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  • 1985-1989
  • 1975-1979  (2,777)
  • 1976  (2,777)
  • Polymer and Materials Science  (2,626)
  • Electron microscopy  (128)
  • pharmacokinetics
Source
Material
Years
  • 1985-1989
  • 1975-1979  (2,777)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    An electron microscopic study of plasmatic arterionecrosis in the human cerebral arteries (1976)
    Springer
    Virchows Archiv 369 (1976), S. 181-190 
    Details
    ISSN: 1432-2307
    Keywords: Cerebral hemorrhage ; Cerebral artery disease ; Plasmatic arterionecrosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An electron microscopic study of the intracerebral arteries from 9 hypertensive cases was performed in order to elucidate the morphogenesis of the plasmatic arterionecrosis which was considered to be the direct cause of hypertensive intracerebral hemorrhage. In the preceding stage of the arterial lesions, marked necrosis of medial smooth muscle cells and increase of basement membrane-like substance in the intima and media were observed. The lumina of these arteries were slightly dilated. The dilatation and hemodynamic factors were supposed to cause endothelial injury resulting in blood plasma insudation into the intima through the opened spaces between endothelial cells. The insudated blood plasma dispersed and dissolved the basement membrane-like substance, collagen and elastic fibers in the arterial wall, leading to the development of the plasmatic arterionecrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427707
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  • 2
    Electronic Resource
    Electronic Resource
    Experimentell induzierte Herzmuskelfasernekrosen nach Praemedikation mit Strophanthin (1976)
    Springer
    Virchows Archiv 370 (1976), S. 141-150 
    Details
    ISSN: 1432-2307
    Keywords: Angiotensin ; Catecholamine ; Strophanthin ; Rat heart ; Myocardial necroses ; Optical microscopy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der Ratte nehmen die durch Angiotensin induzierten Herzmuskelfasernekrosen (75 mg/kg s.c. und i.p.) unter Strophanthin-Praemedikation (2 × 10−2 mg/kg i.p.) an Zahl und Ausmaß ab. Darüberhinaus ändert sich der elektronenmikroskopische Befund: Die alleinige Gabe von Angiotensin bewirkt eine Vakuolisation der Mitochondrion und eine Dilatation des endoplasmatischen Reticulum ohne Alteration der Myofibrillen. Die kombinierte Gabe von Strophanthin und Angiotensin führt zu einer primären Zerstörung der Myofibrillen, ohne daß Mitochondrien und tubuläres System sichtbar verändert werden. Der Schutzmechanismus des Strophanthin wird im Sinne einer Ökonomisierung des Zellstoffwechsels bei relativer coronarieller Insuffizienz diskutiert, welche durch die starke vasokonstriktorische Wirkung des Angiotensin ausgelöst wird.
    Notes: Summary Number and degree of angiotensin-induced heart muscle necroses in the rat (75 mg/kg body weight) are diminuished by premedication with strophanthin (2 × 10−2 mg/kg body weight). The electron-microscopic findings are also changed: the application of angiotensin only results in vacuolization of mitochondria and a dilatation of the endoplasmatic reticulum while myofibrils are unaltered. Angiotensin in combination with strophanthin has a direct destructive effect on the myofibrils without evident changes of the mitochondria and the tubular system of the heart. The protective action of Strophanthin on the heart muscle cell is discussed in the sense of an economization of the cellular metabolism under conditions of relative coronary insufficiency, induced by the vasoconstructive effect of angiotensin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430810
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  • 3
    Electronic Resource
    Electronic Resource
    Hairy cell leukemia (1976)
    Springer
    Virchows Archiv 370 (1976), S. 273-289 
    Details
    ISSN: 1432-2307
    Keywords: Bone marrow biopsy ; Hairy cell leukemia ; Differential diagnosis ; Myelofibrosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 24 patients with hairy cell leukemia, histological and fine structural findings from biopsies of the bone marrow are reported and their validity is compared with other diagnostic procedures available. Diagnosis by light microscopy of anterior iliac crest biopsies obtained by the method of myelotomy is possible with a high degree of accuracy. The differentiation of hairy cell leukemia from other myelo- or lymphoproliferative disorders based on cytomorphology as well as patterns of growth is emphasized. Morphological differences between fibrosis in this entity and other lesions such as malignant lymphomas, Hodgkin's disease, osteomyelofibrosis and -sclerosis are emphasized. Electron microscopy of the bone marrow shows single fibroblastic cells with numerous slender cytoplasmic processes randomly dispersed among the hairy cells. These fibroblasts are probably responsible for the synthesis of the reticulin and collagen fibres in their surroundings. Moreover fine structure of the hairy cells demonstrates pinocytic activity but no apparent phagocytosis in contrast to the phagocytic reticulum cells (histiocytes, macrophages). In the bone marrow the precursor cells and the many immature forms of hairy cells exhibit an overall lymphocytoid appearance during their maturation, suggesting a lymphocytic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445773
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  • 4
    Electronic Resource
    Electronic Resource
    Specificity of innervation of iris musculature by sympathetic nerve fibres in tissue culture (1976)
    Springer
    Pflügers Archiv 361 (1976), S. 127-134 
    Details
    ISSN: 1432-2013
    Keywords: Tissue culture ; Fluorescence histochemistry ; Electrophysiology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Irides from 3–5 day old rats have been grown 1–3 mm from superior cervical or lumbar paravertebral sympathetic ganglia in modified Rose chambers. The two muscles of the iris received distinctly different innervation patternsin vitro, and these were similar to those seenin vivo. Varicose, adrenergic fibres were consistently associated with the dilator pupillae rather than with the sphincter pupillae while excitatory, cholinergic junctions developed between the nerve fibres and the muscle cells of the sphincter but not the dilator. There was a lack of specificity shown by the sympathetic neurons during this innervation. Fibres from lumbar ganglia formed plexuses within the dilator similar to those formed by superior cervical fibres, and sympathetic, cholinergic fibres were able to substitute for the normal parasympathetic, cholinergic fibres in the sphincter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583456
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  • 5
    Electronic Resource
    Electronic Resource
    Fluorescence histochemical and electron-microscopical observations on the innervation of the atrial myocardium of the adult human heart (1976)
    Springer
    Virchows Archiv 371 (1976), S. 101-119 
    Details
    ISSN: 1432-2307
    Keywords: Human heart ; Innervation ; Fluorescence histochemistry ; Electron microscopy ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The existence of both adrenergic and cholinergic innervation of the atrial myocardium of the adult human heart was demonstrated by means of fluorescence induced by formaldehyde or glyoxylic acid and by electron microscopy. The adrenergic fluorescing axons (1) followed the course of blood vessels as typical perivascular nerve plexuses, and (2) formed a three-dimensional fairly dense nerve net obviously not related to the blood vessels. The varicosities frequently came into close apposition on myocardial cells. Several types of nerve terminals were differentiated at electron microscopy: (1) an “adrenergic” type containing small (diameter 450–700 Å) dense-cored vesicles and usually (in various proportions) small “empty” and/or large (900–1500 Å) dense-cored vesicles, (2) a “cholinergic” type containing small (ca. 500 Å) “empty” vesicles and occasionally also some large (mean diameter ca. 1200 Å) dense-cored vesicles, (3) a “pale” type containing only a few or no vesicles, (4) a “disintegrated” type containing degenerated mitochondria, autophagic vacuoles, and occasional normal-looking mitochondria, (5) nerve terminals containing a large number of mitochondria in addition to varying vesicle populations, and (6) a (possibly baroreceptive type of) nerve terminal containing myelinlike lamellated structures. The “disintegrated” and the “pale” types of nerve terminals possibly represent different stages of axonal degeneration, or may correspond to diminution in the transmitter substance concentration under certain pathophysiologic conditions, respectively. Nerve terminals crowded with mitochondria may be sensory and involved in mechano-or chemoreceptive functions. In preliminary experiments convincing evidence was obtained that the glyoxylic acid-induced fluorescence histochemical method will be suitable for comparative studies on (human) clinical specimens, e.g., for analyzing the degree of the functional activity of the intrinsic adrenergic innervation of the myocardium under various pathophysiologic conditions. The modification which appeared most appropriate for such studies is described in detail, and is proposed for use as a standard method in other similar or related studies on human clinical series. The essential criteria for analyzing the specimens at fluorescence microscopy are suggested as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00444927
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  • 6
    Electronic Resource
    Electronic Resource
    Stereology of liver biopsies from healthy volunteers (1976)
    Springer
    Virchows Archiv 371 (1976), S. 251-263 
    Details
    ISSN: 1432-2307
    Keywords: Human liver ; Electron microscopy ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The stereologioal model and the base-line data of normal human liver needle biopsy-specimens are presented. Four reference systems were introduced: 1 cm3 of liver tissue, 1 cm3 of hepatoeyte, 1 cm3 of hepatocytic cytoplasm and the volume of an average “mononuclear” hepatocyte. The sampling was done at three levels of magnification (1,000 ×, 5,000 × and 10,000 ×). A lobular differentiation was not considered. The baseline data show strikingly small variations (s.e. less than 10%) within the individual biopsy specimen and within the group of four biopsies. There is no principal difference between human beings presented here, rats, mice and dogs. Only the mean individual volume of human hepatocytes is clearly larger than in rodents. The problems and limitations of stereological work on liver biopsy specimens are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433072
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  • 7
    Electronic Resource
    Electronic Resource
    Cellular differentiations and structural characteristics in nasopharyngeal angiofibromas (1976)
    Springer
    Virchows Archiv 371 (1976), S. 273-282 
    Details
    ISSN: 1432-2307
    Keywords: Nasopharyngeal angiofibroma ; Fibroblast ; Vascular cells ; Fibromatosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An electron-microscopic study of 9 nasopharyngeal angiofibromas was performed in order to elucidate the ultrastructural characteristics. Stromal fibroblasts and proliferating cells of the microvasculature were found. The stromal fibroblasts were subdivided into 3 different groups: (1) “classical” fibroblasts, (2) fibroblasts with histiocytelike features, and (3) fibroblasts with myoid features. By proliferation the cells of the capillary vessels change into stromal cells. A particular pattern of nuclei and dense intranuclear granules is only found in stromal fibroblasts. Consequently fibroblasts as well as cells of the microvasculature contribute to the pool of tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433074
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  • 8
    Electronic Resource
    Electronic Resource
    Metabolism and ultrastructure in ovaries of alloxan-diabetic juvenile rats (1976)
    Springer
    Archives of gynecology and obstetrics 220 (1976), S. 199-208 
    Details
    ISSN: 1432-0711
    Keywords: Rat ovaries ; Diabetes mellitus ; Alloxan ; ATP/ADP ; Lactate/pyruvate ; NADP/NADPH ; Glucose ; Protein content ; Hydrogen-coveying enzymes ; alkal. phosphatase ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde der Einfluß eines alloxan-induzierten Diabetes mellitus auf den Stoffwechsel und die Ultrastruktur juveniler Rattenovarien untersucht. Der Diabetes mellitus bewirkte folgende Änderungen imStoffwechsel: Abfall der Konzentration von ATP und NADPH, Anstieg des Lactat/Pyruvat-Quotienten über 40, Abfall des ATP/ADP-Quotienten unter 1, Aktivitätsminderung der wasserstoffübertragenden Enzyme G-6-DH, Isocitrat-DH, Malat-DH, Aktivitätszunahme der alkalischen Phosphatase, Erniedrigung des Proteingehaltes.Ultrastruktur: Nahezu vollständiges Verschwinden des rauhen endoplasmatischen Reticulums, Schrumpfung der Mitochondrien, Reduktion der cristae und Kondensation der Matrix. Das glatte endoplasmatische Reticulum bleibt unverändert, der Golgi-Komplex ist in seiner Ausdehnung reduziert. Leichte Extrahierbarkeit der Lipiddepots. Die Befunde sprechen für eine Hemmung der oxydativen Phosphorylierung sowie für eine Beeinträchtigung des Steroid- und Proteinstoffwechsels.
    Notes: Summary Tests were carried out on the influence of alloxan-induced diabetes mellitus on the metabolism and the ultrastructure of ovaries of juvenile rats. The diabetes mellitus caused the following changes in themetabolism: reduction in the concentration of ATP and NADPH, increase in the lactate/pyruvate quotient to above 40, reduction in the ATP/ADP quotient to below 1, reduction in the level of activity of the hydrogen-conveying enzymes G-6-P-dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase, increase in the level of activity of the alkaline phosphatase, reduction of the protein content. Ultrastructure almost complete disappearance of the rough endoplasmic reticulum, shrinkage of the mitochondria, reduction of the cristae and condensation of the matrix. The smooth endoplasmic reticulum remains unchanged, the extent of the Golgi-complex is reduced. Easy removal of the lipid deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00667748
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure of the labyrinth in the rat full-term placenta (1976)
    Springer
    Anatomy and embryology 149 (1976), S. 123-148 
    Details
    ISSN: 1432-0568
    Keywords: Rat-placenta ; Gap junctions ; Electron microscopy ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The placental labyrinth of the chorioallantoic placenta of the rat was studied with transmission and scanning electron microscopy. Full-term placentas were investigated after perfusion fixation from the maternal and fetal circulation, including thin-sectioning and freeze-fracturing. The labyrinthal three-dimensional structure was found not to be trabecular but spongious lamellar. We propose a division of the lamellae into three groups—the first, second, and third order. The trophoblastic layers are described in detail, showing a cellular layer I and two syncytial layers II and III. Layer I is found to be fenestrated and highly permeable. Layers II and III are connected by extended gap junction areas. It is suggested that the gap junctions function as a molecular sieve and represent the limiting barrier in diaplacental transport of the choriollantoic placenta. Fetal capillaries are fenestrated and endothelial cells are connected by tight junctions. The functional significance of the morphologic findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317893
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  • 10
    Electronic Resource
    Electronic Resource
    Studies on experimental malignant nerve sheath tumors maintained in tissue and organ culture systems II. Electron microscopy observations (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 293-310 
    Details
    ISSN: 1432-0533
    Keywords: Experimental malignant Schwannomas ; Organ culture ; Electron microscopy ; Differentiation ; Microtubules ; Basal lamina ; Perineurial fibroblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sequential electron microscopic features of six malignant nerve sheath tumors (three cranial and three spinal) induced in rats by transplacental ethylnitrosourea and maintained in organ culture systems were compared with those of a human acoustic Schwannoma similarly cultured. After 4 weeks in vitro, the malignant tumor cells often showed progressive elongation of their processes, with the development of an interdigitating pattern resembling that seen in well-differentiated Schwannomas. This was accompanied by an increase of microtubules. Basal lamina formation, less well-developed and less complete than in the benign Schwannoma in this study, was maintained in culture. Some explants demonstrated an increase in number and width of collagen fibrils, accompanied by a relative concomitant decrease of intercellular basement membrane material. The malignant tumor cells also showed numerous micropinocytotic vesicles and various junctional complexes, which are characteristic of perineurial cells. Since the origin of the experimental tumors from adult Schwann cells seems well established, this apparent contradiction is best resolved by the concept that Schwann cells and perineurial fibroblasts are functional variants of the same cell type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696559
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  • 11
    Electronic Resource
    Electronic Resource
    Vacuolation of oligodendroglia in neoplastic perifocal edema (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 1-12 
    Details
    ISSN: 1432-0533
    Keywords: Cytoplasmic vacuole ; Oligodendroglia ; Brain edema ; Metastatic carcinoma ; Glioma ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vacuolation of oligodendroglia, a new type of cytopathological change, has been described. The change is observed frequently at the perifocally edematous cerebral white matter adjacent to the metastatic lesions of carcinoma from the lung in all three cases examined. It is also present occasionally in association with astrocytoma. This condition is characterized by swelling of oligodendroglias due to numerous cytoplasmic vacuolations which contain the material identical with that of the extracellular edema fluid. In such cells, the nucleus is displaced and deformed by vacuoles but the nuclear chromatin and envelopes are arranged normally. By occupation of numerous large vacuoles the cytoplasm is divided into small areas, but the individual organelles are only minimally altered. The oligodendroglial vacuolation seems to be a phagocytic response to the edema fluid which contains proteinous macromolecules derived from blood-borne protein and necrotic material of brain tissue and neoplastic cells. The vacuolation may result in some oligodendroglial dysfunction in maintenance of myelin and probably be related with diffuse loss of myelin sheath in the longstanding brain edema secondary to neoplastic invasion. The vacuolated cells can be identified with light and electron microscopes in Epon-embedded sections of surgically removed tissue but not in paraffin sections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688939
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  • 12
    Electronic Resource
    Electronic Resource
    The target phenomenon in human muscle (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 329-338 
    Details
    ISSN: 1432-0533
    Keywords: Muscle pathology ; Target muscle fibre ; Targetoid muscle fibre ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A large number of target fibres is observed in a muscle biopsy from a patient with an acute flaccid paraplegia of the lower limbs due to a polyneuroradiculopathy of unknown origin. With the electron microscope up to 4 structural zones are seen in the target fibers. The histochemical and ultrastructural observations in this case, suggest that the “target fibre” phenomenon is due to a disturbed trophic influence of the nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696562
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  • 13
    Electronic Resource
    Electronic Resource
    Purification, some properties and quaternary structure of thed-ribulose 1,5-diphosphate carboxylase ofAlcaligenes eutrophus (1976)
    Springer
    Archives of microbiology 110 (1976), S. 157-166 
    Details
    ISSN: 1432-072X
    Keywords: d-Ribulose 1,5-diphosphate carboxylase ; Oxygenase activity ; Quaternary structure ; Electron microscopy ; Alcaligenes eutrophus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract d-Ribulose 1,5-diphosphate carboxylase has been purified from autotrophically grown cells of the facultative chemolithotrophic hydrogen bacteriumAlcaligenes eutrophus. The enzyme was homogeneous by the criteria of polyacrylamide gel electrophoresis. The molecular weight of the enzyme was 505000 determined by gel filtration and sucrose density gradient centrifugation, and a sedimentation coefficient of 18.2 S was obtained. It was demonstrated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis that the enzyme consists of two types of subunits of molecular weight 52000 and 13000. Electron microscopy on the intact and the partially dissociated enzyme lead to the construction of a model for the quaternary structure of the enzyme which is composed of 8 large and 8 small subunits. The most probable symmetry of the enzyme molecule is 4:2:2. Michaelis constant (K m ) values for ribulose 1,5-diphosphate, Mg2-, and CO2 were 0.59 mM, 0.33 mM, and 0.066 mM measured under air. Oxygen was a competitive inhibitor with respect to CO2 suggesting that the enzyme also exhibits an oxygenase activity. The oxygenolytic cleavage of ribulose 1,5-diphosphate was shown and a 1:1 stoichiometry between oxygen consumption and 3-phosphoglycerate formation observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690223
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  • 14
    Electronic Resource
    Electronic Resource
    Intracelluläre Organisation phagenschwanz-ähnlicher Bacteriocine der Gruppe A in Serratia marcescens (1976)
    Springer
    Archives of microbiology 111 (1976), S. 175-183 
    Details
    ISSN: 1432-072X
    Keywords: Serratia marcescens ; (Phage tail) bacteriocin ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Die Genese eines phagenschwanzähnlichen Bacteriocins in Zellen des Gruppe A-bacteriocinogenen (bA+) Serratia marcescens-Stammer Nr. 16 wurde nach Mitomycin C (MC) Induktion elektronenoptisch untersucht. Dieses Bacteriocin (Gesamtlänge 117 nm) besteht aus einem hohlen Stift mit kontraktiler Scheide. Nach 60 min Induktion wurden in Dünnschnitten stäbchenförmige Bacteriocine identifiziert. Sie erscheinen in drei Aggregationsformen: 1. als hexagonale Einschlüsse, 2. als Bänder dicht nebeneinanderliegender Bacteriocine und 3. als Stapel von übereinanderliegenden Bacteriocinschichten, wenn nach 120 min Induktion ein Maximum von ca. 450 Bacteriocinen pro Zelle erreicht wird. Bacteriocine konnten nach der gleichen Induktionszeit von 60 min auch mit der “in situ lysis technique” nachgewiesen werden. Neben Bacteriocinen traten relativ selten und unregelmäßig auch Phagenköpfe auf. Die Stäbchenform teilungsfähiger Zellen blieb bis zum Auftreten von intracellulären Bacteriocinen erhalten. Ihre Umwandlung in geblähte, sphäroplastenähnliche Zellformen, die nach 120 min Induktion lysierten, war zeitlich korreliert mit Feinstrukturveränderungen der Zellwand.
    Notes: Abstract The biosynthesis of a phage tail-like Bacteriocin by cells of the group A-bacteriocinogenic (bA+ Serratia marcescens strain no. 16 after induction with mitomycin C (MC) was examined electronmicroscopically. This bacteriocin (total length 117 nm) consists of a hollow core and a contractile sheath. At 60 min following induction, rod-like bacteriocin-partieles were identifiable in ultrathin sections. The particles were found to comprise three morphologically different forms of aggregation: 1. hexagonal inclusions, 2. contiguous, bank-like particles, and 3. staples of superimposed layers of bacteriocin particles. At 120 min after induction bA+ cells revealed maximally 450 bacteriocin particles. Similarly, the phage tail particles could be demonstrated with the “in situ lysis technique” at 60 min following induction. Occasionally, phage heads were demonstrable, but in no instance were complete phage particles discernible. Dividing cells of the bA+ strain of S. marcescens maintained their rod-form following induction with MC until intracellular phage tail bacteriocin particles were seen. However, at 120 min after induction, the swollen, sphaeroplast-like cells lysed, an event that could be correlated with fine structural alterations of the cell wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446566
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  • 15
    Electronic Resource
    Electronic Resource
    Bioavailability of various preparations and doses of penicillin V (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 55-58 
    Details
    ISSN: 1432-1041
    Keywords: Penicillin V ; bioavailability ; pharmacokinetics ; dose ranging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary An absorption study was performed in ten healthy volunteers to test the bioavailability of various doses of two penicillin V-K preparations: Isocillin® (Hoechst AG, Federal Republic of Germany), — tablets of 600 000 and 1.2 Mega U; V-Cillin® (Eli Lilly, USA), — tablets of 200 000, 400 000 and 800 000 U. The serum concentrations and elimination of the active substance in urine were measured for six hours after administration. Independently of the source of the preparation, a strict linear relation between the dose and the area under the serum curve (AUC), or between the dose and the urinary elimination, was demonstrated by regression analysis. The dose-dependent increase in the AUC was highly significant (p〈0.01) in the range tested, i.e. between 200 000 and 1.2 Mega U. The relative elimination of active substance in urine lay within narrow limits for all doses (35.7–41.3%). Thus, both compounds proved to have the same bioavailability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561550
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  • 16
    Electronic Resource
    Electronic Resource
    Ampicillin: Comparison of bioavailability and pharmacokinetics after oral and intravenous administration of three brands (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 237-243 
    Details
    ISSN: 1432-1041
    Keywords: Ampicillin ; bioavailability ; pharmacokinetics ; branded products ; proprietary preparations ; capsule formulation ; tablet formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of three different brands of ampicillin were studied in 10 volunteers. After intravenous administration ampicillin can be described adequately by a two-compartment open pharmacokinetic model. The half-life during the α-phase was 9 min and the β-half-life was in the range 50–60 min, independent of the mode of administration. Absolute bioavailability was determined from the ratio of the areas under the serum concentration curves obtained after oral and intravenous administration of equal doses. Bioavailability was also estimated by analysis of variance. The results indicated absolute availability of the three products of 39–54%. One of the products, a capsule formulation, showed a significantly lower bioavailability than the others, which were tablet formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558335
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  • 17
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of indoprofen in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 257-262 
    Details
    ISSN: 1432-1041
    Keywords: Anti-inflammatory and analgesic drug ; indoprofen ; pharmacokinetics ; bioavailability ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a pharmacokinetic study of the new analgesic and anti-inflammatory drug indoprofen, plasma levels and urinary excretion were determined in four healthy volunteers after 100 mg and 200 mg iv, and after 100 mg (capsules) and 200 mg (tablets) oral doses. After iv administration, the mean biological half-life (t1/2 β) was about 2 h (range 1.4 to 3.2 h). The apparent volume of distribution Vdβ ranged between 11 to 17 % of body weight, indicating its limited extravascular distribution. Most of the drug was excreted in urine as glucuronide and a smaller proportion as unchanged indoprofen: the 24 h urinary excretion of these compounds accounted for 67 to 95 % of an iv dose. Peak plasma levels occurred between 30 and 120 minutes after oral administration of 100 mg as capsules or 200 mg as tablets. The mean biological half-life was about 2 h, as after iv administration. The bioavailability of oral doses was assessed using both plasma levels and urinary excretion data. The absorption of capsules and tablets was practically complete, that of the former being faster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558338
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  • 18
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of butobarbital after single and multiple oral doses in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 263-271 
    Details
    ISSN: 1432-1041
    Keywords: Butobarbital ; pharmacokinetics ; plasma concentration ; oral administration ; accumulation ; enzyme induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A method is described for the assay of therapeutic levels of butobarbital (5-ethyl-5-n-butylbarbituric acid) in human plasma, which involves a single extraction step followed by gas chromatography with alkali flame ionization detection. The pharmacokinetics of butobarbital were studied in five healthy volunteers after oral administration of 200 mg. Plasma concentrations were determined at regular intervals up to 96 h and the data were fitted by non-linear, least squares regression analysis according to one-compartment kinetics. The average lag time was 0.11 h and the absorption half-life 0.21 h. The elimination half-life varied from 33.6 to 41.5 h with an average of 37.5 h. Four of the volunteers participated in a study of multiple dosing (every 24 h) during which substantial accumulation of butobarbital was observed. The elimination half-life after termination of drug administration had decreased to about 20–25% of its initial value, probably because of enzyme induction. It was concluded that butobarbital could not be regarded as a suitable drug for treatment of insomnia, since CNS depressant effects were likely to persist into the following day. Repeated administration of butobarbital should be avoided and its incidental use restricted to patients who require day-time sedation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558339
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  • 19
    Electronic Resource
    Electronic Resource
    A GLC assay for bendroflumethiazide. Preliminary data about its plasma level in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 293-295 
    Details
    ISSN: 1432-1041
    Keywords: Bendroflumethiazide ; diuretics ; GLC ; thiazides ; plasma level ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A GLC method for determination of bendroflumethiazide has been developed, using extractive methylation. Cyclopenthiazide was used as internal standard. The maximal plasma concentration (56–107 ng/ml) after bendroflumethiazide 10 mg given orally to four healthy volunteers was seen at 2–2.5 h. On the slope between 4 and 10 h T1/2 averaged 2.7 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558343
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  • 20
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of amitriptyline infused intravenously in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 337-341 
    Details
    ISSN: 1432-1041
    Keywords: Amitriptyline ; pharmacokinetics ; intravenous infusion ; two compartment model ; biological half-life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Amitriptyline was given to four male volunteers by constant rate intravenous infusion. Blood samples were collected before, during and at various times after the infusion for estimation of the serum concentrations of amitriptyline. The level of nortriptyline never reached a detectable level. A two compartment open model was shown to be applicable to the data obtained. The meaning of the parameters obtained by a non-linear, least squares curve fitting procedure is discussed and the values are compared to those recently published for nortriptyline. The calculated biological half-life of amitriptyline was about 17 hours, a figure which differs considerably from previously calculated values for volunteers, but is in accordance with some newer results from patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565623
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  • 21
    Electronic Resource
    Electronic Resource
    Postoperative disappearance of phenazone from plasma in man (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 63-68 
    Details
    ISSN: 1432-1041
    Keywords: Phenazone ; pharmacokinetics ; injuries ; surgery ; operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The elimination rate of phenazone after a single oral dose has been studied before and after elective operations. In a group of patients with different illnesses the elimination rate was increased on the fourth to seventh days after operation but was unchanged on the second and third days. The change in elimination rate was highly significant in a standardized group of nine patients with a ligament injury in one knee studied on the fourth or fifth postoperative day. Possible reasons for the changes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561552
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  • 22
    Electronic Resource
    Electronic Resource
    Clinical pharmacokinetics of sisomicin: Two-compartment model analysis of serum data after I.V. and I.M. administration (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 251-256 
    Details
    ISSN: 1432-1041
    Keywords: Sisomicin ; pharmacokinetics ; bioavailability ; two-compartment analysis ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of sisomicin, a new single component aminoglycoside antibiotic related to gentamicin c1a, were determined in four healthy volunteers after intravenous and intramuscular administration of a 1 mg/kg dose. The elimination profile of this antibiotic follows two-compartment model kinetics after I.V. administration. The fast (α) and slow (β) disposition rate constants averaged 0.072 and 0.004 min−1, respectively. The volume of distribution at the steady-state averaged 0.185 liters/kg which approximately corresponds to the volume of extracellular space. The physiological availability of an intramuscular dose appeared to be complete. A method of administration adapted to the kinetic properties of the drug is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558337
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  • 23
    Electronic Resource
    Electronic Resource
    Studies on hydralazine (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 183-187 
    Details
    ISSN: 1432-1041
    Keywords: Hydralazine ; bioavailability ; pharmacogenetics ; first pass effect ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary After oral administration of a single 50 mg dose of hydralazine (Apresoline®), the serum half-life (T1/2) and bioavailability (AUC0−∞) were assessed in 16 healthy volunteers. The half-life was 2.57±0.14 h (S.E.) in 10 slow acetylators of sulphadimidine, and 2.18±0.15 h in 6 fast acetylators (difference not statistically significant). AUC0−∞ was significantly higher in slow acetylators, at 1.04±0.10 µg·hour·ml−1, compared to 0.66±0.12 µg·hour·ml−1 in the fast acetylators (p〈0.025). Treatment with Apresoline® 25 mg tid produced minimum serum concentrations at steady-state of 57.3±7.3 ng·ml−1 and 33.4±4.2 ng·ml−1 in 8 slow and 5 fast acetylators, respectively (p〈0.05). The corresponding maximum concentrations were 228.8±20.3 ng·ml−1 and 147.6±15.0 ng·ml−1 in slow and fast acetylators, respectively (p〈0.025). First-pass metabolism of hydralazine could explain the difference in bioavailability of the drug between fast and slow acetylators, without any corresponding difference in the elimination rate of the drug in the post-distributive phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558327
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  • 24
    Electronic Resource
    Electronic Resource
    Comparison of the pharmacokinetics of diazepam after single and subchronic doses (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 121-126 
    Details
    ISSN: 1432-1041
    Keywords: Diazepam ; pharmacokinetics ; subchronic dosage in man ; desmethyldiazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In seven healthy male volunteers the effects of the pattern of dosing on the pharmacokinetics of diazepam have been studied. A cross-over design was employed that consisted of three parts: a single intravenous dose (0.1 mg/kg), and oral dosing (10 mg/day) for six days followed by an intravenous bolus (0.1 mg/kg) on the seventh day, followed by re-examination of a single intravenous dose after diazepam (D) and its major metabolite desmethyldiazepam (DD) had been completely eliminated. Plasma levels of D and DD were monitored by a specific, sensitive GLC-method. In younger patients (n=5, age 29 – 35 years) the elimination half-life, T1/2 (β), of D was 33.9±10.6 h (mean±S.D.) after the single dose. The control study gave an almost identical result (35.7±12.1). After subchronic dosage in all patients T1/2 (β) showed a modest but significant prolongation (paired t-test p〈0.01) to 52.9±17.4 h. It was caused by a significant decrease (p=0.016) in total plasma clearance ( $$\overline {\user1{Cl}} $$ ), from 26.0±10.8 ml/min to 18.2±7.0 ml/min. Older patients (age 43–60 years) showed the same phenomenon. Blood/plasma ratios remained constant indicating no change in protein binding. Biliary excretion of D was measured in five patients with a T-tube. Only negligible amounts (0.3–0.4%) of administered D were excreted within 3 days after subchronic dosage, which demonstrates a lack of enterohepatic cycling of D. After multiple administration of D, there was accumulation of DD to levels approximately five times higher than after a single dose. The possibility that the slower elimination of D after subchronic treatment might be caused by DD was also supported by experiments in dogs and rabbits. After pretreating rabbits with DD and maintaining a high DD plasma level, there was prolongation of T1/2 (β) from 2.7 h to 5.2 h, with a corresponding decrease of $$\overline {\user1{Cl}} $$ from 101.6 ml/min to 23.4 ml/min. Similar results were obtained in dogs. It is concluded that the disposition of D is altered by subchronic use and may be regulated by the plasma DD concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609470
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  • 25
    Electronic Resource
    Electronic Resource
    Studies on hydralazine (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 311-317 
    Details
    ISSN: 1432-1041
    Keywords: Hydralazine ; instability of impaired renal function ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Following a single 50 mg dose of hydralazine (Apresoline®) in 13 patients with impaired renal function, a decrease in glomerular filtration rate (GFR) was correlated with an increase in serum half-life (T1/2) of the drug (r=−0.69; p〈0.01). The T1/2 was 15.8 h in one patient with a GFR of 16 ml·min−1, as compared to a T1/2 of 1.7–3.0 h found previously in 16 healthy volunteers. In 49 patients on long-term antihypertensive treatment with hydralazine, the ratio between the minimum steady-state drug concentration and the daily dose of hydralazine (C SS min : Dose) increased as the GFR decreased. This accumulation of the drug was particularly evident in patients with a GFR less than 30 ml·min−1 (r=−0.63; p〈0.01; n=19). As renal excretion of unchanged hydralazine is generally regarded as unimportant, the slower elimination rate in chronic renal failure was probably caused by a slower rate of metabolic conversion. It was found, however, that the renal excretion of hydralazine could easily have been underestimated, as only 12.7% of an initial hydralazine concentration of 200 ng·ml−1 in urine could be recovered after storage of the samples at room temperature for 24 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565619
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  • 26
    Electronic Resource
    Electronic Resource
    Influence of sex on the clinical pharmacology of flutiorex, a new anorectic drug (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 325-330 
    Details
    ISSN: 1432-1041
    Keywords: Flutiorex ; pharmacokinetics ; sex ; anorectic agent ; sympathetic stimulation ; CNS stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of flutiorex, a new anorectic agent, and of a placebo on food intake and the activity of the sympathetic and central nervous systems have been compared in a double blind trial in two groups of healthy volunteers, one of five males and the other of five females. Flutiorex 20 mg orally had a significant anorectic effect both in males and females, the observed reduction in food intake being 34.0 and 27.5%, respectively. It caused α-adrenergic stimulation (blood pressure and pupil diameter) and central nervous system excitation (critical flicker frequency), both of which were more marked in males than in females. Flutiorex was better tolerated by women than by men. Measurement of the blood level of flutiorex and its de-ethylated metabolite, norflutiorex, showed that both compounds were detectable in four of the five male subjects, but in only one of the five females. Sex-linked differences in the pharmacokinetics of flutiorex may explain the greater intensity of its effects in males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565621
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  • 27
    Electronic Resource
    Electronic Resource
    Serum concentrations of methaqualone after repeated oral doses of a combination formulation to human subjects (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 343-347 
    Details
    ISSN: 1432-1041
    Keywords: Methaqualone ; hypnotic ; pharmacokinetics ; combination formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Concentrations of methaqualone have been measured in the serum of five male human subjects receiving five consecutive evening doses of a combination formulation containing methaqualone (250 mg), carbromal (300 mg) and benactyzine (0.33 mg) in each tablet. After administration of the first dose, mean peak serum concentrations of methaqualone (1.2 µg/ml) occurred at 3 h. After obtaining peak levels, mean concentrations of methaqualone declined rapidly during the next 6 h and there-after more slowly during the next 18 h. After administration of the last (fifth) dose, mean peak serum concentrations of methaqualone (1.9 µg/ml; 1.5 µg/ml above the predose level) occurred at 2 h. After attaining peak levels, mean concentrations of methaqualone declined rapidly during the next 6 h, and thereafter more slowly, with a half-life of approximately 10 h. Mean concentrations of methaqualone in serum samples 24 h after the second, third, fourth or fifth doses were not significantly different (0.3 µg/ml – 0.6 µg/ml) during this period of dosing. This suggests that significant accumulation of methaqualone in the serum did not occur during a period of five consecutive evening doses of the combination formulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00565624
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  • 28
    Electronic Resource
    Electronic Resource
    Effect of exchange transfusion on the elimination of digoxin in neonates (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 25-29 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; exchange transfusion ; pharmacokinetics ; neonates ; 86Rb assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary By means of an86Rb-uptake inhibition assay, changes in the plasma concentration of digoxin and the amount of the glycoside removed during exchange transfusion have been studied in two newborns. For comparison, the exchange procedure was simulated by a computer on the basis of a two-compartment open model and available pharmacokinetic constants. A rapid decrease in plasma digoxin concentration during exchange transfusion was found when the glycoside was administered intravenously or intramuscularly within 60 min before the procedure. The amount of digoxin removed by the exchange was less than 6 per cent of the given dose. Computer simulation of the procedure also showed removal of only a minor amount of digoxin. It is concluded that the decrease in plasma concentration and the removal of only a small amount of glycoside by the exchange transfusion can be attributed mainly to extensive tissue distribution of digoxin. The results imply that replacement of digoxin after an exchange transfusion seems unnecessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561545
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  • 29
    Electronic Resource
    Electronic Resource
    The influence of hypoglycaemic sulphonylureas on elimination and efficacy of phenprocoumon following a single oral dose in diabetic patients (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 31-36 
    Details
    ISSN: 1432-1041
    Keywords: Diabetes mellitus ; drug interaction ; phenprocoumon ; pharmacokinetics ; pharmacodynamics ; sulphonylureas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of various antidiabetic treatments on the kinetics and efficacy of a single oral dose of 12 mg phenprocoumon were studied in 71 hospitalized patients, 58 with adult-onset diabetes mellitus and 13 non-diabetic aged patients, and 13 healthy young volunteers. Treatment for one week or longer with insulin or the antidiabetic sulphonylureas tolbutamide, glibenclamide or glibornuride, altered neither the plasma level (1.29 – 1.40 µg/ml at zero time) nor the half-life of phenprocoumon (5.2 – 6.8 d) compared to treatment by diet alone. The mean half-life of phenprocoumon was significantly shorter in non-diabetic aged patients (4.2 d) than in diabetic patients of the same age (5.1 – 6.8 d), or in young healthy volunteers (5.7 d). The efficacy of a single dose of phenprocoumon (maximal reduction of Quick-values by 34 – 47% after 48 to 72 hrs) in diabetic patients treated with diet, or diet and antidiabetic drugs, was the same as in non-diabetic aged patients. In healthy young volunteers phenprocoumon was half as effective as in aged patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561546
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  • 30
    Electronic Resource
    Electronic Resource
    Comparison of the half-life of antipyrine in plasma, whole blood and saliva of man (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 327-332 
    Details
    ISSN: 1432-1041
    Keywords: Antipyrine ; pharmacokinetics ; half-life ; blood ; plasma ; saliva ; individual variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A previously described GLC method has been modified and applied to measurement of antipyrine levels in plasma, blood and saliva of man following administration of a single oral dose (10 mg/kg). The levels in blood and saliva were comparable to those in plasma at every time studied. The half life of antipyrine determined in blood, plasma or saliva in any given individual was similar. The intersubject variation in half-life was about two-fold (n=5). Antipyrine levels in saliva were not affected by the rate of saliva flow when collections were made continuously for 20 minutes. This study has demonstrated that kinetic data about antipyrine comparable to that from plasma may also be obtained from readily accessible tissue fluids, such as saliva and capillary blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561668
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  • 31
    Electronic Resource
    Electronic Resource
    Interindividual differences in chlorthalidone concentration in plasma and red cells of man after single and multiple doses (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 319-325 
    Details
    ISSN: 1432-1041
    Keywords: Chlorthalidone ; diuretics ; drug plasma concentration ; protein binding ; red blood-cell concentration ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A gas chromatographic method has been employed to determine chlorthalidone in plasma and whole blood after therapeutic doses. Radioactively labelled chlorthalidone was used for in vitro studies of the uptake of chlorthalidone from plasma by red blood cells. Chlorthalidone was markedly concentrated in red cells and as a compartment they would account for at least 30% of total drug in the body after multiple doses. The ratio between the plasma and red cell concentration of chlorthalidone varied between individuals. After a single oral dose of 50 mg in 6 healthy volunteers chlorthalidone was eliminated with a half-life of 51 to 89 hours. The apparent volume of distribution varied between 3 and 13 1/kg and the clearance between 53 and 145 ml/min. The mean steady-state plasma concentrations during treatment with a standard dose of 50 mg daily (n=10) varied 5-fold between individuals. During the steady state approximately 50% of the daily dose was excreted unchanged in the urine during 24 hrs. The plasma levels observed in patients were higher than those predicted from the single oral dose studies in healthy volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561667
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  • 32
    Electronic Resource
    Electronic Resource
    Observations on the efficacy and pharmacokinetics of sotalol after oral administration (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 367-372 
    Details
    ISSN: 1432-1041
    Keywords: Sotalol ; β-adrenoceptor blocking drugs ; exercise tachycardia ; efficacy ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of sotalol after oral administration were measured on the tachycardia induced by strenuous exercise in normal subjects. Plasma sotalol levels were also determined. The oral administration of sotalol (50, 100, 200 and 400 mg) to 6 subjects produced a progressive reduction in the tachycardia induced by severe exercise. This was similar to the effects of 25, 50, 100, 200, 400 and 800 mg given to different subjects. Each increase in sotalol dose produced a successively greater reduction in exercise tachycardia. This did not appear to be maximum even with 800 mg. Oral sotalol was rapidly absorbed and produced peak blood levels in 2 – 3 hours. The plasma levels of sotalol measured 2 hours after the oral administration of 25 to 800 mg showed never more than a six-fold variation between different subjects. The half-life of sotalol in plasma was 12.7 ± SE 1.6 hours. There was a significant correlation between the logarithm of the plasma sotalol concentration and the percentage reduction of exercise heart rate. It is concluded that the oral administration of sotalol either once or twice daily (depending on dose level) will provide satisfactory 24-hour blockade of β-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606550
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  • 33
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 443-450 
    Details
    ISSN: 1432-1041
    Keywords: Cyclobarbital calcium ; pharmacokinetics ; plasma concentration ; relative bioavailability ; oral administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and relative bioavailability of cyclobarbital calcium have been studied after oral administration of Phanodorm, of tablets according to the Formularium Nederlandse Apothekers (1968; FNA), and an aqueous solution. Six healthy volunteers participated in the investigation on three occasions and each received the three preparations. The dose administered was 300 mg cyclobarbital calcium. Plasma concentrations of cyclobarbital were determined at regular intervals. Absorption from the three preparations was rapid and was faster from the solution. Peak concentrations were usually attained within 1 h. The elimination of cyclobarbital could be described by a single first-order process with an average half-life of 11.6 h (range 8 – 17 h). There was little intra-subject variation of the half-life. Relative bioavailability for each volunteer was estimated by comparing the areas under the plasma concentration curves. The FNA-tablets and Phanodorm exhibited similar bioavailability, whereas the average bioavailability of the solution was 78% of that of FNA-tablets; the reason for this unexpected finding is unknown. It was concluded that cyclobarbital cannot be regarded as a uniformly suitable drug for the treatment of insomnia. The long half-life that was apparent in some of the volunteers (15 – 17 h) creates a substantial risk of residual effects on the following morning. In principle, however, the calcium salt of cyclobarbital may be used for induction of sleep, because of its rapid absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606563
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  • 34
    Electronic Resource
    Electronic Resource
    Penetration of Phytophthora cinnamomi into disease tolerant and susceptible eucalypts (1976)
    Springer
    Archives of microbiology 108 (1976), S. 231-242 
    Details
    ISSN: 1432-072X
    Keywords: Phytophthora ; Penetration ; Eucalypts ; Roots ; Electron microscopy ; Appressoria ; Plugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The mechanisms of penetration of Phytophthora cinnamomi Rands into seedling eucalypt roots were studied by light and electron microscopy. Culture grown seedlings of root-rot tolerant Eucalyptus st johnii and root-rot susceptible Eucalyptus obliqua were inoculated with both zoospores and mycelium. Zoospores encysted on roots of both species and the germ tubes penetrated without the formation of appressoria. Swellings, previously described as appressoria, were formed when the germ tube was slow to enter the host by intracellular penetration. Vegetative hyphae penetrated both inter- and intracellularly into the zones of root elongation and differentiation, often through root hairs. Evidence of hydrolysis of the host cell-wall at the point of penetration was observed in electron micrographs. Several hours after the germ tube penetrated the epidermis, a thick plug of amorphous material formed in the germ tube slightly below the level of the outer walls of the epidermal cells, sealing off the hypha within the root. Behaviour of zoospores and germ tubes and the mechanism of penetration were similar on both hosts. Micrographs do not suggest any kind of a hypersensitive reaction by the host cells during the early stages of infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454847
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  • 35
    Electronic Resource
    Electronic Resource
    Physiology and fine structure of sporangiospore germination in Piptocephalis unispora prior to infection (1976)
    Springer
    Archives of microbiology 107 (1976), S. 99-107 
    Details
    ISSN: 1432-072X
    Keywords: Piptocephalis unispora ; Mucorales ; Kickxellaceae ; Electron microscopy ; Germination ; Spore swelling ; Sporangiospore
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Germination of the sporangiospore of Piptocephalis unispora Benjamin, observed by means of light and electron microscopy, involved the formation of a new inner wall which became continous with the inner layer of the wall of the germ tube. The outer wall layer of the germ tube was continous with the original inner wall layer of the dormant spore. Preliminary details of appressorium structure were noted. Nutritional experiments indicated that sporangiospores required external sources of utilisable nitrogen and carbon compounds for maximal swelling and germ tube production. Limited development occurred when either nutrient was supplied singly. Comparison of germination of the asexual spore with that in other Mucorales, especially the Kickxellaceae, has been made, and the merosporangial status in P. unispora discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427874
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  • 36
    Electronic Resource
    Electronic Resource
    Microfilament bundles in antheridial nuclei of Achlya ambisexualis E 87 (1976)
    Springer
    Archives of microbiology 107 (1976), S. 113-114 
    Details
    ISSN: 1432-072X
    Keywords: Achlya ; Electron microscopy ; Nuclear microfilaments ; Antheridia ; Mycology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This is the first report of intranuclear microfilaments within gametangial nuclei of oömycetous fungi. Longitudinal sections of four to six microfilaments were frequently observed in meiotic antheridial nuclei of Achlya ambisexualis. Each microfilament measured approximately 7–10 nm in diameter. Spindle tubules (25 nm in diameter) were also observed within some of the nuclei possessing microfilaments.
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    URL: http://dx.doi.org/10.1007/BF00427876
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  • 37
    Electronic Resource
    Electronic Resource
    Structure and composition of intracytoplasmic membranes of Ectothiorhodospira mobilis (1976)
    Springer
    Archives of microbiology 107 (1976), S. 167-182 
    Details
    ISSN: 1432-072X
    Keywords: Ectothiorhodospira mobilis ; Photosynthetic membranes ; Electron microscopy ; Isolation of membranes ; Structure of membranes ; Composition of membranes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The lamellar membrane stacks of Ectothiorhodospira mobilis were isolated and purified by a combination of lysozyme and osmotic shock treatment, followed by differential and density gradient centrifugation. Preparations of lamellar membranes were enriched at least 2.4-fold in the ratio of bacteriochlorophyll a to protein. Thin-sectioning, negative staining, platinumcarbon shadowing and freeze-etching were used to study the architecture of the membrane units. Both platinum-carbon shadowing and freeze-etching showed the outer surfaces of the isolated lamellar membrane stacks to be relatively smooth. Particles averaging 7 nm in diameter were seen on several faces following freeze-ctching. Non-polar amino acids amounted to 60% of the total amino acid composition. Lipids constituted 32% of the membrane dry weight. Phosphatidyl ethanolamine and diphosphatidyl glycerol were the major phospholipids. Fatty acids of 10–15 carbons represented a small fraction of both membrane and whole cell fatty acids. Monoenes constituted 36% of the total membrane fatty acids and 38.4% of the total whole cell fatty acids. The major fatty acids of both whole cells and purified membranes were C16:0, C18:1 and cyclopropane C19:0.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446836
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    Electronic Resource
    Electron microscopy of isolated cell walls of Bacillus subtilis var. niger (1976)
    Springer
    Archives of microbiology 109 (1976), S. 195-197 
    Details
    ISSN: 1432-072X
    Keywords: Cell wall ; Peptidoglycan ; Electron microscopy ; Bacillus subtilis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Isolated cell walls of Bacillus subtilis have a striated appearance in the electron microscope. The structure persists when teichoic acids are removed. It is inferred that the structure bears on the arrangement of the peptidoglycan chains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425135
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  • 39
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    Electronic Resource
    The fine structure of Micrococcus radiophilus and Micrococcus radioproteolyticus (1976)
    Springer
    Archives of microbiology 107 (1976), S. 313-320 
    Details
    ISSN: 1432-072X
    Keywords: Micrococcus radiophilus ; Micrococcus radioproteolyticus ; Bacterial cell walls ; Fine structure ; Electron microscopy ; Taxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The radiation resistant bacteria Micrococcus radiophilus and M. radioproteolyticus were studied by thin sectioning and freeze-etching techniques and the two species were found to be similar in the fine structure. The only significant difference was in the appearance of the surfaces of the cell walls in freeze-etched preparations. Since the two species, together with M. radiodurans, possess a unique cell wall structure and a cell wall peptidoglycan, which is different from that of other micrococci and Gram-positive cocci, it is recommended that they be reclassified into a new genus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425346
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  • 40
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    Electronic Resource
    Alterations in the cell wall of Spirillum serpens VHL early in its association with Bdellovibrio bacteriovorus 109D (1976)
    Springer
    Archives of microbiology 108 (1976), S. 55-64 
    Details
    ISSN: 1432-072X
    Keywords: Bdellovibrio ; Spirillum ; Cell wall ; Bdelloplast ; Lipoprotein ; Peptidoglycan ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In both freeze-etched and critical-point dried preparations examined by transmission and scanning electron microscopy, respectively, the outer surfaces of the cells of Spirillum serpens VHL assume a wrinkled appearance 10–15 min after challenge by Bdellovibrion bacteriovorus 109D. This wrinkling effect is believed (on circumstantial evidence) to be caused by the bdellovibrio's disruption of the cell wall lipoprotein of the Spirillum. With the exception of those topological changes caused by wrinkling, the outer membrane of the Spirillum cell wall retains a normal appearance as viewed in freeze-etched preparations, even after the Spirillum cell has been converted into a bdelloplast. Although the peptidoglycan layer of the Spirillum cell presumably is weakened somewhat by the invading Bdellovibrio, evidence obtained from freeze-fractured preparations of Spirillum bdelloplasts suggests that the peptidoglycan remains as a discrete cell wall layer, even though the Spirillum cell wall apparently has lost much of its rigidity. That the peptidoglycan backbone remains essentially intact, even after the Spirillum cell has been entered by the Bdellovibrio, is supported by the observation that the soluble amino sugar content of the culture medium, as determined by chemical analysis, does not rise even 5.0 h after the association of the Bdellovibrio with the Spirillum has begun.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425093
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  • 41
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    Electronic Resource
    The cytology of the gametes and fertilization of Allomyces macrogynus (1976)
    Springer
    Archives of microbiology 109 (1976), S. 21-30 
    Details
    ISSN: 1432-072X
    Keywords: Electron microscopy ; Allomyces ; Gametes ; Fertilization ; Membrane fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The gametes and the process of fertilization were examined by light and electron microscopy in the lower eukaryote Allomyces macrogynus. Differences in gamete morphology included the overall larger size and the presence of a larger nuclear apparatus, along with the association of a side-body complex and many more mitochondria in the female gamete. In this species of Allomyces, fertilization was initiated by contact and fusion of specialized regions of the gamete plasma membranes resulting in a binucleate fusion cell surrounded by plasma membrane contributed by both partners. Following plasmogamy, nuclear fusion was initiated by multiple nuclear membrane contacts between adjacent outer membranes. Following inner membrane fusion, small nucleoplasmic bridges were observed which presumably fused with one another and resulted in a single bridge which widened, forming the mature diploid nucleus. After karyogamy, fusion of the nuclear caps did not always occur and zygotes with and without fused caps were observed. Coalescence of the nucleoli completed the events of fertilization, forming a zygote with a single nuclear apparatus (sometimes with two caps) and two flagella. These observations are discussed in relation to fertilization mechanisms and compared to fertilization in other organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425108
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  • 42
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    Electronic Resource
    Ultrastructural study of testis in testicular feminization (1976)
    Springer
    Archives of gynecology and obstetrics 221 (1976), S. 277-287 
    Details
    ISSN: 1432-0711
    Keywords: Electron microscopy ; Endocrinology ; Pathology ; Testicular feminization ; Testis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Testicular tissue was investigated by electron microscopy in a case of testicular feminization. The seminiferous tubules were lined by spermatogonia and by Sertoli cells. Spermatocytic maturation was not observed. Leydig cells were numerous and contained well developed, abundant vesicular smooth-surfaced endoplasmic reticulum and large mitochondria with tubulovesicular cristae. Reinke crystalloids were absent. The ultrastructural findings were consistent with the assumption that Leydig cells were under adequate stimulation and were in a stage of active secretion. Hence, the results seem to indicate that testicular endocrine function was maintained in the studied case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00667021
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  • 43
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    Electronic Resource
    Ultrastructure of Lewy bodies in the stellate ganglion (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 183-197 
    Details
    ISSN: 1432-0533
    Keywords: Lewy body ; Electron microscopy ; Parkinsonism ; Dense core vesicles ; Catecholamines ; Mitochondrial inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Lewy body, a characteristic nerve cell inclusion in idiopathic parkinsonism, was examined by electron microscopy in the stellate ganglion, obtained from 9 patients at autopsy. Three main forms of Lewy bodies or Lewy body-related structures were demonstrated: A. Rare filamentous Lewy bodies, similar to Lewy bodies in the central nervous system. B. Granular Lewy bodies in nerve cell processes. C. Abnormal nerve cell processes, filled with heterogenous material. Large dense core vesicles were prominent in the last 2 forms. None of these abnormalities were found in 2 control groups consisting of 9 parkinsonism cases without central nervous system Lewy bodies, and 17 cases without parkinsonism. The filamentous Lewy body (type A) was found in the perikaryon and was surrounded by neuromelanin, whereas the other forms (type B and C) were seen in nerve cell processes. Mitochondrial inclusions, present mainly, but not exclusively, in neuromelanin-containing cells, were not related to Lewy body formation or to parkinsonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688674
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  • 44
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    Electronic Resource
    In vitro characteristics of a sacrococcygeal chordoma maintained in tissue and organ culture systems (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 13-25 
    Details
    ISSN: 1432-0533
    Keywords: Chordoma ; Tissue and organ culture ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Explants of a human sacral chordoma were successfully maintained on collagen-coated coverslips, gelfoam sponge matrices, and Millipore filter platforms for up to 30 days. Tumor cells cultured on collagen-coated coverslips became increasingly vacuolated whereas those maintained in organ culture were entirely free of vacuoles after 22 days in vitro. A single basic tumor cell, small and polygonal with a large central spherical nucleus and abundant endoplasmic reticulum and Golgi apparatus, was recognized. Vacuoles were formed as the result of the progressive expansion of smooth endoplasmic reticulum. Coalescence of these vacuoles produced the physaliferous cell of light microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688940
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  • 45
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    Electronic Resource
    Esthésioneurocytome olfactif (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 139-150 
    Details
    ISSN: 1432-0533
    Keywords: Electron microscopy ; Olfactory esthesioneurocytoma ; Neurosecretory granules ; Microtubules ; Dystrophic axons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One case of malignant tumour of the left nasal cavity is reported in a woman 56 year old, affected by the disease 24 years. Numerous recurrences appeared and various histological diagnoses were performed. At the last surgery, the tumour invaded the ethmoïd and was a typical olfactory esthesio-neurocytoma. By electron microscopy, mature ganglion cells with dense cored vesicles (neurosecretory granules) were densely packed. Neuritic processes with microtubules were rarely normal in size and their content was most often abnormal; furthermore dystrophic axons were noted in great number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690560
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  • 46
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    Electronic Resource
    Light and electron microscopic investigations on a transplantable tumour of the rat, induced by transplacental administration of ENU (ethylnitrosourea) (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 177-184 
    Details
    ISSN: 1432-0533
    Keywords: Neurinoma ; ENU ; Prenatal carcinogenesis ; Transplantability ; Metastases ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With a single dose of 80 mg/kg ENU, a tumour originating from the trigeminal nerve was induced transplacentally in the offspring of a Sprague-Dawley rat. The neoplasm diagnosed as a neurinoma, was transplanted over 20 passages to 5 six-month-old Sprague-Dawley rats in each case. During this time, the biological behaviour of the tumour as well as its histological appearance were followed. Ultrastructural observations were made of the 20th passage. The tumour caused multiple metastases in the lung and in the lymph nodes of the neck in 30 animals. Recurrences were formed within a week, metastases of the lung appeared from then on in all cases. During the time of transplantation, the neurinoma dedifferentiated histologically so markedly that it was no longer possible to classify the neoplasm as a neurogenous tumour after 20 passages. Ultrastructurally, poorly differentiated Schwann cells could nervetheless be recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685279
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  • 47
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    Electronic Resource
    “PKU Bodies”: Characteristic inclusions in the brain in phenylketonuria (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 295-305 
    Details
    ISSN: 1432-0533
    Keywords: PKU bodies ; Demyelination ; Dysmyelination ; Neuroglia ; Inborn errors of metabolism ; Phenylketonuria ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of various inclusions within oligodendroglial cells in the brains from two phenylketonuric patients was studied. Characteristic lamellar, oval, slightly irregular inclusions measured between 0.5 and 2 micra in diameter and were bounded by a single membrane. The longitudinal and transverse lamellae of these inclusions had a distinct pattern. In analogy to lamellated but different inclusions of other diseases, these structures were termed “PKU bodies”. Various possibilities that would explain the morphogenesis of the PKU bodies and other inclusions in the oligodendroglial cells, and the significance of these findings, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00699635
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  • 48
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    Electronic Resource
    Morphological differences between the atrophied small muscle fibres in amyotrophic lateral sclerosis and Werdnig-Hoffmann disease (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 321-327 
    Details
    ISSN: 1432-0533
    Keywords: Muscle fibres ; Amyotrophic lateral sclerosis ; Werdnig-Hoffmann disease ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle biopsies from 5 cases of Werdnig-Hoffmann disease and 4 cases of ALS were investigated by histology and electronmicroscopy. The differences in morphology found in the atrophic muscle fibres in ALS and in W.H. diesease consisted mainly in the shape and structure of their cells and the number of the nuclei. Atrophic muscle fibres irregular in shape and size with degenerative changes and accumulated nuclei observed in ALS were markedly different from the picture of the fibres in W.H. disease. The presence of small muscle cells uniform diameter with well preserved architecture and single nuclei and numerous myotube-like cells seem to indicate a foetal defect in children with W.H. disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696561
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  • 49
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    Renflement fusiforme d'origine mécanique d'un nerf périphérique. Étude anatomique (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 47-54 
    Details
    ISSN: 1432-0533
    Keywords: Entrapment neuropathy ; Fusiform nerve enlargement ; Segmental demyelination ; Axonal changes ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper reports on the study of a symptomless fusiform enlargement of the superficial peroneal nerve. The swelling was located in the part of the nerve passing through the aponevrosis. On incision of the epineurium small swellings were seen in the nerve fascicles. A fascicular biopsy was done and the fascicles studied by teasing and by optic and electron microscopy. Isolated nerve fiber study gave evidence of segmental demyelinisation with subsequent remyelinisation in almost all the myelinated fibers. These abnormalities were only encountered in the swollen part of the fascicle. A striking proliferation of cells was demonstrated in isolated fibers by counter-staining with hematoxylin. Electron microscopy showed primary demyelinsation and cellular proliferation affecting Schwann-cells (without onion bulb formations), fibroblasts and giant-vacuolated histiocytes. There was also a massive increase of endoneurial fluid. A few Büngner bands were seen. These rare abnormalities appear to be caused by chronic irritation of the nerve in its passage through the aponebrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688942
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  • 50
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    Electronic Resource
    Damage of skeletal muscle in rats by immunoglobulins (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 207-218 
    Details
    ISSN: 1432-0533
    Keywords: Immunomyopathy ; Muscle disease ; Electron microscopy ; Experimental muscle pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An experimental model of the autoimmune process was developed to study the ultrastructural aspects of immunomyopathies. Every type of muscle fibre organelle was affected and the severity of injury increased in direct proportion to time following immunization. It is suggested that ultrastructural methods are useful in studies concerned with the analysis of structural aspects of experimental immunomyopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688676
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  • 51
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    Electronic Resource
    Development of onion bulb neuropathy in the Trembler mouse (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 137-152 
    Details
    ISSN: 1432-0533
    Keywords: Trembler mouse ; Peripheral neuropathy ; Electron microscopy ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Trembler mouse is a neurological mutant showing dominant inheritance. The peripheral nerves show a delay in myelination, segmental demyelination and the development of an onion bulb neuropathy. Using electron microscopy a comparative morphometric study of nerve fibres in the sciatic nerve in normal and Trembler mice was made. The animals ranged in age from 3 days to adult. The following features were noted: 1. Mean axon diameters of the Trembler mice were smaller than normal at all ages. 2. Myelination was delayed and myelin was thinner than normal in the Trembler mice. 3. The ratio of myelin thickness to axon diameter was reduced in Trembler mice. 4. There were no significant quantitative or qualitative differences observed between middle and distal levels of Trembler nerves. The balance of evidence from these findings and the previous morphological studies is in keeping with the suggestion that the primary lesion resides in the Schwann cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685276
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  • 52
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    Electronic Resource
    Sequence of morphological alterations in the nervous system of metachromatic leucodystrophy (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 369-379 
    Details
    ISSN: 1432-0533
    Keywords: Leukodystrophy, metachromatic ; Prenatal diagnosis ; Sulphatide accumulation ; Myelination, central, peripheral ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light and electronmicroscopic findings are reported in a case of metachromatic leukodystrophy diagnosed prenatally who died after iatrogenic abortion during the 23th week of gestation. The brain of this foetus was not yet myelinated while the spinal cord showed early, and the peripheral nerves advanced myelination. The onset and the degree of myelination were similar as in a normal foetus of the same age. Ultrastructurally there was evidence of sulphatide storage before the beginning of myelination. During myelination lysosomal storage material, staining metachromatically in acid cresyl violet preparations, appeared in oligodendrocytes and Schwann cells. Besides sulphatide storage material, prominent amounts of neutral lipids were found in oligodendrocytes. Myelin breakdown was encountered very seldom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00699642
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  • 53
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    Electronic Resource
    Studies on experimental malignant nerve sheath tumors maintained in tissue and organ culture systems (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 27-45 
    Details
    ISSN: 1432-0533
    Keywords: Experimental malignant Schwannomas ; Melanin and melanogenesis ; Tissue and organ culture ; Electron microscopy ; Pigmented nerve sheath tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four melanin pigment-containing intracranial tumors were found in three Long-Evans rats in the course of experimental oncogenesis by transplacental ethylnitrosourea (ENU). One of them was a leptomeningeal melanoma. Aside from the presence of scattered melanin-pigmented cells, the other three had the typical histological features of ENU-induced malignant nerve sheath tumors. Two of the three tumors were studied by electron microscopy and in tissue and organ culture systems. One of them demonstrated progressive melanogenesis in vitro; the other failed to produce more melanin and showed increasing differentiation, with a Schwannoma-like pattern by light microscopy. Melanosomes and premelanosomes were identified in both tumors by electron microscopy; the other fine structural features were those of malignant Schwannomas. These observations are relevant to the controversy on the histogenesis of pigmented nerve sheath tumors occasionally encountered in man and on the relationship of these tumors to pigmented nevi. The findings in the present study support the view of Masson that neoplastic nerve sheath cells are capable of melanogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688941
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  • 54
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    Electronic Resource
    Ultrastructure of the Gunn rat substantia nigra I. Cytoplasmic changes (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 93-107 
    Details
    ISSN: 1432-0533
    Keywords: Substantia nigra ; Gunn rat ; Complex membranous bodies ; Bilirubin ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The substantia nigra of various aged hyperbilirubinemic (Gunn) rats was studied by means of electron microscopy. The cytological features observed in the neuronal somata were the presence of (1) complex membranous bodies (CMBs), (2) dilated cisternae of granular endoplasmic reticulum, (3) single membrane bound vacuoles and (4) enlarged mitochondria. Nearly every neuronal soma studied in two week old Gunn rats contained CMBs, which consisted of several layers of membrane that usually, but not always, surrounded small islands of cytoplasm. On occasion CMBs were seen to be directly connected with granular endoplasmic reticulum and, in a few instances, they were located within a cistern of endoplasmic reticulum. There were significantly fewer CMBs in the neuronal somata of adult Gunn rats. They were located peripherally in the somata or in the proximal portions of dendrites. Furthermore, in these animals the cytoplasm appeared normal and did not exhibit the features commonly seen in younger animals. Only a few hyperchromatic neurons were observed and no pronounced gliosis was evident. Therefore it is assumed that the majority of substantia nigra neurons recovered from the toxic effect of bilirubin or that the concentration of bilirubin deposited in the substantia nigra is not sufficient to be lethal. The hypothesis that is considered is that CMBs represent autophagic activity which results from exposure of neurons to bilirubin. The adjacent neurites and glia did not demonstrate the cytoplasmic changes that were characteristic of the neuronal somata.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690556
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  • 55
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    Electronic Resource
    Whipple's disease of the central nervous system (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 31-38 
    Details
    ISSN: 1432-0533
    Keywords: Whipple's disease ; Central nervous system ; Granulomatous infiltration ; Electron microscopy ; Bacillary bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Whipple's disease presenting as a neurological disease without gastrointestinal symptoms is an unusual occurrence. A 40 year old man suffered hypersomnia, memory loss and progressive ophthalmoplegia for 6 months prior to death. The nature of his disease was not established during life. Extensive granulomatous inflammation affecting the hypothalamus, hippocampus and periaqueductal gray matter of the brain was found to represent Whipple's disease by electron microscopy. Characteristic lesions were also present in spleen, mesenteric lymph nodes, small intestine and myocardium. Bacillary bodies and membranous inclusions similar to those seen in visceral lesions of Whipple's disease were present in macrophages. The findings supported the theory of direct involvement of the central nervous system by bacilli rather than a metabolic origin for the lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685145
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  • 56
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    Electronic Resource
    Dynamic aspects of peripheral nerve changes in progressive neural muscular atrophy (1976)
    Springer
    Journal of neurology 211 (1976), S. 111-124 
    Details
    ISSN: 1432-1459
    Keywords: Peripheral nerve ; Peroneal muscular atrophy ; Nerve biopsy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2 Patienten mit progressiver neuraler Muskelatrophie wurden Nervenbiopsien jeweils in einem frühen und in einem fortgeschrittenerem Stadium der Erkrankung entnommen und verglichen. In beiden Fällen zeigten bereits die frühen Biopsien ein völliges Fehlen der großkalibrigen, dickbemarkten Axone. Ebenfalls als frühe Veränderung wurde eine Erweiterung des endoneuralen Interstitiums festgestellt. Eine geringe Anzahl der vorhandenen bemarkten und unbemarkten Axone in allen Biopsien wies degenerative Veränderungen auf. Die für die progressive neurale Muskelatrophie typische Zwiebelschalenbildung der Schwannschen Zellen — möglicherweise eine Reaktion auf wiederholte De-und Remyelinisierungsvorgänge um dystrophische Axone — trat erst in den späteren Biopsien deutlicher hervor. Hinsichtlich der formalen Genese der hypertrophischen Neuropathie bei neuraler Muskelatrophie sind nach diesen Beobachtungen axonale Dystrophie und interstitielle Veränderungen des Endoneuriums als primäre Entmarkung und Zwiebelschalenbildung als sekundäre Phänomene zu betrachten. Die Möglichkeit einer kausalen Beziehung zwischen axonaler Dystrophie und interstitiellen Veränderungen wird an Hand der vorliegenden Befunde und Literatur diskutiert.
    Notes: Summary Serial nerve biopsies were performed at an early, and at an advanced stage of the disease in 2 patients with progressive neural muscular atrophy. The early biopsy showed a complete loss of the large diameter and thickly myelinated fibres, as well as an expansion of the endoneurial interstitium in both cases. Myelinated and unmyelinated fibres exhibited axonal degeneration in all biopsies occasionally. “Onion bulb” formation, a typical feature of peripheral neuropathy in neural muscular atrophy, was found to be prominent only in the latter biopsies. As regards the formal pathogenesis of hypertrophic neuropathy in neural muscular atrophy, axonal dystrophy and interstitial changes of the endoneurium were regarded as primary phenomena, demyelination and “onion bulb” formation as secondary. A possible causal relation between axonal dystrophy and interstitial changes, observed in these cases, is discussed in the light of the present literature.
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    URL: http://dx.doi.org/10.1007/BF00313355
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    Zur Morphologie und Bedeutung des Mononukleären-Phagozyten-Systems (MPS) bei der chronischen Rhinosinusitis (1976)
    Springer
    European archives of oto-rhino-laryngology and head & neck 214 (1976), S. 27-48 
    Details
    ISSN: 1434-4726
    Keywords: Mononuclear Phagocytic System (MPS) ; Macrophages ; Rhinosinusitis ; Immunology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neither the concept of the Reticulo-Endothelial-System (RES) Aschoff's (1924) nor that of the Reticulo-Histiocyte-System (RHS) provides a satisfactory framework into which the present knowledge of the phagocytic mononuclear cells can be fitted. Current knowledge concerning morphology, histochemistry (peroxydase and esterase activity), immunology (specific surface antigens, receptors on the cell membranes), function (immune phagocytosis, pinocytosis), kinetics (3H-thymidine labelling) and culture makes it possible to place all highly phagocytic mononuclear cells and their precursors in one system, which is called the Mononuclear-Phagocytic-System (MPS) (Langevoort, Conn, Hirsch, Humphrey, Spector, van Furth, 1969). Kinetic studies with labelled cells have shown, that mononuclear phagocytes originate from precursor cells in the bone marrow (stem cell → monoblasts → promonocytes), than are circulating in the peripheral blood as monocytes and are transformed to tissue macrophages entering tissues. The MPS comprises following cells in following organs: connective tissue (histiocytes resp. macrophages); liver (Kupffer-cells); lung (alveolar macrophages); lymph nodes (free and fixed macrophages); bone marrow (macrophages); serous cavities (pleural and peritoneal macrophages); bone tissue (osteoclasts?); nervous system (microglial cells) (see Table 1). The reticular cells, endothelial cells and fibroblasts (fibrocytes) can therefore not be included in the MPS. Besides differences in morphology, histochemistry and function, they derive from mesenchymal cells and not from the bone marrow as the MPS. The present investigation demonstrates the structure and significance of the MPS in various kinds of chronic-specific and non-specific rhinosinusitis. On semithin sections two kinds of macrophages can be distinguished light-microscopically: 1. Larger macrophages with many phagosomes (storage cells) (Fig. 1A), which can exhibit sometimes a ring-shape on sections embracing greater parts of the interstitium (Fig. 1B). Such forms are mainly found in chronic (maxillary) sinusitis and are interpretated as “scavenger” macrophages. 2. The second type consists of smaller macrophages with extremely ruffling of the cell surface, wich is interpretated as an expression of highly (specific?) stimulated states. These later macrophages can be seen mainly in edematous nasal polyps, which might be caused by allergic reactions of the anaphylactic type. The fine structure of the phagocytes is to some extend dependent on the actual development and functional state: there are “immature” macrophages, which are practically indistinguishable from blood monocytes (Fig. 2A); some of them can be stimulated and can therefore show many surface foldings and projections (Fig. 2B). The “mature” macrophage shows a well developped Golgi-area and many secondary lysosomes (Fig. 3). The storage type of the macrophages, which can predominate in some cases of chronic maxillary sinusitis, is characterized by many electron-lucent vacuoles (Fig. 4). The macrophages can transform unspecifically to epitheloid- and giant-cells, as it is shown in foreign bodys- and cholesterol-granulomas in maxillary sinusitis (Fig. 5A and 5B). This tranformation to epitheloid and giant-cells might also be induced specifically by stimulated T-lymphocytes in immunological reaction of the delayed type, for example in sarcoidosis (Fig. 6A) and tuberculosis (Fig. 6B) of the nose. The macrophage is not only of great importance as the carrier of the cellular immunity in the sense of Metschnikoff (1905), but he is also involved in the initiation and regulation of the specific humoral and cellular immune responses. These facts and the phagocytic and synthetic properties of the macrophages are discussed in regard to their significance for the etiology and course of chronic rhinosinusitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455107
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    Time sequence and site of fluid accumulation in experimental neurogenic pulmonary edema (1976)
    Springer
    Research in experimental medicine 168 (1976), S. 219-227 
    Details
    ISSN: 1433-8580
    Keywords: Initial phase of neurogenic pulmonary edema ; Perfusion fixation ; HRP ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The initial phase of pulmonary edema development following intracranial pressure elevation was studied by means of transmission electron microscopy. Using perfusion fixation and application of a blood tracer (HRP horseradish peroxidase) the time sequence and site of fluid leakage out of pulmonary vessels was demonstrated: - passage of edema fluid through intercellular clefts of alveolar capillary endothelium - edema accumulation in alveolar interstitial tissue - draining of edema fluid from the alveolar septum to the interstitium of terminal bronchioli and to lymphatic vessels. An early interepithelial fluid leakage out of the alveolar wall remains questionable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851320
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  • 59
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    Pharmacokinetics of the antiarrhythmic disopyramide in healthy humans (1976)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 199-230 
    Details
    ISSN: 1573-8744
    Keywords: disopyramide ; antiarrhythmic ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of the antiarrhythmic disopyramide, 4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide phosphate, and its monodealkylated metabolite were investigated in seven volunteers after intravenous (1 and 2 mg/kg) and oral (3 and 6 mg/kg) administration. Unchanged drug (52%) and the monodealkylated metabolite (25%) were renally excreted on intravenous administration. The pharmacokinetics of disopyramide were first order and dose independent only when referenced to the drug not bound to plasma proteins since this binding was dose dependent. The apparent half-lives of the α and β phases on intravenous administration were 2 min and 4.5 hr, respectively. The apparent volumes of distribution of the central and peripheral compartments, referenced to unbound disopyramide in the plasma, were 9 and 80 liters, respectively. The half-life of absorption of oral aqueous disopyramide phosphate was 30 min with a lag time of 16 min and an apparent first-pass metabolism of 16% of the absorbed dose, consistent with the hepatic efficiency of 14%. The renal and metabolic clearances were 125 and 111 ml/min, respectively. Graphical and computer analysis of the plasma and urine data showed dose-independent first-order pharmacokinetics of plasma unbound drug in a two-compartment-body model to give two metabolites and a first-pass transformation of a fraction of the oral dose. The absorption efficiency of unchanged drug was 83%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01063614
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    Theoretical and computational basis for drug bioavailability determinations using pharmacological data. I. General considerations and procedures (1976)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 337-353 
    Details
    ISSN: 1573-8744
    Keywords: bioavailability ; pharmacological data ; pharmacokinetics ; modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The use of data deriving from monitoring the time variation of the intensity of pharmacological effect(s) following dosing can often present an advantageous alternative to the more conventional approach of using chemical or radiological assay of blood and/or urine level data for bioavailability evaluations of drug products: bioavailability studies can be performed with drugs where no assay exists. A relatively simplified discussion of the general theoretical principles on which the use of pharmacological data is based and a stepwise description of the approach for its routine application in bioavailability studies are presented. Approaches for computing rates and extents of drug bioavailability vs. time profiles on analog and digital computers are qualitatively described and quantitatively presented in a subsequent report. The concept of preabsorption (gastrointestinal bioavailability) is introduced and biophasic availability of drugs to local sites of action is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01063123
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  • 61
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    Theoretical and computational basis for drug bioavailability determinations using pharmacological data. II. Drug input ⇄ response relationships (1976)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 355-375 
    Details
    ISSN: 1573-8744
    Keywords: deconvolution ; bioavailability ; pharmacokinetics ; modeling ; pharmacological data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Mathematical expressions and approaches to the computation of rates and extents of drug bioavailability for implementation on analog and digital computers are derived. The equivalency of expressions derived on the basis of assuming compartment models to an approach based on using experimentally determined weighting functions is demonstrated. The relative merits of the two techniques are discussed: their application for use with temporal pharmacological data is emphasized. The applicability of the computational techniques to determining the availability of drugs at local sites of action (biophasic availability) and to computing preabsorptive drug release into the gastrointestinal contents (gastrointestinal bioavailability) is pointed out. An approach to computationally predicting in vivo blood level or pharmacological response vs. time profiles from in vitro dissolution testing results is presented and its limitations are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01063124
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  • 62
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    Effect of peripheral axotomy on the fine structure and histochemistry of the Rolando substance: Degenerative atrophy of central processes of pseudounipolar cells (1976)
    Springer
    Experimental brain research 26 (1976), S. 73-87 
    Details
    ISSN: 1432-1106
    Keywords: Rolando substance ; Degeneration ; Atrophy ; Axotomy ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Disappearence of fluorid-resistant acid phosphatase activity from the ipsilateral Rolando substance after transection of the peripheral nerve, is shown to be due to the cessation of enzyme supply from dorsal root ganglion cells to their central terminals. This is accompanied by (or ensues in consequence of) a fine structural derangement of these terminals (“degenerative atrophy”). Fine structural alterations of axon terminals undergoing degenerative atrophy, though similar to some extent to those seen during early phases of a Wallerian degeneration, are markedly different. Also myelinated nerve fibers, both in the dorsal horn and in dorsal columns, are affected by degenerative atrophy. This important, new trophical feature of sensory ganglion cells suggests a delicate metabolic balance between peripheral and central axonal branches of bipolar (pseudounipolar) cells. Degenerative atrophy raises serious implications in evaluating hodological experiments based upon Wallerian degeneration and offers new perspectives for theoretical and clinical neurology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235250
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    On the fungitoxicity of some new thiocyanatopyrazole derivatives: Electron microscopical study in trichophyton mentagrophytes (1976)
    Springer
    Mycopathologia 58 (1976), S. 39-47 
    Details
    ISSN: 1573-0832
    Keywords: Trichophyton mentagrophytes ; Thiocyanatopyrazole derivatives ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Four thiocyanatopyrazole derivatives were synthesized and their fungistatic activity was demonstrated in vitro against a number of dermatophytic fungi. In Trichophyton mentagrophytes, the most active compound induced an unusual increase of the plasma membrane with production of intra and extracytoplasmic complexes, a deterioration of nuclear and mitochondrial membranes and a formation of autophagic-like vacuoles. Plasmolysis, accompanied by an almost complete disorganization of cytoplasmic structures, seemed to be the final event. A possible mechanism of action of the compounds was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493592
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  • 64
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    Electronic Resource
    Changes in the fine structure of venous endothelium in the rabbit following adrenaline infusion (1976)
    Springer
    Cell & tissue research 169 (1976), S. 123-128 
    Details
    ISSN: 1432-0878
    Keywords: Venous endothelium ; Adrenaline infusion ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of the endothelium lining the femoral and mesenteric veins in the rabbit was examined following the infusion of concentrations of adrenaline varying from 0.5 to 5.0 μg/kg. Control animals were infused with saline. Vesiculation of the endothelial cells was observed following each infusion of adrenaline, the effect being most marked with the highest dose used. It is suggested that this vesiculation may be associated with the release of antihaemophilic globulin and/or plasminogen activator from the endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219312
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  • 65
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    The ultrastructure of the cell types in the endocrine pancreas of the horse (1976)
    Springer
    Cell & tissue research 167 (1976), S. 179-195 
    Details
    ISSN: 1432-0878
    Keywords: Islets of Langerhans ; Horse pancreas ; Cell types ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Das Inselorgan der Bauchspeicheldrüse des Pferdes wurde an immersions- und perfusionsfixiertem Material untersucht. Dabei ließen sich nach der Immersions- wie Perfusionsfixation fünf Zelltypen unterscheiden: 1. A-Zellen, die im Zentrum der Insel liegen, 2. B-zellen, die hauptsächlich blasse Granula enthalten und den größten Teil der Inselperipherie ausmachen, 3. D-Zellen, die ebenfalls vorwiegend in der Inselperipherie liegen, 4. G-Zellen, die am Rand der Inseln und im exokrinen Pankreas anzutreffen sind, 5. S-Zellen (“small granule cells”), die relativ selten und nur in den Inseln zu finden sind. Über die Funktion und altersabhängigen Veränderungen dieser Zellen wird diskutiert. Die Bildung von hellen und dunklen Zellen halten wir für ein Artefakt, ebenso die Bildung von sog. Mischzellen, da diese Zelltypen nur nach Immersionsfixation auftreten.
    Notes: Summary The islets of Langerhans of the equine pancreas were examined with the electron microscope after immersion or perfusion fixation. Five cell types could be distinguished after fixation by either technique: 1. A-cells, situated at the center of the islets, 2. B-cells, containing mostly “pale granules” and constituting the principal cell type of the periphery of the islets, 3. D-cells, also located mainly at the periphery of the islets, 4. G-cells, found at the edge of the islets and in the exocrine pancreas, and 5. S-cells, (small granule cells), which are relatively few in number and occur only in the islets. The function and age-dependent modifications of these cells are discussed. The formation of light and dark cells and of “mixed cells” are regarded as artifact, since cells of this type occur only under the condition of immersion fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224326
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    The postnatal development of myelinated nerve fibres in the visual cortex of the cat (1976)
    Springer
    Cell & tissue research 167 (1976), S. 265-288 
    Details
    ISSN: 1432-0878
    Keywords: Myelinated fibres ; Visual cortex ; Stereology ; Development ; Electron microscopy ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary With the aid of stereological procedures the development of myelinated nerve fibres (MF) was quantitatively investigated in electron micrographs of the visual cortex from animals of different ages: 36 days-old, the age at which fibres first appear, through adulthood. A short description of tissue treatment, methods and qualitative results is given. The following quantitative results are presented: 1. Myelinization begins at about the 36th day postpartum and is not completed by the 164th day. At this time a lack of about 20% MF can be observed. 2. The average diameter of MF decreases from 1.3 μm to 0.8 μm from day 36 to adulthood. 3. The first MF appear near the border of the album. 4. Beginning with the 55th day, small MF arise in layer I, showing two periods of growth. 5. The maximum MF density in the region of layer IV corresponds to the strip of Baillarger. Other aspects of visual cortex development are dealt with in the Discussion. The following conclusions can be drawn: a) The growing of inand output-MF is completed first. b) The development of the internal connecting systems in layers I and IV begins a little later and is completed by the 5th month. c) The MF in layers II and III appear after the 4th month. Kaes (1907) has also described a continuation of MF growth in man lasting into the twenties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224332
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    Fine structure of taste buds in the barbel of the catfish, Ictalurus punctatus (1976)
    Springer
    Cell & tissue research 169 (1976), S. 395-403 
    Details
    ISSN: 1432-0878
    Keywords: Taste buds ; Fishes ; Electron microscopy ; Nucleolus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Taste buds occur in the epithelium of the catfish barbel along its entire length. Two major cell types, light and dark cells, occupy the upper two-thirds of the taste bud. A third cell type, the basal cell, lies on the basal lamina and is essentially separated from the light and dark cells by a plexus of unmyelinated nerve fibers. The dark cells have branching processes, both apically and basally whereas the light cells have a single apical process and many basal processes. The apical processes of dark cells contain secretory granules, while the apical processes of light cells contain an abundant agranular endoplasmic reticulum. Light cell nuclei contain bundles of 10 nm filaments, often arranged in the shape of a cup or ring, but nucleoli are rarely seen. It is suggested that this morphology indicates a low degree of RNA synthesis by light cells. The basal cells contain large numbers of vesicles, about 60 nm in diameter, which are sometimes seen in clumps in relation to an adjacent nerve fiber in a configuration resembling a synapse. Curiously, although basal cells present a large surface to the basal lamina, there are no hemidesmosomes. This suggests that the basal cell does not originate from the epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219610
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    Ultrastructure of perfusion-fixed fetal capillaries in the human placenta (1976)
    Springer
    Cell & tissue research 172 (1976), S. 157-169 
    Details
    ISSN: 1432-0878
    Keywords: Placenta (Human) ; Capillaries ; Tight junctions ; Electron microscopy ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ultrastructure of human placental capillaries was investigated using perfusion fixation and the freeze-fracturing technique. The capillaries have a continuous endothelium especially rich in microfilaments, whereas micropinocytotic vesicles are exceedingly scarce. The endothelial cells are connected by three types of junctions: (1) zonulae occludentes characterized by 2 to 4 focal regions of membrane contact in thin-sectioned specimens and an equal number of ridges on the membrane E-face in freeze-fractured specimens; (2) small gap junctions associated with the zonula occludens. (3) attachment plaques resembling zonulae adhaerentes in their fine structure. Endothelial cells are provided with long, circularly oriented pseudopodial extensions, which may be responsible for intermittent constrictions of the vessel lumen. These findings indicate that diaplacental transport at the level of the fetal capillary is controlled by the cytoplasm of the endothelial cells and probably occurs only to a very limited extent by way of micropinocytotic vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226024
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  • 69
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    The morphology and innervation of subepithelial “striated” muscle cells in the male guinea-pig urethra (1976)
    Springer
    Cell & tissue research 174 (1976), S. 281-288 
    Details
    ISSN: 1432-0878
    Keywords: Striated muscle ; Guinea-pig urethra ; Innervation ; Morphology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Light and electron microscopic techniques have been used to determine the distribution, morphology and innervation of subepithelial striated muscle cells in the wall of the proximal urethra of the male guinea-pig. These cells form a continuous layer, immediately beneath the urethral epithelium extending from the bladder neck to the termination of the ejaculatory ducts into the proximal urethra. They differ from “typical” striated muscle fibres (as seen in the external urethral sphincter) by their small size, rich acetylcholinesterase content and the irregular arrangement of intracellular myofilaments and sarcoplasmic reticulum. In addition, motor end plate regions have not been observed on these striated cells when examined using a light microscopic histochemical technique. The cells are related to acetylcholinesterase positive nerves which run between them in a manner compatible with the occurrence of “en passant” synaptic interactions. Using electron microscopy, axonal varicosities containing small (50 nm diameter) agranular vesicles are encountered 50 nm from the striated cells; membrane specialisations characteristic of motor end plates have not been observed on the cells. The findings are discussed, particularly in relation to the distribution, unusual morphology and innervation of these subepithelial muscle cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222165
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    Three muscle fibre types in the axial muscle of axolotl (Ambystoma mexicanum Shaw) A quantitative lightand electron microscopic study (1976)
    Springer
    Cell & tissue research 168 (1976), S. 65-78 
    Details
    ISSN: 1432-0878
    Keywords: Muscle fibre types ; Axolotl (Ambystoma mexkanum) ; Morphometry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Morphometric analysis by light microscopy of p-phenylene-diamine stained semithin sections of axolotl tail muscle revealed differences in the cross-sectional area of the fibres and in the number of mitochondria and of lipid inclusions per fibre, and indicated the presence of three distinct types of fibres. The tripartition was found to be statistically highly significant. Representative fibres from each group established by light microscopic morphometry were subjected to an ultrastructural morphometric analysis. The volume content of mitochondria amounted to 9.8% of the fibre volume for red, 4.0% for intermediate and 0.8% for white fibres. The myofibrils composed 60%, 70% and 83% in the same fibres. The volume of the sarcotubular system (t-tubuli and sarcoplasmic reticulum) was 2.5% in red, 4.5% in intermediate and 11.7% in white fibres. The three fibre types also demonstrated differences in myofibrillar cross-striation pattern and number of triads. The reliability of the light microscopic morphometry was tested by correlation with EM montages of the representative fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219724
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    Relationship between the chromatoid body and the acrosomal system in early spermatids of Myxine glutinosa L. (1976)
    Springer
    Cell & tissue research 174 (1976), S. 427-430 
    Details
    ISSN: 1432-0878
    Keywords: Chromatoid body ; Acrosome ; Electron microscopy ; Myxine glutinosa L.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Eine vorübergehende enge Beziehung zwischen dem Chromatoiden Körper und dem sich entwickelnden Acrosom wird in jungen Spermatiden von Myxine glutinosa demonstriert.
    Notes: Summary A transient close relationship between the chromatoid body and the developing acrosome is demonstrated in early spermatids of Myxine glutinosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220685
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  • 72
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    Differential sensitivity of rods and cones in Xenopus retina to hemicholinium-3 (1976)
    Springer
    Cell & tissue research 175 (1976), S. 59-72 
    Details
    ISSN: 1432-0878
    Keywords: Retina ; Xenopus ; Rods ; Cones ; Hemicholinium-3 ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Hemicholinium-3 (HC-3), a drug which prevents synthesis of acetylcholine in neurons, when injected intraperitoneally in doses as low as 2×5 mg/kg produces marked ultrastructural changes and damage in rod but not in cone photoreceptors. In rods it causes a reduction in cytoplasmic back-ground density, swelling of the endoplasmic reticulum, ballooning of the outer membrane of the nucleus, leaching of the nucleoplasm and clumping of the nuclear chromatin. In dark-adapted rods HC-3 produces some loss of cytoplasmic synaptic vesicles but no reduction in numbers of those vesicles which lie adjacent to the synaptic ribbons. In light-adapted rods the drug does not cause such an apparent reduction of synaptic vesicles but does induce a considerable reduction in numbers of vesicles associated with the ribbons. These structural changes are discussed in the light of what is known about the pharmacology of HC-3 and neurotransmitter release from vertebrate photoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220823
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  • 73
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    Morphology and location of dense-core vesicles in the stomatogastric ganglion of the lobster, Panulirus interruptus (1976)
    Springer
    Cell & tissue research 175 (1976), S. 369-390 
    Details
    ISSN: 1432-0878
    Keywords: Electron microscopy ; Crustacea ; Synaptic vesicles ; Biogenic amines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The appearance and distribution of dense-core vesicles in the stomatogastric ganglion of the spiny lobster, Panulirus interruptus, were examined using transmission electron microscopy. Following five fixation techniques, three types of dense-core vesicles were identified on the basis of size and morphology. Type-I vesicles are found in a distinct neuronal fiber system that appears to be involved in chemical transmission within the ganglion. Type-II vesicles occur in nerve processes in the ganglion, in major nerve trunks and in the perineural sheath of the nerves and ganglion. Type-III vesicles are present in all neuronal somata of the ganglion. The distinct morphology and location of the three types of vesicles suggest that their functional roles differ. Furthermore, the histochemical, biochemical and physiological data available for the Stomatogastric ganglion indicate that Type-I vesicles may store dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218716
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    Dedication (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 1-1 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070102
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  • 75
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    Prüfung von Flanschverbindungen in GFK-Rohrleitungen NW 200 durch Kurz- und Langzeitbeanspruchung - Teil I: DichtverhaltenHerrn Dir. Dr.-Ing. Kurt Richard zum 65. Geburtstag gewidmet (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 12-23 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Testing of flanged joints in GRP pipelines of 200 mm nominal diameter by means of short-term and long-term stressing. Part I: Sealing behaviour. The first part of this report deals with the sealing behaviour of joints with fixed and loose flanges in GRP pipelines of 200 mm nominal diameter. Tests were made with seven different flanges from three manufacturers and four different types of sealing rings. At room temperature the spring rate of the GRP flanges amounted to between 8% and 18% of that of welded steel flanges and at a temperature of 80°C within the pipe it was 5% to 16% of that of the steel flanges. Of the sealing rings tested a bulged soft rubber ring with steel reinforcement was found to have the flattest resilience characteristic and required the least bolt force to produce a tight joint under operational conditions. Its relaxation rate was low after low bolt force had been applied and increased rapidly when the initial bolt force was increased to higher values. Because of their lower spring rates, the GRP flanges sealed with this ring required 2.5 to 3.5 times as much initial bolt force as welded steel flanges. In an 1100-hour creep test at 80°C internal temperature and 10 bar internal pressure, a joint consisting of loose steel flanges and GRP shoulders exhibited considerably less loss of initial force than a fixed GRP flanged joint. Because losses of initial force increase at a disproportionately high rate as the force is raised, high initial force would not seem to increase remarkably the reliability of the seal in the long term. Since rigid flanges require less initial force than less rigid ones, high spring rate appears desirable. Apparently it could best be achieved by loose steel flanges with GRP shoulders. The results of the strength tests will be presented in the second part of this report.
    Notes: Der erste Teil dieser Arbeit befaßt sich mit dem Dichtverhalten von GFK-Fest- und -Losflanschen NW 200 dreier Hersteller sowie von vier verschiedenen Dichtungen. Die Federrate der GFK-Flansche betrug bei Raumtemperatur 8% bis 18% und bei 80°C Innentemperatur 5% bis 16% der Federrate von Vorschweißflanschen aus Stahl. Von den untersuchten Dichtungen hatte eine ballige Weichgummidichtung mit Stahleinlage die flachste Kennlinie und benötigte die niedrigste Betriebsdichtungskraft. Ihre Relaxationsgeschwindigkeit war bei niedrigen Dichtungskräften gering und nahm bei höheren Kräften stark zu. Die GFK-Flansche erforderten wegen ihrer geringeren Federrate mit dieser Dichtung eine 2,5- bis 3,5mal höhere Vorspannkraft als Stahl-Vorschweißflansche. In einem 1100-h-Zeitstandversuch bei 80°C Innentemperatur und 10 bar Innendruck des Prüfkörpers hatte eine GFK-Losflanschverbindung mit Stahlringen wesentlich geringere Vorspannungsverluste als eine GFK-Festflanschverbindung. Wegen der mit der Dichtungskraft überproportional steigenden Vorspannungsverluste dürften hohe Vorspannkräfte die Sicherheit gegen Leckwerden auf Dauer wenig erhöhen. Da steife Flansche eine geringere Vorspannung als weniger steife benötigen, erscheint eine hohe Federrate erstrebenswert. Sie dürfte sich am ehesten bei Losflanschen aus Stahl mit GFK-Bunden erreichen lassen. Die Ergebnisse der Festigkeitsuntersuchungen werden im zweiten Teil dieser Arbeit mitgeteilt.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070105
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  • 76
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    Electronic Resource
    Identifikation röntgenographischer Pulverdiagramme mit dem TischcomputerHerrn Dir. Dr.-Ing. Kurt Richard zum 65. Geburtstag gewidmet (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 38-48 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Identification of X-Ray powder diffraction patterns with the mini-computer. A description is given of a programme for identifying X-ray diffraction patterns of multiphase, polycrystalline materials with the minicomputer Wang 720 C. It is determined by the identification strategy, the identification criterion and the Δd(d) function which describes the permissible variation between the measured d values and those laid down in accordance with ASTM material data cards in the magnetic tape file. In the course of these investigations the partially erroneous and often also incomplete information provided by this file in respect of relevant material data proved in particular to be the decisive factor for the limitation of the reliability of the identification result.The efficiency of the programme is demonstrated by means of characteristic examples. In conclusion, the prospects for the future development of this programme are discussed.
    Notes: Es wird ein Programm zur Identifikation von Röntgenbeugungsdiagrammen mehrphasiger, polykristalliner Stoffe mit dem Tischcomputer Wang 720 C beschrieben. Seine bestimmenden Größen sind die Identifikationsstrategie, das Identifikationskriterium und die Δd(d)-Funktion, die die zulässige Abweichung zwischen den gemessenen und den in der Magnetband-Datei nach ASTM-Stoffdatenkarten festgelegten d-Werten vorgibt. Im Verlauf dieser Untersuchungen erwiesen sich insbesondere die z. T. fehlerhaften und nicht selten auch unvollständigen Angaben dieser Kartei bei relevanten Stoffdaten als der entscheidende Faktor für die Begrenzung der Zuverlässigkeit des Identifikationsergebnisses.An charakteristischen Beispielen wird die Leistungsfähigkeit des Programms demonstriert. Abschließend wird ein Ausblick auf die Weiterentwicklung dieses Programms gegeben.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070108
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  • 77
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    Metallphysik. Von G. E. R. Schulze. 2. überarbeitete Auflage, Springer-Verlag, Wien, New York 1974, 480 Seiten, 277 Bilder, Gebunden 98,-DM (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 123-123 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070309
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  • 78
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    Moderne Verfahren der Oberflächenanalyse. Von Dechema, Deutsche Gesellschaft für chemisches Apparatewesen e. V. Dechema-Monographien, Band 78, Nr. 1537-1548. 1. Auflage, Verlag Chemie GmbH, Weinheim/Bergstraße. 1975, 297 Seiten, zahlr Bilder zahlr. Iabellen, DIN A 5, Ln. Preis DM 57,75 für Mitglieder der DECHEMA, DM 72,20 für Nichtmitglieder (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 123-123 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070311
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  • 79
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    Die Phosphatierung von Metallen. Von Werner Rausch und Mitarbeitern. Eugen G. Leutze Verlag, Saulgau/Württ. 1. Auflage, 1974. 344 Seiten, 137 Bilder, 105 Tabellen (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 123-123 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070313
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  • 80
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    Electronic Resource
    High Temperature Materials in Gas Turbines. Von P. R. Sahm und M. O. Speidel. 1. Auflage, Elsevier Scientific Publishing Company, Amsterdam. 1974, 388 Seiten, zahlreiche Bilder. Ln. 38,50 U$ (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 123-123 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070314
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  • 81
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    Grundlagen des Festigkeits-und Bruchverhaltens. Von W. Dahl, Aachen. 1. Auflage, Verlag Stahleisen m.b.H., 4 Düsseldorf 1, 1974, 284 Seiten, 465 Bilder, 12 Tafeln, DIN A4, 88,-DM (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 124-124 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070317
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  • 82
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    Electronic Resource
    Veranstaltungshinweise (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. A67 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070410
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  • 83
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    Untersuchungen über gestaltungsbedingte Einflüsse auf die BauteilzähigkeitHerrn Dir. Dr.-Ing. Kurt Richard zum 65. Geburtstag gewidmet (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 2-7 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Tests on influence of shape to structural member toughness. Supplementary to former work on temperature depending toughness of boiler plate and low temperature steel vessels, influences of shape and manufacturing are investigated with model vessels of a different design, made of boiler plate. The expected influences seem to be evident only with regard to bursting behaviour of the vessels depending on temperature, whilst toughness behaviour may be estimated - without dependence on shape - by materials property data (crack arrest temperature and impact transition temperature).
    Notes: Ergänzend zu früheren Arbeiten über die temperaturabhängige Zähigkeit von Modellbehältern aus Kesselblech und aus Tieftemperaturstahl werden hier an Behältern anderer Konstruktionsform aus Kesselblech zusätzlich Einflüsse der Gestaltung und der Fertigung untersucht. Dabei zeigt sich, daß diese Einflüsse sich offenbar nur auf die Haltbarkeit der Behälter und den Verlauf des Berstdrucks über der Temperatur auswirken, daß aber die Verformungsreserve und damit das Zähigkeitsverhalten unabhängig davon aufgrund von Werkstoffkennwerten (Rißauffangtemperatur und Kerbschlagübergangstemperatur) abgeschätzt werden kann.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070103
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  • 84
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    Diskussion: Kompaktverbundwerkstoff und Schicht-Grundwerkstoff-Verbundsysteme (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 314-315 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070905
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  • 85
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    Mechanische Verträglichkeit bei VerbundwerkstoffenDer Fachausschuß „Verbundwerkstoffe“ der Deutschen Gesellschaft für Metallkunde hat zu Beginn der Tagung „Verbundwerkstoffe“ in Konstanz (31. März bis 2. April 1976) im Rahmen einer separaten Diskussionsveranstaltung den Themenkreis „Mechanische Verträglichkeit bei Verbundwerkstoffen“ behandelt. Mit diesem Workshop wurde das Ziel angestrebt, Probleme der mechanischen Verträglichkeit aus verschiedenen Blickrichtungen zu beleuchten, zukünftige Forschungs- und Entwicklungsarbeiten anzuregen und Wissenschaftlern und Technikern einen Überblick über dieses Gebiet der Materialforschung zu geben (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 305-306 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: The Mechanical Compatibility of Composite Components. The mechanical interactions between the components of a composite material are governed by the elastic constants, the strength and the plastic deformation behavior of the components. They can be furthermore influenced by the coefficients of thermal expansion and by the bond strength between the components. The extent of mechanical compatibility depends on the structure of the composite material and on its processing technique and practical application. This paper gives an introduction to a series of papers on the mechanical compatibility presented in a workshop meeting at Konstanz.
    Notes: Die Mechanische Verträglichkeit bewertet das Verhalten von Materialkomponenten in einem Verbundsystem. Die mechanischen Wechselwirkungen bei Verbundwerkstoffen werden einerseits durch die elastischen Konstanten, die Festigkeit und das plastische Formänderungsvermögen der einzelnen Komponenten bestimmt und andererseits durch Unterschiede in den thermischen Ausdehnungskoeffizienten und durch die Haftfestigkeit zwischen den Komponenten festgelegt. Bei der Beurteilung der mechanischen Verträglichkeit spielt die Art des Verbundwerkstoffs und der äußeren Beanspruchung eine wesentliche Rolle. Diese Arbeit gibt eine Einführung in die Probleme der mechanischen Verträglichkeit, die in einem Workshop der Deutschen Gesellschaft für Metallkunde in den Themenkreisen Grundlagen, Meßmethoden und Beeinflussung des Werkstoffverhaltens ausführlich behandelt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070902
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  • 86
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    Electronic Resource
    Bemerkungen zur Frage der mechanischen Verträglichkeit von Verbundwerkstoffen (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 316-316 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070906
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  • 87
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    Electronic Resource
    Diskussion: Spannungsanalyse und Methode der finiten Elemente (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 323-325 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070909
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  • 88
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    Electronic Resource
    Diskussion: Dilatometrie und mechanische Meßmethoden (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 332-333 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070912
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  • 89
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    Electronic Resource
    Mechanische Verträglichkeit von Schichtverbundstoffen im Hochtemperatur-Korrosionsfall (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 338-340 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070915
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  • 90
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    Mechanische Verträglichkeit bei Verbundwerkstoffen - Naßkorrosion (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 340-343 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Mechanical compatibility of metallic composites. Corrosion in aqueous media. As a main condition for corrosion in aqueous media between components of a composite material, both components have to be touched by an invironmental wed atmosphere or of a fluid. If this condition is given contact corrosion can take place with any composite, independent of the mechanical compatibility of the components. Crevice corrosion is possible too if mechanical incompatibility (or extern loads) causes cracks between the components; stress corrosion cracking is possible as well. Stainless steel vires, for instance, can not reinforce the composit if attached by SCC. The other kinds of corrosion mostly dammage the matrix, which also reduces properties of the composit.Examples are given of possible kinds of corrosion for some fiber reinforced metallic composites and for metal laminates.
    Notes: Das Auftreten von Naßkorrosion zwischen den Komponenten eines Verbundwerkstoffs setzt voraus, daß beide Komponenten der umgebenden feuchten Atmosphäre oder einer umgebenden Flüssigkeit zugänglich sind. In diesem Fall kann bei jedem metallischen Verbund - faserig, lamellar oder geschichtet - und unabhängig von der mechanischen Verträglichkeit Kontaktkorrosion ausgelöst werden. Entstehen durch Unverträglichkeit (oder durch äußere Einflüsse) Risse, so kann Spaltkorrosion hinzukommen; und bei Eigenspannungen, wie auch bei äußeren Spannungen, kann Spannungsrißkorrosion beobachtet werden, sofern eine der Komponenten dagegen anfällig ist. Austenitische Stahldrähte z. B. neigen zu SpRK und können damit ihren Verstärkungseffekt einbüßen. Auch die anderen Korrosionsarten, die meist zu Lasten des Matrix- oder Grundwerkstoffs gehen, mindern in jedem Fall die Eigenschaften des Verbundes.Für einige Beispiele heute gebräuchlicher Verbundwerkstoffe werden die möglichen Korrosionsarten tabellarisch zusammengestellt.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070916
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  • 91
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    Thermische Ermüdung (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 353-356 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070921
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  • 92
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    Electronic Resource
    Nachrichten-Personalie (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. A107 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760070923
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  • 93
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    Bestimmung des Elastizitätsmoduls aus der Nachgiebigkeit angerissener Bruchmechanik-Proben (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 364-367 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Determining the moduls of elasticity from the compliance of precracked specimens. A new method is described which allows the determination of the modulus of elasticity of solid materials. Compliance tests with precracked fracture mechanics specimens in a simple tensile test machine yield accurate measurements of the modulus of elasticity in the orientation and material condition desired for fracture mechanics calculations.
    Notes: Es wird über ein neues Meßverfahren berichtet, den Elastizitätsmodul von Werkstoffen zu bestimmen. Es ist an einfachen Zerreißmaschinen durchzuführen und gibt Meßwerte des Elastizitätsmoduls in der für bruchmechanische Untersuchungen gewünschten Probenorientierung, Materialbeschaffenheit und Genauigkeit.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071005
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  • 94
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    Electronic Resource
    Der Einfluß der Porosität auf einige Eigenschaften von Wolfram/Kupfer-Kontaktwerkstoffen (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 376-380 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: The Influence of Porosity on a Few Properties of Tungsten/Copper Contact Materials. An investigation has been carried out on the influence of the amount of residual porosity on the electrical and mechanical properties of infiltrated tungsten/copper materials. By means of adding different quantities of infiltrating metal materials with a tungsten content of approximately 70 wt.% containing between 0,2 and 30% pores were produced. The following properties were measured for the different material specimens: are erosion rate, electrical conductivity, Vickers hardness number, and notch impact toughness. The arc erosion rate is not noticeably increased by pore contents up to 4%, all the other properties, however, are influenced considerably even by the smallest amount of measurable residual porosity. Thus it has to be concluded that infiltration with a slightly smaller quantity of infiltrating metal than that necessary to attain a pore-free material - a technique used occasionally in order to avoid the necessity of finishing the infiltrated parts - will lead to changes in quality.
    Notes: Es wird die für die praktische Fertigung von W/Cu-Tränkwerkstoffen wichtige Frage untersucht, inwieweit Restporositäten von Einfluß auf die elektrischen und mechanischen Eigenschaften sind. An Werkstoffen mit ca. 70 Gew.% Wolfram werden durch abgestufte Tränkmetallzugaben unterschiedliche Porositäten zwischen 0,2 und ca. 30% eingestellt und die Eigenschaften Abbrandverhalten im Hochstromlichtbogen, elektrische Leitfähigkeit, Vickershärte und Kerbschlagzähigkeit gemessen. Während Restporositäten bis zu 4% noch keine Erhöhung des Abbrandes bewirken, zeigen die übrigen Eigenschaften schon von kleinsten Porenanteilen an einen deutlichen Abfall. Die manchmal angewandte Fertigungsweise, durch geringe Unterschußtränkung eine mechanische Nachbearbeitung der Tränkteile zu vermeiden, ist mit den im Bericht aufgezeigten Qualitätsänderungen verbunden.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071007
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  • 95
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    Werkstoff  -  Konstruktion  -  Fertigung. Eine Berichtsreihe zur angewandten Werkstoffkunde für Studium und Praxis (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 390-391 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071009
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  • 96
    Electronic Resource
    Electronic Resource
    Kurze Informationen (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 392-392 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071010
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  • 97
    Electronic Resource
    Electronic Resource
    Masthead (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976) 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071101
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  • 98
    Electronic Resource
    Electronic Resource
    Das Schadensbild bei Kavitations-Korrosion von Reinaluminium Al 99,5 (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 409-413 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Cavitation-Corrosion - Types of Damage on the Surface of Pure Aluminium. By scanning electron microscope studies the development and propagation of plastic deformation and other types of damage are investigated.
    Notes: Mit Hilfe des Rasterelektronenmikroskopes werden die Ausbildung und der Fortschritt einer Werkstoffschädigung von Reinaluminium bei Kavitationsbeanspruchung studiert.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071105
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  • 99
    Electronic Resource
    Electronic Resource
    Problemlösungen durch Schichtverbundwerkstoffe in der ElektrotechnikVortrag anläßlich der Tagung „Verbandwerkstoffe“ der Deutschen Gesellschaft für Metallkunde vom 31. März bis 2. April 1976 in Konstanz (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. 413-417 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Clad Metals for Electrical Engineering. Materials with optimum properties for conducting springs can be produced by cladding a metallic sheat of high electrical conductivity between two sheats of a metal with high stiffness.Using suitable cladding components, thermo bi metals with different electrical resistance can be produced without essential variation of deflection and force. With this it is possible, to use groups of devices with uniform mechanical construction for different currents, which means a good technical as well as economic solution.High prices of noble metal based contact materials have led to the production of contact bimetals some years ago. Inspite of higher production costs these materials can be used very economically.
    Notes: Durch geeignete Anordnung hochfester und hochleitfähiger Komponenten in einem Schichtverbundwerkstoff lassen sich Werkstoffe mit optimalen Eigenschaften für stromführende Federn herstellen. Durch Verwendung geeigneter Plattierungskomponenten können Thermobimetalle mit unterschiedlichem elektrischen Widerstand ohne wesentliche Veränderung der Ausbiegung und der Kraftwirkung hergestellt werden. Somit ist es möglich, Gerätegruppen mit gleichem mechanischen Grundaufbau für verschiedene Stromstärken zu verwenden und damit technisch und wirtschaftlich günstige Problemlösungen zu erzielen.Der hohe Preis der Kontaktwerkstoffe auf Edelmetallbasis führte schon vor vielen Jahren zur Herstellung von Kontaktbimetallen. Trotz höherer Formkosten sind diese Werkstoffe in den meisten Fällen besonders wirtschaftlich einsetzbar.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071106
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  • 100
    Electronic Resource
    Electronic Resource
    Nachrichten-Hinweise (1976)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 7 (1976), S. A126 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19760071202
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