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  • 1995-1999
  • 1980-1984  (1.025)
  • 1975-1979  (1.143)
  • 1981  (1.025)
  • 1977  (1.143)
  • Inorganic Chemistry  (1.520)
  • Molecular Cell Biology  (224)
  • Physical Chemistry  (213)
  • Electron microscopy  (211)
  • Nuclear reactions
Materialart
Erscheinungszeitraum
  • 1995-1999
  • 1980-1984  (1.025)
  • 1975-1979  (1.143)
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Rheumatology international 1 (1981), S. 21-28 
    ISSN: 1437-160X
    Schlagwort(e): Rheumatoid nodules ; Polymorphonuclear granulocytes ; Electron microscopy ; Collagen degradation products
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular material and fibrillar remnants represent degraded collagen. Often these degradation products were present in the neighborhood of disintegrating PMNs. From this morphological relationship it is concluded that enzymes of PMNs may in part be responsible for the fibrinoid necrosis in rheumatoid nodules.
    Materialart: Digitale Medien
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  • 2
    ISSN: 1432-0711
    Schlagwort(e): Ovary ; FSH ; Inhibin ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of a highly purified preparation of human follicular fluid inhibin (hFF-Inhibin) on the ovary of immature rats have been studied. The highly purified preparation was obtained by gel and ion-exchange chromatography and ultrafiltration of the acetone dried extract of human follicular fluid. Administration of 5, 10, or 20 μg of inhibin daily for 10 days starting from day 11 postnatum resulted in (1) a significant reduction of basal FSH levels by the 20 μg dose but not by lower doses, (2) atresia of preantral and antral follicles in an apparently dose-related manner, (3) hyperplasia of the theca interna, and (4) degeneration of the granulosa cells, maximum damage being in the group treated with 20 μg. In inhibin-induced atretic follicles there were no signs of (a) granulosa cell-luteinisation, (b) connective tissue invasion, (c) hyalinisation of the basement membrane, or (d) vascularisation. Simultaneous administration of human menopausal gonadotrophin (hMG) led to luteinisation of the atretic follicles. However, the other structural alterations mentioned above (b-d), and those of the theca cells could not be overcome by hMG. In addition, there was no significant difference in the ovarian weight of animals treated with hMG when compared to those treated with inhibin and hMG, but the serum levels of the oestradiol in the latter were significantly lower. Our results suggest that hFF-inhibin acts not only at the pituitary, but also at the ovarian level.
    Materialart: Digitale Medien
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  • 3
    ISSN: 1432-2307
    Schlagwort(e): Liver biopsy ; Renal transplant recipients ; HBs and HBc Ag ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A prospective series of 45 liver biopsies taken from 22 renal transplant patients was investigated for the presence of hepatitis B antigen core (HBc) and surface (HBs) components by electron microscopy. At the time of each biopsy serum HBs Ag was sought by radioimmunoassay. Sections were taken for the detection of HBs Ag by immunofluorescence. In seropositive patients, intravesicular tubular structures resembling HBs Ag were found in 61% of biopsies while the intranuclear core HBc was present in 69%. No correlation could be made between the ultrastructural pattern of the viral components and the intensity of the histological liver damage. During the follow up, there was an accumulation of both HBs and HBc Ag even in a period as short as 1 year. The 9 liver specimens examined after three years of transplantation showed a marked accumulation of both antigens. Thus the expression of HB Ag at the hepatocellular level seems to correlate better with the duration of antigenaemia than with the histological pattern. Lastly, on matched semithin and ultrathin sections, the ground glass appearance of cytoplasm appeared to correlate with smooth endoplasmic reticulum distorsion, irrespective of the simultaneous presence or absence of intravesicular tubular structures. The sanded nuclei expressed a rare massive accumulation of core antigen.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 391 (1981), S. 165-175 
    ISSN: 1432-2307
    Schlagwort(e): Dermatofibrosarcoma protuberans ; Tissue culture ; Electron microscopy ; Fibroblasts ; Fibrosarcoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Dermatofibrosarcoma protuberans has been considered to be of fibrohistiocytic or fibroblastic origin. The purpose of this paper is to identify the original cell strain from which this neoplasm derives, using tissue culture and electron microscopic methods. Thirteen cases of DFSP characterised by clinical, topographical, histological and behavioral criteria were explanted. The emigrating cells were bipolar with two opposed processed and showed a radial arrangement in respect to the expiants. After the second week the distal processes tended to curve back towards the cell body forming flame-like structures. This cell morphology and cellular orientation persisted during the whole life of the culture. Electron microscopy was performed in three cases; the newly grown cells maintained an electron microscopic picture similar to that found in the original tumors. This pattern of behaviour is characteristic of fibroblastic tumors and has been found in explants of normal fibroblasts, of fibromatosis and of fibrosarcomas used as controls. On this basis, we believe that DFSP is a fibrosarcoma of the skin of low grade malignancy.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 390 (1981), S. 11-21 
    ISSN: 1432-2307
    Schlagwort(e): Electron microscopy ; Bladder neoplasms ; Measurement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ultrastructure of urothelium from 4 patients with no evidence of tumour was compared with that taken from 22 patients with bladder neoplasms of different grade and stage. Two features were quantified: the percentage of reduplication of the basal lamina and the percentage of discontinuous basal lamina. Tumours showed a lower percentage of reduplicated basal laminae than normal tissues, the difference being significant in 3 out of 4 types of tumours. The difference in frequency between normal tissues and non-recurring tumours was not significant, but there was a significant difference between normals and recurring tumours. All types of tumours showed discontinuities in the basal lamina, including 80% of those staged non-invasive by light microscopy. None of the normal tissues showed these. The percentage of discontinuities seen in non-recurrent tumours was half that seen in recurrent ones, but both groups were significantly higher than normals. Loss of continuity of the basement membrane distinguishes invasive from non-invasive tumours. However, there is a high probability of these being missed by light microscopy alone. Therefore, electron microscopic studies on recurrent bladder tumours would increase the accuracy of staging and prognosis.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1432-2307
    Schlagwort(e): Microfold (membraneous) cells ; Tuft cells ; Electron microscopy ; Horseradish peroxidase ; Sequential uptake
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 79 NMRI mice and Wistar rats were used for ultrastructural investigations of the sequential uptake of horseradish peroxidase (HRP) by M cells. In addition the ultrastructure of the so-called tuft-cells was reported. HRP, a foreign protein antigen, was applied either by injection (Owen 1977), or by stomach tube. After variable exposure times (5 min to 3 h) segments of the distal small intestine, containing Peyer's patches, mesenteric lymph nodes and liver tissue were removed. After fixation, they were reacted with H2O2-3,3′-diaminobenzidine tetrachloride and were examined by light and electron microscopy for HRP reaction products. The uptake of HRP mainly occurs through the M cells in the dome epithelium of Peyer's patches with a continual transport of the antigenic material into lymphoid cells, macrophages, and dendritic reticulum cells. In the 3 h specimens a few single HRP-positive lymphoid cells can be observed within the efferent lymphatics of Peyer's patches. In addition, a continual uptake of HRP by necrobiotic enterocytes was observed. It has also been shown that after 3 h HRP is located inside the Kupffer cells of the liver. These findings also support the presumption that antigenic material can be transmitted via the portal circulation. However, definite, quantitatively and permanently recorded uptake of HRP by brush border cells was not be observed. To exclude a toxic effect of the applied HRP on the enterocytic epithelium additional resorptive-physiological investigations were performed using the in vivo-perfusion-recirculation method and in vitro-accumulation of L-phenylalanine.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 391 (1981), S. 107-115 
    ISSN: 1432-2307
    Schlagwort(e): Hemangioendothelioma ; Esophagus ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The histology and electron-microscopy of a malignant hemangioendothelioma of the esophagus wall appearing in a 42 year old male is presented. By light microscopy the tumor is composed of vessels and capillary-like structures of an anastomosing nature covered by atypical endothelial cells. These cells infiltrate the intersticial spaces growing into the posterior mediastinal area. Electron microscopy confirms the endothelial nature of the neoplastic cells, showing characteristics of the cell type, as is the presence of Weibel-Palade bodies, filaments and active pinocytosis. Hemangioendothelioma should be differentiated from other vascular tumors (angiosarcoma) as are hemangiopericytoma or hemangioblastoma, being composed exclusively of malignantly transformed endothelial cells.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 391 (1981), S. 189-205 
    ISSN: 1432-2307
    Schlagwort(e): Crohn's disease ; Electron microscopy ; Ultracytochemistry ; Immunohistology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Immunohisto- and ultracytochemical studies were carried out on surgical and biopsy specimens from 27 patients suffering from Crohn's disease of the ileum or colon. Control specimens were obtained from 16 patients with nonspecific proctitis or neoplastic disorders of the caecum or rectum. Our results suggest that the initial lesions in Crohn's disease are associated with a typical humoral immune response. In non-ulcerated mucosa a uniform increase of IgA-, IgG- and IgM-cells was found (numbers of IgA-cells: IgG-cells ∼14.4), whereas disproportional increases of IgG- and IgE-cells were observed in ulcerated mucosa (IgA:IgG ∼0.7). The IgE-cell multiplication in ulcerated areas suggests the possibility of local hypersensitivity reactions. Macrophages and granulocytes contained IgG, which was also demonstrated in multinucleated giant cells. The granulomas contained extracellular IgG, acid phosphatase and peroxidase. The finding of potentially harmful extracellular lysosomal enzymes may be of pathogenetic significance in view of the hypothesis of Weissmann (1964). Micro-ulcerations of the dome epithelium of hyperplastic Peyer's patches were seen by electron microscopy a finding which can be interpreted as an early lesion through which luminal antigens gain uncontrolled access to Peyer's patches. This could lead to (1.) overstimulation of the local immune system, (2.) disturbance of local immune homeostasis, (3.) imbalanced Ig-production with disproportional increases in IgG and IgE. We were not able to detect Clq or C3 bound to epithelial or vascular basement membranes, and no electron dense deposits were found. Viral particles or bacteria in any of the specimens were not demonstrated by electron microscopy. The type of immune response in Crohn's disease and its pathogenetic significance with remain unclear until more is known about the specificity of the locally produced antibodies.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 392 (1981), S. 135-145 
    ISSN: 1432-2307
    Schlagwort(e): Malignant fibrous histiocytoma ; Sarcoma ; Soft tissue neoplasms ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ultrastructural findings in 17 cases of malignant fibrous histiocytoma (MFH) are described. The tumors consisted of fibroblast-like cells and histiocyte-like cells in different proportions in different cases. Intermediate, undifferentiated, xanthomatous and multinucleated giant cells were also identified. In 12 of 17 cases myofibroblasts were evident. Acid phosphatase activity was detected cytochemically in the Golgi zone, endoplasmic reticulum and lysosomes (GERL) mainly within histiocyte-like cells, in three cases. These observations indicate that the GERL of the tumor cells are engaged in the formation of lysosomes. The polymorphic cellular composition, including undifferentiated cells, lends support to the concept that the MFH originates from a primitive multipotent undifferentiated mesenchymal cell.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 392 (1981), S. 231-239 
    ISSN: 1432-2307
    Schlagwort(e): Bronchial gland adenoma ; Oncocytoma ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Benign adenomas derived from the bronchial mucous glands are uncommon. Probably the least common variety is the oncocytomatous adenoma, this case being the second known example. The tumour was situated in the right main bronchus in a man aged 75. An oncocytomatous adenoma should be clearly distinguished from the common oncocytomatous change which affects the normal bronchial mucous gland cells seen in adults. The eosinophilic, columnar tumour cells seen by light microscopy contained numerous and prominent mitochondria by electron microscopy and granules of serous secretion. Other tumour cells contained microfilaments and were perhaps of myoepithelial origin. The true oncocytomatous mucous gland adenoma needs to be distinguished from an oncocytomatous bronchial carcinoid tumour the cells of which contain dense core granules of neurosecretory type. The bronchial oncocytomatous adenoma appears to be a benign tumour with a close similarity to its counterpart occuring in the salivary glands.
    Materialart: Digitale Medien
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Virchows Archiv 394 (1981), S. 31-47 
    ISSN: 1432-2307
    Schlagwort(e): Blood vessel neoplasms ; Electron microscopy ; Histochemistry ; Angiosarcoma ; Breast neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A total of five haemangiosarcomata and two benign haemangiomas arising in the mammary gland have been studied electron microscopically and by histochemical techniques. Malignant tumors were mainly composed of endothelial cells reactive to alkaline phosphatase and adenosine triphosphatase, and of pericytes and undifferentiated mesenchymal elements. A juvenile haemangioma showed a more structured wall with an increase of endoplasmic reticulum and filaments, and a diminution of membrane modulations and rod-like tubular bodies. A cavernous haemangioma showed an ultrastructure very similar to normal vessels. The ultrastructural and histochemical data suggest a blood vessel origin of mammary angiosarcomas and show that vascular neoplasms of the breast, benign or malignant, are composed of a combined proliferation of the different cell types present in the vessel wall, as described in other organs.
    Materialart: Digitale Medien
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  • 12
    ISSN: 1432-2307
    Schlagwort(e): Labial salivary gland biopsy ; Gougerot-Sjögren's syndrome ; Clinico-pathology ; Histoenzymology ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 119 cases of Sjögren's syndrome are described. Clinically, the female sex predominates (83% of cases); the average age is 56 years. Isolated sicca syndrome is noted in 31 % of cases; it is more often associated with rheumatoid polyarthritis (64%) or with another collagen disease (5%). In addition, in 5 patients, we have found a malignant lymphoproliferative disease in an accessory or a main salivary gland (4 non-Hodgkin malignant lymphomas, 1 chronic lymphoid leukaemia). In all cases, a biopsy from accessory labial glands or from a main salivary gland, corroborates the diagnosis. Histologically, epi-myoepithelial islets are always lacking in accessory glands. We classified labial gland injuries in three groups based on striated duct distention: first, some tubular ectasia with interstitial lymphoid cells; second, much ectasia associated with many lymphoid cells and the beginning of pericanalar sclerosis; third, intensive ectasia, scarce lymphocytes, severe peri- and intralobular sclerosis and extensive destruction of acini. This grading is positively correlated with that of parotid biopsies and also with abnormalies on numerous parotid sialographic radiograms performed simultaneously. The histoenzymological study demonstrates decreased activity of oxydative enzymes in striated duct epithelia and of ATPases in myoepithelial cells. The ultrastructural study confirms these findings. Even at an early stage of the disease, tubular alterations are observed: epithelial cell degeneration (vacuolated mitochondria, loss of cytoplasmic lateral membrane foldings) and myoepithelial cell damage (in particular disappearance of myofilaments). These findings explain tubular ectasia by the loss of contractile function. Simultaneously, intensive regeneration from the intercalated ducts by young “totipotent” cells, sometimes differentiating into epidermoid, secretory or myoepithelial cells, are observed. Lesions in acinar cells are less marked: conglomeration of secretory granules, some autophagosomes and rarely true necrosis. In the interstitial tissue, amongst lymphocytes, plasmocytes and mastocytes, numerous myoepithelial cells are present: young pseudo-fibroblastic cells with poor ergastoplasm and some myoid organelles (a few myofilaments, dark zones and endocytosis vacuoles on cell membrane; degenerated myoepithelial cells whose scanty dark cytoplasm is filled with lipid droplets). Thus, by analogy with the myoepithelial islets observed in parotid biopsies, the myoepithelial cell damage seems to have a specific signification in Sjögren's disease. Regeneration from the intercalated ducts fails to repair these cells and to restore their physiological contractile function. Furthermore, this leads to extratubular migration of young myoid cells which are responsible for progressive accumulation in the interstitial tissue of membranoid material and later collagen sclerosis.
    Materialart: Digitale Medien
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  • 13
    ISSN: 1434-0879
    Schlagwort(e): Dog prostate ; Stereological analysis ; Electron microscopy ; Oestrogen effect
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The stromal tissue of the prostate in normal castrated dogs and castrated and oestrogen treated dogs were studied by quantitative morphological methods. Quantitative morphological (=stereological) procedures provide values of volume, surface and number of tissue and cell components. The stereological data show an activation of the smooth muscle cell of the stromal tissue in the oestrogen treated dog compared with the control group; related to the unit volume of smooth muscle cell cytoplasm, a threefold increase of the endoplasmic reticulum was observed in castrated and oestrogen treated dogs.
    Materialart: Digitale Medien
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Research in experimental medicine 178 (1981), S. 165-175 
    ISSN: 1433-8580
    Schlagwort(e): Perfused rat pancreas ; Insulin secretion ; Uric acid ; Light microscopy ; Electron microscopy ; Rattenpankreasperfusion ; Insulinsekretion ; Harnsäure ; Lichtmikroskopie ; Elektronenmikroskopie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es ist bekannt, daß die Methylxanthine Coffein und Theophyllin die Insulinsekretion positiv beeinflussen. Im Rahmen von Perfusionsversuchen sollte untersucht werden, ob die Inselzellfunktion auch dem Einfluß der chemisch eng verwandten Harnsäure unterliegt. Zugleich sollte eine Destruktion von Inselzellstrukturen durch Harnsäure ausgeschlossen werden, da die chemisch ähnlich configurierte Substanz Alloxan bekanntlich Inselzellnekrosen verursacht. Dazu wurden isolierte Rattenbauchspeicheldrüsen mit Glukosekonzentrationen von 100 mg/100 ml und 300 mg/100 ml stimuliert. In einem Teil der Fälle wurde dem Perfusat Harnsäure in der Konzentration von 12 mg/100 ml zugegeben. Es zeigte sich, daß Harnsäure die Insulinsekretion bei Stimulation mit Glukose in der Konzentration von 100 mg/100 ml nicht beeinflußt. Werden die B-Zellen jedoch mit einer Glukosekonzentration von 300 mg/100 ml stimuliert, so steigert Harnsäure die Hormonfreisetzung im Sinne eines glukosepotenzierenden Effektes um mehr als 100%. Anhand charakteristischer Sekretionsphänomene sowie lichtoptischer und elektronenmikroskopischer Untersuchungen konnte nachgewiesen werden, daß es sich hierbei um eine echte Mehrsekretion handelt und nicht etwa um einen Auslaufeffekt als Folge einer Destruktion von Inselzellstrukturen durch eine alloxanähnliche Wirkung der Harnsäure.
    Notizen: Summary Methylxanthines, such as caffeine and theophylline, show effects increasing the secretion of insulin. Perfusion experiments were intended to find out whether insulin secretion is even influenced by uric acid, which is chemically closely related. Besides, it was to be demonstrated that uric acid causes no damages to islet cell structures for it is well established that alloxan, which is chemically related to uric acid, produces necroses in B cells. Isolated rat pancreata were stimulated by glucose at concentrations of 100 mg/100 ml and 300 mg/100 ml. In part of the experiments uric acid was added to the perfusion medium at a concentration of 12 mg/100 ml. We found that uric acid has no influence on insulin secretion if it is stimulated by glucose at a concentration of 100 mg/100 ml. However, if B cells are stimulated by glucose at a concentration of 300 mg/100 ml insulin secretion is enhanced by the addition of uric acid by more than 100%. This indicates that this substance exhibits a glucose-potentiating effect. The characteristic dynamics of insulin secretion demonstrate together with light- and electron-microscopic investigations that uric acid causes a real additional secretion and no leaking of intracellular insulin as a result of destruction of islet cell structures by an effect of uric acid similar to that of alloxan.
    Materialart: Digitale Medien
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 54 (1981), S. 203-210 
    ISSN: 1432-0533
    Schlagwort(e): Retina ; Schwann cell ; Myelinated nerve fibers ; Nodes of Ranvier ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Myelination of axons in the nerve fiber layer (NFL) of the retina occurs as a sporadic abnormality in several mammalian species including man, monkey, cat and rat. All of these species have vascularized retinae and, in the latter three, ultrastructural studies have demonstrated the pattern of medullation to be similar to Schwann cell myelination in the peripheral nervous system. This contrasts with an oligodendrocytic pattern of myelination normally present in the avascular retina of the rabbit. One possible explanation for this difference is that the pattern of myelination is related to the presence or absence of retinal blood vessels. The present investigation provides the first evidence of NFL myelination in another avascular retina, that of the guinea pig. Myelination in the guinea pig retina was observed in a single bundle of axons and involved only large diameter fibers. With several axons, myelin sheaths terminated at hemi-nodes of Ranvier and in all such cases this occurred in association with marked paranodal infolding. Morphological characteristics of the myelination include (1) a one to one relationship between axon and myelinating cell, (2) cytoplasm between myelin sheath and plasma membrane, (3) basal lamina surrounding the myelinating cell, (4) collagen fibers in the adjacent extracellular space and (5) double intraperiod lines. These morphological features are characteristic of peripheral nerve myelination by Schwann cells. Thus, in all species so far described in which retinal medullation is abnormally present, the pattern of myelination has been Schwann cell in nature rather than oligodendrocytic. The reasons for this Schwann cell predominance remain undefined.
    Materialart: Digitale Medien
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 54 (1981), S. 233-237 
    ISSN: 1432-0533
    Schlagwort(e): Methylmercury ; Mice ; Golgi methods ; Electron microscopy ; Dendrites ; Purkinje cells ; Perivascular glia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Neonatal C57BL/6J mice were injected with 5 mg/kg body weight of203Hg-labeled methylmercuric chloride on postnatal days 3, 4, and 5, totaling 15 mg/kg body weight per animal. The experimental and control animals were sacrificed on postnatal day 15. Whole body radioactivity of203Hg progressively increased during the 3-day injection period and reached the peak level and remained at peak levels until the time of sacrifice. This indicates a lack of clearance of203Hg by neonatal mice during the period examined in this study. Golgi preparations of cerebella of MeHg-treated animals revealed significant reduction in dendritic arborization of Purkinje cells. Ultrastructurally, the vascular endothelium showed attenuation with increased electron density and frequent vacuolization of cytoplasm. Marked swelling of perivascular glia was noted in most of the capillaries throughout the cerebella of MeHg-treated animals.
    Materialart: Digitale Medien
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 55 (1981), S. 77-80 
    ISSN: 1432-0533
    Schlagwort(e): Esthesioneuroepithelioma ; Olfactory neuroblastoma ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A rare case of esthesioneuroepithelioma infiltrating the right frontal lobe is reported in a 41-year-old man. This tumor composed of compact lobules with tubular arrangements, ultrastructurally showed two different cell types, both devoid of neurosecretory granules and reminiscent of neurons and sustentacular cells of the olfactory epithelium. These features are distinguished from those generally observed in olfactory neuroblastomas.
    Materialart: Digitale Medien
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 55 (1981), S. 89-95 
    ISSN: 1432-0533
    Schlagwort(e): Electron microscopy ; Morphometry ; Sorbitol pathway ; Diabetes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Galactose neuropathy is characterized by progressive endoneurial edema manifested by a gradual increase in endoneurial fluid pressure. Edema accumulates via a unique mechanism of osmotic force generated by products of the polyol pathway, synthesized within the endoneurial compartment. This paper presents morphologic findings showing firstly, that blood nerve barrier permeability to horseradish peroxidase complexes appears unchanged and secondly, peripheral nerve edema in this condition is restricted to extraganglionic endoneurium sparing the spinal ganglia and adjacent roots. Thirdly, mast cells accumulated in significant numbers and electron microscopy revealed degranulation. There was no evidence of edema in Schwann cell cytoplasm, the putative site of galactitol accumulation via the sorbitol pathway. These findings are discussed with respect to diabetic neuropathy for which galactose intoxication is a useful experimental model.
    Materialart: Digitale Medien
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  • 19
    ISSN: 1432-0533
    Schlagwort(e): Postischemic recirculation ; Complete cerebral ischemia ; Ischemic neuronal injury ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The neuronal response to complete cerebral ischemia (CCI) of 5–15 min duration was evaluated at the light and electron microscopic level subsequent to postischemic recirculation periods of up to 60 min. Following postischemic reperfusion, the homogeneous neuronal changes characteristic of permanent CCI were modified into a heterogeneous pattern of selectively vulnerable neuronal responses. Four basic types of neuronal injury were represented within this heterogeneous neuronal population. The Type I neuronal response was most numerous and consisted of chromatin clumping, nucleolar condensation and a breakdown of polysomes. This response may represent a reversal of some of the neuronal changes observed after permanent CCI. In addition to the above changes, Type II neurons contained swollen mitochondria and Golgi saccules which appeared as microvacuoles under the light microscope. Type III neurons displayed varying degrees of neuronal shrinkage and numerous swollen mitochondria. Type IV neurons were markedly shrunken and electron-dense with few identifiable subcellular structures. The distribution of Type I neurons was random but the other neuronal responses occurred in “selectively vulnerable” brain regions. The number of Type II, III, and IV neurons increased with extended insult durations but were unaffected by the length of recirculation. Ten minutes of CCI represented the threshold for a significant increase in the number of severely altered neurons. These findings suggest that considerable neuronal injury may be present after 10–15 min of CCI, and the lack of a recirculation period following CCI appears to afford the brain parenchyma an extensive degree of structural protection.
    Materialart: Digitale Medien
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  • 20
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 53 (1981), S. 65-74 
    ISSN: 1432-0533
    Schlagwort(e): Hexachlorophene ; Central nervous system ; Mice ; Baboons ; Electron microscopy ; Neurotoxicology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A study on hexachlorophene encephalopathy in mice and baboons is reported. By light microscopy, a severe spongiform lesion of the central nervous system (CNS) was localized in the white matter, without myelin breakdown or cellular reaction. By electron microscopy, the myelin alteration was characterized by wide intralamellar spaces or “splitting” developed in the intraperiod line of compact sheaths. The acute changes described were induced by administration of the drug by the digestive or cutancous routes at various dosage levels in an aqueous solution or in talcum powder. The toxic effects depended on the age of the animals, the survival times and the concentrations of hexachlorophene, i.e., 6%, 3%, and 0.5%. The findings are compared with previous reports on the neurotoxicity of hexachlorophene and other chemicals in humans and experimental animals. Hexachlorophene cannot be recommended for use in young infants because of its neurotoxicity in very low doses as demonstrated in the present report.
    Materialart: Digitale Medien
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  • 21
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 53 (1981), S. 165-168 
    ISSN: 1432-0533
    Schlagwort(e): Lewy body ; Neurofibrillary tangle ; Locus ceruleus ; Aged brain ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The presence of Lewy body and neurofibrillary tangle in the locus ceruleus neurons of aged brain is described. Ultrastructural study revealed that in some Lewy bodies the presence of “twisted tubules” or “paired helical filaments” amongst the filaments of the Lewy body. A quantitative analysis of serial sections of locus ceruleus from aged brain, incidences of the Lewy body and neurofibrillary change were 0.07% (9/11,515) and 6.6% (15/11,515), respectively. The incidence of neurons containing both structures was 0.008% (1/11,515).
    Materialart: Digitale Medien
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  • 22
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 54 (1981), S. 43-53 
    ISSN: 1432-0533
    Schlagwort(e): Uremia ; Kidney transplantation ; Polyneuropathy ; Light microscopy ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Eighteen patients, ten with clinical uremia and eight with functioning kidney transplants, were studied clinically for neuropathy and were subsequently subjected to a sural nerve biopsy. The biopsy specimens were studied using light and electron microscopic and morphometric methods. The clinical polyneuropathy was qualitatively and quantitatively most severe in the hemodialysis group. These results conformed with the light and electron microscopic observations. Clinical, morphological and morphometric indications of recovery from uremic neuropathy were observed in the transplant recipients. The pathophysiology of uremic peripheral neuropathy was marked axonal degeneration. Pathologic Schwann cells were also frequently found. Axonal degeneration and Schwann cell damage seemed to exist independently of each other. In morphometric analysis, axonal atrophy and abnormal myelin sheath thickness were observed in all patient groups. A close relationship was found between axonal atrophy and low conduction velocity. Unexpectedly low nerve conduction velocities were also observed, which cannot be explained by either loss of nerve fibers or demyelination. The findings of damaged endoneural blood capillaries supported the ischemic theory as one mechanism in the pathogenesis of uremic neuropathy.
    Materialart: Digitale Medien
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  • 23
    Digitale Medien
    Digitale Medien
    Springer
    Anatomy and embryology 161 (1981), S. 433-451 
    ISSN: 1432-0568
    Schlagwort(e): Rhombencephalon, rat ; Subependymal cysts ; Morphogenesis ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A bilaterally symmetrical cystic cavity is situated in the subependymal neuropil of the rostral rhombencephalon of the rat during the perinatal period of ontogeny. These cysts are formed by the confluence of enlarged extracellular spaces in this region between E18 and E20. The cysts are present for about 2 weeks but disappear on about P15 without trace. They have a maximal volume of about 0.004 to 0.006 mm3 on P2, with a rostrocaudal extension of about 200 μm. Their shape is characterized by a medial convexity and a lateral concavity, and they have their maximal circumference at about the middle of the rostrocaudal axis. The caudal portion is juxtaposed to the subependyma, while the rostral part lies in the neuropil of the presumptive griseum centrale pontis. In the lumen and the wall of the cysts are found numerous macrophages, hlioblasts and some degenerating axons and dendrites. The significance of these cysts in the context of morphogenesis and the origin of the numerous macrophages within them are both unresolved.
    Materialart: Digitale Medien
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  • 24
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 53 (1981), S. 237-248 
    ISSN: 1432-0533
    Schlagwort(e): Thyroxine effect on muscle ; Histochemistry ; Immunopathology ; Electron microscopy ; Diagnostic muscle pathology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Proximal myopathy and different types of neuromuscular syndromes are frequently observed in hyperthyroid patients with complicated thyrotoxicosis. Conflicting reports on the changes seen in muscle biopsies range from no abnormalities to muscle necrosis with the fibers being replaced by connective tissue and fat. On the basis of 21 skeletal muscle biopsies from chronic thyrotoxic myopathic patients, coupled with studies in experimentally induced triiodothyronine myopathy in rats, the histological, histochemical, immunofluorescent, and electron-microscopic findings diagnostic for thyrotoxic myopathy are defined. These criteria include: clumping of nuclei, los of cross-striation, vacuolar degeneration, and fatty infiltration of endo- and perimysium, presence of giant mitochondria, increased number of mitochondria, disorganization of contractile elements, swelling of transverse tubules, presence of microtubular aggregations, and a significant increase of lipofuscin granules. Both muscle fiber types or in some cases selective type II fibers display atrophy with signs of reinnervation. These alterations are polyfocal and polyphasic and, therefore, polychronous and stereotyped rather than pathognomonic. However, they are related to the severity of thyrotoxic myopathy and the duration of disease. The results of muscle biopsies have a predictive value in determining the reversibility or irreversibility of pathologic changes with therapeutic consequences.
    Materialart: Digitale Medien
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  • 25
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 55 (1981), S. 143-149 
    ISSN: 1432-0533
    Schlagwort(e): Pineal parenchymal neoplasm ; Electron microscopy ; Primitive neuroectodermal cell ; Dense core vesicles
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The fine structure of two pineal parenchymal neoplasms has been described. The tumors contained a predominance of small, poorly differentiated cells with prominent nuclei and scanty cytoplasm. These cells were similar to those found in medulloblastomas, primitive cerebral neuroectodermal tumors, and fetal cerebellum and cerebrum. Some cells contained 9+0 cilia, dense core vesicles, and processes containing microtubules and numerous dense core and clear vesicles, suggesting neuronal differentiation. Astrocytic elements were also present. This study suggests that the predominant cells of these tumors are primitive neuroectodermal elements which have the potential to differentiate along several different lines.
    Materialart: Digitale Medien
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  • 26
    ISSN: 1432-0533
    Schlagwort(e): Immunochemistry ; Pituitary adenoma ; Electron microscopy ; Mixed eosinophilic-cromophobe ; Gonadotropin ; Thyrotropin-secretion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Twenty-nine pituitary adenomas were studied by histologic, electron-microscopic, and immunohistochemical techniques. By conventional histological stains, 19 cases were considered chromophobe, five cosinophilic, and five mixed chromophobe and eosinophilic adenomas. Immunohistochemistry, with specific antibodies against human GH, PRL, FSHβ, LHβ, and TSHβ showed, clearly, secreting and non-secreting groups of tumors: growth hormone-secreting adenomas (four cases), prolactin-secreting adenomas (eight cases), thyrotropin and/or gonadotropin-producing tumors (seven cases), and non-secreting adenomas (ten cases). Electron microscopy showed secretory granules of varying numbers, sizes, and shapes in all tumor cells in all 29 cases. The endoplasmic reticulum appeared markedly increased in 5/8 of the prolactin producing tumors; mitochondria also appeared markedly increased in 3/7 of the thyrotropin-gonadotropin group. These three cases could be considered “oncocytomas” by electron-microscopic criteria. Patients with prolactin-secreting adenomas had high serum prolactin and typical clinical symptoms associated with such tumors. One patient with large numbers of TSH-containing cells in her tumor and some cells with growth hormone and FSH had overt thyrotoxicosis. Although the remaining six tumors stained specifically for one hormone or another, no clinical correlation was possible. Conventional electron microscopy has some value in the generic identification of puritary tumor cells, but no value in the recognition of specific secretory products or specific cell types. Conventional histopathology is the least reliable method to correctly identify a specific type of pituitary adenoma, beyond the identification of the adenomatous changes. This study demonstrates the existence of gonadotropin- and/or thyrotropin-secreting pituitary adenomas, among so-called chromophobe adenomas, or “undifferentiated adenomas”.
    Materialart: Digitale Medien
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  • 27
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 55 (1981), S. 307-318 
    ISSN: 1432-0533
    Schlagwort(e): Diphtheritic polyneuropathy ; Muscle biopsy ; Intramuscular nerves ; Electron microscopy ; Histochemistry ; Diphtherie-Polyneuropathie ; Muskelbiopsie ; intramuskuläre Nerven ; Elektronenmikroskopie ; Histochemie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Biopsien aus Extremitätenmuskeln von vier Kranken mit schwerer tetraplegischer Form der Diphtherie-Polyneuropathie konnten nahe dem Höhepunkt der Erkrankung gewonnen und mit modernen Methoden einschließlich Histochemie, Elektronenmikroskopie und morphometrischer Verfahren untersucht werden. Vergleichbare Studien wurden bisher nicht veröffentlicht. Die Muskulatur bot vorwiegend neurogene Veränderungen mit disseminierten angulierten Fasern, eine besonders die Typ-2B-Fasern betreffende, mehr generaliierte Atrophie sowie Targetoidherde oder „Cores” in Typ-1-Fasern. Darüber hinaus fanden sich eindeutige myogene Veränderungen mit unterschiedlichen Degenerationsphänomenen bis zur totalen Nekrose, offenbar — wie am Herzmuskel —toxischer Herkunft. Das neurogen-myogene Mischbild entsprach den elektromyographischen Befunden. Die intramuskulären Gefäße waren unauffällig bis auf vereinzelte perivaskuläre, vorwiegend mononukleäre Zellinfiltrate mit reichlich zerebriformen lymphoiden Zellen, wahrscheinlich T-Lymphozyten. An 11 intramuskulären Nerven und zwei motorischen Endplatten waren eindeutig auf die Diphtherie zu beziehende Veränderungen nicht aufzudecken. Dies kann als Hinweis auf eine vorwiegend proximale Entmarkung bei der Diphtherie-Polyneuropathie des Menschen gedeutet werden, die damit eher der experimentellen Form des Kaninchens als der des Meerschweinchens entspricht.
    Notizen: Summary Mucle biopsies from the lower extremities of four patients with severe tetraplegic form of diphtheritic polyneuropathy were examined by modern techniques including histochemistry, electron microscopy and morphometric procedures. Until now comparable studies have not been published. The biopsies were removed during the acute stage of the polyneuropathy. We found scattered small angulated muscle fibers beside a more generalized slight atrophy predominantly of type 2B fibers and targetoid-phenomenons or cores in type 1 fibers. Beside this neurogenic pattern there also were, corresponding with the results of electromyography, primary myogenic alterations with different degenerative phenomenons, suspicious of toxic origin as in cardiac muscle. The intramuscular vessels showed no abnormalities except some perivascular predominantly mononuclear cellular reactions with a remarkable number of cerebriform lymphoid cells, probably T-lymphocytes. No specific pathological alterations could be detected in 11 intramuscular nerves and two motor endplates. This may reflect the more proximal demyelination of human peripheral neurons by the diphtheria toxin as found in experimental diphtheria of the rabbit in contrast to the more distal type of the guinea pig.
    Materialart: Digitale Medien
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  • 28
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 54 (1981), S. 287-292 
    ISSN: 1432-0533
    Schlagwort(e): Mucopolysaccharidoses III ; Sanfilippo's syndrome ; Histochemistry ; Electron microscopy ; Lipofuscin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A histochemical and ultrastructural study was made on the brain of a 23-year-old man with Sanfilippo's syndrome. In accordance with previous reports the cortical nerve cells contained a PAS-positive lipid storage substance. This showed intense autofluorescence in UV-light and was positive with various stains for lipofuscin. The storage material appeared ultrastructurally as inclusion bodies composed of short lamellated membranes, granular material, and vacuoles. In addition, concentrically and transversely lamellated membranous cytoplasmic bodies were observed in the nerve cells. It is concluded that the PAS-positive lipid storage material in the neurons was composed partly of lipofuscin in addition to other lipids presumably glycosphingolipids.
    Materialart: Digitale Medien
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  • 29
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 55 (1981), S. 81-87 
    ISSN: 1432-0533
    Schlagwort(e): Canine CNS ; Myelination ; Hypomyelinogenesis ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ultrastructure of myelin deficiency in Chow Chow dogs was studied in the spinal cord of a 15-month-old and a 3-year-old animal. It was found that myelination progresses with age in these dogs but is still deficient at the age of 3 years. The findings included axons with thin or uncompacted myelin sheaths, separated from each other by massive astrocytosis, and bizarre myelin formations. Normal numbers of morphologically normal oligodendrocytes were present in the myelin-deficient areas. The disease in these Chow Chow dogs consists of a strongly retarded myelination which is possibly due to a dysfunction or delay in glial maturation.
    Materialart: Digitale Medien
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  • 30
    Digitale Medien
    Digitale Medien
    Springer
    Archives of dermatological research 271 (1981), S. 171-182 
    ISSN: 1432-069X
    Schlagwort(e): Hypomelanotic macule ; Tuberous sclerosis ; Electron microscopy ; Hypomelanotische Macula ; tuberöse Hinrsklerose ; Elektronenmikroskopie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Hypomelanotische Maculae der Haut bei der tuberösen Hirnsklerose (TS) werden verursacht durch einen komplizierten Prozeß, in den die Synthese und Reifung von Melanosomen verwickelt sind. Weil die Charakterisierung von Hautbiopsien aus hypomelanotischen Maculae bei TS-Patienten zur Zeit nicht ausreichend ist, haben wir eine quantitative Methode entwickelt, durch die die Reifung der Melanosomen in den Melanocyten erforscht wird. Diese Methode wurde anhand von Biopsien aus hypomelanotischer und der angrenzenden Haut von sechs Patienten mit erwiesener TS geprüft und mit bekannten Methoden verglichen. Bei allen sechs Patienten wurde in der hypomelanotischen Macula eine statistisch signifikant niedrigere Zahl von pigmentierten Melanosomen pro melanocytärem Perikaryon und dendritischem Zellprozeß festgestellt als in der angrenzenden Haut. Die relative Anzahl von Stadium III- und IV-Melanosomen hatte in der hypomelanotischen Macula abgenommen, die von Stadium II-Melanosomen zugenommen (auch statistisch signifikant). Durch Verwendung unserer Methode kann die Hypomelanose der TS zuverlässig charakterisiert werden, was möglicherweise aus diagnostischer Sicht wichtig ist. Die Resultate der Melanosomengrößenmessung oder die des DOPA-Verfahrens dagegen waren statistisch nicht signifikant.
    Notizen: Summary Hypomelanotic macules of the skin in tuberous sclerosis (TS) are caused by a complex process, involving the synthesis and maturation of melanosomes. A quantitative method was developed to investigate the maturation of the melanosomes at the level of the melanocytes. The method was tested on biopsies of hypomelanotic and adjacent normomelanotic skin from six patients with definite TS, and compared with other methods. In all patients, a statistically significant lower number of pigmented melanosomes was found per cross-sectioned melanocytic perikaryon and dendritic cell process in the hypomelanotic as compared to the normomelanotic skin. The relative numbers of stage III and IV melanosomes were decreased, and of stage II melanosomes increased in the hypomelanotic macule (also statistically significant). This indicates that it is possible to characterize the hypomelanosis in TS reliably, which may have diagnostic importance. In our hands, assessment of the size of the melanosomes did not show a statistically significant difference between hypo- and normomelanotic skin; the difference found with the DOPA technique was more evident, although not statistically significant.
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  • 31
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 33 (1981), S. 143-151 
    ISSN: 1432-0827
    Schlagwort(e): Calcium transport ; Cytochalasin B ; Dihydrocytochalasin B ; Colchicine ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary In vivo calcium absorption was studied in normal and rachitic chicks. Cytochalasin B (CB) at a concentration of 25 µg/ml added to the medium inside the duodenal lumen inhibited calcium absorption (20 min) from 82.5±1.9% of calcium absorbed in the controls to 59.2±3% in normal and from 70.0±2.3% to 47.0±2.1% in rachitic chicks. In vitro studies by everted ileal sacs of young rabbits also showed an inhibition of active transport of calcium due to CB. Whereas in the controls the ratio of45Ca concentrations in serosal and mucosal media (60 min) was 7.2±0.32, the ratios were 5.24±0.52; 4.40±0.36; 3.40±0.42; 5.77±0.52; 1.38±0.08; and 1.06±0.02 in the presence of CB at concentrations of 5, 10 and 25 µg/ml; colchicine 10−4M, Na citrate 0.02M, and heat-devitalized conditions, respectively.45Ca concentration in the mucosal scrapings was also affected. It showed an increase from controls (15,101±404 cpm/mg) and correlated with CB concentration: 17,378±489, 19,015±1000, and 20,201±362 at 5, 10, and 25 µg/ml, respectively. Dihydrocytochalasin B also inhibited active calcium transport and caused an increase in45Ca concentration in the mucosal scrapings. Correlated electron microscopic studies showed certain changes in the brush border, especially in some actin microfilaments in the terminal web region. It seems that these morphological alterations may be related to transcytoplasmic movement of calcium.
    Materialart: Digitale Medien
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  • 32
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 33 (1981), S. 381-384 
    ISSN: 1432-0827
    Schlagwort(e): Alcohol ; Electron microscopy ; Growth plate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary We have previously demonstrated that ethanol has a direct toxic effect on the rat skeleton characterized by decreased trabecular bone volume. In the present study, we examined the ultrastructure of the distal radial epiphyseal growth plates in these same animals. Eight weeks of ethanol administration to 12 male rats results in serum alcohol levels of 140 mg/dl but did not alter the width or light microscopic appearance of the radial growth plate. Quantitative electron microscopy failed to demonstrate morphologic evidence of toxicity in the skeletal cells. We conclude that although ethanol appears to have a direct effect on rat bone characterized by enhanced resorption, toxicity is not attended by ultrastructural changes in the skeletal cells.
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  • 33
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 33 (1981), S. 529-540 
    ISSN: 1432-0827
    Schlagwort(e): Bone cells ; Electron microscopy ; PTH ; PGE1
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Four different cell populations—designated PF, OB, OC, and PC—were isolated from calvaria of 18-day-old chick embryos for analysis of the effects of hormones on bone tissue. The cell populations were studied with histological and biochemical methods. Apart from the well-known cell types present in calvaria, a new cell type was found in the noncalcified organic matrix between the osteoblastic layer and the calcified matrix. These cells were provisionally called osteocytic osteoblasts. They represent the “transition state” between osteoblasts and osteocytes. On the basis of histological studies with light microscopy (LM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM), the PF population was considered to originate primarily from the periosteal fibroblasts, the OB population from the osteoblasts and osteocytic osteoblasts. The population of cells still present in calvaria after removal of periosteal fibroblasts and osteoblasts was called the OC population. This cell population was very much enriched with osteocytes. The fourth isolated population (PC) was a mixed population of fibroblasts, osteoblasts, and preosteoblasts. On exposure to parathyroid hormone (PTH), all four cell populations showed increased lactate production, but only the OB and OC populations displayed increased cAMP production. Prostaglandin E1 (PGE1) stimulated cAMP production in both OB and PF cells. From the results of this study it was concluded that PTH receptors are present on all of the cell types studied, but that occupancy of the receptor induces adenylate cyclase stimulation only in osteocytes and fully differentiated osteoblasts.
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  • 34
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 33 (1981), S. 119-124 
    ISSN: 1432-0827
    Schlagwort(e): Avian eggshell ; Microstructure ; Electron microscopy ; Electron diffraction ; Calcite growth
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The eggshell of the domestic fowl has been studied by transmission electron microscopy and diffraction. Thin sections of shell were prepared by chemical and ion-beam thinning techniques. Each calcite column of the palisade layer consisted of crystallites of diameter 20 to 30 µm with some tendency for crystallite alignment within a single column. Evidence indicates that there was no significant preferred orientation in the palisade layer as a whole. Only in the surface layer was any preferred orientation detected, and here {1014} planes tended to lie parallel to the surface. The results are compared with previously published data, and calcite nucleation and growth are discussed.
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  • 35
    Digitale Medien
    Digitale Medien
    Springer
    International archives of occupational and environmental health 48 (1981), S. 147-157 
    ISSN: 1432-1246
    Schlagwort(e): Diesel exhaust emission ; Liver ; Electron microscopy ; Freeze-fracture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The livers of Syrian golden hamsters were examined with the light and electron microscope using the techniques of thin sectioning and freeze-fracture following 5 months of exposure to various concentrations of diluted diesel exhaust gases. The light microscopical examination showed enlarged sinusoides with activated Kupffer's cells and slight changes in the cell nuclei. In the electron microscopical examination the most striking changes were seen in the mitochondria, which frequently showed a loss in cristae. In addition, the mitochondria exhibited pleomorphic character. The microbodies were of the same size as mitochondria. An increase in the number of lysosomes was observed especially in the tissue surrounding the narrow bile canaliculi. The various alterations corresponding to the different concentrations of exhaust gases could be seen especially well in the sinusoides, the mitochondria and the microbodies. In general the hepatocytes appeared to be moderately enlarged. The zonulae occludentes showed a more irregular outline and large maculae tight junctions were found on the lateral region of the plasmalemma of hepatocytes. The gap junctions exhibited a wide range of structural diversity. The intramembranous particles on the P fracture face of the plasmalemma of hepatocytes are aggregated.
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  • 36
    ISSN: 1432-1106
    Schlagwort(e): Cat-spinocervical tract cells ; Intracellular staining ; Electron microscopy ; Synaptic vesicles
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Synaptic vesicles in initial collateral terminals of two feline Spinocervical tract cells have been investigated after intracellular staining with horseradish peroxidase. A total of 5325 vesicles in 52 axodendritic and 26 axo-somatic terminals were analysed after aldehyde-osmium fixation. The greatest length and longest perpendicular width of each vesicle were measured, and the ratio and geometric mean of the diameters (gm-diameters) were calculated. The vesicles were divided into classes with round, elliptical and flat organelles. The variations in vesicle length, gm-diameter, and diameter ratio were statistically analysed by means of one- and two-way analyses of variance and t-tests. The diameter ratio, the length of round vesicles, and the gm-diameters of round and elliptical vesicles differed significantly between the cells. The length and gm-diameter of the elliptical vesicles differed significantly between the groups of axo-dendritic and axo-somatic terminals of each cell. Round vesicles were significantly longer in the axosomatic than in the axo-dendritic terminals of each cell, and the gm-diameter showed this relation for both round and elliptical vesicles. It is assumed that a one-size vesicle could not account for all the measured profiles. The variability of synaptic vesicles within and between the functionally similar cells emphasize the difficulties in using the morphology of synaptic vesicles for a discrimination of axon terminals of different origin.
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  • 37
    Digitale Medien
    Digitale Medien
    Springer
    European biophysics journal 7 (1981), S. 209-212 
    ISSN: 1432-1017
    Schlagwort(e): Photosynthetic bacteria ; Electron microscopy ; Planar lattices
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Physik
    Notizen: Abstract The thylakoids of Rhodopseudomonas viridis have been studied by freeze-fracturing whole cells. Depending on growth conditions and treatment before freezing, three different types of particle arrangements in the photosynthetic membrane are reported: a random arrangement, an isometric (quadratic) lattice arrangement with a lattice constant of 12.5 ± 0.8 nm, and a hexagonal lattice arrangement with a lattice constant of 12.5 ± 0.8 nm.
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  • 38
    Digitale Medien
    Digitale Medien
    Springer
    Archives of toxicology 47 (1981), S. 101-111 
    ISSN: 1432-0738
    Schlagwort(e): Cerebellar cortex ; Methylmercury ; Toxicity ; Rat ; Morphometry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180–200 g). This resulted in brain levels of 1.4–2.2 μg Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pronounced in the cerebellar hemispheres than in the vermais and flocculus. At 7 days after giving the methylmercury the granule cells appeared to have returned to normal. Methylmercury produced both light and electron microscopic changes in cerebellar neurons of adult (180–200 g) rats 3 days after dosing. 2.5–10% of the granule cells appeared dark and condensed in toluidine blue stained semithin sections of perfusion fixed and plastic embedded material. In control animals the comparable percentage never exceeded 1. By electron microscopic morphometry the dark cells proved to be shrunken to 70%, whereas the remaining light granule cells were swollen to 130% of the normal cell volume. The heterochromatin and mitochondrial volumes per cell remained constant in both dark and light cells from methylmercury treated animals. In the Purkinje cells from both young and adult rats, geometrical changes in the cisternae of the granulated endoplasmic reticulum were evident. The swelling and shrinkage of the granule cells is supposed to be due to impaired electrolyte control and the disorganized granulated endoplasmic reticulum of the Purkinje cells may be related to the deleterious effects on protein synthesis.
    Materialart: Digitale Medien
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  • 39
    Digitale Medien
    Digitale Medien
    Springer
    Journal of neurology 225 (1981), S. 67-72 
    ISSN: 1432-1459
    Schlagwort(e): Ewing sarcoma ; Epidural tumors ; Spinal cord compression ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird ein Ewing-Sarcom, welches sich außerhalb des Skelettes bei einem Kind entwickelte, geschildert. Klinisch manifestierte es sich als epidurale Masse. Bei der chirurgischen Exploration zeigte sich ein brüchiges Gewebe, welches 2–3 cm lang war und nicht vom Knochen ausging. Lichtmikroskopisch und elektronenmikroskopisch ließ sich die Diagnose eines Ewing-Sarcoms stellen. Es werden morphologische Aspekte und differentialdiagnostische Überlegungen in Zusammenhang mit Tumoren des Epiduralraumes diskutiert.
    Notizen: Summary The clinicopathological findings in a child with extraskeletal Ewing sarcoma are described. The patient complained of pain in the lower back and difficulty walking. An extraskeletal, epidural, friable tumor, 2–3 cm long was removed from the epidural space. It had no relationship with the bone structures. Light and electron microscopic examination of the tumor led to the diagnosis of Ewing sarcoma. The morphological aspects of this neoplasia and the problem of the differential diagnosis with other small cell tumors of the epidural space are discussed.
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  • 40
    Digitale Medien
    Digitale Medien
    Springer
    Journal of neurology 224 (1981), S. 171-182 
    ISSN: 1432-1459
    Schlagwort(e): Cerebral amyloidoma ; Congo red birefringence ; IgM immunofluorescence ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Eine fast walnußgroße, intra- und subcortical gelegene Masse von Congo-Rot-färbbarem Amyloid mit einigen umgebenden Lympho-Monozyten, Plasmazellen und mehrkernigen Elementen sowie doppelbrechenden plumpen Plaques und fein dispers verteilten Amyloidpräzipitaten innerhalb eines unmittelbar angrenzenden kleinen Rinden-Restgewebes wurde operativ aus dem Occipitallappen entfernt. Aufgrund der typischen grüngelblichen Doppelbrechung im Congo-Rot-Präparat, der Thioflavin-Fluoreszenz, der positiven PAS-Reaktion, Bindegewebsfaserfärbungen und des elektronenmikroskopischen Nachweises charakteristischer unverzweigter 10 nm-Fibrillen kann die Diagnose eines cerebralen Amyloidtumors (Amyloidom) gestellt werden. Bei nur schwacher Anfärbung des vielfach deutlich appositionell gewachsenen Substrates mit Anti-Bence-Jones-Proteinserum (λ-Kette) reagierten die Perikarya der mononukleären lymphoiden Zellen und der Plasmocyten im indirekten Immunfluoreszenztest besonders mit Anti-IgM (FITC-markiert). — Die Trägerin, eine 46jährige Hausfrau, hatte jahrelang recidivierende depressive Episoden und in den letzten 4 Jahren fortschreitende neurologische Symptome nach Art eines chronischen raumfordernden Prozesses ohne jegliche Anzeichen einer Systemerkrankung oder Gammopathie. Sie erholte sich nach der Operation ziemlich gut. Es wird angenommen, daß es sich — analog zum tumorförmigen Amyloid in Haut, Lunge oder anderen Organen — hier um eine isolierte cerebrale Form von Paramyloid oder nodulärer primärer Amyloidose (Amyloid L) im Sinne von Reimann et al. (1935), Cohen (1967), Azar (1973), Langer und Missmahl (1980), Glenner (1980) u. a. handelt.
    Notizen: Summary An almost walnut-sized tumor was removed surgically from the left occipital lobe of a 46-year-old woman, who had suffered for 4 years from progressive visual loss with scotoma and finally from hemianopia, associated with attacks of headaches and recurrent episodes of depression each lasting for some weeks or months. Neuropathological examination, including polarization, thioflavine fluorescence, immunofluorescence staining, and electron microscopy, revealed an amyloidoma, which consisted of broad appositionally grown amyloid deposits surrounded by some plasma cells, monocytic or foreign body cell types. The massive accumulations, often associated not only with blood vessels or perivascular collagenous fibers but also lying in the cerebral tissue not unlike senile plaques in the cortical gray matter, corresponded to gradually growing masses as seen in the repeated CT scans. This unique lesion in the brain of a patient who did not show any evidence of systemic disorder, seems to confirm that the spontaneous tumor-like amyloid, which gave an immunofluorescent staining mainly with anti-IgM, is a special variant of primary amyloidosis (amyloid L) or of so-called paramyloid (Reimann et al. 1935; Cohen 1967; Azar 1973; Langer and Missmahl 1980).
    Materialart: Digitale Medien
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  • 41
    Digitale Medien
    Digitale Medien
    Springer
    Archives of microbiology 130 (1981), S. 125-128 
    ISSN: 1432-072X
    Schlagwort(e): Rhodospirillum rubrum ; Chromatophores ; Reaction centers ; Liposomes ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract In freeze-fractures of chromatophores of Rhodospirillum rubrum the reaction centers are seen as hexagonal arranged particles of 13 nm diameter with a density of around 5,500 particles per μm2. Similar regions on the cytoplasmic membrane suggest that these parts are the prospective invagination sites. Isolated reaction centers are easily incorporated into liposomes. In freeze fractures of liposomes particles similar in shape and size, although less dense as in chromatophores are observed. In negative staining much smaller units of only 5 nm in diameter are found indicating that reaction centers occur in the membrane as tri- or tetramers. There is a strong correlation between particle density in chromatophores and titratable reaction centers remaining in these membranes after extraction of reaction centers by detergents; both values are in good agreement with the yield of reaction centers at a given detergent concentration.
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  • 42
    Digitale Medien
    Digitale Medien
    Springer
    Archives of microbiology 129 (1981), S. 129-134 
    ISSN: 1432-072X
    Schlagwort(e): Cockroach ; Hindgut ; Distribution ; Microbial morphotypes ; Transmission ; Electron microscopy ; Statistical analysis ; Eublaberus posticus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The relative numbers of fourteen microbial morphotypes in transmission electron micrographs of the hindgut of a cockroach, Eublaberus posticus, were counted and their distribution was analyzed statistically. The microbiota of three wall-associated regions (the anterior paunch, the posterior paunch, and the black band region) was clearly different from that of the gut lumen. The three wall fractions were also significantly different from each other. Only one of the fourteen types, prosthecate bacteria, appeared to be distributed randomly in the four fractions. The five main wall-associated morphotypes individually constituted up to 41% of the microbes in some micrographs. They included one type with the characteristic morphology of Methanospirillum. Six morphotypes rarely made up over 2% of the population, but were consistently present. The numbers of the remaining three morphotypes were quite variable between micrographs and between individual insects, but when present often made up 5–10% of the population.
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  • 43
    Digitale Medien
    Digitale Medien
    Springer
    Archives of microbiology 129 (1981), S. 285-294 
    ISSN: 1432-072X
    Schlagwort(e): Biological control ; Cyanobacteria ; Electron microscopy ; Entrapment ; lysis ; Myxococcus ; Phormidium ; Spherule
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A Myxococcus xanthus isolate from a farm drainage ditch, designated strain PCO2, is capable of rapidly inducing lysis of both agar and liquid-grown cultures of the cyanobacterium, Phormidium luridum, var. olivacea. Microscopic studies of the predator-prey interaction demonstrate that lysis of the cyanobacterium occurs within clumps and spherules formed by the cells of M. xanthus PCO2. In the earliest stage, one sees the formation of irregular microclumps of bacteria and cyanobacterial filaments. As these clumps mature, colonies 1 to 6 mm in diameter develops. The center of these densely green colonies contains cyanohacteria in various stages of degradation, while the periphery is almost exclusively a tightly woven mass of myxobacterial cells. Electron microscopy shows that long extrusions from the outer membrane of the M. xanthus PCO2 cells are involved in the formation both of initial clumps and of mature colonial spherules. These extrusions appear to efficiently entangle the cyanobacterial filaments in the culture environment. Predator-to-prey ratios of 1/10, 1/100 and 1/1,000 have resulted in cyanobacterial lysis. Because the entrapment and lysis of P. luridum filaments by M. xanthus PCO2 appears to be independent of any other heterotrophic nutritional requirement, as well as of environmental agitation, this system has potential as a biological control technique for undesirable aquatic cyanobacteria.
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  • 44
    Digitale Medien
    Digitale Medien
    Springer
    Archives of microbiology 130 (1981), S. 339-343 
    ISSN: 1432-072X
    Schlagwort(e): Leptospira ; Halophilic ; Electron microscopy ; X-ray analysis ; Inclusions ; Cytoplasmic tubules
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The morphology of cells of strain Muggia, a slightly halophilic leptospire, was examined by the negative staining technique. The ultrastructure of the cells was rather similar to that of cells of Leptonema illini, i. e. the cells possessed cytoplasmic tubules. The basal complex of their flagella, however, was similar to the corresponding part of flagella on Gramnegative bacteria. The interior of the cells was densely packed with inclusions, except for the two outermost wavelengths at each end where these inclusions were absent. X-ray microanalysis showed that the inclusions contained sodium and chlorine as their main constituents. The inclusions disappeared upon storage of the cultures at room temperature.
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  • 45
    ISSN: 1432-072X
    Schlagwort(e): Ribulose bisphosphate carboxylase ; Quaternary structure ; Molecular weight ; Electron microscopy ; Cyanobacteria ; Synechococcus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Ribulose bisphosphate (RuP2) carboxylase from the marme cyanobacterium, Synechococcus sp., comprised both large (57,000 dalton) and small (12,000 dalton) subunits. The undissociated, purified enzyme was considerably smaller than the spinach enzyme when compared by pore-gradient electrophoresis, gel filtration and density-gradient centrifugation. This suggested that the cyanobacterial enzyme might have a hexameric (L6S6) subunit structure, unlike the enzymes from spinach and many other organisms which are octamers (L8S8). However, the molecular weight of the Synechococcus enzyme was measured by equilibrium sedimentation and found to be 530,000, which is within the range observed for L8S8-type enzymes. Furthermore, electron microscopic studies of negatively stained preparations of both the native enzyme, and a preparation depleted of 87% of its small subunits by repeated mild-acid precipitation, revealed four-fold symmetry characteristic of an octameric, cubical structure. Synechococcus RuP2 carboxylase therefore must be an L8S8 octamer and its anomalous pore-penetration behaviour may be due to an asymmetric shape. Some support for the latter possibility was provided by electron miscoscopic observations of two different types of images which may be different views of the molecule in two planes.
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  • 46
    Digitale Medien
    Digitale Medien
    Springer
    Journal of cancer research and clinical oncology 100 (1981), S. 51-58 
    ISSN: 1432-1335
    Schlagwort(e): Electron microscopy ; Rat astrocytomas ; Dibutyryl cyclic AMP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two cloned rat astrocytoma cell lines, 36 B-10 and 40 A-2, maintained in vitro were treated with 1 mM dibutyryl cyclic AMP. This treatment induced arborization of cellular processes and rounding-up of cell bodies in both cell lines and was associated with increased microvillous development in 40 A-2. There were no detectable concomitant changes in either (a) the quantity or organization of microtubules or 80–100 nm microfilaments, or (b) the intensity of glial fibrillary acidic protein indirect immunofluorescence staining.
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  • 47
    ISSN: 1432-5233
    Schlagwort(e): Electron microscopy ; Glibenclamide ; Glucose oxidation ; Insulin biosynthesis ; Insulin secretion ; Islets of Langerhans ; Mitochondria ; Morphometry ; Tissue culture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to evaluate long-term effects of sulphonylureas on pancreatic islet structure and function, isolated mouse islets were maintained in tissue culture for one week at various glucose concentrations, and in the absence or presence of glibenclamide. When the islets were cultured at 3.3 or 5.5 mmol/1, but not at 16.7 mmol/1 glucose, it was found that the drug stimulated insulin secretion into the culture medium during the initial 3 days of culture. During the remainder of the culture period no such enhancement of secretion was demonstrated. Insulin release due to glibenclamide apparently resulted in rapid depletion of intracellular insulin stores. The finding of an enlarged B-cell Golgi apparatus in the drug-treated islets was probably associated with granule discharge. The failure of glibenclamide to promote insulin secretion during the whole culture period could reflect the adverse effects of the drug on islet insulin biosynthesis as indicated by short-term experiments performed after culture. Similar experiments showed that the impaired insulin biosynthesis could not be restored by withdrawal of the drug from the culture medium for 3 days. Furthermore, the capacity for insulin release in response to an acute glucose challenge at the end of the culture period, was abolished by culture in the presence of glibenclamide. The drug effects on insulin biosynthesis and intracellular insulin stores, which were most pronounced at 5.5 mmol/1 glucose, possibly resulted from changes in B-cell metabolism as suggested by the diminished islet glucose-oxidation rate. The spatial characteristics of islet mitochondria indicated that these changes might involve an adaptation to substrates other than glucose. In conclusion, our findings suggest that sulphonylureas have an insulinotropic effect, which is however transient. Indeed, it rather seems as if long-term exposure of islet B-cells to sulphonylureasin vitro were accompanied by functional deficiency.
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  • 48
    ISSN: 1432-2307
    Schlagwort(e): Electron microscopy ; Effect of various GAG on fibril formation in vitro ; Collagen structure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Proteoglycans (PG) and glycosaminoglycans (GAG) bind to collagen, and thus influence fibril formation. Polysaccharides interfere with the aggregation of collagen molecules and affect pattern formation. The morphological structure of type I and type II collagen was studied after adding different GAG to collagen solutions in test tubes in vitro. Electron microscopical investigations suggest that sulfated GAG change the aggregation behaviour of collagen molecules. Thus, the cross-striation pattern is changed. This effect seems to be based on the degree of sulfatation and not on the molecular weight of the GAG. Furthermore, GAG appear to have a stabilizing influence on the in vitro fibril formation.
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  • 49
    ISSN: 1432-2307
    Schlagwort(e): Endocrine tumour ; Pancreas ; Argentaffin reaction ; Immunocytochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An endocrine pancreatic tumour that had not caused any endocrine symptoms was examined by histological, immunocytochemical and electron microscopic techniques. The majority of the tumour cells were argentaffin and contained secretory granules of the enterochromaffin cell type. Immunocytochemically a minority of tumour cells reacted to antisera against β-endorphin, met- and leu-enkephalin, gastrin, somatostatin and ACTH. The tumour was thus multihormonal, and appeared to be more closely related to the classic Carcinoid tumours of the mid-gut than to most pancreatic endocrine tumours.
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  • 50
    ISSN: 1432-0878
    Schlagwort(e): Pancreatic islets ; Adrenergic innervation ; Insulin secretion ; Chemical sympathectomy ; Adrenalectomy ; Fluorescence histochemistry ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Morphological changes in the adrenergic innervation of pancreatic islets after chemical sympathectomy by use of 6-hydroxydopamine and the influence of the sympatho-adrenal system on insulin secretion were investigated in the mouse and rat. Fluorescence histochemistry revealed a clear-cut reduction in the number of adrenergic nerve fibers in the pancreatic islets 2 days after administration of 6-hydroxydopamine; the reduction was more pronounced in the rat than in the mouse. In the rat, a partial regeneration was seen after 6 weeks. In the pancreas of the mouse, after administration of 6-hydroxydopamine, a severe damage of unmyelinated nerve fibers was revealed electron microscopically. However, no ultrastructural or immunohistochemical alterations could be demonstrated in the endocrine cells of the islets. 6-Hydroxydopamine induced a depression of basal plasma insulin concentrations in mice and an elevation in rats. Adrenalectomy depressed basal plasma insulin levels in mice. The α-adrenoceptor antagonist phentolamine enhanced insulin secretion in normal mice. The secretory response of insulin to phentolamine was diminished by chemical sympathectomy and almost abolished by adrenalectomy or the combination of chemical sympathectomy and adrenalectomy. Thus, the effect of phentolamine is probably mediated by liberated catecholamines. It is concluded that basal insulin secretion is partially regulated by the sympatho-adrenal system and that species differences exist in this respect. In addition, the results suggest that endogenous catecholamines have the ability to promote insulin secretion.
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  • 51
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 216 (1981), S. 471-479 
    ISSN: 1432-0878
    Schlagwort(e): Ovulation ; Perfusion ; Graafian follicle (Rabbit) ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary In the present investigation the ultrastructure of isolated rabbit ovaries, perfused with different media for various time periods, was studied. The steroid hormone production by the perfused ovary was also determined. Perfusion with Medium 199 results in prominent interstitial ovarian oedema which increases with perfusion time. Even after the addition of 6–10 % Dextran T40, oedema appears in the interstitial tissue of the ovary. Perfusion solutions with osmotically active colloid particles of large molecular size (Dextran T70; average molecular weight 70,000 and bovine serum albumin), cause less distortion in the ovarian structure, and ultrastructurally the ovarian tissues appear essentially the same as in the control ovaries. The results indicate that the perfused rabbit ovary, under strictly controlled conditions, can be used as an experimental model for studies of various aspects of ovarian function, including follicular rupture.
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  • 52
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 216 (1981), S. 205-214 
    ISSN: 1432-0878
    Schlagwort(e): Compound eyes ; Insects ; Crustaceans ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The basement membrane of the compound eye of four insect species and three crustacean species was investigated employing electron microscopy. The basement membrane consists of an extracellular (basal lamina) and a cellular portion, the latter being composed of the flattened terminal extensions of cone cells and accessory pigment cells in insects and distal pigment cells in crustaceans. Other cells can also contribute to the basement membrane. It is thus a complex structure in all well-developed compound eyes. The cellular contributions vary in different species and were found to correlate to specific taxonomic units.
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  • 53
    ISSN: 1432-0878
    Schlagwort(e): Gastrin ; CCK ; Median eminence ; Electron microscopy ; Xenopus laevis (Amphibia, Anura)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary By use of an anti-gastrin serum and colloidal gold- or ferritin-labelled sheep anti-rabbit γ-globulins, nerve fibres and nerve terminals containing a gastrin-like substance were characterized at the ultrastructural level in the median eminence of Xenopus laevis. These immunoreactive fibres contain neurosecretory granules displaying medium to high electron density and a mean diameter of 75 nm. Labelling intensity varies from granule to granule. This is the first demonstration at the ultrastructural level of the precise location of a gastrin-like hormone in the median eminence of a vertebrate.
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  • 54
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 217 (1981), S. 211-223 
    ISSN: 1432-0878
    Schlagwort(e): Pituitary gland ; Pars intermedia ; Electron microscopy ; Sheep
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Light microscopy of coronal sections of the sheep pars intermedia revealed a compact, incompletely lobulated V-shaped region about 15–20 cells thick, situated between the pars distalis and the pars nervosa. A prominent hypophysial cleft and follicles containing a colloid-like substance were seen. Using electron microscopy, five cell types could be distinguished: pars intermedia glandular cells, pars distalis-like glandular cells, interstitial cells, follicular cells and cleft lining cells. The polyhedral to pear-shaped pars intermedia glandular cells predominated. They contained dense-cored, membrane-bound granules near the Golgi complex, and larger, irregular vesicles with finely granular contents of varying electron density throughout the remaining cytoplasm; exocytotic release of granules was occasionally observed. Smaller numbers of cells resembling those seen in the pars distalis were scattered throughout the pars intermedia. Interstitial cells usually possessed elongated cytoplasmic processes which extended between the glandular cells, and were characterized by deeply indented nuclei, elaborate junctional complexes and an absence of cytoplasmic granules. Cells lining the follicles resembled the interstitial cells. The major cells bordering the hypophysial cleft were triangular in section and bore irregular microvilli on their free surface. The pars intermedia appeared to be less vascular than the remainder of the hypophysis and only occasional fenestrated capillaries were seen. Nerve profiles were rare.
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  • 55
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 215 (1981), S. 643-649 
    ISSN: 1432-0878
    Schlagwort(e): T-lymphocytes ; Blast cells ; Autoradiography ; Electron microscopy ; Stereology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary As a companion to an earlier study, the morphometric attributes of stimulated (blast-derived) lymphocytes in mouse axillary lymph nodes have been established using stereological and autoradiographic methods. Blast transformation was induced in vivo with dinitrochlorobenzene (DNCB) and stimulated cells were labelled with tritiated thymidine. Random samples of cells were taken for light and electron microscopic morphometry. In comparison to the unstimulated lymphocyte, the stimulated cell increased in size and possessed a greater plasma membrane surface area. Increase in cell size was the result of increases in the volumes of all measured subcellular compartments both in the nucleus and the cytoplasm. Heterogeneity of the stimulated cell population precludes firm conclusions regarding the significance of all these ultrastructural changes, though alterations in cell surface are discussed in the context of known biochemical differences accompanying blastogenesis.
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  • 56
    Digitale Medien
    Digitale Medien
    Springer
    Cell & tissue research 216 (1981), S. 557-568 
    ISSN: 1432-0878
    Schlagwort(e): Electron microscopy ; Neuroglia ; Silver impregnation ; Brain ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The silver-impregnation procedure of Tsujiyama is suitable for demonstration of all three classical types of neuroglial cells; in the present study it was used for electron microscopic identification of neuroglial cells in the brain of the cat. The aim of the present study was 1) to determine impregnated structural correlates of neuroglial cells at the light- and electron-microscopic levels, and 2) to determine whether the method of Tsujiyama is applicable for the electron microscopic identification of the single types of neuroglial cells. Silver deposits were observed over the cytoplasm and processes of astrocytes where numerous glial filaments were present. Oligodendrocytes and microglial cells may be precisely differentiated by use of Tsujiyama's silver impregnation method at the electron microscopic level due to the pattern of silver-deposition in these two basic types of cells. This silver-impregnation method combined with electron microscopy is thus suitable for a precise identification of neuroglial cells; the technique may prove to be very helpful in identification of such categories of neuroglial cells that encompass also the images of cells which cannot be classified by use of the standard methods.
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  • 57
    Digitale Medien
    Digitale Medien
    Springer
    European archives of oto-rhino-laryngology and head & neck 233 (1981), S. 271-300 
    ISSN: 1434-4726
    Schlagwort(e): Neurogenic sarcoma ; Neurofibrosarcoma ; Malignant schwannoma ; Head and neck ; Tumors of the peripheral nervous system ; Histopathology ; Electron microscopy ; Differential diagnosis ; Case reports ; Computerized X-ray-tomography ; Prognosis ; Therapy ; Neurogenes Sarkom ; Neurofibrosarkom ; Malignes Schwannom ; Kopf- und Halsbereich ; Tumoren des peripheren ; Nervensystems ; Histopathologie ; Elektronenmikroskopie ; Differentialdiagnose ; Fallberichte ; Computertomografie ; Prognose ; Therapie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Das neurogene Sarkom ist ein insgesamt seltenes malignes Neoplasma, das sich von den Hüllen des peripheren Nerven ableitet. Entwickelt sich diese Geschwulst aus einem solitären oder multiplen Neurofibrom, so wäre nomenklatorisch auch die Bezeichnung Neurofibrosarkom gerechtfertigt, während alle anderen Synonyma für diese Geschwulst, insbesondere das maligne Schwannom, aus histogenetischen Gründen verlassen werden sollten. Für die Klassifizierung aller Tumoren des peripheren Nervensystems ist heute ein von der WHO (1969) akzeptierter Vorschlag zugrunde zu legen. Ein tabellarischer Literaturüberblick zeigt, daß in den letzten 50 Jahren nur über wenig mehr als 100 Fälle von neurogenen Sarkomen im Kopf-Halsbereich berichtet wurde. Die Differentialdiagnose dieses malignen Tumors umfaßt nahezu alle anderen malignen Weichgewebsgeschwülste und manchmal sogar ein anaplastisches Karzinom. Die Histopathologie, einschließlich der Elektronenmikroskopie, wird allgemein und an drei eingehenden Falldemonstrationen aufgezeigt, wobei auch den drei mikromorphologischen Varianten Rechnung getragen wird. Neben der feingeweblichen Untersuchung, die nur beim zusätzlichen Vorliegen einer Neurofibromatose oder bei der Identifizierung des Ursprungsnerven hundertprozentig gesichert werden kann, sind konventionelle und computertomografische Röntgentechniken zur Diagnosestellung hilfreich. Zum Schluß werden die Grundsätze der Therapie sowie die Prognose diskutiert.
    Notizen: Summary The neurogenic sarcoma is a neoplasm found seldom. It descends from the sheaths of peripheric nerves. If this tumor develops from a solitary or multiple neurofibroma, it might also be called a neurofibrosarcoma. All other synonyms, especially that of the malignant schwannoma, should better be abandoned for histogenetic reasons. Today the classification of all tumors of the peripheral nervous system is based on a suggestion of the WHO from 1969. The tabular summary of the literature shows that only a little more than a hundred cases of neurogenic sarcoma of the head and neck were reported during the last 50 years. Differential diagnosis of this malignant tumor includes nearly all other malignant neoplasms of soft tissue, sometimes even anaplastic carcinoma. Histopathology, including electron microscopy, is described in general and also in detail with regard to three cases. Three forms of micro-morphological variants are dealt with, too. For diagnosis histological examination will be absolutely successful only in cases of neurofibromatosis or in cases where the nerve from which the tumor originates may be identified. Otherwise, conventional and computerized X-ray tomography may be helpful. Finally, some therapeutic and prognostic principles are discussed.
    Materialart: Digitale Medien
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  • 58
    Digitale Medien
    Digitale Medien
    Springer
    European archives of oto-rhino-laryngology and head & neck 230 (1981), S. 161-170 
    ISSN: 1434-4726
    Schlagwort(e): Sudden deafness ; Vertigo ; Neurectomy ; Eighth nerve ; Light microscopy ; Electron microscopy ; Demyelinating disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A patient initially presenting typical symptoms of idiopathic sudden deafness later developed disabling episodic vertigo, which led to translabyrinthine eighth nerve transection. Morphological examination of the removed cochlear nerve specimen revealed a demyelinating process in the neuroglial portion of the nerve. The major part of the peripheral, neurolemmal portion of the cochlear nerve was normal. The inferior vestibular nerve was fibrotic. The major part of the superior vestibular nerve was normal. Some of its peripheral bundles showed increased endoneurial fibrosis. It is suggested that a demyelinating process was the cause of the patient's symptoms.
    Materialart: Digitale Medien
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  • 59
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3079-3101 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Building units for Oligosaccharides, XXIX. Synthesis of a Trisaccharide Chain of N-Acetylglucosamine, Galactose and Rhamnose of an O-Determinant from Escherichia coli. Dependence of Stereoselectivity of the α-Glycoside Synthesis on the Reactivity of the PyranosylhalideThe mercury salt catalysed reaction of substituted α-D-galactosyl halides with the reactive 4-OH groups of the rhamnosides 18 and 19 were studied. The order of reactivity of the halides increases with the following substituents: O-acetyl 〈 O-glucosyl 〈 O-benzyl. The order of selectivity, towards the α-glycoside, was the reverse. The selectivity can be improved by either decreasing the reactivity of the glycosyl halide, in the case of highly reactive hydroxyl groups, or by decreasing the nucleophilicity of the hydroxyl groups, in the case of highly reactive halides. Various trisaccharides, like 58 which represents the repeating-unit of the lipopolysaccharide from Escherichia coli O 75, were synthesized from N-acetylglucosamine, galactose and rhamnose.
    Notizen: Die Quecksilbersalz-katalysierte α-Glycosidsynthese von gemischt substituierten α-D-Galactosylhalogeniden mit den reaktiven 4-OH-Gruppen der Rhamnoside 18 und 19 wird untersucht. Die Reaktivität der Halogenide nimmt bei Anwesenheit der folgenden Substituenten zu: O-Acetyl 〈 O-Glycosyl 〈 O-Benzyl. Parallel dazu nehmen die Selektivität und der Anteil and α-Glycosid ab. Notwendige Selektivitätsverbesserungen können bei zu reaktiven OH-Gruppen durch Verminderung der Reaktivität des Glycosylhalogenids, bei zu reaktiven Glycosylhalogeniden durch Verminderung der Reaktivität der OH-Gruppe erzielt werden. Verschiedene Trisaccharideinheiten aus N-Acetylglucosamin, Galactose und Rhamnose werden synthetisiert, wobei 58 einer Teil-struktur der repeating-unit der O-Determinante des Lipopolysaccharids aus Escherichia coli O 75 entspricht.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
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  • 60
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3115-3125 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Building Units for Oligosaccharides, XXXI. Synthesis of the Repeating-Unit of the O-Specific Chain of the Lipopolysaccharide from Escherichia coli O 75Reaction of the trisaccharidehalide-block 12 with the benzyl rhamnoside 13 gave a tetrasaccharide which, after complete removal of the protecting groups, yielded the branched tetrasaccharid 1 (see german summary). This represents the repeating-unit of the O-specific chain of the lipopolysaccharide from Escherichia coli O 75. A simular reaction between the block 12 and the 8-ethoxycarbonyloctyl rhamnoside 19 leads to the tetrasaccharide 20 which contains a suitable spacer-unit for coupling with a protein to give a synthetic antigen.
    Notizen: Durch eine Synthese, bei der der Trisaccharidhalogenid-Block 12 verwendet wird, läßt sich nach vollständiger Entblockierung das verzweigte Tetrasaccharid erhalten, das die repeating-unit der O-spezifischen Kette des Bakteriums Escherichia coli O 75 darstellt. Durch Verknüpfung des Blocks 12 mit dem Rhamnosid 19, einem Glycosid des 8-Ethoxycarbonyloctanols, wurde das spacer-haltige Tetrasaccharid 20 synthetisiert. Dieses ist ein Hapten, das zur Anknüpfung an ein Protein und somit zur Gewinnung eines synthetischen Antigens geeignet ist.
    Materialart: Digitale Medien
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  • 61
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3549-3557 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Substituted Mononucleus Carbonyliron HydridesSubstitution of H2Fe(CO)4 by ligands like L = As(C6H5)3, Sb(C6H5)3 and P(OC6H5)3 in 1:1 ratio leads to fac monosubstituted compounds H2Fe(CO)3L. A 1:2 ratio results in the isolation of disubstituted complexes H2Fe(CO)2L2, L = P(OCH2)3CC2H5, P(OC6H5)3. The structure of H2Fe(CO)3As(C6H5)3 Was elucidated by X-ray analysis.
    Notizen: Substitution von H2Fe(CO)4 mit Liganden L = As(C6H5)3, Sb(C6H5)3 und P(OC6H5)3 im Molverhältnis 1:1 Führt zu fac-Monosubstitutionsverbindungen H2Fe(CO)3L. Im Verhältnis 1:2 können trans-Disubstitutionskomplexe H2Fe(CO)2L2, L = P(OCH2)3CC2H5, P(OC6H5)3, erhalten werden. Von H2Fe(CO)3As(C6H5)3 wurde eine Röntgenstrukturanalyse ausgeführt.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
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  • 62
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3518-3532 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Reactivity of the Silaethene Me2Si=C(SiMe3)2: Thermolysis of (Me3Si)2(Me2XSi)CLi (X e. g. (PhO)2PO2) in the Presence of Silaethene Trapping ReagentsSilaethene Me2Si=C(SiMe32 (1), generated as a reaction intermediate by the thermal elimination of LiX from Me2XSi—CLi(SiMe3)2, combines with the reactants a-b (e. g. Me3Si—Cl, Me3Si—OMe) with insertion in the a-b bond, with a = b-c-H (e. g. CH2=CMe—CH2—H) under ene-reaction and with (e. g. CH2=CR—CR=CH2, O=N=N, Ph2C=NSiMe3, Me3SiN=NSiMe3, PhC=N) under [2 +4]-, [2 + 3]- [2 + 2]- as well as [2 + 2 + 2]-Cycloaddition. Some of the cycloadducts, so obtained, are thermolabile and decompose under cycloreversion, which may lead to the formation of 1 and also to Me2Si=NSiMe3. The following order of relative reactivity of 1-trapping reagents has been found (formation of 1 at -10°C): Me3Si—NMe2 Me3Si—Cl 〈 PhC≡N 〈 1,3-butadien 〈 2.3-Dimethyl-1,3-butadien ≍ isobuten 〈 Me3Si—OMe 〈 Ph2C=NSiMe3 〈 PhN=NPh 〈 Me3SiN=NSin=NSiMe3 ≪ Ph2C=O, Me3SiN=N=N.
    Notizen: Das durch thermische LiX-Eliminierung aus Me2XSi—CLi(SiMe3)2 als Reaktionszwischenstufe erzeugbare Silaethen Me2Si=C(SiMe3)2 (1) reagiert mit Reaktanden a-b (z. B. Me3Si—Cl, Me3Si-OMe) unter Insertion in die a-b-Bindung, mit a = b-c-H (z. B. CH2 CMe—CH2—H) unter En-Reaktion und mit (z. B. CH2=CR—CR=CH2, O=N=N, Ph2C=NSiMe3, Me3SiN=NSiMe3, PhC≡N) unter [2 +4]-, [2+3]-[2 + 2]- sowie [2 + 2 + 2]-Cycloaddition ab. Die erhaltenen Cycloaddukte sind zum Teil thermolabil und zerfallen unter Cycloreversion u. a. unter Bildung von 1 sowie auch Me2Si=NSiMe3. Folgende Reihe relativer Reaktivitäten von 1-Fängern wurde gefunden (Erzeugung von 1 bei -10°C): Me3Si—NMe2 Me3Si—Cl 〈 PhC≡N 〈 1,3-Butadien 〈 2,3-Dimethyl-1,3-butadien ≍ Isobuten 〈 Me3Si—OMe 〈 Ph2C=NSiMe3 〈 PhN=NPh 〈 Me3SiN=NSiMe3 ≪ Ph2C=O, Me3Sin=N=N.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
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  • 63
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3533-3548 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Aliphatic Azo Compounds, XIII: cis- and trans-1-AzonorbornaneThe rates of isomerisation of cis-1-azonorbornane to the trans-isomer at 96.6°C in a series of aprotic solvents follow a linear correalation with ET30. The small slope of the correlation -0.034 argues for isomerisation via semilinearisation in agreement with theory. In protic solvents the isomerisation proceeds faster possibly due to a faster isomerisation by bond rotation which could be favoured by H-bonding. The heat and the activation parameters of the isomerisation and the activation parameters of thermal decomposition of trans-1-azonorbornane allow the construction of a complete enthalpy diagram of this system. The structure of cis-1-azonorbornane was determined by X-ray analysis at -60°C. The observed angle deformations and the normal NN-bond lengths are reproduced by force field calculations.
    Notizen: Die Isomerisierungsgeschwindigkeit von cis- in trans-1-Azonorbornan (1) folgt bei 96.6°C linear dem Polaritätsparameter ET30 in verschiedenen aprotischen Lösungsmitteln. Die geringe Steigung -0.034 dieser Korrelation deutet auf einen theoretisch vorgeschlagenen einfachen Inversionsmechanismus. In protischen Lösungsmitteln verläuft die Isomerisierung viel schneller, wofür ein durch H-Drücken begünstigter Rotationsmechanismus Möglich gehalten wird. Reaktionsenthalpie und Aktivierungsparameter der cis-trans-Isomerisierung und die Aktivierungsparameter der Thermolyse von trans-1-Azonorbornan gestatten die Aufstellung eines vollständigen Enthalpiediagramms. Die Struktur von cis-1 wurde durch Röntgenanalyse bei -60°C bestimmt. Die starke Winkeldeformation und der normale NN-Abstand im Kristall werden durch Kraftfeldrechnungen richtig wiedergegeben.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
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  • 64
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Metalcarbonyl Syntheses, X: Synthesis of New Niobium and Tantalum Halfsandwich Complexes. Molecular Structure of the Parent Compound (η5-C5H5)Nb(CO)4The halfsandwich complexes (η5-C5H4CH3)Nb(CO)4 (3a), [η5-C5(CH3)5]Nb(CO)4 (3b), (η5-C5H4CH3)Ta(CO)4 (3c), and [η5-C5(CH3)5]Ta(CO)4 (3d) are accessible by reductive high-pressure carbonylation of the corresponding NbV- and TaV precursors (η5-C5R4R′)MCl4 (2a-d). Successive introduction of methyl groups in the cyclopentadienyl ring facilitates the reduction of the halogeno complexes 2a-d; moreover, the niobium complexes are more susceptible to reduction than their tantalum counterparts. Upon photolysis of the carbonyl complexes 3a-d in tetrahydrofuran, the solvens complexes of type (η5-C5R4R′)M(CO)3(THF) (4a-d) are generated. The parent compound (η5-C5H5)Nb(CO)4 (1) has a regular square-pyramidal structure as shown by X-ray analysis.
    Notizen: Die Halbsandwich-Komplexe (η-5C5H4CH3)Nb(CO)4 (3a), [η5-C5(CH3)5]Nb(CO)4 (3b), (η5-C5H4CH3)Ta(CO)4 (3c) und [η5-C5(CH3)5]Ta(CO)4 (3d) sind durch reduzierende Hochdruckcarbonylierung der entsprechenden NbV-bzw. TaV-vorstufen (η5-C5R4R′)MCl4 (2a-d) synthetisierbar. Die Reduzierbarkeit der Halogeno-Komplexe, 2a-d, wird durch sukzessive Einführung von Methyl-Substituenten in den Cyclopentadienyl-Ring erleichtert und ist bei den Niob-Verbindungen mit milderen Reduktionsmitteln als bei den analogen Tantal-Komplexen möglich. Bei der Photolyse von 3a-d in Tetrahydrofuran entstehen die Solvens-Komplexe (η5-C5R4R′)M(CO)3(THF) (4a-d). Die Stammsubstanz (η5-C5H5)Nb(CO)4 (1) wurde röntgenstrukturanalytisch untersucht und besitzt eine unverzerrt tetragonal-pyramidale Molekülstruktur.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
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  • 65
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3572-3580 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Complexes of Germanium Dichloride with 1,2-Bis(diphenylphosphino)ethane: A Semi-Chelate and A Double-Ylide1,2-Bis(diphenylphosphino)ethane (dppe) reacts with the germanium dichloride dioxane complex depending on the stoichiometric ratio to give a 1:2 dppe-bridged bis(germylene) complex (1) or a 1:1 complex (2) that shows equilibration of both phosphorus atoms in 31P-NMR. The crystal structure of 2 has been determined from single crystal X-ray data. The compound crystallizes with 8 units dppe-GeCl2· 1/2 C6H6 in a unit cell of symmetry A 2/a-C2h6 in a monoclinic system. The dppe-GeCl2 molecules contain a novel semi-chelating type of coordination of the dppe ligand [distorted Ψ-trigonal bipyramidal coordination at Ge11 with an exceptionally long distance Ge-P(apical)]. 2 thus represents an intermediate structure between chelate complex and phosphorus ylid.
    Notizen: 1,2-Bis(diphenylphosphino)ethan (dppe) reagiert mit dem Germanium(II)-chlorid-Dioxankomplex je nach Mengenverhältnis zu einem dppe-verbrückten Bis(germylen)-Komplex (1) oder zu einem 1:1-Komplex (2), der sich durch die Äquivalenz der Phosphanfunktionen in Lösung (31PNMR) auszeichnet. 2 kristallisiert mit 1/2 C6H6 monoklin mit acht Einheiten der Formal dppe-GeCl2· 1/2 C6H6 in der Elementarzelle, Raumgruppe A 2/a-C2h6. Die verzerrt Ψ-trigonal-bipyramidale Koordination um Ge11 mit ungewöhnlich langem Abstand Ge-p(apikal) weist 2 als Komplex mit halb-chelierendem dppe-Liganden aus (Zwischenstellung zwischen Chelatkomplex und einfachem \documentclass{article}\pagestyle{empty}\begin{document}$ \mathop {\rm P}\limits^{\rm + } - \mathop {{\rm Ge}}\limits^{\rm - } - {\rm Ylid} $\end{document}).
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
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  • 66
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3581-3588 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Autoxidation of Trialkylboranes, II: 1H NMR Spectroscopic Investigations on the Mechanism of the Redox Reaction between Trialkylboranes und Dialkyl(alkylperoxy)boranesThe intermolecular redox reaction between dimethyl(methylperoxy)borane and [D9]trimethylborane, triethylborane, tri-n-propylborane, triisopropylborane, and tri-n-butylborane, as well as between [D9]dimethyl(methylperoxy)borane and trimethylborane was investigated directly in an NMR spectrometer. From the CIDNP effects a mechanism of this redox reaction was deduced, which can be considered as generally valid for any reaction between (alkylperoxy)boranes and alkylboranes. According to this mechanism, the alkoxy group of the peroxide is transferred to the boron atom of the alkylborane after homolysis of the O—O bond. The four-coordinate boron compound eliminates instantly an alkyl radical, which forms a radical pair in the singlet state with the boroxyle radical left after the homolysis of the peroxide.
    Notizen: Die intermolekularen Redoxreaktionen Zwischen Dimethyl(methylperoxy)boran und [D9]Trimethylboran, Triethylboran, Tri-n-propylboran, Triisopropylboran und Tri-n-butylboran sowie zwischen [D9]Dimethyl(methylperoxy)boran und Trimethylboran wurden in Lösung im 1H-NMR-Spektrometer untersucht. Aus den CIDNP-Effekten wird ein allgemeingültiger Mechanismus der Redoxreaktion zwischen (Alkylperoxy)boranen und Alkylboranen abgeleitet. Danach wird in einem Stoßkomplex zwischen (Alkylperoxy)boranen und Alkylboran durch Homolyse der O—O-Bindung gezielt die Alkoxygruppe des Peroxids auf das Boratom des Alkylborans übertragen. Das vierfach koordinierte Alkoxyalkylboran stößt sofort ein Alkyl-Radikal ab, welches mit dem Boroxylradikal aus der Spaltung des Peroxids zu einem Radikalpaar mit Singulett-Konfiguration der Radikalelektronen zusammenfindet.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
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  • 67
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3589-3598 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Highly Fluorinated Phosphorus Ylides and Phosphonium SaltsThe (perfluoroalkyl)iodophosphanes n-C6F13PI2 and (n-C6F13)2PI, obtained from n-C6F13I and white phosphorus at 235°C under pressure, are converted into the chlorides n-C6F13PCI2 and (n-C6F13)2PCl with HgCl2. The chlorides are methylated with LiCH3 to form the methylphosphanes n-C6F13P(CH3)2, (6) and CH3P(n-C6F13)2 (5), respectively. Only 6, but not 5, can be quaternized with CH3I to yield a phosphonium salt, [n-C6F13P(CH3)3]I (8). In reactions of 8 with strong bases no corresponding ylide is generated, but a phosphorane n-C6F13P(CH3)4 is obtained instead. More highly fluorinated phosphonium salts could not be prepared. - The Phosphanes (CH3)2PC6F5 (11) and CH3P(C6F5)2 (12) yield onium salts [(CH3)3PC6F5]X (13) and [(CH3)2P(C6F5)2]X (14), resp., when treated with methylating agents. P(C6F5)3 undergoes dearylation reactions under comparable conditions. 13 and 14 are transformed into dark red unstable ylides, which oligomerize with autocondensation and could not be identified. From 12 and C6F5CH2Br a red ylide 17 is obtained, via the onium salt 16, which can be isolated and characterized by spectroscopic data. Stable yellow ylides R3P=CHC6F5 (19a-c, R = CH3, i-C3H7, C6H5) are generated similarly from the phosphonium salts [R3PCH2C6F5]Br. Reduction of the carbanion nucleophilicity by the C6F5 groups appears to prevent autocondensation in these cases.
    Notizen: Die aus weißem Phosphor und n-C6F13I bei 235°C unter Druck dargestellten (Perfluoralkyl)iodphosphane n-C6F13PI2 und (n-C6F13)2PI werden mit HgCl2 in die Chloride n-C6F13PCl2 and (n-C6F13)2PCl umgewandelt und diese mit LiCH3 in die Methylphosphane n-C6F13P(CH3)2 (6) und CH3P(n-C6F13)2 (5) übergeführt. Von diesen ist nur 6 mit CH3I quartärisierbar. Das entstehende Salz [n-C6F13P(CH)3)3]I (8) ergibt mit starken Basen nicht das korrespondierende Ylid, sondern das Phosphoran n-C6F13P(CH3)4 (10). Höher fluorierte Phosphoniumsalze sind nicht zugänglich. - Die Phosphane (CH3)2PC6F5 (11) und CH3P(C6F5)2 (12) ergeben mit Methylierungsmitteln noch die Oniumsalze [(CH3)3PC6F5]X (13)bzw. [(CH3)2P(C6F5)2]X (14). P(C6F5)3 erleidet dagegen unter vergleichbaren Bedingungen eine Entarylierung. 13 und 14 werden von starken Basen in tief rote instabile Ylide übergeführt, die durch Autokondensation oligomerisieren und nicht faßbar sind. Mit C6F5CH2Br entsteht aber aus 12 über das Oniumsalz 16 ein rotes Ylid 17, das isoliert und spektroskopisch charakterisiert werden kann. Analog ergeben sich aus Salzen [R3PCH2C6F5]Br stabile gelbe Ylide R3P=CHC6F5 (19a-c, R = CH3, i-C3H7 und C6H5). Die Verminderung der Carbanion-Nucleophilie dieser Ylide durch die C6F5-Gruppe verhindert die Autokondensation.
    Materialart: Digitale Medien
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  • 68
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3609-3624 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Oxidative Additions to 2-Amino-4,4,5,5-tetrakis(trifluoromethyl)-1,3,2-dioxaphospholaneOxidative addition of HF, Cl2 and (CF3)2CO to the title compound 6 furnishes the phosphoranes 2, 9, and 3, respectively. In the case of NH4[OC(CF3)C(CF3)2OH] (4) the hydrospirophosphorane 1 is obtained via a substitution reaction followed by an oxidative addition. Compound 9 is a precursor for the aminotetraalkoxyphosphoranes 5, 8, and the very stable phosphazene 10 which is formed by loss of HCl by thermolysis. Due to a slow ligand exchange the 19F NMR spectrum of phosphorane 3 exhibits eight magnetically non equivalent CF3 groups. By means of 19F homodecoupling experiments extensive through space coupling is found in the molecule. The x-ray structure analysis of 3 shows a slight distortion from the trigonal bipyramidal geometry at phosphorus. For comparison, F2PNH2 and tBu2PNH2 react with (CF3)2 to form (CF3)2C=NH, the aminofluorophosphorane 11, F2P(=O)OCH(CF3)2 (13) bzw. von tBu2P(=o) (12) and tBu2P(=O)OCH(CF3)2 (14), respectively.
    Notizen: Durch oxidative Addition von HF, Cl2 und (CF3)2CO and die Titelverbindung 6 entstehen die Phosphorane 2, 9 und 3; mit NH4[OC(CF3)2C(CF3)2OH] (4) wird unter Abspaltung von NH3 und oxidativer Addition das Hydrophosphoran 1 erhalten. Durch Substitution von Chlor lassen sich aus 9 die Aminoalkoxyphosphorane 5 und 8 synthetisieren, während die Thermolyse unter HCl-Abspaltung zu dem äußerst beständigen Phosphazen 10 führt. Verbindung 3 zeigt im 19F-NMR-Spektrum wegen eingeschränkter dynamischer Prozesse acht magnetisch nicht äquivalente CF3-Gruppen. Durch 19F-Homoentkopplungsexperimente werden weitreichende Raumkopplungen nachgewiesen. Die Röntgenstrukturanalyse von 3 ergibt eine annähernd trigonal-bipyramidale Koordination des Phosphors, F2PNH2 und tBu2PNH2, zur vergleichenden Betrachtung herangezogen, reagieren mit Hexafluoraceton unter Bildung von (CF3)2C=NH sowie des Amino-fluorphosphorans 11 und des Phosphorsäureesters F2P(=O)OCH(CF3)2 (13) bzw. von tBu2P(=O)H (12) und tBu2P(=O)OCH(CF3)2 (14).
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
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  • 69
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3634-3642 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Au55[P(C6H5)3]12Cl6- a Gold Cluster of an Exceptional sizeThe reduction of (C6H5)3PAuCl with B2H6 in benzene yields Au9,2[P(C6H5)3]2Cl which is characterized by means of molecular weight determinations as Au55[P(C6H5)3]12Cl6. A simple model, based on an arrangement of close-packed gold atoms, leads to a gold cluster the structure of which is in good agreement with the unusual chemical composition. The Mößbauer spectrum of the compound shows four different kinds of gold atoms: a metallic part (Au13-nucleus), Au atoms coordinated by P(C6H5)3 and Cl ligands, resp., as well as uncoordinated surface gold. The complex can be decomposed by bromine and iodine to (C6H5)3PAuCl, (C6H5)3PAuBr(I), and metallic gold. The thermolysis at 50°C leads to [(C6H5)3P]2AuCl and gold quantitatively.
    Notizen: Die Reduktion von C6H5)3PAuCl mit B2H6 in Benzol ergibt Au9,2[P(C6H5)3]2Cl, das mittels Molmassebestimmungen als Au55[P(C6H5)3]12Cl6 charakterisiert wurde. Ein einfaches Modell, beruhend auf einer Anordnung dichtest gepackter Goldatome, führt zu einem Goldcluster, dessen Aufbau mit der ungewöhnlichen chemischen Zusammensetzung in guter Übereinstimmung ist. Das Mößbauer-Spektrum der Verbindung zeigt vier Sorten von Goldatomen: einen metallischen Anteil (Au13-Kern), durch P(C6H5)3-bzw. Cl-Liganden Koordinierte Au-Atome, sowie unkoordi-niertes Oberflächengold. Mit Brom und lod läß sich der Komplex zu (C6H5)3PAuCl, (C6H5)3 PAuBr(I) und metallischem Gold abbauen. Die Thermolyse bei 50°C führt quantitativ zu [(C6H5)3P]2AuCl und Gold.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
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  • 70
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3655-3666 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Cyanamidium Salts: Their Formation and Molecular StructureThe hexachloroantimonate 6a, is prepared by methylation of di-tert-butylcarbodiimide. According to an X-ray analysis, 6a is not a carbodiimidium salt 1) but a cyanamidium salt with C2ν symmetry of the molecular frame. the cyanamidium salts 6a - j, are prepared either by alkylation of carbodiimides1) or by alkylation of disubstituted cyanamides. Trisubstituted ureas or their thio analogues are not suitable starting materials for the preparation of compounds 6. Reactions of the cyanamidium salts 6 with HCl, water, and diethylamine are described.
    Notizen: Das durch Methylierung von Di-tert-butylcarbodiimid erhältliche Hexachloroantimonate 6a liegt nach einer Röntgenstrukturanalyse nicht als Carbodiimidium-1), sondern als Cyanamidiumsalz mit C2ν-Symmetrie des Molekülgerüstes vor. Die Cyanamidiumsalze 6a - j werden außer durch Alkylierung von Carbodiimiden 1) auch durch Alkylierung von disubstituierten Cyanamiden erhalten. Trisubstituierte Harnstoffe oder Thioharnstoffe sind keine geeigneten Ausgangsverbindungen zur Darstellung der salze 6. Es werden Umsetzungen der cyanamidiumsalze 6 mit HCl, Wasser und Diethylamin beschrieben.
    Zusätzliches Material: 1 Ill.
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  • 71
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3674-3683 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Transition metal Activated Organic compounds, X: Synthesis and Properties of all-α-Poly(N-methylpyrroles)all-α-Poly(N-methylpyrroles) with 2 - 6, 8 and 16 pyrrole units (2 - 8) were synthesized by lithiation of N-methylpyrrole, subsequent reaction with transition metal halides (best yields with NiCl2 as a rule) and repetitions of these processes. These compounds are surprisingly sensitive to heat and light.
    Notizen: all-α-Poly(N-methylpyrrole) mit 2 - 6, 8 und 16 Pyrroleinheiten (2 - 8) wurden durch Lithiierung von N-Methylpyrrol, Umsetzung mit Übergangsmetallhalogeniden (beste Ausbeute meist mit NiCl2) und Wiederholungen dieser Prozesse synthetisiert. Diese Verbindungen sind überraschend empfindlich gegen Hitze und Licht.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
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  • 72
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3667-3673 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Transition Metal Activated Organic Compounds, IX: Synthesis of Polyfurans by Organometallic Oxidative Coupling2,2′- (2a) and 3,3′-bifuran (3), hitherto only accessible by ring-forming syntheses in small yields, and the unknown compounds all-α-terfuran (2b) and all-α-quaterfuran (2c) have been prepared by convenient ring-Connecting syntheses in 85, 46, 16, or 53% yield, respectively. Lithiation of 2a and subsequent reacting with iodine afforded 5-iodo-2,2′-bifuran (6b, 46%). According to competition experiments acidity against n-butyllithium is increasing in the sequence furan 〈 2a, 〈 2b.
    Notizen: 2,2′ - (2a) und 3,3′-Bifuran (3), bisher nur durch ringbildende mehrstufige Synthesen in geringer Ausbeute zugänglich, sowie die noch nicht beschriebenen Verbindungen all-α-Terfuran (2b) und all-α-Quaterfuran (2c wurden durch leicht durchführbare ringverknüpfende Synthesen in 85, 46, 16 bzw. 53proz. Ausbeute erhalten. Lithiierung von 2a und Umsetzung mit Iod führte zu 5-Iod-2,2′-bifuran (6b. 46%). Durch Konkurrenzversuche wurde ansteigende Acidität gegen n-Butyllithium in der Reihe Furan 〈 2a 〈 2b festgestellt.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
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  • 73
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3684-3690 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Metal Hydrazides, XIX: Addition of Bis(diethylaluminio)-substituted Amidrazones and Carbohydrazides to NitrilesAmidrazones and carbohydrazides react with two equivalents of triethylaluminium to give bis (diethylaluminio) derivatives 1 and 7, respectively. In contrast to the corresponding mono(diethylaluminio)derivatives or disodium salts, these are capable of addition to nitriles with formation of N1-(aminomethylene)amidrazones(4; 81 - 95%) or N1-acylamidrazones (8 and 9; 56 - 85%), respectively.
    Notizen: Amidrazone und Carbohydrazide reagieren mit zwei Äquivalenten Triethylaluminium zu Bis(diethylaluminio)-Derivaten 1 bzw. 7, die sich anders als die entsprechenden Mono(diethylaluminio)-Derivate oder Dinatriumsalze glatt an Nitrile addieren. Man erhält N1-(Aminomethylen)amidrazone (4; 81 - 95%) bzw. N1-Acylamidrazone (8 und 9; 56 - 85%).
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
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  • 74
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3737-3739 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The Formation of Trichlorosulfonium (IV) Hexafluoroarsenate(V)Sulfur reacts with chlorine and arsenic Trifluoride under pressure to give [SCl3]+[AsF6]-. As an intermediate oxidizing substance [AsCI4]+ is identified by spectroscopy. Depolarization-Raman-spectra confirm the assignment made in literature.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
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  • 75
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Additions of Carboxylic Acid Dianions to α,β-Unsaturated Carbonyl Compounds - Control of the 1,2-/1,4-Regioselectivity by Steric substituent EffectsDilithium carboxylic acid dianions 1 attack α,β-unsaturated aldehydes (2) 1,2-regiospecifically with formation of the unsaturated β-hydroxy carboxylic acids 3/4. Additionally, the addition of the phenylacetate dianion 1a can be conducted to the threo-isomer with high selectivity by reversible reaction. - α,β-Enones (8) add 1 irreversibly in 1,2- and 1,4-position. Depending on the substitution pattern, the whole range from pure 1,2- to pure 1,4-adduct is covered. The influence of the 1-counterion M and of the solvent is significant; the 1,4-portion increases with the complexing effect of M and with the Lewis-basicity of the solvent.
    Notizen: Dilithiumcarbonsäure-Dianionen 1 addieren sich an α,β-ungesättigte Aldehyde (2) 1,2-regiospezifisch unter Bildung der γ,δ-ungesättigten β-Hydroxycarbonsäuren 3/4, wobei im falle des Phenylessigsäure-Dianions (1a)die Addition durch reversible Reaktionsführung zu hoher threo -Selektivität gesteuert werden kann. - α,β-Enone (8) nehmen 1 irreversibel in 1,2- und 1,4-Position auf, wobei nach Maßgabe der Substituenten das gesamte Spektrum von reinem 1,2- zu reinem 1,4-Addukt überstrichen wird. Bei gleichbleibendem Substitutionsmuster steigt der 1,4-Anteil mit der komplexierenden Wirkung der Gegenionen von 1 und mit der Lewis-Basizität des Solvens.
    Zusätzliches Material: 2 Ill.
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  • 76
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3725-3736 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Synthesis of Medium and Large Rings, II: Cyclodecenes and Cyclodecadienes with Functional Groups by Ring Expansion of CyclooctyneThe Diels-Alder adduct 1 from cyclooctyne and diethyl 3,4-furandicarboxylate gives by photolysis and subseqent thermolysis of the resulting oxaquadricyclane 2 the β,β′-bridged hexano-oxepin 3. Oxidative cleavage of one C=C double bond of 3 leads to the monocyclic cyclodecenone derivative 5 which can be converted to cyclodecadienes of the type 6 with an anellated butenolide ring. 6a - c, are chiral butadiene derivatives. 6a can be cleaved with acid or base to give the cyclodecenone 7 or the dicarboxylic acid 8.
    Notizen: Das Diels-Alder-Addukt 1 aus cyclooctin und 3,4-Furandicarbonsäure-diethylester liefert durch Photolyse und anschließende Thermolyse des Oxaquadricyclans 2 das β,β′-überbrückte hexanooxepin 3. Die oxidative Spaltung einer C=C-Doppelbindung von3 führt zum monocyclischen cyclodecenon 5, das sich zu Cyclodecadienen des Typs 6 mit anelliertem Butenolidring abwandeln läßt. 6a - c enthalten eine chirale Butadien-Struktur. Durch Keton- bzw. Säurespaltung von 6a erhält man das Cyclodecenon 7 bzw. die Dicarbonsäure 8. Mögliche Anwendungen des Verfahrens, das die Einführung von funktionellen Gruppen an vier benachbarten C-Atomen des Zehnringes erlaubt, werden besprochen.
    Materialart: Digitale Medien
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  • 77
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Linear Oligophosphaalkanes, III: Syntheses and stereochemistry of Palladium (II) Complexes of chiral Tetraphosphaalkanes H2-nRnP—[CH2]3 — PR′ — [CH2]m — PR′ — [CH2]3 — PRnH2-n(R, R′, = Me, tBu; m = 2, 3; n = 1, 2)The reaction of the chiral tetradentate ligands L of the title with K2PdCl4 affords the complexes Pd(L)Cl2 (2a - e), which for n = 1 may exist as ten (square pyramidal) or six (square planar coordination geometry) isomers. By suitable choice of the substituents R and size of the chelate rings (m + 3) the number of isomers may be reduced to two or three. The detailed investigation of the complexes 2a - e by means of 31P{1H} NMR spectroscopy offers the possibility to identify their stereochemistry. - Monodeprotonation of 2a (R = Me; m = 3; n = 1) and 2d (R = Me; m = 2; n = 1) by KOH or the OH- Form of anion exchange resin yields the phosphido complexes 3a and d (not isolated). Both compounds are oxidized by air with formation of the phosphanoxidophosphane complexes 4a and d, which exist as two or three configurational isomers with units Pd—P(O)Me—.
    Notizen: Die Umsetzung der im Titel genannten vierzähnigen Liganden L mit k2PdCl4 liefert die Komplexe Pd(L)Cl2(2a-e)w, die für n = 1 in Form von zehn (quadratisch pyramidale Ligandenanordnung) bzw. sechs (planare Koordinationsgeometrie) Konfigurationsisomeren vorliegen können. Durch geeignete Wahl der substituenten R und der Chelatringgröße (m + 3) läßt sich die Zahl der Isomeren auf zwei bzw. drei reduzieren. Die detaillierte 31P{1H}-NMR-spektroskopische Untersuchung der Komplexe 2a - e erlaubt die Identifizierung der Stereochemie der Isomeren. - Die durch Monodeprotonierung von 2a (R = Me; m = 3; n = 1) und 2d(R = Me; m = 2; n = 1) mit KOH oder der OH- -Form eines Anionentauschers gebildeten Phosphidokomplexe 3a and d werden durch Luftsauerstoff zu den phosphanoxidophosphan-komplexen 4a und d oxidiert, bei denen zwei bzw. drei Konfigurationsisomere mit P-gebundenen Phosphanoxido-Einheiten Pd—P(O)Me— vorliegen.
    Zusätzliches Material: 3 Ill.
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  • 78
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981) 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
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  • 79
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3599-3608 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Reactions with Aziridines (Aziranes), XXVI: Amine Catalyzed Amidoethylation of β-Dicarbonyl Compounds Simple Synthesis of 2-Methylpyrrole-1,3-dicarboxylateEsters of nonsubstituted and monosubstituted malonic, cyanoacetic, and β-keto acids are easily C-amidoethylated by N-acylaziridines in the presence of triethylamine. In this amine catalyzed reaction the acylaziridines show different degrees of reactivity. Often the products cannot be obtained by the known amidoethylation procedure or but in smaller yields. The new product 3g may smoothly be converted to the pyrroline 9 and further to the 2-methylpyrrole-1,3-dicarboxylate 10. - Divergent from earlier results, the primary amidoethylation product can be isolated from the known sodium salt reaction of tert-butyl acetoacetate with nonbulky acylaziridines. This product is cleaved by trifluoroacetic acid with remarkable easiness to yield the corresponding amidoethyl derivative of acetone.
    Notizen: Unsubstituierte und monosubstituierte Malonester, Cyanessigester und β-Ketoester werden in Gegenwart von Triethylamin durch N-Acylaziridine leicht am C amidoethyliert, dabei zeigt sich eine Reaktivitätsabstufung der N-Acylaziridine. Die Produkte sind oft durch die bisher bekannte Amidoethylierung nicht oder nicht in so guten Ausbeuten zugänglich. Das neue Produkt 3g läßt sich glatt zum Pyrrolin 9 und weiter zum 2-Methylpyrrol-1,3-dicarbonester 10 umwandeln. - Abweichend von bisherigen Ergebnissen kann man aus Acetessigsäure-tert-butylester nach der bekannten Natriumsalzmethode auch mit nichtsperrigen Acylaziridinen das Primärprodukt fassen, das mit Trifluoressigsäure bemerkenswert leicht zum entsprechenden Amidoethylderivat des Acetons gespalten wird.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
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  • 80
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3643-3654 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Electrochemical Syntheses, XVIII: Reactions of the Radical Cation of Naphthalene with NucleophilesSolid naphthalene radical cation hexafluorophosphate at -77°C reacts with tetrabutylammonium cyanide, acetate, thiocyanate, and chloride in dichloromethane in up to 38% current efficiency referred to the corresponding naphthalene derivatives.
    Notizen: Festes Naphthalinradikalkation-hexafluorophosphat reagiert bei -77°C in Dichlormethan mit Tetrabutylammonium-cyanid,- acetat, -thiocyanat und -chlorid mit bis zu 38% Stromausbeute zu den entsprechenden Naphthalinderivaten.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
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  • 81
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3625-3633 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Rearrangements of Vinylogous Acyl Chlorides, XXX: Thermal Rearrangements of Chloro- and Organylthio-substituted (2Z, 4Z)-2,4-Pentadienals and -ones to (2Z, 4Z)-2,4-PentadienethioatesThe pentadienals 2 are prepared by reduction of the corresponding acyl Chlorides 1. The ketone 2d is synthesized from 1b with lithium tert-butyl(phenylthio)cuprate. Elimination of methyl chloride and cyclization occurs on treatment of 1a with AlCl3 giving the 2H-thiopyran-2-one 8. In boiling carbontetrachloride the aldehydes 2 rearrange by 1,5-chlorine shift completely and stereospecifically into the thioates 3. The analogous reaction 2d → 3d is no stereospecific. As expected, compounds 2 and 3 may be converted into the same 4H-pyran-4-ones 6. The rearrangement 2 → 3 is accelerated by RS-groups instead of chlorine in the 5-position and decelerated in the 3-position. The substituent influences and the reaction mechanism are discussed.
    Notizen: Die Pentadienale 2 werden durch Reduktion der entsprechenden Säurechloride 1, dargestellt. Das Keton 2d wird aus 1b mit Lithium-tert-butyl(phenylthio)cuprat synthetisiert. 1a spaltet unter der Wirkung von AlCl3 Methylchlorid ab und cyclisiert zum 2H-Thiopyran-2-on 8. Die Aldehyde 2 lagern sich in siedendem Tetrachlorkohlenstoff unter 1,5-Chlorwanderung vollständig und stereospezifisch in die Thioester 3 um. Die analoge Reaktion 2d → 3d ist nicht stereospezifisch. Erwartungsgemäß liefern die Verbindungen 2 und 3 die gleichen 4H-Pyran-4-one 6. Die Umlagerung 2 → 3 wird durch RS-Gruppen an Stelle von Chloratomen in 5-Stellung beschleunigt und in 3-Stellung verlangsamt. Die Substituenteneinflüsse und der Reaktionsmechanismus werden diskutiert.
    Zusätzliches Material: 1 Tab.
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  • 82
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3741-3750 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Energy Profile of the o-Quinodimethane ⇄ Benzocyclobutene Equilibrium, IIThe kinetics of the decomposition of keton 3 yielding o-quinodimethane (2) (Ea = 25.6 kcal/mol; A = 3.1 × 1013s-1) and its cyclisation to benzocyclobutene (1) (Ea = 26.9 kcal/mol; A = 2.1 × 1012 S-1) is measured by shock tube technic. From the temperature dependence of the equilibrium 1 ⇄ 2 which is studied by the same method, the enthalpy of formation of o-quinodimethane 2 is established to be ΔHfo (g) = 60.8 kcal/mol.
    Notizen: Mit Hilfe der Stoßrohr-Technik werden ausgehend vom Keton 3 Aktivierungsparameter für die Bildung des o-Chinodimethans (2) (Ea = 25.6kcal/mol; A = 3.1 × 10 13 S-1) und dessen Weiterreaktion zum Benzocyclobuten (1) (Ea = 26.9 kcal/mol; A = 2.1 × 1012 S-1) bestimmt. Mit der gleichen Technik wird aus der Temperaturabhängigkeit des Gleichgewichtes 1 ⇄ 2 die Bildungsenthalpie des o-Chinodimethans (2) zu ΔHfo (g) = 60.8 kcal/mol abgeleitet.
    Zusätzliches Material: 2 Ill.
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  • 83
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3751-3771 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Stereoisomerization of Ketene IminesBarriers to racemization in solution of the ketene imines 1a-y and X-ray structures of the ketene imines 1s and z are described. Similar to allenes all ketene imines have dihedral angles of 90° between the C-and N-substituents. The barriers to racemization range from 30 to 63 kJmol-1 and are lowered by electron attracting substituents on C and N. The barriers of m-and p-substituted N-arylketene imines give a linear Hammett correlation with σ- constants. N-Arylketene imines racemize through inversion at nitrogen and simultaneous rotation of the aryl group around the N- aryl bond.
    Notizen: Es werden Racemisierungsbarrieren der Ketenimine 1a-y in Lösung und Röntgenstrukturanalysen der Ketenimine 1s und z beschrieben. Alle Ketenimine haben ein allenartig gewinkeltes Molekülgerüst mit Torsionswinkeln von 90° zwischen den C- und N-Substituenten. Die Racemisierungsbarrieren (ΔG≠) liegen zwischen 30 und 63 KJmol -1 und werden durch elektronenziehende Substituenten am C- und N-Ende erniedrigt. Die Racemisierungsbarrieren m-und p-substituierter N-Arylketenimine korrelieren nach Hammett linear mit σ- - Werten. N-Arylketenimine racemisieren durch inversion am Stickstoff und synchrone Rotation des Arylrestes um die N-Arylbindung.
    Zusätzliches Material: 3 Ill.
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  • 84
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3772-3788 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Alkynes and Cumulenes, XV: On the Photodimerization of Conjugated EnynesOn irradiation in the presence of triplet sensitizers having a triplet energy 〉 250 KJ/mol, vinylacetylene (1a) dimerizes to cis-and trans-1,2-diethynylcyclobutane (cis and trans-2) as well as minor amounts of 4-ethynyl-1-vinylcyclobutene (3). The effect of substituents on the course of the reaction is investigated: whereas alkyl, vinyl, and phenyl substituents, respectively, in the 4-position of 1a do not influence the photoaddition, 2-substituted enynes yield the corresponding cyclobutanes in poor yields only. Finally, 1-substituted vinylacetylenes (besides the substituents mentioned above the influence of ethynyl, chloro, and methoxy groups has been investigated) do not provide photodimers; they are cis-trans-isomerized instead. The mechanism of the photoaddition is discussed.
    Notizen: Vinylacetylen (1a) dimerisiert bie Bestrahlung in Gegenwart von Triplettsensibilisatoren mit einer Triplettenergie 〉 250 KJ/mol zu cis- und trans-1,2-Diethinylcyclobutan (cis- und trans-2) sowie kleineren Mengen an 4-Ethinyl-1-vinylcyclobuten (3). Die Auswirkung von Substituenten auf diese Reaktion wird untersucht: während Alkyl-, Vinyl- und Phenylsubstituenten in 4-Stellung von 1a keinen Einfluß auf die Photoaddition haben, dimerisieren 2-substituierte Enine nur noch in schlechten Ausbeuten zu den entsprechenden Cyclobutanen. Schließlich bilden. 1-Substituierte Vinylacetylene (außer den obigen Substituenten wurde der Einfluß von Ethinyl-, Chlor - und Methoxyresten untersucht) keine Photodimeren, sondern werden lediglich cis-trans-isomerisiert. Der Mechanismus der Photoaddition wird diskutiert.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
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  • 85
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3831-3854 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Migration Aptitudes of Cyclic, Polycyclic, and Branched Alkyl Groups in the Beckmann RearrangementsThe migration aptitudes of polycyclic bridgehead groups, cycloalkyl groups as well as of β-γ-and δ-branched alkyl groups in the Chapman variant of the Beckmann rearrangement were determined. From these data it is concluded that at transition state 2 the migrating group is not resembling a planarised carbenium ion R+, but rather a pentacoordinated carbonium ion structure. Because only small geometrical changes occur in the migrating group vertical stabilisation4) of charge at transition state is believed to have significant influence on the migration aptitudes.
    Notizen: Die Wanderungstendenzen von polycyclischen Brückenkopfresten, Cycloalkylresten sowie β, γ-und -δ-verzweigten Alkylresten bei der Chapman-Variante der Beckmann-Umlagerung wurden bestimmt. Sie zeigen, daß die wandernde Gruppe im Übergangszustand 2 nicht Carbenium-Ionen-Charakter hat, sondern nach weitgehender Beibehaltung ihrer Geometrie eher einer Fünffach koordinierten Carboniumstruktur entspricht, die im Zuge der Umlagerungsreaktion vertikal stabilisiert4 werden kann.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
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  • 86
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3789-3800 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: From Ion Pairs to Radical Complexes: Coordination Compounds of Reduced 2,2′-Bipyridine with Organometallic CationsReduced 2,2′-bipyridine, bipy-·, forms paramagnetic complexes with organometallic cations RnM+ containing metals of the first three groups of the periodic system (n = 0, 1,2). The persistent radicals [RnM)bipy]· have been identified and studied by high resolution electron spin resonance. Their ESR coupling constants can be correlated excellently with results from HMO calculations and exhibit a typical sequence of cations RnM+: K+, Na+, Li+, PhMg+, PhZn+, Me2Ga+, PhBe+, Ph2B+, R2Al+. This series exemplifies the continuous variation from genuine paramagnetic „ion pairs“ mostly covalently bonded radical complexes.
    Notizen: Reduziertes 2,2′-Bipyridin, bipy-·, bildet paramagnetische Komplexe mit metallorganischen Kationen RnM+ aus den ersten drei Gruppen des Periodensystems (n = 0, 1, 2). Die beständigen Radikale [(RnM) bipy]· lassen sich durch hochauflösende Elektronenspinresonanz nachweisen und untersuchen. Ihre ESR-Kopplungskonstanten können vorzüglich mit den Ergebnissen von HMO-Berechnungen korreliert werden, man erhält so eine charakteristische Reihenfolge der Kationen RnM+: K+, Na+, Li+, PhMg+, PhZn+, Me2Ga+, PhBe+, Ph2B+, R2Al+. Diese Serie überdeckt lückenlos den Bereich von echten, paramagnetischen „Ionenpaaren“ bis hin zu überwiegend kovalent aufgebauten Radikalkomplexen.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
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  • 87
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3801-3812 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Boron Imides and Borylnitrenes by Decomposition of DiaminoazidoboranesGas phase thermolysis of azidoboranes (R2N)2BN3 (1a, b) at 450-485°C gives the products 2a (by retro ene-reaction) and 4b (by intramolecular 1,2-alkylohydrogenation), respectively, both from boron imides R2N—B=N—NR2 (9a, b) as intermediates; furthermore, 3a is isolated from the thermolysis of 1a via a borylnitrene (R2N)2B—N by intramolecular 1,1-alkylohydrogenation. The photolysis of 1a, b generates the borylnitrenes 10a, b as intermediates, which are stabilized by an intermolecular reaction to 7a and 8b, respectively; the nitrene 10a can be trapped by ethyloboration with BEt3.
    Notizen: Bei der Gasphasenthermolyse der Azidoborane (R2N)2BN3 (1a, b) bei 450-485°C erhält man Produkte 2a bzw. 4b, die aus den Borimiden R2N — B = N — NR2 (9a, b) durch eine Retro-En-Reaktion bzw. durch eine intramolekulare 1,2-Alkylohydrierung der B=N-Bindung hervorgehen; die Thermolyse von 1a führt daneben zu 3a, einem Folgeprodukt der intramolekularen 1,1-Alkylohydrierung des entsprechenden Borylnitrens (R2N)2B—N. Die Photolyse von 1a, b ergibt die Borylnitrene 10a, b als Zwischenstufen, die intermolekular zu 7a bzw. 8b weiterreagieren; das Nitren 10a läßt sich mit BEt3 durch Ethyloborierung abfangen.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
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  • 88
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3813-3830 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Migration of Alkyl Group in Sextett RearrangementsThe migration aptitude of alkyl groups in the Beckmann-, the Criegee-, and the isonitrile-nitrile rearrangements were investigated. The relative rearrangement rates of substituted benzyl groups are an expression of the charge on the migrating carbon at transition state. From the relative rates of migration of exo- and endo- 2- norbornyl group the geometrical changes at the migrating carbon are estimated. Finally, The different influence of α-branching in the migrating group is discussed for these and some other rearrangements.
    Notizen: Die Wanderungstendenzen von Alkylgruppen bei der Beckmann- Criegee- und Isonitril-Nitril-Umlagerung werden untersucht. Aus den relativen Reaktionsgeschwindigkeiten der substituierten Benzylreste werden Rückschlüsse auf die Ladungsverteilung im Übergangszustand dieser Reaktionen gezogen und aus dem Verhältnis der Wanderungstendenzen des exo und endo- 2- Norbornylrestes auf die Geometrie der wandernden Gruppe im Übergangszustand. Der in verschiedenen Sextettumlagerungen unterschiedliche Einfluß der α-Methylverzweigung in der wandernden Gruppe wird interpretiert.
    Zusätzliches Material: 1 Ill.
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  • 89
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3855-3862 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Preparation and Properties of, and Reaction with, Metal-Containing Heterocycles, XXI: Ring Contraction, Crystal Structures, Properties, and Stability of ManganacycloalkanesWhen the manganacyclohexane derivative (1) is warmed in a sealed tube to 100°C in n-hexane it is changed, probably via a hydridic alkenyl step, to the ring-contracted cyclopentane (2). Crystals of 1 and 2 are orthorhombic and monoclinic, space groups P212121 and P21/c, respectively, with Z = 4. In the Mn — C σ bond of 2 CO and SO2 can be inserted with formation of the cyclic compounds (3) and (4).
    Notizen: Das Manganacyclohexan-Derivat (1) lagert sich beim Erwärmen im Einschlußrohr auf 100°C in n-Hexan, wahrscheinlich über eine hydridische Alkenylstufe, zum ringverengten Cyclopentan (2) um. 1 und 2 kristallisieren orthorhombisch bzw. monoklin in den Raumgruppen P212121 bzw. P21/c mit Z = 4. In die Mn — C-σ-Bindung von 2 läßt sich CO und SO2 einschieben unter Bildung der cyclischen Verbindungen (3) und (4).
    Zusätzliches Material: 1 Ill.
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  • 90
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3863-3877 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Reactions with Monohydrazones of Dicarbonyl Compounds, X: 2-(Dimethylhydrazono)propanal as a Reagent for the Synthesis of 1,4-DiketonesMonohydrazones 7 of unsaturated 1,4-diketones can be prepared by the reaction of methyleneactive ketones 1a-x with 2-(dimethylhydrazono)propanal (5a). From these products unsaturated 8 and saturated 1,4-diketones (9) are obtained in high yield. Reduction of the diketone monodimethylhydrazones 7g, h, i, p, q with sodium borohydride and subsequent hydrolysis leads to the formation of furans 23and/or N-aminopyrroles 24. The synthesis of a Δ1-pyrrolin 30, which was isolated from the poison gland of the South African thief ant Solenopsis punctaticeps is described7.
    Notizen: 2-(Dimethylhydrazono)propanal (5a) läßt sich mit CH-aciden Verbindungen 1a-x, die eine α-ständige Methylengruppe enthalten, zu Hydrazonopropyliden-Derivaten 7a-x umsetzen. Durch Hydrolyse erhält man ungesättigte, 1,4-Diketone 8 und durch deren Reduktion gesättigte 1,4-Diketone 9. Die Monohydrazone 7g, h, i, p, q ergeben nach Borhydrid-Reduktion und Hydrolyse Furane 23 und / oder N-Aminopyrrole 24. Katalytische Hydrierung des Diketon-monodimethyl hydrazons 29 liefert das Δ1-pyrrolin 30, ein Abwehrstoff der aus der Giftdrüse der südafrikanischen Feuerameise Solenopsis punctaticeps isoliert wurde7.
    Materialart: Digitale Medien
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  • 91
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 3070-3078 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Molecular and Crystal Structures of Two Carbodiphosphoranes with P—C—P Bond Angles Near 120°sym-Dimethyltetraphenylcarbodiphosphorane (1) and the cyclic carbodiphosphorane 2 show in the crystalline state the smallest P=C=P bond angles (121.8(3) and 116.7 (7)°, respectively) observed so far among compounds of this type. The lengths of the ylidic P=C bonds (164.8 (4) pm in 1, 164.5 (12) and 165.3 (14) pm in 2) are within the double bond range. In 1 two phenyl rings are parallel with a mutual distance of 328 pm; in the crystal phenyl ring layers are formed. This favourable packing of the phenyl groups should be the reason for the small P—C—P bond angle, whose easy bending is thus demonstrated again.
    Notizen: sym-Dimethyltetraphenylcarbodiphosphoran (1) und das cyclische Carbodiphosphoran 2 haben im Kristall mit 121.8 (3) bzw. 116.7 (7)° die kleinsten P=C=P-Bindungswinkel, die bisher bei Vertretern dieser Verbindungsklasse gefunden wurden. Die ylidischen P=C-Bindungslängen (164.8 (4) pm bei 1, 164.5 (12) bzw. 165.3 (14) pm bei 2) liegen im Doppelbindungsbereich. Bei 1 sind zwei Phenylringe mit einem Abstand von 328 pm parallel zueinander; im Kristall bilden sich Phenylring-Schichten aus. Diese günstige Packung der Phenylgruppen dürfte die Ursache für den kleinen P—C—P-Bindungswinkel sein, dessen leichte Deformierbarkeit damit erneut unter Beweis gestellt wird.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
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  • 92
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 227-231 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Naturally Occuring Terpene Derivatives, 3061) Synthesis of a Furan Sesquiterpene from Eumorphia prostataStarting with 5-methyl-2-cyclohexen-1-one (1) through the intermediate 4 the cyclopentene carbaldyhydes 5 und 6 were synthesized. Wittig reaction led to the epimeric nitriles 7 und 8, which after conversion to the aldehydes 9 and 10 on reaction with β-furyllithium afforded the carbinols 11 and 12. Manganese dioxide oxidation yielded the ketones 13 and 14, their spectral data being in agreement with those of the natural compounds.
    Notizen: Ausgehend von 5-Methyl-2-cyclohexen-1-on (1) werden über das Zwischenprodukt 4 die Cyclopentancarbaldehyde 5 und 6 synthetisiert. Wittig-Reaktion führt zu den epimeren Nitrilen 7 und 8, die nach Überführung in die Aldehyde 9 und 10 durch Reaktion mit β-Furyllithium die Carbinole 11 und 12 liefern. Mangandioxid-Oxidation gibt die Ketone 13 und 14, deren spektroskopischen Daten mit denen der Naturstoffe übereinstimmen.
    Zusätzliches Material: 1 Tab.
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  • 93
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 246-253 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Reaction of Benzofuroxan with KetonesReaction of branched-chain ketones 4 with benzofuroxan (1) in the presence of ammonia yields o-quinoid 2-amino-2,3-dihydro-2,3,3-trialkylquinoxaline 1,4-dioxides 6. The same procedure with KOH catalysis gives the corresponding 2-hydroxy compounds. A synthesis of spiro compounds 16 by using acetylcycloalkanes 15 in this reaction is described. Under different reaction conditions. the reduction products of these compounds were 1,2-dihydro-2,2,3-trialkyl-1-quinoxalinol 4-oxides 19, 22, 23, 1,2,3,4-tetrahydro-2,2,3-trialkylquinoxalines 21, 24, 25 and 1,2-dihydro-2,2,3-trialkylquinoxalines 20, 26.
    Notizen: Durch Umsetzung von verzweigten Ketonen 4 mit Benzofuroxan (1) in Gegenwart von Ammoniak werden o-chinoide 2-Amino-2,3-dihydro-2,3,3,-trialkylchinoxalin-1,4-dioxide (6), in Gegenwart von KOH die analogen 2-Hydroxyverbindungen erhalten. Der Einsatz von Acetylcycloalkanen (15) führt zur Synthese von Spiroverbindungen 16. Als Reduktionsprodukte der genannten Verbindungen werden 1,2-Dihydro-2,2,3-trialkyl-1-chinoxalinol-4-oxide 19, 22, 23, 1,2,3,4-Tetrahydro-2,2,3-trialkylchinoxaline 21, 24, 25 und 1,2-Dihydro-2,2,3-trialkylchinoxaline 20, 26 bei unterschiedlichen Reaktionsbedingungen erhalten.
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  • 94
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 254-266 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Syntheses ESR, and ENDOR Studies of Highly Twisted Phenyl Substituted Radical AnionsThe synthesis of a variety of phenyl substituted and partially deuterated derivatives of anthracene. naphthalene benzo[b]triphenylene, and benzo[k]fluoranthene is given. By performing ESR, ENDOR, and TRIPLE experiments the hyperfine coupling constants, including their signs, of the respective radical anions are determined. Regarding the spin distributions within the phenyl substituents it is shown that the conventional sequence of the hyperfine couplings |HparaH|≥ |HaorthoH| 〉 |HmetaH| is not always valid. These results are interpreted in terms of a significant π-σ-mixing, i. e. a phenyl hyperconjugation effect.
    Notizen: Die Synthese phenylsubstituierter, zum Teil deuterierter Abkömmlinge des Anthracens, des Naphthalins, des Benzo[b]triphenylens und des Benzo[k]fluoranthens wird beschrieben. Mit Hilfe von ESR-, ENDOR- und TRIPLE-Experimenten werden die Hyperfeinkopplungskonstanten der korrespondierenden Radikalanionen einschließlich ihrer relativen Vorzeichen bestimmt und den jeweiligen Molekülpositionen zugeordnet. Für einige der untersuchten Systeme wird gezeigt, daß in der Spindichteverteilung der Phenylsubstituenten verdrillungsbedingte Abweichungen von der konventionellen Sequenz |HparaH|≥ |HaorthoH| 〉 |HmetaH| auftreten, die mit einer Phenylhyperkonjugation gedeutet werden können.
    Zusätzliches Material: 6 Ill.
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  • 95
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 298-305 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Boron Imides from the Thermal Decomposition of Dialkyl[sily(silyloxy)amino]boranesDialkyl[trimethylsilyl)(trimethylsilyloxy)amino]boranes R2B—N(OSiMe3SiMe3 (1a-c), prepared from (Me3Si)2N—OSiMe3 and R2BCl, can be thermolyzed in the liquid phase at 70°C to form (Me3SI)2O and a mixture of R2B—NR—Br—N(OSiMe3)SiMe3 (2a-c) and (RBNR)3 (3a-c). In the presence of an excess of BR′3, 1b, c can be transformed into (Me3Si)2O and diborylamines RR′B—NR—BR′2 (4b), c, (Me3Si)2O and a mixture of (RBNR)3 and polymer material are formed from the gas-phase thermolysis of 1b, c at 270°C The polymer (EtBNEt)n depolymerizes to the borazine 3b above 150°C. An intermediate from the gas-phase thermolysis of 1b can be trapped by liquid 1c, yielding 2c, A. conclusive explanation of all these observation is possible by the assumption that boron imides RB—NR(5a-c) occur as intermediates.
    Notizen: Die aus (Me3Si)2N-OSiMe3 und R2BCl zugänglichen Dialkyl[trimethylsilyl)(trimethylsilyloxy)amino]borane R2B—N(OSiMe3)SiMe3 (1a-c zerfallen in flüssiger Phase bei 70°C unter Abspaltung von (Me3Si)2O in ein Gemisch aus R2B—NR—BR—N(OSiMe3)SiMe3 (2a-c) und (RBNR)3 (3a-c). Im Überschuß von BR′3 erhält man aus 1b, c neben (Me3Si)2O die Diborylamine RR′B—NR—BR′2 (4b-c). In der Gasphase entstehen bei 270°C aus 1b, c (Me3Si)2O und ein Gemisch aus (RBNR)3 und Polymeren. Das Polymere (EtBNEt)n depolymerisiert oberhalb 150°C zu 3b. Flüssiges 1c regiert mit einer aus 1b durch Gasphasenthermolyse gebildeten Zwischenstufe zum Abfangprodukt 2c′. Einer geschlossenen Deutung aller Befunde liegt die Annahme von Borimiden RB—NR (5a-c) als Zwischenstufen zugrunde.
    Materialart: Digitale Medien
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  • 96
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 322-332 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Building Units for Oligosaccharides, XXI1) Syntheses of Gentamicin X2 and Gentamicins Modified At C-4′ and C-3′The garamine derivative 18 can be coupled with the β-chloride 15 of 2-azido-2-deoxy-D-glucose to 20 from which, by deblocking procedure, gentamicin X2 (23) is available. In the same manner the 4′-amino- and 4′-chloro compound 24 and 25, resp., can be obtained. Coupling of 26 with 19 gives the product 27 from which the derivative 28 of gentamicin, modified at C-3′, is prepared.
    Notizen: Das Garamin-Derivat 18 läßt sich mit dem β-Chlorid 15 der 2-Azido-2-desoxy-D-glucose zu 20 kuppeln, aus dem durch Entblockierung Gentamicin X2 (23) erhältlich ist. Auf gleichem Wege ist die 4′-Amino- und 4′-Chlorverbindung 24 bzw. 25 zu gewinnen. Ein am C-3′ modifiziertes Derivat 28 des Gentamicins ist nach Kupplung von 26 mit 19 aus dem Produkt 27 zugänglich.
    Materialart: Digitale Medien
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  • 97
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 306-321 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Building Units for Oligosaccharides, XX1) Synthesis of the Oligosaccharide Determinants of Blood Group Substances of Type 2 of the ABH System. Discussion of α-Glycoside SynthesisThe antigenic determinants of type 2 of blood-group substances A and B (23 and 24) (see German Summary) as well as blood-group substance H (17) were synthesized by selective glycosidation reactions combined with a series of blocking and deblocking steps. The possibilities and optimization of the α-glycoside synthesis are discussed. In hemagglutination inhibition tests the synthetic haptens A and B of type 2 and type 1 show a similar selective inhibitory effect. In case of hapten H, however, great differences can be observed. Here the type 2 exhibited a strong inhibition activity, whereas type 1 only showed an extremely low activity. The leads to the conclusion that in the determinants of the ABH-system on the surface of erythrocytes the chemical structure of type 2 is predominating.
    Notizen: Durch eine Folge von selektiven Glycosid-Synthesen, kombiniert mit einer Serie von Blockierungs-und Entblockierungsschritten wurden die Determinanten der Type 2 der Blutgruppensubstanzen A und B und H α-L-Fuc-(1-2)-β-D-Gal-(1-4)-D-GlcNac (17) synthetisiert. Die Möglichkeiten und die Optimierung der α-Glycosid-Synthese werden diskutiert. Im Hämagglutinations-Inhibitionstest zeigen die synthetischen Haptene A und B der Type 2 und Type 1 eine ähnliche selektive Hemmwirkung. Starke Unterschiede sind aber beim Hapten H zu beobachten. Hier hemmt die Type 2 sehr stark, die Type 1 dagegen äußerst schwach. Hieraus ist zu schließen, daß in den Oberflächendeterminanten des ABH-Systems der Erythrozyten die chemische Struktur der Type 2 dominiert.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
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  • 98
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 292-297 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Synthesis of Optically Active Trogoderma pheromones by Kolbe-Electrolysis1)The (R)-(-)-enantiomers of (Z)- (1) and (E)-14-methyl-8-hexadecen-1-ol (2) have been synthesized by coelectrolysis of (R)-(-)-4-methylhexanoic acid (7) with 12-(tetrahydro-2-pyranyloxy)-4-dodecynoic acid (8) and its subsequent hydrogenation. The acid 7 was prepared in high optical purity from (S)-(-)-citronellol (3) by conversion of the hydroxyl group to a methyl substituent and subsequent clevage of (R)-(-)2,6-dimethyl-2-octene (4) with ozone. By alkylation of 4-pentynoic acid (5) with 1-bromo-7-(tetrahydro-2-pyranyloxy)heptane (6) the alkynoic acid 8 was synthesized.
    Notizen: Die (R)-(-) Enantiomeren des (Z)- (1) und (E)-14-Methyl-8-hexadecen-1-ols (2) wurden durch Coelektrolyse von (R)-(-)-4-Methylhexansäure (7) mit 12-(Tetrahydro-2-pyranyloxy)-4-dodecinsäure (8) und nachfolgende Hydrierung synthetisiert. Die Säure 7 wird in hoher optischer Reinheit ausgehend von (S)-(-)-Citronellol (3) durch Reduktion der Alkoholfunktion zur Methylgruppe und anschließende ozonolytische Spaltung des (R)-(-)-2,6-Dimethyl-2-octens (4) gewonnen. Durch Alkylierung von 4-Pentinsäure (5) mit 1-Brom 7-(tetrahydro-2-pyranyloxy) heptan (6) läßt sich die Alkinsäure 8 darstellen.
    Materialart: Digitale Medien
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  • 99
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 333-345 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Building Units for Oligosaccharides, XXII1) Synthesis of the Trisaccharide Sequence α-D-GlcNAc(1→4)-β-D-Gal-(1→4)-D-GlcNac of Blood Group Active SubstancesA directly stereoselective α-glycoside synthesis to oligosaccharides succeeds in the presence of AgClO4/Ag2CO3 in methylene chloride with the α-bromide 1 of 2-azido-2-deoxy-D-glucose. By reaction with 1 the disaccharides 3, 7a, 7b, 18 and the trisaccharide 24 are obtainable. Deblocking of 7 yields free α-D-GlcNAc(1→4)-D-Gal (11) and that of 24 free α-G-GlcNAc-(1→4)-β-D-Gal-(1→4)-D-GlcNAc (27).
    Notizen: Eine direkte stereoselektive α-Glycosid-synthese zu Oligosacchariden gelingt mit dem α-Bromid 1 der 2-Azido-2-desoxy-D-glucose bei Gegenwart von AgCIO4/Ag2CO3 in Methylenchlorid. Durch Umsetzung mit 1 lassen sich die Disaccharide 3, 7a, 7b, 18 und das Trisaccharid 24 gewinnen. Die Entblockierung von 7 liefert freies α-D-GlcNac-(1→4)D-Gal (11), die von 24 freies α-D-GlcNAc-(1→4)β-Gal-(1→4)-D-GlcNAc (27).
    Materialart: Digitale Medien
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  • 100
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 114 (1981), S. 495-504 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Beschreibung / Inhaltsverzeichnis: Synthesis and Properties of 1,3,2-Diazaboroline Complexes1,3-Ditert-butyl-2-methyl-Δ4-1,3,2-diazaboroline (1a) and 2-methyl-1,3-bis(trimethylsilyl)-Δ4-1,3,2-diazaboroline (1b) react with (CH3CN)3Cr(CO)3 to form the diazaboroline complexes(ring)-Cr(CO)3 (2a,b). The Synthesis of 2a also succeeds with Cr(CO)6 and 1a by UV irradiation or thermically. The diazaborolines 1a and 1b serve as 6π-electron donors. In contrast, 2,4,5-trimethyl-1,3-diphenyl-Δ4-1,3,2-diazaboroline (1c) is coordinated to the Cr(CO)3 group via one of the phenyl rings (2c). P(C6H5)3 substitutes the diazaboroline in 2a to form (CO)4CrP(C6H5)3]2, whereas NO+ displaces one CO group to give dicarbonyl[η5-(1,3-di-tert-butyl-2-methyl-1, 3,2-diazaboroline)]nitrosylchromium-hexafluorophosphate (3). Mesitylene substitutes the diazaboroline ring, while hexamethylborazine starts no reaction. As a result of IR, 1H-, 11B-, 13C-NMR as well as mass spectroscopic investigations, proposals for the molecular are made.
    Notizen: 1,3-Di-tert-butyl-2-methyl-Δ4-1,3,2-diazaborolin (1a) und 2-Methyl-1,3-bis(trimethylsilyl)-Δ4-1,3,2-diazaborolin (1b) reagieren mit (CH3CN)6Cr(CO)3 zu den Diazaborolinkomplexen (Ring)-Cr(CO)3 (2a,b). Die Synthese von 2a gelingt auch aus Cr(CO)3 und 1a durch UV-Bestrahlung oder thermisch. Die Diazaboroline 1a und 1b dienen als 6π-Elektronendonatoren. Im Gegensatz dazu wird 2,4, 5-Trimethyl-1,3-diphenyl-Δ4-1,3,2-diazaborolin (1c) über einen der Phenylringe an die Cr(CO)3-Gruppe koordiniert (2c). P(C6H5)3 substituiert in 2a das Diazaborolin und bildet (CO)4Cr[P(C6H5)3]2, während NO+ eine CO-Gruppe verdrängt und Dicarbonyl[η5-(1,3-di-tert-butyl-2-methyl-1,3,2-diazaborolin)nitrosylchrom-hexafluorophosphat (3) ergibt. Mesitylen substituiert den Diazaborolinring, wogegen Hexamethylborazin keine Reaktion auslöst. Aufgrund von IR-, 1H-, 11B-, 13C-NMR-sowie massenspektroskopischen Untersuchungen werden Vorschläge für die Molekülstrukturen gemacht.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
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