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  • 1965-1969  (2.089)
  • Life and Medical Sciences  (2.026)
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  • 101
    Digitale Medien
    Digitale Medien
    Masthead (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969) 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290201
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  • 102
    Digitale Medien
    Digitale Medien
    A comparative study of the ring glands from wild type and 1(2)gl mutant Drosophila melanogaster (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 171-199 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Drosophila melanogaster homozygous for the second chromosomal, recessive lethal gene 1(2)gl form puparia much later than wild type (+) and are unable to metamorphose. Implantation of + ring glands accelerates puparium formation by 1(2)gl hosts. The ring gland is a compound structure containing the prothoracic glands (pg), corpus allatum (ca), and corpus cardiacum (cc). An electron microscopic study demonstrates that in both the pg and ca the most common subcellular component is smooth surfaced endoplasmic reticulum (ser). In + flies the amount of ser per pg increases by ten times during the four hour prepupal period. In 1(2)gl flies which have spent two days in the prepupal period the pg looks juvenile and contains only 1% the amount of ser per cell found in the + prepupal pg. The ca cells look alike in both + and 1(2)gl individuals, and the cortical cells of the cc in both contain abundant neurosecretory spheres. We suggest that the + allele of 1(2)gl indirectly influences the synthesis of ser by the pg and that this is the site where dietary cholesterol is transformed to ecdysone.
    Zusätzliches Material: 22 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290204
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  • 103
    Digitale Medien
    Digitale Medien
    Cytochemical and fine structural analysis of oogenesis in the gastropod, Ilyanassa obsoletaThis investigation was supported by a grant (GM 08776) to one of us (EA) from the National Institutes of Health, United States Public Health Service. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 211-247 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: An analysis of differentiating oocytes of the gastropod, Ilyanassa obsoleta, has been made by techniques of light and electron microscopy. Early previtellogenic oocytes are limited by a smooth surfaced oolemma and are associated with each other by maculae adhaerentes. Previtellogenic oocytes are also distinguished by a large nucleus containing randomly dispersed aggregates of chromatin. Within the ooplasm are Golgi complexes, mitochondria and a few cisternae of the rough endoplasmic reticulum. When vitellogenesis begins, the oolemma becomes morphologically specialized by the formation of microvilli. One also notices an increase in the number of organelles and inclusions such as lipid droplets. During vitellogenesis there is a dilation of the saccules of the Golgi complexes and cisternae of the endoplasmic reticulum. Associated with the Golgi complexes are small protein-carbohydrate yolk precursors encompassed by a membrane. These increase in size by fusing with each other. The “mature” yolk body is a membrane-bounded structure with a central striated core and a granular periphery. At maturity a major portion of the ooplasmic constituents such as as mitochondria and lipid droplets occupy the animal region while the bulk of the population of yolk bodies are situated in the vegetal hemisphere.The follicle cells incompletely encompass the developing oocyte. In addition to the regularly occurring organelles, follicle cells are characterized by the presence of large quantities of rough endoplasmic reticulum and Golgi complexes whose saccules are filled with a dense substance. Associated with the Golgi saccules are secretory droplets of varied size.Amongst the differentiating oocytes and follicle cells are Leydig cells. These cells are characterized by a large vacuole containing glycogen. A possible function for the follicle and Leydig cells is discussed.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290206
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  • 104
    Digitale Medien
    Digitale Medien
    A fine structural analysis of the statocyst in Aplysia californicaThis research is partially supported by grant GB-3595 from the National Science Foundation and grant 1-RO1-NB07711-01 from the U.S.P.H.S. The author is a recipient of career development award 5-KO3-GM-31754-02. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 113-131 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Each statocyst in Apylsia californica contains 13 neurons. The statocyst nerve, which connects each statocyst to the cerebral ganglion, contains only the 13 axons of the statocyst neurons. The size of the statocyst, the number of neurons in the statocyst, and the average axonal diameter does not change even though the statocyst nerve lengthens greatly as the animal enlarges. A description of the statoconia and the supporting cells in this organ has been given. This prepazation may be useful for microelectrode studies designed to test whether the gap and cytoplasmic specializations that are used to identify active synapses, are necessary for all types of chemical synaptic transmission.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270107
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  • 105
    Digitale Medien
    Digitale Medien
    Tooth attachment by means of a periodontium in the trigger-fish (Balistidae) (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 1-5 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Tooth attachment in the majority of the bony fish is by ankylosis or fibrous membrane. However, in one group of the osteichthys, the trigger-fish or balistids, tooth attachment is by means of a periodontium composed of a shallow alveolar socket, a periodontal ligament and acellular cementum.Histologically, the balistid periodontal ligament is composed of a dense fibro-cellular connective tissue possessing an abundance of typical fibrocytes, collagen fiber bundles, and oxytalan fibers. The collagen fiber bundles which resemble the principal fiber bundles of the mammalian periodontal ligament are inserted into the bone of the shallow alveolar sockets and are anchored to the teeth by means of a layer of amorphous acellular cementum that covers the radicular dentin. No cementoblasts were found in functional teeth, and epithelial rests are lacking. The mid-central zone of the balistid periodontal ligament is occupied by small blood vessels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270102
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  • 106
    Digitale Medien
    Digitale Medien
    Observations on the origin of two substances produced by the vitellaria in Gorgoderina attenuata (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 431-438 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The vitelline cells in Gorgoderina attenuata produce two qualitatively distinct substances. One substance assumes the form of individual, dense, osmiophilic globules. Many globules are contained in a single vesicle. The other substance is an amorphous mass of medium density that completely fills a vesicle.Observations indicate that the dense, osmiophilic globules develop in association with a system of small, contiguous, ribosome-free vesicles. It is suggested that this system of vesicles constitute a Golgi apparatus for these cells.The amorphous mass substance develops in vesicles which appear to be derived from endoplasmic reticulum. Close association between the amorphous mass vesicle and mitochondria are commonly observed.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270404
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  • 107
    Digitale Medien
    Digitale Medien
    Structure of the apical cells of the testis of the tenebrionid beetles: Tenebrio molitor and Zophobas rugipes (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 409-429 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The developmental cytology of the apical tissue of the testis of Tenebrio molitor and Zophobas rugipes was studied with light and electron microscopy. In the early larvae of both species the tisue was found to be a thickened protrusion of nongerminal cells appearing at the apical end of each testis follicle following gonadal differentiation. The cells persist through pupal and adult stages in both species, becoming more prominent at these stages in Z. rugipes, despite tracheal invasion in both species. In older adults the apical tissue regresses and ultimately distintegrates.Ultrastructurally the apical cells are distinguished from adjacent germinal cells by their (1) small, rounded or oval nuclei, (2) highly convoluted plasma membrane, (3) electron-opaque cytoplasm, (4) profuse concentrically-stacked, granular endoplasmic reticulum, (5) large aggregates of glycogen-like granules, (6) numerous small, tubular mitochondria, (7) well-developed Golgi centers and (8) striking arrays of microtubules. These cells have many cytological features in common with the androgenic gland cells of crustaceans, but not with the steroidogenic cells of vertebrates. Evidence for the formation of protein granules is also lacking. As yet, experimental procedures have not indicated an endocrine function for these cells in tenebrionids. However, their cytology is consistent with secretory activity of some kind.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270403
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  • 108
    Digitale Medien
    Digitale Medien
    The structure of the rectal pads of Periplaneta americana L. With regard to fluid transport (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 475-509 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The rectum of Periplaneta americana L. is lined with cuticle and has six radially arranged cushion-shaped thickenings, the rectal pads, composed of columnar cells. Narrow strips of simple rectal cells lie between the pads. Tall junctional cells form a thin but continuous collar around the pads where they join the rectal cells. The epithelium is surrounded by a layer composed of circular and longitudinal muscles and connective tissue. This layer of muscle and connective tissue is innervated and tracheated, and is separated from the pad surface by a subepithelial sinus. Fluid flowing through the sinus enters the haemolymph through openings in the muscle layer whre large tracheae penetrate. These openings can be sealed by muscle contractions that appress the muscle around the openings against the pad surface. The tracheae pass on into the pads, following basement membrne-lined indentations of the pad surface. Within the pad tracheolar cells send fine branches between the cells. Near the apical and basal surfaces the lateral membranes of pad cells are bridged by septate desmosomes that form a continuous band around the cells. Between apical and basal septate desmosomes is an interconnected labyrinthine system of intercellular spaces. There are three kinds of space, dilations and apical sinuses, both of variable size, and narrow communicating channels about 200 Å wide. The membranes of the latter have mitochondria closely associated with them. Continuity between the system of spaces and the subepithelial sinus is established by the basement membrane-lined invaginations of the basal surface where tracheae penetrate between pad cells. Apical surfaces of the pad cells are highly infolded and are also associated with mitochondria. However, unlike the lateral membranes facing the narrow channels, the apical membranes have a cytoplasmic coating of particles. Both associations of mitochondria with membranes constitute discrete structural entities that are found in many transporting epithelia, and we have termed them “plasmalemma-mitochondrial complexes.” As the rectal pads are organized into systems of spaces that ultimately open in the direction of fluid movement, existing models of solute-coupled water transport can be applied. However, the rectal pads are structurally more complex than fluid-transporting tissues of vertebrates. This complexity may be related to the ability of the rectum to withdraw water from ion-free solutions in the lumen. We present a structural model involving solute recycling to explain the physiological characteristics of rectal reabsorption.
    Zusätzliches Material: 34 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270407
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  • 109
    Digitale Medien
    Digitale Medien
    Masthead (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 128 (1969) 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051280201
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  • 110
    Digitale Medien
    Digitale Medien
    Ultrastructure of the mouse tracheal epitheliumThis work was supported in part by a special grant (374 [C-1]) from the California Division of the American Cancer Society and in part by a United States Public Health Service grant (AP-00356-03). (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 128 (1969), S. 159-169 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The ultrastructure of mouse tracheal epithelium was examined. The three cell types, basal cells, ciliated cells and goblet cells, described for other mammalian trachea were found to be present although goblet cells occurred only rarely. A cell type, termed the nonciliated cell, not described in other mammalian trachea was frequently found in mouse tracheal epithelium. These cells contained abundant smooth and rough endoplasmic reticulum, free ribosomes, a large Golgi complex, and many mitochondria. There were many vesciles containing an electron dense material near the luminal surface of these cells; these cells were positive for PAS. These features suggested a secretory function for the cells. This, along with the scarcity of goblet cells, suggested that the nonciliated cells of mouse tracheal epithelium fulfill the function of the goblet cells found in other mammalian trachea.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051280203
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  • 111
    Digitale Medien
    Digitale Medien
    Fine structural observations on nuclear maturation during spermiogenesis in Hydra littoralisThis work was supported by grants from the National Cancer Institute (TICA-5055) and from the National Institute of Arthritis and Metabolic Diseases (AM-03688), National Institutes of Health, United States Public Health Service. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 128 (1969), S. 229-240 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Cytodifferentiation during spermiogenesis in Hydra littoralis was studied at the fine structural level. Concentration of nuclear material as well as specific orientation of granular and filamentous nuclear elements are apparent in two regions of the early spermatid: where the nuclear envelope is in contact with mitochondrial membranes at one pole of the cell and at an opposite region where the nucleus is closely apposed to the plasma membrane. Ultimately the mass of condensed nuclear material becomes concentrated at the mitochondrial pole of the cell. Additional electron-dense material is extruded from the nucleus into a large vacuole which is in continuity with the nuclear membrane as well as associated with Golgi lamellae and vesicles. Eventually all residual cytoplasm is sloughed, leaving the nucleus, mitochondria, and flagellum. These observations are suggestive of nucleocytoplasmic interactions during development, especially influences of mitochondria and plasma membranes on chromatin condensation.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051280206
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  • 112
    Digitale Medien
    Digitale Medien
    The bulbus cordis and its septa in Sphenodon punctatus (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 369-374 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Two embryos of Sphenodon punctatus, measuring 17.4 mm and 25.2 mm in length, were used in examining the arrangement of the septa and associated vessel pattern in the bulbus cordis. As in other reptiles, two septa subdivide most of the bulbus into three arterial vessels. The aortico-pulmonary septum passes through an angle of about 160° in its descent toward the ventricle. The aortic septum describes an angle of about 150°. Both partitions terminate anterior to the level of the ventricle, leaving an undivided remnant of the bulbus cordis from which the arterial vessels spring. When compared to other reptilian embryos whose bulbi have been studied in detail (i.e., Chrysemys and Aristelliger), Sphenodon shows similarities in the proximaldistal arrangement of the arterial apertures, the mode of descent of the bulbar septa, and the endocardial cushions, which comprise the bulbar septa. The rotation of the septa, however, is substantially different from that observed in the turtle and the lizard so far studied. The aortico-pulmonary and aortic septa in Sphenodon spiral through angles greater than those in Chrysemys and Aristelliger. This pattern in Sphenodon appears to represent a primitive phylogenetic feature in terms of the evolution of the bulbus in reptiles.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290308
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  • 113
    Digitale Medien
    Digitale Medien
    The development of the eye of Rana pipiens at two different temperaturesBased on a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Bryn Mawr College. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 445-471 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The development of the eye in embryos of Rana pipiens raised at two different temperatures was studied in detail from Shumway stage 16 through Shumway stage 25. One clutch of eggs from each of ten different female frogs was divided into two groups, one of which was raised at a temperature of 14°C and the other at 19°C. The 14° to 19° difference falls in the middle of the temperature range for normal development of Rana pipiens as established by Atlas ('35), Moore ('39), and Ryan ('41). Two hundred embryos, one embryo from each of the ten clutches, raised to each of ten stages at 14° or at 19°, were sectioned for microscopic study of the eye region. Descriptions of the morphology and histology of the developing eye are illustrated by photographs and provide a reference to which development of experimental embryos may be compared. A synoptic checklist is provided which specifies the changes occurring at each stage studied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290405
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  • 114
    Digitale Medien
    Digitale Medien
    Masthead (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969) 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270201
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  • 115
    Digitale Medien
    Digitale Medien
    The ultrastructure of smooth cardiac muscle in the clam, Venus mercenaria (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 163-175 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: A fine structural study of the ventricular muscle of Venus mercenaria has revealed that it is an invertebrate smooth muscle. In the relaxed state induced by acetylcholine, both thick (350 Å) and thin (80 Å) myofilaments are observed. These are loosely distributed in bundles in the periphery of the mononucleated myocytes. The central core of the cell contains an ovoid nucleus, α-glycogen rosettes, round mitochondria and numerous smooth surfaced vesicles of the endoplasmic reticulum. After exposure to serotonin, all myofilaments are compacted in the peripheral cytoplasm and become oriented parallel to the longitudinal cellular axis. This produces contraction bands visible in phase contrast microscopy. Because these myofilaments attach to the cell membrane at sites of attachment plaques, contraction of the cell results in the serial evagination or blebbing of the cell surface. The above features are clearly demonstrable in this invertebrate smooth muscle and strongly suggest a sliding filament model as the contractile mechanism in this tissue. Moreover, the cell surface is thought to play an active and major role in that process.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270204
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  • 116
    Digitale Medien
    Digitale Medien
    Morphogenesis of body segments and appendages during the larval stages of a common spiroboloid milliped (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 127 (1969), S. 341-353 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Three-dimensional, histological, and x-ray techniques provide a picture of body segment and limb morphogenesis. Cell multiplication begins in the proliferation region (“meristem”) during the molt from the preceding instar. By four days post-molt, the cells that will form the new segments are well under way in their anterior, lateral, and dorsal migration. It is suggested that after the anlagen for all the new segments are estabilshed, a mitotic wave commences in the most anterior anlagen and moves posteriorly during the remainder of the instar. When cell proliferation is complete, final differentiation of the segments takes place.The process of limb formation is one of cell proliferation and perhaps migration. Each limb develops in a membranous pocket during the instar following the one in which its respective body segment was formed.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051270305
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  • 117
    Digitale Medien
    Digitale Medien
    Genesis of the reproductive system of mosquitoes. I. Female of Aedes stimulans (Walker)Supported by a grant (GM-12612) from the National Institutes of Health followed by another (CC-00335) awarded by the Communicable Disease Center of the U. S. Public Health Service. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 249-280 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The feminine dimorph has unique structures that produce eggs, select salubrious sites for the offspring, store sperm, and void the eggs. This paper provides a time table for development of these parts in Aedes stimulans based on preparations examined at 5-hour intervals when reared at 21°C. All growths of imaginal parts proceeds independent of activities in the larval tissues.Ovaries produce the eggs in terminal follicles of the ovarioles. Besides ovarioles each ovary contains sheaths for the ovarioles, pedicels attaching them to a central canal, the calyx, ovarian sheath and muscles. Ovaries are recognizable in newly hatched larvae as caps of cells on larger masses which become part of the delivery system for eggs. Each ovary grows forward from its attachment first as a column of cells that differentiates into the several tissues by the time the insect enters pupal life. Prior accounts have considered the ovary as the whole mass of cells on each side of the hemocoel of segment 6. Only the most anterior cells recognizably distinct at the end of embryogeny are generative.The delivery system for eggs is composed of the lateral oviducts and median or common oviduct. Primordia from which the former are derived are present from the end of embryogeny and throughout larval life as two distinct parts. Two ovoid masses occur in the hemocoel of segment 6. To each of these is attached a filament extending backward to an attachment ventrally and caudally in segment 7. They are rapidly changed into definitive lateral oviducts late in pupal life. The single primordium for generating the median genital tract appears during instar 3 as a caudal ventral plate of cells in segment 8 between a pair of bilateral buds and invaginates during instar 4 to form (1) the common oviduct from a midventral pouch, (2) three spermathecae from two lateral invaginations and (3) the elaborate vaginal area. The bilateral buds form no parts of the female.The post-vaginal area or atrium with its accessory organs is derived in part from the ventral plate of segment 8 and that of segment 9. The imaginal disc in segment 9 is present at the end of embryogeny as primordial buds and ventral plate and development is delayed until early pupal life when it projects inward to form part of the atrium and pouches once to form the common opening for the duct of the accessory gland and the canal to the bursa copulatrix. The buds of this disc produce no feminine parts.During the second larval instar lateral primordia appear as a pair of shields in the anal segment. They develop slowly until pupation when they extend caudally as two flaps called “cerci” in culicid literature and this paper.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290302
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  • 118
    Digitale Medien
    Digitale Medien
    Studies on the nature and localization of acid phosphatase in normal and lens-regenerating urodele eyes. II. Biochemical assayThis investigation was supported in part by Public Health Service Research Grant 1R01-NB-07813-01 from the National Institute of Neurological Diseases, and in part by Basic Improvement Grant 1T02-CH-1017-01 from the National Institutes of Health. (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 359-367 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Biochemical assay of acid phosphatase in normal and lens-regenerating eyes of the urodele Diemictylus viridescens, using p-nitrophenyl phosphate as substrate, demonstrates both soluble and lysosomal fractions of the enzyme. While the specific activity of the soluble fraction remains unchanged during lens regeneration, the lysosomal fraction shows four distinct rises in specific activity during the thirty-day regeneration period studied. These peak activities on the second, eighth, fifteenth, and twenty-second days post-lentectomy apparently correspond to lysosomal activity in the processes of wound healing, iris depigmentation, and lens differentiation which occur during urodele lens regeneration. On the basis of biochemical and histochemical studies as well as observations of morphological changes in the urodele eye as lens regeneration proceeds, it is postulated that there is a significant correlation between these morphological changes and the level and localization of the lysosomal acid hydrolases in the tissues in which the changes occur.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290307
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  • 119
    Digitale Medien
    Digitale Medien
    Gustatory sense organs in the food canal of aphids (1969)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 129 (1969), S. 473-491 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: A sensory structure in the anterior region of the food canal of two species of aphid has been examined by light and electron microscopy. The dorsal wall is innervated by a total of 60 neurones which terminate, in groups, at 14 porous papillae on the cuticle. Paired papillae have also been detected in the ventral wall of this region. The fine structure of individual neurones and their grouping around papillae indicates a chemosensory function.The examination of moulting aphids shows that the distal portions of dendrites are shed with the exuviae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051290406
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  • 120
    Digitale Medien
    Digitale Medien
    Wirkung eines Proteinaseninhibitors auf das Tourniquet-Syndrom der Ratte (1969)
    Springer
    Clinical and experimental medicine 151 (1969), S. 55-63 
    Details
    ISSN: 1591-9528
    Schlagwort(e): Postischemic edema ; Protease inhibitor ; Trasylol ; Diminishing effect on edema ; Rat ; Postischämisches Ödem ; Proteinaseninhibitor ; Trasylol ; Ratte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Intravenöse Trasylolgabe kann die Entwicklung eines postischämischen Ödems in proportionaler Dosisabhängigkeit zwischen 10000 und 35000 KIE pro Kilogramm Körpergewicht hemmen. Die intensivste, gegenüber einer Dosis von 35000 KIE//kg KG aber nicht viel stärkere Hemmwirkung, wird mit 50000 KIE/kg KG bei intravenöser Injektion kurz vor Tourniquet-Lösen erreicht. Gaben bis zu 2 1/2 Stdvor und 1 Stdnach Lösen des Tourniquets zeigen ebenfalls noch einen gewissen Effekt. Eine deutliche Wirkung ist auch dann zu erzielen, wenn Trasylol vor Abschnüren der Extremität gegeben wird. Dabei ist der Wirkungsmechanismus nicht eindeutig. In Frage kommt, daß die Entstehung gefäßaktiver Peptide verhindert wird oder daß Trasylol direkt permeabilitätsmindernd auf die Gefäße wirkt.
    Notizen: Summary Intravenous injection of Trasylol can stop the development of postischemic edema in a proportional dose response relationship between 10000 and 35000 KIE per kg body weight. The most intensive effect was seen with 50000 KIE per kg injected just prior to the release of the tourniquet, but this effect was not much stronger than with 35000 KIE. An effect could still be demonstrated when Trasylol was given until 2 1/2 h prior to or 1 h after tourniquet release. A marked effect could be obtained even if Trasylol was given prior to tourniquet application. So far the mode of action is not clear. It might be possible, that the development of vasoactive peptides is hindered or that Trasylol has a direct diminishing effect on the permeability of the vessels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02045114
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  • 121
    Digitale Medien
    Digitale Medien
    Kolloidale Hexacyanoferrate(II) als Antidote bei der Thallium-Intoxikation (1969)
    Springer
    Clinical and experimental medicine 151 (1969), S. 89-92 
    Details
    ISSN: 1591-9528
    Schlagwort(e): Hexacyanoferrate(II) ; Thallium ; Rat ; Hexacyanoferrat(II) ; Thallium ; Ratte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die orale Verabfolgung der kolloidalen Fe(III)-, Co(II)- und Ni(II)-Hexacyanoferrate(II) bewirkt eine starke Herabsetzung der Retention von oral oder intravenös verabreichtem Thallium(I) durch die Organe der Ratte. Die Effektivität ist höher als die des sogenannten unlöslichen Berliner Blau.
    Notizen: Summary Oral administration of colloidal Fe(III)-, Co(II)- and Ni(II)-hexaoyanoferrates(II) leads to a markedly diminished retention of orally or intravenously administered thallium(I) by the organs of the rat. The efficacy surpasses that of the so-called insoluble Prussian Blue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02045117
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  • 122
    Digitale Medien
    Digitale Medien
    Vergleich zwischen der Stickstoffbilanzierung beim Menschen und bei der Laboratoriumsratte (1969)
    Springer
    Clinical and experimental medicine 150 (1969), S. 70-75 
    Details
    ISSN: 1591-9528
    Schlagwort(e): Nitrogen balance ; Man ; Rat ; Stickstoffbilanz ; Mensch ; Ratte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Stoffwechselbilanzversuche unter dem Kriterium des minimalen Stickstoffumsatzes bei Bilanzausgleich werden am Menschen wie an der Laboratoriumsratte mit der gleichen analytischen Genauigkeit ausgeführt. Versuche an Ratten haben — im Gegensatz zu früher ermittelten Resultaten an Menschen — ergeben: 1. Der Ersatz von Eiprotein-N durch Ammonium-N führt in jedem Mischungsverhältnis zu einer Erhöhung des Stickstoffumsatzes. 2. Methioninzulagen zu Ei/NH4 +-Gemischen bleiben ohne Einfluß auf die Stickstoffumsatzgröße. 3. Eine allgemeine Möglichkeit zur Übertragung von Ergebnissen der Rattenversuche auf den Bedarf des Menschen an Stickstoffträgern besteht für die Bilanzmethode nicht.
    Notizen: Summary Metabolism trials under conditions of minimum nitrogen input and nitrogen equilibrium yield the same analytical accuracy (reproducibility of results within a standard deviation of ±1.5%) with men and with rats. In contrast to results with men published formerly, experiments with rats show the following: 1. Replacement of egg protein by non-essential nitrogen (diammoniumcitrate) in any proportions leads to increased nitrogen requirements. 2. Addition of methionine to mixtures of egg protein and ammonia is of no influence on the dimension of nitrogen requirements. 3. A possibility for deducing men's nitrogen requirements from minimum balance results with rats (or vice versa) thus apparently does not exist.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02045840
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  • 123
    Digitale Medien
    Digitale Medien
    Histochemical observation on phosphatase activities of degenerating and regenerating taste buds (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 31-38 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Using rat's circumvallate papillae, ATPase, alk. Pase and acid Pase of taste buds were observed after the transection of the glossopharyngeal nerve.The taste buds began to disappear after the nerve was cut and were completely lost after ten days. Following the regeneration of the glossopharyngeal nerve, taste buds reappeared from the bottom of the gutters of circumvallate papillae about 25 days after the operation.ATPase was strongly present on the cell membrane of taste bud cells as far as they existed during degeneration and regeneration. Alk. Pase, which is normally localized on the superficial layers of the epithelium overlying the gutters of circumvallate papilla, gradually diminished as the taste buds degenerated and reappeared as the taste buds regenerated; that is, the activity began to diminish three days after the operation, became feeble after ten days and reappeared after 25 days. It is concluded that taste bud cells secrete alk. Pase in the gutters of circumvallate papillae. Acid Pase activity, usually found in the supranuclear portion of taste bud cells, was intensely reactive during degeneration but did not reappear at the early stage of regeneration of taste bud cells.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630104
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  • 124
    Digitale Medien
    Digitale Medien
    Endosteal deposition of bone at the midshaft of the second metacarpals of adolescent femalesSupported in part by U.S.P.H.S. grants 5 F3 HD-31,208-02; HD DE 00993; DE 00087; and 5 T1 DE 109. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 67-70 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The endosteal and periosteal diameters of the second metacarpal were measured at the midshaft on radiographs of 62 normal girls at 11.0 ± 0.5 years (pre-menarche) and again at 16.0 × 0.5 (post-menarche). There was an average increase in the periosteal diameter of 10% and an average decrease in the endosteal diameter of 16%, both changes significant at p 〈 0.01. Individual variability was greater for the endosteal than the periosteal surface changes (p 〈 0.01).
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630108
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  • 125
    Digitale Medien
    Digitale Medien
    Normal development of the lateral motor column in the brachial cord in Rana pipiensThis investigation was supported in part by research grant AM02202 from the National Institute of Arthritis and Metabolic Diseases to Dr. Jerry J. Kollros. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 111-119 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Counts of differentiating motor cells over the length of the brachial lateral motor column (LMC) indicate that a large decrease in cell number takes place during the larval period. During the same period an increase in nuclear size of the motor cells occurs with a maximum size attained just following forelimb emergence. Comparison between development of the LMC at the brachial and lumbo-sacral levels indicates a slight lag in brachial LMC development. Cell number remains greater in the brachial LMC than in the lumbo-sacral LMC, but nuclear size is consistently less in the brachial column. Probably no significant change in cell number occurs after metamorphosis, though there is an increase in cell size.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630113
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  • 126
    Digitale Medien
    Digitale Medien
    American Association of Anatomists. Eighty-second annual session; Boston University School Of Medicine, Harvard Medical School, University of Massachusetts School of Medicine, Tufts University School Of Medicine, April 1, 2, 3, 4, 1969. Constitution (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 349-352 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630204
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  • 127
    Digitale Medien
    Digitale Medien
    Inhibition of limb regeneration in the axolotl after treatment of the skin with actinomycin DSupported in part by NIH GRS grant FR-05383-06. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 389-401 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In this experiment actinomycin D was used to explore the action of the wound epidermis on underlying tissues during limb regeneration. In axolotl forelimbs the skin was removed from the elbow to the shoulder. Skin from the right limbs was soaked for three hours in actinomycin D (5.0 or 10.0 μg/ml 0.6% NaCl). For controls, skin from left limbs was soaked in 0.6% NaCl for the same period of time. Each piece of skin was orthotopically replanted, and both limbs were amputated through the treated skin, proximal to the elbow. After an initial healing period, the control limbs regenerated normally. Except for a slightly paler color, limbs bearing actinomycin-treated skin were indistinguishable from the controls, both grossly and histologically, during the first week following amputation. While the control limbs formed early blastemas, no grossly visible evidence of regeneration was apparent in the experimental limbs, but histologically some dedifferentiation was occurring. Normally three to four digits were seen in the control regenerates before blastemas appeared on the experimental limbs. By 35-40 days blastemas had appeared on most experimental limbs. These developed very rapidly, and within a short time many of them had attained levels of development close to the controls. Actinomycin D temporarily suppresses formation of the apical epidermal cap and the subsequent aggregation of dedifferentiated cells into a blastema. When the effect wears off, an apical cap forms and the dedifferentiated cells quickly organize into a blastema and begin to differentiate.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630304
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  • 128
    Digitale Medien
    Digitale Medien
    Luteotropic complex of the mouse (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 373-387 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Pregnant mice were hypophysectomized on day 6 and injected subcutaneously with various hormones from days 6 to 9 to establish the minimal requirements for the maintenance of functional corpora lutea. Luteal activity was assessed by the maintenance of pregnancy, weight of embryonic swellings, mean diameter and morphology of corpora lutea, and vaginal histology.Treatment with 2 mg progesterone maintained pregnancy but not corpora lutea in three of five animals. However, the embryonic swellings were significantly (P 〈 0.0005) smaller than those of pregnant control animals. Pregnancy was maintained in all animals when progesterone was combined with 1 μg of estrone. The weights of embryonic swellings and the degree of vaginal mucification in the combined steroid group were similar to those of intact control animals.Treatment with either ovine prolactin, bovine LH, ovine FSH or estrone failed to maintain corpora lutea or pregnancy. Combined injection of prolactin with LH or estrone did not maintain pregnancy or corpora lutea. On the other hand, treatment with 500 μg of prolactin and 200 μg of FSH maintained pregnancy in 12 of 14 animals. All of the aforementioned parameters of luteal activity were comparable to values in intact, control animals.The data indicate that luteal function in the mouse during the early post-implantation period requires a luteotropic complex rather than a single hormone. Prolactin and FSH constitute the minimal luteotropic complex in the pregnant mouse. The luteotropic activity of FSH was not due to its contamination with LH and the effect of FSH was apparently not mediated through estrogen secretion, since pregnancy was not maintained by prolactin and estrone.
    Zusätzliches Material: 5 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630303
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  • 129
    Digitale Medien
    Digitale Medien
    The ultrastructure of the placental labyrinth in the kangaroo rat, DipodomysThis investigation was supported in part by grant 5 RO1 HD02613, National Institute of Child Health and Human Development, and by funds from the Graduate School and Desert Research Institute, University of Nevada. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 543-554 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Representative pieces of labyrinth of near-term chorioallantoic placentas from three species of Dipodomys and one species of Microdipodops were fixed in glutaraldehyde and osmium tetroxide and examined with the electron microscope. The barrier separating the fetal and maternal blood streams in the labyrinth was found to consist of (1) the fetal endothelium and its associated basal lamina (basement membrane), (2) a single layer of trophoblast which is cellular rather than syncytial, and (3) the maternal endothelium and its associated basal lamina. Thus the chorioallantoic placenta appears to be of the endotheliochorial type in these rodents rather than hemochorial or hemoendothelial as previously suggested.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630406
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  • 130
    Digitale Medien
    Digitale Medien
    Distribution and weights of various cell types in the rat stomach (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 555-561 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: A line sampling method was used to determine the relative volumes of various cell types in the mucosa of the body of the rat stomach. The technique was simple to perform, reproducible and independent of many variables inherent in previous cell counting techniques. Weights of the various cell types were calculated from stomach weights, relative mucosal volumes and cell concentrations in the mucosa. In the five animals studied, gastric body mucosa average 40% of the stomach weight and 1.8 gm per kg of rat. Parietal cells averaged 40% of the gastric body mucosa weight and 0.7 gm per kg of rat. There was no significant variation in parietal cell concentration throughout the gastric body mucosa of the rat. Chief cells averaged 18% of the gastric body mucosa and 0.3 gm per kg of rat. Up to three-fold variations in chief cell concentration occurred with highest concentrations near the greater curvature and in proximal areas of the body mucosa. Mucous surface cells, mucous neck cells, and connective tissue made up 22, 9, and 7% of the body mucosa respectively and showed only minor varitions in concentration.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630407
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  • 131
    Digitale Medien
    Digitale Medien
    Cholesterol changes in developing testicular interstitial cells of the mouse: Histochemical and biochemical study (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 595-601 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In combination with biochemical determination of cholesterol in testes, cholesterol was studied histochemically in the testicular interstitial cells of dd strain mice from 5 to 63 days.Cholesterol is found in interstitial cells at five days and cholesterol positive interstitial cells increase significantly from 7% at 5 days to 47% at 21 days (17% at 7 days, 21% at 10 days and 31% at 14 days) and thereafter gradually to 58% at 63 days (50% at 28 days, 54% at 35 days, 56% at 42 days, 58% at 49 days and 57% at 56 days).The cholesterol concentration of testes (μg of cholesterol per mg testicular weight) remains at low values before 42 days (1.33 at 5 days, 2.12 at 7 days, 1.89 at 10 days, 2.18 at 14 days, 2.16 at 21 days, 1.63 at 28 days and 2.09 at 35 days) but it increases rapidly at days 42-49 (2.21 at 42 days and 5.16 at 49 days) and then it is almost unchanged (5.47 at 56 days and 5.18 at 63 days).From these results it is suggested that (1) at five days testicular steroid could be elaborated and (2) the capacity of interstitial cells to produce testicular steroid elevates actively from 42 to 49 days.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630411
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  • 132
    Digitale Medien
    Digitale Medien
    Early development of thymic lymphocytes in mice, studied by light and electron microscopy (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 47-65 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Thymic rudiments from mouse embryos varying in gestational from 10-13 days were examined by light and electron microscopy in an effort to learn the origin of thymic lymphocytes. Lymphocytes were recognized and distinguished from mesenchymal cells and thymic epithelial cells by their round shape, larger nucleoli, and high concentration of cytoplasmic ribosomes and dearth of endoplasmic reticulum. No lymphocytes could be found at the earliest stage of development of the third pharyngeal pouch  -  at approximately ten days' gestational age. They first appeared in the mesenchyme surrounding the third pouch at a later stage, (approximately 11 days' gestation), but in most cases did not appear in the thymic epithelium until the parathyroid and thymus began to differentiate at approximately 12 days' gestation. No cells were seen that appeared to be transitional between lymphocytes and epithelial or mesenchymal cells and it was concluded that these observations support the hypothesis that lymphocytes first reach the thymic parenchyma by immigration from the surrounding mesenchyme. Most of the lymphoctyes found in the region of the thymus at these stages of development were large lymphocytes. The origin of these early lymphocytes remains unknown.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640104
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  • 133
    Digitale Medien
    Digitale Medien
    The trigemincd nerve root with special reference to the central-peripheral transition zone: An electron microscopic study in the macaqueSupported in part by USPHS grants NB-3604, NB 5685 and NB 6594.The authors wish to express their appreciation for the excellent technical assistance of Mrs. O. Fiorello and Mrs. M. Severin. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 113-125 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The entry zone of trigeminal sensory root fibers displays a “glial dome” covered by a basal lamina. This zone constitutes the “fibrous cone” of gross descriptions of the root and demarcates a sharp transition from peripheral to central nervous system. The dome consists of closely interwoven astrocyte processes, and appears to be identical to the subpial astrocyte meshwork elsewhere in the central nervous system. In the peripheral portion of the root, axons are surrounded by Schwann cells; those associated with myelin sheaths display distinctive laminar inclusions and pinocytotic vesicles lacking in Schwann cells which surround unmyelinated axons. In the peripheral region, separate and distinct endoneurial and perineurial layers of collagen could not always be identified. In the central part of the root, Schwann cells, fibroblasts, and collagen are absent and from the point of transition, the axons are principally surrounded by astrocytes. Oligodendrocytes are relatively rare in the transitional zone. The axonal transition from central to peripheral, occurs at nodes of Ranvier where the basal lamina of the dome is continuous with the basal lamina of the Schwann cell of the last peripheral internode. Some “islands” of glial tissue are interspersed in the root and ganglion but it was not established if these are completely discontinuous with the central “glial dome.” No ganglion cells have been found in such “islands,” nor in the glial dome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640108
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  • 134
    Digitale Medien
    Digitale Medien
    Differentiation of growth hormone- and prolactin-containing acidophils with peroxidase-labeled antibodySupported in part by USPHS research grants HD 03159-01A1 and HD 02193, and a grant from the University of Michigan Horace H. Rackham School of Graduate Studies. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 163-171 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In order to verify the concept that growth hormone and prolactin are contained in two different populations of acidophils, sections of Bouin-fixed rat hypophyses were stained immunochemically. For this purpose the histochemical demonstration of peroxidase was utilized after sequential application to the tissue section of rabbit antiserum to human growth hormone (or antiserum to rat prolactin) followed by application of peroxidase-labeled sheep antiserum to rabbit gamma-globulin. It was found that growth hormone cells and prolactin cells, when revealed immunochemically, corresponded structurally to cell types that could be differentiated with reasonable certainty in sections stained with the Masson trichrome procedure. When delineated immunochemically, growth hormone cells were larger and more densely arranged in the adult male than in the intact female; they exhibited little change in the female after ovariectomy. In contrast, prolactin cells were large and frequent in the female hypophysis but were small and less frequent in the male and in the female after ovariectomy. By double-staining, growth hormone and prolactin cells were differentiated in the same section. It was concluded that (a) growth hormone and prolactin are contained in, and presumably secreted by, two different populations of acidophils; and (b) the Masson procedure permits a reasonably accurate differentiation of the two cell types.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640204
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  • 135
    Digitale Medien
    Digitale Medien
    The evolution and development of the dens of the mammalian axis (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 173-184 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Certain members of the extinct reptilian group from which mammals evolved possessed both a dens and an atlas body. Available paleontologic evidence supports the conclusion that the dens evolved as an addition to the atlas body. There-fore, the dens is not homologous with the atlas body as is generally claimed on the basis of supposed developmental evidence. The atlas body is large in the most primitive of living mammals, the monotremes, which also possess a dens of typical mammalian proportions. In metatherian and most eutherian mammals, both a dens and an atlas body remnant of variable size are present. The development of the dens in the Virginia opossum, Didelphis marsupialis, confirms the fact that the dens arises from, but does not replace, the atlas body anlage. The dens evolved as a functional replacement of the atlanto-axial articular processes which were lost when the mammalian atlanto-axial joint became specialized for rotational movement.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640205
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  • 136
    Digitale Medien
    Digitale Medien
    Cytoplasmic fine structure during hormonally controlled differentiation in vaginal epitheliumThis investigation was supported by a USPHS research giant (HD 01314) from the Institute of Child Health and Human Development and a training grant (GM 00459) from NIH. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 205-217 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Cells of the vaginal epithelium of ovariectomized mice undergo differentiation in response to estrogen or progesterone injection. Estrogen causes an increase in number of cytoplasmic filaments in the basal and newly formed spinous layer and mucification of surface cells already present. The cells derived from the basal layer under estrogen influence later form a keratinized epithelium. Progesterone causes heightening and mucification of surface cells and invasion of leucocytes into the epithelium without mucification or keratinization of other cells. When estrogen is followed two days later by progesterone, spinous and more superficial cells are lost and replaced my mucous cells derived from the basal layer. Although the fine structure of basal and spinous cell cytoplasm looks identical, the spinous cells do not form mucous cells under progesterone influence. The reverse sequence of progesterone followed by estrogen produces a low epithelium which is then replaced by a keratinized epithelium. The surface mucous cells present during progesterone influence do not keratinize, however. Thus, fine structural features of basal cells typical for the influence of a given hormone do not limit or characterize the potential of daughter cells derived from that layer. Conversely, when hormones are used in sequence, cells which leave the basal layer under the influence of one hormone do not acquire the fine structural features characteristically produced by the second hormone used, even though basal cells are readily altered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640207
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  • 137
    Digitale Medien
    Digitale Medien
    Nerve endings in skin of the australian black snake (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 259-265 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Histological preparations from skin of the Australian black snake, Pseudechis Porthyriacus have revealed myelinated nerve fibers terminating in several structures. The commonest of these, the simple “End Button,” was seen in the epidermis from all regions of the body. An end organ, the “touch corpuscle” occurred in the epidermis of the upper and lower lip, while in the dermis of the upper and lower jaw an encapsulated structure, the “club corpuscle” was frequently encountered. These more complex structures could not be revealed in skin of the trunk where only “end buttons” were seen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640302
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  • 138
    Digitale Medien
    Digitale Medien
    The phrenic nerve: Its terminal divisions and supply to the crura of the diaphragmAided by grant 5 T02 CH 1105105, Health, Education and Welfare. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 283-289 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: A study of the crura of the diaphragm and their innervation from the phrenic nerve was made in 22 fresh specimens and four embalmed specimens. The arrangement of the musculature was found to be essentially the same as that described by Low in 1907. The portions of the crural musculature passing to the right and left of the esophagus did not decussate anterior to the esophagus as these fibers insert into the central tendon. The right and left phrenic nerves divided into three to five divisions at the pericardiodiaphragmatic angle. Most commonly, these divisions are: anterior, posterior and lateral. If there are more than three divisions involved, there is usually a medial division present and/or a subdivision of one of the other divisions. It is the posterior division or its posteromedial branch which contributes to the innervation of the crura. None of the other divisions contributes to the innervation of the crura. Secondary branches of either the posterior division or the posteromedial branch do not cross to the contralateral side.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640304
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  • 139
    Digitale Medien
    Digitale Medien
    Spermatogenesis in the rabbit following ligation of the epididymidis at different levelsThis work was supported in part by Public Health Service Research grant HD 03471 from The National Institute of Child Health, and Human. Development. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 339-347 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Ligatures were placed unilaterally on the ductus deferens (experiment 1), on the ductus deferens and the middle of the corpus epididymidis (experiment 2) and on the ductus deferens, corpus epididymidis and ductuli efferentes (experiment 3) in 39 rabbits. The untreated contralateral side served as a control. Vasectomy alone appeared to have no effect upon the testes, or upon spermatozoa accumulated during a period of 12 weeks proximal to the ligature. In experiment 2 severe disruption of spermatogenesis occurred. Diameter of the seminiferous tubules decreased, testes atrophied, and the stages of the seminiferous epithelium were abnormal and often not classifiable. Some regeneration was observed after 12 weeks.In experiment 3 there was only a moderate and more transient disturbance of spermatogenesis. This occurred in spite of an accumulation of fluid in the testis due to the ligature on the ductuli efferentes, which prevented testicular effluent from reaching the caput epididymidis. These results suggest that when testicular effluent is allowed to reach the caput, but nonresorbed residues are prevented from further transport (experiment 2), a feedback to the testis occurs which is more harmful than that produced by preventing tubular contents from leaving the testes.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640309
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  • 140
    Digitale Medien
    Digitale Medien
    The purkinje cell cilium (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 127-139 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus. Rootlets with periodic cross-striations (interperiod distance of 525 ÅR) are attached to the basal body. The size and characteristics of the Purkinje cell cilium and its constituent parts compare with similar structures in the cilia of other cell types of the cerebellar cortex. Whether all or only some of the Purkinje cells have a cilium has not yet been determined. Possible functional roles of these organoids are considered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650202
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  • 141
    Digitale Medien
    Digitale Medien
    Origin of amphibian premelanosomes and their relation to microtubules (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 185-195 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In amphibian melanophores, premelanosomes appear to be formed in fenestrated cisternae of the Golgi complex. The premelanosomes may develop within the cisternae or vesicles containing melanoprotein may bud from the cisternae to form premelanosomes. Some micrographs also demonstrate a close association between microtubules and either premelanosomes or melanosomes. The microtubules themselves may originate from electron dense particles in the centrosphere region of the cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650205
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  • 142
    Digitale Medien
    Digitale Medien
    Osmium binding to the surface coat of intestinal microvilli in the cat under various conditionsSupported by Grant AM 09432-04, National Institutes of Health, U.S.P.H.S.A report of this study was presented at the 8th Annual Meeting of the American Society for Cell Biology (Pratt, ′68) (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 197-209 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The appearance of the carbohydrate-rich surface coat covering the the intestinal epithelium of the cat varies with different methods of fixation for electron microscopy. A fibrillar surface coat covers the external surfaces of the microvilli after fixation in glutaraldehyde and postfixation in phosphate-buffered OsO4; its density is enhanced by heavy metal staining. In tissue fixed in glutaraldehyde alone or followed by dehydration in acetone and postfixation in OsO4 in carbon tetrachloride, a structureless zone less dense than Epon occurs where the surface coat is usually visualized; heavy metal staining does not impart density to the zone. The absence of structure and low density of the zone are not due to extraction of the surface coat by dehydrating agents or by carbon tetrachloride. The data suggest that osmium binds to the surface coat from phosphate buffer, but not from carbon tetrachloride. Also OsO4 in phosphate buffer, but not OsO4 in carbon tetrachloride, facilitates heavy metal staining of the surface coat. Acidic carbohydrates appear to be important for the differential binding of osmium observed in this study. The need for caution in interpreting low density areas of electron micrographs as extracted structures and high density areas as “osmiophilic” structures is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650206
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  • 143
    Digitale Medien
    Digitale Medien
    Development of the amphibian pineal organ; cell proliferation and migrationThis investigation was supported by a research grant (GB-6910) from the National Science Foundation. The authors are indebted to Dr. N. B. Everett and Mrs. Ruth Tyler for their critical review of the manuscript, to Mrs. Sandra Kunz and Mrs. Nancy Gross for their able technical assistance and to Mrs. Doris Ringer for secretarial help. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 211-227 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The development of the pineal organ in the newt Taricha torosa has been studied utilizing cell counts and radioautography following single injections of tritiated thymidine. Embryos injected two weeks before hatching (series I) demonstrated a grain distribution pattern in the pineal organ and its underlying proliferation zone characteristic of continuous availability of isotope. Larvae injected at hatching (series II) or two weeks after hatching (series III) displayed the expected pulse label pattern for these same regions. With the possible exception of some mitosis insituin the youngest organs, pineal cells originate from a mitotically active cell population which comprises the pineal proliferation zone. After cell division some daughter cells migrate into the pineal organ, moving into the posterior part of the organ during the prehatching period, while from hatching onward the predominant migration is into the anterior part of the organ. Both the pineal photoreceptors and supportive cells arise in this manner with labeled cells of both types found in all three series, but in decreasing numbers from the youngest to the oldest series.Cell counts disclose an approximate ten-fold increase in the number of cells within the pineal organ from embryonic to adult stages, but the rate of cell addition slows with increasing age. Both photoreceptors and supportive cells show this increase in number with the photoreceptor population being maintained at a constant 14%-18% of the total pineal population over this entire five-year period.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650207
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  • 144
    Digitale Medien
    Digitale Medien
    Electron microscopic observations on myoid cells of the frog's thymusDedicated to Professor Neubert on the occasion of his 70th birthday. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 329-341 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Myoid cells of the thymus of hibernating frogs were examined by electron microscopy. This cell type is represented by immature, fully-developed and degenerating cell forms. The immature forms are mainly located at the surface, whereas the developed ones are found in the inside of the thymus. A peculiar type of immature cell containing no thick filaments, but possessing a rich sarcoplasmic reticulum among the thin filaments is described. The developed myoid cells have a myofibrillar apparatus showing regular cross-striations. The myofibrils are arranged in concentric layers around the nucleus. The proposed role and origin of myoid cells and their probable connection with myasthenia gravis are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650302
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  • 145
    Digitale Medien
    Digitale Medien
    The clefts of schmidt-lantermann: A quantitative electron microscopic study of their structure in developing and adult sciatic nerves of the ratSupported by Public Health grants NB 06239 and NB 3021 from the National Institute of Neurological Diseases and Blindness. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 89-101 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: A quantitative electron microscopic study of the clefts of Schmidt-Lantermann in fibers of the sciatic nerves of young and adult rats showed that the clefts are formed by two conical “male” and “female” portions of the sheath. The circumference of the female cone is approximately 15% larger than the male cone. The surfaces of the cleft transect the sheath at angle of approximately 9°. The present data indicate, also, that both the configuration of the conical portions of the sheath and their position relative to each other may change prior to fixation. Calculations indicate that each cleft permits a change in axoplasmic volume by 22%, and a change in fiber length by 9% of the fiber diameter.Clefts were not observed in nerves of rats before the twelfth day of age nor in sheaths of fibers composed of less than 20 lamellae. Newly formed clefts were wider than adult clefts. Transitional forms suggest that clefts may develop from fibers with redundant loops of myelin sheath. Radioautographic data on the incorporation of H3-leucine in nerve fibers did not indicate transport of significant amounts of this isotope into the clefts.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650110
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  • 146
    Digitale Medien
    Digitale Medien
    The fine structure and development of the neck region of the mammalian spermatozoonResearch supported by grants GM-06927 and HD 02344 from the Institute of Child Health and Human Development, National Institutes of Health, United States Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 153-183 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The cross-striated connecting-piece in the neck region of the mammalian spermatozoon develops from material that seems to arise between the triplets in the wall of both proximal and distal centrioles. The precursor material extends radially from the centrioles and polymerizes around them to form the connecting piece. This is not composed of “segments” or “lamellae” as usually described but is a cross-striated fibrous protein with a major period of 665 A and a complex pattern of intraperiod bands. It is considered to be homologous with the striated rootlets of cilia.During differentiation of this region, the proximal centriole develops at one end, a cylindrical prolongation which is similar in its structure but not identical with the centriole proper. This centriolar adjunct is a transient structure. The proximal centriole persists in the mature spermatozoon, but the distal centriole disintegrates during formation of the connecting-piece.The outer dense fibers of the flagellum and the cross-striated columns of the connecting piece are distinct components which arise separately and secondarily become continuous. The dense fibers originate as ridge-like radial outgrowths from the wall of the corresponding doublets in the axonemal complex. As they enlarge they separate from the doublets throughout most of their length but they remain continuous with them at their distal ends.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650204
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  • 147
    Digitale Medien
    Digitale Medien
    The fine structure of endothelial cells of toad arteries (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 229-235 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The vascular endothelia of the aortic, iliac and kidney arteries of the toad Bufo arenarumH. and the frog Leptodactylus chaquensis were studied with the electron microscope. The shape and size of the endothelial cells appear to depend upon whether the internal elastic membrane is stretched or contracted. These cells present the following characteristics: (1) an elongated and folded nucleus, (2) large bundles of oriented filaments, (3) acid phosphatase-positive micropinocytotic vesicles, (4) small, dense, spherical granules surrounded by a single membrane. These cytoplasmic granules, also studied by histochemical techniques, are of unknown nature and function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650208
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  • 148
    Digitale Medien
    Digitale Medien
    Proceedings of the American Association of Anatomists eighty-second meeting (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 257-328 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650210
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  • 149
    Digitale Medien
    Digitale Medien
    The fine structure of the extracellular matrix during epithelio-mesenchymal interactions in the rabbit embryonic incisorThis work was supported by grant DE 01177-09 and DE 02768-01 awarded by the National Institute for Dental Research, U.S. Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 237-255 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The fine structure of the extracellular matrix during epithelio-mesenchymal interactions in the rabbit embryonic tooth germ is described using light and electron microscopy. Observations are restricted to the labial cervical loop region at the bell stage of development in maxillary and mandibular incisor tooth germs. Histochemical methods demonstrate a PAS-positive basement membrane between outer enamel epithelial cells and adjacent undifferentiated mesenchymal cells. The metachromatic region circumscribes the dental papilla region, becoming more intense and wider in association with cells illustrative of more advanced stages of differentiation. Ultrastructural observations of the basal lamina associated with outer enamel epithelial cells, cervical proliferating epithelial and mesenchymal cells, and with inner enamel epithelial cells and pre-odontoblasts are reported. The characteristic mesenchymal filopodia appeared in close proximity to the basal lamina. Microfibrils are seen as depositions on the basal lamina and in association with filopodia. The concentration of intercellular microfibrils is increased when in association with epithelia showing advanced differentiation. Collagen fibrils are frequently noted in peripheral association with mesenchymal cells but not adherent to the basal lamina. Numerous homotypic and heterotypic cell junctions are seen. An understanding of intercellular communication between heterotypic cells may be enhanced by postulating a dual developmental origin for the microfibrils associated with the basal lamina. The under surface of the basal lamina facing the extended mesenchymal filopodia appears to be a significant factor during epithelio-mesenchymal interactions, subsequent extracellular matrix formation, and morphogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650209
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  • 150
    Digitale Medien
    Digitale Medien
    The nature of the litter size loss in senescent hamstersThis work was supported by Atomic Energy Commission Grant AT45-1-1926 and Training Grant 2T1 GM336 from the N.I.H., U.S.P.H.S.; and is based on part of a dissertation submitted by I.H.T. in partial fulfillment of the requirements for the degree of Doctor of Philosophy in biology at the University of Oregon. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 343-348 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Young and senescent female hamsters were sacrificed on days 8, 10, 12, 14 and 15 of pregnancy, and the number of viable and resorbing conceptuses was determined. The ovulation rate for each group was also recorded. At each day, there was a reduction in the litter size in senescent animals as compared to the young, but the number of ovulations in each age group was equal. The results indicated that the litter size loss, in senescent hamsters, is not due to a reduction in the ovulation rate, but to a seven fold increase in preimplantation deaths and to a two fold increase in resorption.
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650303
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  • 151
    Digitale Medien
    Digitale Medien
    H3-leucine incorporation in antigenically stimulated rat popliteal lymph node cells (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 363-377 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The effect of antigenic stimulation with pertussis and sheep red blood cell antigens was studied in the rat popliteal lymph nodes. H3-leucine was used to assess protein metabolism in the various cell types of the reactive lymph nodes following both primary and secondary stimulation with these antigens. Radioautographs of tissue smears were used to make quantitative and qualitative assessments of the extent of intracellular protein synthesis. In addition, changes in the cellular populations of various lymphoid cell lines were determined utilizing differential cell counts and total cells present in the reacting nodes. These data were used principally to assess the role of the lymphocytic cells in the ontogeny of the immune response.Large and medium lymphocytes responded to antigenic stimuli by increasing intracellular protein synthesis. This newly synthesized protein most likely reflected the requirements of large and medium lymphocytes for growth, division and the production of immunoglobulins. The small lymphocytes, as a group, showed only minimal changes in intracellular protein synthesis following antigenic stimulation.The responses by large and medium lymphocytes and plasma cells were qualitatively similar following primary and secondary stimuli. The differences in these responses appeared to be reflected by the number of cells involved and by the temporal sequence in which the cells appeared.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650306
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  • 152
    Digitale Medien
    Digitale Medien
    Responses of fatty livers of mice to carbon tetrachlorideSupported by grant HE-07318 and HE-04052 from the National Institutes of Health, U.S.P.H.S. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 391-399 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Female mice of the Taconic Swiss stock were fed one of the three diets described below then injected subcutaneously with 0.035 cm3CCl4/100 gm body weight in a mineral oil solution. One group was fed an adequate commercial laboratory ration, then mice were killed 12, 24 and 48 hours after CCl4; another a cholinedeficient, high-fat, low-protein diet for 14 days, then injected with CCl4, and killed 12, 24 and 48 hours later; and another group, a choline-supplemented (2 gm choline chloride/100 gm diet), high-fat, low-protein diet for 14 days, then injected with CCl4 and killed 24 hours later.In the group fed the normal diet, the polyhalogen produced within 24 hours the expected centrolobular necrosis and glycogen depletion, involving one-third to one-half of the lobular areas. In fatty livers produced by feeding the choline-deficient diet, necrosis at 24 hours post injection was limited in a majority of instances to a zone one or two cells thick immediately surrounding the central vein. Despite this decreased necrosis in fatty livers centrolobular glycogen depletion still involved one-third to one-half of lobules and there was an infiltration of inflammatory cells immediately adjacent to the central vein. The hepatic necrosis at 12 and 48 hours paralleled that in the normal dietary group.Feeding of the choline-supplemented, high-fat, low-protein diet for two weeks produced an extremely limited parenchymal liposis. In such relatively non-fatty livers CCl4 produced hepatic necrosis comparable to that in mice receiving normal diets. The extent of protection from the necrogenic actions of CCl4 was clearly associated with extensive intracytoplasmic liposis of hepatic parenchyma.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650308
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  • 153
    Digitale Medien
    Digitale Medien
    Histoenzymology of the developing human spinal cord (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 59-65 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: In the human fetal spinal cord, enzymatic activity is demonstrated in neurons of the anterior horn a few weeks before it appears in neurons of the posterior horn. This enzymatic activity is present first in the lumbar segment of the spinal cord and with advancing time gradually ascends cephalad. The presence of acetyl-cholinesterase activity in neuronal cytoplasm in the lumbar segment of the spinal cord coincides with the earliest detectable movement in the lower limbs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630107
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  • 154
    Digitale Medien
    Digitale Medien
    Observations on the distribution of intrarenal nervous tissue (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 81-88 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The distribution of intrarenal nervous tissue in a number of species has been examined using a cholinesterase technique. Particular attention has been paid to the relationships between the renal vessels and their nerves. Nerves were detected alongside the major intrinsic renal vessels and formed nerve networks on the external aspects of the arterial tunicae mediae. In all specimens, afferent arterioles were accompanied by nerves the majority of which terminated near the entrance of cortical afferent arterioles into their respective glomeruli; nerves along juxtamedullary afferent arterioles continued across glomerular hila. Relatively few nerves were demonstrated near cortical efferent arterioles while juxtamedullary efferent vessels possessed a rich innervation. Intramural smooth muscle was identified in juxtamedullary efferent arterioles, aglomerular vessels and arteriolae rectae and these vascular segments were accompanied by nervous tissue. Cholinesterase positive nerves could not be detected in the renal medulla.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630110
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  • 155
    Digitale Medien
    Digitale Medien
    Editorial (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 133-133 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630201
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  • 156
    Digitale Medien
    Digitale Medien
    American Association of Anatomists. Eighty-second annual session; Boston University School Of Medicine, Harvard Medical School, University of Massachusetts School of Medicine, Tufts University School Of Medicine, April 1, 2, 3, 4, 1969. Officers, abstracts, demonstrations (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 139-347 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630203
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  • 157
    Digitale Medien
    Digitale Medien
    A correlative investigation of the human rectovaginal septum (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 443-451 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Anatomists and gynecologists have debated the existence of a rectovaginal septum in the human female. In this investigation the connective tissue between the vagina and rectum has been reexamined by both dissection and light microscopy in four specimen types. Specimens studied and compared totaled 143 and represent an age range of from eight fetal weeks to 100 years. Included were specimens from patients with different degrees of parity and both normal and abnormal pelvic visceral support.It has been shown that a definite rectovaginal septum exists in the human female and it is probably the homologue of the male rectovesical septum. The septum is well formed by the fourteenth fetal week and consists of a thin vertical sheet of dense connective tissue which is translucent in the fresh state. In the coronal plane the septum parallels the sacral curvature. It also curves posterolaterally to become fused with the parietal endopelvic fascia. The septum extends inferiorly from the rectouterine peritoneal pouch to the perineal body. It is usually adherent to the posterior aspect of the vaginal connective tissue, capsule. This adherence, together with the difficulty in identifying it histologically may explain why the existence of the rectovaginal septum has been denied.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630307
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  • 158
    Digitale Medien
    Digitale Medien
    A quantitative study of the blood vessels of the pig's skin and the influence of environmental temperature (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 517-524 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The vascular supply to the skin of pigs was studied in animals perfused with the dye, monastral fast blue. The arrangement of the blood vessels in control animals was in three plexuses, similar to that in other mammals but with the middle plexus poorly developed.A litter of pigs was divided into two groups at the age of 12 days and one group was raised in a warm room and the other in a cold room. The pigs were killed at age three months when the warm room was 35°C and the cold room 5°C. A quantitative evaluation of the blood supply to the skin of the experimental animals revealed that the pigs from the warm room had more blood vessels in the skin than those raised in the cold; the difference was statistically significant (P 〈 0.01). In the case of pigs from a second litter reared at 35°C and 20°C, no significant difference in the number of blood vessels was detected.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630404
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  • 159
    Digitale Medien
    Digitale Medien
    Spontaneous calcification in hearts of DBA miceSupported by grant (HE 04052) from National Institutes of Health, U. S. Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 153-161 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Onset, frequency and characteristics of the spontaneous calcification which occurs in hearts of mice of the DBA strain have been studied. Calcified myocardial lesions developed as early as 25 days of age. A limited inflammatory response was associated with the fine mineral granules of early lesions. With age, sites of calcium deposition became larger and agranular. There was no evidence of inflammation at such loci and adjacent connective tissue did not increase significantly. In the oldest animals (older than 90 days), fibrous encapsulation of calcified sites was typical. Calcareous epicarditis appeared by 30 days; was minimal (8%) through 90 days, and then rose sharply in incidence (50%) in older animals. Epicardial calcification was restricted to the right ventricle. In general the calcified lesions increased with age and were not related to sex. Incidence of all lesions was 17% by 30 days of age, 80% within 90 days, and 94% in mice older than 90 days.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640203
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  • 160
    Digitale Medien
    Digitale Medien
    Introduction (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 107-108 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650113
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  • 161
    Digitale Medien
    Digitale Medien
    The The non-thymic origin of lymphocytes (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 109-112 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650114
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  • 162
    Digitale Medien
    Digitale Medien
    The role of lymphocytes in antibody formation and delayed-type hypersensitivity (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 117-119 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650116
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  • 163
    Digitale Medien
    Digitale Medien
    Masthead (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969) 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650201
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  • 164
    Digitale Medien
    Digitale Medien
    Ultrastructure of schwann and perineural sheaths at the mouse neuromuscular junction (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 379-390 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Intramuscular nerve branches are covered by a complex of epithelial sheaths which decrease in thickness and complexity as the nerves branch to reach ultimate termination of neuromuscular junctions. The outermost layer (epineurium) of intramuscular nerves is composed of thin processes of fibrocytes lacking basement lamina and associated with parallel bundles of collagen. Internal to this layer are two or three layers of interdigitating perineural cells covered with basement lamina. The innermost layer is frequently incompletely covered by basement lamina within the perineural sheath. Schwann cells covered with basement lamina enclose myelinated and unmyelinated axons.In the region of neuromuscular junctions, the basement lamina of Schwann cell processes merge with the myofiber basement lamina. Thin perineural cell processes form a bell-shaped covering which does not reach the muscle basement lamina. The relationships of myelin to the axon as the terminal axon emerges from the Schwann cell closely resembles the relationships of these structures in nodes of Ranvier.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640401
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  • 165
    Digitale Medien
    Digitale Medien
    Stratified squamous metaplasia of the uterine epithelium in early androgen-treated rats and its inhibition by light deprivationSupported by grant HD-02937 U. S. P. H. S. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 479-487 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Rats, having been given a single subcutaneous injection of testosterone propionate at four days of age, exhibited polyfollicular ovaries, extensive stratified squamous uterine metaplasia and persistent vaginal cornification (90-95% of the smears contained cornified cells) after adulthood was attained. If early androgentreated rats were blinded at 22 days of age the number of vesicular follicles in the ovaries of adults was greatly diminished, the incidence and extent of stratified squamous metaplastic lesions were suppressed and the number of vaginal smears containing cornified cells was reduced by about 50%. The effects of blinding, however, were negated by pinealectomy illustrating that the suppressive influence of light deprivation on reproduction was mediated by way of the pineal gland.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640406
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  • 166
    Digitale Medien
    Digitale Medien
    Fine structure of the dermal luminescent organs, photophores, in the fish, Porichthys notatusThis investigation was supported by USPHS predoctoral fellowship number 5-F1-GM-29.402, and in part by USPHS training grant GM 136, and is a portion of the work submitted to the University of Washington Graduate School in partial fulfillment of the requirements for a Ph.D. degree. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 433-461 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Photophores in Porichthys notatus consist of a cellular lens, an underlying area of photogenic tissue and a deep ensheathing reflector. Lens cells exhibit a dense compacted filamentous cytoplasm. Their processes interdigitate and desmosomes exist along their borders. The photogenic tissue, richly supplied by blood vessels, consists of two main cell types: (1) a presumed “photogenic” cell; and (2) a supportive cell. Photogenic cells are characterized by a highly vesiculated cytoplasm and peripheral microvilli. Frequently, they exhibit lamellar membranous whorls. Some whorls display cytoplasmic cores with vesicles. Many of these vesicles communicate via pores with an extracellular channel that envelops the cells. Supportive cells contain cytoplasmic filaments and extend processes around the photogenic cells. Except for isolated desmosomal contact points, a wide extracellular channel intervenes between supportive and photogenic cells. A prominent basal lamina separates supportive cells from the surrounding connective tissue. The strongly birefringent reflector is composed primarily of cells containing guanine crystals. The crystals lie stacked in groups, each membrane-bounded crystal being separated from its neighbor by an intervening layer of cytoplasm. Such an arrangement produces constructive interference and accounts for the high reflectivity of this multilayered structure. Possible relationships of the above structural features and the production of light are discussed.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640404
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  • 167
    Digitale Medien
    Digitale Medien
    Nuclear and cytoplasmic annulate lamellae in trophoblast giant cells of rat placentaSupported by a Research Grant from the National Institutes of Health (HD-00569) (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 1-13 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Single stranded profiles of nuclear annulate lamellae were identified in giant cells of rat trophoblast from the day when the chorioallantoic placenta first becomes vascularized, viz., day 12 post coitum, until the day before term, viz., day 22. Cytoplasmic annulate lamellae were observed only in giant cells from placentas at day 12. Occasionally cytoplasmic annulate lamellae were found in parallel array. Often the lamellar membranes were continuous with both granular and agranular membranes of endoplasmic reticulum; they closely resembled doubled outer nuclear membrane. Nuclear annulate lamellae resembled doubled inner nuclear membrane; and often the two were found in continuity. In addition, at later gestational ages (17 and 22 days), nuclear lamellae often were related anatomically to the variety of nuclear inclusions which characterize giant trophoblast cells during late pregnancy. A possible relationship of annulate lamellae to the synthesis of DNA, RNA and protein is considered.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650102
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  • 168
    Digitale Medien
    Digitale Medien
    A quantitative study of the nucleus of the mesencephalic tract of the trigeminal nerve of the catSupported by U.S.P.H.S. grants GM 1084 and DE 02259. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 79-87 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The number of cells in the mesencephalic nuclei of 38 cats averaged 2015 and ranged from 1237 to 2946. The individual right and left nuclei averaged 980 cells and ranged from 581 to 1489. About 3% of the cells were chromatolytic in the control animals.Various nerves were sectioned and the animals were sacrificed 14 days later. After unilateral section of the nerve to the masseter muscle 18% of the cells in the ipsi- and 9.7% of the cells in the contralateral nuclei were chromatolytic. After simultaneous unilateral section of the nerves to both the masseter and temporalis muscles 3% of the ipsi- and 23% of the cells of the contralateral nuclei were chromatolytic. After unilateral section of the inferior alveolar nerves 13% of the cells of the ipsi- and 9% of the cells of the contralateral nuclei were chromatolytic. After unilateral section of the lingual nerves 9% of the cells of the ipsi- and 7% of the cells of the contralateral nuclei were chromatolytic. After unilateral section of the hypoglossal nerves 12% of the ipsi- and 10% of the cells of the contralateral nuclei were chromatolytic.These results provide anatomical evidence that the axons of the cells of the mesencephalic nuclei are distributed to both the ipsi- and contralateral peripheral nerves. These findings also confirm the presence of such axons in the lingual and inferior alveolar nerves and demonstrate their heretofore unsuspected presence in the hypoglossal nerve.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650109
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  • 169
    Digitale Medien
    Digitale Medien
    Ovarian morphological and functional changes in reproductively senescent hamstersThis work was supported by Atomic Energy Commission Grant AT45-1-1926 and Training Grant 2T1 GM336 from the N.I.H., U.S.P.H.S.; and is based on part of a dissertation submitted by I.H.T. in partial fulfillment of the requirements for the degree of Doctor of Philosophy in biology at the University of Oregon.Some preliminary results of this study have appeared in abstract form (Thorneycroft, I. H., and A. L. Soderwall 1968 Fed. Proc., 27; 739) (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 349-354 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Ovaries from young and senescent hamsters were examined morphologically on days 8, 12 and 14 of pregnancy to determine if there were any differences between the two age groups. The senescent hamsters had fewer follicles present than the young on all days of gestation. The senescent females' corpora lutea experienced the greatest growth between days 8 to 12, whereas corpora lutea from young animals grew the most between days 12 and 14. Corpora lutea in senescent females did not grow at all between days 12 and 14. The lower number of follicles in senescent females was not due to the lower rate of implantation. Superovulation with PMS revealed that the senescent ovary was refractory.It was concluded that there are quantitative not qualitative differences between ovaries from young and senescent hamsters during pregnancy. The refractory ovary of senescent females could be contributing to pregnancy wastage in this species by secreting less progesterone.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650304
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  • 170
    Digitale Medien
    Digitale Medien
    Electromyography of genioglossus and geniohyoid muscles during deglutitionSupported by grants from the Medical Research Council and Defence Research Board of Canada to J. V. Basmajian. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 401-409 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: An electromyographic investigation of the activity of the paired genioglossus and geniohyoid muscles of twenty-six human subjects during deglutition revealed a general pattern of muscular activity involving an initial build-up, gradual summation, and tapering of electrical potentials during swallowing of both saliva and water. There is an observable difference in the pattern of swallowing of individuals within a group and among the individual swallows of a single subject. There are longer periods of electrical activity during a saliva swallow than during a water swallow. The type of bolus also seems to affect the pattern of activity in the individual muscles as well as the length of time that they are working. The geniohyoid muscles do not appear to begin their activity with the genioglossus muscles but rather lag behind and they do not appear to be active for as long. Both pairs of muscles appear to remain active during and after the time that the bolus has passed the area of the laryngopharynx. A period of electrical silence occurs prior to the characteristic burst of activity associated with a swallow. This appears to be the result of an active inhibition.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650309
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  • 171
    Digitale Medien
    Digitale Medien
    The placenta of the four-eyed opossum (philander opossum)Philander opossum)Supported by grant 5 RO1 HD02613 from the National Institute of Child Health and Human Development. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 431-449 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The placental membranes of the four-eyed opossum were studied by light and electron microscopy. The individual fetuses in each uterus were surrounded by amnion, had allantoic sacs of approximately the same size as each fetus, and were situated in a common yolk sac cavity. The extent of the choriovitelline placenta was marked by a prominent sinus terminalis, and at this margin there was a region where the trophoblast cells penetrated folds of the endometrium. Elsewhere the choriovitelline placenta was closely applied to the uterine epithelium along most of its surface, but the microvilli of the two epithelia did not interdigitate. Numerous inclusion bodies were seen in the trophoblast of both the choriovitelline and bilaminar omphalopleure portions of the placenta, but the aggregates were larger in the latter. The endoderm cells of the choriovitelline placenta had extensive endoplasmic reticulum and numerous mitochondria, but did not have conspicuous absorption canaliculi.Placentation in the four-eyed opossum appears to represent a progressive advance over that of the Virginia opossum both in confluence of the yolk sacs of the fetuses and in having a region of penetration of the maternal endometrium by trophoblast.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650311
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  • 172
    Digitale Medien
    Digitale Medien
    Observations on the fine structure of peripheral nerve myelinSupported by grants AM 0943-03, AM-10628 National Institutes of Health, USPHS; and National Multiple Sclerosis Society 442.This paper has appeared in abstract form (Scallen, T. J. and L. M. Napolitano, 1968. A modified aldehyde fixative for electron microscopy: studies on myelin). Fed. Western Soc. Neurological Sc., Symposium on Neurochemistry, San Diego, Calif. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 1-6 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The incorporation of digitonin 0.2% w/v in cacodylate buffered glutaraldehyde reduces the amount of cholesterol extracted in the dehydrating (lipid extracting) solutions. The fixative enhances membrane structure and results in the preservation of a double minor period in peripheral myelin. The periodicity obtained is in agreement with those derived from x-ray diffraction studies.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630101
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  • 173
    Digitale Medien
    Digitale Medien
    Light and electron microscopic studies on cellular alterations in the normal bovine placentome (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 17-29 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Placentomes from 12 cows ranging from about 45 days of gestation to full term were studied with light and electron microscopy. The cryptal epithelium and the trophoblast both comprised uninucleate, binucleate and multinucleate cells. The uninucleate cryptal cells were provided with small mitochondria and essentially rough-surfaced endoplasmic reticulum of varying appearance. The uninucleate trophoblastic cells were characterized by an abundance of mitochondria and by morphological evidence of absorption (pinocytosis and phagocytosis). Mitotic figures and sites with cellular degeneration were frequent on the cryptal side but less so on the trophoblastic side. It is concluded that cell turnover is rapid, being confined mainly to the cryptal cells. This is a process in the continuous growth and remodelling of the placentome. There is morphological evidence that the degenerated cells are absorbed by the trophoblast.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630103
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  • 174
    Digitale Medien
    Digitale Medien
    Fenestrated cisternae in the Golgi apparatus of the epididymisSupported by a research grant from the American Cancer Society (E-500), program project HD-002282 of the National Institutes of Health, and Health Sciences Advancement Award (FR-06084) from the National Institutes of Health. The author is the recipient of a Research Career Development Award (1-K3-GM-28.214-01) from the National Institute of General Medical Sciences. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 39-53 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Attention is directed toward the occurrence of fenestrations or pores in Golgi cisternae of rat and mouse epididymis. There is a gradation in the degree of cisternal fenestration within a Golgi complex. Cisternae at the convex pole are highly flattened and contain few pores, but those near the concave side are distended and exhibit a large number of roughly circular fenestrations 300-600 Å in diameter. Cisternae in the middle of a stack often have an unperforated central portion that is surrounded by a fenestrated and expanded peripheral region. The structure of these Golgi complexes is compared with previous descriptions of Golgi cisternae, particularly the fenestrated cisternae reported in plant cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630105
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  • 175
    Digitale Medien
    Digitale Medien
    Alterations in blood vessels in X-irradiated spinal cords of young rats (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 89-99 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Administration of x-rays (4000 r) to lumbar spinal cords of three-day-old rats caused a loss of neuroglia with an inhibition of myelinogenesis, neuronal damage and necrosis. In contrast, the loss of neuroglia following administration of 2000 r is temporary, with myelinogenesis occurring later than normal. Preliminary observations suggested that differences in vascular responses to these two amounts of x-rays might account for these differing fates of the spinal cords; therefore, this investigation was designed to study further the reactions of the intramedullary vessels.Rats, irradiated when three days of age, were killed 1 to 27 days later. Some were killed by perfusion with Monolite Fast Blue BNVSA Paste, a substance retained in the vessels and readily visualized on microscopic examination. The remaining rats were decapitated, and spinal cords were stained by Gomori's method for alkaline phosphatase. The earliest consistent alteration, a decreased number of vessels, was noted seven days following irradiation with either dose. Rats receiving 4000 r had marked losses of blood vessels, vasodilatation and necrosis by 15 days post-irradiation; whereas, a decreased number of vessels was the only change noted in rats irradiated with 2000 r. Alterations in rats receiving 4000 r remained the same or became more severe throughout the study; spinal cords in rats receiving 2000 r returned to normal. These vascular alterations correlate well with the changes in other spinal cord components described previously by this investigator.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630111
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  • 176
    Digitale Medien
    Digitale Medien
    Ultrastructure of uterine smooth muscle following progesterone or progesterone-estrogen treatmentSupported by USPHS grants AM-08029, HD-01357 avid HD-00606. The investigators are grateful to Dr. Norman Sulkin for making the electron microscope available. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 121-131 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The ultrastructural effect of progesterone, alone and in combination with estrogen, on smooth muscle cells of the rat uterus was studied. Adult, bilaterally ovariectomized rats were untreated (controls) or treated with either progesterone (1 mg), estrogen (1 μg) or both on three consecutive days.Uterine muscle cells appeared larger and myofilaments more abundant in the progesterone-treated rats than in the other groups of animals. Many micropinocytotic vesicles and several dense bodies were present in muscle cells of control, progesterone and estrogen-progesterone-treated rats. In the progestrone-treated group, smooth muscle cells contained little granular endoplasmic reticulum and few ribosomes and glycogen particles, similar to the controls. Mitochondria were more numerous than in the control animals but similar to those seen in the estrogen or estrogen-progesterone-treated rats. Although an accumulation of granular endoplasmic reticulum, free ribosomes, glycogen particles and extensive Golgi complexes occurred in both estrogen and estrogen-progesterone-treated rats, they were more extensive in the former group.The observations indicate that progesterone alters the ultrastructure of the smooth muscle cells but not to the degree observed following estrogen stimulation. It does not markedly inhibit the effect of estrogen on the fine structure of the uterine smooth muscle cells. These observations support previous biochemical studies on glycogen concentration, RNA and protein synthesis in the rat uterus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630114
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  • 177
    Digitale Medien
    Digitale Medien
    Effects of X-irradiation of immature hamsters on growth and development of gonadsSupported by a grant (GM 14370) of NIH, P. H. S. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 353-358 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Hamsters were x-irradiated at 300 R on 1, 7, 14, 21 or 30 days after birth and sacrificed at the age of 33 days.The body weight, testicular weight and the development of seminiferous tubules were severely affected by irradiation on day 1. The ovarian weight and the number of oocytes were more affected by irradiation on day 7 or 14. Effects of irradiation of immature hamsters on their growth and development of gonads appears to be permanent as irradiation of males on day 1 destroyed all their germ cells by day 33 and irradiation of females on day 7 caused their permanent sterility up to four months of age.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630301
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  • 178
    Digitale Medien
    Digitale Medien
    Myofibrillogenesis and Z-band differentiation (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 403-425 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Developing myotubes in skeletal muscle tissue from the limbs of larval newts have been examined with respect to the ultrastructure and sequence of events accompanying myofibril formation. A population of filaments having a diameter of 100 Å is found to occur throughout and beyond the period of myofibrillogenesis. This population is in addition to developing actin and myosin filaments and probably does not contribute directly to myofibril formation. Rather it may represent a cytoskeletal network which ultimately becomes principally disposed around and at right angles to older myofibrils at the level of their Z-bands.Assembly of thick and thin filaments into myofibrils seems to occur, in this muscle, predominantly near the periphery of the cell with registration of these components into A-, I-, and Z-bands being accomplished as they assume progressively more internal locations. Z-bands appear to develop by coalescence of Z-bodies which in turn are earlier related to skeins of fine filamentous material which commonly occupy the most peripheral cytoplasm of these and other mesenchymally derived cells. Fine structural details of these skeins, Z-bodies, and Z-bands have been analyzed with regard to the several prevailing concepts of Z-band architecture. An hypothetical sequence for myofibril formation and Z-band differentiation is presented which takes into account several observations and relates them to the looping filament configuration previously proposed for mature Z-band structure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630305
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  • 179
    Digitale Medien
    Digitale Medien
    The fine structure of rabbit platelets fixed in acetaldehydeThis work was supported by grants from the Medical Research Council of Canada (MA 2182) and the Ontario Heart Foundation. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 509-516 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The morphology of platelets fixed in acetaldehyde and postfixed in osmium tetroxide was compared with that of platelets fixed in glutaraldehyde followed by osmium tetroxide. Many platelets became rounded after acetaldhyde fixation. Membranes, granules and mitochondria were well preserved and cytoplasmic microfilaments became apparent. Very dense granules were obvious after acetaldehyde fixation alone and after acetaldehyde/glutaraldehyde/osmium tetroxide triple fixation, but not after acetaldehyde/osmium tetroxide double fixation. Microtubules were never seen. Intracytoplasmic vacuoles assumed exaggerated prominence. The authors relate the alterations in the vacuolar system and changes in platelet shape to a loss of cytoplasmic microtubules. They suggest that the changes are induced, in part by the low temperature of fixation, and in part by the weak fixative action of the aldehyde.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630403
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  • 180
    Digitale Medien
    Digitale Medien
    The subarachnoid angle: An area of transition in peripheral nerveSupported by HE 09041, United States Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 15-33 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The lateral limit of the subarachnoid space, where nerve roots enter and leave, forms the subarachnoid angle. This is an important site of transition for nerve sheaths. Here the perineurium of peripheral nerve leaves the surface of the nerve and extends between the dura mater and the arachnoid. The perineurium is therefore open-ended with respect to the subarachnoid space. The central perineurial extension is histologically the same as perineurium in some areas but in others forms a layer of hydrated cells without basement membranes. These lie in close apposition with the outermost cells of the arachnoid membrane. At the subarachnoid angle the arachnoid membrane may either reflect onto the root sheath or be attached to it by punctate junctions. The root sheath covers the nerve roots as they pass through the subarachnoid space. It is composed of loosely arranged cells bound by punctate junctions. Its intercellular spaces may contain connective tissue fibrils. A single basement membrane separates it from the endoneurium. The histological structure in the region of the subarachnoid angle is consistent with clinical evidence implicating the endoneurium of nerve trunks as a pathway for the transmission of infection from the periphery to the central nervous system.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640102
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  • 181
    Digitale Medien
    Digitale Medien
    The significance of intramedullary cancellous bone formation in the repair of bone marrow tissueThese studies were aided with funds from the Atomic Energy Commission contract AT (30-1) 3808 and U. S. Public Health Service grant AM 12444-01 from the National Institute of Arthritis and Metabolic Diseases. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 101-111 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The repair of hemopoietic bone marrow following evacuation of the tibial or femoral cavity of the rat was sequentially studied with the light microscope. A stereotyped train of histologic events occurred. These were capillary invasion of the cavity, appearance of primitive mesenchymal cells, osteoblastic proliferation, cancellous bone formation, development of sinusoids, reappearance of hemopoietic tissue and resorption of cancellous bone. The studies suggest that restoration of marrow sinusoids takes place only in the interstices of cancellous bone. Mechanical disruption of the sinusoidal system is one method of triggering cancellous bone formation. The cancellous bone which appeared after injury was thought to be produced by endosteal osteoblasts and osteoblasts derived from cells residing in normal hemopoietic tissue. Localized radiation of the tibia followed by mechanical disruption of hemopoietic tissue demonstrated that cancellous bone production and the repair process were unimpaired by 1,000 r but were completely blocked by 4,000 r. This would imply that the cell which can differentiate into an osteoblast is resistant to 1,000 r.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640107
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  • 182
    Digitale Medien
    Digitale Medien
    The ultrastructure of sympathetic ganglia of the lizard Cnemidophorus neomexicanusThis study was performed during the tenure of a post-doctoral fellowship to Gene L. Colborn supported by N.I.H. grant 1-RO1-GM14435-02. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 185-203 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Sympathetic ganglia of six Cnemidophorus neomexicanus lizards were fixed by immersion with glutaraldehyde or a combination of glutaraldehyde and paraformaldehyde. All ganglia were post-fixed in 1% osmium tetroxide and embedded in Epon.Neuronal somata and processes of stellate ganglia were ensheathed typically by capsular cell cytoplasm and membranes; however, parts of some processes were invested only by basement membrane. Axo-somatic, axo-dendritic and axo-axonal synapses were observed. Pre- and post-synaptic processes contained 200 Å neurotubules, 100 Å neurofilaments, 225-500 Å presumptive glycogen granules and occasional multivesicular bodies. Presynaptic endings contained 500-700 Å “clear” vesicles and a few dense-cored vesicles of 600-1100 Å.Aggregates composed of 225-500 Å granules, presumably glycogen, were frequently found in peripheral perikaryal positions in intimate association with lipid droplets. Clusters of particles within somata were also found which resembled ribosomes but were not associated with endoplasmic reticulum or vesicular membranous elements. These clusters, perhaps “areticular Nissl substance,” were associated in some instances with fibrillar material or lattice-like granular structures. Abundant and frequently large lipid droplets were observed in proximity to the ribosomal-like particulate material.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640206
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  • 183
    Digitale Medien
    Digitale Medien
    Lysosomes in uterine involution: Distribution of acid hydrolases in luminal epitheliumThis investigation was supported by grants HD 00042, National Institute of Child Health and Human Development, and CA 08518 from the National Cancer Institute, National Institutes of Health, U.S. Public Health Service. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 231-251 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The distribution of acid hydrolytic activities in rat uterine epithelial cells during post-partum involution was examined by light and electron microscopic cytochemistry. Acid phosphatase, β-glucuronidase, N-acetyl-β-glucosaminidase and E600-resistant esterase (cathepsin) increased during the period of involution and the electron cytochemical preparations revealed the lysosomal nature of the acid hydrolytic positive particles visualized by light microscopy.The newly formed particles included primary lysosomes, in the form of Golgi vesicles, vacuoles, and secondary lysosomes such as dense bodies and autophagic vacuoles. This apparent increase in lysosomal activity during uterine involution is in agreement with similar patterns observed in the course of tissue regression in general.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640209
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  • 184
    Digitale Medien
    Digitale Medien
    The effects of fluoride and low calcium on the physical properties of the rat femur (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 305-316 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The effect of fluoride on the physical properties of bone was investigated with the aid of an Instron materials tester. Two groups of weanling female rats, one on an adequate (0.6%) calcium diet and the other on a low (0.1%) diet were given the following dosage levels of fluoride (as NaF) in their deionized drinking water over a fifteen and one-half week period: 3.4 ppm, 10.0 ppm and 45.0 ppm. In the adequate calcium group a significant increase in flexibility in the rat femur was found only at the 45.0 ppm dosage level. This was not offset by a significant decrease in strength. In the low calcium group a similar significant increase in flexibility appeared at the 10.0 ppm dosage level as well as the 45.0 ppm, but a significant decrease in strength at the two dosage levels was observed. These were in direct relation to the amount of fluoride given.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640306
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  • 185
    Digitale Medien
    Digitale Medien
    Maintenance of gestation in hypophysectomized rats with highly purified pituitary hormones (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 291-303 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Pregnancy was maintained in Long-Evans rats hypophysectomized on day 1 and injected with ovine pituitary gonadotrophins from day 1 through day 11; and also in rats hypophysectomized on day 6 and injected from day 6 through day 11. For successful maintenance until term, no further injections were necessary after day 11. The combination of hormones considered close to optimal was; mammotrophin 2.5 mg; follicle-stimulating hormone 25 μg; and interstitial cell-stimulating hormone 5 μg injected daily, subcutaneously. Histological examination of ovaries after this regimen (on day 12) revealed interstitial and luteal tissue that was considered normal for this stage; and follicles that were in some cases larger than expected and occasionally with theca luteinization. The ovaries of the rats allowed to go to term and untreated after day 11 showed follicular and interstitial tissue that had regressed and well-stimulated corpora lutea. These findings showed no evidence of placental FSH or ICSH-like hormones; but confirmed earlier reports of a rat placental luteotrophic hormone.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640305
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  • 186
    Digitale Medien
    Digitale Medien
    Light and electron microscopy of the adrenal medulla of macaca mulata monkeyThis work was supported in part by a grant from the Vermont Heart Association. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 317-332 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The fine structure of the adrenal medulla of Macaca mulata monkey was studied after double fixation with paraformaldehyde and OsO4; other fixations were employed for comparison. Only one cell type was seen. The cytoplasm contained an uneven distribution of chromaffin vesicles which were either spherical or elongated and 0.1-0.3 μ in diameter. There were two principle vesicle categories: dark and compact forms which comprised the majority (about 80%) and lighter, mostly larger, vesicles with a finely granulated appearance. The Golgi apparatus was often seen in relatively clear areas where few other organelles were present. Vesicles, 0.1-0.2 μ in diameter, which stained heterogeneously were also observed. They were few in number and always associated with the Golgi apparatus. The chromaffin cells lay in close proximity, but in no specific relationship, to thin-walled blood vessels. Nerve endings which were partially embraced by Schwann cells were in synaptic relation to the chromaffin cells.These findings are compared with previous observations in other mammals and the nature of the dark and light vesicles is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640307
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  • 187
    Digitale Medien
    Digitale Medien
    Hair growth cycles in subcutaneous implantsSupported in part by American Cancer Society grant E-392 to Massachusetts General Hospital and USPHS Research grant CA-00592-17 to Brown University. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 333-337 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Skin fragments implanted subcutaneously into syngeneic mice remained viable and showed cyclic hair growth over a period of months. Embryonic skin differentiated into the various layers of epidermis and corium, producing sebaceous glands and hair follicles. Implants from both embryos and newborn displayed normal hair pigmentation with appearance in metanagen of the yellow bands characteristic of the agouti hair for that genotype. Follicles were observed to pass through the various hair growth stages into a resting period and then later to re-enter the growth cycle. There were departures from normal hair growth, however, with some follicular disorganization, especially in the newborn implants, and with areas showing mixed growth stages instead of the follicular synchronization characteristic of the intact mouse.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640308
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  • 188
    Digitale Medien
    Digitale Medien
    The thymus as a lymphoid organThe work herein reported from this laboratory was supported in part by a grant from the Life Insurance Medical Research Fund _ G-68-11. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 113-115 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650115
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  • 189
    Digitale Medien
    Digitale Medien
    Masthead (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969) 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650301
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  • 190
    Digitale Medien
    Digitale Medien
    Age changes in the cranial base of the rabbit (Oryctolagus cuniculus) (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 355-361 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The growth changes in the cranial base of the rabbit between one and 20 weeks after birth have been investigated. The basicranial axis and its anterior extension completed some 50% of their growth during this period in contrast to the posterior extension which had completed 70% before one week. The sphenoethmoidal angle underwent no statistically significant changes despite a decrease in the spheno-maxillary angle indicating that the face became disposed below rather than directly anterior to the braincase. The foramino-basal angle decreased progressively during the period of investigation.The pattern of growth in the linear dimensions of the rabbit cranial base is essentially similar to that already established in man and subhuman primates. The angular changes, however, differ from those in primates where the spheno-ethmoidal and foramino-basal angles follow more closely the developmental patterns of the braincase and facial skeleton.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650305
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  • 191
    Digitale Medien
    Digitale Medien
    Changes in coronary arteries of mice fed a high-fat, low-protein diet followed by a normal dietSupported by grant from the National Institutes of Health, U.S.P.H.S., 5 RO1 HE04052. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 379-389 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Female mice of a Swiss albino stock were fed a high-fat, low-protein, hypolipotropic diet which produces rapid cardiovascular lesions in this stock of mice. Half of the animals were killed after 45 days and the others were placed back on a diet of normal laboratory chow and killed after one, two and three weeks of refeeding.In animals killed after receiving the experimental diet for 45 days small, focal deposits of hyalin in media of large coronary arteries of the right ventricle was the major change.During the first week of recovery (fed a normal diet) the incidence and severity of arterial lesions increased and within individual hearts arteries of all sizes and in both atria and both ventricles were involved. Following hyalinization an acute arteritis developed that involved all layers of the arterial wall and extended into the perivascular space.After two and three weeks recovery the coronary arteries were characterized by a periarterial fibrosis and by a decrease or absence of the leucocytic reaction. A subendothelial hyperplasia of smooth muscle, arranged longitudinally, was accompanied by an increase in reticular and collagenous fibers. Circular smooth muscle in the media was also hyperplastic.
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650307
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  • 192
    Digitale Medien
    Digitale Medien
    Temporal and cytological aspects of fertilization and early development in the guinea pig, Cavia porcellus (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 165 (1969), S. 411-429 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: A study was made of 174 eggs recovered from 58 guinea pigs killed between the first and sixth days after mating, and the cytological details from the stage of sperm penetration to the pre-implantation blastocyst described. Eighty-nine percent of the expected number of eggs were recovered, and 97% of these were fertilized. Embryonic development proceeded from pronuclear and 2-cell eggs on day 1 to pre-implantation blastocysts on day 6, the duration of each of the early cleavage stages being of approximately 24 hours. No progressive loss of embryos was found over this period, all the eggs recovered on days 4, 5 and 6 being regarded as developing normally. Passage of embryos from the Fallopian tubes to the uterus commenced on the afternoon of day 3, and the majority of embryos entered the uterus shortly after this time at the stage of 8- to 16-cells. The tail of the fertilizing spermatozoon was detected in the cytoplasm of all eggs examined on day 1, in most of those examined on day 2, and frequently persisted up to the 8-cell stage. Three dispermic eggs, each containing two distinct cytoplasmic sperm tails, were found: one of these was at the pronuclear stage, the other two being considered of 4- and 6-cells respectively. Properties of adhesiveness were shown by blastocysts recovered shortly before implantation on day 6, but the characteristic “zona processes” were not seen.
    Zusätzliches Material: 7 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091650310
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  • 193
    Digitale Medien
    Digitale Medien
    Reconstitution of the external granular layer of the cerebellar cortex in infant rats after low-level X-irradiation (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 453-471 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The heads of three-day old rats were irradiated with a single dose of 200 r x-ray and the animals were killed afterwards at intervals ranging from ten minutes to five days. Necrosis in the external granular layer of the cerebellum was evident by the fourth hour and the pyknotic cells increased in number up to 12 hours after irradiation. Between 24 to 48 hours all the pyknotic cells disappeared and the width of the layer was drastically reduced. By the third day after irradiation the external granular layer began to increase in width, and by the fourth day it was indistinguishable from normal. In adults of this group the cerebellum appeared structurally normal. In another experiment the cerebellum of rats was exposed from birth onward to 200 r on five successive days. In the animals killed immediately or one day after the last radiation session the external granular layer was totally or subtotally eradicated. In the animals surviving for four days the external granular layer reappeared over many regions of the cerebellum, and by the sixth day after irradiation it was present over its entire surface. In the latter group in animals that survived to 30 and 90 days of age the cerebellum contained a large, though subnormal, population of granule cells, indicating that the reconstituted cells were able to differentiate. These results suggested that the proliferative matrix of the postnatally developing cerebellum may be endowed with regenerative capacity.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630308
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  • 194
    Digitale Medien
    Digitale Medien
    Effect of age on alkaline phosphomonoesterase activity in the adrenals of male miceThis research was supported by National Institutes of Health grant NB-03021. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 473-482 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: This investigation was undertaken to examine the effects of aging on alkaline phosphomonoesterase (Alk Pase) activity in the adrenals of a highly inbred strain of C57BL/10 male mice. A total of 140 male mice were assigned to seven main groups and sacrificed at 1, 4, 8, 12, 16, 20 and 24 months of age for biochemical and morphologic evaluations of adrenal Alk Pase activity. The biochemical findings indicated that while aging may result in a decrease of serum and liver Alk Pase activity, enzyme activity in the adrenals of male mice increases to a maximum level at approximately eight months of age and subsequently decreases at each successive age level. The histochemical findings revealed that the highest concentrations of enzyme activity occurred in the fascicular and reticular zones of sexually mature male mice. There were no major variations in zonal distribution with advancing age. Electron microscopy showed Alk Pase activity along membranes of cortical cells and within the subendothelial space.The progressive increase in Alk Pase enzyme activity up to eight months of age, and the subsequent fall in activity during senescence as well as its absence in the adrenals of female mice provides further support for a role of androgen in mobilizing cortical alkaline phosphomonoesterase activity.
    Zusätzliches Material: 17 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630309
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  • 195
    Digitale Medien
    Digitale Medien
    A comparison of alveolar macrophages and pulmonary surfactant(?) Obtained from the lungs of human smokers and nonsmokers by endobronchial lavageSupported by research grants from NIH (HE 09491-03, HE 12571-01 and I-ROI-GM-14435-02) and from the Council for Tobacco Research U.S.A. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 497-507 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Endobronchial lavage was performed on eight smokers and eight nonsmokers. Centrifugation of lavage fluid produces a sediment consisting of two layers, a lower compact brown layer containing cells and an upper flocculent white layer. The brown layers from the smokers were greater in volume than those from the nonsmokers. Macrophages constituted about 93% of the cells from the smokers and about 63% of the cells from the nonsmokers. These data suggest that more free macrophages occur in the lungs of smokers than nonsmokers. In addition, many of the macrophages obtained from the smokers were filled with cytoplasmic inclusions. The volumes of white layers from the smokers were smaller than those from the non-smokers. One white layer obtained from a nonsmoker was examined in a Wilhelmy balance and proved to be surface-active. This may suggest that surface-active material, pulmonary surfactant, is reduced in lavage fluids from smokers.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630402
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  • 196
    Digitale Medien
    Digitale Medien
    Deciduomal response of the golden hamster uterus (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 163 (1969), S. 563-573 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The deciduomal response to uterine trauma in pesudopregnant hamsters has been studied. Trauma was effected in one uterine horn by leaving a sterile silk thread in the lumen, pulling a thread through the lumen, injecting oil or air into the lumen or crushing the horn with a hemostat. At autopsy the traumatized and untraumatized horns were weighed separately and examined histologically for a deciduomal reaction. The day of greatest uterine sensitivity was found to be day 4 of pseudopregnancy, and maximal deciduomal growth (mean uterine weight ± S.E. = 2582 ± 279 mg) occurred by day 8. No significant further increase in uterine weight was seen by day 9, and by day 10 separation of the deciduoma from the myometrium had begun. Leaving a thread in the uterine lumen produced a significantly greater uterine weight by day 8 than with any other stimulus, but good deciduomal responses (uterine weights of 1679 ± 245, 1255 ± 156 and 1192 ± 219 mg) were induced by oil injection, pulling a thead through the uterus and crushing the uterus respectively. A poor reponse was produced by air injection. At no particular time during day 4 of pseudopregnancy was it possible to demonstrate a peak of uterine sensitivity using as a traumatic stimulus either oil injection or pulling a thread through the lumen. In this respect hamsters differ from both rats and mice, which have well defined peaks of maximal uterine sensitivity.
    Zusätzliches Material: 6 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091630408
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  • 197
    Digitale Medien
    Digitale Medien
    Fine structure of the resorptive cells in the teeth of frogsThis investigation was supported by Public Health Service Research grant DE 02201 from the National Institute of Dental Research. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 1-13 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Teeth undergoing resorption were dissected from the maxillae of frogs and prepared for electron microscopy using standard methods and methods designed to minimize demineralization. The resorptive cells overlapped one another, forming palisades. A central ruffled border was surrounded by a relatively structureless cytoplasmic “seal.” Crystals of mineral were present in the folds of the ruffled borders, and demineralized collagen fibrils were seen in the adjacent matrix in sections treated to prevent demineralization. The surfaces of the cells opposite the ruffled borders displayed numerous small villi.The cytoplasm of the resorptive cells contained a variety of lysosomes in various stages of development, mitochondria, scattered vesicles of endoplasmic reticulum and free ribosomes. Well developed Golgi zones were frequently seen, and occasional sections passed through centrioles. Two centrioles were commonly seen in such sections, but never more. Occasional patches of cytoplasm contained mitochondria and rough-surfaced endoplasmic reticulum, resembling “blast” cell cytoplasm.We concluded that the resorptive cells of several mineralized tissues of various vertebrates are morphologically, indistinguishable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640101
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  • 198
    Digitale Medien
    Digitale Medien
    Eruption pathway formation in the presence of experimental tooth impaction in puppiesSupported by USPHS grant 1 SO 1 FR 5417-04-5. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 67-77 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Eruption of permanent premolars in puppies was studied by implanting stainless steel wires through the mandible to stop eruptive movement well before the teeth were to appear in the oral cavity. Histologic and radiologic comparisons of operated with normal (unoperated) sides disclosed that the eruptive pathway forms for the impacted teeth although their eruptive movements were effectively prevented. This clearly shows that the mechanism of eruption pathway formation is not dependent upon direct and continual pressure on the bone from the erupting teeth. The genesis of pathway formation appeared to be the same for the impacted teeth as for the controls i.e., through continued ostetoclasis in the margin of the stalk of the dental follicle.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640105
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  • 199
    Digitale Medien
    Digitale Medien
    Electron microscope observations on the shell gland mucosa of calcium-deficient hens (Gallus domesticus) (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 127-139 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Calcium-deprivation of three weeks duration causes marked degenerative changes in the shell gland mucosa of the laying hen. The height of the columnar epithelium decreases, but the secretory granules in the columnar epithelial cells and the cilia on the apical cells of the columnar epithelium are preserved. The tubular glands decrease in size and number. The microvilli surrounding the tubular gland lumen disappear. The cytoplasm of the tubular gland cell contains autophagic vacuoles (cytolysomes) and large pigment accumulations, presumably lipofuscin. The changes are due to dietary calcium deficiency, apparently mediated by decreased sex steroid secretion and decreased stimulation of the oviduct. These changes are totally reversible, since the fine structure of the shell gland mucosa of calcium-deprived hens returned to a normal laying diet does not show any signs of degeneration and is identical with the fine structure of the shell gland mucosa of the laying control birds.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640201
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  • 200
    Digitale Medien
    Digitale Medien
    The cilium on mammalian vestibular hair cellsResearch supported in part by USPHS grant RG-06729 and in part by the William F. Milton Fund of Harvard University. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 164 (1969), S. 253-258 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The mammalian vestibular cilium is described. It is shown to be comprised of nine dense outer fibers and an intermittent central density; this stands in contradistinction to vestibular cilia of non-mammalian species that have been shown to be comprised of nine outer doublet tubules surrounding two central tubules. The possible functional meaning of these observations is discussed.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091640301
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