural element only: side-chain glucose is present in 04 oligosaccharide in the place of galactose in the 036. The core 027 is octasaccharide.In conclusion, our structural studies have shown hitherto that in Citrobacter chemotype G group only one O-specific polysaccharide, but three core regions, exist.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100207
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  • 175
    Digitale Medien
    Digitale Medien
    Identification of D-galactose-(1 → 7)-3-deoxy-d-manno-2-octulo-pyranosonate as component of the inner core region of escherichia coli EH 100 lipopolysaccharide (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 163-168 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The dissaccharide D-galactosyl-3-deoxy-D-manno-2-octulosonic acid (Gal-KDO) from lipopolysaccharides (LPS) of the inner core region of the rough mutant EH100 of E. coli 0100 was isolated after mild acid hydrolysis of LPS by means of dialysis, ion-exchange chromatography, gelfiltration and high-voltage paper electrophresis. By chemical analysis galactose and KDO were identified in a molar ratio of approximately 1 : 1. 13C-NMR and 1H-NMR studies, methylation analysis and GLC of the acetylated R.( - )-2-butyl-galactoside identified the structure .
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100213
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  • 176
    Digitale Medien
    Digitale Medien
    Some aspects of the regulation of nitrogen metabolism in the yeast genus candida. Study of the kineties of ammonium transport to the cells of hydrocarbon oxidizing yeast of the genus candida with a change in nitrogen nutrition (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 169-177 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: In his study the kinetics of the ammonium transport to he hydrocarbon-oxidizing yeast cells and the specific features of its regulation as one of the aspects of catabolite nitrogen repression were investigated. As the objects 3 mesophilic strains of C. maltosa, the thermotolerant strain C. rugosa as well as a collection of the thermotolerant strain C. blankii BKM-Y-462 type were selected.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100214
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  • 177
    Digitale Medien
    Digitale Medien
    Effect of ensiling on the nutritive value of low quality roughage rice hulls. I. Microbial studies (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 419-432 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Rice hulls were ensiled in laboratory silos in two separate experiments with the same treatments. In the first, sealing was delayed for a period of days. In the second experiment, silos were sealed immediately after filling. In each experiment, four treatments were applied, namely control, molasses 2% added, urea 0.5% added, and molasses 2% + urea 0.5% added.Lactobacilli, streptococci, and coliforms appear to form the main bulk of the flora characteristic of fresh rice hulls, while the lactic acid bacteria dominate at the commencement of the silage ripening. The characteristics of 30 representative pure strains of both lactic acid and coliform bacteria isolated from rice hulls laboratory silage are described. On the basis of morphological, cultural, and biochemical characteristics, the isolated cultures were identified as ten strains of Lactobacillus ten strains of Streptococcus, five strains of Klebsiella, and five strains of Escherichia.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100508
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  • 178
    Digitale Medien
    Digitale Medien
    Römpp Chemie Lexikon (9th edition). Stuttgart, New York: Georg Thieme Verlag, 1989. 6 Volumes (1989-1992), 40,000 entries, DM 1188,- (subscription rate) Vol. 1 (A-Cl). 762 pp., DM 198,-, ISBN 3-13-734609-6 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 444-444 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100511
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  • 179
    Digitale Medien
    Digitale Medien
    Continuous culture models with intermediates (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 433-443 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The number of stability of steady states of minimal structured models are determined theoretically. Regulation of two “bottle-necks” of cell metabilism by extracellular or intracellular or intracellular intermediates is suggested. The mechanisms of this regulation include substrate and product feed-forward inhibition as well as feedback product control. The most complex system behaviour is obtained in models with feed-forward intermediate inhibition. In particular these models exhibit multistability and two limit cycles.The maximum number of steady states decreases from five to four when the extracellular intermediate is changed by the intracellular one. The number of non-zero steady states is changed from four to two.The relevant features of phase-portrait appear to be independent of the choice of reaction rates. Therefore our results are suitable for a large group of the third order modles. The possibility to verify the theoretical predictions experimentally is also discussed.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100510
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  • 180
    Digitale Medien
    Digitale Medien
    Progress in clinical biochemistry and medicine, Volume 5. Berlin: Akademie-Verlag, 1988. 240 pp., 59 fig., DM 128,-, ISBN 3-05-500395-0 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 450-450 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100513
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  • 181
    Digitale Medien
    Digitale Medien
    Influence of acid phosphatase activity on the saccharification of potato maltodextrins by aspergillus niger glucoamylase (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 445-449 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A preparation of Aspergillus niger acid phosphatase, which had the temperature optimum 60°C, pH optimum 1.8-3.0; good stability at pH 4-5, the ability to hydrolyze glucose-6-phosphate at a high rate, and substantial lack of glucogenic activities, was used simultaneously with a glucoamylase in order to learn its influence on the saccharification of potato maltodextrins.The addition of the acid phosphatase activity in amounts that gave the 50 fold increase, as compared to phosphatase activity which naturally occurs in the glucoamylase (GA) preparation ‘AMG-200’, was found to influence on the DE level, mainly at the high substrate concentration (40% d.s.) and low glucoamylase dosage (60-100 GAU/kg d.s.). It may also be possible, when using the acid phosphatase addition, to shorten the saccharification time.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100512
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  • 182
    Digitale Medien
    Digitale Medien
    Classification of yeasts by means of the BD1 data bank (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 401-410 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Computerized procedures for the classification and discrimination of yeasts are presented which base on feature data files and classification techniques involved in a data bank project (BD1). Microbiological (physiological and morphological) and analytical feature data classes (fatty acid patterns from gas chromatography, fourier coefficeints from FTIR spectra, fluorescence patterns) were used to show the possibilities of yeast classification, carried out by means of these features and statistical or non-statistical methods. Results obtained by a suitable combination of these methods are presented.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100505
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  • 183
    Digitale Medien
    Digitale Medien
    Influence of cytochrome composition on the energy conservation of acinetobacter calcoaceticus 69-V (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 551-560 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Acinetobacter calcoaceticus 69-V contained cytochromes b, o, d and traces of cytochrome a1 after growth on ethanol. Cytochromes o, d, and a1 are known to be potentially capable of functioning as terminal oxidases. After growth on acetate only smaller amounts of cytochromes b and o were detectable. Cytochrome spectra of acetate plus glucose-grown cells resembled more those of ethanolgrown cells. Cytochrome spectra of acetate plus ethanol-grown cells were more similar to those of acetate-grown cells but already showed small amounts of cytochrome d.Ethanol-grown cells were energized only by the oxidation of glucose. But the velocity of ATP synthesis was so low that the P/O quotient amounted to practically zero. The stoichiometries of ATP synthesis of the otherwise-grown cells were generally higher for the oxidation of glucose than for the oxidations of succinate and D-lactate. Similar high P/O quotients were measured for the oxidations of glucose and ethanol in acetate plus ethanol-grown cells.No significant energization could be observed during the oxidations of gluconate and acetate.The findings indicate that electrons delivered by the PQQ-dependent glucose as well as by NAD+- dependent ethanol oxidations have probably a common place of entry into the respiratory chain. Glucose and NADH appeared to be energetically equivalent although at least two energetically different pathways might be involved in substrate oxidation.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100617
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  • 184
    Digitale Medien
    Digitale Medien
    Römpp Chemie Lexikon (9th edition). Stuttgart, New York: Georg Thieme Verlag, 1990. 6 Volumes (1989-1992), 40,000 entries, DM 1188.- (subscription rate) Vol. 2 (Cm-G), pp. 763-1678, DM 198,-, ISBN 3-13-734-709-02 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 561-561 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100619
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  • 185
    Digitale Medien
    Digitale Medien
    Symmetry through the eyes of a chemist. New York: VCH Publishers, Inc. 458 pp., 380 photographs, figures and drawings (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 62-62 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100117
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  • 186
    Digitale Medien
    Digitale Medien
    FERM - a decision support system for fermentation processes (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 63-71 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: For recombinant DNA product fermentations in the laboratory and pilot scale as well as for antibiotic fermentations at the industrial scale decision support program systems for personal computers were developed. It assists the operator to solve control and decision tasks. Applying this program the data and knowledge bases increase, which include measured and derived process data, parameters and comments of previous fermentation runs as well as algorithmic and declarative rules.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100118
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  • 187
    Digitale Medien
    Digitale Medien
    Patents: A basic guide to patenting in biotechnology. (Cambridge Studies in Biotechnology: 6). Cambridge: Cambridge University Press, 1988. 191 S., $ 49.50, ISBN 0521-32954-X (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 72-72 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100119
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  • 188
    Digitale Medien
    Digitale Medien
    Ethanolic fermentation with saccharomyces cerevisiae cells immobilized in pectate gel (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 55-61 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: High-molecular weight pectic acid with a STAUDINGER index of 210 ml/g and a degree of esterification of 3%was used as matrix material for the immobilization of Saccharomyces cerevisiae cells. In discontinuous and continuous fermentation tests the gel beads obtained exhibited the same biomass loading capacity (152-155 g dry wt. cells/kg gel) and about the same maximum specific productivity (103.0 g ethanol/kg gel · h) as alginate immobilizates. But there were distinct differences in the swelling behaviour of the two gels. Under the same experimental conditions the increase of bead volume amounted to 27% only for pectate gel in comparison to 129% for alginate gel. In continuous fermentation experiments performed in a horizontal-column packed-bed reactor with liquid recycling a mean steady-state ethanol concetration of 69.1 g/l and a mean productivity of 24.7 g ethanol/lh could be kept constant over a period of more than 10 days.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100116
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  • 189
    Digitale Medien
    Digitale Medien
    Effects of temperature on the growth of the thermotolerant methylotrophic bacillus sp. NCIB 12522 in chemostat culture (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 73-78 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The effects of temperature on chemostat cultures of a thermotolerant, methylotrophic Bacillus ap. are reported. In spite of the relative fastidiousness of this bacterium, overall response to a range of growth temperatures is predictable. However, anomalous results with respect to biomass yield coefficients are evident, suggesting complex and extensive endogenous and exogenous activities under some growth conditions.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100120
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  • 190
    Digitale Medien
    Digitale Medien
    Biotechnologie - Lehrbuch der angewandten Mikrobiologie. Dritte, neubearbeitete Auflage. München, Wien: R. Oldenbourg Verlag, 1989 342 S., 224 Abb., 342 Tab., DM 76,-, ISBN 3-486-28403-7 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 150-150 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100210
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  • 191
    Digitale Medien
    Digitale Medien
    Untersuchungen zur Oberfläuchenstruktur von Pasteurella multocida (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 143-149 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Detailed studies of the surface structures are an important requirement for the development of efficient vaccines against enzootic pneumonia in calves and piglets caused by Pasteurella multocida.Electron microscopical examination after Alcian Blue staining shows capsular material extending far into the surrounding medium.The extent of the capsules depicted by light microscopy did not correlate with virulence and immunogenicity. However, the extent of the capsules was effected by different culture conditions.The immunization with extract material resulted in a good protection against homologous infection.It has been shown that different cultivation conditions can result in heterogeneity of LPS and in altered OMP-profiles.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100209
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  • 192
    Digitale Medien
    Digitale Medien
    Bioorganic marine chemistry, Vol. 2. Berlin, Heidelberg, New York, London, Paris, Tokyo: Springer-Verlag, 1988. 170 pp., 9 fig., 12 tab., DM 118,-, ISBN 3-540-19357-X (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 162-162 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100212
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  • 193
    Digitale Medien
    Digitale Medien
    Brauchbarkeit der ATP- und Dehydrogenaseaktivitätsmessungen, und der Sauerstoffverbrauchsgeschwindigkeit zur Intensitätsbeurteilung des Belebtschlammverfahrens (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 203-212 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Some measurements of the metabolic activity of microorganisms in a standard activated sludge system have been made. The investigations have shown that the measurements of the respiratory activity of microorganisms are a convenient and reliable method for determining the metabolic activity of microorganisms. The values of respiratory activity have shown a high correlation with the rate of substrate removal in a continuous activated sludge process. Hydrogenase activity has shown moderate correlation with the rate of substrate removal.The ATP values did not correlate with any of the methods of measuring the metabolic activity of microorganisms and the quantity of the dry organic mass of activated sludge. Howeever, the highest correlation between the particular parameters of the activated sludge process was obtained after assuming that the ATP total corresponds to the quantity of the active biomass which fact points at the correctness of such an assumption.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100222
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  • 194
    Digitale Medien
    Digitale Medien
    Fungal cell walls: Their structure, biosynthesis and biotechnological aspects (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 225-238 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The article briefly reviews the present knowledge on various aspects of fungal cell wall structure, function and biosynthesis of its individual components. A special attention is devoted to biotechnological potential of cell walls and cell-wall linked phenomena.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100303
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  • 195
    Digitale Medien
    Digitale Medien
    Modelling of the calculation of the power input for aerated single- and multistage impellers with special respect to scale-up (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 215-224 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: For both laboratory and industrial scale fermenters the stirred fermenter is often being used. Especially for the design procedure of industrial fermenters with variable speed drive it is important to know the exact power characteristics for single and multiple impellers. The calculation procedure used for estimating the gassed power input gives the possibility to calculate the gassed power drawn by at maximum 3 impellers in vessels up to 3.5 m in diameter in aerated water. For calculation one only needs known parameters. This power input is valid for low and medium viscous fermentation broths too because especially after the addition of antifoam agents the properties of the liquid phase are then comparable to water as a coalescing liquid. It is possible to calculate the gassed power drawn by each impeller of a multiple system. This calculation procedure is applicable to different fermentation broths where in the range of low aeration rates the results differ from those for water.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100302
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  • 196
    Digitale Medien
    Digitale Medien
    Die gelenkte Biosynthese immunogener Strukturen für die Impfstoffproduktion am Beispiel Bordetella bronchiseptica (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 239-243 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: It is described how Bordetella bronchiseptica forms biomass mainly from L-glutamic acid and L-proline. Glucose-6-P is prepared by gluconeogenesis with the aforesaid amino acids and by phosphorylization of starch by phosphorylase and cAMP serving as signal substance. Synthesis of the heatsensitive toxin is mainly effected by yeast extract and a trypton at low redox potential. The capsule is synthesized by nicotinic acid amide, peptides, glycerol, glucose, ascorbic acid, and Mn-ions. The fimbria development is positively influenced by the taurine, L-glutamic acid, L-histidine, and polysaccharides, The necessary immunobiological parameters for vaccines are optimally developed by Bordetella bronchiseptica when observing the requirements for cultivation.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100304
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  • 197
    Digitale Medien
    Digitale Medien
    Membrane biogenesis. NATO ASI Series H.: Cell Biology. Nr. 16. Berlin: Springer-Verlag, 1988. 477 S., 160 Abb., DM 238,-, Isbn 3-540-18566-6 (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 244-244 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100305
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  • 198
    Digitale Medien
    Digitale Medien
    Verzeichnis bibliographischer Datensammlungen und Datenbasen zu Grundlagen- und Anwendungsgebieten der Biotechnologie. (Directory of Bibliographic Data Bases in Biotechnology). Berlin: Akad. Wiss. DDR, Wissenschftl. Inform.-Zentrum, 1989. 110 pp. (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 252-252 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100307
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  • 199
    Digitale Medien
    Digitale Medien
    Anwendung von Methoden der Mustererkennung bei mikrobiell hergestellten Trockenproduktchargen (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 253-260 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The application of methods of Pattern Recognition makes it possible to classify dehydrated SCP-products which were produced under various conditions of production by a low number of signs. These mathematical methods not only allow to draw technological conclusions but also to decide on correctness of the way to produce suitable SCP-products for feeding of monogastric animal species. There are a large number of possibilities to use these methods of Pattern Recognition in the field of biotechnological research.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100308
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  • 200
    Digitale Medien
    Digitale Medien
    Purification and immobilization of the inducible form of extracellular laccase of the fungus trametes versicolor (1990)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 10 (1990), S. 261-269 
    Details
    ISSN: 0138-4988
    Schlagwort(e): Life Sciences ; Life Sciences (general)
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The inducible form of extracellular laccase (EC 1.10.3.2) produced by Trametes versicolor culture in a 10 1 glass fermenter was isolated and purified by ion-exchange chromatography on the DEAE-Sephadex A-50 column and by affinity chromatography on a syringyl-CPG column. The enzyme was further immobilized on functionalized porous glass. The paper also discusses some properties of immobilized and free enzyme, respectively.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/abio.370100309
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