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  • 2020-2023
  • 2010-2014
  • 1990-1994  (9.861)
  • 1985-1989
  • 1965-1969
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  • 1
    Digitale Medien
    Digitale Medien
    Association of anterior ectopic anus and partial absence of levator musculature in a woman with impaired defecation (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 974-976 
    Details
    ISSN: 1530-0358
    Schlagwort(e): Constipation ; Defecography ; Magnetic resonance imaging ; Anterior ectopic anus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 25-year-old nulliparous woman with adult onset constipation and slight anterior displacement of the anus underwent pelvic magnetic resonance imaging and was diagnosed with congenital hemiabsence of the levator ani sling. Impaired defecation was confirmed by anorectal function studies and defecography demonstrated an anterior rectocele, perineal descent at the upper limit of normal, and partial obstruction of defecation, which appeared related to the levator sling abnormality. To our knowledge, this combination of findings has not been previously described as a cause of adult onset constipation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02139109
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  • 2
    Digitale Medien
    Digitale Medien
    A monoclonal antibody (Mab 67) marks type B synoviocytes (1990)
    Springer
    Rheumatology international 10 (1990), S. 103-106 
    Details
    ISSN: 1437-160X
    Schlagwort(e): Synovium ; Synoviocytes ; Monoclonal antibody ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The functionally important lining cells of the synovium (types A and B synoviocytes) are the subjects of much study but have presented problems with their characterization and microscopical identification, particularly at the light level. Type A (macrophage-like) synoviocytes, however are more easily localized than the type B (fibroblast-like) variety because of the greater availability of antimacrophage antisera. We describe, using light and electron microscopy, a monoclonal antibody which in the synovial intimal layer is specific for type B synoviocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02274823
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  • 3
    Digitale Medien
    Digitale Medien
    Volume determinations of the encephalic ventricles with CT and MRI (1990)
    Springer
    Surgical and radiologic anatomy 12 (1990), S. 59-64 
    Details
    ISSN: 1279-8517
    Schlagwort(e): Cerebral ventricular volume ; Cerebrospinal fluid volume ; Volume of encephalic ventricles ; Computerized tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Le volume des ventricules cérébraux a été mesuré à partir d'explorations en résonance magnétique. Il existe de nombreuses conditions pathologiques qui peuvent provoquer un élargissement ventriculaire, telles que la maladie d'Alzheimer et l'hydrocéphalie. La mesure précise de la taille des ventricules peut être d'importance pour le diagnostic de ces affections. Elle fournit également d'excellents critères de surveillance des patients porteurs de telles maladies. Notre objectif a été poursuivi au cours d'études séparées en 3 parties. Ce travail rapporte les résultats obtenus durant la première phase de cette étude. Celle-ci démontre qu'il est possible de mesurer les espaces liquidiens en IRM sur 3 fantômes ventriculaires (cavités petites, moyennes et larges). Les résultats ont été comparés avec ceux obtenus en examen tomodensitométrique des mêmes préparations. Des calculs volumétriques ont été obtenus à l'aide d'un analyseur numérique Calcomp 9 000 programmé pour corriger les facteurs d'agrandissement et les épaisseurs de coupe. L'étude des résultats des mesures de volume des cavités ventriculaires obtenus sur ces fantômes démontre que ceux-ci sont plus précis en coupes IRM qu'en coupes tomodensitométriques. La différence moyenne entre ces volumes obtenus en imagerie et les volumes réels calculés par mesure d'espaces liquidiens était de 15,8 % pour les coupes scanographiques et 8,3 % pour l'IRM.
    Notizen: Summary The volume of the encephalic ventricles was determined from magnetic resonance imaging (MRI) scans. Since there are many conditions in which the encephalic ventricles become enlarged such as Alzheimer's disease and hydrocephalus, accurate measurement of the ventricles provides a valuable and safe means of aiding the diagnosis of such conditions and also provides important follow-up information in affected patients. The objective was pursued in a three phase study. This paper presents the data obtained from the first phase. This first phase demonstrated the possibility of measuring fluid filled spaces by MRI in three phantom preparations (small, medium, and large “ventricles”). The results were compared with those obtained from computerized tomography (CT) scans of the same preparations. These volumetric calculations were done with the aid of a Calcomp 9,000 digital analyzer programmed to compensate for the scale factor and slice thickness of the images. The phantom study showed that the results obtained from the MRI scans were better than those obtained from the CT scans in measuring the volume of water-filled cavities (ventricles) in gelatin phantoms. The average percent difference between volumes obtained by an imaging procedure compared to the actual volume as determined by water displacement was 15.8% for CT scanning and a more impressive 8.3% for MRI.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02094127
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  • 4
    Digitale Medien
    Digitale Medien
    Beitrag zur Erklärung unspezifischer serologischer Reaktionen in fauligem Knochengewebe (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 593-598 
    Details
    ISSN: 1437-1596
    Schlagwort(e): ABO in bones ; Putrification ; Extraction ; Immunohistochemistry ; ABO an Knochen ; Fäulnis ; Extraktion ; Immunhistochemie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Knochenteile wurden in Wasser bei Raumtemperatur 2 Jahre aufbewahrt and anschließend serologischen Untersuchungen unterzogen. Zur Anwendung kamen folgende Untersuchungsmethoden: Absorptions-Elutionstest, Extraktion von Blutgruppensubstanzen, Immunhistochemie (PAP). In frischen Knochen ergaben alle 3 Methoden im wesentlichen spezifische Ergebnisse. In faulen Knochenproben zeigten das Absorptions-Elutions-und das PAP-Verfahren unspezifische Reaktionen. Die Reaktionen in den Extrakten waren dagegen eher spezifisch, jedoch extrem schwach. Daraus wird der Schluß gezogen, daß bei der Entstehung unspezifischer Reaktionen in faulendem Knochengewebe rein physikalische Bindungen von Antikörpern mit dem durch Fäulnis veränderten Knochenmaterial eine wesentliche Rolle spielen.
    Notizen: Summary Bone fragments were stored in water for 2 years at room temperature and investigated serologically using the following methods: Absorptionelution, extraction of blood group substances and immunohistochemistry (PAP). All 3 methods gave essentially specific results for fresh bone tissue but with putrid bone tissue unspecific reactions were found predominantly with the absorption-elution and PAP techniques. In contrast, more specific reactions were obtained from the extracts although they were much weaker. From this it can be concluded that pure physical binding plays a substantial role in the unspecific reaction between antibodies and bone material. It is suggested that the relevant physical properties are altered by putrifaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00202720
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  • 5
    Digitale Medien
    Digitale Medien
    Generation and application of a monoclonal antibody raised against a recombinant cytomegalovirus-specific polypeptide (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1003-1007 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Cytomegalovirus ; Procaryotic expression ; Recombinant antigen ; Phosphorylated protein pp150 ; Monoclonal antibody ; Immunofluorescence ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Procedures for diagnostics of cytomegalovirus infections include histopathology, cell culture, serology, and direct detection of viral antigens or nucleic acids within infected cells or tissues. In order to develop a new diagnostic reagent for viral antigen detection, we generated a mouse monoclonal antibody. This antibody was raised against a recombinant antigen representing part of the large phosphorylated structural protein pp150 of human cytomegalovirus. The monoclonal antibody was shown to be useful for antigen detection by immunofluorescence and immunoenzymatic staining in infected cells from cell culture as well as from infected organs. The antibody proved to be reactive even in paraffin-embedded sections from tissue specimens.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01646545
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  • 6
    Digitale Medien
    Digitale Medien
    Beitrag zur Erklärung unspezifischer serologischer Reaktionen in fauligem Knochengewebe (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 593-598 
    Details
    ISSN: 1437-1596
    Schlagwort(e): ABO in bones ; Putrification ; Extraction ; Immunohistochemistry ; ABO an Knochen ; Fäulnis ; Extraktion ; Immunhistochemie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Knochenteile wurden in Wasser bei Raumtemperatur 2 Jahre aufbewahrt und anschließend serologischen Untersuchungen unterzogen. Zur Anwendung kamen folgende Untersuchungsmethoden: Absorptions-Elutionstest, Extraktion von Blutgruppensubstanzen, Immunhistochemie (PAP). In frischen Knochen ergaben alle 3 Methoden im wesentlichen spezifische Ergebnisse. In faulen Knochenproben zeigten das Absorptions-Elutions-und das PAP-Verfahren unspezifische Reaktionen. Die Reaktionen in den Extrakten waren dagegen eher spezifisch, jedoch extrem schwach. Daraus wird der Schluß gezogen, daß bei der Entstehung unspezifischer Reaktionen in faulendem Knochengewebe rein physikalische Bindungen von Antikörpern mit dem durch Fäulnis veränderten Knochenmaterial eine wesentliche Rolle spielen.
    Notizen: Summary Bone fragments were stored in water for 2 years at room temperature and investigated serologically using the following methods: Absorptionelution, extraction of blood group substances and immunohistochemistry (PAP). All 3 methods gave essentially specific results for fresh bone tissue but with putrid bone tissue unspecific reactions were found predominantly with the absorption-elution and PAP techniques. In contrast, more specific reactions were obtained from the extracts although they were much weaker. From this it can be concluded that pure physical binding plays a substantial role in the unspecific reaction between antibodies and bone material. It is suggested that the relevant physical properties are altered by putrifaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01261424
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  • 7
    Digitale Medien
    Digitale Medien
    Immunohistochemical study of peptidergic nerves in infantile hypertrophic pyloric stenosis (1990)
    Springer
    Pediatric surgery international 5 (1990), S. 110-113 
    Details
    ISSN: 1437-9813
    Schlagwort(e): Infantile hypertrophic pyloric stenosis ; Enkephalin ; Substance P ; Vasoactive intestinal polypeptide ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In the recent literature it has been noted that peptidergic nerves may play an important role in infantile hypertrophic pyloric stenosis (HPS). Specimens from 20 patients with HPS were examined by immunohistochemistry with regard to the distribution of nerve cells and nerve fibers containing enkephalin (ENK), substance P (SP), and vasoactive intestinal polypeptide (VIP). Three subpopulations of peptides containing nerve cells and fibers were fairly numerous in the control specimens, but in the patients with HPS the density of the nerve fibers was markedly reduced and occasionally absent, especially the ENK- and VIP-containing fibers. In the myenteric plexus there was neither a reduction of nerve cell bodies nor of fibers. Our findings suggest that abnormalities of peptide-containing nerve fibers or impairment of neuronal function might results in HPS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00178228
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  • 8
    Digitale Medien
    Digitale Medien
    Magnetic resonance imaging of musculoaponeurotic fibromatosis (1990)
    Springer
    Skeletal radiology 19 (1990), S. 509-514 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Musculoaponeurotic fibromatosis ; Magnetic resonance imaging ; Gadolinium-DTPA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Musculoaponeurotic fibromatosis can be mistaken for soft-tissue sarcoma both clinically and on X-ray computed tomography. Magnetic resonance imaging (MRI) in three patients with this condition enabled the correct diagnosis to be made prospectively in two. The appearance on MRI of a heterogeneous mass with well-defined, predominantly peripheral areas of very low signal intensity due to dense fibrous tissue and areas of medium to high signal intensity corresponding to a more cellular stroma should raise the the suspicion of musculoaponeurotic fibromatosis. Cellular areas within the tumour showed moderate enhancement after gadolinium diethylene triamine pentaacetic acid administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00202700
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  • 9
    Digitale Medien
    Digitale Medien
    Cellular schwannoma (1990)
    Springer
    Virchows Archiv 416 (1990), S. 237-248 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Neurilemoma ; Pseudosarcoma ; Electron microscopy ; Immunohistochemistry ; Cytogenetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A series of 29 cellular schwannomas is described in terms of their clinical presentation and course, light and electron-microscopic appearance, immunohistochemical properties and cytogenetics. The study indicates that cellular schwannoma can be defined as a subtype of classical schwannoma, characterized by spindle cells forming a compact fascicular, sometimes fibrosarcoma-like growth pattern, a low mitotic activity, a generally moderate nuclear and cellular polymorphism and a high degree of Schwann cell differentiation as seen by electron microscopy and immunohistochemistry. The tumour is characteristically located close to the vertebral column, in the mediastinum or retroperitoneum and has a benign course. Occasionally bone destruction and neurological symptoms develop. The clinical appearance together with the high cellularity, fascicular pattern and mitotic activity had led to the erroneous diagnosis of a soft tissue sarcoma in a few cases, and cellular schwannoma may thus be considered to be a pseudosarcoma. Immunohistochemically, cellular schwannomas appear to deviate from classical schwannomas and malignant peripheral nerve sheath tumours by their expression of glial fibrillary acidic protein. The chromosome analysis revealed a normal diploid stemline karyotype, with a variety of abnormal clones, including one with monosomy 22.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01678983
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  • 10
    Digitale Medien
    Digitale Medien
    Anaplastic large cell lymphoma, CD30/Ki-1 positive, expressing the CD15/Leu-M1 antigen (1990)
    Springer
    Virchows Archiv 416 (1990), S. 229-235 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Anaplastic large cell lymphoma ; Non-Hodgkin's lymphoma ; Immunohistochemistry ; Antigen expression
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In this report we analyze the morphological and immunohistochemical findings observed in 5 cases of CD30/Ki-1 positive anaplastic large cell lymphoma, a recently recognized neoplastic entity. In comparison with the Ki-1 lymphomas so far described, these cases showed a fairly large number of Reed-Sternberg-like cells, often admixed with small lymphocytes and occasional eosinophils. Moreover, in all our cases immunohistochemical reactions detected the CD15/ Leu-M1 antigen, together with markers of the T-lineage and of lymphoid activation. In previous studies the CD15/Leu-M1 antigen has been found in the majority of cases of Hodgkin's disease, but has been stated to be absent typically in Ki-1 lymphomas. Our results indicate that this antigen cannot be considered a reliable tool to distinguish between Ki-1 lymphomas and Hodgkin's disease. Furthermore, the morphological and immunohistochemical findings reported suggest that in some cases Ki-1 cell lymphoma and Hodgkin's disease may be closely related. They may represent different steps in the progression of the same lymphoproliferative disorder.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01678982
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  • 11
    Digitale Medien
    Digitale Medien
    Malignant angioendotheliomatosis (Angiotropic lymphoma) of the gallbladder (1990)
    Springer
    Virchows Archiv 417 (1990), S. 243-246 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Gallbladder ; Malignant angioendotheliomatosis ; Malignant lymphoma ; Immunohistochemistry ; Differential diagnosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We present a case of malignant angioendotheliomatosis of the gallbladder, the first reported. Diagnostic problems connected with this rare malignancy are underlined. Immunohistochemical studies were useful in providing further evidence of the lymphoid nature of the neoplasm and avoiding possible misdiagnosis. We suggest that the term “angiotropic lymphoma” might be more appropriate to define this malignancy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600140
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  • 12
    Digitale Medien
    Digitale Medien
    Non-functional malignant paraganglioma of the stomach (1990)
    Springer
    Virchows Archiv 417 (1990), S. 261-266 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Stomach ; Paraganglioma ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report the second case of a malignant paraganglioma of the stomach in a 56-year-old female patient. However, our case is the first investigated by immunohistochemistry and electron-microscopy. The tumour was characterized immunohistochemically by the presence of neurofilament protein, glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, chromogranin A, ACTH, leu-enkephalin and vasoactive intestinal polypeptide, and ultrastructurally by demonstration of neurosecretory granules and paranuclear intermediate filament whorls. Despite massive metastatic spread in the abdominal cavity, the patient is still alive 4 years after initial diagnosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600143
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  • 13
    Digitale Medien
    Digitale Medien
    Immunohistochemical study of the abnormal cells in Langerhans cell histiocytosis (Histiocytosis x) (1990)
    Springer
    Virchows Archiv 416 (1990), S. 403-410 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Langerhans cell histiocytosis ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The immunophenotypic properties of the abnormal cells in routine specimens from 16 cases of Langerhans cell histiocytosis (LCH) were examined. In five cases, cryostat sections were also available. The abnormal cells expressed a similar phenotype and were positive for HLA-DR, S-100 protein, peanut agglutinin (PNA), CD1a, CD4 and several macrophage-associated markers, including CD11c, CDw32 and CD68 (the latter detectable in routine sections with antibody KP1). Staining with CD14, CD35 (C3b receptor), and CD11b (C3bi receptor) was negative with the exception of one of the cases in which a proportion of the cells showed faint positivity with CD11b. Staining for pan-T-cell (CD2, CD3, CD5) and panB-cell (CD 19, CD22) antigens was negative in all lesions. It is concluded that LCH expresses a characteristic phenotype with some heterogeneity with regard to macrophage markers and that immunohistochemical methods in cryostat sections and routine specimens form a useful supplement to other techniques for the diagnosis of this condition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605145
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  • 14
    Digitale Medien
    Digitale Medien
    The spleen in osteomyelofibrosis (1990)
    Springer
    Virchows Archiv 416 (1990), S. 437-442 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Hematopoiesis ; Immunohistochemistry ; Osteomyelofibrosis ; Spleen
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 30 spleens from patients with biopsy proven primary osteomyelofibrosis were studied by histological and immunohistochemical methods. The presence of trilinear haematopoiesis along the splenic circulatory pathway supports the theory that the spleen acquires haematopoietic precursor cells by filtration of the peripheral blood. In addition, impairment of intrasplenic circulation with subsequent red pulp congestion, pulp cord fibrosis and haemophagocytosis is of importance for the pathogenesis of both marked splenic haematopoiesis and complications due to hypersplenism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605150
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  • 15
    Digitale Medien
    Digitale Medien
    Solid-cystic tumour of the pancreas (1990)
    Springer
    Virchows Archiv 416 (1990), S. 535-538 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Pancreatic tumour ; Immunohistochemistry ; Flow cytometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Immunohistochemical studies and DNA flow-cytometric investigations were performed in a case of solid-cystic tumour of the pancreas in a 35-year-old woman. All tumour cells were immunoreactive for the neuroendocrine cell markers chromogranin A and neuron-specificγ-enolase. Moreover, about 10% of tumour cells were immunoreactive for insulin, while hypoglycaemia was absent. Few tumour cells (less than 1%) were immunoreactive for somatostatin, and no cells were found to be immunoreactive for pancreatic polypeptide or glucagon. No immunoreactivity was present for duct cell marker carcino-embryonic antigen and only individual cells were reactive forα 1-antitrypsin. Nuclear DNA content of the tumour cells was diploid and the proliferative activity was low. In confirmation of some reports on neuroendocrine markers in solid-cystic tumour of the pancreas, our findings support the theory that the lesion is a hormonally inactive neuroendocrine pancreatic tumour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600305
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  • 16
    Digitale Medien
    Digitale Medien
    Diagnosis of primary cerebral lymphoma with particular reference to CT-guided stereotactic biopsy (1990)
    Springer
    Virchows Archiv 417 (1990), S. 21-28 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Non-Hodgkin's lymphoma ; Brain neoplasm ; Stereotactic brain biopsy ; Histological diagnosis ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In establishing the histological diagnosis of primary cerebral lymphoma, stereotactic brain tumour biopsy is the method of choice as the mainstay of therapy is radiation and chemotherapy. This study describes the histopathology and diagnostic immunohistochemistry of 54 primary brain lymphomas in a mainly non-AIDS population. The stereotactic biopsies were performed using the Leksell CT stereotactic frame and a spiral needle which procured about 10-mm-long tissue cylinders. Usually, three successive biopsy cylinders were taken along the target trajectory. Histological examination revealed the prevalence of high-grade non-Hodgkin's lymphoma of the polymorphous centroblastic type. The series did not include any low-grade lymphomas or T-cell lymphomas. L-26 immunohistochemistry resulted in a positive staining of the blasts, thus confirming the B-cell origin of primary brain lymphomas. Small reactive T-lymphocytes and monohistiocytic cells were also found within and at the periphery of the lymphomas and in areas of degeneration. In the biopsies of nine patients, who had shown significant reduction of the lesions on the CT scans, after corticosteroid medication, regressive tissue changes were predominant and consisted of T-lymphocytes, macrophages, and occasionally bizarre reactive astrocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600105
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  • 17
    Digitale Medien
    Digitale Medien
    Relationships among expression, transcription and rearrangement of T-cell receptor Β gene in T-cell lymphomas (1990)
    Springer
    Virchows Archiv 417 (1990), S. 57-65 
    Details
    ISSN: 1432-2307
    Schlagwort(e): T-cell receptors ; Malignant lymphomas ; Immunohistochemistry ; Transcription ; Rearrangement
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The expression of T-cell receptors (TCR) in malignant lymphomas was examined immunohistochemically by monoclonal antibodies which react with the TCRΒ or TCRδ chain. TCRΒ was expressed in 16 out of 47 non-Hodgkin's lymphomas. These included 15 T-cell lymphomas and 1 Ki-1 lymphoma. The anti-TCRΒ chain antibody,ΒF1, did not react with 26 B-cell lymphomas, 1 Ki-1 lymphoma or 6 Hodgkin's disease. The anti-TCRδ chain antibody, TCRδ1, did not react with any type of malignant lymphoma. Although TCRΒ and CD3 were co-expressed in normal lymphoid tissues and most T-cell lymphomas, 3 cases of CD3+CD4+ CD8−T-cell lymphoma failed to express TCR0. TCRΒ and Ig JH gene configurations in malignant lymphomas were examined by Southern hybridization. Although each of 9 T-cell lymphomas had a rearranged TCRΒ locus, TCRΒ gene rearrangement in the 3 cases ofΒF1−CD3+T-cell lymphomas was demonstrated by Southern blot. No transcripts of the TCRΒ gene could be found in 2 out of the 3ΒF1−CD3+T-cell lymphomas by Northern blot, indicating the lack of TCRΒ protein expression to be due to non-transcription of the TCR gene. Loss of TCRΒ proteins in these T-cell lymphomas is thus quite likely to be associated with T-cell tumour activation and progression, since 3ΒF1−CD3+T-cell lymphomas expressed CD25 (interleukin-2 receptor) to a high degree.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600110
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  • 18
    Digitale Medien
    Digitale Medien
    So-called minute chemodectoma of the lung (1990)
    Springer
    Virchows Archiv 417 (1990), S. 113-118 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Minute chemodectoma ; Lung ; Ultrastructure ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary So-called minute pulmonary chemodectoma is a curious, small lung tumour found mainly in women. The nature and origin of the proliferating cells are still obscure. In the first report on the tumour, the component cells were described as resembling chemoreceptor cells and the tumour was named chemodectoma. However, electron microscopic studies of the tumour have revealed no evidence of neuronal characteristics and have shown a close resemblance to meningothelial cells. In this study, the electron microscopic findings were similar to those previously reported but in one of the two cases, tumour cells were filled with abundant cytofilaments, giving them an occasional dense, patch-like appearance. Immunostaining for myosin and vimentin was positive in all tumour cells, but epithelial membrane antigen staining was not seen. These findings indicate that the tumour might have its origin from muscle cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02190528
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  • 19
    Digitale Medien
    Digitale Medien
    Immunohistological study on collagenous proteins of benign and malignant human cartilaginous tumours of bone (1990)
    Springer
    Virchows Archiv 417 (1990), S. 291-297 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Chondrosarcoma ; Chondroma ; Collagen ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The immunohistological distribution of collagen types I, II, III, V and VI in human benign and malignant cartilaginous tumours of bone was examined with regard to their aggressiveness. The matrix of enchondromas consisted of type II collagen distributed diffusely, and type VI predominantly localized in the immediate surroundings of the cells. Types I, III and V collagen were not found. These findings were similar to the distribution of collagenous proteins in normal hyaline cartilage where each lobule was consistently rimmed by types I and V collagen. In grade 1 chondrosarcomas, the main collagenous components of matrix were also types II and VI collagen. Type II was sometimes found in the cytoplasm of tumour cells and type VI tended to lose territorial localization. In addition, type I collagen was demonstrated consistently and type V in some cases. In grade 2 chondrosarcomas, type II collagen was demonstrated not only in the matrix but occasionally in the cytoplasm of tumour cells. Type VI was dispersed in the intercellular areas. The other collagenous proteins such as types I, III and V were also present in the matrix. In grade 3 chondrosarcomas, type II collagen was localized predominantly in the cytoplasm of tumour cells and in the adjacent matrix. Type VI was markedly decreased with complete loss of pericellular distribution, whereas types I, III and V were constantly present in the matrix. Those alterations in the distribution of collagen types correlated well with the aggressive behaviour of the tumours. The findings suggest that distribution of different collagen types in cartilaginous tumours reflects the immaturity of the tumour cells and is a useful indicator of their aggressiveness.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605779
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  • 20
    Digitale Medien
    Digitale Medien
    Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle (1990)
    Springer
    Virchows Archiv 417 (1990), S. 369-375 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Oestrogen receptor ; Progesterone receptor ; Human ovary ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Immunohistochemistry was used to determine the distribution of oestrogen receptors (ER) and progesterone receptors (PR) in the human ovary during folliculogenesis. Primordial and preantral follicles did not contain ER or PR. The granulosa cells of antral follicles had ER, but negligible PR, before the LH surge. In contrast, at the time of LH surge, these cells of the dominant follicle contained PR, but not ER. On the other hand, granulosa cells of the non-dominant follicles had ER, but not PR. After ovulation, the PR persisted in the luteinized granulosa cells and in the corpus luteum during early pregnancy. The theca interna and surrounding stromal cells were ER-negative and PR-positive throughout the menstrual cycle. Thus, the results show that ER and PR are not expressed simultaneously in the granulosa cells, the thecal cells, or the stromal cells during folliculogenesis. Mechanisms controlling the expression of steroid receptors during the normal menstrual cycle and in early pregnancy are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01606025
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  • 21
    Digitale Medien
    Digitale Medien
    3D visualization of tomographic volume data using the generalized voxel model (1990)
    Springer
    The visual computer 6 (1990), S. 28-36 
    Details
    ISSN: 1432-2315
    Schlagwort(e): Computer tomography ; Magnetic resonance imaging ; Ray-casting algorithm ; Voxel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract Multi-slice images obtained from computer tomography and magnetic resonance imaging represent a 3D image volume. For its visualization we use a raycasting algorithm working on a gray-scale voxel data model. This model is extended by additional attributes such as membership to an organ or a second imaging modality (“generalized voxel model”). It is shown that the combination of different surface-rendering algorithms together with cutting and transparent display allow a realistic visualization of the human anatomy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01902627
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  • 22
    Digitale Medien
    Digitale Medien
    Pancreatoblastoma with marked elevation of serum alpha-fetoprotein (1990)
    Springer
    Virchows Archiv 416 (1990), S. 265-270 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Pancreatic neoplasm ; Glandular epithelial neoplasm ; Child ; Alpha ; fetoprotein ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The autopsy findings in a pancreatoblastoma in a 7-year-old Japanese girl is reported. The tumour was in the head and body of the pancreas, and was associated with diffuse carcinomatous peritonitis and hepatic and pulmonary metastases. There was marked elevation (more than 10000 ng/ml) of serum alpha-fetoprotein (AFP). Histopathologically the tumour was composed of solid epithelial elements with fibrous stroma, showing acinar arrangement, squamoid clusters and tubular structures. The epithelial elements contained numerous fine PAS positive granules in the cytoplasm. Immunocytochemical results suggested epithelial differentiation with positivity to alpha-1-antitrypsin (AAT), keratin, CA19-9, and AFP. No endocrine elements were recognized. Characteristic feature of this tumour are discussed and compared with prevoius reports.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01678986
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  • 23
    Digitale Medien
    Digitale Medien
    Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions (1990)
    Springer
    Virchows Archiv 416 (1990), S. 375-382 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Myofibroblast ; Cytoskeleton ; Desmoid tumour ; Desmin ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The characteristics of the cytoskeleton of myofibroblasts were examined immunohistochemically in 10 extra-abdominal desmoid tumours, 3 palmar and 2 plantar fibromatoses and 5 nodular fasciites; in the cultured cells of one desmoid tumour, and also ultrastructurally in 3 desmoid tumours. Polyclonal anti-desmin antibody reacted with the cells in 7 extra-abdominal desmoid tumours, 1 palmar fibromatosis, 1 plantar fibromatosis and 3 nodular fasciites. Monoclonal antidesmin antibody reacted with cells in only 2 desmoid tumours. Desmin-positive spindle cells were scattered throughout these lesions. There were no marked ultrastructural differences between desmin-positive and desmin-negative desmoids. All specimens except one specimen of nodular fasciitis showed immunoreactivity for alpha-smooth muscle actin and vimentin. Muscle actin-positive cells were observed in all specimens. Cultured cells gave positive reactions with polyclonal desmin antibody as well as to vimentin antibodies and two preparations of actin antibodies, whereas the original tumour did not react with desmin antibody. The present studies suggested that the cytoskeleton of some myofibroblasts in both neoplastic and reactive lesions resembles that of smooth muscle cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605141
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  • 24
    Digitale Medien
    Digitale Medien
    Complementary expression of melanosomal antigens and constant expression of pigment-independent antigen during the evolution of melanocytic tumours (1990)
    Springer
    Virchows Archiv 416 (1990), S. 513-519 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Monoclonal antibody ; Tyrosinase ; Malignant melanoma ; Metastasis ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have generated monoclonal antibodies (MoAbs) against melanosomal proteins (MoAb 1C11 and MoAb HMSA-1) and a cytoplasmic protein strongly synthesized in neoplastic melanocytes but not associated with melanogenesis (MoAb 7H11). An immunohistochemical study of paraffin sections showed that nearly 90% of epidermal neoplastic melanocytes, including melanomas, expressed 1C11 antigen, whereas this antigen was poorly preserved in dermal melanocytic cells except melanomas. HMSA-1 antigen was expressed in a complementary manner to 1C11 antigen, being found in dermal naevus cells but not generally in the epidermal regions, except for dysplastic naevi and melanomas. In contrast, 7H11 antigen was distributed in nearly 90% of melanocytic tumours except solar lentigo and lentigo maligna lesions. The failure of MoAb 1C11 to react with dermal melanocytes may reflect a subtle alteration in melanogenesis during tumour evolution. Overall, the combined use of MoAbs serves as an accurate diagnosis of melanocytic tumours, the pigment-independent MoAb 7H11 being particularly useful for amelanotic and metastatic lesions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600302
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  • 25
    Digitale Medien
    Digitale Medien
    Immunohistochemical study of possible changes in keratin expression during neoplastic transformation of the uterine mucosa (1990)
    Springer
    Virchows Archiv 416 (1990), S. 287-293 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Cervix ; Endometrium ; Keratins ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present study aimed to examine possible changes in keratin expression during neoplastic transformation of the uterine mucosa and possible differences in keratin expression between endocervical and endometrial adenocarcinomas. Routinely processed specimens with normal morphology or neoplastic changes were stained immunohistochemically using 5 commercial antibodies to keratinfilaments of molecular weight 39–58 kD: CAM 5.2, RCK 102, MCA 144, PKE and PRE. We generally found a change in keratin expression during the neoplastic transformation, consisting of pronounced heterogeneity compared with normal epithelia. In distinguishing koilocytic atypia from CIN, RCK 102 (52.5, 58 Kd) may prove helpful as it stains neoplastic cells strongly and shows no reaction in koilocytes. Staining with the antibody CAM 5.2 (reactive with 39, 43, 50 kD filaments) may aid in distinguishing between cervical and endometrial adenocarcinomas. The former is stained uniformly; the latter shows a more variable staining.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605289
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  • 26
    Digitale Medien
    Digitale Medien
    Amyloid in intervertebral discs of surgery and autopsy material (1990)
    Springer
    Virchows Archiv 416 (1990), S. 335-341 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Amyloidosis ; Immunohistochemistry ; Intervertebral disc
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Intervertebral discs from 82 consecutive operations on herniation and 59 autopsies (one case with generalized amyloidosis) were studied. Amyloid deposits observed in surgical and autopsy specimens increased with age in both series. Degenerative changes were related to age and to amyloid deposits in autopsy, but not in surgical cases. Calcium pyrophosphate dihydrate deposits (often in proximity to amyloid deposits) were found in autopsy discs of six patients and in surgical specimens of three patients with previous operations on herniated discs. Antisera against amyloid fibril proteins of different types including AA-, Aλ-, Aκ, AF- and AB-types showed no reaction with disc amyloid. In one case with generalized Aλ-amyloidosis the disc amyloid was not of the Aλ-type. Based on our results, we suppose that disc amyloid is a form of localized senile amyloidosis — possibly representing a new class of amyloid limited to cartilage tissue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605294
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  • 27
    Digitale Medien
    Digitale Medien
    Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material (1990)
    Springer
    Virchows Archiv 416 (1990), S. 351-355 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Granulocytic sarcoma ; Immunohistochemistry ; Naphthol ASD chloroacetate reaction ; Nasal region ; Malignant lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A panel of monoclonal antibodies (anti-CD45 [common leukocyte antigen], Ki-B3, L26, MT1, UCHL1, anti-CD15 [X-hapten], anti-neutrophil granule protein elastase [NP57]), anti-lysozyme, and the naphthol-ASD-chloroacetate reaction were applied to two cases of granulocytic sarcoma (GS) for evaluation of their utility in differentiating GS from malignant lymphoma. Lysozyme and naphthol-ASD-chloroacetate esterase were found to be the most reliable markers for detection of the myeloid nature of the tumour cells. GS infiltrated solely the mucosa of the nasal cavity in one case, while in the other it involved both the nasal cavity and maxillary sinus with simultaneous eruptions on the skin of the trunk. In both cases, peripheral blood and bone marrow findings were inconspicuous at the time of diagnosis of GS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605296
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  • 28
    Digitale Medien
    Digitale Medien
    Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries (1990)
    Springer
    Virchows Archiv 417 (1990), S. 105-111 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Arteriosclerosis ; Lipoprotein(a) ; Apoprotein (a) ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Lipoprotein(a), as an atherogenic particle, represents an independent risk factor for coronary heart disease. In the present study the morphological distribution of apoprotein (a) and apoprotein B within the arterial wall is described. Apoprotein B, a constituent of very low-density lipoprotein, low-density lipoprotein and lipoprotein(a) has previously been demonstrated in atheromatous lesions. Lipoprotein(a) possesses an additional protein, designated apoprotein (a). Autopsy material (n=74) from the left coronary artery and from the thoracic aorta has been examined by means of immunohistochemistry and both apoprotein (a) and apoprotein B were detected, primarily associated with the extracellular matrix and accumulating in lesions in the arterial wall. The staining pattern for both antigens was almost always found to be congruent, suggesting that the detection of (a)-antigen has to be attributed at least in part to the presence of lipoprotein(a). It is concluded that both low-density lipoprotein and lipoprotein(a) have an important role in the pathogenesis of atherosclerosis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02190527
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  • 29
    Digitale Medien
    Digitale Medien
    Skin deposits in hereditary cystatin C amyloidosis (1990)
    Springer
    Virchows Archiv 417 (1990), S. 325-331 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Hereditary disease ; Amyloidosis ; Skin ; Cysteine proteinase inhibitor ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Clinically normal skin from 47 individuals aged 9–70 years was investigated. Cystatin C amyloid deposits were found in various locations of the skin by light and/or electron microscopy, in all 12 patients with a clinical history of hereditary cystatin C amyloidosis (HCCA). Six asymptomatic individuals, who had the Alu 1 restriction fragment length polymorphism (RFLP) marker reported to cosegregate with the disease, also had cystatin C amyloid deposits in the skin. Three asymptomatic individuals (age 17–46) belonging to the HCCA families were without amyloid in the skin but had Alu 1 RFLP marker. Skin from 12 individuals who served as controls and skin from 14 close relatives of the patients was negative for amyloid. Punch biopsy of the skin is a simple procedure which is of value for the diagnosis of HCCA, even before the appearance of clinical symptoms. This method might also be of use in following progression of the disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605784
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  • 30
    Digitale Medien
    Digitale Medien
    Insulin therapy prevents spontaneous recovery from streptozotocin-induced diabetes in Syrian hamsters (1990)
    Springer
    Virchows Archiv 417 (1990), S. 333-341 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Streptozotocin ; Diabetes ; Syrian hamsters ; Autoradiography ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Streptozotocin (Sz) given as a single dose of 50 mg/kg body wt. caused severe diabetes in Syrian hamsters. However, the level of blood glucose decreased gradually after 21 days post-Sz and reached the near normal level at 70 days in 90% of hamsters. The recovery from diabetes was associated with the regeneration of theβ-cells of islets and a reduction in the initially increased number ofα- andδ-cells. Daily treatment of diabetic hamsters with insulin was associated with the persistence of severe diabetes, lack of or minimal tendency forβ-cell regeneration and sustained hyperplasia ofα- andδ-cells in 90% of hamsters. Insulin also inhibited DNA synthesis (as measured by incorporation of tritiated thymidine), in ductal, ductular and acinar cells in Sz-pretreated hamsters but not in normoglycemic control hamsters treated with insulin alone. The results demonstrate a deleterious effect of exogenous insulin in the course of Sz-induced diabetes in hamsters.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605785
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  • 31
    Digitale Medien
    Digitale Medien
    Immunoreactive luteinizing hormone in functioning corticotroph adenomas of the pituitary (1990)
    Springer
    Virchows Archiv 417 (1990), S. 361-367 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Corticotroph adenoma ; Adrenocorticotropin ; Luteinizing hormone ; Immunohistochemistry ; Tissue culture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two pituitary adenomas removed from a 37-year-old woman and a 26-year-old woman with typical Cushing's disease were studied by light and electron microscopy, immunohistochemistry and radioimmunoassay of tissue culture media. Both patients had high plasma levels of cortisol and normal levels of luteinizing hormone (LH). Both tumours were monomorphous, composed of densely granulated corticotrophs; the tumour cells contained periodic acid-Schiff positivity, were arranged in a sinusoidal pattern and, ultrastructurally, contained well-developed cytoplasmic organelles. By immunohistochemistry the majority of tumour cells contained immunoreactive adrenocorticotropin (ACTH); approximately 10% of the tumour cell population contained LH immunoreactivity. The LH-positive cells tended to form clusters scattered widely throughout the tumour tissues. LH immunoreactivity was demonstrated in some ACTH-immunoreactive cells on serial sections. Large amounts of immunoreactive ACTH and smaller quantities of LH, follicle stimulating hormone and αsubunit were released into the culture media and release of the glycoprotein hormones responded in parallel to corticotropin releasing hormone stimulation or inhibition by cortisol. These findings indicate that LH can be simultaneously produced and released by ACTH-producing tumour cells of otherwise typical functioning corticotroph adenomas. The capacity for LH production may be acquired during neoplastic proliferation. This is the first detailed report of concurrent production of LH by pituitary corticotroph adenomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01605790
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  • 32
    Digitale Medien
    Digitale Medien
    Variation of prostate-specific antigen expression in different tumour growth patterns present in prostatectomy specimens (1990)
    Springer
    Urological research 18 (1990), S. 181-187 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Prostatic carcinoma ; Prostate-specific antigen ; Prostate-specific acid phosphatase ; Immunohistochemistry ; Differential expression ; Tumour architecture
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A series of 55 randomly chosen radical prostatectomy specimens was analyzed for expression of prostate-specific antigen (PSA) by immunohistochemical techniques. Tissue sections were selected in such a manner that in addition to glandular benign prostatic hyperplasia (BPH), one or more different prostatic tumour growth patterns were present. Four monoclonal antibodies, directed against three different PSA epitopes, and one polyclonal anti-PSA antiserum were used. Expression of PSA was compared with that of prostate-specific acid phosphatase (PAP), recognized by two different polyclonal antisera. A critical dilution aimed at a maximum of staining intensity on BPH tissue sections was chosen for all antibodies. Anti-PSA and anti-PAP antisera stained essentially all BPH samples (over 90%). Irrespective of the nature of the antibodies used, PSA expression was found to be decreased in prostatic carcinoma. A clear cut relationship was found between immunoreactivity for PSA and the degree of differentiation of the tumour area. Under the experimental conditions used the PSA monoclonal antibodies stained only 1 out of 10 undifferentiated carcinomas, whereas 50% to 70% of the well- and moderately-differentiated carcinomas showed immunoreactivity. This correlation was less pronounced with the PAP staining pattern. If the PSA antibody titer was raised the percentage of clearly staining undifferentiated carcinomas could be considerably increased (up to 60%–100%), indicating that PSA expression is not absent, but lowered in most (if not all) undifferentiated carcinomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00295844
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  • 33
    Digitale Medien
    Digitale Medien
    Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 581-583 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Parkinson's disease ; Lewy body ; Enteric nervous system ; Immunohistochemistry ; Vasoactive intestinal polypeptide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We performed immunohistochemical analysis of specimens from three autopsied patients with Parkinson's disease, using antibodies to tyrosine hydroxylase (TH), vasoactive intestinal polypeptide (VIP), somatostatin, met-enkephalin, leu-enkephalin and substance P in an attempt to reveal the types of neurons that contain Lewy bodies (LBs) in the paravertebral and celiac sympathetic ganglia and in the enteric nervous system of the alimentary tract. In the sympathetic ganglia, almost all LB-containing neuronal cell bodies and processes were immunoreactive for TH. In the alimentary tract, however, most LBs were found in the VIP-immunoreactive (VIP-IR) neuronal cell bodies and processes. In spite of the significant presence of TH-IR neuronal cell bodies and processes in the alimentary tract, LB-containing TH-IR neuronal elements were rarely encountered. These findings indicate that in the alimentary tract, the VIP neuron system is mainly involved in the disease process of Parkinson's disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294234
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  • 34
    Digitale Medien
    Digitale Medien
    Creatine kinase isozyme expression in prenatal rat heart (1990)
    Springer
    Anatomy and embryology 182 (1990), S. 195-203 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Creatine kinase ; Development ; Distribution ; Rat ; Heart ; Muscle ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution pattern of creatine kinase (E.C 2.7.3.2) isozymes in prenatal rat heart and skeletal muscle was studied by immunohistochemistry. Between embryonic day (ED) 12–18, creatine kinase M (CK-M) is heterogeneously expressed in the heart: a pronounced staining of CK-M is first observed in the outflow tract and the trabeculae of the right ventricle (ED12-14), and subsequently in the venous valves, the interatrial septum and the sinoatrial node. From ED18 onwards, a homogeneous expression of CK-M is observed due to an increase in isozyme concentration in the remaining part of the myocardium. By contrast, the developmental appearance of creatine kinase B (CK-B) occurs almost homogeneously throughout the heart between ED11-14. Thereafter, a decrease of the CK-B is first observed in the inflow tract (in particular in the sinoatrial node), in the inner part of those atrial walls that are adjacent to the atrioventricular junction, and temporarily in a band in the upper part of the interventricular septum. From ED18, a selective disappearance of CK-B is found in the papillary muscle of the left ventricle. At birth, a considerable amount of CK-B remains present in the ventricular walls. Although some of the stage-dependent regional differences in expression of the creatine kinase isozymes, in particular those of the M-subunit, are shared by other mammalian and avian species, their significance for the developmental changes in the physiology of the heart is speculative at present.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00174018
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  • 35
    Digitale Medien
    Digitale Medien
    Asymmetric distribution of calbindin-D28K in the ganglia habenulae of an elasmobranch fish (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 389-391 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Calbindin-D28K ; Immunohistochemistry ; Habenular ganglia ; Elasmobranchs ; Scyliorhinus canicula
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Using an antibody raised against a purified chick duodenal vitamin D-dependent calcium-binding protein, the presence and distribution of calbindin has been studied immunohistochemically in the habenular ganglia of the dogfish. In the more developed left ganglion, a positive reaction was clearly observed in the neurons of the medial nucleus, whereas in the lateral nucleus, only some scarce, hardly immunostained cells appeared. In the neurons of the right habenula however, no immuno-reactivity was observed. The distribution of vitamin D-dependent calcium-binding protein in the dogfish habenulae is therefore asymmetrical. This may be due to differences in the neuronal activity between the two ganglia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186911
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  • 36
    Digitale Medien
    Digitale Medien
    Rebound of ICP after brain compression (1990)
    Springer
    Acta neurochirurgica 104 (1990), S. 126-135 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Magnetic resonance imaging ; intracranial mass lesion ; intracranial pressure rebound ; brain oedema
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The rebound of intracranial pressure (ICP) occurring after decompression of an intracranial mass lesion was studied in an epidural balloon compression model. Intracranial morphology and brain tissue water content were assessed with magnetic resonance imaging (MRI). Fast and slow components of the transverse relaxation time (T2) were used as indicators of brain oedema development. During balloon compression a progressive prolongation of both the fast and the slow T2 components took place. Following deflation of the balloon both components increased rapidly, particularly the slow-T2. The MR scans displayed progressive occlusion of the aqueduct, and obliteration of the ambient and pontine cisterns. The changes in morphology and in water content after decompression had largely the same time course as the development of the rebound of ICP. In contrast, no changes in morphology and tissue water content occurred after hydrostatic brain compression achieved by subarachnoid fluid infusion. The findings suggest that the intracranial pressure rebound is caused by cerebral oedema accumulated during and particularly in the recirculation phase after an ischaemic injury of adequate intensity and adequate duration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01842830
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  • 37
    Digitale Medien
    Digitale Medien
    Pattern of neuronal vulnerability in the cat hippocampus after one hour of global cerebral ischemia (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 444-455 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Ischemia ; Cat ; Selective vulnerability ; Immunohistochemistry ; Glial fibrillary acidic protein (GFAP)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The dorsal hippocampus of cat was investigated by light microscopy and immunohistochemistry following 1 h global cerebral ischemia and various recirculation times from 1 day to 1 year. Complete ischemia was produced by combining hypotension with intrathoracic occlusion of major arteries. Postischemic resuscitation was carried out using an intensive care regimen with continuous neurophysiological monitoring. Brains of controls (n=4) and postischemic animals (n=12) were fixed in formaldehyde and prepared for histology and immunohistochemistry of glial fibrillary acidic protein (GFAP). In all post-ischemic animals the hilus and the regio superior of dorsal hippocampus which encompasses the CA1 subfield were severely damaged. Neurons in these regions exhibited the typical sequela of neuronal death. GFAP staining revealed vivid astroglial proliferation in stratum lacunosum-moleculare and stratum oriens. Changes in the regio inferior of dorsal hippocampus, i.e., CA3 subfield, and in dentate gyrus granular layer, were variable. Although most animals exhibited moderate to severe neuronal and glial alterations, groups of surviving cells were observed in the stratum oriens and in the granular layer of dentate gyrus. In one animal the majority of CA3 pyramidal cells and granule cells was preserved. These findings demonstrate that after 1 h of complete cerebral ischemia dorsal hippocampus exhibits two different types of injury: a consistent pattern of selective vulnerability in the hilus and the regio superior, and a variable pattern of non-selective injury in the regio inferior and dentate gyrus. The two patterns can be best explained by intrinsic (pathoclitic) and extrinsic (hemodynamic/edema) factors, respectively and are likely to represent basically different mechanisms of ischemic injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308722
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  • 38
    Digitale Medien
    Digitale Medien
    Increased 5-hydroxytryptamine immunoreactivity in traumatized spinal cord (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 12-17 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Serotonin (5-hydroxytryptamine, 5-HT) ; Spinal cord trauma ; Ventral horn ; p-Chlorophenyl alanine ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The possibility that serotonin (5-hydroxytryptamine, 5-HT) is involved in the early tissue reactions occurring in spinal cord trauma was examined in a rat model using an immunocytochemical technique. The injury was made in the form of a 5-mm long and 2.5-mm wide lesion of the right dorsal horn at the level of T10–11. Injured rats, pretreated with the 5-HT synthesis blocking agent, p-chlorophenyl alanine (p-CPA) were compared with untreated injured controls and the animals were allowed to survive for 5 h. The distribution of 5-HT was examined in proximal and distal cross-sections of the cord, located 2 and 5 mm away from the injury. Normal rats showed immunoreactive material in nerve cell processes and in a few nerve cell bodies of the ventral horns. The trauma to the spinal cord caused a marked increase in 5-HT immunoreactivity in the segments located 2 mm proximal and distal to the injury, particularly in the ipsilateral ventral horn. The segment located 5 mm distal to the lesion showed a similar increase in immunoreactivity but it was apparently less pronounced in the corresponding proximal segment. Treatment with p-CPA markedly reduced the trauma-induced increase in 5-HT immunoreactivity in all the segments. These immunohistochemical findings were in line with the changes in the contents of 5-HT measured biochemically in corresponding spinal cord segments. At the onset of the trauma to the spinal cord 5-HT is thus present in the tissue, mainly in the form of 5-HT-containing nerve cell processes. Biochemical determinations also revealed that there is an increased amount of 5-HT in the traumatized spinal cord. The present study indicates that this is at least partly due to an increased amount of 5-HT in neurons and nerve cell processes of the perifocal region. The pathophysiollogical significance of the observed 5-HT-reaction in spinal cord injury is not known in all its details. However, 5-HT might be implicated in such tissue reaction, such as increased microvascular permea bility and edema formation occurring in the early period after trauma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294216
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  • 39
    Digitale Medien
    Digitale Medien
    Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 393-400 
    Details
    ISSN: 1432-0533
    Schlagwort(e): AIDS ; Immunohistochemistry ; gp41 ; Microglia ; Distribution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Among 100 brains from patients with acquired immunodeficiency syndrome (AIDS), 33 brains (21 adults and 12 children) with histological evidence of subacute AIDS encephalitis were immunostained with one of the most sensitive antibodies to HIV-1 antigen, anti-gp41. Twenty-six (20/21 adults, 6/12 children) of the 33 brains showed pg41 positivity. Brains from children had fewer gp41-positive cells than brains from adults. The distribution of gp41-positive cells was characteristic. They were frequently detected and most numerous in the globus pallidus (medial 〉 lateral). Although gp41-positive cells were prevalent, fewer were detected in the corpus striatum and thalamus. Of infratentorial areas involved, the ventral midbrain, especially the substantia nigra, and the dentate nucleus contained many positive cells. Lower levels of infections, often patchy, were noted in the cerebral and cerebellar white matter and pontine base. Gp41-positive cells were rarely seen in the cerebral cortex, medulla, spinal cord, leptomeninges, choroid plexus, ependyma, subependymal areas and endothelia. Besides immunoreactive macrophages and multinucleated cells, gp41-positive microglia with various morphological alterations were abundant in the deep cerebral gray matter, ventral midbrain and dentate nucleus. Most of these microglia were undetectable with conventional histological methods. We discuss the significance of the distribution of HIV-1-infected cells, especially microglia, with respect to cellular tropism and involvement of deep gray matter nuclei in a pattern reminiscent of a multisystem atrophy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00307693
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  • 40
    Digitale Medien
    Digitale Medien
    Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibers: immunocytochemical and fine structural studies, with a note on unusual 18- to 20-nm filaments (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 406-414 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Cytoplasmic body myopathy ; Immunohistochemistry ; Desmin ; Intermediate filaments ; Actin filaments
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a fine structural and immunocytochemical study, the latter performed on semithin sections of epoxy resin embedded skeletal muscle fibers, three types of cytoplasmic bodies were identified in a case of cytoplasmic body myopathy: (1) The first type, the classical type, showed a central core and a light halo with radiating actin filaments at the periphery. (2) The second type, the spheroid body was characterized by irregularly arranged granular masses associated with intermediate filaments. Desmin immunoreactivity occurred in the central and peripheral parts, where filaments of intermediate size were visualized by electron microscopy. Desmin immunoreactivity was noted also at the Z-bands of striated annulets, within areas of disordered myofibrils, such as sarcoplasmic masses, and in atrophic muscle fibers. (3) The third type of the cytoplasmic body was composed mainly of large masses of uneven granularity and electron density. The center of this type reacted to anti-actin antibody suggesting that the 5- to 6-nm filaments, which ultrastructurally proved to be a major component, were of the actin type. By contrast, neither intermediate filaments nor actin microfilaments were found by electron microscopy in cytoplasmic bodies in a second case where no immunoreaction to desmin or actin occurred. Anti-vimentin antibody stained only the cytoplasm of endomysial cells, but not the inclusion bodies. Some other, unusual inclusions with 18- to 20-nm tubulo-filamentous structures have to be distinguished from the various types of filaments in cytoplasmic bodies. It is concluded, that pleomorphism and heterogeneity of “cytoplasmic bodies” have to be taken into consideration when classifying cytoplasmic body myopathies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00307695
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  • 41
    Digitale Medien
    Digitale Medien
    Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 453-458 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Dementia ; Neuronal inclusions ; Pick's disease ; Lewy bodies ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 62-year-old man presented with memory impairment progressing over 6 years to dementia with near mutism and was diagnosed as having Alzheimer's disease. At autopsy his brain showed lobar atrophy suggestive of Pick's disease and there were spherical intracytoplasmic neuronal inclusions in the fascia dentata, hippocampal pyramidal cell layer, and temporal cortex. Unlike Pick bodies, however, the inclusions were eosinophilic with H&E stains, non-argyrophilic, and failed to react immunohistochemically with antibodies to paired helical filaments or Alz-50. They did label with antibodies to ubiquitin, however, and electron microscopy disclosed dense-cored granular structures with thin filamentous coronas which resembled brain stem-type Lewy bodies. The substantia nigra and locus coeruleus were not affected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00307702
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  • 42
    Digitale Medien
    Digitale Medien
    Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 635-641 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Choroid plexus papilloma ; Choroid plexus carcinoma ; Prognosis ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sixty-seven tumor specimens of epithelial choroid plexus neoplasms obtained by 60 biopsies and 7 autopsies from 52 patients were investigated. Diagnoses of the first operations were choroid plexus papilloma (PP; 32 cases), choroid plexus papilloma with histological atypies (atypical PP; 6 cases), and choroid plexus carcinoma (PC; 14 cases). Carcinoembryonic antigen was expressed by 2 of the 3 biopsies autoptically recognized as metastatic carcinomas and by 2 autopsy cases of PC, while it was absent in all biopsies of true choroid plexus tumors. Tumor cells positive for transthyretin (TTR, prealbumin), S-100 protein (S100), and glial fibrillary acidic protein (GFAP) were detected in 39, 46 and 13, respectively, of the 49 cases of true choroid plexus tumors. Fourth ventricle tumors expressed more S100 (number of positive tumor cells) than lateral ventricle tumors, PP more S100 and TTR than atypical PP/PC. Tumors from patients 20 years of age and older expressed more GFAP and TTR than tumors from younger patients. Of the 30 patients with complete follow-up 19 were alive 2 to 11 years after surgery, including 7 recurrencies. Eleven died from the tumor 4 months to 7 years after surgery. The following histopathologic features (in order of decreasing significance) were correlated with poor prognosis (recurrency or fatal outcome): less than 50% of the tumor cells heavily positive for S100, presence of mitoses, absence of TTR-positive cells, brain invasion by cell nests, absence of marked stromal edema, and presence of necrotic areas. Our results indicate that some histologic features correlate significantly with poor prognosis and that immunohistochemical results correlate with tumor localization, age, and malignancy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00307632
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  • 43
    Digitale Medien
    Digitale Medien
    The involvement of the cerebral cortex in human immunodeficiency virus encephalopathy: a morphological and immunohistochemical study (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 51-59 
    Details
    ISSN: 1432-0533
    Schlagwort(e): AIDS ; HIV encephalopathy ; Immunohistochemistry ; Cortex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The encephalopathy resulting from direct infection of the brain by human immunodeficiency virus (HIV), which correlates clinically with the AIDS dementia complex, has been reported as being localized to the white matter where it induces myelin loss, gliosis and perivascular infiltration by mononuclear macrophages and multinucleated giant cells. Damage to the cortical grey matter in HIV encephalopathy was investigated in nine randomly selected HIV-positive cases with or without clinical or morphological evidence of encephalopathy and in five age-matched controls, using routine histology and immunohistochemical methods [glial fibrillary acidic protein (GFAP), microglia and HIV antibodies]. Increased numbers of GFAP-expressing astrocytes andRicinus communis agglutinin 1–120-expressing microglial cells were found in all the HIV-positive cases (including asymptomatic) and their severity could be correlated with the severity of the encephalopathy in the white matter: the increase in number of cells expressing GFAP was diffuse and the intensity of the staining higher than that of microglial cells. The subpial region was the most severely involved. It is suggested that involvement of the cortical grey matter is more common in HIV infection than previously suspected and that clinical evidence of a dementing process in AIDS is not necessarily due only to white matter lesions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00662637
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  • 44
    Digitale Medien
    Digitale Medien
    Leu-7 immunoreactivity in human and rat embryonic hearts, with special reference to the development of the conduction tissue (1990)
    Springer
    Anatomy and embryology 182 (1990), S. 553-562 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Immunohistochemistry ; Leu-7 ; Conduction system ; Embryo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution pattern of Leu-7 (HNK-1) in developing human embryonic hearts and rat hearts was studied by immunohistochemistry. Human and rat embryos at Streeter's stages XIII ∼ XX and fetus stage I were used. Leu-7, which is absent in the newborn rat heart, is expressed transiently in the embryo and fetus I stages. The earliest embryonic heart shows two incomplete circular structures with immunoreactivity in the myocardium along the primitive atrioventricular cushion and bulboventricular canal. These two structures become localized topographically in the definitive atrioventricular node and atrioventricular bundle after rearrangement and partial disappearance during embryonic development. At Streeter's stages XVIII ∼ XX, Leu-7 immunoreactivity appears to localize topographically in almost all the pathways of the conduction system, although some discontinuities are observed in the atrioventricular junction and atrial internodal tracts. Thereafter, immunoreactivity decreases gradually and differentially by site and stage. The precise nature of Leu-7 immunoreactive cells, that is, whether or not they are neurogenic or myogenic, is not revealed by this study. The present observations are discussed in connection with the hypothesis that specialized ring tissue is the primordium of the conduction system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186462
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  • 45
    Digitale Medien
    Digitale Medien
    Distribution of glycoconjugates in the optic vesicle and optic cup (1990)
    Springer
    Anatomy and embryology 182 (1990), S. 611-616 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Eye development ; Glycoconjugates ; Histochemistry ; Immunohistochemistry ; Lectins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Lectin histochemical methods and immunohistochemical techniques have been utilized to investigate and partially characterize glycoconjugates in the developing eye. Peanut-lectin-binding sites associated with radial glial cells were found in the diencephalon. In the optic primordia, binding sites associated with radial glia were masked by terminal sialic acid, and only reacted with peanut lectin when pretreated with sialidase. This finding indicates that glycoconjugates associated with diencephalic radial glia contain terminal galactose-β-(1→3)N-acetyl galactosamine, but glycoconjugates associated with radial glia in the optic primordia contain sialic acid→galactose-β(1→3)N-acetyl galactosamine. The selective distribution of galactose, N-acetyl galactosamine and fucose associated with radial glial cells has also been demonstrated. We postulate that these distributions mediate the shaping of the developing eye.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186468
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  • 46
    Digitale Medien
    Digitale Medien
    The gap junction family: structure, function and chemistry (1990)
    Springer
    Anatomy and embryology 182 (1990), S. 517-528 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Gap junction ; Structure ; Function ; Molecular biology ; Chemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Gap junctions are aggregates of transmembranous channels which bypass the extracellular space by transporting messenger molecules and ions from one cytoplasmic source to an adjacent cytoplasmic interior. The channels join the plasma membranes of adjacent cells by bridging the extracellular space between them. Thereby, cellular “compartments” which were once considered to be individual units are, in actuality, interconnected by a system of pathways which form a functional cellular syncytium. The evolutionary importance of a generalized intercellular communication system can be appreciated when one considers the widespread prevalence of gap junctions within animals of all multicellular phyla, and within almost all tissues of vertebrates. Only a few population of cells such as skeletal muscle cells (which are fused to form functional syncytia) and circulating blood cells are not equipped with gap junctions. This paper provides a brief review of the diverse structural, molecular and functional aspects of gap junctions as revealed by current research.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00186458
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  • 47
    Digitale Medien
    Digitale Medien
    Transferrin receptors in injured brain (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 686-688 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Transferrin receptor ; Brain injury ; Edema fluid ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells, probably macrophages. Although Tf-R were seen in proliferating cells, Tf-R were also observed in nonproliferating cells, many of them macrophages. The receptors perhaps bind transferrin in edema fluid and play an important role in lesion repair.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294248
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  • 48
    Digitale Medien
    Digitale Medien
    Immunoreactivity of canine and feline polyglucosan bodies for monoclonal antibody against human polyglucosan (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 217-218 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Immunohistochemistry ; Polyglucosan bodies ; Dog ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary With the use of monoclonal antibodies, raised against the human polyglucosan, positive staining of polyglucosan bodies (PGB) was detected in the brain, spinal cord and cecum of aged dogs. PGB in feline brain were also positively stained with these antibodies. These findings indicate that animal PGB share common antigenicity with human PGB.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00334511
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  • 49
    Digitale Medien
    Digitale Medien
    Polar spongioblastoma: an immunohistochemical and electron microscopical study (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 228-232 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Cerebral tumor ; Polar spongioblastoma ; Astrocytoma ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case is reported of a 9-year-old boy with a cerebral polar spongioblastoma. This neoplasm, first described by Russell and Cairns in 1947, is morphologically a distinct entity characterized by bipolar tumor cells with palisading nuclei. In the case under study immunoreactivity for neuron-specific enolase was found and ultrastructural features of developing neuronal elements were present. A neuro-endocrine nature was suggested by de Chadarévian et al. (1984) in a morphologically similar case. These findings are in contrast with the longheld view that the polar spongioblastoma is cytogenetically related to the embryonal radial glial cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00334514
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  • 50
    Digitale Medien
    Digitale Medien
    Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 418-423 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Fibroblast growth factor (FGF) ; Basic FGF ; Angiogenesis ; Brain tumors ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308718
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  • 51
    Digitale Medien
    Digitale Medien
    Rosenthal fibres: an immunohistochemical, ultrastructural and immunoelectron microscopic study (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 456-460 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Rosenthal fibers ; Immunohistochemistry ; Ultrastructure ; Neoplastic and reactive astrocytes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The nature of Rosenthal fibres (RF) was investigated in eight cases each of low-grade astrocytoma and reactive gliosis using immunohistochemical (IH) staining for glial fibrillary acidic protein (GFAP), electron microscopy (EM) and immunoelectron microscopy (IEM) by immunogold labelling technique. By IH under light microscopy (LM), three types of RF were seen, uniformly positive (type I), rim positive (type II) and completely negative (type III). EM showed variation in structural pattern of RF. Some RF contained large amount of glial filaments (GF) intermingled with RF while others with a large amount of electron dense material and less GF. Thus, the presence and amount of GF in RF appear to be responsible for the different types of IH staining under LM. IEM showed that all RF including the ones consisting of entirelh amorphous material possess immunoreactivity for GFAP. It is suggested that RF formation is a two-stage process, staring with excessive accumulation of GF within astrocytic processes followed by their gradual alteration into electron-dense amorphous material under the influence of some unknown metablic or other factors. The quantitative analysis of different types of RF suggests a difference in the rate of formation of RF in neoplastic and reactive conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308723
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  • 52
    Digitale Medien
    Digitale Medien
    Cross-reactivity of monoclonal antibody Leu-19 with some neuroectodermal and other non-immune tissues (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 520-527 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Natural killer cells ; Immunohistochemistry ; Leu-19 antigen ; Brain tumors ; Neuroendocrine cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Leu-19 antigen is a 200–220 kDa surface glycoprotein, initially detected on natural killer (NK) cells exhibiting non-major histocompatibility complex-restricted cytotoxity. Using a monoclonal antibody (mAb) directed against the Leu-19 molecule, we were unable to identify NK cells immunohistologically in cryostat sections of neuroectodermal tumors. Instead, mAb Leu-19 cross-reacted with the surfaces of the tumor cells, except for melanomas. It stained mesodermal tumor cells less intensely and did not stain those of carcinoma metastases. In three plasmocytomas, cells were observed, most likely NK cells, which extend Leu-19-positive cell processes towards to the unstained tumor cells. Furthermore, the Leu-19 antigen was identified on physiological tissues, especially on all neuroendocrine cells analyzed. The cross-reactions observed with Leu-19 mAb were confirmed using mAb NKH-1, which is also directed against the Leu-19 molecule. Thus, the expression of Leu-19 on neuroectodermal cells is another example of antigen sharing between specialized immune cells and the nervous system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00296112
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  • 53
    Digitale Medien
    Digitale Medien
    Histogenesis of intracranial haemangiopericytoma and haemangioblastoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 68-71 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Meningeal haemangiopericytoma ; Cerebellar haemangioblastoma ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An immunohistochemical study was performed on three meningeal haemangiopericytomas and four cerebellar haemangioblastomas (paraffin embedded) in an attempt to elucidate the uncertain histogenesis of these tumours. The tumour cells of all meningeal haemangiopericytomas show no expression of α-smooth muscle actin and, thus, no immunohistochemical proof of their true pericytic nature can be obtained. The stromal cells of cerebellar haemangioblastomas show foci of positive staining for S-100 protein, neuron-specific enolase and synaptophysin, thereby clearly indicating their neuroectodermal origin. These results allow the conclusion that the present nomenclature of these tumours is at least arguable and probably incorrect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294223
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  • 54
    Digitale Medien
    Digitale Medien
    Changes in glial cell markers in recent and old demyelinated lesions in central pontine myelinolysis (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 46-58 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Central pontine myelinolysis ; Demyelination ; Astrocytes ; Cell adhesion molecules ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An immunohistochemical study was performed to compare glial reactions in recent and old lesions of central pontine myelinolysis (CPM). Regions of demyelination and destruction of oligodendrocytes, showed reduced immunoreactivity of myelin basic protein (MBP), myelin-associated glycoprotein (MAG), transferrin, and carbonic anhydrase C (CA C). In addition, labeling of glial fibrillary acidic protein (GFAP) and S-100 protein revealed distinct dystrophic alterations of the astroglia. Remarkably, immunolabeling of GFAP was drastically reduced in astrocytic cytoplasm within freshly demyelinated lesions. Immunostaining of vimentin revealed a differential intracytoplasmic decoration of hypertrophic and dystrophic astrocytes in recent and old CPM lesions. Immunolabeling of desmin failed to stain glial cells. Monoclonal antibodies against HNK-1 exhibited greatly increased immunoreactivity both of persisting oligodendrocytes and of reactive fibrillary astrocytes in old CPM foci. In freshly demyelinated lesions, enhanced immunoreactivity of the X-hapten (3-fucosyl-N-acetyllactosamine) was prominent in astroglia and oligodendrocytes. Simultaneously, reactive astrocytes revealed intracytoplasmic labeling of laminin. Quantitation of GFAP+ astroglia in fresh CPM and control cases revealed an increase in the number of astrocytes within the demyelinated foci and in the surrounding nondemyelinated pontine tissue of CPM cases. The occurrence of astroglial alterations in the demyelinated foci of CPM could be interpreted as “astroglial dystrophy” which may represent a pathogenic factor in CPM. Furthermore, it is possible that changes of the glial microenvironment may influence the astroglia to revert transiently back to an immature phenotype as indicated by the enhanced expression of the X-hapten and HNK-1, and the de novo synthesis of vimentin and laminin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294221
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  • 55
    Digitale Medien
    Digitale Medien
    Synaptophysin expression in the striatum in Huntington's disease (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 88-91 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Huntington's disease ; Striatum ; Synaptophysin ; Calcineurin ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294227
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  • 56
    Digitale Medien
    Digitale Medien
    Cerebral medulloepithelioma — electron microscopy and immunohistochemistry (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 103-107 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Brain neoplasms ; Medulloepithelioma ; Primitive neuro-ectodermal tumor ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case is reported of a boy, 3 years of age, with a large medulloepithelioma in the left cerebral hemisphere. Medulloepitheliomas are rare tumors of the primitive medullar epithelium. Histological, immunohistochemical and electron microscopical findings are presented. We discuss previously reported cases, the ontogeny of this type of tumor and the relation to the socalled primitive neuro-ectodermal tumors (PNET).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294231
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  • 57
    Digitale Medien
    Digitale Medien
    Bromodeoxyuridine labeling study of intracranial meningiomas: proliferative potential and recurrence (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 311-317 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Meningioma ; Bromodeoxyuridine ; Cell kinetics ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ninety-six patients with intracranial meningiomas and two with hemangiopericytic variants received a 30-min intravenous infusion of bromodeoxyuridine (BrdUrd), 200 mg/m2, before tumor removal. Excised tumor specimens were stained by the indirect immunoperoxidase method to determine the BrdUrd labeling index (LI), or percentage of cells in DNA synthesis. The BrdUrd LI was 〈 1% in 63 (86.3%) of 73 nonmalignant meningiomas and 〈 1% in 20 (87%) of 23 malignant meningiomas. Of 23 malignant meningiomas 11 were recurrent tumors; 8 patients had recurrence 3 to 33 months after the study. The recurrence rate was 100% (five of five) in patients whose tumors had a BrdUrd LI 〉 5%, 44% (11 of 25) in those with a BrdUrd LI 1% to 5%, and 6.1% (4 of 66) in those with an LI 〈 1%. Thus, meningiomas with a BrdUrd LI 〉 1% may grow faster and recur more frequently. Among patients with malignant mengngiomas, the mean time to recurrence after the study was 7.5 months in those with a BrdUrd LI 〉 5% and 20.2 months for those with an LI 1% to 5%. The mean time to recurrence was 97.8 months in patients with nonmalignant meningiomas. Both hemangiopericytic variants were recurrent and showed LIs of 0.5% and 4.1%; the former tumor recurred 8 years after complete resection, while the latter recurred three times in 3.5 years. Thus, the proliferative potential of intracranial meningiomas as reflected by the BrdUrd LI appears to be a prognostic variable that can help to elucidate the biological behavior of individual meningiomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294650
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  • 58
    Digitale Medien
    Digitale Medien
    Coxsackie B antigen in the central nervous system of a patient with fatal acute encephalitis: immunohistochemical studies of formalin-fixed paraffin-embedded tissue (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 216-221 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Central nervous system ; Coxsackie B virus ; Encephalitis, viral ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case of fatal acute encephalitis due to Coxsackie B1 virus is described. Confirmation of Coxsackie B virus as the etiological agent of encephalitis was based on identification of the virus antigen in formalin-fixed paraffin-embedded tissue sections. In the past, the diagnosis was obtained by serological studies of peripheral blood and viral isolation. This is the first report in which indirect immunofluorescent and immunoper-oxidase methods using rabbit antiserum raised against Coxsackie B types 1–6 was utilized in determining the etiology of encephalitis. It must be emphasized that these methods can be used both on biopsy or autopsy specimens, even retrospectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308928
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  • 59
    Digitale Medien
    Digitale Medien
    Ubiquitin-immunoreactive filamentous inclusions in anterior horn cells of Guamanian and non-Guamanian amyotrophic lateral sclerosis (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 233-238 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyotrophic lateral sclerosis ; Guam ; Ubiquitin ; Immunohistochemistry ; Anterior horn cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Immunohistochemical studies with an antibody to ubiquitin revealed the presence of filamentous inclusions in spinal anterior horn cells in all of six patients with Guamanian amyotrophic lateral sclerosis (ALS) and one of six cases of parkinsonism-dementia complex (PD) on Guam. Similar ubiquitin-reactive filamentous inclusions were found in all of seven non-Guamanian sporadic ALS patients examined. No similar inclusions were seen in six normal controls or in non-ALS patients who had chromatolytic neurons. The filamentous inclusions differed from spinal neurofibrillary tangles, a characteristic feature of Guamanian ALS and PD, since they were restricted to anterior horn cells and did not react with anti-tau antibody. The chromatolytic neurons of non-ALS patients occasionally had weak diffuse immunoreactivity, but no focal inclusions were detected. These results suggest that ubiquitin-reactive focal filamentous inclusions may reflect a characteristic degenerative process of anterior horn cells of motor neuron disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294639
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  • 60
    Digitale Medien
    Digitale Medien
    Distribution of neuropeptide Y-like immunoreactivity in the normoganglionic and aganglionic segments of human colon (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 469-474 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Neuropeptide Y ; Immunohistochemistry ; Hirschsprung's disease ; Aganglionosis ; Man
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The localisation and distribution of neuropeptide Y (NPY)-like immunoreactivity were studied by use of immunohistochemical methods in gut tissues from 19 patients with Hirschsprung's disease, including 4 cases of long segment aganglionosis. In the normoganglionic segment, immunoreactive cell bodies and nonvaricose processes were seen within both myenteric and submucous plexuses. A scarce supply of varicose fibres was found in the lamina propria mucosae, muscularis mucosae and longitudinal muscle layer. NPY fibres were more frequently encountered in the circular muscle layer, although with a weakly immunostaining intensity. In addition, blood vessels in the submucosal connective tissue were surrounded by a typical plexus of varicose, NPY-positive fibres. Immunoreactive endocrine cells could be detected in the colonic epithelium. In the aganglionic segment, numerous nerve fasciculi comprising a small to moderate number of NPY fibres with varicosities were observed throughout the entire layer of the colonic wall. A few varicose, NPY-positive fibres were also contained in the relatively large, hypertrophic nerve fasciculi located in the intermuscular zone and submucosal connective tissue. NPY-immunoreactive fasciculi were more densely distributed in the distal aganglionic segment than in the proximal aganglionic one. On the other hand, the distribution of NPY-positive fibres in long segment aganglionosis was quite different from that in short segment type; in cases of long segment type, no immunoreactive nerve fibres were detected within the circular muscle layer of the proximal aganglionic segment near the oligoganglionic segment and only a few fibres were observed within the hypertrophic nerve bundle of the intermuscular zone. The present results suggest that NPY-like immunoreactive nerves in the human colon have a dual origin of intrinsic and extrinsic elements. The origin and nature of extrinsic NPY nerve fibres in the human colon are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294605
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  • 61
    Digitale Medien
    Digitale Medien
    Immunohistochemical localization of synaptophysin (p38) in the pineal gland of the Mongolian gerbil (Meriones unguiculatus) (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 433-440 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Synaptophysin ; Immunohistochemistry ; Pineal gland ; Pinealocytes ; Meriones unguiculatus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Synaptophysin (protein p38), a major integral membrane glycoprotein of small presynaptic vesicles, was localized immunohistochemically in semithin sections of the superficial pineal gland of the Mongolian gerbil (Meriones unguiculatus). Synaptophysin immunoreactivity could be detected in all pinealocytes, which were visualized with antibodies directed against neuron-specific enolase (NSE) in adjacent sections. No p38 immunoreactivity was discernible in the interstitial glial cells, which showed a heterogeneous pattern of immunostaining for the intermediate filament proteins glial fibrillary acidic protein (GFAP) and vimentin. Pinealocytes exhibited considerable intercellular differences in the densities of immunostaining. The various degrees of synaptophysin immunoreactivities in pinealocytes were not correlated with the densities of NSE immunostaining. Nerve terminals and varicosities displayed stronger immunoreactivities than pinealocytes. They were particularly numerous in the perivascular spaces. It is not clear whether this distribution indicates an innervation of pineal capillaries in addition to the functionally important innervation of pinealocytes. Several highly p38-positive dots of variable size were a conspicuous feature throughout the gland. By the consecutive semithin-thin section technique, they could be identified as processes of pinealocytes, filled with accumulations of small clear vesicles. Obviously, these vesicles represent the major site of synaptophysin immunoreactivity in pinealocytes. In the gerbil, similar vesicles have been ascribed a role in the secretory activity of the gland, and/or in the transport of calcium. The intercellular differences in the degrees of p38 immunostaining may, therefore, reflect different states of a specific cellular activity. The presence of synaptophysin in pinealocytes of the normal pineal, including the deep portions of the gland, emphasizes the paraneuronal character of these cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02433790
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  • 62
    Digitale Medien
    Digitale Medien
    Development of the dorsal pancreatic primordium transplanted into the third ventricle of rats (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 441-452 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Development ; Pancreatic primordium ; Transplantation ; Immunohistochemistry ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The dorsal pancreatic primordia of 12.5-day-old rat embryos transplanted into the third ventricle of adult female rats were immunohistochemically examined 10, 20 and 40 days after transplantation. On day 10, the grafts grew into an epithelial sacculus (S) with a thick subepithelial tissue (ST). Tubular and vesicular structures with a single cuboidal epithelium were found within the wall of the S, but they underwent thereafter a regression without allowing the primordia to differentiate into the exocrine acinar tissues. In contrast with this, pancreatic hormone-containing cells existed in the ST, and were arranged like the islands of a mature animal. The tissue also has smooth muscle fibers and neurons. When the primordium was grafted along with its root connected to the duodenum, gut-like tubular structures differentiated, showing mucosa with villi and crypts, submucous mesenchymal tissue and muscle layers. The mucosa possesses epithelial cells immunoreactive for the pancreatic hormones, and the muscle layers have the myenteric plexuses. These findings seem to provide further evidence that in the rat pancreas, pancreatic-hormone-containing cells differ from the acinar cells in origin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02433791
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  • 63
    Digitale Medien
    Digitale Medien
    Immunohistochemical detection of heterophile Hanganutziu-Deicher antigen in human malignant melanoma (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 179-182 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Human malignant melanoma ; Hanganutziu-Deicher antigen ; N-Glycolylneuraminic acid ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The Hanganutziu-Deicher (HD) antigen is a heterophile antigen whose immunodominant molecule is N-glycolylneuraminic acid, a sialic acid that cannot be found in normal tissues of either humans or chickens. Using biotinylated chicken anti-HD antibody purified with affinity chromatography, expression of HD antigen was immunohistochemically investigated in formalin-fixed tissues of human malignant melanoma. HD antigen-positive melanoma cells were clearly demonstrated in 7 of 11 lesions of malignant melanoma. No HD antigen-positive cells were found in 8 lesions of melanocytic nevus, and no components of normal human skin including epidermal melanocytes were stained with the antibody. This study is the first that immunohistochemically demonstrates HD antigen in tissue sections of human malignant melanoma. The expression of the HD antigen in transformed human melanocytes may have great immunological significance because the antigen is absent from normal human tissues and is immunogenic in humans.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00372619
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  • 64
    Digitale Medien
    Digitale Medien
    Altered keratin expression in ichthyosis hystrix Curth-Macklin (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 227-233 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Genodermatoses ; Keratinization disorders ; Fetal cytokeratins ; Immunohistochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pathogenesis of a rare form of the ichthyotic diseases, ichthyosis hystrix Curth-Macklin, was investigated by immunohistochemistry and electron microscopy. Monoclonal antibodies (Mabs) against keratins expressed in normal basal cells (PKK2 and KA1), Mabs against keratins only present in normal fetal skin (PKK1), and Mabs against keratins 1, 2, 10, and 11 (KA5 and K8.60) were used. The Mabs reacting with normal basal cells showed an increased reaction with many cell layers. The Mab PKK1 distinctly reacted with the basal cell layer, suggesting an expression of fetal keratins. Electron microscopic study of both normal-looking and involved skin revealed the keratinization disorder characterized by tonofilament shells, perinuclear vacuoles, and binuclear keratinocytes. The results suggest that there is no prematurity of keratinization, but rather a pathological expression of specific keratin genes leading to expression of fetal keratins in this form of ichthyosis hystrix.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00371641
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  • 65
    Digitale Medien
    Digitale Medien
    Evaluation of encephalic ventricular volume from the magnetic resonance imaging scans of thirty-eight human subjects (1990)
    Springer
    Surgical and radiologic anatomy 12 (1990), S. 287-290 
    Details
    ISSN: 1279-8517
    Schlagwort(e): Cerebral ventricular volume ; Cerebrospinal fluid volume ; Volume of encephalic ventricles ; Computerized tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé La détermination exacte du volume des ventricules cérébraux est importante en clinique comme par exemple dans la démence présénile d'Alzheimer, la schizophrénie et l'hypertension intracrânienne bénigne. Des études antérieures ont étudié la fiabilité de la résonance magnétique nucléaire en pratique clinique pour évaluer le volume des ventricules cérébraux. Toutefois une évaluation correcte dans les conditions pathologiques implique une bonne connaissance des données morphométriques du sujet normal. Pour établir ces données sur « le sujet normal », nous avons étudié les coupes obtenues en IRM chez 38 sujets apparemment indemnes de toute pathologie; nous avons calculé le volume ventriculaire dans chaque cas en utilisant des méthodes mises au point auparavant dans notre laboratoire. Les résultats ont été ensuite comparés avec ceux obtenus par d'autres études utilisant soit des moules ventriculaires, soit des coupes tomographiques computérisées. Le volume ventriculaire total moyen chez 38 sujets est de 17,4 cm3, mais il est chez les sujets masculins de 16,3 cm3 et chez les sujets de sexe féminin de 18 cm3. Une corrélation faible mais significative a été trouvée entre l'âge du sujet et le volume ventriculaire, étant entendu que la taille du ventricule augmente avec l'âge.
    Notizen: Summary Accurate volume determination of the encephalic ventricles is of importance in several clinical conditions, including Alzheimer's presenile dementia, schizophrenia, and benign intracranial hypertension. Previous studies have investigated the accuracy with which magnetic resonance imaging (MRI) can be used in clinical practice to evaluate the encephalic ventricles. However, adequate evaluation of pathological conditions depends on a sufficient amount of morphometric data from normal subjects. To begin establishing this data base for “normal” subjects, we evaluated the MRI scans of 38 subjects found to have no apparent pathology and calculated the ventricular volume in each case by using methods previously developed in our laboratory. The results were then compared with published volumes determined from studies that used either ventricular casts or computerized tomographic scans. The average total ventricular volume for all 38 subjects was 17.4 cm3, while that for males was 16.3 cm3 and that for females was 18.0 cm3. A small but significant correlation was found between age of subject and ventricular volume, with ventricular size increasing with age.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01623707
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  • 66
    Digitale Medien
    Digitale Medien
    A correlative study of MR images and cryo-sections of the neonatal hip (1990)
    Springer
    Surgical and radiologic anatomy 12 (1990), S. 43-51 
    Details
    ISSN: 1279-8517
    Schlagwort(e): Cryosections ; Magnetic resonance imaging ; Neonatal hip anatomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé L'anatomie complexe de la hanche du nouveau-né est souvent difficile à illustrer. Récemment, l'IRM a été utilisée pour étudier la hanche normale et pathologique du nouveau-né. Nous avons corrélé des explorations IRM de la hanche d'un enfant mort-né avec des cryosections faites dans divers plans. La technique de coloration de Mallory-Cason a été utilisée pour montrer le détail des structures anatomiques de la hanche normale. Dans ce travail l'IRM s'est avérée un excellent moyen d'exploration de l'anatomie de la hanche.
    Notizen: Summary The complex anatomy of the neonatal hip is often difficult to image. Recently, magnetic resonance imaging (MRI) has been used to evaluate the normal and abnormal neonatal hip. We correlated the MRI scans of the hip of a newborn cadaver with multiplanar cryo-sections stained according to Mallory-Cason, to detail the anatomic structures of the normal hip joint space. In our experience, MRI was shown to provide excellent depiction of hip anatomy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02094125
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  • 67
    Digitale Medien
    Digitale Medien
    Double thoracic drainage of a left inferior vena cava (1990)
    Springer
    Surgical and radiologic anatomy 12 (1990), S. 225-227 
    Details
    ISSN: 1279-8517
    Schlagwort(e): Venae cavae, abnormalities ; Azygos vein ; Computed tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Les auteurs rapportent un cas de veine cave inférieure gauche avec un drainage hémiazygos puis azygos préférentiel associé à un drainage accessoire par la veine intercostale supérieure gauche. Cette malformation congénitale exceptionnelle entrant dans le cadre d'un syndrome polysplénique a été étudiée par cavographie, tomodensitométrie et imagerie par résonance magnétique.
    Notizen: Summary The authors report a case of left IVC with a preferential hemiazygos-azygos drainage associated with an accessory left superior intercostal vein drainage. This exceptional congenital malformation which finds its place in polysplenia was studied by cavography, CT and MR imaging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01624528
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  • 68
    Digitale Medien
    Digitale Medien
    Comparative study between ultrasound, computed tomography, intra-arterial digital subtraction angiography, and magnetic resonance imaging in the differentiation of tumors of the liver (1990)
    Springer
    Abdominal imaging 15 (1990), S. 102-106 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Liver tumors ; Ultrasound ; Magnetic resonance imaging ; Angiography ; Computed tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Forty-one patients with liver tumor have been evaluated with ultrasound (US), computed tomography (CT), intra-arterial digital subtraction angiography (IA-DSA), and magnetic resonance imaging (MRI) in order to establish the accuracy of each technique. In group A (24 patients), in which all four imaging modalities were performed, our results show that MRI detected all hemangiomas (25/25) compared to 22/25, 21/25, and 20/25 with US, CT, and IA-DSA, respectively. No difference between the various methods was seen in the case of hepatoma. Finally, in the patients with metastases, all four techniques had the same sensitivity (100%) but the specificity of MRI was also 100%, compared to 33% for IA-DSA and 66% for US and CT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01888749
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  • 69
    Digitale Medien
    Digitale Medien
    Imaging of congenital esophageal cysts in adults (1990)
    Springer
    Abdominal imaging 15 (1990), S. 279-281 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Congenital esophageal cysts, adults ; Computed tomography ; Ultrasound, endoscopic ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The radiologic imaging of esophageal cysts (EC) in adults is described. These rare cysts, often detected incidentally on routine chest radiographs, seldom produce symptoms, but they may cause precordial sensations, arrhythmias, and dysphagia. They may also bleed and become malignant. As surgical excision is the treatment of choice, the preoperative diagnosis must be exact. For this, magnetic resonance imaging (MRI) or endoscopic ultrasound seem to be the imaging methods of choice even if a plausible diagnosis can be advanced on computed tomography (CT). Chest x-ray or esophagus roentgenogram have little differential diagnostic value.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01888796
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  • 70
    Digitale Medien
    Digitale Medien
    Mosaic pattern of encapsulated hepatocellular carcinoma: Correlation of magnetic resonance imaging and pathology (1990)
    Springer
    Abdominal imaging 15 (1990), S. 238-240 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Liver, neoplasms ; Hepatocellular carcinoma ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Internal architecture of an encapsulated hepatocellular carcinoma (HCC) was studied with magnetic resonance imaging and histologic correlation. The capsule of HCC showed low intensity relative to liver on both T1- and T2-weighted images. The T1-weighted images were superior to the T2-weighted images in delineating the capsule of HCC. The tumor showed a mosaic pattern, which was a configuration composed of multiple compartments of different intensities, reflecting viable tumor nodules and a necrotic portion. Viable tumor nodules, composed of trabeculae of polygonal cells resembling the normal liver cell with well-formed sinusoids, showed low intensity relative to liver on T1-weighted images and high intensity on T2-weighted images. The necrotic portion, composed of coagulation of amorphous, thick eosinophilic material without hemorrhage or inflammatory reaction, showed low intensity relative to liver on both T1- and T2-weighted images. The T2-weighted images were superior to the T1-weighted images in demonstrating the mosaic pattern of HCC.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01888784
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  • 71
    Digitale Medien
    Digitale Medien
    The laminar distribution and postnatal development of serotonin-immunoreactive axons in the cat primary visual cortex (1990)
    Springer
    Experimental brain research 81 (1990), S. 257-266 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Serotonin ; Area 17 ; Postnatal development ; Immunohistochemistry ; Cat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The laminar distribution and postnatal development of profiles immunoreactive to antibodies directed against serotonin (5-hydroxytryptamine, 5-HT) have been investigated in the primary visual cortex (striate cortex, area 17) of cats. In the adult cat, profiles with serotonin-like immunoreactivity consist exclusively of fibers which exhibit laminar differences in density and predominant orientation. Immunoreactive fibers are dense in layers I–III, less dense in layer V, and sparse in layers IV and VI. In layers I and VI the trajectories of these fibers are mainly tangential to the pial surface; in layers II–V they are predominantly radial and more irregular. The vast majority of immunoreactive fibers consists of fine axons with frequent small varicosities. In addition, there are a few thick axons. In 2-week-old cats, immunoreactive fibers are sparsely distributed through layers II–V. By 4 weeks, fiber density has decreased still further in layer IV and increased in layers I–III. By 6 weeks, the laminar pattern resembles that of adult cats except that fiber density is still lower than in adults. At three months of age, the mature pattern is established.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228114
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  • 72
    Digitale Medien
    Digitale Medien
    Expression of neuropeptide Y immunoreactivity in the rat nucleus accumbens is under the influence of the dopaminergic mesencephalic pathway (1990)
    Springer
    Experimental brain research 81 (1990), S. 363-371 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Neuropeptide Y ; Dopaminergic mesencephalic pathway ; Nucleus accumbens ; Immunohistochemistry ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The density of neuropeptide Y (NPY) immunostained neurons examined in the rat nucleus accumbens (NAcc) was shown to be constant across the anteroposterior extent of the nucleus and did not present any right-left hemispheric difference. Selective unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigral dopaminergic neurons induced, 15 to 21 days later, a bilateral decrease in the NPY neuron density which was, interestingly, more marked in the contralateral than in the ipsilateral NAcc. Dopamine depletion induced by α-methylparatyrosine treatment elicited a decrease in NPY neuronal density similar in amplitude to that induced by the 6-OHDA lesion in the ipsilateral NAcc suggesting that similar mechanisms underly both NPY responses. In both experimental conditions, changes in NPY immunostaining were quite homogeneous in the two antero-posterior NAcc portions arbitrarily considered. Apomorphine treatment in animals with 6-OHDA injury completely reversed the ipsilateral lesion effect in the anterior part of the NAcc but only partially the contralateral one. In contrast, no significant effect of apomorphine was observed in either side of the NAcc posterior portion. This data suggests the involvement of at least 2 components in the NPY neuron responses to the lesion. The component reversed by apomorphine treatment was presumed to be directly linked to the DA depletion, while the second component not antagonized by apomorphine was considered independant on DA transmission. These data therefore provide morphological evidence for the occurence of complex functional interactions between dopaminergic afferents and NPY-containing neurons within the NAcc.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228127
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  • 73
    Digitale Medien
    Digitale Medien
    Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity in axotomized motoneurons (1990)
    Springer
    Experimental brain research 79 (1990), S. 212-216 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Neuropeptide ; Plasticity ; Nerve injury ; Spinal cord ; Immunohistochemistry ; Cat ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary By use of fluorescence immunohistochemistry it is shown that sciatic nerve section in cat and rat induces increased levels of immunoreactive calcitonin gene-related peptide (CGRP) in axotomized motoneurons. In the rat, this effect was clearly seen at 2–5 days postoperatively, but could not be demonstrated after 11–21 days. These findings are discussed in relation to previously proposed roles for CGRP in motoneurons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228891
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  • 74
    Digitale Medien
    Digitale Medien
    Synapsin I expression in the rat retina during postnatal development (1990)
    Springer
    Experimental brain research 82 (1990), S. 25-32 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Retina ; Development ; In situ hybridization ; Gene expression ; Immunohistochemistry ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The expression of the synapsin I gene was studied during postnatal development of the rat retina at the mRNA and protein levels. In situ hybridization histochemistry showed that synapsin I mRNA was expressed already in nerve cells in the ganglion cell layer of the neonatal retina, while it appeared in neurons of the inner nuclear layer from postnatal day 4 onward. Maximal expression of synapsin I mRNA was observed at P12 in ganglion cells and in neurons of the inner nuclear layer followed by moderate expression in the adult. At the protein level a shift of synapsin I appearance was observed from cytoplasmic to terminal localization during retinal development by immunohistochemistry. In early stages (P4 and P8), synapsin I was seen in neurons of the ganglion cell layer and in neurons of the developing inner nuclear layer as well as in the developing inner plexiform layer. In the developing outer plexiform layer synapsin I was localized only in horizontal cells and in their processes. Its early appearance at P4 indicated the early maturation of this cell type. A shift and strong increase of labelling to the plexiform layers at P12 indicated the localization of synapsin I in synaptic terminals. The inner plexiform layer exhibited a characteristic stratified pattern. Photoreceptor cells never exhibited synapsin I mRNA or synapsin I protein throughout development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00230834
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  • 75
    Digitale Medien
    Digitale Medien
    Immunohistochemical studies on the cellular localization of GABAA-receptors in explant cultures of rat central nervous system using a monoclonal antibody (1990)
    Springer
    Experimental brain research 82 (1990), S. 667-671 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Immunohistochemistry ; Monoclonal antibody ; GABAA-receptors ; Tissue cultures ; Spinal cord ; Brain stem ; Cerebellum ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Explant cultures of rat spinal cord, brain stem and cerebellum were used to visualize GABAA-receptors by means of immunohistochemistry. For these studies we have incubated the cultures with the monoclonal antibody bd 17 against the β-subunit of the GABAA/benzodiazepine/chloride channel complex. In spinal cord cultures, many interneurones were immunoreactive whereas only a small number of large neurones, probably motoneurones was specifically stained. In brain stem cultures, groups of large and medium-sized neurones showed immunoreactivity. In cultures of cerebellum, a great number of neurones was specifically stained. Granule cells showed the strongest immunoreactivity whereas other neurones, presumably Purkinje cells and interneurones, were only moderately stained. The immunoreactivity was mainly confined to the cell bodies of the neurones while their processes were only weakly or not stained. In contrast to neurones, no immunoreactivity could be detected on astrocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228810
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  • 76
    Digitale Medien
    Digitale Medien
    Termination patterns of calcitonin gene-related peptide-immunoreactive nerve fibers in the dorsal horn of the human spinal cord (1990)
    Springer
    Experimental brain research 80 (1990), S. 609-617 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Calcitonin gene-related peptide ; Human spinal cord ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary CGRP-immunoreactive varicose nerve fibers displayed three kinds of termination patterns in the cervical, thoracic and lumbar segments of the human spinal cord. Bundles of immunoreactive fibers formed a loose network in lamina I. A homogenous band of immunoreactive fibers filled lamina II. Multiple bundles of CGRP-positive fibers coursed through the superficial laminae towards deep portions of the grey matter. In the lumbar segments, in contrast to the cervical and thoracic segments, the bundles could be followed deep into the dorsal funiculus. Bundles of varicose immunoreactive fibers were seen to twine around the dendrites of neurons located in lamina I, in the dorsal funiculus of the lumbar segments and deep in the dorsal horn (laminae III–V). The corresponding types of large and medium-sized neurons were found in silver impregnated adjacent spinal cord sections. It is suggested that neurons in the above locations preferentially receive multiple contacts from CGRP-containing nerve fibers along their extensive dendritic arborizations (CGRP-target neurons).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228000
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  • 77
    Digitale Medien
    Digitale Medien
    Gadolinium-DTPA enhanced MR imaging in tuberous sclerosis (1990)
    Springer
    Neuroradiology 31 (1990), S. 492-497 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Tuberous sclerosis ; Magnetic resonance imaging ; Computed tomography ; Gadolinium-DTPA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ten patients with clinical tuberous sclerosis were examined with CT and MR imaging, before and after IV contrast in order to determine the role of Gd-DTPA. Gd-DTPA enhancement occured in eleven subependymal nodules which did not enhance on CT after IV contrast. As illustrated by previous CT and pathologic observations and related to the histologic similarity of the subependymal nodules and giant-cell astrocytomas, these hyperintense nodules could represent active lesions with the potential to evolve. Four giant-cell astrocytomas were detected both with CT and Gd-DTPA-enhanced MRI; tumor conspicuity and size assessment were improved by postcontrast MRI in two cases. No cortical tuber or heterotopic cluster enhanced; T2-weighted sequences therefore remain necessary for their detection. If pre and post-Gd-DTPA T1-and T2-weighted imaging is negative, CT is clearly the most sensitive modality in the detection of the small calcified subependymal nodules.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00340129
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  • 78
    Digitale Medien
    Digitale Medien
    MR imaging of wallerian degeneration in the human brain stem after ictus (1990)
    Springer
    Neuroradiology 32 (1990), S. 191-195 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Cerebral infarction ; Cerebral hemorrhage ; Brain stem ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Magnetic resonance (MR) imaging of wallerian degeneration in the brain stem was studied in 30 hemiplegic patients within 12 months of ictus. As early as 25 days after the ictus, decreased signal intensities on proton-density (PD)-weighted images were observed in the brain stem ipsilaterally. This hypointensity gradually approached an isointense stage during 70–80 days after the ictus, abnormal intensities were not detected in any pulse sequence. We termed this phenomenon “Fogging effect of wallerian degeneration”. In later stages, at least 81 days after the ictus, increased signal intensities on T2-weighted images, with or without decreased signal intensities on T1-weighted images, were observed in the brain stem, ipsilaterally. Finally, at least six months after the ictus, mild shrinkage of the ipsilateral brain stem was newly detected on the T1-weighted images. MR imaging has proven to be a sensitive diagnostic modality for evaluating wallerian degeneration in the brain stem.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00589109
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  • 79
    Digitale Medien
    Digitale Medien
    A follow-up study by CT and MRI in 3 cases of Japanese encephalitis (1990)
    Springer
    Neuroradiology 32 (1990), S. 215-219 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Japanese encephalitis ; Sequelae ; X-ray computed tomography ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A follow-up study by CT and MRI in 3 cases of Japanese encephalitis (JE) was performed. Neurologically dementia, forced laughing, tetraplegia and parkinsonism were observed as sequelae. In the CT and MR scans about 3 years after the onset of JE, low-density areas (LDAs) or abnormal signal intensities had remained in the thalamus and basal ganglia. The abnormalities were also found in the brain stem. When the main lesions shown by CT and MRI were compared with those of the acute stage, T2-weighted MRI clearly revealed multiple small areas with high signal intensities, although those in the acute stage had shown diffuse abnormal signals. These findings may be useful in helping to identify JE a long time after the onset.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00589115
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  • 80
    Digitale Medien
    Digitale Medien
    Focal pachygyria with unusual vascular anomaly (1990)
    Springer
    Neuroradiology 32 (1990), S. 237-240 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Pachygyria ; Vascular anomaly ; Perfusion failure ; Magnetic resonance imaging ; Neuropathology
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A case of focal pachygyria with an unusual vascular anomaly is reported. Preoperative magnetic resonance imaging demonstrated few and broad gyri, and an abnormally thickened cortex of the right frontal lobe. In addition, T2-weighted imaging showed a high intensity lesion beneath the thickened cortex. In the pachygyric cortex, the peripheral portions of the arteries were tortuous and irregularly dilated, and prominent deep medullary veins were found draining into the subependymal veins. Histological examination revealed a decreased number of neurons with no tendency towards lamination, and degenerative changes with gliosis in the white matter. These findings suggest that the etiology of this anomaly may be gradual perfusion failure restricted to the territory of the anomalous vessels through the period of neuronal migration to the post-migratory, perinatal stage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00589120
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  • 81
    Digitale Medien
    Digitale Medien
    MRI of radiation induced spinal cord glioma (1990)
    Springer
    Neuroradiology 32 (1990), S. 331-333 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Radiation induced glioma ; Magnetic resonance imaging ; Spinal cord ; Hodgkin's disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Radiation induced neoplasms of the spinal cord are rare lesions. This report details the MR evaluation of a patient with radiation induced astrocytoma of the cervical cord. The diagnosis of second primary neoplasm should be considered in patients with prior radiation therapy when MRI demonstrates an intramedullary lesion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593057
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  • 82
    Digitale Medien
    Digitale Medien
    The clinical applications of echo planar imaging in Neuroradiology (1990)
    Springer
    Neuroradiology 32 (1990), S. 367-370 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Echo planar ; Brain ; Spine ; High spped ; Fast imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ultra high speed echo-planar imaging gives an imaging time typically of the order of a few minutes, facilitating throughput, improving patient tolerance and allowing real time dynamic studies. A complete two dimensional image may be aquired in a single shot lasting between 64 and 128 ms. In echo planar imaging the whole of k-space is sampled as a continuous trajectory. By a rapidly switched Gy frequency encoding gradient, a train of gradient echoes is formed, each corresponding to a line in the k plane. Variable degrees at T2- or T1-weighting can be produced by methods outlined. High quality 128×128 transverse axial inversion recovery images of 5–10 mm thickness are obtained in 128 ms plus the inversion time.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00588470
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  • 83
    Digitale Medien
    Digitale Medien
    Cine MR in the evaluation of normal and abnormal CSF flow: intracranial and intraspinal studies (1990)
    Springer
    Neuroradiology 32 (1990), S. 371-391 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Cerebrospinal fluid flow ; Hydrocephalus ; Spinal cord cyst ; Cine-MR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Evaluation of intracranial and intraspinal CSF flow was accomplished by the use of cardiac gated gradient echo magnetic resonance (MR) technique. Normal patterns of pulsatile flow within the ventricles, cisterns and cervical subarachnoid space were established by this technique and these observations were compared to prior description of CSF flow. With systole there is downward (caudal) flow of CSF in the aqueduct of Sylvius, the foramen of Magendie, the basal cisterns and the dorsal and ventral subarachnoid spaces while during diastole, upward (cranial) flow of CSF in these same structures is seen. The relationships between the cardiac cycle and the CSF pulsations are demonstrated on both magnitude reconstruction and phase reconstruction MR images. Calculations of actual fluid velocity within CSF containing spaces can be obtained from the phase reconstruction images and holds promise for a more accurate analysis of CSF flow. In conditions which result in alterations of flow, cine MR dramatically shows either obstruction or excessively turbulent flow within the CSF pathways. The site of obstructed flow whether in the third ventricle, aqueduct, fourth ventricle, or subarachnoid space can be appreciated by changes in or absence of the normal hypointense signal. Cystic cord lesions such as congenital syringohydromyelia and posttraumatic spinal cord cysts may show pulsatile flow of CSF, a fact which can relate to progressive enlargement of these cysts. The distinction between myelomalacia and cyst formation in the cord is facilitated by the technique. Although the use of cine MR for the analysis of CSF flow is in its infancy, our experience indicates that this technique is useful in a wide range of pathological conditions including, but not limited to, conditions resulting in hydrocephalus or cystic cord lesions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00588471
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  • 84
    Digitale Medien
    Digitale Medien
    Visualization of isolated trigeminal nerve invasion by lymphoma using Gadolinium-enhanced magnetic resonance imaging (1990)
    Springer
    Neuroradiology 32 (1990), S. 531-532 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Trigeminal neuropathy ; Lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 50-year-old man with active histiocytic lymphoma for 12 years developed an isolated right trigeminal neuropathy. Initial evaluation with head computed tomography, X-rays of the skull base, bone scan, and cerebrospinal fluid analysis including cytology were normal. Gadolinium-enhanced magnetic resonance imaging (MRI) showed enlargement of the proximal third of the right trigeminal nerve. Gadolinium-enhanced MRI can be useful for the early demonstration of cranial nerve invasion by lymphoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02426474
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  • 85
    Digitale Medien
    Digitale Medien
    Neuroradiological examination of thoracic radiculo-myelopathy due to ossification of the ligamentum flavum (1990)
    Springer
    Neuroradiology 32 (1990), S. 38-42 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Spinal cord compression ; Computed tomography ; Magnetic resonance imaging ; Ossification of ligamentum flavum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sixteen cases of thoracic radiculomyelopathy due to ossification of the ligamentum flavum (OLF) were analyzed. The patients ranged in age from 39 to 78 years (average 57 years). There were 13 men and 3 women. A significant predilection of OLF for the lower thoracic spine (T9/10, T10/11, T11/12) was noticed. Plain X-ray of the thoracic spine and multidirectional tomography could give important information about the site of ossification. Computed tomography with the intrathecal injection of the water-soluble contrast material clearly demonstrated the ossification and the degree of compression of the spinal cord. The disadvantages of using computed tomography for diagnosing OLF included the necessity for the scan level to be previously decided by other methods because computed tomography of the entire spine was impractical. Magnetic resonance imaging was performed in 14 patients and gave important information about OLF and the compression of the spinal cord. The combination of MRI and computed tomography seems the most useful for the precise diagnosis of OLF.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593939
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  • 86
    Digitale Medien
    Digitale Medien
    Sodium-23 magnetic resonance brain imaging (1990)
    Springer
    Neuroradiology 32 (1990), S. 416-420 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Brain ; Sodium ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This is a review of recent work in23Na MR imaging. The main emphasis of recent papers has been pulse sequences that, with appropriate postprocessing, give images of the fast, slow, and intermediate components of T2 decay. The assignment of compartmental designation to the T2 component remains a problem except for homogeneous structures easily identifiable anatomically (ventricles, superior sagittal sinus, globe of the eye). Compartmental distribution of sodium is described. The predominance of the interstitial and plasma compartment, the invisibility of part of the intracellular sodium, and the difficulty in imaging the very fast T2 component of visible intracellular sodium make the usual Na spin-echo image essentially an image of the interstitial and plasma space. Use of super paramagnetic iron oxide coupled to dextran as a contrast medium may help to identify the plasma compartment. Because the usual Na MR images are essentially interstitial and plasma images, our own interest is in observing functional changes in these compartments. Another proposed application is the detection of the very fast T2 component in brain tumors to aid in defining tumor grade and extent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00588475
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  • 87
    Digitale Medien
    Digitale Medien
    Multiple slice FLASH imaging: An improved pulse sequence for contrast enhanced MR brain studies (1990)
    Springer
    Neuroradiology 32 (1990), S. 474-480 
    Details
    ISSN: 1432-1920
    Schlagwort(e): FLASH ; Spin-echo technique ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A multisclice gradient echo sequence (FLASH) was compared with a conventional spin-echo (SE) technique with regard to its value for contrast enhanced brain studies. In 50 patients with contrast enhancing intracranial lesions, MR studies (0.5 Tesla MR tomograph) were performed with SE images (SE 400/30; four images/3.4 min) and FLASH scans (FLASH 315/14, 90°; 15 images/1.4 min) before and after Gd-DTPA. Based on visual and quantitative assessment diagnostic results of postcontrast SE- and FLASH images were equivalent with respect to contrast enhancement, lesion/brain-contrast, lesion/edema-contrast, and lesion delineation. Although image quality generally was excellent on postcontrast FLASH images, susceptibility artifacts were more severe on FLASH scans than on SE images. However, with the exception of postoperative patients with artifacts due to metal remains, diagnostic information was not decreased by artifacts on postcontrast FLASH images. In conclusion, because of the clearly higher efficiency of the multisclice FLASH technique, this pulse sequence offers the opportunity to speed up contrast enhanced brain imaging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02426458
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  • 88
    Digitale Medien
    Digitale Medien
    Mandibular nerve: MR versus CT about 10 proved unusual tumors (1990)
    Springer
    Neuroradiology 32 (1990), S. 492-496 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Nerves, trigeminal ; Parapharyngeal space ; Masticator space ; Magnetic resonance imaging ; Cavernous sinus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 10 patients with symptoms of mandibular neuralgia formed the basis of this study. They were studied by both enhanced CT and MRI. MRI, better than CT, easily permits distinction between intrinsic and extrinsic lesions and detects involvement of the cavernous sinus and meninges. Morever, because of its multiplanar imaging capability, and ability to portray exquisite anatomic details and characteristic tissue signal intensity, MRI is helpful in the evaluation of tumor involvement for biopsy and preoperative planning for these deep tumours.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02426462
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  • 89
    Digitale Medien
    Digitale Medien
    Intraventricular choroid plexus “arachnoid” cyst (1990)
    Springer
    Neuroradiology 32 (1990), S. 523-525 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Arachnoid cyst ; Lateral ventricle ; choroid plexus ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A young women presented with chronic headaches associated with a cyst of the right lateral ventricle. The diagnosis of intraventricular so-called “arachnoid” cyst was supported by CT scan, MRI and stereotactic puncture. MRI was of great value for demonstrating that the cyst was located within the lateral ventricule, that it was delinated by a thin wall adherent to the choroid plexus and that the cyst content was CSF-like.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02426471
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  • 90
    Digitale Medien
    Digitale Medien
    Gd-DTPA enhanced MR imaging in intracranial tuberculosis (1990)
    Springer
    Neuroradiology 32 (1990), S. 19-25 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Tuberculosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Twenty-six patients with intracranial tuberculosis (Tb) (10 with acute meningitis, 5 with chronic meningitis, 5 with meningitic sequelae and 6 with localized tuberculoma(s) were examined with MR before and after Gd-DTPA enhancement (0.1 mmol/kg), using 2.0T superconducting unit, and the images were retrospectively analyzed and compared with CT scans. Without Gd-DTPA enhancement, the MR images were generally insensitive to detection of active meningeal inflammation and granulomas. The signal intensity of granulomas was usually isointense to gray matter on both T1- and T2-weighted images, whether they were associated with diffuse meningitis or presented as localized tuberculoma(s). A few granulomas showed focal hypointensity on T2-weighted images. Calcifications seen on CT of the meningitic sequelae group usually appeared markedly hypointense on all spin-echo sequences. On Gd-DTPA enhanced T1-weighted images, abnormal meningeal enhancement indicating active inflammation was conspicuous, and the granulomas often appeared as conglomerated ring-enhancing nodules, which seems to be characteristic of granulomas. Thin rim enhancement around the suprasellar calcifications were observed in two out of 5 patients with meningitic sequelae. Compared with CT, MR detected a few more ischemic infarcts, hemorrhagic infarcts, meningeal enhancement and granulomas in the acute meningitis group, but missed small calcifications in the basal cisterns well shown on CT in the sequelae group. Otherwise, MR generally matched CT scans. MR imaging appears to be superior to CT in evaluation of active intracranial Tb only if Gd-DTPA is used, while CT is better than MR in evaluating meningitic sequelae with calcification.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593936
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  • 91
    Digitale Medien
    Digitale Medien
    Magnetic resonance evaluation of severe neurological disorders in eclampsia (1990)
    Springer
    Neuroradiology 32 (1990), S. 47-49 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Eclampsia ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A patient with eclampsia and severe but reversible neurological disorders is presented. Initial magnetic resonance imaging (MRI) revealed multiple hyperintense areas throughout the brain and brainstem that were consistent with ischemia and/or edema. Despite these diffuse lesions extending to the brainstem, the patient made a progressive neurological recovery and a follow-up MRI on day 21 demonstrated complete resolution of the hyperintense foci. MRI abnormalities were found to correlate more closely with clinical and electrophysiological data than CT findings.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593941
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  • 92
    Digitale Medien
    Digitale Medien
    The “dense artery sign” — major cerebral artery thromboembolism demonstrated by computed tomography (1990)
    Springer
    Neuroradiology 32 (1990), S. 98-103 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Cerebral infarction ; Thrombembolism ; Computed tomography ; Density quantification ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 4 years review of high resolution thin slice (3–5 mm) computed tomography performed within 24 h after cerebral infarction revealed increased density in a major cerebral artery segment in 28 patients. Arteries affected were the vertebral and basilar artery in 6 and 8 patients, the sphenoid course of the middle cerebral artery in 13 cases and the extracranial internal carotid artery in 1 patient. In 35.7% of cases the so called “dense artery sign” provided earliest evidence of the ensuing infarction documented by CT controls in most patients. Angiography carried out in 8 patients, density caculations in the course of the affected vessel and resolution of the increased density on subsequent CT examinations suggest thrombembolism as the most likely etiology. In the clinical setting of acute stroke increased artery density encompassing the entire vessel diameter may serve as an early indicator of major cerebral artery occlusion and prompt angiographic investigation of a lesion potentially amenable to lysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00588557
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  • 93
    Digitale Medien
    Digitale Medien
    Joubert syndrome: a clinico-radiological study (1990)
    Springer
    Neuroradiology 31 (1990), S. 502-506 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Joubert syndrome ; Developmental abnormalities ; Brain ; CT ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A characteristic malformation of the cerebellum, including dysgenesis of the vermis and enlargement of the fourth ventricle was observed on computed tomography (CT) in 16 children on review of our consecutive material. Seven of these children underwent magnetic resonance imaging (MRI) which showed hypoplasia of the brainstem in addition to cerebellar vermian dysgenesis. One child had, in addition, dysgenesis of the corpus callosum. All these children were developmentally delayed, and many had neonatal breathing abnormalities, congenital retinal dystrophy and supranuclear ocular motor abnormalities. Joubert's syndrome should be suspected in children in whom dysgenesis of the cerebellar vermis and hypoplasia of the brainstem is shown on CT or MRI.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00340131
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  • 94
    Digitale Medien
    Digitale Medien
    Comparing the cost of spinal MR with conventional myelography and radiculography (1990)
    Springer
    Neuroradiology 32 (1990), S. 124-136 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Spinal ; Comparison with myelography, radiculography ; Costs ; Effectiveness
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary All spinal magnetic resonance imaging examinations carried out during a three month period were analysed retrospectively in order to determine the clinical reasons for the scan requests. Technical details of the examinations they received and the clinical profiles formed a data set which revealed 10 separate “Clinical groups” for management purposes. Hardware, salary and expendables were costed as though the imaging unit had been sited within a National Health Service radiology department. A spread sheet was designed capable of calculating costs per patient for a variety of types of working week and of different staffing structures, sensitive to the mixture of clinical groups referred for examination. The spreadsheet also accomodated straight line depreciation for hardware value and interest rates for borrowed capital. A second, prospectively observed, sample of spinal MR examinations was used to improve the accuracy of the timing of the length of patient examinations. Costs were compared with those for patients submitted for myelography and radiculography at the adjacent hospital during the same period. The comparison indicated that spinal MR was less costly than myelography and radiculography. The most important element of the extra cost of myelography related to the need to admit patients to hospital for at least one night for this examination because of the likelihood of headache and other common (though usually minor) complications following lumbar puncture and/or the injection of contrast medium. From the limited information that it was possible to obtain in the period of follow up, it appeared that MR had either been superior or equivalent to myelography or radiculography in all the clinical groups of patients where both could be tested. There were a number of groups in which no myelograms had been requested, presumably because clinical suspicions had pointed toward conditions like tumours, developmental abnormalities and demyelinating diseases in which neurologists and neurosurgeons have already made up their minds about the superiority of MR.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00588562
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  • 95
    Digitale Medien
    Digitale Medien
    Negative scintigraphy with positive magnetic resonance imaging in bone metastases (1990)
    Springer
    Skeletal radiology 19 (1990), S. 113-116 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Magnetic resonance imaging ; Metastases ; Scintigraphy ; Radionuclide ; Bone scan
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report three patients with known primary tumor in whom radionuclide skeletal imaging for metastatic disease was normal with or without clinical symptomatology referable to this area. Magnetic resonance imaging (MRI) of the spine demonstrated focal areas of abnormal signal intensity in the vertebral bodies of these patients. In all three patients, biopsy confirmed metastatic disease. All the patients received radiation or chemotherapy depending upon the etiology. These preliminary data suggest that MR imaging may be useful in evaluating patients with known primary tumor in whom clinical suspicion persists despite a negative radionuclide bone scan.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00197616
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  • 96
    Digitale Medien
    Digitale Medien
    Magnetic resonance imaging in acute and chronic rotator cuff tears (1990)
    Springer
    Skeletal radiology 19 (1990), S. 109-111 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Magnetic resonance imaging ; Acute and chronic rotator cuff tears
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Magnetic resonance imaging has been assessed in patients with acute rotator cuff tears and normal radiographs (9 cases) and those with chronic tears and changes of cuff arthropathy (9 cases). All images were obtained using a low field strength system (FONAR 0.3 T). Particular attention was placed on the appearances of the tendon and the cuff muscles themselves. Six complete acute tears were clearly identified, but MRI failed to demonstrate two partial tears. Muscle bulk was preserved in all patients in this group. In contrast, all patients with cuff arthropathy had complete tears of the supraspinatus tendon with marked tendon retraction and associated muscle atrophy: these changes precluded primary surgical repair. MRI should be used to assess muscle atrophy preoperatively in those patients with acute tears. When plain radiographs demonstrate cuff arthropathy, the MRI appearances are predictable and primary repair is unlikely to be successful. Further imaging is therefore not indicated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00197615
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  • 97
    Digitale Medien
    Digitale Medien
    Magnetic resonance imaging in the evaluation of sequelae after tibial plateau fractures (1990)
    Springer
    Skeletal radiology 19 (1990), S. 127-129 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Tibial fractures ; Tibial plateau ; Articular depression ; Fibro-cartilage ; Magnetic resonance imaging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Nine knees with persistent radiographic depression of the articular surface after tibial plateau fractures treated by traction and early knee motion were examined using magnetic resonance imaging (MRI). The MRI examinations demonstrated that the radiographic bone defects were filled up with different tissues, which we interpreted as cartilage, fibrous tissue and synovial plica. The type of tissue in the bone defect did not seem to affect the functional capabilities of the knee. However, a demonstrable thin cover of tissue, with the signal-intensity of cartilage, over the defect, seemed to be associated with an excellent functional result.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00197620
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  • 98
    Digitale Medien
    Digitale Medien
    Musculoskeletal haemangiomas: comparison of MRI with CT (1990)
    Springer
    Skeletal radiology 19 (1990), S. 251-258 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Musculoskeletal haemangiomas ; Magnetic resonance imaging ; Computed tomography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract MRI and CT findings were reviewed from 11 patients with musculoskeletal haemangiomas. With MRI, morphological characteristics and extent of haemangiomas were optimally demonstrated on T2-weighted spin echo scans. High-resolution contrast-enhanced CT provided equivalent information regarding lesional characteristics and extent for small, localized haemangiomas. In CT evaluation of the extent of large haemangiomas, the radiation dose, transaxial scan plane, amount of intravenous contrast medium required and the necessity for correct timing of post-contrast scans became limiting factors. For such lesions, particularly those extending into the trunk, MRI supplemented by a plain radiograph is the optimum method of evaluation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00191666
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  • 99
    Digitale Medien
    Digitale Medien
    MRI demonstration of hypertrophic articular cartilage repair in osteoarthritis (1990)
    Springer
    Skeletal radiology 19 (1990), S. 335-339 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Magnetic resonance imaging ; Knee ; Osteoarthritis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Transection of the anterior cruciate ligament in the dog produces changes in the unstable joint typical of osteoarthritis, although full-thickness cartilage ulceration is rare. Information concerning the late fate of the cartilage after transection is meager. In the present study magnetic resonance imaging (MRI) was used to evaluate cartilage abnormalities 3 years after transection. Plain radiographs of the osteoarthritic and contralateral knees were obtained serially. MRI was performed 3 years after anterior cruciate ligament transection, at which time all three animals exhibited knee instability. Radiographs of the osteoarthritic knees showed osteophytes and subchondral sclerosis with progression between 2 and 3 years. On MRI, articular cartilage margins in the knee were indistinct, and the cartilage was thicker than that in the contralateral knee (maximum difference= 2.7 mm). This increase in thickness is consistent with biochemical data from dogs killed up to 64 weeks after creation of knee instability, which showed marked increases in cartilage bulk and in proteoglycan synthesis and concentration. The findings emphasize that increased matrix synthesis after anterior cruciate ligament transection leads to functional cartilage repair sustained even in the presence of persistent alteration of joint mechanics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00193086
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  • 100
    Digitale Medien
    Digitale Medien
    Panhypopituitarism without diabetes insipidus: Magnetic resonance imaging of pituitary stalk transection (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 235-236 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Panhypopituitarism ; Magnetic resonance imaging ; Empty sella
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 13 year 2 month old girl was referred with panhypopituitarism without diabetes insipidus. Magnetic resonance imaging demonstrated transection of the pituitary stalk, a hypoplastic pituitary gland, and the presence of an ectopic neurohypophysis located at the proximal stump of the transected stalk.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02106279
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