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  • 1960-1964  (4,942)
  • 1890-1899  (2,377)
  • Organic Chemistry  (5,487)
  • Life and Medical Sciences  (1,832)
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  • 1
    Electronic Resource
    Electronic Resource
    Addendum (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 552-552 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480405
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  • 2
    Electronic Resource
    Electronic Resource
    Correlation between morphometric measurements of the aorta and visual scoring of avian atherosclerosisSupported in part by U.S.P.H.S. grants H-3513 and H-3178, the New Jersey Heart Association and by Quartermaster Corps Contract DA-129-9M-1352. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 527-534 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: An analysis was made on 140 adult chickens of the relationship between visual estimation of the degree of encroachment of the lumen of the vessel by plaques and such morphometric variables as weight, length, circumference, thickness, density, and combinations thereof of the thoracic and abdominal segments of the aorta. Aortic weight and thickness functions were found to be significantly correlated to scores, accounting in the two highest cases (thickness and weight/area of the abdominal segment, body weight held constant) for 46% (r = 0.68) and 42% (r = 0.65) respectively, of the variability in score. Correlations were considerably lower in the thoracic segment, the highest being r = 0.36 for weight/circumference. The scoring thoracic segment, the highest being r = 0.36 for weight/circumference. The scoring system thus has a basis in measurable physical changes in the wall of the blood vessel, but scoring apparently evaluates considerably more than was measured by the morphometric variables. The morphometric variables would probably serve best as means of comparing different scoring systems and as objective supplements to scoring. The procedure of choice would appear to be weight/area with body weight held constant (i.e.  -  partial correlation and/or covariance analysis).
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480402
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  • 3
    Electronic Resource
    Electronic Resource
    Etiology of trypan blue induced antenatal hydrocephalus in the albino rat (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 561-571 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Wistar strain albino rats were injected with 1 cm3 of a 1% solution of trypan blue. Three types of dye were used: Matheson, Coleman and Bell, Chroma-Gesellschaft and a highly purified sample. The dyes were injected on days 6, 7, and 8 of gestation. Fetuses were excised from days 16 through 20, fixed, decalcified where necessary, embedded in paraffin, serially sectioned and stained. Newborn young were treated similarly. Chroma-Gesellaschaft trypan blue was without reproductive or teratogenic effect at the above doses. Increasing the dose did not increase the teratogenicity but did yield a decrease in litter size. Both Matheson, Coleman and Bell trypan blue and the purified sample were teratogenic. The most frequent neural defect observed was hydrocephalus. Serial sections of the newborn hydrocephalics showed an occluded or extremely tenotic aqueduct of Sylvius in 31 of 33 sectioned animals. The fetuses collected from days 18 through 20 also had occluded or stenotic aqueducts if hydrocephalic. Aqueductal stenosis or occlusion was present in 17-day-old fetuses, but hydrocephalic was not conclusively demonstrated at this age. Sixteen-day-old fetuses did not have aqueductal occlusion in any of those examined, but stenosis was evident. It is concluded that the defect predisposing to hydrocephalus in the young of trypan blue treated rats of this strain is aqueductal stenosis or occlusion.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480407
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  • 4
    Electronic Resource
    Electronic Resource
    Ovarian follicular development in the pregnant hamster (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 605-609 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Follicular activity in the ovary of the pregnant hamster is divided into two periods. During the first eight days (corresponding to the duration of pseudopregnancy) an average of 11 follicles per ovary from 277 to 553 μ are present. From day 10 to 16 of pregnancy, the ovary contains 22 follicles ranging from 277 to 600 μ and larger. The day after parturition, atresia destroys all large multilayered and vesicular follicles.Hamsters injected with human chorionic gonadotropin on day 4 of pregnancy ovulated ten ova, whereas similary treated day 12 animals ovulated 35 eggs. No cyclic follicular activity corresponding to the length of the estrous cycle occurred during gestation. On the contrary, a constant increment of small follicles took place throughout pregnancy.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480412
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  • 5
    Electronic Resource
    Electronic Resource
    A new sealing compound for museum jars (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 631-632 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A plastic sealing compound for museum jars is described. It has the consistancy of toothpaste and is applied in a similar manner directly to the museum jar from a tube. No catalyst or mixing is required. Moisture in the air cures the plastic in 12-24 hours. After the extruded “rope” is applied, the lid is placed on the jar and the jar set aside for the cure. After cure any excess can be trimmed with a scalpel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480416
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  • 6
    Electronic Resource
    Electronic Resource
    Masthead (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964) 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490101
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  • 7
    Electronic Resource
    Electronic Resource
    An experimental study of cerebral lesions produced by the balloon cannula method of stereoencephalotmy (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 13-21 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A method is described for making simple balloon cannulas. These may be inserted into the depths of the brain of the experimental animal and inflated, resulting in the production of a permanent destructive lesion characterized by hemorrhagic necrosis of the parenchyma, elements of the stroma being preserved peripherally. In time, a smooth, well-defined membrane delineates the oval shaped cavity resulting in a sharply punched-out lesion. A reversible lesion cannot be produced by this technique. Such lesions may have further clinical or experimental value. The local application of radioactive isotopes to specific areas of the brain under controlled situations permitting withdrawal of solutions may be possible by this method.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490103
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  • 8
    Electronic Resource
    Electronic Resource
    “Ex Vacuo” growth of adipose tissue in rats and miceThis investigation was supported by Public Health Service Research Grant A-3958 from the National Institute of Arthritis and Metabolic Diseases. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 111-114 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The excessive growth of fatty tissue around atrophic organs has been described in humans as “hypertrophy ex vacuo”. Since adipose tissue receives its blood supply from smaller branches of arteries which also supply organs or muscles, it has been suggested that increased amounts of blood could be diverted from the inactive organs to the surrounding fatty tissue and promote its growth. This theory was investigated, using rats and mice of different strains. One testis, the artery of which also supplies the epididymal fat pad, was removed, and the animals sacrificed 3-4 weeks later. Growth of the affected fat pad in both rats and mice of normal body composition was significantly reduced. Removal of the testis in adult yellow-obese mice during periods of weight gain produced a moderate but significant weight increase of the affected fat body.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480110
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  • 9
    Electronic Resource
    Electronic Resource
    Changes induced by sustained pressure in the knee joint articular cartilage of adult rabbitsSupported by U. S. Public Health Service Research Grants GM-04433-08, A-2343 (C1) and a James Hudson Brown Memorial Fund Grant of Yale University School of Medicine. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 113-133 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The right knees of rabbits were rigidly fixed with metal clamps midway between full flexion and full extension. After six dayas the knees of six were preserved while clamped. Twenty other rabbits were sacrificed after 16 days. Ten received colchicine on the eighth, eleventh and fifteenth day following clamp application. Their knees were preserved after clamp removal. The femoral and tibial articular cartilages subjected to pressure for six days were extremely compressed but viable. In knees clamped for 16 days the changes found were related to the amount of knee movement present at autopsy. Where it was small but easily detectable the cartilages were normal. Where there was no movement the cartilage was dead. Where it was only slight variable cartilage changes were found ranging from surface abradement, Matrix swelling, enlargement of lacunae and chondrocytes, increased number of cells per lacuna, and an occasional chondrocyte in mitosis, to an extensive matrix alteration resulting in the disappearance of lacunae, chondrocytes released from the confines of lacunae and interspersed among a meshwork of fine collagen fibers, and a few released chondrocytes in mitosis. The most extensive change was where the cartilage defect area was occupied by a mass of proliferating richly-cellular tissue. The knee articular cartilage changes of this experiment are compared with those occurring during pregnancy in the pubic symphyseal cartilage of mice.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490111
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  • 10
    Electronic Resource
    Electronic Resource
    Studies on the innervation of the stapedius muscle of the catSupported by the John C. and Edward Coleman Memorial Fund, Department of Otolaryngology, University of California, San Francisco Medical Center and State of Washington Initiative 171 Funds for Research in Biology and Medicine. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 157-171 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A study of nerve-muscle relations and fine innervation patterns is reported for the stapedius muscle of the cat. Gross relations of the muscle to its associated nerves and other middle ear structures are shown by illustrations. Histologic features of innervation are studied with the Bodian silver method. the thiocholine technique, and iron hematoxylin and osmic acid stains.The muscle is richly supplied by 3 to 4 facial nerve branches in which no axons are found above 8 μ and the majority are unimodally grouped at 2-4 μ. The auricular nerve of the vagus does not penetrate the muscle. Three to four distinct zone is of fasciculi are found whose muscle fibers are 14-20 μ in diameter. Each zone is supplied by primary nerves whose branches do not exhibit terminal overlap or multiple innervation of muscle fibers. Short terminal axons lead to motor and plates from all intramuscular nerve branches. Nerve branches and motor end plates are confined to the basal third of the muscle. Sensory endings are not detected within the muscle or its tendon. It is estimated that each motor neuron supplies no more than five muscle fibers but more probably three or less.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490114
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  • 11
    Electronic Resource
    Electronic Resource
    Experimental heart-block in the chick embryoStudy was made possible by NIH grant HEO-3565-06. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 217-223 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: While studying the electrocardiograms of developing hearts it was noted that an adult type ECG could not be obtained in an embryonic heart which could not be blocked with digitalis. The need to know more about heart-block was obvious. Intact embryos of 36 to 120 hours were floated on to glass plates and treated with digoxin-Tyrode solution. Before 36 ± hours no dissociation of beat could be produced. The heart just stopped. At 40 ± hours a conal block followed by a midventricular block appeared. At 42 ± hours conal and midventricular blocks were followed by the first appearance of AV block. It was intermittent. At 47 ± hours conal block jumped to an incisive AV block. Midventricular block was rare. At 72 hours conal and then AV block occurred. Combinations such as four atrial to two ventricular to one conal beat could be readily produced while blood circulated.Electrocardiograms and cinephotomicrographs were taken of 72 and 96 hour hearts. Most striking was the fact that the typical Wenckebach phenomenon of adult heart-block could be duplicated, i.e., an increase of PR interval preceding AV block followed by a shorter PR interval which again gradually increased preceding AV block. This sequence was repeated over and over. An explanation of these events is offered.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490205
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  • 12
    Electronic Resource
    Electronic Resource
    A comparison of the metalophilic reticuloendothelial cells to cells containing acid phosphatase and non-specific esterase in the lymphoid nodules of normal and stimulated rat spleensMaterials were purchased on grant no. 407 from the American Medical Association. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 269-277 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study was undertaken to determine the relationship between Marshall's metalophilic reticular cells and the cells exhibiting non-specific esterase and acid phosphatase activity in the rat spleen. Untreated and stimulated animals were used. Observations were made chiefly on the marginal metalophils of Snook. These cells showed strong acid phosphatase activity but only slight non-specific esterase activity in untreated animals. Following stimulation non-specific esterase activity increased in these cells. Within the nodules metalophilic reticular cells were always more numerous than cells with enzyme activity. Many of these metalophilic cells developed enzyme activity following stimulation. By the use of a restaining technique it was shown that all reticular cells possessing enzyme activity were also metalophilic but that the converse was not true. No mitotic activity was present in these cells.The results suggest that Marshall's metalophils are cells of the reticuloendothelial system in various stages of maturation and that, following stimulation, they may differentiate into mature phagocytic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490209
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  • 13
    Electronic Resource
    Electronic Resource
    The effect of relaxin on parathyroid histology in the mouse (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 309-312 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In the normal parathyroid gland of the mouse there is only one type of cell which is small with a large nucleus and small amount of cytoplasm. In order to investigate the effect of relaxin on parathyroid histology, mice were injected with relaxin, the degree of pubic separation was measured by the x-ray technique, and the parathyroid glands were studied histologically. After one day of relaxin injection, the pubic symphysis showed a distinct separation and in part of the parathyroid gland the cells were larger and stained lighter and pinker than the normal cells with hematoxylin, eosin, and azur II. After four days of relaxin treatment, the whole gland had changed so that all the cells were of the second type. Glands of pregnant mice near term also were composed of cells of this type. These results indicate a relationship between relaxin and the parathyroid gland.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490212
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  • 14
    Electronic Resource
    Electronic Resource
    Histochemical characteristics of mucopolysaccharides in salivary and exorbital lacrimal glands (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 333-357 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Comparison of results obtained by S35O4= autoradiography with those from histochemical staining methods and evaluation of the effect on the staining resulting from prior sialidase digestion, methylation, methylation and saponification, or sulfation, substantiates the selectivity of some procedures for sialomucin and others for sulfomucin. These two types of mucopolysaccharide may be differentiated by the high iron diamine-alcian blue or aldehyde fuchsin-alcian blue sequences or comparison between staining with the alcian blue pH 2.5-PAS sequence and staining with the alcian blue pH 1.0-PAS method. These techniques reveal that some rodent or lagomorph salivary glands form sialomucin alone, others apparently only sulfomucin, whereas a number produce both types of acid mucopolysaccharide either in different mucous cells throughout the gland or in the same cell.Differences in affinity for basic dyes, periodate reactivity, and susceptibility to elimination of basophilia by methylation or enzymatic digestion are evident among both the sulfo- and the sialomucins in different glands. After brief saponification the sialomucin in rat sublingual glands becomes sialidase digestible and gains alcohol resistant metachromasia.Several serous or seromucous glands secrete neutral mucopolysaccharides; others secrete polysaccharides containing sulfate or sialic acid groups whose affinity is masked for some but not for other basic dyes.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490304
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  • 15
    Electronic Resource
    Electronic Resource
    Localization of thalamic projection of afferents from the tongue in the catAided by grant B-3266 from the Institute of Neurological Diseases and Blindness, U.S.P.H.S. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 67-74 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Neuroanatomical nuclear configuration corresponding to the projection regions for the chorda tympani, the IXth, and the lingual nerves was studied in the cat thalamus by a combination of electrophysiological, stereotaxic, and histological techniques. Each of the three nerves innervating the tongue was dissected for stimulation in cats deeply anesthetized with Nembutal. Maps of the extent of the thalamic projection for a particular nerve were obtained by recording evoked potentials in the thalamus during the stimulation of one of these nerves. Such maps were correlated with the anatomical structures of the cat thalamus by reconstructing the recording sites from histological sections of the cat brain. It was found that the chorda tympani and the IXth nerve projection regions correspond closely to the ventromedial nuclear complex with slight encorachment on the lingual nerve projection region in the ventrobasal complex. The most medial portions of the taste nerve projection regions do not relay any tactile afferent impulses and the most lateral portion of the lingual nerve projection is not activated by impulses in the taste nerves. Therefore, it is suggested that the thalamic relay of taste is not coextensive with other lingual modalities in the cat thalamus but it has an independent representation in the ventromedial nuclear complex.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480106
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  • 16
    Electronic Resource
    Electronic Resource
    An apparatus for determination of breaking-strength of small rodent bonesDeveloped under Research Grant AM-06233, National Institute of Arthritis and Metabolic Diseases, USPHS. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 75-79 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Analysis of age changes in physical characteristics of mouse limb bones requires a sensitive, consistent and relatively simple apparatus for determination of transverse breaking strength. The developed instrument is essentially a one meter counter-balanced 4-to-1 lever with a tracked, motor-driven weight on its upper surface. At the beam's short end a loading tool impinges upward on a bone mounted in an adjacent holder; at the opposite end is a mercury switch connected to a relay halting the weight motor when fracture occurs. Bones, with proximal ends embedded in convex securing blocks of impression medium, may be positioned in a standard relationship to the holder, loading tool edge, and the balanced beam.Repetitive loading of a steel spring indicates instrument error of 1.8%. Preliminary tests with a random series of paired mouse femora show no significant difference between left and right bones. In the long-term study it will be possible to correlate physical strength with other characteristics of opposite bones.An air-gap capacitor across loading tool and bone holder and coupled to a variable frequency oscillator permits monitoring of specimen elasticity on a strip-chart recorder.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480107
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  • 17
    Electronic Resource
    Electronic Resource
    Renewal of intestinal epithelium in the freshwater turtle, Chrysemys pictaThis work was supported in part by NASA Grant Ns G-271-62 and Saint Louis University, Cancer Research Institutional Committee CRIC 33. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 427-439 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The area of new cell formation, the rate of proliferation, and the manner in which cells are lost from the intestinal epithelium in the turtle, Chrysemys picta, were studied using a cell labeling technique with tritiated thymidine and mitotic inhibiting technique with colchicine.In the intestinal epithelium of Chrysemys picta, cellular proliferation was observed to occur in the layer of cells adjacent to the basement membrane. Mitosis occurred throughout the epithelium at a fairly low rate (mitotic index 0.0016). In the upper intestine fewer labeled cells were found in the apical one-third of a villusfold than in either the mid or basal one-third. The time required to renew the intestinal epithelium, was estimated to be about eight weeks in winter turtles maintained at 20° to 24°C.Cell loss from the system appeared to be due to a randomly located movement of cells lumenward from the basement membrane.Mitotic activity in cold torpid turtles (11°C ambient temperature) appeared to be completely suppressed as shown by a lack of incorporation of tritiated thymidine and an absence of mitotic figures in the intestinal epithelium.The term villi-folds was proposed to provide a category for those animals possessing structures having characteristics both of villi and of folds as found in C. picta.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480302
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  • 18
    Electronic Resource
    Electronic Resource
    Measurement of hepatic parenchymal cell and nuclear volume in different classes of vertebrates (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 499-501 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The volumes of parenchymal cells and their nuclei in liver were calculated in white rats, Columba livia (rock pigeon), Calotes versicolor (garden lizard) and Bufo melanostictus (toad); from their optical area and cell thickness. The area was measured from camera lucida drawings. The largest cellular and nuclear volume was observed in rats and smallest in pigeons. The cell volume in toads was similar to that found in rats but they had smaller nuclei. The cellular and nuclear volumes in lizards were smaller than in toads; and in pigeons smaller than lizards. The significant difference, in both cellular and nuclear volumes that has been observed in different classes of vertebrate, cannot be correlated with the evolutionary changes.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480307
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  • 19
    Electronic Resource
    Electronic Resource
    Variations in the anatomic origin of the nutrient artery of the canine femurSupported by National Institutes of Health (USPHS) grant (no. H 7102). (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 547-552 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In the literature the nutrient artery to the diaphysis of the canine femur has been described as arising from the medial circumflex femoral artery which is a branch of the deep femoral artery. However in 19% to 100 canine hind extremities dissected after injection with colored media, the femoral nutrient artery arose from a large muscular branch (the proximal posterior femoral) of the superficial femoral artery. In 17% of 42 dogs one femur only was supplied by this variant. In three additional femurs other variations occurred.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480404
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  • 20
    Electronic Resource
    Electronic Resource
    A histochemical and histophysical survey of the effects of different fixatives on the thyroid gland of rats (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 573-579 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Fixation of the thyroid gland with formaldehyde-ethanol-acetic acid retains a larger proportion of colloid constituents than aqueous formaldehyde.Comparative histochemistry has revealed a larger proportion of protein, arginine, cabohydrates and iodinated material.The heterogeneous staining pattern was not observed after aqueous formaldehyde fixation.The intracellular globules and the early iodinated fraction of the colloid were similarly stained.Intracellular globules were not observed in aqueous formaldehyde-fixed tissues.Only the more slowly labeled fraction of the colloid (large follicles), was stained by toluidine blue and also by bromphenol blue without mercury, indicative of basic proteins.
    Additional Material: 8 Ill.
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    Ectopic glomeruli in the human and animal kidney (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 1-11 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ectopic glomeruli and proximal convoluted tubules were found in the kidneys of the rat, cat, dog, rabbit and ferret and in the human full-term fetus. They lay in the connective tissue around the main intrarenal vessels and deep to the pelvic mucosa. Their afferent arterioles were long and gave branches to the pelvic mucosal plexus, while their efferents supplied the pelvic mucosa and the medulla, or one or the other of these tissues. In the rabbit the ectopic glomeruli often produced small cysts in the pelvic septum. Degenerating ectopic glomeruli were occasionally found and in the dog the majority of them showed this change. In the adult human kidney, aglomerular arteries supplied both the pelvic mucosa and the medulla and it is suggested that such arteries are the result of degeneration of ectopic glomeruli.
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  • 22
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    Effects of maternal folic acid deficiency on cytologic phenomena in the rat embryoAided by a grant from the National Foundation and N.I.H. grant HD 00109-01. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 49-55 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A purified diet lacking folic acid and containing 20 mg% of the antimetabolite, 9-methyl pteroylglutamic (folic) acid was fed to female Long-Evans rats during days eight and nine of pregnancy. Embryos were removed at autopsy on the tenth day of gestation for study and comparison with embryos from normal control pregnancies.Analysis of mitotic counts revealed that 18.6% of the cells in control embryos were in mitosis in contrast to only 5.7% in PGA-deficient embryos. A disproportionate reduction in anaphase and telophase stages was observed in conjunction with an increased percentage of cell at metaphase. Concomitantly with these mitotic changes a marked reduction in histochemically demonstrable RNA and in numbers of ribosomes as revealed by electron microscopy was observed.
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    A possible mechanism responsible for the melanocyte distribution of the perineal pigment spot of the mouseSupported by U.S.P.H.S. grants C-592 and 2G-329 to Brown University. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 59-65 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The perineal pigment spot of the C57 Black mouse was examined macro- and microscopically in animals ranging in age from 14 days post-fertilization to 28 days post-parturition. Dendritic pigment-containing cells first become evident in the dermis of the area on the sixteenth day post-fertilization. Throughout later stages of development, these pigmented cells continue to be restricted to the dermis of this area. Since the dopa treatment reveals the presence of a melanin synthesizing system within these cells, they are true melanocytes which have become restricted to this layer of the integument.Histological examination reveals a population of melanocytes in the epidermis and/or hair follicles also. These are rarely found over the center of the area but are seen in increasing numbers laterally from the ventral midline. In contrast, dermal melanocytes are heavily concentrated near the ventral midline but decrease in numbers laterally. There are, therefore, two opposing but complementary gradients of melanocytes in the integument of the pigment spot. This suggests the possibility that a precocious differentiation of the basement membrane in this area during embryonic development inhibits the passage of melanoblasts into the epidermis thereby causing them to be restricted to the dermis.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480105
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  • 24
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    Electron microscopic studies on the red pulp of the rabbit spleenA preliminary report on this investigation was presented at Washington, D.C. in April, 1963, at the seventy-sixth annual session of the American Association of Anatomists (Roberts, '63). (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 81-101 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Electron microscopic studies reveal that the red pulp of the rabbit spleen is composed of reticular cells, reticulum and elements of the blood circulating through it. The three types of reticular cells described follow no definite pattern as to types of spaces they line and are not always adjacent to a basement membrane. Similar or dissimilar cells may line a basement membrane on the same or opposing sides. The entire red pulp area is intercommunicating through pores and junctions of the several spaces and in that area in which no basement membrane exists, the cytoplasmic projections of the reticular cells form a meshwork of spaces. Terminal arterioles are seen to end in collapsed type channels with a change from endothelium to Type I reticular cells. These rapidly join dilated areas. The reticular network of the spleen appears as four types: homogeneous, fibrillar, a combination of these, and reticular cells only. Isolated cilia are found in the reticular cell cytoplasm and are shown to be associated with a basal body and a centriole. The investigation supported the hypothesis that the red pulp of the spleen in the adult rabbit is a functionally dynamic area constantly changing its histological structure, both regarding cells and state of the vascular channels.
    Additional Material: 16 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480108
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    Masthead (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964) 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480201
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  • 26
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    Observations on the ultimobranchial body in Rana pipiens (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 219-229 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The ultimobranchial body was investigated in 63 specimens of Rana pipiens. The morphology is described for “typical” (unifollicular) glands and those found in animals in poor physiological (“stressed”) condition. The typical follicular epithelium is of a mixed pseudostratified type and includes “elongate” cells which extend from the basement membrane to the free surface. These contain elongated nuclei, prominent terminal lipid droplets and “deltoid bodies” which are triangular, homogeneously staining structures apical or basal to the nucleus. “Isometric” cells do not extend to the basement membrane. They posses intensely staining nuclei, few lipid droplets and no deltoid bodies. The stressed gland is multifollicular and degenerate. Mitochondria, lipid droplets, deltoid bodies and glycogen have been identified and are located in specific areas of the follicular cells. The secretory products within the lumina of the glands have tentatively been shown to contain acid mucopolysaccharides, carbohydrate-protein complexes, mucoproteins, lipid droplets and lipid complexes. These secretions may either represent possible precursors to future secretions or a retention of secretions produced during metamorphosis. The ultimobranchial body has shown no indication of degeneration in the adult.The ultimobranchial body in typical Rana is an active secretory gland which shows no indication of degeneration in normal adult anurans. Furthermore, it responds to fluctuations in environmental conditions as illustrated by its altered structure and varied types of secretion when stressed.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480212
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    Microradiography of the pulmonary microcirculationThis investigation was supported by Grant DE-01785-01, Grant HE-04846-04 CV and Grant HE-06780-02 CV. U. S. Public Health Service. The National Institute of Health. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 459-465 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Conventional radiographs of lungs of calves which had been injected post mortem with barium sulphate could not be used to demonstrate vessels smaller than 50 μ in diameter. To overcome this difficulty, frozen sections 50-150 μ thick were floated on to high resolution photographic plates and contact microradiographs made using soft radiation. The resultant microradiogram was then viewed and photographed with the light microscope. It was possible to visualize the smaller arterioles and the capillary networks around the alveoli. The technique is simple and gives reproducible results.
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    URL: http://dx.doi.org/10.1002/ar.1091480304
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    Glycogen synthetase in the rabbit tongue and uterusThis investigation was supported by the National Science Foundation, (NSF-G-21377). (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 503-505 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: UDPG-glycogen synthetase was studied in the uterus of ovariectomized and ovariectomized-hormone treated rabbits and in the tongue. Following the biochemical technic of Leloir and Goldenberg it was not possible to demonstrate the enzyme in the uterus of the ovariectomized or ovariectomized treated animals. However, in the tongue the enzyme was present. The data from this study along with previous histochemical studies indicates that the glycogen in the uterine muscle is not synthesized through the UPDG pathway, but is synthesized from G-1-P by the action of phosphorylase. Since UDPG-glycogen synthetase can be demonstrated in the tongue a difference seems to exist in glycogen synthesis between the smooth muscle of the uterus and skeletal muscle of the tongue.
    Additional Material: 1 Tab.
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    Masthead (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964) 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091480101
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    Anatomy of the A-V node of the dogSupported in part by grants from the U. S. Public Health Service (H-7108) and the Michigan Heart Association. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 15-27 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The A-V node of the dog is composed of closely interwoven fibers which frequently connect with each other within a sparse collagen framework. Fibers from the interatrial septum enter the posterior half of the node along its superior and posterior margins, while the anterior half of the node is isolated from such connections. In addition there are fibers from the interatrial septum which bypass these marginal atrionodal junctions and instead enter the convex surface of the node, which lies beneath the right atrial endocardium. These bypassing fibers circumvent most of the interweaving fibers within the A-V node. At the posterior margin of the node, lying between it and the coronary sinus, there are ganglia and nerves, with the nerve fibers extending anteriorly through the A-V node into the A-V bundle. The only major anatomic difference between the human and canine A-V nodes is their arterial blood supply, that of man being derived from one source originating from the right coronary artery and that of the dog being from two sources, both of which originate from the left coronary artery.
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    URL: http://dx.doi.org/10.1002/ar.1091480103
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    Evocation of regrowth phenomena in anuran limbs by electrical stimulation of the nerve supplyThis investigation was supported by Public Health Service Research Grants GM 05820 from the National Institute of General Medical Sciences and NB 03210 from the National Institute of Neurological Diseases and Blindness. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 441-457 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Experiments reveal that growth reactions may be evoked in amputated forelimbs of fully adult Rana pipiens and R. catesbiana by electrical stimulation of the normal limb nerve supply. The evoked growths were generally small cones, 5-10 mm in length; none developed into limbs of normal size and morphology, but some formed digits and cartilage and developed striated muscle. The combined influences of trauma, effected by salt treatment, and electrical stimulation of the nerve produced more growths than trauma or stimulation alone.
    Additional Material: 27 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480303
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    Macrophages in post-secretory mammary involution in miceThis investigation was supported (in whole) by Public Health Service Grants A-2693 (M. and N.) and HE-07318 from the Natinal Heart Institute. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 99-111 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Vital staining by trypan blue was used to demonstrate macrophages within involuting (post-secretory), lactating and resting mammae of mice. Involution was produced by removal of the nursing young on the eighth day post-partum when maximal lactation was present. The number of macrophages in involutin mammae was not significantly greater than that found in the rsting glands of mice receiving comparable injections of dye. Macrophages (coarse, granular accmulations of trypan blue in cytoplasm) in involutin mammae were congregated around and within atrophic alveoli and small ducts, while in lactating and resting mammae they were located primarily in the areolar stroma. Plasma cells, lymphocytes and neutrophils were increased during involution, but the limited leucocytic response did not indicate that a significant inflammatory reaction was active in the process of involution. Difuse parenchymal staining, indicating cellular injury or death, was limited to the epithelium of necroptic ducts and alveoli of involuting glands. Granular deposits of dye, as in macrophages or renal tubular epitelium, were not seen in the resting, lacating or involuting mammary parenchyma.
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    Masthead (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964) 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490201
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    Lymphocyte formation in the thymus of the embryonic chickSupported by research grants HE-04061-05 (HEM) and 1 SO1 FR-05109-01 from the National Institutes of Health, Bethesda, Maryland. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 191-215 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Embryonic thymus provides a distinct advantage over the definitive thymus because the earliest formation of lymphocyte and lymphocytic precursors can be observed in a relatively simple and uncomplicated situation. Special cytological techniques combined with light, phase, and electron microscopy have been performed in this investigation involving over 150 chick embryos between 5 and 18 days of embryonic development.Sequential cytological changes in the development of the thymus into an active lymphocytopoietic organ indicate that lymphoblasts develop by the gradual proliferation and transformation of “undifferentiated” epithelial cells comprising the primordial thymus. Lymphoblastic transformation begins on the seventh day of embryonic development in the chick and is characterized by increased cytoplasmic and nucleolar basophilia and chromatin condensation. “Undifferentiated” epithelial cells undergo two distinct lines of differentiation between the seventh and tenth days: into lymphoblasts and into stellate reticular-epithelial cells which constitute the organ parenchyma. All stages of lymphocytic maturation may be observed by 10-11 days as the thymus assumes a predominately lymphocytic character. Absence of lymphocytes or lymphocytic precursors in the connective tissue surrounding the embryonic thymus before and during the period of initial lymphoblastic transformation; presence of a continuous basement membrane surrounding the developing thymus; and absence of cells passing through this membrane during this phase of development indicate that the lymphocytic elements appearing in the embryonic thymus parenchyma are of epithelial rather than mesenchymal derivation. Although a contribution of mesenchymal elements to the lymphocytic population via vascular invasion and lobular formation in later stages of thymic development is unlikely, this question cannot be answered at this time. In spite of functional immunological distinctions between the lymphocytes of the chick thymus and bursa of Fabricius, the similarity of origin of the lymphocytic elements of these lympho-epithelial organs is apparent.
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    The ultrastructure of megakaryocytes and blood platelets in the rat spleenSupported in part by research grants from the National Institutes of Health A-131 (C9) and from the Upjohn Company. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 251-267 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The cytoplasm of the megakaryocyte in the rat spleen possesses three zones, the perinuclear, intermediate and marginal. The perinuclear zone is characterized by the presence of Golgi apparatus, ribosomes, endoplasmic reticulum, and mitochondria. These organelles are found also in the more voluminous intermediate zone which in addition exhibits platelet granules and an extensive development of vesicles from smooth-surfaced endoplasmic reticulum to form demarcation membranes by coalescence. The marginal zone is almost devoid of the organelles and inclusions present elsewhere. Shedding of platelets appears to occur by extension of a paired demarcation membrane from the intermediate zone to the cell membrane and subsequent separation of its lamellae so that all of the essential organelles and inclusions of the intermediate zone may be included within the platelet. In addition, platelets contain vesicles which are probably pinocytotic in nature. Platelets are sometimes engulfed by the cytoplasm of phagocytic cells.
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    URL: http://dx.doi.org/10.1002/ar.1091490208
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  • 36
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    Masthead (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964) 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490301
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    Composition of trabecular and cortical bonePortion of the work was done at the U.S. Naval Radiological Defense Laboratory, San Francisco, California, supported by the U.S.N. Bureau of Medicine and Surgery Task MR 005.08-1200, Subtask I. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 325-331 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A technique was devised for obtaining marrow-free trabecular bone so that the trabecular and cortical bone composition of dog, steer, monkey and man could be studied. Vertebral body was cut in the frontal plane into slices 2 mm thick with an electric band saw. The cortical bone encrircling each slice was trimmed off with a cleaver, leaving intact a lacy slice of trabecular bone. The marrow substance was washed away by fine and powerful jets of tap water obtained from an adjustable nozzle. Marrow washing was discontinued when no trace of red color was visible on holding the slice in front of a strong light source.The quantities of water, volatile inorganic, organic and ash fractions in cortical bone was alike for all species. Likewise, the trabecular bone fractions of each was quantitatively similar. In general, density and amount of ash in cortical bone was higher than that in trabecular bone. The water and ash:organic ratio were higher in trabecular than in cortical bones.Ratios of trabecular to cortical ash for the bones in an entire dog skeleton were also determined. Based on this, volume or mass of the various bone fraction may be estimated when the weight of the ash for any particular bone is known.
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    An improved method for evaluating osteogenesis in vitroSupported in part by a grant from the Squibb Institute for Medical Research and by the United States Public Health Service grant no. GPD-16, 196. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 57-66 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A simple, rapid method is presented which permits qualitative evaluation of osteogenesis in tissue culture. Eleven-day embryonic chick tibiae, with distal and proximal condyles removed, were grown in organ culture for two weeks. Explants demonstrated subperiosteal osteogenesis, bridging of fracture defects, and formation of bone, de novo, over the cut cartilaginous end surfaces of explants.The method presented herein has several advantages over those previously described and may be adopted for an in vitro assay of materials to determine direct effects on osteogenesis. Large quantities of explants can be prepared easily and cultured to yield consistantly abundant quantities of osteoid. Bone which is formed over ends of anlage is particularly significant by virtue of its position. New bone formed elsewhere in explants, with the possible exception of the fracture sites, however, is difficult to distinguish from bone present before onset of cultivation. Further more, osteogenesis which occurs over the cut cartilaginous ends after a week of culture, probably results from favorable environmental conditions in vitro and not from cellular activity “preprogrammed” in ovo.In addition to osteogenesis, alteration of cartilage cells and matrix were observed in this system. Chondrocytes in the cut ends of the anlagen became spheroidal and resembled osteoblasts. Bone formation, however, was not observed about these cells. In and about lacunae of degenerating chondrocytes at the ends of the anlagen, collagen fibers appeared.
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    URL: http://dx.doi.org/10.1002/ar.1091490107
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    Effect of transplacental mitotic inhibitors on the fetal hamster eyeSupported by U. S. Public Health Research grant GM 10210-01. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 129-137 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Congenital malformations of the hamster eye, consisting of microphthalmia and anophthalmia have been noted consistently in the offspring of pregnant hamsters treated with intravenous injections of colchicine, Vinacaleukoblastine (VLB) and Vincristine (VCR) on the eighth day of gestation. In an attempt to compare the mitotic-arresting activity of these three compounds on the lens and retina of the fetal hamster eye, various concentrations of the drugs were injected into pregnant hamsters on the fourteenth day of gestation and the fetuses recovered after three hours. Mitotic counts were done on comparable sections of lens and retinas of the fetuses. Colchicine has the most marked mitosis-inhibiting activity of these three drugs. The most effective mitosis-inhibiting dosage of colchicine also correlates with its most effective teratogenic dose. VLB and VCR do not inhibit mitosis in the fetal hamster eye as markedly as colchicine and their most effective mitosis-inhibiting dosages are equal to or above levels which cause a 95-100% embryonic mortality. It is possible that some common biological mechanism other than inhibition of mitosis may be responsible for the similar teratogenic activity of these compounds. The natural resistance of the golden hamster to colchicine does not appear to be manifest in the developing embryos in utero.
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    URL: http://dx.doi.org/10.1002/ar.1091480203
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    Anatomic considerations for regional intimal changes in the coronary arteriesThis investigation was supported in part by Public Health Service Research grant HE-04989, from the National Institutes of Health. (Dog) (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 161-169 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Intimal proliferation in dog coronary arteries occurred in the vessel having the greatest range of motion. Within an involved segment of the artery, intimal proliferation could be related to the anatomy of the muscle bundles. Arterial muscle bundles originate from the adventitia, spiral around the artery and insert distally into the adventitia. The adventitia and the internal elastic lamina course along the long axis of the artery and are connected by elastin-collagen fibers. Intimal thickening developed under the muscle insertion sites in regions where the adventitia was apparently placed under tension. In these regions, the net force of a muscle bundle contraction increases and shearing would occur between a muscle bundle at its insertion site and the remaining bundles gliding past it. This local shear force would then be transmitted to the internal elastic lamina through the elastin-collagen fibers which connect it to the adventitia. Deformation and apparent injury of the internal elastica would follow and cause a fibrous tissue response. In the smaller arteries and arterioles, intimal proliferation occurred most prominently in the vessels supplying a mobile structure, i.e., anterior papillary muscle of the left ventricle.
    Additional Material: 17 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480206
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    The chondrification of the human iliumThis work was supported by a grant from the Canadian Arthritis and Rheumatism Society. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 197-202 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This report on the early human ilium is based on the Streeter collection, Carnegie Institution of Washington, Department of Embryology, Baltimore. The five phases in chondrogenesis, described by Streeter for the humerus ('49) and the horizons (Streeter, '42) are used in the description of the changes observed in the ilium. From horizon XV (7-8 mm, 30-32 days) to horizon XVIII (14-16 mm, 36-38 days) component cells of the ilium are mesoblasts. In horizon XIX (17-20 mm, 38-40 days) young cartilage cells have appeared. Both phase 1 and phase 2 cells appear in horizon XX (21-23 mm, 40-42 days), the former characterized mainly by the first appearance of intercellular material, the latter by their slender shape and arrangement in tiers. Phase 3 cartilage cells, cuboidal with many vacuoles, appear in horizon XXI (22-24 mm, 42-44 days). Increasing vacuolization of the cytoplasm of cells is noted throughout horizons XXII and XXIII until, in horizon XXIII (28-30 mm, 46-48 days) total disintegration of cells, a feature of phase 5, is evident. Thus the phases of cartilage differentiation described for the humerus are present also in the ilium.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/ar.1091480209
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  • 42
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    An electron microscope study of the rat endometrium during delayed implantationSupported by National Science Foundation grant G-21829. During the course of this investigation, the senior author was a National Science Foundation Graduate Fellow. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 148 (1964), S. 177-195 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The luminal and glandular epithelia of the rat uterus during delayed implantation have been studied with the electron microscope. The tall columnar cells of the luminal epithelium are characterized by a distinct zonation of organelles. On the free surface there are short microvilli and occasional cytoplasmic extrusions, with terminal bars joining adjacent cells at their apical margins. Beneath the free surface are numerous pinocytotic vesicles and mitochondria. Above the nucleus are a prominent Golgi apparatus with large dilated vacuoles, and numerous dense inclusion bodies. Large clusters of lipid droplets and aggregations of mitochondria occupy the basal zone of the cell.The apical portion of the gland cell has fewer pinocytotic vesicles and the Golgi is smaller than in the luminal epithelial cells. Dense bodies are numerous above the nucleus. The basal portion of the gland cell is devoid of lipid, but there are often one or more enlarged mitochondria. Although a dense PAS+ substance fills the lumina of the glands, there is no obvious evidence of secretory activity in the glands during delay.The relationships of the epithelia to the environment of the blastocysts during delay is discussed.
    Additional Material: 7 Ill.
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  • 43
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    2- und 3-Oxo-tetrahydro-carbazol aus 2- bzw. 3-Hydroxy-carbazolHerrn Professor Dr. Fritz Kröhnke zum 60. Geburtstag (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 127-134 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Reduktion mit Lithium und Äthanol in flüssigem Ammoniak werden 2- und 3-Methoxy-carbazol zu 1.4-Dihydro-Derivaten reduziert, die als Enoläther nach Spaltung mit Säuren in 2- bzw. 3-Oxo-tetrahydrocarbazol übergehen. Die Eigenschaften der vier isomeren Oxotetrahydrocarbazole werden an Hand neuer Reaktionen des 1- und 4-Oxo-tetrahydrocarbazols verglichen. N-Methyl-2-methoxy-carbazol liefert bei der Metallamin-Reduktion die 1.4.5.8-Tetrahydro-Verbindung, die von Salzsäure zu 2-Oxo-1.2.3.4.5.8-hexahydro-carbazol hydrolysiert wird.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646710119
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  • 44
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    Masthead (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964) 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646720101
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  • 45
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    Borverbindungen, VIIVI. Mitteilung: R. Köster und K. Iwasaki, Advances Chemistry Series 42, 148 (1964) vgl. Boron-Nitrogen-Symposium Durham N. C./U.S.A., April 1963, Preprints of Papers S. 123.. Organische Borverbindungen durch Hydroborierung olefinischer Kohlenwasserstoffe mit Alkyldiboranen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 1-34 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird über die Hydroborierung olefinischer Kohlenwasserstoffe (Alkene, Cycloalkene, Diene, Cyclodiene, Cyclotriene, halogenierte Olefine) mit verschiedenen Alkyldiboranen (z. B. “Tetra-[alkyl-(1)]-diborane”, “Tetra-[sek.-alkyl]-diborane”, Bis-borolane) berichtet2,3). Dabei wird auch die relative Geschwindigkeit der Anlagerung von Tetra-[propyl-(1)]-diboran bzw. dessen Additionsverbindung mit Triäthylamin an verschiedenartige C=C-Bindungen gemessen.-Eine präparative Methode zur Herstellung definierter bororganischer Verbindungen (z. B. Tri-[alkyl-(1)]-borane, Trialkenylborane, B-Alkyl-boracyclane, halogenierte Trialkylborane) wird beschrieben.
    Additional Material: 4 Ill.
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  • 46
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    Raman- und Infrarot-Spektren einiger definiert an der Doppelbindung deuterierter OlefineHerrn Prof. Dr. K. Ziegler zum 65. Geburtstag in Dankbarkeit und Verehrung gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 44-54 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wurden die Raman-Spektren von 1- und 2-Deutero-hexen-(1), 1.2-Dideutero-hexen-(1), 3-Deutero-hexen-(3-cis), 3.4-Dideutero-hexen-(3-cis) und - zum Vergleich - von 1.1-Dideutero-hexan photoelektrisch registriert. Die IR-Spektren wurden mit einem Gittergerät neu aufgenommen, wobei vor allem im Gebiet über 2000 cm-1 eine viel bessere Auflösung erzielt werden konnte, und durch Aufnahmen mit einem CsBr-Prisma im Gebiet von 500-280 cm-1 ergänzt. Eine verbesserte Zuordnung der CH- und CD-Valenzschwingungen wird angegeben. Beim 3.4-Dideutero-hexen-(3-cis) wird die bisher in Frage gestellte Kopplung der beiden CD-Valenzschwingungen über die Doppelbindung hinweg nachgewiesen. Die Zuordnung der Schwingungen der olefinischen Gruppierung wird weiter vervollständigt.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646720104
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  • 47
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    Über organische Schwefelradikale, III.II. Mitteilung: U. Schmidt und A. Müller, Angew. Chem. 75, 299 (1963). Organische Schwefel-Radikalionen (Sulfiniumsalze)Herrn Prof. Dr. Dr. h. c. Clemens Schöpf zum 65. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 78-90 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch ESR-Messung werden in den mit K2S2O8 oxydierten Lösungen von Diarylthioäthern in konz. Schwefelsäure beständige Sulfinium-Radikalionen Ar-S⊕-Ar nachgewiesen. Diese bilden sich auch aus den entsprechenden Sulfoxyden in Schwefelsäure oder Polyphosphorsäure ohne zusätzliches Oxydationsmittel. Stabiler sind die Radikalionen aus Tetraphenylthiophenen und p-Phenylendimercapto-diaryläthern. Substitution der Phenyle durch Elektronendonatoren stabilisiert die Radikale. Bei der Oxydation der Thioäther mit Halogen in SnCl4 fallen die stabilen, aber sehr feuchtigkeitsempfindlichen “Sulfinium”-hexachlorostannate aus, die sich mit Anisol zu den entsprechenden Sulfoniumsalzen umsetzen. Die oft beschriebene Bildung von Sulfoniumsalzen aus Sulfoxyden und Phenolen in starken Säuren dürfte in vielen Fällen über “Sulfiniumsalze” verlaufen.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646720107
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  • 48
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    Derivate des o-Diphenochinons (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 92-97 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung von o-Diphenochinon-Derivaten wird beschrieben.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646710113
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  • 49
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    Auf das Zentralnervensystem wirkende Substanzen, XXXIII. 3-Hydroxymethyl-3-phenyl-azetidin und Derivate (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 97-106 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung des 3-Hydroxymethyl-3-phenyl-azetidins (II) durch LiAlH4-Reduktion von 3-Hydroxymethyl-3-phenyl-azetidinon-(2) (I) wird beschrieben. Zahlreiche Derivate (N- und O-Acyl-, N-Nitroso- und N-Amino-Derivate; Mannich-Basen) von II werden hergestellt. Die “alkylierende Reduktion” sowie die Alkylierung durch Alkylhalogenide gelingt nicht. Durch Einwirkung von Säureanhydriden auf die N-Alkyl-Derivate tritt eine unerwartete Ringspaltung ein, wobei in guter Ausbeute 2.2-disubstituierte 3-Alkyl-amino-propanole gebildet werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646710114
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  • 50
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    Synthese und Reaktionen von 1.3.4-Oxathiazolin-3-dioxydenMeinem hochverehrten Lehrer, Herrn Professor Dr. Fritz Kröhnke, zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 135-146 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die aus Chlormethansulfonamid (I) und aromatischen oder heterocyclischen Säurechloriden leicht zugänglichen 5-substituierten 1.3.4-Oxathiazolin-3-dioxyde (II) bilden mit tertiären Aminen, auch mit Triphenylphosphin, salzartige Addukte. Primäre und sekundäre Amine sowie Hydrazine reagieren mit I zu Amidinen bzw. Hydrazidinen. Die Reaktionsmechanismen werden diskutiert.
    Additional Material: 2 Tab.
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    URL: http://dx.doi.org/10.1002/jlac.19646710120
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  • 51
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    Synthese von 4-Hydroxy-dihydrogalegin und verwandten Guanidinderivaten (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 154-159 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird die Synthese von 4-Hydroxy-3-methyl-butylguanidin (4-Hydroxy-dihydrogalegin, IV) aus 4-Hydroxy-3-methyl-buten-(2)-säure (I) über 4-Acetoxy-3-methyl-buten-(2)-säureamid (II) und 4-Hydroxy-3-methyl-butylamin (III) beschrieben. In analoger Weise ließen sich 3-Methyl-buten-(2)-yl-guanidin (Galegin, VIII) sowie 3-Hydroxy-3-methyl-butylguanidin (3-Hydroxy-dihydrogalegin, XI) neu darstellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646710122
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  • 52
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    Cytostatisch wirkende Sulfoniumsalze, III.Herrn Prof. Dr. Hans Brockmann zum 60. Geburtstag gewidmet. Kinetische und Polarographische Untersuchungen zur Klärung ihres Wirkungs-ChemismusII. Mitteilung: A. Lüttringhaus und H. Machatzke, Arzneimittel-Forsch. 13, 366 (1963). (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 671 (1964), S. 165-196 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Reaktionen cytostatisch aktiver Sulfoniumsalze mit Hydroxyl- und Mercaptid-lonen werden unter physiologischen pH-Bedingungen untersucht. Die Geschwindigkeiten dieser Umsetzungen zeigen eindeutige Beziehungen zu den polarographischen Halbstufenpotentialen (E1/2) der Sulfonium-Kationen. In den statischen E1/2-Werten kommt die dynamische “Reaktivität” von Sulfoniumsalzen gut zum Ausdruck. Die Reaktionsbereitschaft gegenüber SH-Gruppen wiederum zeigt Parallelen zur cytostatischen Aktivität und bestärkt die Theorie, daß wenigstens eines der Wirkungsprinzipien der Cytostatica auch der Sulfoniumsalz-Reihe in einer Blockierung biologisch wichtiger SH-Gruppen zu sehen ist.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646710124
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    Organozinnverbindungen, V. Über DiäthylzinnHerrn Professor Dr., Dr. E. h., Dr. h. c., Dr. h. c. Karl Ziegler zum 65. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 34-43 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Kristallines, nonameres Diäthylzinn entsteht fast quantitativ aus Diäthylzinndihydrid unter H2-Austritt, wobei die Molekülverbindung (C2H5)2SnCl2·2 Pyridin als Katalysator wirkt. Es ist gelb und sehr luftempfindlich. Nach allen vorliegenden Befunden muß eine Ringstruktur (Octadecaäthylcyclononastannan) angenommen werden. Unter anderen Bedingungen wurden hexamere oder heptamere Modifikationen erhalten. Eigenschaften und Reaktionen werden, auch im Hinblick auf frühere Literaturangaben über “Diäthylzinn”, kritisch diskutiert.
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    URL: http://dx.doi.org/10.1002/jlac.19646720103
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  • 54
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    Die Fragmentierungsreaktion als Konkurrenzreaktion zur Hofmann-Eliminierung quartärer Pyrrolidiniumsalze mit Phenyl-lithium (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 92-95 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Auch quartäre Pyrrolidiniumsalze, welche für eine α'.β-Eliminierung geeignete β-Wasserstoffatome besitzen, reagieren mit Phenyl-lithium unter Fragmentierung. Daneben findet eine α'.β-Eliminierung statt. Der Anteil der beiden Reaktionen an der Gesamtreaktion wurde an N-Methyl-N-äthyl-pyrrolidiniumjodid mit Hilfe von 14C-Markierung untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730112
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  • 55
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    Über Phenthiazone, IX.VIII. Mitteilung: C. BODEA, M. RAILEANU und I. SILBERG, An. stiint. Univ. „Al. I. Cuza“ Iasi, Sect. I 6, 1023 (1960) [C. A. 59, 11478 (1963)]. Hochhalogenierte Phenthiazine und Phenthiazone (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 113-120 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Darstellung hochchlorierter und hochbromierter Derivate des Phenthiazins, Phenthiazin-5-oxyds und Phenthiazin-5-dioxyds wird beschrieben. Eine größere Anzahl von Halogenatomen im heterocyclischen System erschwert oder verhindert sogar die Umwandlung in Phenthiazone mit Dichromat in Eisessig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730115
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  • 56
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    Reaktionen mit Diazo-carbonylverbindungen, VIII. Dioxole aus Diazoketonen und aromatischen Aldehyden (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 120-123 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Thermolyse von p-Methyl- und p-Methoxy-benzoyl-diazomethan führt in Gegenwart von aromatischen Aldehyden unter Stickstoffeliminierung zu substituierten Dioxolen.
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    URL: http://dx.doi.org/10.1002/jlac.19646730116
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  • 57
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    Reaktionen mit cyclischen Enaminen, I. Umsetzung von Cycloalken-aminen mit Phenyl-isocyanat bzw. Phenyl-senföl (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 132-136 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cyclische Enamine reagieren mit Phenyl-isocyanat bzw.-isothiocyanat zu β-Amino-cycloalken-carbonsäure- bzw. thiocarbonsäureniliden, die sich zu Cycloalkanon-(2)-carbonsäure- bzw. -thiocarbonsäureaniliden verseifen lassen. Letztere werden mit konz. Schwefelsäure zu 3.4-Cycloalkyl-carbostyrilen bzw. -2-mercapto-chinolinen cyclisiert.
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    URL: http://dx.doi.org/10.1002/jlac.19646730119
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  • 58
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    Pyrimidyl-(4)-Derivate von Aminens und Aminosäuren (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 153-165 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2.4(6)-Dichlor-pyrimidin und 2.4(6)-Dichlor-5-methyl-pyrimidin reagieren mit aliphatischen Aminen, Äthylendiamin und L-Lysin unter Aminolyse des 4-ständigen Chloratoms. Durch Hydrogenolyse erhält man NNH2-Pyrimidyl-(4)-Derivate, durch Umsetzung mit Natriumalkoholat 2-Äthoxy-pyrimidine, die zu den 2-Hydroxy-Verbindungen hydrolysiert werden können. 2-Hydroxy-5-methyl-4-alkylamino-pyrimidine werden ferner aus 2-Hydroxy-5-methyl-4-alkylamino-pyrimidin mit Aminen erhalten. 2-Hydroxy-5-methyl-4-methyl-mercapto-pyrimidin mit Aminen erhalten. 2-Hydroxy-4-alkylaminopyrimidine werden aus 2-Methylmercapto-4-chlor-pyrimidin durch Aminolyse und anschließende Säurehydrolyse synthetisiert. Die Darstellung von β-[Uracil-yl-(4)]-äthylamin und die Umsetzung mit 6-Chlor-purin wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730122
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  • 59
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    Über Peptidsynthesen, XVIXV. Mitteilung: E. SCHRÖDER, Liebigs Ann. Chem. 670, 127 (1963).. Synthese von Orn-Kallidin und Kallidin (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 176-186 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Synthese des Decapeptids L-Ornithyl-L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginin (Orn1-Kallidin) wird beschrieben. Die biologische Aktivität dieser Verbindung wird mit derjenigen von Kallidin, das auf zwei Wegen hergestellt wurde, verglichen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730125
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  • 60
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    Über Peptidsynthesen, XVIII.XVII. Mitteilung: E. SCHRÖDER, Liebigs Ann. Chem. 673, 186 (1964), voranstehend. Darstellung und Reaktionen von N-substituierten L-Glutaminsäurederivaten (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 196-207 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus tert.-Butyloxycarbonyl-, p-Methoxycarbobenzoxy- und p-Nitrocarbobenzoxy-L-glutaminsäure werden die entsprechenden N-Acyl-L-glutaminsäureanhydride und daraus die N-Acyl-L-pyroglutaminsäuren hergestellt. Unter Verwendung der genannten Aminoschutzgruppen sowie der Phthalylgruppe werden verschiedene, für die Peptidsynthese nützliche, selektiv substituierte Glutaminsäurederivate synthetisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730127
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    Über Peptidsynthesen, XIX.XVIII. Mitteilung: E. SCHRÖDER und E. KLIEGER, Liebigs Ann. Chem. 673, 196 (1964), voranstehend. N-substituierte Derivate des Asparagins und des Asparaginsäure-β-tert.-butylesters (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 208-220 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Carbobenzoxy-tert.-Butyloxycarbonyl-, p-Methoxycarbobenzoxy-und Phthalyl-L-asparaginsäure-β-tert.-butylester sowie tert.-Butyloxycarbonyl-, p-Methoxy6carbobenzoxy-und Phthalyl-L-asparagin wurden, zum Teil in Form ihrer p-Nitrophenylester, synthetisiert. tert.-Butyloxycarbonyl- und p-Methoxycarbobenzoxy-L-asparaginsäure lassen sich in die inneren Anhydride umwandeln, aus denen durch Alkoholyse die entsprechenden α-Ester erhalten werden können. Einige Aminosäure-p-nitrobenzylester wurden in einfacher Weise aus den freien Aminosäuren und p-Nitro-benzylalkohol in Gegenwart von Benzolsulfonsäure hergestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730128
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  • 62
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    Zur Struktur der Fulvene, IV. Darstellung und Eigenschaften von Benzofulvenen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 674 (1964), S. 18-27 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Darstellung, Depolmomente und UV-Spektren einer Reihe von Benzofulvenen werden beschrieben. Der Substituenteneinfluß auf Eigenschaften und Struktur der Verbindungen wird diskutiert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646740104
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    Beiträge zur Konstellationsanalyse, XI.!!X. Mitteilung (bzw. XIII. Mitt.): W. Hückel und R. Bross, Liebigs Ann. Chem. 664, 1 (1963). (Solvolyse von Toluolsulfonsäureestern, XIV). Cycloheptanol, cis- und trans-1-Methyl-cycloheptanol-(2) (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 62-77 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Eigenschaften von Cycloheptanol, cis- und trans-1-Methyl-cycloheptanol-(2) und ihren Derivaten werden ermittelt, untereinander und mit denen der analogen Cyclohexanole verglichen, wonach man auch beim 7-Ring von Axial- und Äquatoriallage des Hydroxyls sprechen kann. Bei der Alkoholyse der p-Toluolsulfonate sind, wenn man von den viel größeren Geschwindigkeiten beim 7-Ring absieht, hinsichtlich der gebildeten Reaktionsprodukte bemerkenswerte Ähnlichkeiten vorhanden. Die E2-Abspaltung mit Alkoholat führt überwiegend zum Δ2-Methylcyclohepten, während die E1-Abspaltung aus cis-Toluolsulfonat fast ausschließlich, aus der trans-Form überwiegend (61.5%) Δ1-Methylcyclohepten liefert. Für die Pyrolyse der Acetate gilt wie beim 6- und beim 5-Ring die cis-Abspaltungsregel streng: Aus dem cis-Acetat entsteht nur Δ2-Methylcyclohepten, aus dem trans-Acetat werden Δ1- und Δ2-Isomeres im Verhältnis 45.5:55.5 gebildet.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646720106
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    Über die gemeinsame Einwirkung von elementarem Schwefel und gasförmigem Ammoniak auf Ketone, XXXIX. Einwirkung von Schwefel und Ammoniak auf Tridecanon-(7) und Pentanone-(2). Thiazoline-Δ3 aus α-Mercapto-oxoverbindungen und Oxoverbindungen in Gegenwart von Ammoniak (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 156-178 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Einwirkung von Schwefel und Ammoniak auf Tridecanon-(7), Pentanon-(2), 3-Methyl-pentanon-(2), 3-Äthyl-pentanon-(2) bzw. 4-Methyl-pentanon-(2) entstehen Thiazoline-Δ3, die [außer dem Reaktionsprodukt von Tridecanon-(7)] Gemische von Stellungsisomeren sind. Die Thiazoline-Δ3 wurden auch durch Ringschlußkondensation der isomerenfreien α-Mercaptoketone mit Ammoniak und dem entspr. Keton dargestellt. Nach diesem Prinzip wurden weitere, neue Thiazoline-Δ3 aus α-Mercaptoaldehyden synthetisiert.
    Additional Material: 9 Tab.
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    URL: http://dx.doi.org/10.1002/jlac.19646720112
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    Untersuchungen zur Biosynthese der Mutterkorn-Alkaloide, II (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 223-231 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In der Alaninseitenkette β-[14C]-markiertes 4-[3.3-Dimethyl-allyl]-tryptophan (I) wird ebenso wie in der Allylstellung 14C-markiertes reproduzierbar in Elymoclavin eingebaut (spezif. Einbaurate 4-6%). Ein Konkurrenzversuch mit am Indolkern Tritium-markiertem Amin II führt zu nahezu Tritium-freiem Elymoclavin. Diese Versuche zeigen, daß 4-[3.3-Dimethyl-allyl]-tryptophan oder -tryptamin als Vorstufen der Clavin- und damit auch der übrigen Mutterkornalkaloide anzusehen sind.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646720116
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  • 66
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    Synthese von dl-Mevalonsäure-5-pyrophosphat (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 672 (1964), S. 215-222 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus 3-Hydroxy-3-methyl-Δ5-hexenyl-(1)-phosphat (II) wird über das Phosphoramid III bzw.-morpholid IV mit H3PO4/Pyridin in 42-proz. Ausbeute 3-Hydroxy-3-methyl-Δ5-hexenyl-(1)-pyrophosphat (VII) dargestellt. Daneben entsteht durch intramolekulare Phosphorylierung einer tert.-Hydroxygruppe ein 1.3-Cyclophosphat (XI). Das ungesättigte 1-Pyrophosphat liefert bei der Oxydation mit JO4⊖ in Gegenwart katalytischer Mengen MnO4⊖ DL-Mevalonsäure-5-pyrophosphat (IX). Die Kristallisation gelingt als Dibrucin-Salz.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646720115
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    Nachweis des Dehydrobenzols in der Gasphase (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 673 (1964), S. 1-12 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bis-[2-jod-phenyl]-quecksilber wurde in einem Argon-Strom von 6 Torr verdampft und anschließend bei 700° zersetzt. Die aus der Zersetzungszone austretenden Gase wurden nach Durchlaufen einer Kühlstrecke mit Furan-Dampf zusammengeführt. Das entstandene Dehydrobenzol-Addukt (Dihydronaphthalin-endoxyd) wurde nach Isomerisierung zu α-Naphthol in 0.1-proz. Ausbeute nachgewiesen. - Experimentell und rechnerisch wurde sichergestellt, daß die entgegen der Strömung in die Zersetzungszone diffundierende Furan-Menge wesentlich kleiner war als die erhaltene Naphthol-Ausbeute. Daraus folgt. daß ein Teil der Dehydrobenzol-Molekeln eine zum Verlassen der Heizzone ausreichende Lebensdauer besitzt.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646730102
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    Über die Katalytische Wirkung von Metallsalzen bei der Oxydation primärer aromatischer Amine mit Peressigsäure (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 36-42 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus 3-Nitro-anilin entsteht mit Peressigsäure 3.3′-Dinitro-azoxybenzol, bei Gegenwart gewisser Metallspuren dagegen 3.3′-Dinitro-azobenzol. Kinetische Messungen sprechen für das auf S. 38 angegebene Reaktionsschema. In Gegenwart von Vanadat wird Essigsäure durch Peressigsäure schon bei Raumtemperatur leicht zu CO2 und H2O verbrannt. Dabei entsteht intermediär Formaldehyd, der sich als Bis-[3-nitro-anilino]-methan abfangen läßt.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646750105
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    Hochchlorierte Acyldiazoessigester und ihre Anwendung zur Synthese von Polychlorcarbonsäuren (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 47-59 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Hochchlorierte Acyldiazoester sind aus entsprechenden Carbonsäurechloriden und Diazoessigester in meist glatter Reaktion darstellbar. Durch Verdrängung des Stickstoffs mit Chlor, selektive Reduktion der Carbonylgruppe, OH→Cl-Austausch, Verseifung und Dehydrochlorierung wird eine gezielte Synthese von ungesättigten Polychlorcarbonsäuren ermöglicht. Allylumlagerungen in den Endstufen der Reaktionsfolge wirken erschwerend. Aus Trichloracrylsäurechlorid wird die erwartete Perchlor-pentadien-(1.3)-säure-(5) erhalten. α.β-Dichlor-acrylsäurechlorid liefert jedoch an Stelle der 1H- die 3H-Tetrachlorpentadien-(1.3)-säure-(5) in guter Ausbeute.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646750107
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    Die Chemie der Linalool-oxideHerrn Professor Dr. phil., Dr. rer. nat. h. c., Dr. rer. nat. e. h., Dr. rer. nat. h. c. Karl Ziegler zum 65. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 73-82 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Oxydation von (-)-Linalool mit Persäuren führt zu vier isomeren Oxidoalkoholen, von denen zwei eine Tetrahydrofuran- und die beiden anderen eine Tetrahydropyran-Struktur besitzen. Die Konstitution und Konfiguration dieser Oxide wurde geklärt.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646750110
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    Dehydrierung von Steroiden, IX. Abhängigkeit der Dehydrierung mit Chinonen vom Chinon, Reaktionsmilieu und Steroid (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 109-125 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Das Verhalten der 10-ständigen angularen Methylgruppe (Wanderung, Umlagerung, Abspaltung) bei der Dehydrierung von ungesättigten Steroiden der Cholestan-Reihe mit Chinonen hängt ab von der Art des Chinons, dem Reaktionsmilieu und der Lage der Doppelbindungen im Ausgangssteroid; die Dehydrierung verläuft über Zwischenprodukte des entsprechenden Reaktionstyps. Bei der Dehydrierung mit Phenanthrenchinon scheint dieses bzw. eine sich davon ableitende Verbindung der Acceptor für die aus dem Steroid abgespaltene Methylgruppe zu sein.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646750113
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    Über α-Halogenäther, XVII. Umsetzung von Brenzcatechin-dichlormethylenäther mit O- und N-funktionellen VerbindungenHerrn Prof. Dr. Hellmut Bredereck zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 142-150 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Brenzcatechindichlormethylenäther (I) reagiert mit Alkoholen je nach Reaktionsbedingungen zu 2.2-Dialkoxy-1.3-benzodioxolen oder Alkylchloriden; Carbonsäuren bzw. Carbonsäureanhydride geben mit I Carbonsäurechloride, Äthylenoxyd wird in Dichloräthan übergeführt. Die Struktur eines bei alkalischer Hydrolyse von I entstehenden Produktes wurde aufgeklärt. Carbonylverbindungen tauschen den Sauerstoff gegen zwei Halogenatome aus, ebenso setzen sich Formiate zu Dichloräthern um. Säureamide werden zu Nitrilen dehydratisiert, disubstituierte Säureamide geben entweder Säureamiddichloride oder werden gespalten in Nitril und Alkylchlorid. Mit primären Aminen erhält man je nach Bedingungen Benzdioxolonimide oder trisubstituierte Guanidine. Sekundäre Amine geben Acetale tetrasubstituierter Harnstoffe. Bei tertiären Aminen wurden Entalkylierungen beobachtet.
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    URL: http://dx.doi.org/10.1002/jlac.19646750116
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    Zur Kenntnis der 2-Amino-1.3.4-oxdiazole, XIV.XIII. Mitteilung: H. Gehlen und G. Röbisch, Liebigs Ann. Chem. 665, 132 (1963). 2-Amino-5-arylamino-1.3.4-oxdiazole aus Semicarbaziden und Bromcyan (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 176-179 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Einwirkung von Bromcyan auf 4-Aryl-semicarbazide bilden sich 2-Amino-5-arylamino-1.3.4-oxdiazole.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/jlac.19646750119
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    Heterocyclen mit endocyclischer Schwefel-Stickstoff-Doppelbindung, II. 1-Substituierte 3.4-Dihydro-1H-1.2.4-benzothiadiazin-3-one und 1-substituierte 3.4-Dihydro-1H-1.2.4-benzothiadiazin-3-on-1-oxydeHerrn Professor Dr. Hellmut Bredereck zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 189-199 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch dehydrierende Cyclisierung von 2-Alkylmercapto- und 2-Arylmercaptophenylharnstoffen werden 1-substituierte 3.4-Dihydro-1 H-1.2.4-benzothiadiazin-3-one (XIII) gewonnen. Diese lassen sich mit Kaliumpermanganat zu den 1-substituierten 3.4-Dihydro-1 H-1.2.4-benzothiadiazin-3-on-1-oxyden (XIV) oxydieren.
    Additional Material: 10 Tab.
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    URL: http://dx.doi.org/10.1002/jlac.19646750121
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    Über Merocyanine aus Chinonen und MethylenbasenHerrn Professor Dr. H. Bredereck zum 60. Geburtstag in Freundschaft gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 102-108 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es werden Farbstoffe der Merocyanin-Reihe beschrieben, die durch Umsetzung von Methylenbasen mit Chinonen, Chlorchinonen und Chinonsulfonsäuren entstehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646750112
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    Über Kondensationsprodukte der Catechine, VII. Massenspektrometrische Strukturanalyse der Kondensationsprodukte von Catechin mit Phloroglucin bzw. C-Äthyl-phloroglucinZugleich V. Mitteilung der Reihe “Massenspektrometrische Untersuchungen”; IV. Mitteilung: K. Heyns und H.-F. Grützmacher, Liebigs Ann. Chem. 669, 189 (1963). (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 134-141 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Methyläther der Kondensate von Phloroglucin und C-Äthyl-phloroglucin mit (+)-Catechin werden massenspektrometrisch untersucht. Die Massenspektren dieser Verbindungen stehen nur mit Struktur III (bzw. IIIa1 oder IIIa2) und VI (bzw. VIa1 oder VIa2) im Einklang. Zusammen mit den chemischen Befunden1) wird damit die Struktur III (bzw. IIIa1 oder IIIa2) gesichert.
    Additional Material: 6 Ill.
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    Über eine Synthese von s-TriazinHerrn Professor H. Bredereck zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 174-175 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Umsetzung von N-Formyl-N′.N′-dimethyl-formamidin-dimethylacetal (II) mit Wasser liefert Dimethylformamid, Methanol und s-Triazin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646750118
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    [4-Amino-n-butyl]-β-d-GlucopyranosideHerrn Prof. Dr. Hellmut Brederck zum 60. Geburtstag in herzlicher Freundschaft gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 200-204 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Umsetzung von Tetraacetyl-[4-halogen-n-butyl]-β-D-glucopyranosiden mit NH3 oder primären Aminen entstehen die entsprechenden [4-Amino (bzw. arylamino bzw. aralkylamino)-n-butyl]-β-D-glucoside, deren Acetylderivate kristallin erhalten wurden. Die gleichen Ausgangsverbindungen liefern mit Pyridin die entsprechenden Pyridiniumhalogenide.
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    URL: http://dx.doi.org/10.1002/jlac.19646750122
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    Zur chemischen und sterischen Selektivität der photosensibilisierten O2-Übertragung auf (+)-Limonen und (+)-Carvomenthen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 674 (1964), S. 93-117 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die photosensibilisierte O2-Übertragung auf (+)-Limonen (Ia) und (+)-Carvomenthen (Ib) führt nach Reduktion des dabei entstehenden Hydroperoxyd-Gemisches zu jeweils sechs optisch aktiven Alkoholen, die getrennt identifiziert und deren Anteile am Alkohol-Gesamtgehalt gaschromatographisch bestimmt werden. - Wie bei (+)-Carvomenthen, so erfolgt auch bei (+)-Limonen der Eintritt des Sauerstoffs ausschließlich an der Δ1-Doppelbindung nach dem Schema der “indirekt substituierenden Addition in Allyl-Stellung” unter Bildung sämtlicher nach diesem Prinzip zu erwartender Hydroperoxyde. Die aus der prozentualen Verteilung hervorgehende Stereoselektivität der photosensibilisierten O2-Übertragung läßt sich hier nur mit der bevorzugten Ablösung der quasi-axialen Allylwasserstoffe bei der Hydroperoxyd-Bildung erklären. - Die Mechanismen der photosensibilisierten O2-Übertragung und der thermischen Autoxydation werden anhand der bei (+)-Limonen gefundenen Reaktions-produkte diskutiert und einander gegenübergestellt. - Die meisten der hier durch photosensibilisierte O2-Übertragung dargestellten Alkohole sind auf anderem Wege nicht oder nur schwer zugänglich.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646740111
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    Polycyclische Verbindungen, XIV. Über tri-, tetra- und pentacyclische Verbindungen, die in Beziehung zum Steranthren stehen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 674 (1964), S. 129-152 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird hauptsächlich über die Synthese von 1-Phenyl-1.2.3.9a-tetrahydro-perinaphthanon-(3) (V), 1-Phenyl-3.4-aceperinaphthan (XVIII b), 8.9-Trimethylen-3.4-benzphenanthren (XXIII), 8.9-Trimethylen-5-oxo-5.6.7.8-tetrahydro-1.2-benzanthracen (XXX) und 7-Oxo-naphtho-[1′.2′:4.5]-perinaphthan (XXXIIIa) berichtet. V und XVIII b haben eine Ringanordnung wie der Teilbezirk A, C, E, F bzw. A, C, D, E, F des Steranthrens (1a bzw. 2a), die anderen 3 Verbindungen eine dem Bereich A, B, C, E, F entsprechende. Die Angliederung des Ringes D an XXX und XXXIII a ist nicht gelungen.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/jlac.19646740114
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  • 81
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    Solanum-Alkaloide, XXXVII. Über die Alkaloidglykoside von Solanum polyadenium Greenm.Auszug aus der Habilitationsschrift K. Schreiber, Univ. Jena 1961. Über wesentliche Ergebnisse dieser Untersuchungen wurde auf dem Internat. Symposium “Chemie und Biochemie der Solanum-Alkaloide” am 2. 6. 1959 in Berlin berichtet: vgl. Angew. Chem. 71, 529 (1959); K. Schreiber, U. Hammer, E. Ithal, H. Ripperger, W. Rudolph und A. Weissenborn, Tagungsber. dtsch. Akad. Landwirtsch.-Wiss. Berlin Nr. 27, 47 (1961). (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 674 (1964), S. 168-175 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Blätter und unreife Früchte der mexikanischen Wildkartoffel Solanum polyadenium Greenm. enthalten als Hauptalkaloide (Gesamtalkaloidgehalt 0.5-1.6 bzw. 3-8% des Trockengewichts) 2 Tomatidin-glykoside: Tomatin und ein bisher unbekanntes Glykosid, das “Polyanin” genannt wird. Nach den Ergebnissen von Säurehydrolyse, Perjodsäureabbau und Permethylierung ist Polyanin O(3)-[β-D-Xylopyranosyl(1 → 2Gluc)-β-D-xylopyranosyl(1 → 3Gluc)-β-D-glucopyranosyl]-tomatidin (I).
    Additional Material: 2 Tab.
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  • 82
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    Über die Reaktion von Ketenen mit o-Chinonen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964), S. 110-114 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ketene werden an o-Chinone zu cyclischen Lactonen angelagert. Diese Reaktion eignet sich dazu, Ketene, die bei der Thermolyse von o-Chinondiaziden und Diazoketonen als unbeständige Zwischenverbindungen auftreten, abzufangen. Findet nach der Stickstoff-Abspaltung keine Wolffsche Umlagerung zum Keten statt, so bilden sich aus o-Chinonen und Carben Chinonmonoacetale.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646760113
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  • 83
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    Azachinoxaline (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964), S. 136-140 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Umsetzung von 2.3-Diamino-pyridin mit α-Dicarbonylverbindungen werden Azachinoxaline hergestellt, um Vergleichsmaterial zu den entsprechenden Chinoxalinen zu erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646760117
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  • 84
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    Auf das Zentralnervensystem wirkende Substanzen, XLI. Synthesen neuer, vom 3-Phenyl-3-äthyl-1-propionyl-azetidin abgeleiteter Verbindungen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964), S. 151-160 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird über die Synthese von Verbindungen berichtet, die sich vom antiphlogistisch wirkenden 3-Phenyl-3-äthyl-1-propionyl-azetidin (I) formal durch reduktive bzw. hydrolytische Ringspaltung ableiten (II, VIII, XIV, XX), oder die sich von I in der Ringgröße unterscheiden (XXIII, XXVI, XXIX, XXXV). Die entzündungshemmende Wirkung von I bleibt in den meisten Fällen erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646760119
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  • 85
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    15. Mitteilung über die Inhaltsstoffe von Salvia officinalis L.14. Mitteilung: C. H. Brieskorn und W. Polonius, Pharmazie 17, 705 (1962).. Über das Vorkommen von 2-Methyl-3-methylenhepten-(5) im ätherischen Öl von Salvia officinalis L (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964), S. 171-174 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2-Methyl-3-methylen-hepten-(5) (I) wird im ätherischen Öl von Salvia officinalis L. aufgefunden. Die mögliche Biogenese aus Thujon wird diskutiert.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646760122
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  • 86
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    19-nor-5β-Methyl-steroide, I. Über die Westphalen-Umlagerung von Cholestan-3β.5α.6β-triol-3.6-diacetat (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964), S. 188-202 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die chromatographische Auftrennung des bei der Westphalen-Umlagerung von Cholestan-3β.5α.6β-triol-3.6-diacetat (IV) erhaltenen Reaktionsgemisches ergibt vier Dehydratisierungsprodukte, darunter 19-nor-5β-Methyl-Δ1(10)-cholesten-3β.6β-diol-diacetat (IXa). Die systematische Variation der Umlagerungsbedingungen zeigt, daß die vier Endioldiacetate (VI - VIII, IXa) über einen gemeinsamen, als nicht-klassisches Kation formulierten „transition state“ (XIIIb) entstehen, dessen Umwandlung von der Substitution an C-6 entscheidend beeinflußt wird. Die Bildung des Übergangszustandes erfolgt durch Protonen-Katalyse und konkurriert mit der durch die Acetylium-Ionen bewirkten Acetylierung der 5α-OH-Gruppe. Jeder dieser beiden Prozesse kann zur Hauptreaktion gemacht werden. Aus dem Cholestantrioltriacetat entsteht dabei ein weiteres Umlagerungsprodukt.
    Additional Material: 2 Tab.
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    URL: http://dx.doi.org/10.1002/jlac.19646760124
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  • 87
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    Über Kondensationsprodukte der Catechine, VI. Zur Konstitution der Reaktionsprodukte des (+)-Catechins mit Phloroglucin und C-Äthyl-phloroglucin (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 126-134 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Der Heptamethyläther des Kondensationsproduktes von (+)-Catechin mit Phloroglucin läßt sich weder mit Na/Äthanol noch mit K/Butanol unter Öffnung des Ätherringes hydrieren. Damit scheiden alle Benzyläther-Strukturen aus. - Im Gegensatz zum Phloroglucin liefert C-Äthyl-phloroglucin mit (+)-Catechin zwei isomere Kondensationsprodukte der Zusammensetzung C23H22O8. Ein primäres Additionsprodukt konnte nicht gefaßt werden, seine intermediäre Existenz wird jedoch durch die Bildung der Isomeren offenbar. Auch hier verlaufen die Reaktionen an C-2 und C-3 stereospezifisch. Auf die Leichtigkeit und Selektivität des Ätherringschlusses durch den addierten Phloroglucin-Kern wird hingewiesen.
    Additional Material: 2 Tab.
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  • 88
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    Umsetzungen α.β-ungesättigter β-Amino- und β-Hydroxy-carbonylverbindungen mit Dischwefeldichlorid und verwandten VerbindungenHerrn Prof. Dr. H. Bredereck zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 151-174 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α.β-Ungesättigte β-Amino- und β-Hydroxy-carbonylverbindungen  -  offenkettige Aldehyde, Ketone, Ester, cycloaliphatische und heterocyclische Derivate sowie Vertreter der Chinonreihe  -  liefern mit Dischwefeldichlorid vornehmlich Sulfide, mitunter auch Disulfide. Sulfide entstehen auch mit Schwefeldichlorid, Morpholin-N-sulfenylchlorid, Bis-dimethylamino-sulfid und Thionylchlorid. - Umsetzungen der so hergestellten Sulfide und Disulfide führen zu heterocyclischen Sulfiden, Disulfiden und Mercaptanen (Pyrimidinen, Pyrazolen und Isoxazolen), zu 1.4-Oxathiinen und zu Anilen der Sulfide und Disulfide von β-Arylamino-acroleinen.
    Additional Material: 1 Tab.
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  • 89
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    Zur Kenntnis der 1.2.4-Triazolone-(5), IV.III. Mitteilung: H. Gehlen, J. Dost und J. Cermak, Liebigs Ann. Chem. 639, 100 (1961). Bildung von 1.2.4-Triazolonen-(5) aus substituierten Acylsemicarbaziden (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 180-188 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Beim alkalischen Verkochen von 1-Acyl-4-alkyl(aryl)-semicarbaziden findet Ringschluß zu den 3.4-disubstituierten 1.2.4-Triazolonen-(5) statt. Aus 1-Acyl-2-aryl- und 1-Acyl-2.4-diaryl-semicarbaziden entstehen 1.3- bzw. 1.3.4-substituierte 1.2.4-Triazolone-(5).
    Additional Material: 4 Tab.
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  • 90
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    Masthead (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 676 (1964) 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646760101
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  • 91
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    Die intramolekulare Wechselwirkung zwischen Heterocyclen in Coenzymen, I. Nicotinamid-Mercaptopurin-, Nicotinamid-Methylmercaptopurin-und Nicotinamid-Purin-Dinucleotid (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 675 (1964), S. 205-212 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 6-Mercapto-9-[2′.3′-isopropyliden-β-D-ribofuranosyl]-purin reagiert mit Cyanäthylphosphat und Dicyclohexylcarbodiimid zum 5′-Phosphat. Mit Methyljodid erhält man den Methylthioäther, der sich in guter Ausbeute phosphorylieren läßt. Durch Abspaltung der Methylmercapto-Gruppe mit Raney-Nickel entsteht 9-[β-D-Ribofuranosyl]-purin-5′-phosphat. Die Nucleotide werden mit Nicotin-amid-Mononucleotid zu den Coenzym-Analoga Nicotinamid-Mercaptopurin-, Nicotinamid-Methylmercaptopurin- und Nicotinamid-Purin-DinucleotidEs werden folgende Abkürzungen verwendet: Nicotinamid-Mercaptopurin-Dinucleotid = NMD, Nicotinamid-Methylmercaptopurin-Dinucleotid = NMMD, Nicotinamid-Purin-Dinucleotid = NPD, Nicotinamid-Adenin-Dinucleotid = NAD. - Hydrierte Formen: NMDH, NMMDH, NPDH, NADH. kondensiert. Bei den S-haltigen Dinucleotiden läßt sich eine Wechselwirkung zwischen den beiden Heterocyclen im oxydierten und reduzierten Zustand UV-spektroskopisch feststellen. Die synthetisierten Dinucleotide sind biochemisch aktiv, die S-haltigen werden 2 - 3 mal fester an das Enzym gebunden als das natürliche Nicotinamid-Adenin-Dinucleotid. Das Nicotinamid-Purin-Dinucleotid zeigt gegenüber dem natürlichen Coenzym keinen wesentlichen Unterschied.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646750123
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  • 92
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    Isoxazolino-steroide durch 1.3-dipolare Addition (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 677 (1964), S. 139-149 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Einwirkung von Benzo- bzw. Acetonitriloxyd auf 16-Dehydro-20-oxopregnene (z. B. auf VI und X) werden durch 1.3-dipolare Addition [17.16-d]-3′-Phenyl- bzw. -3′-Methyl-isoxazolino-20-oxo-pregnene (z. B. XIII, XVII bzw. XXI, XXIV) erhalten. [17.16-d]-3′-Phenyl- bzw. -3′-Methyl-isoxazolino-3′ -acyloxy-20-oxo-Δ5-pregnene (z. B. XIII und XXI) werden alkalisch zu den 3-Hydroxy-Δ5-Derivaten (z. B. XIV und XXII) verseift und diese nach Oppenauer zu [17.16-d]-3′-Phenyl- bzw. -3′-Methyl-isoxazolino-3.20-dioxo-Δ4-pregnenen (z. B. XVII und XIV) oxydiert. Addition obiger Nitriloxyde an 2-Benzyliden-5α-androstanol-(17ß)-on-(3) führt zu [5α-Androstranol-(17ß)-on-(3)]-2-spiro-4′-[3′.5′ -diphenyl-isoxazolin] bzw. -[3′-methyl-5′ -phenyl-isoxazolin] (XXXIII bzw. XXXIV).
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    URL: http://dx.doi.org/10.1002/jlac.19646770120
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  • 93
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    Die Umsetzung ungesättigter Kohlenwasserstoffe mit 2.4-Dinitro-benzoldiazoniumsalz, II1) Einfluss von Alkyl- und Arylgruppen auf die Reaktionsfähigkeit der KohlenstoffdoppelbindungMeinem verehrten Lehrer, Herrn Prof. Dr. Dr. h. c. H. Meerwein, zum 85. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 28-38 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Spaltung der C=C-Bindung durch Diazoniumionen verläuft nach dem Zeitgesetz 2. Ordnung. Sie ist in hohem Maße von der Substitution an den die Doppelbindung einschließenden C-Atomen abhängig und kann daher verwendet werden, um den Substituenteneinfluß zu untersuchen. Ein Schema der Spaltungsreaktion wird angegeben.
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    URL: http://dx.doi.org/10.1002/jlac.19646780106
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  • 94
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    Über 1.2-Dithia-cyclopentene, IVIII. Mitteilung: F. Boberg und A. Marei, Liebigs Ann. Chem. 666, 88 (1963); Teil der Habilitationsschrift F. Boberg, Techn. Hochschule Hannover 1963.. Halogenierung von 5-Phenyl-1.2-dithia-cyclopentenon-(3) (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 67-77 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Halogenierung von 5-Phenyl-1.2-dithia-cyclopentenon-(3) (I) treten Substitution (zu IV bzw. V) und Halogenolyse (zu VII bzw. VIII) ein. Die Substitution ist bei der Bromierung stärker bevorzugt als bei der Chlorierung. Der Reaktionsmechanismus wird diskutiert. Die letztlich zu 1.2-Dichlor-inden-(1)-on-(3) (XII) führende Umsetzung von cis- und trans-α.β-Dichlor-zimtsäure (IXa bzw. b) mit SOCl2 wird untersucht. I ist außer aus Zimtsäureäthylester auch aus Zimtsäurechlorid mit Schwefel zugänglich.
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  • 95
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    Reaktionen mit Diazocarbonylverbindungen, XIII1) Über anomale o-Chinontriphenylphosphazine (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 127-132 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bei der Umsetzung von 1 Mol. Triphenylphosphin mit o-Chinondiaziden hoher elektrophiler Aktivität erhält man labile, tieffarbige Primäraddukte (z. B. II), die mit einem weiteren Mol. Triphenylphosphin salzartige, gelbe Diaddukte (z. B. IV) bilden. Das salzartig gebundene, zweite Molekül Triphenylphosphin kann durch N.N-Dimethyl-formamid ersetzt werden.
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    URL: http://dx.doi.org/10.1002/jlac.19646780113
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  • 96
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    Über Herzglykoside, XX19. Mitteilung: F. Kaiser, E. Haack und H. Springler, Naturwissenschaften 50, 668 (1963).. Neue Genuine Glykoside aus den Blättern von Digitalis Lanata Ehrh (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 137-147 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Nach chromatographischer Auftrennung der Äthanolextrakte unfermentierter Blätter von Digitalis lanata an Silicagel-und Cellulose-Säulen werden die Primärglykoside Gluco-evatromonosid (Digitoxigenin-digilianidobiosid, I), Gluco-gitorosid (Gitoxigenin-digilanidobiosid, II), Gluco-lanadoxin (Gitaloxigenin-digilanidobiosid, III), Gluco-verodoxin (V) und Odorobiosid G (IV) isoliert.
    Additional Material: 1 Ill.
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  • 97
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    Synthetische Peptide als HydrolasemodelleEs werden, außer den für die Aminosäuren üblichen, folgende Abkürzungen verwendet: Me = Methyl, Et = Äthyl, t.-But = tert.-Butyl, Bz = Benzyl, Nbz = p-Nitro-benzyl, Cbo=Carbobenzoxy, Phth=Phthalyl. (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 148-159 
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    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird die Synthese der Oligopeptide bzw. Ester L-Glu-L-Ser-L-Ala-Gly-Gly (I), L-Glu-L-Ala-Gly-Gly (II), L-Glu-L-Ser-Gly-Gly-L-His-OMe (III) und L-Glu-Gly-Gly-L-His-OMe (IV) beschrieben. Fast alle Peptidbindungen werden mittels Diphenylketens geknüpft. Mit p-Nitro-phenylacetat als Substrat unter Standardbedingungen ergeben sich Beziehungen zwischen der Aminosäurezusammensetzung des Peptides und seiner esteratischen Aktivität. Peptide, welche die am aktiven Zentrum der Hydrolasen beteiligten Aminosäuren Serin und Histidin enthalten, zeigen die höchste Hydrolysegeschwindigkeit.
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  • 98
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    Derivate von Naphthalin, Phenanthren, Anthracen und 2.3-Benzthiophen aus 4H-Pyranen und 4H-Thiopyranen (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 678 (1964), S. 202-213 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es Wird über eine mit guten Ausbeuten verlaufende Synthese des Naphthalin-Ringsystems aus Derivaten von 4H-Pyran unter Abspaltung eines Ketons durch 70-proz. Perchlorsäure berichtet. Der Mechanismus der Reaktion wird besprochen.
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    URL: http://dx.doi.org/10.1002/jlac.19646780120
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    Versuche zum Vorgang der Wasserstoffübertragung, IX. Der H-D-Austausch zwischen Toluol und Deuteriumgas in Gegenwart von Raney-NickelHerrn Prof. Dr. Otto Horn in freundschaftlicher Verbundenheit zum 60. Geburtstag gewidmet (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 679 (1964), S. 1-9 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Der durch Raney-Nickel bei Raumtemperatur und unter Normaldruck katalysierte H-D-Austausch zwischen Toluol und Deuteriumgas wurde untersucht. Dabel wurden durchschnittlich 1.4 D-Atome pro Molekül eingeführt. Die Positionsbestimmung des eingeführten Deuteriums mittels Abbau- und Substitutionsreaktionen in Kombination mit Deuteriumbestimmungen ergab: 1) Alle H-Atome im Toluol sind dem H-D-Austausch zugänglich. 2) Die Seitenkette enthält mehr als die Hälfte des eingeführten Deuteriums. 3) m-Stellung und p-Stellung enthalten etwa gleich viel Deuterium. 4) Der Deuteriumgehalt der o-Stellung liegt weit unter dem der m- und p-Stellung.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646790102
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  • 100
    Electronic Resource
    Electronic Resource
    Organische Fluorverbindungen, VII. Synthese von 10-Fluor- und 14-Fluor-vitamin-A-acetat (1964)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 679 (1964), S. 20-26 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ß-Jonyliden-ß-fluor-äthanol (III) wird mit MnO2 zu ß-Jonyliden-ß-fluor-acetaldehyd (IV) oxydiert. Aus IV entsteht durch Olefinierung mit dem Carbanion des 4-Diäthylphosphono-3-methyl-crotonsäureesters (cis, trans-Gemisch) 10-Fluor-vitamin-A-säureester, aus ß-Jonyliden-acetaldehyd mit 4-Diäthylphosphono-2-fluor-3-methyl-crotonsäureester (cis, trans-Gemische) analog 14-Fluor-vitamin-A-säureester. Beide Fluorester (cis, trans-Gemische) lassen sich mit LiAlH4 zum Fluor-vitamin-A reduzieren. Acetylierung mit N-Acetyl-imidazol ergibt 10-Fluor- bzw. 14-Fluor-vitamin-A-acetat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19646790104
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