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  • 1995-1999  (12,118)
  • 1995  (12,118)
  • Chemistry  (11,922)
  • Magnetic resonance imaging  (196)
  • Nuclear reactions
  • 101
    ISSN: 1432-1920
    Keywords: Idiopathic intracranial hypertension ; Visual loss ; Magnetic resonance imaging ; Blood-retinal barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case is reported of a patient with idiopathic intracranial hypertension examined with magnetic resonance imaging. Marked enhancement of the optic nerve heads was found, which might be related to blood-retinal barrier breakdown related to a sudden rise in intracranial cerebrospinal fluid pressure.
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  • 102
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 356-361 
    ISSN: 1432-1920
    Keywords: Key words Moyamoya disease ; Magnetic resonance imaging ; Cerebral angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our purpose was to evaluate the diagnostic accuracy of MRI in moyamoya disease. We studied 30 patients with this disease, comparing MRI and angiographic findings. The diagnostic value of MRI was evaluated for occlusive lesions, collateral vessels, and parenchymal lesions. In all patients bilateral occlusion or stenosis of the supraclinoid internal carotid artery and proximal anterior and middle cerebral arteries was clearly shown by MRI, and staging of the extent of occlusion agreed with angiographic staging in 44 (73 %) of 60 arteries. MRI, particularly coronal images, clearly showed basal cerebral moyamoya vessels in 54 hemispheres, and 45 of a total of 71 large leptomeningeal and transdural collateral vessels were identified. MRI also showed parenchymal lesions in 48 (80 %) hemispheres, and the extent of occlusion in the anterior and posterior circulations respectively correlated with white matter and cortical and/or subcortical infarcts.
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  • 103
    ISSN: 1432-1920
    Keywords: Key words Myelopathy ; Demyelinating disease ; Multiple sclerosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of cerebral and spinal cord MRI was investigated in 65 patients with myelopathy suspected of having demyelinating disease. Cerebral MRI demonstrated lesions compatible with demyelination in 80 % and spinal cord MRI in 68.6 %. In 28.5 % of our patients brain lesions were present with normal spinal cord images, but in 17 % spinal cord lesions were depicted with a normal brain MRI. The combination of the two examinations demonstrated lesions in 97 % of the patients. The frequency of coexistent cerebral lesions in patients with spinal cord lesions was over 85 % in patients with chronic disease but only 28.5 % in patients with acute myelitis.
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  • 104
    ISSN: 1432-1920
    Keywords: Key words Meninges ; Contrast enhancement ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe thickening and contrast enhancement of the intracranial pachymeninges, revealed by MRI in a patient with presumed low-pressure headache following dural puncture and a blood patch. The clinical and radiological abnormalities resolved within 2 weeks.
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  • 105
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 453-455 
    ISSN: 1432-1920
    Keywords: Key words Cerebrospinal fluid ; Rhinorrhoea ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied two patients with spontaneous cerebrospinal fluid (CSF) rhinorrhoea with MRI and other imaging modalities. T2-weighted images proved most useful for the detection and localisation of the CSF leakage. MRI appeared to provide an accurate and noninvasive method for preoperative investigation of spontaneous CSF rhinorrhoea.
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  • 106
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 462-464 
    ISSN: 1432-1920
    Keywords: Key words Epidural abscess ; Magnetic resonance imaging ; Gadolinium-DTPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 10-year-old boy presented with a 7-day history of back pain and pyrexia. MRI showed an epidural abscess arising from septic arthritis in a lumbar facet joint. Whilst septic arthritis in a large joint is relatively common in children, epidural abscess is rare. This case illustrates how infection in a synovial joint may extend into the extradural space and might be the route of infection in more cases than has previously been recognised.
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  • 107
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 479-480 
    ISSN: 1432-1920
    Keywords: Key words Meningioma ; Internal auditory meatus ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe an entirely intracanalicular meningioma in a 49-year-old woman, mimicking an acoustic neuroma on CT cisternography and MRI.
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  • 108
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 559-560 
    ISSN: 1432-1920
    Keywords: Key words Cervical spine ; Spondylolysis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of cervical spondylolysis, unusual in that it was associated with spinal cord compression.
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  • 109
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Brain neoplasms ; Tissue characterisation ; Magnetisation transfer contrast ; Gadolinium-DTPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed MRI on 85 patients with intracranial tumours to evaluate quantitative analysis in tumour characterisation. Signal intensities were measured on standard T2-and T1-weighted images, Gd-enhanced T1-weighted images and magnetisation transfer (MT) images. Statistically significant differences between tumour types were observed, but overlapping reduces their value. T2-weighted imaging was superior to T1-weighted imaging for tumour characterisation. Quantification of Gd enhancement was useful in the diagnosis of pituitary adenomas and haemangioblastomas, but of minor importance in other tumours, because of large nonspecific variation. The contribution of MT contrast to tumour characterisation resembled that of T2 contrast. However, MT imaging was superior to other sequences in the classification of intra-axial tumours. Low-grade astrocytomas, haemangioblastomas and craniopharyngiomas could be differentiated from other tumours on the basis of MT contrast. Reliable discrimination between meningiomas, high-grade astrocytomas and metastases was not possible by any of the methods.
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  • 110
    ISSN: 1432-1920
    Keywords: Sinus thrombosis ; Reperfusion ; Cerebral infarction ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 50-year-old woman with idiopathic deep cerebral sinus and vein thrombosis (DCVT) had cerebellar disturbance prior to impaired consciousness. CT and MRI revealed haemorrhagic infarction in the cerebellum and signal changes suggesting infarction in the thalamus and basal ganglia bilaterally. The straight sinus and internal cerebral vein (ICV) were dense on CT. On angiography, the vein of Galen (VG) and straight sinus were not seen. Following clinical recovery, CT and MRI became normal, and angiography showed recanalization of the VG and ICV. The relationship between cerebellar infarction and DCVT, and signal changes on CT and MRI are discussed.
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  • 111
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 649-652 
    ISSN: 1432-1920
    Keywords: Carmofur ; 5-Fluorouracil ; Leukoencephalopathy ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Carmofur, a derivative of 5-fluorouracil, has recently been noted to have an infrequent but serious association with leukoencephalopathy. To our knowledge, there has been no report of early MRI findings in this leukoencephalopathy. We describe a case in which diffuse high signal intensity of the entire cerebral white matter, including the corpus callosum, was seen on T2-weighted magnetic resonance images. Although similar findings can be seen in many other diseases, carmofur-induced leukoencephalopathy should be suspected in a patient treated with carmofur. It is important to know the clinical and MRI characteristics of this condition, for early diagnosis and better prognosis.
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  • 112
    ISSN: 1432-1920
    Keywords: Key words Pineal region tumours ; Magnetic resonance imaging ; Germ cell tumours ; Pineal cell tumours ; Meningiomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A variety of tumours may arise in the pineal region; accurate diagnosis is important in the selection of treatment and prognosis. A retrospective analysis of the MRI studies of 25 patients with pathologically proven pineal region tumours was performed, focused on the relationship between the tumour and neighbouring structures. Compression of the tectal plate was classified as expansive or invasive, and compression of the corpus callosum as inferior, anterior or posterior. In 10 of the 14 patients (71 %) with germ cell tumours tectal compression was of the invasive type; 8 patients (57 %) had multiple tumours and in 13 (93 %) the tumour margins were irregular. Teratomas were readily diagnosed because of characteristic heterogeneous signal intensity. Pineal cell tumours were differentiated from germ cell tumours by their rounded shape, solid nature, sharp margins, and expansive type of tectal compression. Meningiomas were characterised by their falcotentorial attachments, posterior callosal compression, and a low-intensity rim on T2-weighted images. Gd-DTPA injection enabled clear demonstration of the site and extent of tumour spread and was useful in differentiating cystic and solid components. The appearances described, while not pathognomonic, are helpful in the differential diagnosis of pineal region tumours, and valuable in planning appropriate treatment.
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  • 113
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric cardiology 16 (1995), S. 291-293 
    ISSN: 1432-1971
    Keywords: Innominate vein ; Brachiocephalic artery anomaly ; Angiocardiography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An unique case of left innominate vein compression by a leftward origin of a brachiocephalic artery in conjunction with an aberrant right subclavian artery anomaly occurred in a young patient. Aortography and magnetic resonance imaging were invaluable in arriving at a diagnosis.
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  • 114
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric nephrology 9 (1995), S. 247-249 
    ISSN: 1432-198X
    Keywords: Nephrotic syndrome ; Cerebral venous thrombosis ; Diagnosis ; Treatment ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 115
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric cardiology 16 (1995), S. 48-50 
    ISSN: 1432-1971
    Keywords: Cardiac tumor ; Hemangiopericytoma ; Infant ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A male infant with benign hemangiopericytoma of the right atrium is reported. His chief complaint was acute respiratory distress secondary to bloody pericardial effusion. Although the entire mass could not be removed surgically, there was no recurrence of cardiac tamponade or growth of the residual mass during a follow-up period of 3 years. This patient is, to our knowledge, the youngest one with primary cardiac hemangiopericytoma so far reported.
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  • 116
    ISSN: 1432-1920
    Keywords: Dermoid cyst ; Spinal tumor ; Magnetic resonance imaging ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 33-year-old man presented with a 3-month history of gradually progressive leg weakness. Spinal MRI and myelography with CT demonstrated an extensive intradural abnormality suggesting a diffuse inflammatory or neoplastic process. Only after cranial CT and MRI demonstrated lipid droplets was the diagnosis of a ruptured spinal dermoid cyst suggested. Subsequent laminectomy revealed a ruptured intradural dermoid cyst in the lumbar spine, with chemical arachnoiditis.
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  • 117
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Gadolinium enhancement ; Multiple sclerosis ; Immunosuppression ; Mitoxantrone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serial gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) was used to monitor the effect of mitoxantrone in ten patients with rapidly deteriorating multiple sclerosis (MS). MRI was performed as a baseline and thereafter at 1,3,6,9,12 and 24 months. The total number of Gd-enhancing lesions diminished from 169 at baseline to 10 after 1 year and to 5 after 2 years. This reduction and the percentage of follow-up MRI studies showing no Gd enhancement were more pronounced than in other MRI studies of the natural course of MS. Measured with quantitative neurological scales, only one patient showed deterioration after 2 years; nevertheless, the changes in MRI were much more marked than those observed clinically. Serial Gd-MRI therefore, seems necessary for documenting efficacy in future therapeutic trails.
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  • 118
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 127-128 
    ISSN: 1432-1920
    Keywords: Central nervous system ; Siderosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a rare entity, superficial siderosis of the central nervous system, due to multiple small episodes of subarachnoid haemorrhage from any source. Non-specific neurological findings are associated with deposition of ironcontaining pigments in the leptomeninges and superficial layers of the cortex. T2-weighted magnetic resonance imaging demonstrates characteristic low signal in the meninges.
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  • 119
    ISSN: 1432-1920
    Keywords: Key words Corpus callosum ; Hydrocephalus ; Dementia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate morphological changes in the corpus callosum in hydrocephalus and to correlate them with clinical findings we studied sagittal T2*-weighted cine MR images of 163 patients with hydrocephalus. The height, length and cross-sectional area of the corpus callosum were measured and related to the type of cerebrospinal fluid flow anomaly and to clinical features, especially dementia. With expansion of the lateral ventricles the corpus callosum showed mainly elevation of its body and, to a lesser degree, increase in length. Upward bowing was more pronounced in noncommunicating than in communicating hydrocephalus. Dorsal impingement on the corpus callosum by the free edge of the falx correlated with the height of the corpus callosum. Cross-sectional area did not correlate with either height, length or impingement; it was, however, the strongest anatomical discriminator between demented and nondemented patients. The area of the corpus callosum was significantly smaller in patients with white matter disease. Our findings suggest that, due to its plasticity, the corpus callosum can to some degree resist distortion in hydrocephalus. Dementia, although statistically related to atrophy of the corpus callosum, is possibly more directly related to white matter disease.
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  • 120
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 303-307 
    ISSN: 1432-1920
    Keywords: Spine neoplasm ; Lymphoma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed the MRI features in eight patients with spinal epidural lymphoma (clinically primary in 4 patients); one patient had multiple lesions. The cervical spine was involved in one patient, the thoracolumbar spine in 5 and the sacrum in two. Mean longitudinal extension of the epidural lesion was 2.6 vertebral segments. The tumours were homogeneously isointense with the spinal cord on T1-weighted images and isointense or hyperintense on proton-density and T2-weighted images. The spinal cord was compressed in four patients but showed signal changes in only one. In five patients the lesions communicated through the intervertebral formaina with paravertebral soft tissue masses. In all but one of the patients diffuse signal changes in the vertebral body marrow consistent with osteolytic or osteobalstic changes were identified adjacent to or at distance from the epidural lesion. Vertebral collapse was observed in two patients.
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  • 121
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 326-327 
    ISSN: 1432-1920
    Keywords: Osteoblastoma ; Skull ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated a 27-year-old woman with a retroauricular tumour. MRI revealed a signal void on T1- and T2-weighted images, and irregular enhancement with gadolinium-DTPA. The underlying dura mater also enhanced. The tumour was resected completely, and histological examination showed a benign osteoblastoma.
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  • 122
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 465-467 
    ISSN: 1432-1920
    Keywords: Key words Leiomyosarcoma ; bone ; Spine ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a 39-year-old man with tumour of the eighth thoracic vertebra, causing compression of the spinal cord. The tumour proved to be a primary leiomyosarcoma (LMS) of bone, an uncommon neoplasm; to our knowledge this is the first report of primary LMS in the spine. The lesion was documented by plain radiography, myelography, CT, MRI and digital subtraction angiography. These investigations did help to focus on the differential diagnosis and demonstrated the extent of the bony lesion, the findings were nonspecific, and the correct diagnosis was established by pathological examination.
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  • 123
    ISSN: 1432-1920
    Keywords: Key words Internal auditory canal ; Acoustic schwannoma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prospective baseline MRI was obtained on 31 patients who had “total” removal of acoustic schwannoma 6 months to 9 years previously. Follow-up MRI was performed after 1–2 years on patients with questionable abnormalities. We found four patterns (1) internal auditory canals (IAC) with nonenhancing soft-tissue strands, possibly scars or distorted residual nerves (8); (2) IAC with marginal enhancement-reactive dura mater (16); (3) IAC with contrast-enhancing globular tissues suggesting residual or recurrent tumour (5); (4) high-signal intensity in the IAC before contrast medium administration, probably related to graft with fat/fascia/muscle (2). Prospective 1- to 2-year follow-up studies were available in 8, 5, and 1 patients in groups 2, 3, and 4 respectively. In group 2, dural enhancement remained unchanged in 5 patients and decreased in 3. In group 3 follow-up showed 1 tumor recurrence (surgically confirmed) and 4 stable abnormalities. In group 4, follow-up in 1 of the 2 patients was stable. In groups 1 and 2, the MRI features correlate well with complete tumor removal. Whether follow-up in these groups is indicated needs to be determined. In group 3 residual or recurrent tumor cannot be excluded. In group 4, grafts may prevent adequate visualization of the IAC.
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  • 124
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 331-333 
    ISSN: 1432-1920
    Keywords: Key words Mineralizing microangiopathy ; Chemotherapy ; Radiotherapy ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mineralizing microangiopathy, a distinctive histopathologic process involving the microvasculature of the central nervous system (CNS), is usually seen following combined radiation and chemotherapy for the treatment of CNS neoplasms in childhood. CT typically demonstrates calcification within the basal ganglia and subcortical white matter. The areas of calcification may give paradoxically increased signal on T1-weighted MRI due to a surface-relaxation mechanism, and decreased signal on T2-weighted images.
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  • 125
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 443-444 
    ISSN: 1432-1920
    Keywords: Chronic thinner intoxication ; Magnetic resonance imaging ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied a 19-year-old man with thinner and toluene poisoning for 5 years by CT and MRI. Symmetrical lesions were seen in the basal ganglia and cingulate gyri.
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  • 126
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 453-455 
    ISSN: 1432-1920
    Keywords: Cerebrospinal fluid ; Rhinorrhoea ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied two patients with spontaneous cerebrospinal fluid (CSF) rhinorrhoea with MRI and other imaging modalities. T2-weighted images proved most useful for the detection and localisation of the CSF leakage. MRI appeared to provide an accurate and noninvasive method for preoperative investigation of spontaneous CSF rhinorrhoea.
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  • 127
    ISSN: 1432-1920
    Keywords: Hereditary motor and sensory neuropathy type III ; Sural nerve ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated two patients with herediatary motor and sensory neuropathy type III, one with Déjérine-Sottas disease and the other with congenital hypomyelination neuropathy based on nerve pathology and MRI of the sciatic nerve. On biopsy of the sural nerve of the patient with Déjérine-Sottas disease, myelin debris, indicating demyelination, was observed in an onion-bulb pattern surrounding myelinated fibres. In the patient with congenital hypomyelination neuropathy, onion bulbs were formed of two parallel layers of basement membrane. There was no evidence of myelin breakdown. On axial T2-weighted MRI, a severely hypertropied sciatic nerve containing multiple rounded lesions, suggesting inflammation or demyelination, was observed in the patient with Déjérine-Sottas disease. In contrast, the sciatic nerve of the patient with congenital hypomyelination neuropathy showed slight hypertrophy without demyelination. MRI of the sciatic nerve may represent a useful tool for characterisation of demyelinating disease and its prognosis.
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  • 128
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 37 (1995), S. 438-439 
    ISSN: 1432-1920
    Keywords: Key words Progressive dysphasia ; Status epilepticus ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Status epilepticus is usually a straightforward diagnosis when a patient has two or more seizures without regaining consciousness. However, when status is nonconvulsive and, in particular, has a temporal lobe flavour the clinical presentation may be misleading. Presentation with automatic or psychic behaviour is well recorded. We report a patient with nonconvulsive status who presented with progressive dysphasia with widespread CT and MRI changes. The dysphasia and imaging changes led to a diagnosis of a probable neoplastic brain process but reversed with anticonvulsant treatment.
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  • 129
    ISSN: 1432-1920
    Keywords: Creutzfeldt-Jacob disease ; Magnetic resonance imaging ; Prion protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a 66-year-old woman with histologically diagnosed Creutzfeldt-Jacob disease (CJD), followed with MRI from an early clinical stage. MRI demonstrated expansion of the high cortical signal on T2-weighted images, which differs from previous MRI reports of CJD. This patient followed an atypical clinical course: 16 months had passed before she developed akinetic mutism, and periodic sharp waves had not been detected on EEG after 2 years in spite of her akinetic mutism. Brain biopsy showed primary spongiform changes in the grey matter, and a point mutation of the prion protein gene at codon 180 was discovered using polymerase chain reaction direct sequencing and Tth 111 I cutting. This is the first case with the point mutation of the codon 180 variant with an atypical clinical course and characteristic MRI findings.
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  • 130
    ISSN: 1432-1920
    Keywords: Myelopathy ; Demyelinating disease ; Multiple sclerosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of cerebral and spinal cord MRI was investigated in 65 patients with myelopathy suspected of having demyelinating disease. Cerebral MRI demonstrated lesions compatible with demyelination in 80% and spinal cord MRI in 68.6%. In 28.5% of our patients brain lesions were present with normal spinal cord images, but in 17% spinal cord lesions were depicted with a normal brain MRI. The combination of the two examinations demonstrated lesions in 97% of the patients. The frequency of coexistent cerebral lesions in patients with spinal cord lesions was over 85% in patients with chronic disease but only 28.5% in patients with acute myelitis.
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  • 131
    ISSN: 1432-1920
    Keywords: Key words Idiopathic orbital inflammatory syndrome ; Orbital pseudotumour ; Fat saturation ; Gadolinium ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Idiopathic orbital inflammatory syndrome encompasses a group of inflammatory conditions for which no systemic or local cause can be found, and is commonly referred to as orbital pseudotumour. On conventional MRI sequences subtle areas of inflammation or enhancing tissue can easily be masked by the high signal intensity of orbital fat and involvement of the fat itself may not be appreciated. We describe the MRI features of three patients with idiopathic orbital inflammation using frequency-selective fat saturation and Gd-DTPA.
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  • 132
    ISSN: 1432-1920
    Keywords: Key words Hereditary motor and sensory neuropathy type III ; Sural nerve ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated two patients with hereditary motor and sensory neuropathy type III, one with Déjérine-Sottas disease and the other with congenital hypomyelination neuropathy based on nerve pathology and MRI of the sciatic nerve. On biopsy of the sural nerve of the patient with Déjérine-Sottas disease, myelin debris, indicating demyelination, was observed in an onion-bulb pattern surrounding myelinated fibres. In the patient with congenital hypomyelination neuropathy, onion bulbs were formed of two parallel layers of basement membrane. There was no evidence of myelin breakdown. On axial T2-weighted MRI, a severely hypertropied sciatic nerve containing multiple rounded lesions, suggesting inflammation or demyelination, was observed in the patient with Déjérine-Sottas disease. In contrast, the sciatic nerve of the patient with congenital hypomyelination neuropathy showed slight hypertrophy without demyelination. MRI of the sciatic nerve may represent a useful tool for characterisation of demyelinating disease and its prognosis.
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  • 133
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Spatial autocorrelation ; Cerebral HIV disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was carried out using MRI (proton density-and T2-weighted) on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25 with CDC IV HIV disease. The studies from this last group had previously been allocated by a radiologist to the following categories: 8 with focal mass lesions and normal-appearing white matter; 9 with diffuse encephalopathy (high signal on T2-weighted images, affecting most or all of the white matter) and 8 with patchy encephalopathy (high signal affecting only one or two areas within the white matter). Moran'sI, a statistic of spatial autocorrelation, was calculated for the grey-scale values of a sampled pixel array from a central white matter region of each of the images. All values of Moran'sI calculated in this study showed a large positive excess over the expected value under randomisation, indicating highly significant positive autocorrelation in the spatial arrangement of the grey-scale values. On T2-weighted images a statistically significant increase in the mean value of Moran'sI, compared with controls, was found in the diffuse encephalopathy group, indicating that quantifiable changes in the spatial autocorrelation of pixel data can be related to recognised qualitative changes in the appearance of white matter in subjects with HIV disease. A lesser, but significant, rise in the mean value of Moran'sI was also found in the focal mass lesion group, suggesting that changes in spatial autocorrelation may indicate pathological change in advance of qualitative MRI changes.
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  • 134
    ISSN: 1432-0533
    Keywords: Key words Pes cavus ; Magnetic resonance imaging ; Pathology ; Morphometry ; Peroneus longus hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enlargement of the peroneus longus muscle is a common occurrence in patients with forefoot pes cavus, and may contribute to the cavus deformity. The present study compares the morphology of up to five lower leg muscles from 17 patients with forefoot pes cavus with those of normal muscles. Eight cases had an identifiable neurogenic cause for the cavus. In four cases of hereditary motor-sensory neuropathy, the tibialis anterior showed more severe damage than the peroneus longus. In two cases of cerebral palsy, fibre atrophy and increased oxidative enzyme activity were observed. In nine clinically idiopathic cases, the histological appearances ranged from normal to generalised fibre atrophy or hypertrophy in individual muscles. There was a trend for the mean fibre area to be greater in peroneus longus than in tibialis anterior in six of the idiopathic group of patients. The muscle cross-sectional area on magnetic resonance imaging was correlated closely with the mean fibre area measured on tissue sections. In idiopathic forefoot pes cavus, fibre hypertrophy in peroneus longus (relative to tibialis anterior) may contribute to the cavus deformity. Muscle fibre hyperplasia may contribute to the peroneal muscle enlargement in Friedreich's ataxia. In none of the cases was peroneus longus enlargement due to fat or fibrous tissue replacement.
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  • 135
    ISSN: 1432-0533
    Keywords: Pes cavus ; Magnetic resonance imaging ; Pathology ; Morphometry ; Peroneus longus hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Enlargement of the peroneus longus muscle is a common occurrence in patients with forefoot pes cavus, and may contribute to the cavus deformity. The present study compares the morphology of up to five lower leg muscles from 17 patients with forefoot pes cavus with those of normal muscles. Eight cases had an identifiable neurogenic cause for the cavus. In four cases of hereditary motor-sensory neuropathy, the tibialis anterior showed more severe damage than the peroneus longus. In two cases of cerebral palsy, fibre atrophy and increased oxidative enzyme activity were observed. In nine clinically idiopathic cases, the histological appearances ranged from normal to generalised fibre atrophy or hypertrophy in individual muscles. There was a trend for the mean fibre area to be greater in peroneus longus than in tibialis anterior in six of the idiopathic group of patients. The muscle cross-sectional area on magnetic resonance imaging was correlated closely with the mean fibre area measured on tissue sections. In idiopathic forefoot pes cavus, fibre hypertrophy in peroneus longus (relative to tibialis anterior) may contribute to the cavus deformity. Muscle fibre hyperplasia may contribute to the peroneal muscle enlargement in Friedreich's ataxia. In none of the cases was peroneus longus enlargement due to fat or fibrous tissue replacement.
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  • 136
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    Abdominal imaging 20 (1995), S. 566-568 
    ISSN: 1432-0509
    Keywords: Genitourinary tract abnormalities ; Magnetic resonance imaging ; Pelcic cysts ; Congenital anomalies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gartner duct cysts derive from remnants of the vaginal portion of the mesonephric (Wolffian) ducts. In cases of incomplete regression of these ducts, cysts can develop due to secretory activity [1]. Clinically, those cysts are usually asymptomatic, their size not exceeding 2 cm in diameter. In rare cases with larger cysts, the presence of dyspareunia and problems in obstetric delivery are described [2, 3]. We present a case of a histologically proven symptomatic Gartner duct cyst with a size of 16 ×15×8 cm. To my knowledge, this is the largest Gartner duct cyst ever reported in the imaging literature.
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  • 137
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    Abdominal imaging 20 (1995), S. 379-380 
    ISSN: 1432-0509
    Keywords: Paratesticular ; Fibrous pseudotumor ; Tunica vaginalis ; Magnetic resonance imaging ; Ultrasound ; Hemiscrotum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fibrous pseudotumor is a benign paratesticular tumor that typically presents as a painless mass of the hemiscrotum. Because this tumor can mimic a malignant process, it is usually not diagnosed preoperatively. We describe a case of fibrous pseudotumor of the tunica vaginalis, demonstrating the ultrasound and magnetic resonance image (MRI) appearance with pathologic correlation.
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  • 138
    ISSN: 1432-0509
    Keywords: Adrenal glands ; Adrenocortical adenoma ; Adipose tissue ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of adrenocortical adenoma containing small adipose foci is presented. A small amount of fat within the mass led to an erroneous preoperative diagnosis of myelolipoma. Adrenal adenoma should be included in the differential diagnosis of adrenal mass containing fat.
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  • 139
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    Dysphagia 10 (1995), S. 167-171 
    ISSN: 1432-0460
    Keywords: Dysphagia ; Osteophyte ; Cervical spine ; Magnetic resonance imaging ; Carcinoma ; Surgery ; Deglutition ; Deglutition disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anterior cervical osteophytes impinging upon the pharynx or esophagus constitute a rare cause of dysphagia. In severe cases, surgical removal of these osteophytes can provide symptomatic relief. We describe a patient of this type who failed to improve postoperatively, only to be found subsequently to have a carcinoma of the base of the tongue. To assist other clinicians in evaluating similar patients, and also to emphasize the great utility of modern radiologic techniques in these cases, we propose a diagnostic algorithm that incorporates magnetic resonance or computerized tomographic imaging.
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  • 140
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    CardioVascular & interventional radiology 18 (1995), S. 330-332 
    ISSN: 1432-086X
    Keywords: Aneurysm ; Aortocoronary graft ; Magnetic resonance imaging ; Coronary artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance imaging (MRI) allowed the diagnosis of an atherosclerotic aneurysm of a long-standing aortocoronary saphenous vein graft, initially not depicted by selective coronary graft arteriography due to low flow within the lumen, caused by a stenosis of the proximal graft limb.
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  • 141
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    European spine journal 4 (1995), S. 60-63 
    ISSN: 1432-0932
    Keywords: Arachnoiditis ossificans ; Three-dimensional computed tomography scanning ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histories of two patients with arachnoiditis ossificans leading to severe neurological impairment are presented. Analysis of these cases highlights the importance of three-dimensional (3 D) computed tomography (CT) scanning for the establishment of the diagnosis and in postoperative assessment of this rare disease, whereas magnetic resonance imaging (MRI) is less useful. The neurological function in both cases improved following re-exploration operations in which the whole length of the dural sac covering the intradural ossific lesions was freed totally from external obstructions imposed by the covering laminae.
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  • 142
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    European spine journal 4 (1995), S. 56-59 
    ISSN: 1432-0932
    Keywords: Schmorl's node ; Bone marrow ; Inflammation ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Magnetic resonance imaing (MRI) findings in cases with symptomatic and asymptomatic Schmorl's nodes have been analysed. In all symptomatic cases, the vertebral body marrow surrounding the Schmorl's node was seen as low signal intensity on T1-weighted images and as high signal intensity on T2-weighted images. It was confirmed by histological examination that the MRI findings indicated the presence of inflammation and oedema in the vertebral bone marrow. These MRI findings were not seen in asymptomatic individuals. Inflammatory changes in the vertebral body marrow induced by intraosseous fracture and biological reactions to intraspongious disc materials might cause pain. We postulate that after fracture healing and subsidence of inflammation, the Schmorl's nodes become asymptomatic, in analogy with old vertebral compression fractures. MRI is not only useful in detecting the recently developed Schmorl's nodes but also in differentiating between symptomatic and asymptomatic Schmorl's nodes.
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  • 143
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    European spine journal 4 (1995), S. 257-259 
    ISSN: 1432-0932
    Keywords: Hematoma ; Epidural ; Spinal cord compression ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a spontaneous cervical epidural hematoma treated by anterior corporectomy and arthrodesis is reported. An anterior approach is preferable when an epidural hematoma is anterior to the dural sac and when MRI shows an aspect of old clotted blood that can not be easily evacuated by a posterior laminectomy.
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  • 144
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    European spine journal 4 (1995), S. 357-359 
    ISSN: 1432-0932
    Keywords: Exogenous lumbar spondylodiscitis ; Vertebral body fracture ; Stab wound ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exogenous spondylodiscitis is a rare event and is usually iatrogenic. Non-iatrogenic exogenous spondylodiscitis has been described in the literature following transabdominal gunshot wounds associated with injury to the intestines and spine. Several cases of traumatic meningitis and one of a traumatic meningocele following an injury of the spinal sac have been reported. No report of exogenous spondylodiscitis complicating a stabwound has been published. This is a report of exogenous spondylodiscitis following a paravertebral stabwound with a knife in association with a superior wedge fracture of L2.
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  • 145
    ISSN: 1432-1076
    Keywords: Patent ductus venosus ; Magnetic resonance imaging ; Basal ganglia ; Pulmonary hypertension ; Portosystemic encephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract We report the case of a 13-year-old Japanese boy with a patent ductus venosus. He experienced mild disorientation and hallucination at age 8 years. Hyperammonaemia was discovered at age 12 years. Brain MRI demonstrated multiple intracranial hyperintense lesions, mainly in the globus pallidum, which suggested portosystemic encephalopathy. Patent ductus venosus was demonstrated by abdominal ultrasonography and angiography. Cardiopulmonary investigation revealed pulmonary hypertension. An intracranial hyperintense lesion observed on T1-weighted MRI may be an initial clue for discovering a patent ductus venosus in asymptomatic patients. Conclusion When patent ductus venosus is disclosed, pulmonary hypertension should be sought, as in cases with other portosystemic shunts.
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  • 146
    ISSN: 1432-1076
    Keywords: Key words Patent ductus venosus ; Magnetic resonance imaging ; Basal ganglia ; Pulmonary hypertension ; Portosystemic encephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a 13-year-old Japanese boy with a patent ductus venosus. He experienced mild disorientation and hallucination at age 8 years. Hyperammonaemia was discovered at age 12 years. Brain MRI demonstrated multiple intracranial hyperintense lesions, mainly in the globus pallidum, which suggested portosystemic encephalopathy. Patent ductus venosus was demonstrated by abdominal ultrasonography and angiography. Cardiopulmonary investigation revealed pulmonary hypertension. An intracranial hyperintense lesion observed on T1-weighted MRI may be an initial clue for discovering a patent ductus venosus in asymptomatic patients. Conclusion When patent ductus venosus is disclosed, pulmonary hypertension should be sought, as in cases with other portosystemic shunts.
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  • 147
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    European spine journal 4 (1995), S. 71-76 
    ISSN: 1432-0932
    Keywords: Lumbar spine ; Root pathway ; Magnetic resonance imaging ; Dorsal root ganglia ; Failed back surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In patients with degenerative disease of the lumbar spine, stenosis not only in the entrance zone but also in the mid- and exit zones of the nerve root pathway can occur. With the development of magnetic resonance imaging (MRI), it has become easier to assess stenosis of the root pathway, especially in the mid- and exit zones. T1-weighted sagittal images in the lateral facet plane show the state of the exit zone. I studied the incidence of severe exit-zone stenosis of L3-5 roots in 45 patients aged over 50 years 15 in their fifties, 15 in their sixties, and 15 in their seventies) by MRI and assessed the results on the basis of age, intervertebral disc degeneration, and disc height. I also studied the relationship between clinical symptoms and severe stenosis in both entrance and exit zones of the L4 and L5 roots. The incidence of severe exit-zone stenosis at the L3 root was 20% at all ages. On the other hand, L4 and L5 nerve root stenosis increased with age and severe stenosis affected 70% of L4 roots and 80% of L5 roots in patients in their seventics. The incidence of deformation or disappearance of the dorsal root ganglion (DRG) was 10% or less at L3 and L5 roots, while it was 10% at L4 root. The incidence of severe stenosis both in entrance and exit zones in a single root was 20% at L4 root in all age groups, while it was 19% of patients in their fifties and increased to 29% of patients in their sixties and then 46% of patients in their seveties at L5 root. This study showed the high frequency of root pathway stenosis at L4 and L5 in the degenerative lumbar spine. However, not all patients with exit stenosis suffered from radicular symptoms. Stenosis in the mid- and exit zones of the root pathway has been an important factor in failed back surgery. It seems to be important to determine whether entrance, mid- and exit zone stenosis exist or not in order to clarify the pathological conditions of patients, especially in disorders affecting L4 and L5 nerve roots. T1-weighted MRI images can provide useful information concerning lesions in the mid- and exit zones in the degenerative lumbar spine.
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  • 148
    ISSN: 1432-0932
    Keywords: Magnetic resonance imaging ; herniated disc ; Spinal stenosis ; Oedema ; Venous stasis ; Capillarisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A prospective MRI study was carried out to assess the secondary changes in patients with stenosis and/or herniated disc of the lumbar spinal canal. The study covered 100 patients who had low back and leg pain due to such processes. Of these, 60 patients (group A) had a monoradicular pain pattern, average duration 2 months, due to a herniated lumbar disc. The remaining 40 patients (group B) had acute exacerbation of their chronic low back and leg pain, due to stenosis and herniated disc. As a control group, 5 asymptomatic volunteers with neither stenosis nor herniated disc on MRI were examined. All the patients and volunteers were examined by MRI with several sequences: partial saturation recovery with phase contrast PS (500/10), spin echo SE (500/20), short TI inversion recovery STIR (1900/135/30) and, for the dynamic study, field-gradient echo sequences FAST (50/15): 10 frames in 200 s. In all participants, Gd-DTPA was administered intravenously. In 8 of the patients of group B capillarisation in the protruded nucleus tissue was demonstrated on the PS sequence after Gd-DTPA administration. This tissue also showed decreased signal intensity on the STIR sequence. The capillarisation extended into the centre of the disc. Venous stasis could be verified in all of the 100 patients. An oedema could be verified in all patients of group A; in 20%, its size exceeded that of the herniated disc. In group B, an oedema was seen in only 12 patients. In the control group, no haemodynamic changes were seen. Using MRI, it is possible to define the border between herniated disc tissue and perifocal oedema. In consequence, in cases of acute pain syndromes in patients with herniated discs where oedema is predominant, taking immediate measures to decrease the oedema could be justified. In cases of stenosis, MRI can demonstrate its extent and any associated secondary changes. In patients with multi-level narrowing processes and atypical symptoms, haemodynamic MRI studies may be an important diagnostic tool for finding the symptomatic level.
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  • 149
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    European spine journal 4 (1995), S. 284-290 
    ISSN: 1432-0932
    Keywords: Chiari malformation ; Magnetic resonance imaging ; Scoliosis ; Syringomyelia ; Sensory testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We reviewed the cases of ten patients with scoliosis as the first sign of a cystic spinal cord lesion with the aim of identifying and studying early patient and curve characteristics. All patients were examined with magnetic resonance (MR) imaging of the brain and spinal cord and quantitative thermal testing (QTT). The mean Cobb angle was 22° and the curves were right thoracic in seven patients, left thoracic in two, and left lumbar in one, when first seen for scoliosis. In six patients the cystic lesion was found in routine screening for syringomyelia, which is performed in all cases of congenital and juvenile scoliosis and in adolescent scoliosis before bracing. In four patients, it took up to 17 years following the initial diagnosis of scoliosis before neurologic deterioration warranted MR imaging, disclosing two Chiari I associated syrinxes and two cystic spinal cord tumors. QTT revealed a subelinically decreased sensation in two of the patients with no findings other than scoliosis. It also verified the decreased sensation in all patients in whom neurologic deterioration had complicated the clinical course of their scoliosis. More frequent spinal MR screening of patients with supposed juvenile or adolescent idiopathic scoliosis is indicated, regardless of curve type, to exclude a neurogenic cause. QTT documents subclinical as well as overt decreased sensation, and is valuable in the serial follow-up of these patients to monitor the progress or the response to treatment of the cystic lesion.
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    European spine journal 4 (1995), S. 360-361 
    ISSN: 1432-0932
    Keywords: Infective discitis ; Early diagnosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous reports suggest that MRI changes should be seen within 48h of symptoms arising. We report on two patients with proven discitis at the L5/S1 disc. MRI performed within 60h of the onset of symptoms did not demonstrate evidence of infection and therefore did not confirm the diagnosis of discitis. The reliability of early MRI to confirm infective discitis is questionable. The cases we report on did not display any of the typical changes of discitis on MRI within the first 48h after the onset of symptoms. Absence of typical infective changes on MRI does not necessarily exclude an infection within the disc space.
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  • 151
    ISSN: 1432-1084
    Keywords: Peyronie's disease (IPP) ; Endoluminal ultrasound ; Magnetic resonance imaging ; Corpus spongiosum ; Corpus cavernosum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a 44-year-old male presenting with deviation of the penis during erection. Upon physical and clinical examination the patient did not have the typical findings of Peyronie's disease, therefore he was admitted for further evaluation by conventional sonography, duplex Doppler ultrasound, endourethral ultrasound and magnetic resonance imaging (MRI). Endourethral ultrasound and MRI provided evidence of Peyronie's disease with atypical involvement of the corpus spongiosum and, in addition, demonstrated nonpalpable plaques in the septum of the penis.
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  • 152
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    Intensive care medicine 21 (1995), S. 679-681 
    ISSN: 1432-1238
    Keywords: Fat embolism ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fat embolism syndrome (FES) is one of the most important causes of morbidity and mortality following multiple fractures. Neurological involvement (cerebral fat embolism) has been reported frequently. A case of cerebral fat embolism is reported. While CT scan revealed no abnormalities, MRI, performed in this patient 8 days after trauma, showed relative lowintensity areas on T1-weighted images and high intensity areas on T2-weighted images involving cerebral white matter, corpus callosum and basal ganglia. MRI follow-up (1 and 3 months post-trauma) showed nearly complete resolution of the abnormal signal. MRI seems to be a useful diagnostic tool for detecting and quatifying lesions in fat embolism syndrome.
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  • 153
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    Abdominal imaging 20 (1995), S. 505-515 
    ISSN: 1432-0509
    Keywords: Prostate neoplasms ; Ultrasound ; Doppler ultrasonography ; Radionuclide studies ; Computerized tomography ; Magnetic resonance imaging ; Monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prostate cancer diagnosis and treatment is fast emerging as a major health care issue in the United States. However, there are great uncertainties about the value of specific tests and therapies. Imaging modalities play a major role in the current management of patients with prostate cancer and this role is likely to expand in the future. Transrectal ultrasound is used to identify non-palpable lesions, direct systematic biopsies, determine gland volume and stage prostate cancers. For staging skeletal metastases, the bone scan is acknowledged as the best method, however controversy surrounds its routine use in patients with low prostate specific antigen (PSA) values. Computed tomography (CT) and transrectal ultrasound have limited value in detecting extracapsular disease but CT can be used in conjunction with percutaneous biopsy to identify nodal metastases. The role of Endorectal coil MRI is currently evolving in the wake of a disappointing multiinstitutional trial but MRI still holds the most promise for accurately detecting local extent of prostate cancer. New radiolabeled techniques with monoclonal antibodies and peptide imaging are also having early but promising results. The role of imaging in prostate cancer is continuing to evolve as technology and knowledge about prostate cancer biology improves and health care economics force a more judicious use of imaging resources.
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  • 154
    ISSN: 1432-0584
    Keywords: Key words Myelodysplasic syndrome ; Leukemia ; Magnetic resonance imaging ; Bone marrow biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 47-year-old male patient with myelodysplasia showed increasing values of serum lactate dehydrogenase (up to 3500 units/l) and an increasing blast count. Several biopsies (taken from the posterior iliac crest) revealed marked hypocellularity. In contrast, magnetic resonance imaging of the marrow demonstrated an inhomogeneous distribution of marrow with hypocellular and also large hypercellular areas not detected by cytological and histological analysis. A location for biopsy of hypercellular marrow was provided by T1-weighted and water-selective magnetic resonance imaging. The findings in the patient were compared with those in a matched healthy volunteer.
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  • 155
    ISSN: 1432-0584
    Keywords: Myelodysplasic syndrome ; Leukemia ; Magnetic resonance imaging ; Bone marrow biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 47-year-old male patient with myelodysplasia showed increasing values of serum lactate dehydrogenase (up to 3500 units/l) and an increasing blast count. Several biopsies (taken from the posterior iliac crest) revealed marked hypocellularity. In contrast, magnetic resonance imaging of the marrow demonstrated an inhomogeneous distribution of marrow with hypocellular and also large hypercellular areas not detected by cytological and histological analysis. A location for biopsy of hypercellular marrow was provided by T1-weighted and water-selective magnetic resonance imaging. The findings in the patient were compared with those in a matched healthy volunteer.
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  • 156
    ISSN: 1432-0509
    Keywords: Magnetic resonance imaging ; Flow dynamics ; Portal vein ; Liver cirrhosis ; Chronic hepatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In patients with diffuse liver disease, the portal flow dynamics change markedly in accordance with disease progression and would provide a useful index of progression of stage. Methods: Portal blood flow (PBF) was measured by phase contrast magnetic resonance imaging (MRI) in 21 patients with diffuse liver disease and 20 healthy volunteers. The MRI method was validated by a flow phantom study. The mean PBF could be measured in 6.8 min without breath-holding. Results: Doppler ultrasound measurements of PBF volume were obtained reproducibly in all the healthy volunteers and were shown to correlate with the MRI values (Doppler: 12.5 ±3.2 cm3/s, MRI: 12.0 ± 3.3 cm3/s; mean ± SD). The PBF volume of patients with chronic hepatitis showed no significant difference from that of the healthy volunteers. In patients with liver cirrhosis, the PBF volume ranged from 5.01 to 32.3 cm3/s. A significant increase in PBF volume was caused in one patient by massive intrahepatic shunting and a significant decrease was caused in two patients by massive extrahepatic shunting. Conclusions: The measurement of PBF by phase contrast MRI is clinically useful in predicting intrahepatic or extrahepatic shunting in patients with liver cirrhosis, and may be of value in detecting the progression of stage in diffuse liver diseases.
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  • 157
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    Abdominal imaging 20 (1995), S. 176-178 
    ISSN: 1432-0509
    Keywords: Magnetic resonance imaging ; Neurofibroma ; Prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pelvic neurofibromatosis is a rare disease and rarely involves the prostate. A 19-year-old male presented with irritative and obstructive voiding symptoms. Magnetic resonance imaging showed a large mass extending from the sacral promontory to the perirectal and perivesical spaces and to the proximal root of the penis. The mass also involved the prostate. The characteristics of the mass were highly suggestive for neurofibroma. Prostate biopsy showed neurofibroma, and the immunohistochemistry stain for S-100 protein was positive.
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    Abdominal imaging 20 (1995), S. 486-488 
    ISSN: 1432-0509
    Keywords: Rupture, uterine ; Pregnancy, complications ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gravid uterine rupture can be a difficult diagnosis, both clinically and radiologically. Ultrasound has been successful in detection of some indirect signs of uterine rupture but thus far has shown little success in demonstrating the myometrial defect. We present the MR findings in a case of gravid uterine dehiscence in which the actual uterine wall defect was well demonstrated. Gross pathologic correlation is provided.
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    Skeletal radiology 24 (1995), S. 117-121 
    ISSN: 1432-2161
    Keywords: Glenoid labrum ; Magnetic resonance imaging ; Three-dimensional volume scan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to assess the accuracy of three-dimensional (3D) magnetic resonance imaging (MRI) reformation in the evaluation of tears of the glenoid labrum complex (GLC). Fifty-five shoulders were evaluated by MRI using standard spin-echo sequences. Gradient-refocused-echo axial projections were used to assess the GLC on the two-dimensional (2D) studies. Three-dimensional Fourier transform multiplanar gradient-recalled imaging with a resolution of 0.7 mm was also performed in all patients. Independent analyses of the anterior and posterior labra were performed in a blinded manner for both the 2D and 3D studies by three experienced musculoskeletal radiologists. Observations of the imaging studies were compared with the videoarthroscopic findings. The appearance of the GLC was rated on a scale of 0 to 4 (0–2=normal, 3, 4=abnormal or torn). The diagnostic confidence was averaged from the three reader's scores. Anterior labral tears were effectively detected with sensitivities of 89% and 96% and specificities of 96% and 100% (P〈0.0001) for the 2D and 3D studies, respectively. For posterior labral tears, the sensitivity and specificity of the 2D method were 47% and 98%, respectively. The sensitivity and specificity of the 3D volume sequence were 53% and 98%, respectively. The lower sensitivity of both imaging methods for detecting posterior labral tears may be influenced by the smaller number (n=5) of arthroscopically confirmed cases in our study and reflects the difficulty of viusalizing the posteroinferior borders of the GLC with present MRI techniques.
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  • 160
    ISSN: 1432-2161
    Keywords: Alveolar soft part sarcoma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective The objective of this study was to analyze the characteristics of alveolar soft part sarcoma using magnetic resonance imaging (MRI). Design MRI studies of pathologically proven alveolar soft part sarcomas (ASPS) in ten patients were reviewed and compared with computed tomographic (CT) studies and angiograms. Patients Ten patients presented with a soft tissue mass of the extremities, neck, axilla, or buttocks. MR images were obtained in all patients prior to surgical intervention, chemotherapy, or irradiation. Results and Conclusion Although most soft tissue sarcomas are isointense relative to muscle on MRI T1-weighted images (T1WI), nine of the ten alveolar ASPS in the present study demonstrated high signal intensity on both T2 and T1WI. Flow voids were observed both at the core and at the margins of the tumors studied. Recognition of these characteristic MRI findings may lead to the early diagnosis of ASPS, especially when the clinical presentation is that of a slow-growing soft tissue mass in a young adult patient.
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    Astrophysics and space science 224 (1995), S. 81-84 
    ISSN: 1572-946X
    Keywords: Chemistry ; Depletions ; Shocks ; IRAS 05338-0624 ; NGC 1333 IRAS 4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract High resolution interferometer and single-dish observations of young, deeply embedded stellar systems reveal a complex chemistry in the circumstellar environments of low to intermediate mass stars. Depletions of gas-phase molecules, grain mantle evaporation, and shock interactions actively drive chemical processes in different regions around young stars. We present results for two systems, IRAS 05338-0624 and NGC 1333 IRAS 4, to illustrate the behavior found and to examine the physical processes at work.
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  • 162
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    Astrophysics and space science 233 (1995), S. 125-137 
    ISSN: 1572-946X
    Keywords: Interstellar Medium ; Dark Clouds ; Chemistry ; Bistability ; C-shock Waves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Shock waves perturb the chemical state of the interstellar gas. We consider the effects of C-shocks on the composition of molecular clouds, for a range of values of the pre-shock gas density and magnetic induction. The time required to re-establish equilibrium in the post-shock gas depends on the initial conditions and can become very large. The significance of the two known chemical phases of dark clouds and of bistability is considered in this context.
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  • 163
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    Astrophysics and space science 233 (1995), S. 161-164 
    ISSN: 1572-946X
    Keywords: Stars ; Chemistry ; Diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have assessed the role of diffusion in determining chemical abundances in molecular interface regions. Chemical models have been developed which include the appropriate diffusion terms and that are appropriate to a narrow diffusion region (∼0.01pc) that may exist at the interface between a dark core and a hot, shocked T-Tauri wind. We have assumed pressure balance throughout and have calculated the chemical abundances as functions of time and position through the interface. The results show that significant enhancements of detectable molecules/transitions are expected (e.g. CO J=6→5, OH and CH). Using a realistic value of the diffusion coefficient a diffusive region of dimension 0.01pc may be established within about 104 years. In general it seems likely that diffusion processes are highly significant on these and smaller lengthscales.
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  • 164
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    Journal of cancer research and clinical oncology 121 (1995), S. 189-191 
    ISSN: 1432-1335
    Keywords: Thyroid carcinoma ; Cervical cord compression ; Magnetic resonance imaging ; Radioiodine scan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cervical cord compression due to local extension of differentiated thyroid carcinoma (DTC) is an extremely rare condition and, to our knowledge, only one case has been reported in the literature. Among 256 patients with DTC treated at our hospital, we have observed 3 cases of spinal injury due to local extension of DTC. A Brown-Séquard syndrome was detected at physical examination in 2 cases. In both patients, cervical cord compression precipitated a fatal event. In the remaining patient, a radiculo-pathy C5–C7 was observed. Magnetic resonance imaging was very successful in outlining the mass, clearly differentiating the extrinsic invasion from a metastasis, and allowing the surgical possibilities to be evaluated. Poor cervical uptake of131I was observed on scans performed in two cases, suggesting a certain degree of cell dedifferentiation. We suggest that cervical spinal injury due to local extension of DTC may be an underreported complication of DTC that seems to condition the patient's outcome. Careful neurological examination is warranted in patients with DTC at stages III–IV and magnetic resonance imaging must be performed when spinal injury is suspected.
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  • 165
    ISSN: 1432-1459
    Keywords: Acquired immune deficiency syndrome ; Cerebral toxoplasmosis ; Progressive multifocal leucoencephalopathy ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the results of a hospital-based study of 188 consecutive patients seropositive for the human immune deficiency virus type 1 (HIV-1) who presented in a 4-year period (1988–1991) with possible signs or symptoms of first-ever central nervous system disease. Confirmed diagnoses were cerebral toxoplasmosis in 47 patients (25.0%), HIV-1 encephalopathy in 19 (10.1%), progressive multifocal leucoencephalopathy (PML) in 9 (4.8%), cerebral lymphoma in 1 (0.5%), and other conditions in 9 patients (4.8%). Seventy-three subjects (38.8%) showed focal brain lesions on initial computed tomography or magnetic resonance imaging, which were assessed prospectively. Positive predictivity for toxoplasmosis was 100% if multiple lesions occurred in combination with mass effect or contrast enhancement (23 patients), or if at least one space-occupying or enhancing lesion was located in the basal ganglia or the thalamus (26 patients). Solitary lesions with mass effect or contrast enhancement were seen in 26 patients and were caused by cerebral toxoplasmosis in 22 (84.6%). Eight of the 9 PML patients presented with one or more non-enhancing, non-mass lesions, although the predictive value of this pattern was low (47.1% for PML). Thus, in our epidemiological context, certain imaging findings in HIV-1-seropositive patients were highly predictive of cerebral toxoplasmosis. This may differ from findings from other parts of the world where cerebral toxoplasmosis may be less prevalent among HIV-1-infected individuals.
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  • 166
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Vaccination ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the possible effects of influenza vaccinationon disease activity in multiple sclerosis (MS). Six patients were evaluated clinically during the year preceding and the year following influenza vaccination. Gadolinium-enhanced magnetic resonance imaging (Gd-MRI) was performed one day before and at days 15 and 45 after vaccination. Cumulatively, we did not observe increases in clinical or MRI disease activity following vaccination, with the exception of one case. This was the patient with the highest clinical disease activity during the year preceding vaccination. These results support and supplement previous observations, indicating that influenza vaccination is a safe procedure in multiple sclerosis. Nevertheless, it should be used with caution in patients with active/progressing disease.
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  • 167
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    Journal of neurology 242 (1995), S. 174-177 
    ISSN: 1432-1459
    Keywords: Retinal vasculitis ; Magnetic resonance imaging ; Multiple sclerosis ; Optic neuritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ten patients with clinically isolated idiopathic retinal vasculitis who had a positive family history for multiple sclerosis (MS) or positive typing for HLA B7 underwent magnetic resonance imaging (MRI) of brain and optic nerves in order to establish the frequency of clinically silent lesions. Brain MRI was normal in seven and abnormal in three: one had a single small white matter lesion, two had extensive white matter abnormalities resembling those seen in MS. In two patients a lesion was shown in the optic nerve. These findings suggest that a minority of patients with idiopathic retinal vasculitis have disseminated central nervous system lesions characteristic of MS, the frequency of such changes being less than in patients with isolated optic neuritis.
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  • 168
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    Journal of neurology 242 (1995), S. 195-202 
    ISSN: 1432-1459
    Keywords: Medullary syndrome ; Magnetic resonance imaging ; Brainstem infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There are two major vascular syndromes of the medulla oblongata: the medial and the lateral. The medial medullary syndrome is characterized by the triad of ipsilateral hypoglossal nerve palsy with contralateral hemiparesis and loss of deep sensation. Lateral medullary infarction commonly presents with Homer's syndrome, ataxia, alternating thermoanalgesia, nystagmus, vertigo and hoarseness. Combinations of the two major syndromes occur as bilateral medial medullary, hemi-medullary and bilateral lateral medullary syndromes. Each of these syndromes frequently manifests with incomplete or atypical findings depending on the extent of the lesion. Magnetic resonance imaging has been useful in the clinical diagnosis of medullary infarctions. The site of the lesion may help predict the arteries involved.
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  • 169
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    Journal of neurology 242 (1995), S. 231-238 
    ISSN: 1432-1459
    Keywords: Carotid artery disease ; Dissection ; Magnetic resonance imaging ; Ultrasonics ; Anticoagulants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract First symptoms and initial clinical, ultrasonographic and neuroradiological findings ascertained a mean of 5.6 days (SD = 5.6 days), 7.7 days (7.0), and 11.2 days (8.0) after symptom onset were analysed in 44 patients who suffered a spontaneous internal carotid artery dissection (ICD) verified by magnetic resonance imaging, angiography, or both. Common symptoms signalling dissection were unilateral headache in 68%, transient ischaemic attack in 20%, and cerebral infarction in 9%. Severe pain preceded cerebral ischaemia by more than 3 days in 60% of those patients who eventually suffered a stroke. However, only 2 were admitted because of pain alone and 33 for evolving neurological deficits. During the first month, ipsilateral severe headache occurred in 89%, neck pain in 36%, ipsilateral cerebral ischaemia in 82%, ocular ischaemia in 16%, oculosympathetic palsy in 48%, and cranial nerve palsy in 5%. Recent “trivial” head or neck trauma was elicited in 41 %. Doppler and duplex sonography confirmed the clinical suspicion of ICD in 91.5% and in 96% of those with a significant stenosis or occlusion. MRI demonstrated a thickened vessel wall in all 33 imaged carotid dissections and a mural haematoma in 30. None of the 32 patients who received anticoagulant treatment subsequently deteriorated. Monitoring anticoagulant treatment with ultrasonographic follow-up studies demonstrated recanalization in 70% and persistent occlusion in 30%. The results demonstrate that familiarity with the initial symptoms, especially headache, and performance of an ultrasonographic study without delay are the cornerstones of an early diagnosis. Immediate anticoagulation to prevent fatal cerebral embolism seems the appropriate treatment when intracranial dissection is excluded, although its efficacy has not yet been proven by a controlled study.
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  • 170
    ISSN: 1432-1459
    Keywords: Neuro-Behçet's disease ; Paroxysmal dysarthria-ataxia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The paroxysmal attacks which are frequently encountered in the course of multiple sclerosis (MS) are characterised by their sudden onset, short duration and frequent repetition. Such attacks have also been reported in some other diseases affecting the CNS, such as systemic lupus erythematosus. However, to our knowledge, they have not been reported in neuro-Behçet's disease (NBD). A patient with NBD who developed paroxysmal dysarthriaataxia attacks is presented, and the similarity of some clinical, laboratory, and neuroradiological aspects of NBD and MS are discussed with special emphasis on magnetic resonance imaging findings.
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  • 171
    ISSN: 1432-1459
    Keywords: Angiography ; Magnetic resonance imaging ; Ultrasonography ; Vertebral artery dissection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous vertebral artery dissection (VAD) is a rare but well-known cause of cerebrovascular disease and is often difficult to diagnose even using conventional arteriography. While noninvasive tests such as Doppler ultrasonography and magnetic resonance imaging (MRI) have failed to provide reliable criteria for the diagnosis of VAD, the diagnostic value of magnetic resonance angiography (MRA) has not yet been undetermined. To establish the reliability of a combined noninvasive approach, 11 patients were prospectively examined for VAD by means of colour-coded duplex studies, MRI and three-dimensional time-of-flight MRA prior to conventional angiography. Among 11 patients with VAD suspected clinically as well as on Doppler ultrasonography, angiography confirmed the diagnosis in seven patients but found a vertebral artery occlusion in three and a vertebral artery stenosis in one. The combination of MRI and MRA findings led to the correct diagnosis of dissection in three patients, of vertebral artery occlusion in three patients, and of vertebral artery stenosis in one. VAD was misinterpreted as vertebral artery occlusion in four patients. Doppler ultrasonography is a valuable screening method for the detection of vertebral artery pathologies. The diagnosis of VAD can only be established if a typical intramural vessel wall haematoma is seen on T1-weighted MRI in combination with MRA findings of irregular artery stenosis or occlusion.
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  • 172
    ISSN: 1432-1459
    Keywords: Acute myelopathy ; Magnetic resonance imaging ; Evoked potentials ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain and spinal cord magnetic resonance imaging (MRI), multimodal evoked potentials (EPs) and cerebrospinal fluid (CSF) analysis were performed in 27 patients with acute myelopathy of unknown aetiology (AMUA), to detect the diagnostic and prognostic values of paraclinical tests at presentation. Spinal cord MRI was abnormal in 56% and brain MRI in 33% of the patients. Visual EPs were abnormal in 7%, median somatosensory EPs in 17%, tibial somatosensory EPs in 56% and motor EPs in 35% of the cases examined. Brain-stem acoustic EPs were normal in all the patients. CSF oligoclonal bands (OBs) were detected in 30% of cases. The patients were divided into subgroups according to the short-term clinical outcome (complete, partial or absent recovery). There were no significant differences among the three groups as regards MRI findings. Patients with complete recovery showed a significantly lower frequency of tibial somatosensory EP and motor EP abnormalities. According to the paraclinical findings at onset and on the basis of a long-term clinical follow-up (mean duration 24 months), 6 patients were diagnosed as having clinically definite multiple sclerosis, while 21 did not develop further neurological disturbances. Only the presence of CSF OBs was significantly more frequent in patients with definite multiple sclerosis. Our study indicates that EPs exploring spinal cord function are more powerful than spinal MRI for predicting the short-term outcome of AMUA, while the combined use of brain MRI and CSF OBs has the highest negative predictive value for the subsequent development of clinically definite multiple sclerosis.
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  • 173
    ISSN: 1432-1459
    Keywords: Friedreich's ataxia ; Fixation instability ; Oculomotor abnormalities ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eye movements were studied in 13 patients with Friedreich's ataxia and correlated with MRI findings to investigate whether oculomotor abnormalities can be traced to cerebellar disturbances in this disease. One of the most prominent eye signs was fixation instability (square-wave jerks, SWJ.). Besides SWJ the patients showed various combinations of cerebellar, vestibular and brain-stem oculomotor signs. Our patients did not comprise a homogeneous group with regard to their oculomotor findings. There was no correlation between the severity of any of the so-called cerebellar oculomotor disturbances and the number of SWJ. We tried to correlate the extent of oculomotor disturbances with floccular atrophy and atrophy of the dorsal vermis on MRI in seven of the patients. None of the oculomotor features (including SWJ) correlated with flocculus or dorsal vermis size. Furthermore, floccular and vermal measurements on MRI were normal. Accordingly, we think it unlikely that the oculomotor disturbances, including SWJ, are attributable to cerebellar pathology per se.
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  • 174
    ISSN: 1432-1459
    Keywords: Magnetic resonance imaging ; Interobserver agreement ; Medial temporal lobe atrophy ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We conducted an interobserver study to assess agreement on visual rating of medial temporal lobe atrophy on coronal T1-weighted MRI. A total of 100 studies of elderly individuals, using two different MRI techniques (spin echo and inversion recovery sequences), were analysed by four raters (three neurologists and one neuroradiologist) using a five-point rating scale. Complete agreement was found in 37% of the total sample. Interobserver agreement as expressed by kappa values was 0.44 (95% CIl0.34–0.54) and 0.51 (95% Cl=0.41–0.61) for the two techniques. After dichotomizing medial temporal lobe atrophy into present or absent, a post hoc analysis revealed higher complete agreeement (70%), with kappa values of 0.59 (95% Cl=0.51–0.67) and 0.62 (95% Cl=0.48–0.075), for the two techniques (all four raters). From this study we conclude that visual rating of medial temporal lobe atrophy on MRI in the coronal plane yields fair to good agreement among observers. We recommend this type of visual rating for use in clinical settings when a quick judgement on the presence of medial temporal lobe atrophy is needed.
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  • 175
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    Journal of neurology 242 (1995), S. 596-598 
    ISSN: 1432-1459
    Keywords: Repetition ; Arcuate fasciculus ; Conduction aphasia ; Magnetic resonance imaging ; Cortical stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract According to the traditional model of language organization, repetition deficits arise following damage to the arcuate fasciculus of the dominant hemisphere (conduction aphasia). Conduction aphasia may result from lesions that spare the arcuate fasciculus. However, these patients have atypical language organization. We describe a man with normal language architecture who underwent a resection of the anterior portion of his arcuate fasciculus and retained his ability to repeat words and sentences. We propose that the arcuate fasciculus is not necessary for speech repetition by the lexical route.
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  • 176
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    Journal of neurology 242 (1995), S. 689-694 
    ISSN: 1432-1459
    Keywords: Cardiac myxoma ; Aneurysm ; Dementia ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From 1980 to 1992 we followed 12 patients with cardiac myxomas for an average of 4.4 years (8 months–11 years). Presenting symptoms were neurological in four patients (hemiparesis, aphasia, visual field deficits, progressive dementia or vertigo), progressive dyspnoea in six, pulmonary embolism in one, and peripheral arterial or renal emboli in three. The diagnosis was suspected clinically in 11 patients. It was confirmed by echocardiography in ten and by thoracic CT in one. All these patients had cardiac surgery. One diagnosis was made at autopsy; the patient died unexpectedly during surgery for emboli to the leg arteries. At follow-up, two additional patients had died, one from myocardial infarction and one from rhabdomyosarcoma. Only one of the nine surviving patients had recurrent symptoms after cardiac surgery. His dementia continued to progress. The patients without new symptoms after cardiac surgery had normal MRI of the brain or residual ischaemic lesions. MRI of the patient with progressive dementia showed multiple cerebral lesions with a bright centre and a dark rim on T1- and T2-weighted spin-echo images. On CT there were many calcified lesions. CT, MR angiography and contrast angiography revealed multiple fusiform aneurysms. The rare occurrence of progressive neurological symptoms after myxoma resection with multiple cerebral lesions and aneurysms should suggest myxoma metastases to the brain.
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  • 177
    ISSN: 1573-2622
    Keywords: Cerebral dyschromatopsia ; Color pattern visual evoked cortical potentials ; Color vision ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined a 74-year-old man because of difficulty seeing green and the presence of prosopagnosia. His visual acuity was 0.8 in both eyes. He was not congenitally color blind, and there was no family history of color blindness. A left superior homonymous quadrantanopsia was found. The dyschromatopsia was identical in both eyes. The patient showed red-green deficiency on testing with Ishihara plates a deutan defect with Tokyo Medical College plates, strong blue-yellow defects and medium red-green defects with Standard Pseudochromatic Plates II and a tritan defect with the Panel D-15. He failed the New Color separation test with scores of 160 and could not carry out the Farnsworth-Munsell 100-hue test, but his color naming test results were normal. Visual evoked cortical potentials to black-and-white checkerboard and color pattern reversal (Red and Blue-Green, Green and Red-Purple, Purple and Yellow-Green: isochromatic paired checks) stimuli were normal. Bilateral inferior occipital lesions were found by computed tomography and T2-weighted magnetic resonance imaging. Our findings suggested that luminance and color channels up to area 17 in our patient were intact. We believe that our patient's acquired cerebral dyschromatopsia is rare.
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  • 178
    ISSN: 1590-3478
    Keywords: Mongolian gerbil ; Hemispheric ischemia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Nella presente ricerca abbiamo valutato nel gerbillo della Mongolia l'evoluzione e la gravità del danno ischemico dopo chiusura permanente di una delle arterie carotidi comuni (ACC) mediante RM convenzionale (RM con immagini pesate in T2) e analisis istologica. Subito dopo la chiusura di una ACC, gli animali hanno presentato una differente sintomatologia clinica. La mortalità (46%) rilevata entro le prime 48 ore è stata considerata un indice di “sensibilità allostroke”. Gli animali “resistenti allostroke” hanno mostrato un'ampia variabilità sia nell'evoluzione che nella gravità del danno ischemico. L'iperintensità del segnale e la negatività all'esame RM osservate entro 30 ore dalla legatura della ACC non sempre correlavano con il danno istologico cerebrale rilevato a 14 giorni. Una stretta correlazione è stata stabilita tra le immagini pesate in T2 e ottenute dopo 30 ore dalla occlusione della ACC e la neuropatologia. Infatti, i gerbilli negativi alla RM non presentavano lesioni, mentre un'alterazione di segnale era sempre predittiva di danno ischemico. Inoltre l'esame RM tardivo ha evidenziato dilatazione ventricolare. L'istopatologia ha dimostrato che il danno ischemico differiva tra i gerbilli “resistenti allo stroke” e spesso era bilaterale. Questo studio conferma la diversa suscettibilità all'infarto emisferico dopo chiusura permanente di una ACC e suggerisce che la RM convenzionale potrebbe essere un metodo non invasivo utile per 1) identificare e/o selezionare gli animali inclini a maturare danno ischemico e 2) monitorare l'efficacia di un trattamento terapeutico senza sacrificare gli animali.
    Notes: Abstract In the present investigation, we estimated both the evolution and the severity of ischemic damage following unilateral carotid occlusion (UCO) in Mongolian gerbils by using conventional magnetic resonance imaging (MRI, i.e. T2 weighted imaging) and histological techniques. Immediately after UCO, the animals showed different clinical effects. The mortality (46%) detected within the first 48h was considered an “stroke-sensitivity”; the “stroke-resistant” animals showed wide variability in terms of both temporal evolution and the extent of ischemic damage. The signal hyperintensity and negative MRI observed during the first 30h after UCO did not always correlate with the cerebral damage presented after 14 days, although a close correlation was established between the T2 weighted images taken more than 30h after UCO and neuropathology: the gerbils negative to imaging showed no morphological changes, whereas an enhanced signal was always prognostic of ischemic injury. Moreover, late MRI documented ventricular dilatation. Histopathology showed that the ischemic damage differed among the stroke-resistant gerbils and was often bilateral. The present study confirms the differences in gerbil susceptibility to hemispheric infarction after permanent UCO and suggests that conventional MRI may be a useful non-invasive method for i) identifying the stroke-resistant animals prone to mature ischemic injury and ii) monitoring the evolution of therapeutic efficacy without sacrificing animals.
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  • 179
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    Langenbeck's archives of surgery 380 (1995), S. 203-206 
    ISSN: 1435-2451
    Keywords: Magnetic resonance imaging ; Cervical spine ; Titanium implant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Vorstellung von 10 Patienten, von denen sich 8 Rückenmarkschädigungen und 2 radikuläre Beeinträchtigungen im Rahmen von Dislokationsverletzungen der HWS zuzogen und die nach Stabilisierungsoperationen im Zeitraum von 2 Tagen bis 8 Monaten mittels MRT abgekldrt werden, verfolgt das Ziel, die Einsatz-und Aussagembglichkeiten dieser nicht-invasiven Methode darzustellen. Bei 2 Patienten mit schwerem Schädelhirntrauma konnte die Ursache für die Querschnittsläsion eindeutig einer Rückenmarkschädigung zugeordnet werden. Ebenso korrelierten schwere Binnenschäden des Rückenmarks, wie intramyeläre Hämatome oder Transsektionen, mit kompletten Querschnittsläsionen. Alleinige Rückenmarködeme traten mit einer inkompletten Querschnittsläsion auf. Die Beurteilung des Ruckenmarks nach postoperativer neurologischer Verschlechterung ermöglicht den Ausschluß einer Rückenmarkkompression als Ursache. Die MRT eignet sich auch zur lebenslangen Beurteilung von Rückenmark- und HWS-Veränderungen. Somit kann das Rückenmark mit der postoperativen MRT in Problemfällen und zur Prognoseerstellung herangezogen werden.
    Notes: Abstract We present the cases of ten patients who underwent postoperative magnetic resonance assessment after dislocation injuries of the cervical spine and treatment with anterior interbody fusion and titanium implants. Eight patients had spinal cord injuries and two had nerve root disorders. In two patients who had intracranial haematomas and dislocation fractures of the cervical spine, MRI proved useful for identification of parenchymal spinal cord injuries as the reason for transverse lesions. Severe MR findings of the parenchymal spinal cord injuries (haematoma or transection) correlated with complete transverse lesions (4 patients) and oedema of the spinal cord, with incomplete transverse lesions (3 patients). MR enables us to examine the spinal cord after operations to ensure that correct spinal cord decompression has been achieved (3 patients). MRI is useful for detecting disc protrusion or chronic spinal stenosis in patients with titanium implants. All in all, MRI is an important modality in the evaluation of the posttraumatic cervical spine.
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  • 180
    ISSN: 1435-2451
    Keywords: Hyperextension injury ; Lower cervical spine ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Kasuistik beinhaltet 5 Patienten mit Hyperextensionsverletzungen der unteren Halswirbelsäule (HWS). Die dorsale Instabilität in einem Bewegungssegment war im HWS-Röntgen nicht eindeutig zu verifizieren. Die Funktionsaufnahmen zeigten 4mal eine leichte Retrospondylolisthesis von 2 mm and 1mal eine mäßige Erweiterung des Zwischenwirbelraums. Die Mangnetresonanztomographie (MRT) erbrachte bei allen 5 Patienten durch den Nachweis eines ausgeprägten Diskusprolapes, zusätzlich bei 2 Patienten durch die Darstellung eines intramyelären Hämatoms and bei 1 Patienten durch das Auftreten eines Rückenmark(RM)-Ödems, indirekte Hinweise auf ein dorsal instabiles Bewegungssegment.
    Notes: Abstract Five patients with hyperextension injuries and dorsally instable motion segments are presented. In the diagnosis of posterior instabilities plain roentgenograms demonstrated no characteristic signs of an injured cervical spine. Flexion and extension views detected a mild degree (2 mm) of retrospondylolisthesis in four cases and a widened disc space in one case. In all five patients the MR findings that made use suspect a posterior unstable motion segment were disc protrusions; in addition, in two patients these was hemorrhage in the spinal cord and in one patient cord edema.
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  • 181
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    European archives of psychiatry and clinical neuroscience 245 (1995), S. 142-144 
    ISSN: 1433-8491
    Keywords: Magnetic resonance imaging ; Schizophrenia ; Asymmetry of the lateral ventricle ; Age at the onset of illness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between lateral ventricular size or its asymmetry and age at the onset of schizophrenia was investigated in 20 schizophrenic patients diagnosed according to DSM-III-R criteria. The ventriclebrain ratio (VBR) was determined using three transaxial slices of magnetic resonance image (MRI) and asymmetry of the lateral ventricle was evaluated from the laterality index of the lateral ventricular area: (left-right/lef+right)×100. Each age at the onset of the prodromal and active phase according to DSM-III-R criteria was determined for each patient. The results showed that asymmetry of the ventricle, but not VBR, was significantly correlated inversely with age at the onset of both the prodromal phase and active phase. Neither asymmetry nor VBR correlated with the duration of illness, age at MRI scanning, or severity of clinical symptoms. It would thus appear that greater asymmetry of the ventricle is associated with earlier onset of schizophrenia.
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  • 182
    ISSN: 1433-7347
    Keywords: Hill-Sachs lesion ; Magnetic resonance imaging ; Arthroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract A double-blind prospective study was done with 15 patients with anterior shoulder instability to determine the diagnostic efficacy of magnetic resonance (MR) imaging versus arthroscopy in the evaluation of chondral or osteochondral lesions of the humeral head. MR produced 6 true positives, 5 true negatives and 4 false negatives, and its accuracy and sensitivity were 60% and 87%, respectively, whereas arthroscopy gave 8 true positives, 5 true negatives and 2 false negatives, with a sensitivity of 80% and an accuracy of 87%. All lesions diagnosed with either method were regarded as positive by definition, with the result that the specificity was always 100%. The differences in diagnosis sprang from the false negatives. The 40% discrepancy between the two methods was probbly due to our distinction in MR between intra- and extraarticular osteochondral lesions. In the first group (the 4 MR false negatives), there were three instances of firstdegree intra-articular lesion and one diagnostic error (third-degree lesion). In the second (the 2 arthroscopy false negatives), the lesions were of the extra-articular type. It is thus advisable to employ both of these methods to ensure the correct diagnosis of a Hill-Sachs lesion, and hence the correct choice of treatment.
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    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 206-208 
    ISSN: 1434-4726
    Keywords: Laryngeal cancer ; Tumor staging Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This retrospective study quantitatively assessed the effects of magnetic resonance imaging (MRI) and computed tomography (CT) on the staging of laryngeal cancer. A blind comparison between CT and MRI was made in a group of previously untreated patients with squamous cell carcinomas of the larynx. From June 1992 to November 1993, 29 patients were eligible for study. Of these, 14 patients (48%) had supraglottic lesions, 11 patients (40%) had glottic lesions and 4 patients (14%) had both. No subglottic lesions were seen. The data suggest that clinical staging of laryngeal tumors is inadequate. MRI proved superior to CT for staging tumors, especially those confined to the supraglottis. Nevertheless, clinically staged T1 or T2 lesions could be adequately assessed by CT alone. Findings also indicate that MRI should be reserved for T3 or T4 clinically staged lesions. Furthermore, most nodal disease can be staged by CT.
    Type of Medium: Electronic Resource
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  • 184
    ISSN: 1619-7089
    Keywords: Endodermal sinus tumor ; Ovarian tumor ; Positron emission tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of recurrent endodermal sinus tumor.of the ovary that was identified and/or clearly depicted by computed tomography, magnetic resonance imaging, and positron emission tomography. The potential roles of various imaging modalities in the detection of recurrent endodermal sinus tumor are discussed.
    Type of Medium: Electronic Resource
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  • 185
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    Springer
    European journal of nuclear medicine 22 (1995), S. 1069-1072 
    ISSN: 1619-7089
    Keywords: Gallium scintigraphy ; Cerebrotendinous xanthomatosis ; Xanthoma ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a patient with cerebrotendinous xanthomatosis, a rare familial sterol storage disease, increased uptake of gallium-67 was observed in the tendon xanthomas. This is considered to have resulted from the tumour-like proliferation of histiocytic cells in the xanthomas. Abnormalities in the white matter of the cerebellum and the brain stem observed by X-ray computed tomography and magnetic resonance imaging were not detected by67Ga scintigraphy, possibly due to the small size of the CNS lesions.
    Type of Medium: Electronic Resource
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  • 186
    ISSN: 1439-6327
    Keywords: Brain ; Altitude ; Hypoxia ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to look for anatomical changes in climbers' brains, using magnetic resonance imaging (MRI), after extremely high-altitude climbs and to relate them to possible associated risk factors. Clinical history, neurological examinations and MRI were carried out on a group of nine climbers before and after climbing to over 7500 m without the use of supplementary oxygen. None of the subjects showed any neurological dysfunctions. In five climbers MRI abnormalities (high signal areas, cortical atrophy) were observed before the expedition. After the descent, two of them showed new high intensity signal areas recorded by MRI. Both subjects suffered severe neurological symptoms during the climb. The present study suggested that the brain changes observed by MRI could be related to the severity of clinical events at high altitude. However, we do not know the exact meaning of such MRI findings or the reason for their location, predominantly in posterior regions of the brain. The new evidence that a high percentage of climbers show MRI brain abnormalities, and especially the appearance of changes after the ascent, reinforces the possibility of a potential neurological risk in high-altitude climbing.
    Type of Medium: Electronic Resource
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  • 187
    ISSN: 1619-7089
    Keywords: Diastolic function ; Constrictive pericarditis ; Radionuclide angiography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Constrictive pericarditis presents with a suggestive clinical picture, and its diagnosis is based on a haemodynamic pattern revealing impaired ventricular filling. In this study of 15 patients with pure isolated constrictive pericarditis, we attempted to evaluate the diagnostic value of two non-invasive methods not usually employed in this indication: radionuclide angiography (RNA) and magnetic resonance imaging (MRI). Whilst RNA permits analysis of the functional pattern of the global and segmental left ventricular filling impairment, MRI allows measurement of the thickness of the pericardium. RNA revealed increased early diastolic filling as evidenced by a shorter one-third filling time (TFl/3;P〈0.0001 with respect to a normal population), a higher peak filling rate (PFR;P〈0.01) and its early occurrence (P〈0.001), increased one-third and mid diastolic filling fractions (P〈0.01), and the ratio of the PFR over the peak ejection rate (P〈0.01). During late diastole, the atrial filling fraction decreased (NS). The patients with constrictive pericarditis also showed a decrease in the physiological filling asynchrony, as assessed by segmental evaluations. Seven patients underwent MRI. The pericardium was thickened in all the patients, varying from 6 to 14 mm (normal: 2.5±0.7 mm), without any systolo-diastolic variation. Pericardial thickening appeared as a dark low-intensity signal band, demonstrating the fibrocalcific nature of the pericardial contents. Sagittal and coronal cross-sections were particularly well-suited to show the non-uniformity of the pericardial thickening. These results indicate that RNA and MRI are complementary non-invasive methods, and can provide the functional and anatomical information required for the diagnosis of constrictive pericarditis.
    Type of Medium: Electronic Resource
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  • 188
    ISSN: 1619-7089
    Keywords: Brain atlas ; Warping ; Emission tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An elastic computerized brain atlas was developed for the analysis of positron emission tomography/single-photon emission tomography (PET/SPET) data. It consists of a set of digital anatomical contours and a template of regions of interest, schematically describing the brain, derived from a currently used anatomical/functional brain atlas. A warping algorithm, matching equivalent contours, was implemented to elastically fit the atlas to individual brain images. The elastic computerized brain atlas was applied to representative magnetic resonance imaging (MRI)-PET/SPET studies, MRI providing the anatomical information used by the matching procedure. The atlas is suited for clinical use in a nuclear medicine environment.
    Type of Medium: Electronic Resource
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  • 189
    ISSN: 1619-7089
    Keywords: Soft tissue sarcomas ; Thallium-201 ; Magnetic resonance imaging ; Post-therapy changes ; Residual/recurrent tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed a prospective study to evaluate the imaging potential of thallium-201 as compared with other imaging modalities in differentiating residual/re-current tumors from post-therapy changes in patients with musculoskeletal sarcomas.201TI scans, magnetic resonance imaging (17), X-ray computed tomography (6) or contrast angiography (6) studies in 29 patients previously treated for musculoskeletal sarcomas were correlated with either histopathologic findings (26 patients) or 2-year clinical follow-up (three patients). All imaging studies were acquired within 2 weeks. Ratios of201T1 tumor uptake to the contralateral (28 patients) or adjacent region of interest were calculated. When qualitative interpretation was in doubt, only those cases with a ratio of 1.5 or more were considered suggestive of recurrent or residual viable tumor tissue. Residual or recurrent tumor tissue was verified in 21 patients by biopsy. All had true-positive201Tl scans while the other imaging modalities were true-positive in 20 and equivocal in one. In eight patients, there was no evidence of viable tumor tissue as proven by biopsy in five and long-term clinical follow-up in three.201Tl scan was false-positive (ratio 1.5) in one patient and true-negative in seven while the other' imaging modalities had four false-positives. The average201T1 ratios were 3.8±1.1 in the true-positive cases and 1.3±0.3 in the true-negative cases. The percentage sensitivities, specificities, and accuracy for201T1 were 100%, 87.5%, and 96.5% versus 95%, 50%, and 82.7% respectively for other imaging modalities These results indicate that201T1 scintigraphy is more accurate than other imaging modalities in differentiating residual/recurrent musculoskeletal sarcomas from post-therapy changes.
    Type of Medium: Electronic Resource
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  • 190
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 197-209 
    ISSN: 0886-9383
    Keywords: proficiency test ; true value ; homogeneity robust statistic ; standard ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Profficiency tests raise two types of problems: (i) the homogeneity of a sample must be carefully checked before using it as a reference material; (ii) it is necessary to define a conventional reference value (RV) in order to rank participants. Since these topics are poorly addressed in the literature, a reference material was specially prepared in order to propose a procedure for verifying homogeneity and to establish whether the algorithms classically used to compute the conventional true value have an influence on the conclusion of the test.The homogeneity of the sample was not perfect and univariate and multivariate techniques were used to demonstrate some analytes can be suspected as heterogeneous. However, this was considered adequate for introducing the sample in a large proficiency test organized between four laboratory associations which regularly perform such tests. Altogether more than 3000 measurements were collected and eight algorithms were applied to compute the RV on 14 analytes. Thus is was possible to demonstrate that some of these algorithms are better adapted than others. It is also obvious that some analytes are better suited to proficiency testing.It can be concluded from this work that some effort towards standardization would be profitable to check homogeneity or to compute the RV, especially since the economic weight of proficiency testing is becoming even more important with the development of certification accreditation.
    Additional Material: 3 Ill.
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  • 191
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995) 
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 192
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 451-457 
    ISSN: 0886-9383
    Keywords: non-linear regression ; optimization ; robust methods ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several robust regression methods, including a new proposal, are described and their properties discussed. Resistance to various types of outliers and non-normality is demonstrated. The techniques are applied to non-linear regression models from chemical kinetics and calibration. Optimization of the types of objective functions encountered when applying robust regression is considered.
    Additional Material: 5 Ill.
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  • 193
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 471-481 
    ISSN: 0886-9383
    Keywords: batch prediction ; continuum regression ; multivariate calibration ; sequential prediction ; simultaneous prediction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In analytical chemistry a single fitted calibration model is used repeatedly to predict the level of the analyte of interest for the specimens comprising the prediction set. Unlike the calibration (or training) set, which is often limited in size, the prediction set can be very large.In the case of multivariate calibration a number of methods such as PLS and PCR are commonly used to construct the calibration model. The set of instrumental measurements and the reference analyte level are available for each specimen in the calibration set. For specimens in the prediction set, only the instrumental measurements are available, since the problem is to predict the analyte level for these specimens. It is not widely recognized that predictions of the analyte levels for individual specimens can be improved by utilizing seemingly unrelated information from the instrumental measurements associated with the other members of the prediction set. In the case of PCR there exists a very straightforward procedure for doing this. A description of the various sources of prediction errors is provided to explain the ability of PCR to utilize this additional information. The use of PCR in this context is illustrated with both a synthetic and a real example.
    Additional Material: 1 Ill.
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  • 194
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
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  • 195
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 21-29 
    ISSN: 0886-9383
    Keywords: Near-infrared absorbance ; Partial least squares ; Principal component regression ; Root-mean-square error of prediction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of principal component regression (PCR) as a multivariate calibration method has been discussed by a number of authors. In most situations principal components are included in the regression model in sequence based on the variances of the components, and the principal components with small variances are rarely used in regression. As pointed out by some authors, a low variance for a component does not necessarily imply that the corresponding component is unimportant, especially when prediction is of primary interest. In this paper we investigate a different version of PCR, correlation principal component regression (CPCR). In CPCR the importance of principal components in terms of predicting the response variable is used as a basis for the inclusion of principal components in the regression model. Two typical examples arising from calibrating near-infrared (NIR) instruments are discussed for the comparison of the two different versions of PCR along with partial least squares (PLS), a commonly used regression approach in NIR analysis. In both examples the three methods show similar optimal prediction ability, but CPCR performs better than standard PCR and PLS in terms of the number of components needed to achieve the optimal prediction ability. Similar results are also seen in other NIR examples.
    Additional Material: 2 Ill.
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  • 196
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. i 
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 197
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 137-138 
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 198
    ISSN: 0886-9383
    Keywords: pattern recognition ; infrared spectra ; factor analysis ; maximum likelihood method ; entropy of information ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The spectral region from 700 to 3600 cm-1 is subdivided into several wave number intervals. The peaks in each interval are summarized by means of three encoding algorithms. Using a factor model of kcommon factors, the total extractable variacnce (com) of a given set of intervals is calculated and correlated with the redundancy of information in all these intervals. The value of com is verified by analysis of the factor loadings aik (factor pattern). Finally, the information content of some chosen sets of intervals coded by the three selected feature algorithms will be correlated to the probability of information flow through a serial-parallel network. The encoding using only wave numbers was found to be the most effective.
    Additional Material: 9 Ill.
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  • 199
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 211-221 
    ISSN: 0886-9383
    Keywords: diagnostics statistics ; QSAR ; MASCA ; principal component regression ; non-least squares regression ; types of multicollincarity ; flagged observations ; influential points ; high-leverage points ; outliers ; extra-carrier points ; random perturbation ; cluster correalation ; resampling ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The formal application of a Hansch analysis to a series of 3-quinuclidinyl benzylates (QNBs) led to a ‘statistically significant’ QSAR equation. In contrast, the application of the MASCA model has shown that the design matrix is unsuitable for each QSAR analysis: one sample member is an outlier but not a high-leverage or influential point; another one is an influential point, a high-leverage point and an extra-carrier point. The regressors of the design matrix are multicollinear without predictive model power. The result of such flagged observation and this type of multicollinearity is a multiple cluster correlation. The QNB series is a good example for ‘sampling artifacts’ where no practically important but artificial QSARs can be found.
    Additional Material: 3 Ill.
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  • 200
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    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 9 (1995), S. 230-231 
    ISSN: 0886-9383
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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