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  • Articles: DFG German National Licenses  (155)
  • 2000-2004  (155)
  • 1890-1899
  • 1820-1829
  • Keywords  (78)
  • Prognosis  (77)
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  • Articles: DFG German National Licenses  (155)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 436 (2000), S. 102-108 
    ISSN: 1432-2307
    Keywords: Key words Oral ; Squamous cell carcinoma ; Proliferation ; Apoptosis ; Tumour suppressor gene ; Oncogene ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Tumour progression is characterised by an imbalance between cell proliferation and apoptosis. The aim of our study was to estimate the importance of proliferation and apoptosis associated parameters in primary squamous cell carcinomas (SCCs) of the oral cavity and oropharynx. For determination of apoptosis, the enzymatic labelling of DNA fragmentation with a terminal transferase reaction was used in 156 tissue samples of 107 patients, including corresponding lymph-node metastases in nine cases. P53, bcl-2, and Ki-67 were determined immunohistologically. P53 was detectable in 50.5% of the cases. Positive staining was associated significantly with decreased apoptosis (P〈0.003). Bcl-2 was upregulated in 31.8% of the cases depending on the tumour grading (P〈0.001) and correlated negatively with apoptosis (P〈0.001). Proliferation (P〈0.006) and apoptosis (P〈0.03) were enhanced in larger tumours, though a direct correlation between these two parameters was not proven. Nevertheless, in contrast to the conventional tumour staging and grading, neither the expression of p53 or bcl-2 nor the apoptosis or Ki-67 measurements were able to predict survival or recurrence-free survival of the patients suffering from a SCC in the oral cavity or oropharynx. Our observations suggest that the function of wild-type p53 to induce apoptosis is lost in at least half of the SCCs under study and that the physiological function of bcl-2 as potent inhibitor of apoptosis is widely preserved in oral SCC.
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  • 2
    ISSN: 1432-2307
    Keywords: Key words CD44 ; Adhesion molecules ; Prognosis ; Soft tissue sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Recent studies have shown that expression of alternatively splicing variants of CD44 is correlated with prognosis for several kinds of malignant tumors. However, little is known about the expression of CD44 standard and variant isoforms in soft tissue sarcomas. In this study 47 cases of soft tissue sarcoma [18 malignant fibrous histiocytomas (MFHs), 13 synovial sarcomas (SSs), 7 malignant schwannomas (MSs), and 9 liposarcomas (LSs)] were examined immunohistochemically. The monoclonal antibodies to the standard form of CD44 (CD44H) and variant exons of CD44v3, 4, 5, 6, 7, 9, and v10 were used. We analyzed the membranous expression pattern of CD44H and CD44 variant exons and assessed the relation between expression of CD44s and metastasis-free survival rates (MFSR) of patients with soft tissue sarcoma. A few sarcomas expressed CD44v3 (2/47) and v7 (2/47), but none of the sarcomas expressed CD44v10. CD44v4 (5/47), v5 (4/47), v6 (10/47), and v9 (9/47) are relatively common types of variant isoforms in soft tissue sarcomas. Expression of CD44v6 is more frequently detected in high-grade than in low-grade tumors. CD44v6 or CD44v9 expression was correlated with metastasis-free survival of patients with soft tissue sarcomas.
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  • 3
    ISSN: 1432-2307
    Keywords: Keywords AgNORs ; Standardised AgNOR analysis ; Parathyroid tumour ; Proliferation ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Prediction of evolution of secondary hyperplasia and tumours of the parathyroid glands is still a problem in histopathology. To assess whether the quantity of silver-stained nucleolar organiser region (AgNOR) proteins might be used as a prognostic tool in parathyroid pathology, a standardised AgNOR analysis has been performed on 19 cases of parathyroid hyperplasia caused by secondary hyperparathyroidism (PH), 8 cases of adenoma (PA) and 10 cases of carcinoma (PC). Clinico-pathological data and follow-up information were available. On formalin-fixed and paraffin-embedded sections, the visualisation and quantification of AgNORs were achieved according to the 1995 guidelines of the Committee on AgNOR Quantification. Then, the mean area (square micrometres) of AgNORs per nucleus (NORA) was evaluated by means of an image analyser and specific softwares. After testing the normal distribution of NORA values, statistical parametric tests were utilised; Kaplan-Meier and Cox multivariate analyses were also performed. In parathyroid lesions, a progressive increase of mean NORA values was observed from PH (2.895 µm2; SE 0.171) through PA (3.638 µm2; SE 0.125) to PC (4.701 µm2; SE 0.179); these differences were highly significant (P〈0.001), although some degree of overlap was found among single NORA values. A significantly higher mean NORA value was revealed in PC with distant metastases than was noted in cases with no current clinical evidence of disease progression. Furthermore, a significantly (P〈0.001) higher mean NORA value was encountered in the group of PH with recurrences (3.600 µm2; SE 0.106) than in nonrecurrent PH (2.261 µm2; SE 0.087). Multivariate analyses indicated that the NORA value was an independent prognostic parameter determining the risk of recurrence in PH. We suggest that AgNOR quantity may be a promising additional tool for predicting the biological behaviour of parathyroid lesions.
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  • 4
    ISSN: 1432-2129
    Keywords: Schlüsselwörter ; Kopfschmerz ; Kinder ; Akuttherapie ; Flupirtin ; Paracetamol ; Keywords ; Children ; Acute treatment ; Tension-type headache ; Flupirtine ; Paracetamol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: About 10% of all schoolchil- dren are suffering from migraine and 50% from tension-type headache. Headache of acute onset usually will be treated with analgesic substances like paracetamol, acetylsalicylic acid or ibuprofen, the first one being the reference drug for tension-type headache in childhood. In case of lacking improvement or side-effects there is demand for an alternative safe substance for the acute analgesic therapy. Methods: In a double-blind randomised investigation flupirtine and paracetamol were given in two consecutive attacks of episodic tension-type headache. 30 children, 6–12 years old, were included. Dosage was determined according to age and weight. The children documented the acute headache intensity and duration in a special diary. Results: Headache intensity was reduced during 2 h after intake in 89% of the 19 children treated. The reduction was 6,5 to 3,1 for flupirtine and 6,9 to 3,3/10 for paracetamol. There was no statistically significant difference between the two substances. Relevant side-effects could not be observed. Conclusion: Flupirtine has shown a convincing clinical effect treating acute episodic tension-type headache for children. The substance was well tolerated by the patients. In addition, flupirtine provides a high degree of safety.
    Notes: Zusammenfassung Hintergrund: Etwa 10% aller Schulkinder leiden nach neueren deutschen epidemiologischen Untersuchungen zumindest gelegentlich an Migräne und etwa 50% an Kopfschmerzen vom Spannungstyp. Häufig nehmen sie bei Spannungskopfschmerzen analgetische Monosubstanzen wie Paracetamol, Azetylsalizylsäure oder Ibuprofen ein. Bei nicht ausreichender Wirkung bzw. Unverträglichkeit besteht Bedarf nach weiteren Substanzen für die Akutanwendung. Methode: In einer doppelblindrandomisierten und gekreuzten Anordnung wurden Paracetamol bzw. das analgetisch und muskelrelaxierend wirksame Flupirtin 30 6- bis 12jährigen Kindern für 2 episodische Spannungskopfschmerzattacken angeboten. 10 Kinder benötigten nach dem Erstkontakt keine Medikation mehr, 1 Kind lehnte die Einnahme grundsätzlich ab. Ergebnisse: Die Kopfschmerzstärke verringerte sich laut Kopfschmerztagebuch innerhalb von 2 h nach der Einnahme auf einer numerischen Schmerzskala (0–10) von 6,5 auf 3,1 unter Flupirtin und von 6,9 auf 3,3 unter Paracetamol bei 89% der verbliebenen 19 Kinder. Statistisch signifikante Unterschiede zwischen beiden Substanzen bestanden nicht. Als Nebenwirkung trat 1-mal Erbrechen unter Paracetamol auf. Schlussfolgerung: Flupirtin hat sich in der Akutphase von episodischen Spannungskopfschmerzen beim Kind bewährt. Es verfügt über eine gute Verträglichkeit. Im Vergleich zu Paracetamol scheint v.a. bei akzidenteller Überdosierung eine größere Sicherheit zu bestehen.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 14 (2000), S. 5-9 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter ; Periphere Nervenläsionen ; Begutachtung ; Neuropathie ; Minderung der Erwerbs- fähigkeit ; Keywords ; Peripheral nerve lesion ; Neuralgia-physiopathology ; Causalgia-physiopathology ; Loss of earning capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Introduction: The loss of functional capacity by peripheral nerve lesion is easy to be estimated: A certain neurologic dysfunction results in a characteristic reduction of the former individual capacity. In contrast, the effect of accompanying pain to every-day life and working ability is not known exactly. In this study, we compared the results of judgement in nerve lesions under the circumstances of additional pain syndromes. Methods: From January 1994 until Dezember 1998 we saw 57 patients with peripheral nerve lesions, part of them with an additional pain syndrome. Beside conventional neurological examination a detailed pain analysis has been done. Results: Lesions of the median or ulnar nerves showed regularly disturbences in neurological functions (10/14 for the mediane nerve, 13/16 for the ulnar nerve). Astonishing is the fact, that serious pain after nerve lesion only occurs in cases of partial nerve lesion. We saw neuralgias in 6 patients with ulnar neuropathy, in three cases of median nerve lesions we could see severe neuralgia (causalgia we found in 3 cases of ulnar neuropathy, in 6 cases after Median Nerve lesion). Patients with a lesion of the central plexus brachialis showed in 10 of 11 cases an additional pain syndrome. Other nerves have been affected more rarely. For the judgement of the loss of earning capacity we saw an additional pain related diminuition of at least 10% compared to those patients without pain problems. Conclusions: The common grading scales for peripheral nerve lesions are not suitable in cases accompanied by an additional pain syndrome. Beside a functional deficit the effect of severe pain in these patients has to be estimated. On an average, patients with addtitional pain-problems get a 10% extended loss of earning capacity, even more in particular cases.
    Notes: Zusammenfassung Fragestellung: Anhand retrospektiver Daten sollten geeignete Bewertungsgrundlagen für die Begutachtung peripherer Nervenläsionen erarbeitet werden. Methode: Von Januar 1994 bis Dezember 1998 wurden insgesamt 57 Patienten (36 männlich, 21 weiblich, Durchschnittsalter 33,9 Jahre) mit dieser Fragestellung im Rahmen einer Begutachtung untersucht. Ursächlich lagen traumatische Ereignisse bei 39 (68%), postoperative Störungen bei 14 und andere Schädigungen bei 4 Patienten zugrunde. Ergebnisse: Beim N. medianus und N. ulnaris (beispielhaft) überwogen die Schmerzzustände bei inkompletten Läsionen. Neuralgien fanden sich bei 3 bzw. 6 Patienten mit N.-medianus- bzw. N.-ulnaris-Läsion. Eine Kausalgie fand sich bei 6 bzw. 3 Patienten. Mit Ausnahme von Armplexusläsionen waren andere Nerven seltener betroffen. Diese Situation wurde mit einer durchschnittlich um 10% höher gelegenen Einschätzung der Leistungseinbuße berücksichtigt, wenn gleichzeitig Schmerzen vorlagen. Schlussfolgerungen: Die für die reine Funktionseinbuße gültigen Skalen zur Bemessung peripherer Nervenläsionen können für die Begutachtung von Schmerzsyndromen nur bedingt herangezogen werden. Meist führen Schmerzen zu einer um durchschnittlich 10% höheren Einschränkung der Erwerbsfähigkeit (MdE), allerdings sind in manchen Fällen auch größere Einbußen denkbar.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 14 (2000), S. 10-17 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter ; Schmerzerkrankungen ; Krankheitsschwere ; Chronifizierungsstadien ; Mainzer Stadienmodell ; Keywords ; Chronic pain ; Grading procedure ; Mainz Pain Staging System
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Introduction: Chronic pain is an individually variable experience, incorporating physical, psychological and social dimensions. Chronic pain occurs in a broad spectrum of severity; therefore, a grading procedure is of crucial importance in clinical research and in epidemiologic studies. The Mainz Pain Staging System is an interview-administered, multi-dimensional measure of chronic pain severity. The system suggests grading chronic pain in terms of 4 axes: time (persistence), spreading of pain site, medication use, and health care utilization. The whole scale consist of 10 items. The resulting score is used to classify the pain problem in three stages (I, II, III). Analysing the broader validity and parametric properties of the staging system is the purpose of the present study. Methods: The staging system and psychosocial data were administered to 542 consecutive patients of different diagnoses who attended one of six pain clinics in the year 1995/96. In a time period of 3 months since first contact, treatment procedures were registered. Three months after first contact patients rated the effectiveness of treatment concerning reduction of pain intensity. Results: According to the criteria of the staging system 25% of the sample belonged to each stage I and stage III, whereas 50% were classified to stage II. As a measure of validity, chronic pain status demonstrated significant correlation with psychological impairment, disability and time off work, whereas there was no correlation to pain intensity and persistence of pain. Surprisingly we found no difference in amount and quality of treatment between patients who were graded as severe pain patients (stage III) and the other stages. Furthermore, effectiveness of treatment also did not differ between the three stages. We made several proposals for optimizing the staging system. Conclusion: Given the high prevalence of recurrent and chronic pain as well as the broadness of severity, an important issue on further research is identification of factors which influence the chronification process. For this purpose improved measures of graded classification of pain status are needed.
    Notes: Zusammenfassung Hintergrund: Die Beschreibung von Schmerzsyndromen ist durch eine Diagnose allein nicht ausreichend gewährleistet; erst die Angabe der Krankheitsschwere ermöglicht sowohl die Indikation der entsprechenden Behandlung als auch eine Vergleichbarkeit von Fällen. Patienten und Methode: In einer multizentrischen Studie wurde bei 542 Patienten das aus der Mainzer Arbeitsgruppe um Gerbershagen 1986 vorgestellte Stadienmodell der Chronifizierung ermittelt und in Abhängigkeit von Patienten- und Diagnosemerkmalen sowie im Hinblick auf seine parametrischen Eigenschaften analysiert. Ergebnisse und Diskussionen: Die Ergebnisse der Untersuchung bestätigen die gute Validität des Verfahrens im Hinblick auf seine Unabhängigkeit von schmerzspezifischen Parametern. Es besteht theoriegemäß eine gute Übereinstimmung zum Ausmaß der emotionalen Befindlichkeit (Depression), zur subjektiven Beeinträchtigung und zum Ausmaß der Arbeitsunfähigkeit. Die Ergebnisse zeigen auch Ansätze für Verbesserungsmöglichkeiten. Einige der berücksichtigten Kriterien sind vermutlich überflüssig, während der zusätzliche Einbezug des subjektiven Beeinträchtigungserlebens notwendig erscheint. Ob ein übergreifendes Graduierungsmodell für verschiedene Schmerzerkrankungen überhaupt valide sein kann, muss eine weitergehende Analyse zeigen.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 14 (2000), S. 29-32 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter ; Flupirtin ; Langzeitbehandlung ; Keywords ; Flupirtine ; Long-term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Case report: The worker O.H., born in 1959, had in 1992 an accident as a car driver. His injuries were a severe acceleration trauma of the cervical spine with rupture of the longitudinal ligament, a concussion of the brain, and an eye injury. Therapy: After the emergency treatment, the multidisciplinary management could not resolve the persistent musculoskeletal cervicocephal and -brachial pain syndrome. The long-term application of 100 mg flupirtine tid improved the chronic pain state for 50–60%. Due to this regimen, the patient could be rehabilitated.
    Notes: Zusammenfassung Fallbericht: Der 1959 geborene Arbeiter (O.H.) erlitt im September 1992 als PKW-Fahrer einen Wegeunfall mit schwerem HWS-Trauma, Commotio cerebri, Oberlidverletzung und Augapfelprellung rechts. Danach persistierten zervikozephale und zervikobrachiale Schmerzen. Behandlung: Nach der Evaluation verschiedener Therapieverfahren erfolgte die Einstellung auf durchschnittlich 3-mal 100 mg Flupirtin täglich mit dem Ergebnis einer durchschnittlich 50- bis 60%igen Linderung starker, belastungsabhängiger Dauerschmerzen. Dank dieser Medikation konnte der Betroffene beruflich integriert werden.
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  • 8
    ISSN: 1432-2102
    Keywords: Schlüsselwörter ; Mehrzeilen-CT ; Elektronenstrahl-CT ; Koronar-Screening ; CT Angiographie ; Koronarsklerose ; Keywords ; Multidetector CT ; Electron beam CT ; Coronary screening ; CT angiography ; Coronary atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: Multirow-detector-spiral-CT (MSCT) allows for 250 ms effective exposure time. The purpose of this study was to demonstrate the possibilities and limitations of this CT technology for non enhanced and contrast enhanced investigation of the coronary arteries. Methods: Investigation of the coronary arteries without contrast medium for quantification of coronary calcifications was performed in an obese patient (140 kg) with MSCT and electron beam CT (EBCT). In 56 patients contrast enhanced CT angiography of the coronary arteries was performed to determine image quality depending on the heart rate. Results: In the obese patient superior image quality could be achieved with MSCT allowing for reliable quantification of coronary calcifications. With MSCT angiography of the coronary arteries good image quality was achieved in patients with a heart rate of 59±8 beats per minute. Conclusion: Even if there are limitations in patients with higher heart rates with an effective exposure time of 250 ms MSCT has clear advantage of image quality in the assessment of non enhanced and contrast enhanced coronary arteries.
    Notes: Zusammenfassung Fragestellung: Mit dem Mehrzeilendetektorspiral-CT (MSCT) sind effektive Aufnahmezeiten von 250 ms möglich. Die Möglichkeiten und Grenzen dieser CT-Technologie zur nativen und kontrastverstärkten Untersuchung der Koronargefäße sollen in dieser Arbeit dargestellt werden. Methode: Die native Untersuchung der Koronargefäße zur Quantifizierung von Koronarkalk wurde bei einem Patienten mit Adipositas (140 kg) mit dem Elektronenstrahl-CT (EBCT) und dem MSCT vorgenommen. Bei 56 Patienten wurde eine kontrastverstärkte MSCT-Angiographie der Koronargefäße vorgenommen und festgestellt, bei welcher Herzfrequenz eine diagnostisch ausreichende Bildqualität zu erreichen ist. Ergebnisse: Bei der Untersuchung des Patienten mit Adipositas konnte mit dem MSCT eine erheblich bessere Bildqualität erreicht werden, die eine Quantifizierung von Koronarkalk erheblich erleichterte. Mit der MSCT-Angiographie der Koronargefäße konnte bei einer Herzfrequenz von 59±8 Schlägen/min eine diagnostisch gute Bildqualität erreicht werden. Schlussfolgerung: Auch wenn mit einer effektiven Aufnahmezeit von 250 ms Limitationen bei höheren Herzfrequenzen zu erwarten sind, können mit dem MSCT entscheidende Vorteile in der Bildqualität in der nativen und kontrastverstärkten Untersuchung der Koronargefäße erreicht werden.
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  • 9
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Apoptose ; Proliferation ; Hämatopoetischer Zellumsatz ; Topoisomerase II α ; PCNA ; Chronische myeloproliferative Erkrankungen ; Prognose ; Reaktive Läsionen ; Key words Apoptosis ; Proliferation ; Hematopoietic turnover index ; Topoisomerase II α ; PCNA ; Chronic myeloproliferative disorders ; Prognosis ; Reactive lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Apoptosis and proliferation are important regulators of normal development and homeostasis in the bone marrow. Therefore, dynamics of hematopoiesis is mainly defined by these two parameters. However, since only few data are available from previous studies, we performed a retrospective analysis to elucidate some aspects of this complex pathomechanism. A total of 400 patients with chronic myeloproliferative disorders (CMPDs) and corresponding reactive bone marrow lesions were enrolled into this study. Apoptosis was detected in bone marrow tissue by the ISEL-technique and topoisomerase II α expression was demonstrated by the monoclonal antibody Ki-S1. Furthermore, by determination of the proliferating-cell nuclear antigen labeling (PCNA) index, we were able to calculate the proportion of cells in the G2/M phase, because both nuclear antigens are expressed in different phases of the cell cycle. Patients with IMF, PV, and ET revealed a normal range of apoptosis, whereas in chronic myeloid leukemia (CML) a significant increase could be observed. On the other hand, IMF and PV were characterized by a raised proliferative activity. Dynamics of hematopoiesis was assessed by calculation of the so called hematopoietic turnover index. In CML and reactive lesions no alterations of this parameter were detectable, but IMF and PV showed a significant increase. Survival analysis disclosed a relevant worsening of life expectancy for patients with reduced apoptosis and proliferation. In conclusion, our in-situ results confirm and extend previous experimental data on hematopoietic cell kinetics. In this context, a greater regenerative capacity of hematopoiesis may be reflected by an increased rate of apoptosis and/or proliferation and therefore is associated with a more favorable outcome.
    Notes: Zusammenfassung Apoptose und Proliferation stellen im Rahmen einer funktionsgerechten Regelung der Hämatopoese einen integralen Bestandteil für die Aufrechterhaltung des zellulären Gleichgewichts im Knochenmark dar. Insofern ist die Dynamik des hämatopoetischen Zellumsatzes durch diese beiden Parameter gekennzeichnet. Da weiterführende Untersuchungen in dieser Hinsicht lediglich vereinzelt am Knochenmark durchgeführt worden sind, haben wir im Rahmen einer retrospektiven Analyse versucht, einige Aspekte dieses komplexen Mechanismus zu beleuchten. Insgesamt wurden 400 Patienten mit chronischen myeloproliferativen Erkrankungen (CMPE) sowie korrespondierenden reaktiven Veränderungen in die Untersuchung aufgenommen. Neben dem direkten Nachweis der Apoptose im Knochenmark durch die ISEL-Technik haben wir die Topoisomerase II α Expression mittels des monoklonalen Antikörpers Ki-S1 gemessen. Zusätzlich konnten wir durch die Bestimmung der PCNA-Markierung aufgrund der Zellzyklus-spezifischen Färbereaktion beider nukleärer Antigene den Anteil der in G2-/M-Phase befindlichen Zellen ermitteln. Während die IMF, die PV sowie die ET eine im Normbereich liegende Apoptoserate erkennen ließen, war dieser Wert bei der CML signifikant erhöht. Auf der anderen Seite wiesen IMF und PV eine deutlich gesteigerte proliferative Aktivität im Knochenmark auf. Bei der Berechnung eines hämatopoetischen Zellumsatz Index (HZI) zeigten diese beiden CMPE-Subtypen einen signifikanten Anstieg, wohingegen bei der CML sowie den reaktiven Läsionen keine relevante Verschiebung dieses Parameters festzustellen war. Im Rahmen prognostischer Analysen hatten IMF und PV Patienten mit reduzierter Proliferation und Apoptoserate jeweils eine signifikant kürzere Überlebenszeit. Unsere in-situ Ergebnisse erweitern und bestätigen vorausgegangene experimentelle Studien zur hämatopoetischen Zellkinetik. Darüber hinaus lassen sich aus unseren Daten prognostische Überlegungen ableiten, da insbesondere bei der PV und IMF Apoptose und Proliferation signifikanten Einfluß auf das Überleben der Patienten hatten. In diesem Zusammenhang spiegelt eine vermehrte Apoptose- und Proliferationsrate im Knochenmark offenbar eine größere regenerative Kapazität der Hämatopoese wieder und könnte daher für einen günstigeren Verlauf verantwortlich gemacht werden.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 21 (2000), S. 456-459 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Undifferenziertes kleinzelliges Hepatoblastom ; Immunhistochemie ; Keywords Undifferentiated small-cell hepatoblastoma ; Immunohistochemistry ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Undifferentiated small-cell hepatoblastoma (HB) is a rare malignant tumor of childhood. The cell of origin is supposed to be a pluripotential, probably entodermal, stem-cell. Differential diagnosis of this type of HB is difficult among the group of small round and blue cell malignant tumors of children. The immunohistochemically determined coexpression of cytokeratin 8, 18, and 19 and of vimentin and actin, regularly in the absence of α-fetoprotein expression may be diagnostically helpful. We present the case of an undifferentiated small-cell HB of a 15-month-old girl with agenesis of the right kidney. As morphological peculiarity the tumor presented disseminated histiocytic giant cells.
    Notes: Zusammenfassung Undifferenzierte kleinzellige Hepatoblastome (HB) zählen zu den seltenen malignen Tumoren der Leber im Kindesalter. Da der Tumor in der Regel kein α-Fetoprotein exprimiert, ist der Nachweis von Zytokeratin 8, 18 und 19 sowie Vimentin und Aktin diagnostisch wegweisend. Als Ausgangszelle wird eine pluripotente, wohl entodermale Stammzelle vermutet. In der Gruppe der klein-, rund- und blauzelligen malignen Tumoren des Kindesalters bietet diese Variante des HB differenzialdiagnostische Schwierigkeiten. Wir berichten über ein undifferenziertes kleinzelliges HB eines 15 Monate alten weiblichen Kleinkindes mit Agenesie der rechten Niere. Als morphologische Besonderheit des Tumors werden disseminierte histiozytäre Riesenzellen beschrieben.
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  • 11
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Gastrointestinaltrakt ; Karzinoid ; Neuroendokrine Tumoren ; DNA-Zytophotometrie ; Prognose ; Key words Gastrointestinal tract ; Carcinoid ; Neuroendocrine tumors ; DNA cytophotometry ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A total of 123 manifestations (97 primary tumours and 26 metastases) of neuroendocrine tumours of the gastrointestinal tract observed in 95 patients was investigated for the prognostic value of clinical, histological and DNA cytophotometric parameters. Metastases almost exclusively occurred among ileal carcinoids, which also were responsible for all 14 cases of lethal outcome observed during the follow-up period of mean 42 months. Aneuploid DNA values could be determined significantly more frequently among ileal than in non-ileal carcinoids and showed – upon analysis of the total group of gastrointestinal neuroendocrine tumours – a significant correlation to lethal course of disease. In addition, among 18 cases with primary and secondary carcinoid manifestations available for DNA cytophotometry, an association between the DNA content of metastatic neuroendocrine tumours and prognosis came to light. When applicated to the group of ileal neoplasms, however, the parameter DNA content did not allow a better prognostic assessment.
    Notes: Zusammenfassung Untersucht wurden 123 Manifestationen (97 Primärtumoren und 26 Metastasen) von bei 95 Patienten beobachteten neuroendokrinen (NE-)Tumoren des Gastrointestinaltrakts auf die prognostische Bedeutung verschiedener klinischer, histologischer und DNA-zytophotometrischer Parameter. Metastasen traten fast ausschließlich bei ilealen Karzinoiden auf, denen auch sämtliche 14 während der durchschnittlichen Nachbeobachtungszeit von 42 Monaten aufgetretenen letalen Erkrankungsverläufe zuzuordnen waren. Aneuploide DNA-Verteilungsmuster wurden signifikant häufiger bei ilealen als bei nichtilealen Karzinoiden angetroffen und waren – bezogen auf die Gesamtgruppe – signifikant mit tödlichem Krankheitsausgang korreliert. Darüber hinaus zeigte sich bei 18 Fällen mit DNA-zytophotometrisch auswertbaren primären und sekundären Karzinoidmanifestationen eine Assoziation zwischen dem DNA-Histogrammtyp metastatischer Karzinoide und der Prognose. Innerhalb der Gruppe der Ileumtumoren erlaubte der Parameter DNA-Gehalt aber keine Verbesserung der Prognoseabschätzung.
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  • 12
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    Journal of cancer research and clinical oncology 126 (2000), S. 48-52 
    ISSN: 1432-1335
    Keywords: Key words Enzyme-linked immunosorbent assay ; p53 protein ; WAF1 protein ; Lung cancer ; Prognosis ; AbbreviationsNSCLC non-small-cell lung cancer ; RR relative risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: p21WAF1, a cyclin-dependent kinase inhibitor, is an important mediator of the cell-cycle arrest and tumor suppression induced by the protein p53. Although alterations of the p53 gene and its overexpression are frequent in most malignancies, including non-small-cell lung cancer (NSCLC), and may be associated with poor patient prognosis, the clinical utility of p21WAF1 expression in NSCLC has not been established. Methods: We have used a commercial enzyme-linked immunosorbent assay (ELISA) kit for p21WAF1 to test soluble extracts of 54 NSCLC specimens with known clinicopathological properties. Results: There was no correlation between p21WAF1 and p53 concentrations, the latter being determined by a time-resolved immunofluorometric assay developed in-house. Furthermore, p21WAF1 levels were not associated with patient age, tumor/node/metastasis (TNM) stage, lymph node metastasis, histological grade or type, or smoking history, in Mann-Whitney analysis. χ2-tests, based on cutoffs equal to the 25th, 50th, or 75th percentiles of the p21WAF1 distribution, similarly did not reveal any statistically significant associations between p21WAF1 and other clinicopathological variables. Because of the small number of patients and the median follow-up of only 18 months, a meaningful survival analysis could not be performed. Conclusion: In summary, this preliminary study suggests that ELISA-quantified p21WAF1 levels in NSCLC extracts are weaker than p53 in terms of prognostic value and do not contribute to the further subclassification of patients.
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  • 13
    ISSN: 1432-1335
    Keywords: Key words erbB-3 ; Colorectal carcinoma ; Survival ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background/aims: The family of erbB receptors includes four transmembrane glycoproteins with tyrosine kinase activity. These receptors are widely expressed in normal tissues, but they also have been implicated in the development of several human adenocarcinomas. c-erbB-3/HER-3 has been detected to a greater or lesser extent in many tissues from the digestive, urinary, reproductive and respiratory tracts. The overexpression of c-erbB-3/HER-3 protein has also been shown in 53%–88% of colorectal adenocarcinomas. In this study we investigated the expression of the c-erbB-3/HER-3 gene product in colorectal tumour samples, and compared the results obtained with several clinicopathological parameters, including the survival of patients. Methods: Paraffin-embedded tissue sections were analysed immunohistochemically, using monoclonal antibody RTJ1 to human erbB-3 protein. Antibody RTJ1 specificity was confirmed by immunoprecipitation followed by Western blotting analysis. Amplification of the erbB-3 oncogene was tested by dot-blot hybridization. Results: Adenocarcinomas of the colon were positive for erbB-3 protein in 78% of samples examined. Dot-blot analysis showed no amplification of the erbB-3 gene in colon adenocarcinomas. Statistical analysis showed that patients with tumours that could not be stained for erbB-3 protein survived significantly longer (P 〈 0.05) than patients with tumours staining positive for the erbB-3 protein. A Cox proportional-hazards model with stepwise variable selection identified age, sex and erbB-3 expression as important prognostic factors. Conclusion: These findings demonstrate that erbB-3 protein expression could serve as a prognostic factor in colorectal malignancies.
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  • 14
    ISSN: 1433-0385
    Keywords: Schlüsselwörter: Inkontinenz ; Rectumcarcinom ; Manometrie ; Prognose ; Anus. ; Keywords: Incontinence ; Rectal cancer ; Anorectal manometry ; Prognosis ; Anus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Aim: To determine clinical and physiologic parameters enabling the prognosis of continence after protective ileostomy closure secondary to rectal resection for rectal cancer. Method: Patients who had undergone rectal resection (n = 65, of whom 24 had had radiochemotherapy) were evaluated by clinical examination, anorectal manometry and orthograde contrast enema before ileostomy closure. Continence was evaluated by clinical findings 91 ± 52 weeks after stoma closure with the help of standardized questionaires and classified according to the Wexner continence score. The relationship between findings before stoma closure and continence score was calculated with Pearson's correlation coefficient. Results: Correlations were found to be significant between the continence score and the level of anastomosis (r = –0.58, p 〈 0.001), median resting pressure (r = –0.52, p 〈 0.001), rectal compliance (r = –0.43, p 〈 0.001). Additionally, radiochemotherapy impairs continence (p = 0.0001). Correlations were not significant between continence and functional sphincter length, squeeze pressure, threshold for perception, urge and maximal tolerable volume, and continence for semiliquid contrast medium. Conclusion: Incontinence after rectum resection is multifactorial: the level of anastomosis, resting pressure, rectal compliance and radiochemotherapy all play a dominant role. Based on these findings, the continence score can be calculated before closure of a diverting ileostomy by applying multivariate analysis with the help of the following formula: Continence score = 18.23–0.94 · level of anastomosis – 0.18 · resting pressure + 3.72 · radiochemotherapy.
    Notes: Zusammenfassung. Ziel dieser Studie war eine Evaluation von klinischen und physiologischen Parametern zur Vorhersage des Kontinenzgrades nach Rückverlagerung der protektiven Loop-Ileostomie nach Rectumresektion wegen eines Carcinoms. Methode: 65 Patienten wurden klinisch mittels anorectaler Manometrie und orthograder Röntgenkontrastmitteldarstellung vor der Ileostomieresektion untersucht. Bei 24 Patienten war eine Radiochemotherapie durchgeführt worden. Der klinische Status wurden 91 ± 52 Wochen nach der Ileostomieresektion mittels eines standardisierten Fragebogens erhoben und der Kontinenzgrad nach dem Wexner-Kontinenzscore bewertet. Der postoperative Kontinenzscore wurde mit den Befunden vor Stomarückverlagerung korreliert und ein Pearson-Korrelationskoeffizient berechnet. Ergebnisse: Es ergab sich eine signifikante Korrelation des Kontinenzgrades mit der Anastomosenhöhe (r = –0,58, p 〈 0,001), dem mittleren Ruhedruck (r = –0,52, p 〈 0,001) und der rectalen Compliance (r = –0,43, p = 0,001). Die Kontinenz war nach Radiochemotherapie schlechter (p = 0,0001). Es fand sich keine signifikante Korrelation zwischen Kontinenzgrad und funktioneller Sphincterlänge, Kneifdruck, Perceptionsschwelle, Drangschwelle, maximal tolerablem Volumen und Kontinenz für semiliquides Kontrastmittel. Schlußfolgerung: Inkontinenz nach Rectumresektion ist multifaktoriell. Anastomosenhöhe, mittlerer Ruhedruck, rectale Compliance und Radiochemotherapie (RCT) spielen eine dominante Rolle. Basierend auf diesen Befunden ist über die Berechnung einer multivariaten Regressionsanalyse eine Abschätzung des Kontinenzgrades vor Ileostomieresektion mit folgender Formel möglich: Prognose-Wexner-Score = 18,23–0,94 · Anastomosenhöhe – 0,18 · Ruhedruck + 3,72 · RCT.
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  • 15
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    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 357-364 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Orale Leukoplakie ; Mundhöhlenkarzinom ; Alkohol ; Tabak ; Prävention ; Prophylaxe ; Keywords ; Oral leukoplakia ; Oral cancer ; Alcohol ; Tobacco ; Prevention ; Prophylaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Epidemiologic data for the prevalence of oral cancer show marked geographic differences. The incidence of oral cancer in younger individuals seems to be on the increase. Prevalence of oral leukoplakia in German men is 2.3%, in women 0.9%. Risk factors for oral cancer and most variants of oral leukoplakia are identical. Etiologically, tobacco and alcohol are the most important factors. Tobacco in smoked, chewed or snuffed varieties has toxic, tumorigenic and carcinogenic properties. Consumption of tobacco has markedly increased during the last 15 years in some geographic areas. In Germany tobacco consumption has increased 7.5% during the last 4 years. Alcohol affects the permeability of oral mucosa. Oral cancer as well as most forms of oral leukoplakia are avoidable diseases. Strategies for prevention encompass primary, secondary and tertiary prevention. Primary prevention focuses on principal avoidance of tobacco. Anti-tobacco counselling and therapy is actively practised in dental practices in some countries. Intervention includes the 4 A’s as principles (ask, advise, assist, arrange) and is based on nicotine replacement therapy. General dental practice and hospital dentistry should introduce the principles of primary prevention of tobacco consumption. A questionnaire which was sent to EU countries indicated that dental teams are willing to introduce tobacco and alcohol counselling and relevant prevention strategies.
    Notes: Epidemiologische Daten für das Mundhöhlenkarzinom zeigen ausgeprägte geographische Unterschiede. Die Inzidenz des Mundhöhlenkarzinoms bei Jüngeren scheint zuzunehmen. Die Prävalenz der oralen Leukoplakie in Deutschland liegt für Männer bei 2,3%, für Frauen bei 0,9%. Die Risikofaktoren für das Mundhöhlenkarzinom und die meisten oralen Leukoplakien sind identisch. Tabak und Alkohol spielen die größte ätiologische Rolle. Tabak in gerauchter, gekauter oder geschnupfter Form hat toxische, tumorigene und karzinogene Eigenschaften. Der Tabakkonsum, insbesondere in Form von Zigaretten, hat in den letzten 15 Jahren in manchen geographischen Bereichen deutlich zugenommen. Der Zigarettenkonsum in Deutschland stieg in den letzten 4 Jahren um 7,5%. Alkohol und Tabak wirken synergistisch. Alkoholkonsum verändert die Permeabilität der Mukosa. Sowohl das Mundhöhlenkarzinom als auch die meisten oralen Leukoplakien sind vermeidbare Erkrankungen. Präventionsstrategien umfassen die Primär-, Sekundär- und Tertiärprävention. Die Primärprävention ist auf den grundsätzlichen Verzicht des Tabakkonsums gerichtet. Antitabakberatung und ¶-therapie werden in der zahnärztlichen Praxis in vielen Ländern bereits durchgeführt. Interventionsprinzipien umfassen Aufklärung und Antitabaktherapie, im Wesentlichen durch Nikotinersatztherapie. Die zahnärztliche Praxis sowie auch Kliniken sollten das Prinzip der Primärprophylaxe, also der Tabakvermeidung und Therapie, in ihr Behandlungsschema einbeziehen. Bisherige Umfragen im Rahmen der Europäischen Union haben gezeigt, dass das zahnärztliche Team grundsätzlich dazu bereit ist.
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  • 16
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Mikrovaskuläre Knochentransplantate ; Präformierte Fibulatransplantate ; ITI®-Implantate ; Defektrekonstruktion ; Keywords ; Microvasculary bone flaps ; Prefabricated fibula flaps ; ITI®-Implants ; Defect reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The reconstruction of extensive jaw defects is frequently only possible with microvascular bone flaps. Here we are presenting an operative technique using prefabricated fibular flaps and osseointegrated implants. In a first operation, the fibula is prepared with implants, split skin graft, and a nonresorbable membrane. The jaw defect is reconstructed 6 weeks later and can be treated directly with a prosthesis thanks to osseointegrated implants. The technique is described with reference to 5 patients already operated according to this technique and the initial findings are evaluated.
    Notes: Die Rekonstruktion von ausgedehnten Kieferdefekten ist häufig nur mit mikrovaskulären Knochentransplantaten möglich. Es wird hier eine Operationstechnik vorgestellt, bei der die Fibula präformiert wird. In der 1. Operation werden ITI-Implantate mit SLA-Oberfläche in die Fibula eingesetzt. Die Implantate und die Fibula werden mit Spalthaut und einer 1 mm dicken, nicht resorbierbaren Membran überdeckt. 6 Wochen nach der 1. Operation erfolgt in der 2. Operation die eigentliche Rekonstruktion des Kieferdefektes. Innerhalb dieser 6 Wochen sind die Implantate osseointegriert. Die Spalthaut, die wie bei einer Vestibulumplastik mit dem Periost verwachsen ist, bildet das stabile periimplantäre Weichgewebe. Die Implantate werden intraoperativ mit der vorbereiteten Suprastruktur verschraubt und gewähren durch die präoperativ bestimmte Okklusion die korrekte Positionierung des Transplantates. Postoperativ sind zudem die sofortige Funktion und Belastung möglich. Anhand von 5 Patienten werden diese Technik beschrieben und deren Resultate ausgewertet.
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  • 17
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    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 373-376 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Dysgnathiechirurgie ; Operationssimulation ; Weichgewebesimulation ; Computersimulation ; Keywords ; Orthognathic surgery ; Preoperative planning ; Soft tissue simulation ; Computer-aided simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background In addition to standard X-rays, photographic documentation, cephalometric and model analysis, a computer-aided, three-dimensional (3D) simulation system has been developed in close cooperation with the Institute of Communications of the Friedrich-Alexander-Universität Erlangen-Nürnberg. With this simulation system a photorealistic prediction of the expected soft tissue changes can be made. Prerequisites are a 3D reconstruction of the facial skeleton and a 3D laser scan of the face. After data reduction, the two data sets can be matched. Cutting planes enable the transposition of bony segments. The laser scan of the facial surface is combined with the underlying bone via a five-layered soft tissue model to convert bone movements on the soft tissue cover realistically. Conclusion Further research is necessary to replace the virtual subcutaneous soft tissue model by correct, topographic tissue anatomy.
    Notes: Hintergrund Im Rahmen eines Sonderforschungsbereichs der Deutschen Forschungsgemeinschaft (SFB 603) wurde in Zusammenarbeit mit dem Lehrstuhl für Nachrichtentechnik der Universität Erlangen-Nürnberg ein computergestütztes Simulationssystem zur dreidimensionalen, fotorealistischen Vorhersage von Weichgewebeveränderungen nach orthognathen Eingriffen entwickelt. Voraussetzung sind 3D-CT-Datensätze des Gesichtsschädels sowie eine ebenfalls dreidimensionale Laserabtastung der Gesichtsoberfläche. Beide Datensätze können nach Datenreduktion über ein mathematisches Verfahren so miteinander verknüpft werden, dass mit Hilfe so genannter “cutting planes” Verlagerungen von Knochensegmenten auf das bedeckende Weichgewebe realitätsnah übertragen werden können. Schlussfolgerung Es bedarf weiterer Forschungsanstrengungen, um auch die subkutanen Weichgewebelagen so in das Simulationsmodell zu integrieren, dass noch bestehende Abweichungen korrigiert werden können.
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  • 18
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    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 382-386 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Intraarterielle Chemotherapie ; Zytostatika ; Mundhöhlenkarzinom ; Tumorzellbiologie ; Keywords ; Intraarterial chemotherapy ; Cytostatic drugs ; Cancer oral cavity ; Tumor cell biology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background. The development of arterial chemotherapy in the course of the twentieth century is recapitulated, emphasizing the implications of advancements which have been made in anatomic examination and cell biology. Chemotherapy. The literature is reviewed to determine the current position of arterial chemotherapy among other treatment strategies. As a single modality treatment, it is exclusively employed as palliative treatment. Combined with surgery, radiation or immune therapy, arterial chemotherapy is of further significance as part of multimodality treatment. The best chance for cure is achieved if applied as induction therapy.
    Notes: Hintergrund. Die Arbeit gibt einen Überblick über die historische Entwicklung der arteriellen Chemotherapie im letzten Jahrhundert. Wichtige Entwicklungsschritte wie anatomische Untersuchungen und zellbiologische Erkenntnisse werden dargestellt. Chemotherapie. Anhand der Literatur über Ergebnisse der klinischen Behandlung wird der derzeitige Stellenwert der arteriellen Chemotherapie im Rahmen der onkologischen Therapiemodalitäten dargestellt. Es handelt sich um eine Behandlungsmethode, die im Sinn einer Monotherapie ausschließlich palliativ einzusetzen ist. Die Bedeutung der Methode liegt in der Kombination mit anderen Modalitäten wie Chirurgie, Strahlentherapie und Immuntherapie. Dabei ist die Methode am aussichtsreichsten, wenn sie als so genannte Induktionstherapie vorangestellt wird.
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  • 19
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    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 377-381 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Systemische Sklerodermie ; Parodontitis ; PECAM-1 ; Keywords ; Systemic sclerosis ; Periodontitis ; PECAM-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background. Systemic sclerosis (SSc) is a generalized disorder of the interstitial tissues and vasculature with distinct abnormalities in three systems, immune and autoimmune, vascular and microvascular, and mesenchymal extracellular matrix (ECM), that lead to exuberant fibrosis. The aim of this study was to compare the number of blood vessel profiles in the marginal gingiva between SSc patients and patients with periodontitis but without SSc by using biopsies. Methods. Marginal gingiva and gingival papilla were obtained from 13 scleroderma patients and 8 patients with periodontitis after routine tooth extraction and gingival curettage. On the histological sections, immunohistochemical investigations were performed using the avidin-biotin complex method (ABC) and the monoclonal antibody CD 31/Clone JC70A (platelet endothelial cell adhesion molecule-1). Blood vessels were identified by light microscopy (original magnification × 400) and counted within 0.3615 mm2. Medians of blood vessel profiles were compared by Mann-Whitney U-test. Results. There is no statistical difference between the median of blood vessel profiles in the marginal gingiva of SSc patients as compared to the median of blood vessel profiles in the marginal gingiva of patients with periodontitis (P = 0.665). We did not discover avascular areas in the subepithelial connective tissue. Discussion. The pathological changes in the microvasculature in the dermis of SSc patients are not transferable to the marginal periodont, as intraindividual histological examinations of dermis and oral mucosa in relation to the degree of the disease are not available yet.
    Notes: Hintergrund. Die systemische Sklerodermie ist eine relativ seltene, generalisierte Erkrankung des Bindegewebes. Im Krankheitsprozess spielen entzündliche und vaskuläre Phänomene eine wichtige Rolle. Methode. Anhand von Bioptaten der marginalen Gingiva wurde nach indizierten Zahnextraktionen oder Kürettagen der Vaskularisationsgrad im subepithelialen Bindegewebe der Gingiva von Sklerodermiepatienten mit demjenigen von Patienten mit einer Parodontitis verglichen. Die Mikrogefäßdichte (MVD) wurde immunhistochemisch mit Hilfe des monoklonalen Antikörpers CD31/Clone JC70A (platelet endothelial cell adhesion molecule-1, PECAM-1) dargestellt und lichtmikroskopisch quantitativ erfasst. Die statistische Auswertung der Mediane der Kapillaranschnitte erfolgte mit dem Mann-Whitney-U-Test. Ergebnisse. Die Mediane der Kapillaranschnitte bei den Sklerodermiepatienten (n = 13) und den Patienten mit Parodontitis (n = 8) erwiesen sich statistisch als nicht signifikant verschieden (p = 0,665). Im subepithelialen Bindegewebe der marginalen Gingiva wurden keine avaskulären Zonen gesehen. Diskussion. Die in der Dermis von Sklerodermiepatienten ablaufende Angiopathie ist nicht ohne weiteres auf das marginale Parodont übertragbar, da intraindividuelle histologische Untersuchungen von Dermis und Mundschleimhaut in Abhängigkeit vom Erkrankungsstadium derzeit nicht vorliegen. Das vorliegende Ergebnis rechtfertigt nicht, Probeexzisionen der Mundschleimhaut zu entnehmen, um das Krankheitsstadium einer Sklerodermie anzuzeigen oder eine prognostische Wertung vorzunehmen.
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  • 20
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    Mund-, Kiefer- und Gesichtschirurgie 4 (2000), S. 387-390 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter ; Schwannom ; Benigner Tumor ; Intraossäre Lokalisation ; Mandibula ; Unterkieferteilresektion ; Mikrochirurgische Nervenrekonstrukion ; Keywords ; Schwannoma ; Benign tumor ; Intraosseous localisation ; Mandible ; Partial resection of mandible ; Microsurgical reconstruction of nerve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Background: Schwannomas are rare benign neurogenic tumors that arise from Schwann cells of the peripheral nervous system. The most frequent localisation is the head and neck area. Extracranial schwannomas are most often located in the deep soft tissues. Intraosseous tumortypes are rare; the mandible is the most common site. Case report: We present the case of a 63-year-old woman with a schwannoma which originated from the mandible nerve and describe the therapy of this neoplasm. A rare malignant transformation cannot be excluded. Therefore, the treatment of choice is radical local resection.
    Notes: Hintergrund: Schwannome sind benigne Neubildungen, die ihren Ursprung von den Schwann-Zellen nehmen. Ihre Prädilektionsstelle ist die Kopf-Hals-Region. Sie treten zumeist im Verlauf des VIII. Hirnnervs auf. Extrakranial sind die Schwannome überwiegend ¶in den Weichgeweben lokalisiert. Eine intraossäre Lage ist selten, dann jedoch gewöhnlich in der Mandibula anzutreffen. Fallbericht: Eine 63-jährige Patientin wird vorgestellt, und die Therapie wird aufgezeigt. Die Behandlung sollte vergleichsweise radikal erfolgen, da trotz stabiler benigner Eigenschaften die Transformation in ein Malignom nicht definitiv ausgeschlossen werden kann.
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  • 21
    ISSN: 1432-0851
    Keywords: Key wordsαvβ3 ; Integrins ; Melanoma ; Blood vessels ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The αvβ3 integrin has emerged as a key mediator in angiogenesis. Its role in tumor-induced angiogenesis is supported by its up-regulation in vivo in the vasculature of a number of different types of carcinoma. The potential clinical significance of αvβ3 expression on blood vessels in carcinomas is suggested by its association with tumor progression. Currently no information is available about the clinical significance of αvβ3 expression on the vasculature of lesions of melanocytic origin. Since we have previously found that αvβ3 expression on melanoma cells in primary lesions is associated with a poor prognosis, in the present study we have compared αvβ3 expression on blood vessels and on cells of melanocytic origin in nevi and in malignant melanoma lesions. In addition we have examined the lesions for expression of the αv subunit to gain information on the regulation of αvβ3 expression on endothelial cells and on cells of the melanocyte lineage. αvβ3 expression on endothelial cells and on melanocytic cells was a relatively sensitive and specific marker for malignant lesions. However, αvβ3 expression on endothelial cells in primary melanoma lesions was not associated with the prognosis of the disease. The αv subunit and the αvβ3 complex were differentially expressed on endothelial cells and on melanocytic cells, implying that different regulatory pathways control their expression. This finding may account for the differential clinical significance of αvβ3 expression on tumor vasculature and on melanoma cells we observed in our patient cohort. Lastly, αvβ3 may be a useful target for immunotherapeutic approaches in melanoma because of its high expression on the vasculature of all metastatic lesions tested and its restricted distribution in normal tissues.
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  • 22
    ISSN: 1432-0851
    Keywords: Key words IL-2 serum levels ; NSCLC ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Interleukin(IL)-2 is a T helper (Th) 1 type cytokine that has been shown to play an important role in antitumour immune responses. In this study, the prognostic significance of serum IL-2 levels was investigated in 60 advanced non-small-cell lung cancer (NSCLC) patients. IL-2 serum levels were determined before chemotherapy, at the end of chemotherapy and during follow-up, using a commercially available enzyme-linked immunoadsorbent assay kit. The results were analysed according to the response to therapy and were used to generate a model predicting overall survival and time to treatment failure. All 60 patients were shown to have higher IL-2 serum levels than controls (P 〈 0.0001). Stage IV patients had significantly lower IL-2 levels than stage III patients (P 〈 0.0001), although they were still significantly higher than controls (P 〈 0.0001). It is interesting that, when patients were divided into responders and non-responders according to the response to therapy, the former were shown to have significantly higher pre-chemotherapy levels than the latter (P 〈 0.0001). Moreover, a further significant increase in IL-2 serum levels (P=0.004) and a significant decrease (P 〈 0.0001) were shown in responders and non-responders, respectively at the end of the therapy. Using univariate and multivariate analyses, both overall survival and time to treatment failure were shown to be affected by the mean pathological levels of IL-2. Furthermore, the prognostic significance of the serum level of IL-2 was confirmed by the stepwise regression analysis. In conclusion, determination of pre-treatment IL-2 serum levels was shown to be of independent prognostic utility in patients with advanced NSCLC; therefore, its possible use for prediction of outcome is proposed.
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  • 23
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    European journal of orthopaedic surgery & traumatology 10 (2000), S. 199-202 
    ISSN: 1432-1068
    Keywords: Abscess ; Prognosis ; Spinal epidural abscess
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five patients suffering from spinal epidural abscess associated with neurologic deficit are reported. Four patients underwent a decompressive procedure for abscess drainage, and one patient was medically treated. One of the patients showed a neurologic deterioration at the early postoperative period. The long-term follow-up showed a good outcome in all patients. It is concluded that epidural abscess associated with progressive neurologic deficit requires immediate decompression and administration of antibiotic. Postoperative neurological deterioration may be seen despite proper and immediate decompression and in such a case neurologic improvement is observed in the late postoperative period.
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  • 24
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    Archives of gynecology and obstetrics 264 (2000), S. 13-19 
    ISSN: 1432-0711
    Keywords: Key words Fallopian tube cancer ; Radiotherapy ; Chemotherapy ; Lymph node metastasis ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective: To contribute toward the understanding of the therapeutic management of fallopian tube cancer. Methods: Recent studies related to the treatment of fallopian tube cancer were reviewed. Results: Current evidence indicates that even patients in early stages have nodal disease, and often experience relapses in distant sites. In advanced stages, survival prolongation by the use of platinum-based chemotherapy has been demonstrated. Aggressive cytoreductive surgery followed by chemotherapy and negative second-look laparotomy offer the possibility of long-term survival. However, a significant fraction of patients eventually relapses after negative second-look laparotomy, and a poor survival rate after positive second-look laparotomy has been observed. Conclusions: This series suggests the need for thorough evaluation of lymph nodes at the time of surgery. The use of platinum-based chemotherapy is probably the best adjuvant therapy for both early stages and advanced stages. The clinical value of second-look laparotomy will remain limited until effective salvage therapy is developed. The potential benefits of neoadjuvant chemotherapy and the use of paclitaxel will be increasingly important.
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  • 25
    ISSN: 1432-1238
    Keywords: Key words Acute renal failure ; 80 years old ; Etiology ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To determine the epidemiological trends, spectrum of etiologies, morbidity and mortality of acute renal failure (ARF) in patients over 80 years old.¶Design: Historical cohort analysis.¶Setting: Intensive care unit (ICU) of nephrology, Tenon Hospital, Paris.¶Patients and participants: The criteria of inclusion was ARF, defined on the basis of a creatinine value over 120 μmol/l, in patients over 80 years of age admitted between October 1971 and September 1996. When moderate chronic nephropathy was pre-existing, ARF was defined by the increase of at least 50 % over the basal creatininemia.¶Measurements and results: Three hundred and eighty-one patients over 80 years of age were included. The etiology and mechanism of ARF are detailed. 29 % of the patients received dialysis. Global mortality at the hospital was 40 %. Factors significantly associated with a poor prognosis are identified. Mean survival after hospitalization was 19 months.¶Conclusion: The frequency of admission to ICUs for ARF in patients older than 80 years seems to be on the increase. Mortality is less severe than expected. These patients could benefit from the renal replacement therapy of modern intensive care medicine.
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  • 26
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 26 (2000), S. S064 
    ISSN: 1432-1238
    Keywords: Key words Bacteraemia ; Sepsis ; Septic shock ; Epidemiology ; Prognosis ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the incidence, risk factors, aetiologies and outcome of the various forms of the septic syndromes (the systemic inflammatory response syndrome [SIRS] sepsis, severe sepsis, and septic shock) and their relationships with infection.¶Design: Review of published cohort studies examining the epidemiology of the septic syndromes, with emphasis on intensive care unit (ICU) patients.¶Results: The prevalence of SIRS is very high, affecting one-third of all in-hospital patients, and 〉 50 % of all ICU patients; in surgical ICU patients, SIRS occurs in 〉 80 % patients. Trauma patients are at particularly high risk of SIRS, and most these patients do not have infection documented. The prevalence of infection and bacteraemia increases with the number of SIRS criteria met, and with increasing severity of the septic syndromes. About one-third of patients with SIRS have or evolve to sepsis. Sepsis may occur in approximately 25 % of ICU patients, and bacteraemic sepsis in 10 %. In such patients, sepsis evolves to severe sepsis in 〉 50 % of cases, whereas evolution to severe sepsis in non-ICU patients is about 25 %. Severe sepsis and septic shock occur in 2 %–3 % of ward patients and 10 %–15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. There is a graded severity from SIRS to sepsis, severe sepsis and septic shock, with an associated 28-d mortality of approximately 10 %, 20 %, 20 %–40 %, and 40 %–60 %, respectively. Mortality rates are similar within each stage, whether infection is documented or not, and microbiological characteristics of infection do not substantially influence outcome, although the source of infection does. While about three of four deaths occur during the first months after sepsis, the septic syndromes significantly impact on long-term outcome, with an estimated 50 % reduction of life expectancy over the following five years. The major determinants of outcome, both short-term and long-term, of patients with sepsis are the severity of underlying diseases and comorbidities, the presence of shock and organ failures at onset of sepsis or evolving thereafter. It has been estimated that two-thirds of the overall mortality can be attributed to sepsis.¶Conclusions: The prevalence of sepsis in ICU patients is very high, and most patients have clinically or microbiologically documented infection, except in specific subset of patients. The prognosis of septic syndromes is related to underlying diseases and the severity of the inflammatory response and its sequelae, reflected in shock and organ dysfunction/failures.
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  • 27
    ISSN: 1432-1084
    Keywords: Key words: MR imaging ; Non-small cell lung cancer ; Therapeutic effect ; Prognosis ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to evaluate the therapeutic effect more accurately and predict the prognosis of treated non-small cell lung cancer by using contrast-enhanced magnetic resonance imaging (CE-MRI). Contrast-enhanced computed tomography (CE-CT) and CE-MRI were examined 90 non-small cell lung cancer patients treated with conservative therapies. Enhancement patterns of CE-MRI were classified into three types: peripheral; mottled; and homogeneous. Reduction ratio of tumor size (RRT) based on the World Health Organization response criteria and a new response rate; reduction ratio of viable tumor size (RRVT) which evaluates not only the reduction of tumor size but also changes in necrosis and/or cavity size, were evaluated. Changes of enhancement pattern were compared and correlated with pathological diagnosis. The RRTs, RRVTs, and interobserver agreements evaluated by all modalities were compared. The RRTs and RRVTs in each subgroup were correlated and compared with prognoses. Change of enhancement pattern depended on therapy had no tendency (p = 0.06). Enhancement pattern had significant correlation with pathological diagnosis (p 〈 0.0001). Partial response (PR) case of RRVT had significant difference between imaging techniques (p = 0.04). The RRVT of other cases and RRT had no significant difference. Interobserver agreements of RRT and RRVT were almost perfect (ϰ≥ 0.93). Prognosis had better correlation with RRVT than with RRT. Differences of relapse-free survival and survival between patients considered as having no change (NC) by RRT and PR by RRVT (NC-PR) and patients considered as having NC by RRT and RRVT were significant (p = 0.03, p = 0.01). There were no significant differences of relapse-free survival and survival between NC-PR patients and patients considered as having PR by RRT and RRVT. The CE-MRI technique could accurately evaluate the therapeutic effect and predict the prognosis of treated non-small cell lung cancer.
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  • 28
    ISSN: 1279-8509
    Keywords: Acute myeloid leukemia ; Chemotherapy ; Allogenic transplantation ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to assess the place of HLA-identical allogeneic bone marrow transplantation (BMT) and to compare it to other post-induction therapies, we analyzed patient outcome in intention-to-treat based on the presence or not of an HLA-identical familial donor in young adults with de novo acute myeloid leukemia (AML) in first complete remission (CR). Between 1985 and 1998, 152 consecutive AML patients aged less than 41 years old, seen in our institution, were treated according to 3 different successive protocols (LYLAM85, LAM90, AML10). 144/152 patients entered our prospective study in which they were registered at time of diagnosis for presence or absence of HLA-identical donor and analyzed in intention-to-treat. In this study, 52 patients (36%), who had at least one identical sibling donor (group 1), were offered allogeneic BMT after CR achievement. The 92 patients without donor were allocated to group 2 and were assigned to receive chemotherapy or autologous transplantation as post-remission according to the protocol they were initially included in. Patients from both groups had similar disease characteristics at diagnosis. Karyotypes at diagnosis were defined as low risk (t(8;21) or t(15;17) or chromosome 16 abnormalities(, intermediate risk (normal karyotypes), or high risk (other abnormalities). Overall, 114/152 patients (75%) achieved a CR. Of the 144 eligible patients, 46/52 (88%) with a donor and 68/92 (74%) without a donor achieved a CR. The median follow-up duration of the 144 patients was 21.2 months. The relapse rate was higher in group 2 (56%) than in group 1 (31%). However, the overall survival was not different between patients with and without donor (median survival respectively at 16.7 months and 26.6 months with estimated survival at 5 years respectively at 32% and 34%). Thirty-four patients from group 1 (65%) were actually transplanted in first CR. The probability of 5-year survival for patients receiving effectively allogeneic BMT was 44% and was not significantly better than that of patients who did not. In univariate as in multivariate analysis, karyotypic status was the main prognostic factor for CR achievement (p = 0.002), CR duration (p 〈 0.0001), and overall survival (p 〈 0.0001). There were no significant differences between group 1 and group 2 when survivals were compared with adjustment for karyotypes. We conclude that the availability of an HLA-identical sibling donor did not confer any prognostic advantage in terms of outcome for young adults with AML in first CR. These results make allogeneic BMT process questionable as systemic post-remission therapy in patients with an HLA-identical familial donor.
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  • 29
    ISSN: 1279-8517
    Keywords: Gastric carcinomas ; Cardiac carcinomas ; TNM-classification ; Prognosis ; Lesser and greater omenta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The problem of T classification of proximal gastric carcinomas is becoming increasingly important due to a rise in the incidence of these tumors. The aim of this study was to examine the gastric insertion of the lesser and greater omenta and its role in the T classification of gastric carcinomas. The stomach and greater and lesser omenta were removed from 76 fixed cadavers and 12 measurements each were done in defined localizations. The lesser omentum extended to the gastric wall in 98% of the cases. This junction as well as the omental thickness and thus the retroperitoneal part are especially pronounced in the cardiac region. According to the current UICC classification, even advanced tumors extending into the gastric wall can be classified T2 as long as they do not penetrate the visceral peritoneum. This results in « understaging » and a seemingly poorer prognosis for cardiac carcinomas. Our study results support the recommendation of Hermanek and Wittekind [5] to subdivide the T2 stage of gastric carcinomas on the basis of infiltration depth.
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  • 30
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    Springer
    Annals of hematology 79 (2000), S. 455-458 
    ISSN: 1432-0584
    Keywords: Key words Anterior chamber ; Hypopyon ; Leukemia ; Extramedullary ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We encountered a patient with acute myelogenous leukemia (AML) who developed leukemic hypopyon. Leukemia initially spread into the pharynx, gingiva, lymphnode, and bone marrow. He achieved complete remission after chemotherapy but developed blurred vision and hypopyon. Anterior chamber paracentesis disclosed leukemic infiltration of the anterior chamber. Infiltration of the central nervous system also occurred. He received systemic chemotherapy, intrathecal chemotherapy, and local chemotherapy. However, he did not achieve prolonged remission. These findings suggest that these chemotherapy treatments have an inadequate effect for AML with anterior chamber infiltration. This rare complication is associated with extramedullary infiltration of leukemia.
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  • 31
    ISSN: 1248-9204
    Keywords: Hernia ; Strangulation ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is believed that direct hernias are less likely to strangulate because, in contrast to an indirect inguinal hernia, the neck of the direct hernia is wide. For this reason, some surgeons do not repair direct hernias in I elderly patients. We analyzed all incarcerated hernias repaired on an emergency basis during a 3-year period in order to discover the extent of incarcerated direct hernias in our practice. A total of 293 patients with incarcerated hernia were evaluated; of these, 222 were inguinal (193 indirect −86.9%- and 29 direct −13.1%-). The strangulation rate for inguinal hernias was found to be 29.7%. There was a significant difference between indirect and direct inguinal hernias in respect to strangulation rate (32.6% vs 10.3% p = 0.014). However, we did not find any difference between bowel resection rates in incarcerated-strangulated indirect and direct hernias (14/193 −7.3%- vs 2/29 −6.9%-, p = 0.95). Hospitalization time was significantly longer for the patients who developed strangulation than those who did not. The side of direct hernia had no effect on strangulation (10.5% for right-sided vs 10.0% for left-sided, p = 0.97). The only prognostic factor for strangulation and resection in regression analysis was the age-group of the patients (〈 60 vs. 60 or older). At operation the average diameter of the defect in the transversalis fascia was 23.8 mm. The diameter of the defect had no effect on strangulation.
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  • 32
    ISSN: 1534-4681
    Keywords: Rectal cancer ; Intensive follow-up ; Local recurrence ; Reoperation ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Because more than 90% of local recurrences after curative surgery for rectal cancer appear within the first 36 months after surgery, an intensive and strict follow-up program during this period could improve early diagnosis and, thus, prognosis of patients. Methods: Of the 216 patients who underwent surgery for rectal cancer, 127 entered an intensive follow-up program (median follow-up: 42 months); the clinical outcome of the remaining 89 patients was reconstructed with the help of their general practitioners. Results: Fifty eight (26.8%) of the 216 patients who were treated with curative surgery alone developed a local recurrence; pelvic recurrences were prevalent. Eleven (30.5%) of the 36 patients who had recurrence during follow-up, and 6 of the 22 who had not undergone follow-up, had a reoperation with curative intent; the median survival was 19 months vs. 8 months, respectively (P 5 ns). Four (44.4%) curative reoperations were performed on the 9 asymptomatic patients and in 13 (26.5%) of the 49 cases with symptomatic local recurrences. Median survival was 15 months vs. 14 months, respectively (P 5 n.s). All patients except one (living after 42 months from reoperation) died within 48 months. Conclusions: In our study, adherence to a strict follow-up program unfortunately proved to be ineffective for improving long-term survival for patients who underwent reoperation with curative intent.
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  • 33
    ISSN: 1534-4681
    Keywords: Gastric cancer ; Prognosis ; Pepsinogen C ; Pepsinogen A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In this study we evaluated the expression and clinical significance of pepsinogen C, an aspartic proteinase involved in the digestion of proteins in the stomach, in patients with gastric cancer. Methods: Pepsinogen C expression was examined by immunohistochemical methods in a series of 95 gastric carcinomas. The prognostic value of pepsinogen C was retrospectively evaluated by multivariate analysis taking into account conventional prognostic parameters. Follow-up period of patients was 21.4 months. Results: A total of 25 (26.3%) gastric carcinomas stained positively for pepsinogen C. The percentage of pepsinogen C-positive tumors was higher in well-differentiated (50%) than in moderately differentiated (19.5%) and poorly differentiated (21.9%) tumors (P 〈 .05). Similarly, significant differences in pepsinogen C immunostaining were found between node-negative and node-positive tumors (47.1% vs. 14.7%; P 〈 .001). In addition, statistical analysis revealed that pepsinogen C expression was associated with clinical outcome in gastric cancer patients. Low pepsinogen C levels predicted short overall survival periods in the overall group of patients with gastric cancer (P 〈 .001), and in 71 patients with resectable carcinomas (P 〈 .005). Multivariate analysis according to Cox’s model indicated that pepsinogen C immunostaining was an independent predictor of outcome for both overall and resectable gastric cancer patients (P 〈 .05, for both). Conclusions: The expression of pepsinogen C in gastric cancer may represent a useful biological marker able to identify subgroups of patients with different clinical outcomes.
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  • 34
    ISSN: 1534-4681
    Keywords: Stomach ; Cancer ; Gastric cancer ; Lymph node metastasis ; Prognosis ; Survival rate ; Multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: In gastric cancer, the level and number of lymph node metastases is useful for predicting survival, and there are several staging systems for lymph node metastasis. The aim of this study was to compare the several lymph node classifications and to clarify the most important lymph node information associated with prognosis using multivariate analysis. Methods: A total of 106 patients with histologically node-positive gastric cancer treated by radical gastrectomy and extended lymph node dissection (D2, D3) were studied. The level of lymph node metastasis was categorized simply as Level I nodes (perigastric, No.1–6), Level II nodes (intermediate, No.7–9), and Level III nodes (distant, No.10–16), irrespective of the tumor location. The Level II nodes included lymph nodes along the left gastric artery, common hepatic artery, and celiac trunk. Results: Overall 5-year survival rate was 51%. Univariate analysis showed that 5-year survival rate was significantly influenced by the level of positive nodes (P 〈 .01), total number of positive nodes (P 〈 .01), number of positive Level I nodes (P 〈 .01), and number of positive Level II nodes (P 〈 .01), in addition to the tumor location (P 〈 .05), tumor size (P 〈 .05), gross type (P 〈 .01), and depth of wall invasion (P 〈 .01). Of these, independent prognostic factors associated with 5-year survival rate were the number of positive Level II nodes (0–1 vs. ≥2) (62% vs. 19%, P 〈 .01) and the depth of wall invasion (within vs. beyond muscularis) (79% vs. 43%, P 〈 .01). Conclusions: Among several staging systems for lymph node metastases, the number of positive Level II nodes provided the most powerful prognostic information in patients with node-positive gastric cancer. When there were two or more metastases in the Level II nodes, prognosis was poor even after D2 or D3 gastrectomy.
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  • 35
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    Strahlentherapie und Onkologie 176 (2000), S. 513-516 
    ISSN: 1439-099X
    Keywords: Key Words: Breast cancer ; Zoster ; Radiotherapy ; Prognosis ; Schlüsselwörter: Mammakarzinom ; Zoster ; Radiotherapie ; Prognose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Hintergrund: Wir haben in einer retrospektiven Analyse die Häufigkeit eines Herpes zoster bei Patientinnen mit Mammakarzinom und postoperativer Radiotherapie untersucht. Patientinnen und Methode: Von Januar 1985 bis Dezember 1993 erhielten 1 155 Patientinnen an unserer Klinik eine postoperative Bestrahlung nach Mastektomie (n = 961) oder brusterhaltende Operation (n = 194) in kurativer Intention. Das Alter betrug 34 bis 79 Jahre. 443 (38%) waren prä- und 712 (62%) postmenopausal, 21% hatten T3- bis T4-Tumoren, und 55% wiesen einen axillären Lymphknotenbefall auf. Alle Patientinnen erhielten eine Bestrahlung der Restbrust bzw. Thoraxwand bis 50 Gy, bei mastektomierten Patientinnen wurden zusätzlich die regionären Lymphknoten mit 44 Gy bestrahlt. 65% der Patientinnen erhielten eine zusätzliche Systemtherapie. Die Nachbeobachtungszeit betrug drei Monate bis 12,5 Jahre (Median 3,1 Jahre). Ergebnisse: 41/1 155 Patientinnen (3,7%) entwickelten im Nachbeobachtungszeitraum einen Herpes zoster. Alle Infektionen waren lokalisiert, eine generalisierte Hautinfektion oder systemische Infektionen traten nicht auf. Alter, Menopausenstatus, Erkrankungsstadium oder Art der Therapie (Brusterhaltung vs. Mastektomie, zusätzliche Chemotherapie) hatten keinen Einfluss auf die Frequenz von Zoster. Patientinnen mit starker akuter Hautreaktion waren ebenfalls nicht signifikant stärker betroffen als Patientinnen mit geringer Hautreaktion im Bestrahlungsfeld (5% vs. 2%). Das Auftreten eines Zosters nach Therapie hatte keinen Einfluss auf die Prognose hinsichtlich lokaler Kontrolle oder Überleben. Schlussfolgerungen: Die beobachtete Häufigkeit von Herpes zoster (etwa 4% nach drei Jahren Follow-up) lässt vermuten, dass ein Herpes zoster im untersuchten Kollektiv etwa drei- bis fünffach häufiger auftritt als anhand der Inzidenzen in der Normalbevölkerung erwartet. Dies ist nicht mit einer schlechteren Prognose assoziiert. Ob die erhöhte Frequenz auf die Radiotherapie zurückzuführen ist oder in Zusammenhang mit der Krebserkrankung steht, kann nich beurteilt werden.
    Notes: Background: We have studied the incidence of herpes zoster in patients with adjuvant radiotherapy for breast cancer with special emphasis on possible correlations with other prognostic factors or survival. Patients and Methods: From 1/1985 through 12/1993, 1 155 breast cancer patients received postoperative radiotherapy with curative interent in our department. After mastectomy 961 patients were irradiated and after breast-preserving treatment 194 patients. The age ranged from 34 to 79 years, the median follow-up was 3.1 years (range: 0.3 to 12.4 years). There were 443 women (38%) pre- and 712 (62%) postmenopausal. 21% had T3- to T4-tumors, 55% had axillary lymph node involvement, and 65% received additional systemic hormonal and/or cytotoxic therapy. In case of postmastectomy radiotherapy, the lateral chest wall and lymphatics (axilla, parasternal and supraclavicular nodes) were irradiated with an anterior photon field to 50 Gy (axilla 44 Gy) and most of the chest wall with an electron field to 44 Gy in 2-Gy fractions. After breast-preservation, the breast was irradiated via tangential fields with 6- to 8-MV photons up to 50 Gy plus 8 Gy electron boost to the tumor bed. Most of the patients were followed routinely in the department for 2 to 5 years. The frequency of zoster was determined retrospectively by reviewing the patients' records. Results: A zoster after radiotherapy occurred in 41/1 155 patients (3.7%), mostly within the first 2 years after completion of radiotherapy. All infections remained localized and there was no evidence for systemic infections. Type of treatment (mastectomy vs breast-preservation) had no impact on the frequency of herpes zoster (36/961 patients after mastectomy and 5/194 patients after breast-preservation). There was also no correlation with other prognostic factors such as age, menopausal status, stage of disease or the use of adjuvant chemotherapy, nor was the occurrence of zoster linked to the degree of acute skin reaction in the radiation field. Moreover, patients with zoster had the same prognosis as compared to patients without zoster with regard to local control and survival. Conclusions: The observed frequency of zoster (about 4% of patients after postoperative radiotherapy) in this retrospective study suggests that the risk of developing zoster in this patient group may be 3- to 5-fold higher as compared to the incidence in the general population. However, the occurrence of zoster was not linked to prognosis and treatment response.
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  • 36
    ISSN: 1436-3305
    Keywords: Key words Hypergastrinemia ; Carcinoid tumor ; Prognosis ; Autoimmune gastritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Gastric carcinoid tumors associated with chronic atrophic gastritis type A have been reported to show good prognosis, because invasion and metastasis are rare. We report a case of gastric carcinoid tumor associated with hypergastrinemia that showed no malignant changes for 12 years. A 15-year-old man with abdominal discomfort underwent endoscopic examination. A polypoid lesion was detected on the atrophic mucosa of the fundus, and was diagnosed as a carcinoid tumor. Serological examination revealed a high level of anti-parietal-cell antibody, suggesting that the patient had chronic atrophic gastritis type A. The tumor was treated by endoscopic mucosal resection. Follow-up examinations were performed for 12 years, but showed no recurrence. This case confirms that gastric carcinoid tumors associated with chronic atrophic gastritis type A may have a good prognosis.
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  • 37
    ISSN: 1436-3305
    Keywords: Key words Stomach ; Cancer ; Gastric cancer ; Lymph node metastasis ; Prognosis ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. Although many authors have investigated the prognostic factors of gastric cancer, there are few comprehensive studies on the prognosis of patients with extensive lymph node metastasis. The aim of this study was to clarify the prognostic factors of gastric cancer with extragastric lymph node metastasis, using multivariate analysis. Methods. The study population consisted of 121 patients who had undergone radical gastrectomy and extended lymph node dissection (D2, D3) for gastric cancer with extragastric lymph node metastasis. We examined 18 clinicopathologic factors, including the type of gastrectomy, tumor size, depth of wall invasion, status of lymph node metastasis, and stage of disease. Survival rates were analyzed by the Kaplan-Meier and Mantel-Cox methods, and multivariate analysis was done using the Cox proportional hazards model. Results. The overall 5-year survival rate was 32%, and the 5-year survival rate after curative gastrectomy was 37%. Overall survival rate was associated with the type of gastrectomy, stage of disease, operative curability, tumor size, depth of wall invasion, and anatomical distribution of positive nodes, whereas the survival rate after curative gastrectomy was correlated with the type of gastrectomy, stage of disease, tumor size, gross type, and depth of wall invasion. Independent prognostic factors were operative curability and depth of wall invasion, and survival after curative gastrectomy was influenced only by the depth of wall invasion (mucosa and submucosa [T1], muscularis and subserosa [T2] vs serosa [T3]). Conclusion. In patients with gastric cancer with extragastric lymph node metastasis, independent prognostic factors after gastrectomy were operative curability and depth of wall invasion. Long-term survival can be achieved when the patients have no serosal invasion (T1, T2) and are treated by curative gastrectomy.
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  • 38
    ISSN: 1530-0358
    Keywords: Microscopic peritoneal dissemination ; Colon-cancer ; Gastric cancer ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: We evaluated the incidence and prognostic relevance of microscopic intraperitoneal tumor cell dissemination of colon cancer in comparison with dissemination of gastric cancer as a rational for additive intraperitoneal therapy. METHODS: Peritoneal washouts of 90 patients with colon and 111 patients with gastric cancer were investigated prospectively. Sixty patients with benign diseases and 8 patients with histologically proven gross visible peritoneal carcinomatosis served as controls. Intraoperatively, 100 ml of warm NaCl 0.9 percent were instilled and 20 ml were reaspirated. In all patients hematoxylin and eosin staining (conventional cytology) was performed. Additionally, in 36 patients with colon cancer and 47 patients with gastric cancer, immunostaining with the HEA-125 antibody (immunocytology) was prepared. The results of cytology were assessed for an association with TNM category and cancer grade, based on all patients, and with patient survival, among the R0 resected patients. RESULTS: In conventional cytology 35.5 percent (32/90) of patients with colon cancer and 42.3 percent (47/111) of patients with gastric cancer had a positive cytology. In immunocytology 47.2 percent (17/36) of patients with colon cancer and 46.8 percent (22/47) of patients with gastric cancer were positive. In colon cancer, positive conventional cytology was associated with pT and M category (P=0.044 andP=0.0002), whereas immunocytology was only associated with M category (P=0.007). No association was found between nodal status and immunocytology in colon cancer and with the grading. There was a statistically significant correlation between pT M category and conventional and immunocytology in gastric cancer (P〈0.0015/P=0.007 andP〈0.001/P=0.009, respectively). Positive immunocytology was additionally associated with pN category (P=0.05). In a univariate analysis of R0 resected patients (no residual tumor), positive immunocytology was significantly related to an unfavorable prognosis in patients with gastric cancer only (n=30). Mean survival time was significantly increased in patients with gastric cancer with negative cytology compared with positive cytology (1,205 (standard error of the mean, 91)vs. 771 (standard error of the mean, 147) days;P=0.007) but not in patients with colon cancer (1,215 (standard error of the mean, 95)vs. 1,346 (standard error of the mean, 106) days;P=0.55). CONCLUSIONS: Because microscopic peritoneal dissemination influences survival time after R0 resections only in patients with gastric but not with colon cancer, our results may provide a basis for a decision on additive, prophylactic (intraperitoneal) therapy in gastric but not colon cancer.
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  • 39
    ISSN: 1530-0358
    Keywords: Abdominoperineal resection ; Laparoscopy ; Colorectal carcinoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Although laparoscopic colorectal surgery is attracting ever more attention, its use for curative treatment of colorectal carcinoma in particular continues to be controversial. The present study was an attempt to analyze the results of the perioperative course, oncologic quality, and preliminary long-term results. METHOD: The data considered here were collected within the framework of a prospective, observational study initiated on August 1, 1995, and involving a total of 18 institutions in Germany and Austria. At the end of three years, the results are now being presented selectively,i.e., focusing only on abdominoperineal resection. RESULTS: A total of 116 patients underwent laparoscopic abdominoperineal resections, 98 (84.5 percent) of which were performed with curative intent. The mean operating time was 226 (confidence interval, 140–365) minutes. Seven patients (6 percent) experienced an intraoperative complication, which in more than one-half of the cases was a vascular injury involving the presacral venous plexus; the conversion rate was 3.4 percent. Postoperatively, 40 patients developed 97 complications—including those of a very minor nature—giving an overall morbidity rate of 34.4 percent. Reoperation in six patients (5.2 percent) had to be performed for an afterbleed in one-half of the cases and ileus in the other one-half. Postoperative mortality was a low 1.7 percent. In most of the curative resections, an oncologically radical operation with high transection of the inferior mesenteric artery and a complete dissection of the pelvis down to the floor was performed. The median number of lymph nodes investigated was 11.5, and there was wide fluctuation in the numbers among the individual institutions. Tumor cell dissemination occurred intraoperatively in five patients. In the meantime, 79 patients (81 percent) underwent at least one follow-up examination, the mean follow-up period being 491 days. Seven patients developed a local recurrence, and a further six patients developed distant metastases. For recurrence-free survival rate, the Kaplan-Meier estimation calculated a probability of 71 percent. CONCLUSION: Not all of the reservations about laparoscopic abdominoperineal resection, in particular with regard to resection with curative intent, have yet been eliminated. The present study does, however, show that a laparoscopic approach can in principle meet oncologic requirements of radicality and, with regard to the postoperative course, is associated with considerable benefits to the patient.
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  • 40
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    Diseases of the colon & rectum 43 (2000), S. 1222-1226 
    ISSN: 1530-0358
    Keywords: Colorectal neoplasms ; Young age ; Case-control study ; Pathology ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Colorectal adenocarcinoma before the age of 40 is uncommon, and its prognosis is controversial, with many studies reporting a worse prognosis than in older patients and others showing no difference. The current study compared two groups of patients who had surgical resection for colorectal adenocarcinoma. METHODS: The case group was composed of 34 patients younger than 40 (34 ± 4) years. Detailed pathologic prognosis factors, tumor cell proliferation measured by proliferating cell nuclear antigen, survival, family history, and predisposing conditions were analyzed. Results were compared with a control group constituted of 34 patients older than 65 (75 ± 6) years matched by gender, cancer site, and Dukes stage. RESULTS: Tumor differentiation, presence of vascular and perineural neoplastic invasion, tumor growth pattern, tumor cell proliferation measured by proliferating cell nuclear antigen count, and survival according to the Kaplan-Meier method were not significantly different between younger and older patients. The only difference between the two groups was a higher prevalence of family history and predisposing conditions for colorectal cancer in younger patients (23vs. 3 percent;P=0.03). CONCLUSION: This case-control study documents that pathologic features and prognosis of colorectal adenocarcinoma are comparable in patients younger than 40 years compared with older patients for identical stages. The higher prevalence of positive family history in younger patients suggests a different genetic background compared with older patients.
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  • 41
    ISSN: 1534-4681
    Keywords: Gastric cancer ; Younger patients ; Elderly patients ; Comparative study ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Gastric cancer is one of the most common gastrointestinal malignancies worldwide. Some studies have suggested that it has a worse prognosis in young than in elderly patients. Methods: All young and elderly patients treated for gastric adenocarcinoma during the period 1988 to 1994 in a tertiary referral center in Mexico City were included. Demographic, clinical, and pathologic features of young patients (less than 40 years of age) with gastric cancer were compared with those of elderly patients (70 years of age or older) with the same diagnosis. Overall survival was the main outcome measure. Results: There were 38 patients in each group. The mean age of the young and elderly groups was 33 and 77 years, respectively. Family history of gastric cancer was reported by 6 patients of the younger group and by 1 patient in the older group (P 〈 .05). Most patients in both groups were symptomatic and had an advanced stage of the disease. With a mean follow-up of 17 months, the overall median survival for all patients was 12 months. By group, the median survival was 13 and 12 months for the young and elderly patients, respectively (P = .38). Variables with significant impact on survival were the stage of the disease, possibility of surgical resection, location of the tumor, and a family history of gastric cancer. Conclusions: Young patients represent a significant proportion of patients with gastric cancer in Hispanic populations. There were no significant differences in clinicopathological characteristics and outcome of gastric adenocarcinoma between young and elderly patients. Survival was determined by the stage of the tumor and the possibility of complete surgical resection.
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  • 42
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    Annals of surgical oncology 7 (2000), S. 520-525 
    ISSN: 1534-4681
    Keywords: Proximal gastric third ; Adenocarcinoma ; Total gastrectomy ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The incidence of proximal gastric third carcinoma (PGC) has been rising in recent years. Classification and surgical therapy remain controversial. Methods: Between May 1986 and October 1997, 532 patients were operated for primary gastric carcinoma. All patient data were analyzed retrospectively comparing findings in patients with PGC and those with distal gastric carcinoma (DGC). Results: Two hundred fifty patients had a PGC, and 282 patients had a DGC. The rate of R0 resections was 79.3% for PGC and 81.6% for DGC. In 93.9% of the patients with PGC total gastrectomy was performed; for DGC total gastrectomy was done in 74.5% of patients. Postoperative morbidity and mortality were 29.2% for PGC and 23.8% for DGC, and 3.2% for PGC and 3.5% for DGC, respectively. Patients with advanced tumor stages (stage III and IV) were more common in the PGC group (73.3% vs. 53.6% in DGC). After R0 resection, the 5-year survival rate was 33.2% for PGC and 59.7% for DGC. Conclusions: There was no significant difference between the rates of R0 resections for PGC and DGC. Total gastrectomy can be performed with low postoperative morbidity and mortality. PGC and DGC represent the same tumor entity, and prognosis is similar, but due to more advanced tumor stages, the long-term survival is worse for patients with PGC than for those with DGC. Left retroperitoneal lymphadenectomy may be indicated for PGC.
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  • 43
    ISSN: 1530-0358
    Keywords: Fistula-in-ano ; Surgery ; Imaging ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Magnetic resonance imaging of fistula-in-ano has been shown to predict surgical anatomy accurately and identify complex features. In addition, fistula complexity has been correlated with poor outcome after surgical intervention. We investigated whether preoperative magnetic resonance imaging could predict clinical outcome after surgery for fistulous disease better than clinical examination under anesthetic. METHODS: Seventy patients with clinically suspected fistula-in-ano underwent preoperative dynamic contrast-enhanced magnetic resonance imaging before surgical exploration. Outcome was assessed at a minimum of one year after surgical exploration and correlated in a blinded fashion with the surgical and magnetic resonance grading of the severity of the fistulous disease. RESULTS: Of 70 patients, 12 were not operated on and 6 were lost to follow-up, making 52 patients eligible for analysis. Assessment by dynamic contrast-enhanced magnetic resonance imaging more accurately predicted outcome than the findings at initial surgical exploration. Dynamic contrast-enhanced magnetic resonance imaging had a sensitivity of 81 percent, specificity of 73 percent, and positive predictive value of 75 percent; surgery had a sensitivity of 77 percent, specificity of 46 percent, and positive predictive value of 59 percent. Surgical assessment of apparent disease severity bore no relation to final outcome. Dynamic contrast-enhanced magnetic resonance imaging could accurately predict whether patients were likely to have a satisfactory or unsatisfactory outcome after surgery. CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging better predicts clinical outcome of patients with fistula-in-ano than initial surgical exploration.
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  • 44
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    Diseases of the colon & rectum 43 (2000), S. 1227-1236 
    ISSN: 1530-0358
    Keywords: Rectal cancer ; Apoptosis ; p53 ; bcl-2 ; Prognosis ; Recurrence ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The aim of this study was to evaluate the prognostic value of the apoptotic index for recurrence and disease-free survival after curative surgery for rectal cancer, particularly in relation to clinicopathologic variables, p53− and bcl-2 expression. METHODS: Formalin-fixed, paraffin-embedded tissue samples of rectal carcinomas resected curatively within a five-year period were used (N=160). Apoptotic cells with fragmented DNA were detected by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphatase-biotin nick-end-labeling method. The ratio of apoptotic tumor cells (in percent) was classified into low apoptotic index (less than 10 percent) and high apoptotic index (10 percent or more). Immunohistochemical analysis was performed using monoclonal antibodies (DO-1 for p53 and clone 124 for bcl-2). Statistics included univariate and multivariate analysis, and survival was calculated using the Kaplan-Meier method. RESULTS: Seventy-five percent of tumors showed a low apoptotic index, and 25 percent had a high apoptotic index. No correlation was found between apoptotic index and International Union Against Cancer stage (P〉0.05). However, significant correlations were documented with histologic differentiation (mean apoptotic index, 5.74 percent in moderatelyvs. 3.98 percent in poorly differentiated carcinomas; P=0.0173), lymph node involvement (mean apoptotic index, 6.11 percent in pN1vs. 3.72 percent in pN2; P=0.0074), p53 status (mean apoptotic index, 6.26 percent in p53−vs. 4.42 percent in p53+; P=0.0085), and bcl-2 expression (mean apoptotic index, 5.13 percent in bcl-2−vs. 6.51 percent in bcl-2+; P=0.0418). Tumors of the lower rectum had a lower apoptotic index than those of the upper rectum (P=0.0277). Neither univariate nor multivariate analysis assessed apoptotic index as predictor of prognosis: Recurrence rates did not differ between tumors related to apoptotic index (22 percent with low apoptotic indexvs. 15 percent with high apoptotic index; P〉0.05), and no significant differences were found regarding survival (P〉0.05). On multivariate analysis, International Union Against Cancer stage (P=0.0002), p53 (P=0.0002), gender (P=0.0136), and bcl-2 (P=0.0243) were independent predictors of recurrence. These variables, except for bcl-2, were also independently related to disease-free survival. CONCLUSIONS: Reflecting tumor biology, apoptotic index as single variable showed no prognostic significance, whereas p53 was an independent predictor for both recurrence and survival, and bcl-2 was independently related to recurrence, but not to survival. Clinically, International Union Against Cancer stage and gender were independent prognostic factors after curative surgery for rectal cancer.
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  • 45
    ISSN: 1534-4681
    Keywords: Colorectal hepatic metastases ; Liver neoplasm ; Liver resection ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Hepatic resection is potentially curative in selected patients with colorectal metastases. It is a widely held practice that multiple colorectal hepatic metastases are not resected, although outcome after removal of four or more metastases is not well defined. Methods: Patients with four or more colorectal hepatic metastases who submitted to resection were identified from a prospective database. Number of metastases was determined by serial sectioning of the gross specimen at the time of resection. Demographic data, tumor characteristics, complications, and survival were analyzed. Results: From August 1985 to September 1998, 155 patients with four or more metastatic tumors (range 4–20) underwent potentially curative resection by extended hepatectomy (39%), lobectomy (42%), or multiple segmental resections (19%). Operative morbidity and mortality were 26% and 1%, respectively. Actuarial 5-year survival was 23% for the entire group (median 5 32 months) and there were 12 actual 5-year survivors. On multivariate analysis, only number of hepatic tumors (P = .005) and the presence of a positive margin (P = .003) were independent predictors of poor survival. Conclusions: Hepatic resection in patients with four or more colorectal metastases can achieve long-term survival although the results are less favorable as the number of tumors increases. Number of hepatic metastases alone should not be used as a sole contraindication to resection, but it is clear that the majority of patients will not be cured after resection of multiple lesions.
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  • 46
    ISSN: 1436-3305
    Keywords: Key words EGC ; Prognosis ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. During the 1970s, a special type of Gastric Cancer with excellent prognosis (early gastric cancer; EGC) was identified by the Japanese Research Society for Gastric Cancer. EGC has been defined as a tumor which invades the mucosa and/or submucosa, regardless of the lymph node status. Using this definition, we identified an initial phase of tumor development which could be treated both endoscopically and surgically. Methods. We examined 412 EGC patients, recruited between 1976 and 1999, with an average follow-up of 9 years. All tumors were classified according to the macroscopic and microscopic criteria proposed by the Japanese Society of Gastroenterological Endoscopy (JSGE) and Lauren, respectively. The infiltrative growth pattern was evaluated according to Kodama's classification. Only tumor-related death was considered as an end-point of interest for the survival analysis. Results. Submucosal tumors (P = 0.008), Pen A (see definition below) type disease (P = 0.0001), and lymph node-positive cancers (P = 0.0002) were significant prognostic factors on univariate analysis. Moreover, bivariate analysis showed that the worst prognosis, in terms of survival, was for patients with nodal involvment, submucosal invasion, and node-positive and Pen-A type cancer. The abbreviation Pen, penetrating, indicates a lesion with a diameter of less than 4 cm, which invades the submucosa diffusely. Pen A type EGC represents a subgroup of tumors which infiltrates the submucosa extensively, with nodular masses, causing the complete destruction of the muscularis mucosae. Conclusion. In our series, Pen A type was an important prognostic factor (hazard ratio; HR, 8.32; 95% confidence interval [CI], 3.49–19.86. For this reason, we believe it is important to evaluate the infiltration into the wall in all patients with EGC, paying particular attention to the growth pattern of the neoplasm. Moreover, submucosal Pen A type tumors had a considerably worse prognosis and this finding was reinforced when lymph node metastases coexisted. We suggest, therefore, that surgical treatment with at least a D2 lymphadenectomy is performed in all these patients, as the lesions must be considered to be advanced, no longer being EGC.
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  • 47
    ISSN: 1436-3305
    Keywords: Key words Tumor marker ; CEA ; CA19-9 ; Gastric cancer ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Background. This clinicopathological study evaluated the utility of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 as predictors of locoregional recurrence and long-term disease-free survival in patients with gastric cancer. Methods. During the period January 1989 to December 1994, 485 patients with primary gastric cancer were evaluated. Gastrectomies were performed in 434 patients. Prognostic factors were analyzed by the Kaplan-Meier method and multivariate analysis, using Cox regression. Results. Elevated serum CEA and CA19-9 levels were observed in 92 of the 485 patients (19.0%), and in 95 of the 435 patients (21.8%), respectively, and both markers were elevated in 29 of these 435 patients (6.7%). Elevated serum CEA and CA19-9 levels correlated well with lymph node metastasis, lymphatic invasion, vessel invasion, stage grouping, depth of invasion, and curability. Patients with elevated serum CEA levels were at significantly higher risk of having all recurrence factors than were those with normal serum CEA levels. Patients with elevated serum CA19-9 levels were at significantly higher risk of having peritoneal metastases and distant metastases than were those with normal serum CA19-9 levels. A significant difference in the cumulative survival curves of patients was demonstrated between those with elevated and those with normal serum CEA or CA19-9 levels, even for patients at the same disease stage (stage III). Patients with elevated levels of both markers had a significantly worse prognosis than patients in whom the levels of both markers were normal. In patients who underwent gastrectomy, elevated serum CEA levels either preoperatively or within 3 weeks after gastrectomy were associated with significantly worse prognosis than were normal levels. When the cutoff level of serum CEA was increased to 10 ng/ml, serum CEA, age, lymph node metastasis, and surgical stage grouping were selected as independent prognostic factors by multivariate analysis of 14 prognostic factors, using Cox regression. Conclusion. Serum CEA and CA19-9 levels provide additional prognostic information in patients with primary gastric cancer. In particular, an elevated serum CEA level provides additional prognostic information and is a useful indicator of curability in patients who undergo gastrectomy. Serum CEA level is an independent prognostic factor in patients with primary gastric cancer.
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  • 48
    ISSN: 1436-2813
    Keywords: Key Words Adenosquamous carcinoma ; Remnant stomach ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 59-year-old man found to have adenosquamous carcinoma of the remnant stomach which demonstrated rapid progression. The patient was admitted to our hospital to undergo surgery for a papillary tumor of the remnant stomach. Total resection of the remnant stomach with lymph node dissection was performed, and pathological examination confirmed a diagnosis of adenosquamous carcinoma with invasion into the muscularis propria and lymph node metastasis around the perigastric areas. Multiple liver metastases were found 6 months after the operation, for which a right hepatectomy was performed with curative intent; however, he died 2 months later due to lymphangitis carcinomatosa of the lung.
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  • 49
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    Trauma und Berufskrankheit 2 (2000), S. 78-85 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Marknagelung ; Femur ; Indikationen ; Keywords ; Intramedullary nailing ; Femur ; Indications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Intramedullary nailing is today the treatment of choice for femoral shaft fractures. The unreamed femoral nail (UFN) system combines the advantages of minimally invasive unreamed nailing with different proximal interlocking options. This means a reduced risk of systemic and local complications. The UFN offers several interlocking options, extending the indications for nailing especially in proximal femoral fractures. As part of a prospective multicentre study, the new AO femoral nail was evaluated in 365 cases treated at eight European and North American clinics. Follow-up rate was 82%. The fracture healing was uneventful in 95% of all cases. In the remaining 5% delayed healing, pseudarthosis, infections and malalignment were observed. This paper gives an overview of the current status of femoral nailing. The clinical findings recorded with the UFN in this clinic as one of those taking part in the AO prospective multicentre study are discussed.
    Notes: In der Behandlung von Femurschaftfrakturen ist heute die Marknagelung das Verfahren der Wahl. Im UFN-System finden sich die Vorteile der minimalinvasiven, unaufgebohrten Marknagelung mit den verschiedenen proximalen Verriegelungsoptionen vereint. Das Risiko von systemischen und lokalen Komplikationen wird bei gleichzeitig guter Versorgungsstabilität reduziert. Der unaufgebohrte Femurnagel bietet mit seinen Optionen der Standard-, der antegraden, der Spiralklingen- und der Miss-A-nail-Verriegelung gerade für proximale Frakturen stabile Versorgungsmöglichkeiten an. Der neue unaufgebohrte AO-Femurnagel wurde in 365 Fällen in einer prospektiven, multizentrischen Studie (Nachkontrollrate: 82%) von ¶8 Kliniken in Europa und Nordamerika evaluiert. In 95% der Fälle zeigte sich eine achsgerechte Ausheilung. Bei den restlichen 5% traten verzögerte Heilungen, Pseudarthrosen, Infektionen und Fehlstellungen auf. In der vorliegenden Arbeit wird ein Überblick über die derzeitigen Möglichkeiten der Femurmarknagelung auf der Basis der in unserer Klinik gewonnenen Erfahrungen gegeben. Die als teilnehmende Klinik an der Multizenterstudie erreichten Erkenntnisse werden diskutiert.
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  • 50
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    Trauma und Berufskrankheit 2 (2000), S. 134-147 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Okzipitale Kondylenfrakturen ; Gehenktenfrakturen ; Densfrakturen ; Atlantookzipitale und atlantoaxiale Dislokation ; Obere Halswirbelsäule ; Keywords ; Occipital condylar fractures ; Hangman’s fractures ; Dens fractures ; Atlanto-occipital and atlanto-axial dislocation ; Upper cervical spine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In contrast to the figures reported in the literature, according to which fractures of the occipital condyles are rare, we observed that such fractures were strikingly frequent among our patients. Moreover, isolated fractures of the lateral mass and the transverse process of atlas were observed, casting doubts on the low frequency reported for these too in the current literature. The clinical symptoms mainly reported in a wide variety of injuries of the upper cervical spine (C0–C2) are pain in the neck and difficulties in swallowing, and they do not provide any information about the type of injury. The methods of diagnosis used are usually limited to X-ray und computed tomography, nuclear spin resonance tomography (NMR) being undertaken only in special cases. Unstable occipital fractures of types III and IV (Jeanneret system) are treated by halo fixation. Unstable atlas fractures equivalent to dislocated Jefferson fractures could be largely anatomically repositioned by progressive traction in halo fixation. A maximum of 12 weeks’ immobilisation was needed for healing. Dens fractures of type II (Anderson system) are mainly treated with compression osteosynthesis, while type III is treated conservatively with halo fixation. In the case of hangman’s fractures of type II (Effendi) ventral spondylodesis C2/C3 is preferred. Atlanto-occipital and atlanto-axial dislocation require operative fusion.
    Notes: Im eigenen Patientengut fanden sich die in der Literatur als extrem selten angegebenen Frakturen der Okzipitalkondylen auffallend häufig. Auch nur vereinzelt beschriebene isolierte Frakturen der Massa lateralis sowie des Processus transversus atlantis wurden beobachtet, sodass Zweifel an deren Seltenheit aufkommen. Die klinische Symptomatologie der unterschiedlichsten Verletzungen der oberen Halswirbelsäule (C0–C2) beruht wesentlich auf der Angabe von Nackenschmerzen und Schluckbeschwerden und erlaubt keine Rückschlüsse auf die Art der Verletzung. Die Diagnostik beschränkt sich regelhaft auf das Nativröntgen sowie die Computertomographie, die Kernspintomographie bleibt Ausnahmefällen vorbehalten. Die Behandlung instabiler okzipitaler Kondylenfrakturen vom Typ III und IV nach Jeanneret erfolgt durch Halofixation. Instabile Atlasfrakturen, die den dislozierten Jefferson-Frakturen entsprechen, konnten durch sukzessive Traktion im Halofixateur jeweils weitgehend anatomisch reponiert werden und heilten bei maximal 12-wöchiger Ruhigstellung. Densfrakturen vom Typ II nach Anderson werden überwiegend mit Kompressionsosteosynthese, Densfrakturen vom Typ III dagegen konservativ (Halo) versorgt. Bei Gehenktenfrakturen vom Typ II nach Effendi wird die ventrale Spondylodese C2/3 bevorzugt. Atlantookzipitale und atlantoaxiale Dislokationen bedürfen der operativen Fusionierung.
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  • 51
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    Trauma und Berufskrankheit 2 (2000), S. 167-173 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Wirbelsäulenverletzung ; Thorakolumbale Wirbelsäule ; Kombinierte dorsoventrale ¶Stabilisierung ; Spätrekonstruktion ; Operationsindikationen ; Keywords ; Spinal injuries ; Thoracolumbar spine ; Combined dorso-ventral stabilizing procedure ; Secondary reconstruction ; Indications for surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The majority of unstable thoracic and lumbar fractures can be successfully treated by dorsal instrumentation with an internal fixation device providing angular stability. A supplementary ventral fusion involves severe additional surgical trauma and should be restricted to selected indications such as injuries with significant narrowing of the spinal canal that cannot be corrected from a dorsal approach, highly unstable lesions and old fractures. The possibility of secondary reconstructions should be kept in mind.
    Notes: Die Mehrzahl der instabilen Frakturen der Brust- und Lendenwirbelsäule kann erfolgreich durch dorsale Instrumentation mit winkelstabilen Fixationssystemen behandelt werden. Eine ergänzende ventrale Spondylodese geht mit einem erheblichen zusätzlichen Operationstrauma einher und sollte auf ausgewählte Indikationen, wie Verletzungen mit einer signifikanten Einengung des Spinalkanals, die von dorsal nicht zu beseitigen ist, hochinstabile Läsionen und veraltete Frakturen, beschränkt werden. Die Möglichkeiten einer Spätrekonstruktion sollten nicht außer Acht gelassen werden.
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  • 52
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    Trauma und Berufskrankheit 2 (2000), S. 195-200 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; O-Bein ; Meniskusschaden ; Schadensanlage ; Keywords ; Bowlegs ; Meniscal damage ; Predisposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In expert medical evidence it is common to encounter the opinion in that strenuous occupational exposure has less influence on meniscal damage than deviations of the ¶leg axis. Since damage to the medial meniscus is more common than damage to the ¶lateral meniscus, the main issue requiring discussion is the significance of bowlegs in relation to the medial meniscus. The biomechanical hypothesis of the essential relevance of bowlegs to medial meniscal damage is plausible only at first glance; in fact there is no epidemiologic evidence to support it and there are numerous arguments against it. According to present knowledge, in legally binding assessments of meniscal damage bowlegs are not seen as a contributory cause, but at most as a factor in a predisposition to such damage.
    Notes: Immer wieder wird in Gutachten die Auffassung vertreten, berufsbedingten Einflüssen auf den Meniskus käme eine geringere Bedeutung zu als einem Beinachsenfehler. Da Innenmeniskusschäden häufiger sind als ¶solche des Außenmeniskus, stellt sich damit vornehmlich die Frage nach der Bedeutung des O-Beins für den Innenmeniskus. Nur auf den ersten Blick erweist sich der biomechanische Ansatz plausibel, dass die O-Bein-Achse die wesentliche Ursache für einen ¶Innenmeniskusschaden liefere. Tatsächlich finden sich zu dieser Hypothese nicht nur keine epidemiologischen Bestätigungen, sondern zahlreiche Gegenargumente. Nach heutigem Wissensstand ist dem O-Bein im Rahmen der sozialrechtlichen Beurteilung eines Meniskusschadens nicht die Bedeutung einer konkurrierenden Mitursache, ¶sondern höchstens die einer Schadensanlage zuzuordnen.
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  • 53
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    Trauma und Berufskrankheit 2 (2000), S. 220-222 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Polytrauma ; Chirurgische Forschung ; Immunologie ; Keywords ; Polytrauma ; Surgical research ; Immunology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Trauma is the leading cause of death among people aged up to 40 years. The treatment ¶of polytraumatised patients consumes a large proportion of health care resources and demands sophisticated medical support. The number of trauma deaths has ¶been significantly reduced as a result of new medical knowledge. Nonetheless, one of the main dangers for such multiply injured patients is the risk that reactive multi-organ failure (MOF) may develop; this is induced by a cascade of immunologic disorders. Up to now, research has not made it possible for ¶us to understand the immunologic changes that follow trauma in full and to develop new therapeutic strategies. A new approach is the analysis of the Th1/Th2 ratio of peripheral lymphocytes. Modulation of this ratio is discussed as a new treatment goal, but the results obtained in animal models have yet to be verified in clinical studies before they can be accepted as pathophysiologic dogma. Some of the most important missions of surgical research are therefore to test existing modes against clinical reality, create a body of basic knowledge oriented to clinical practice, to confirm immunologic theories or ¶define new ones in trauma patients, and to test new therapeutic strategies in human models by means of clinical studies.
    Notes: Das Trauma stellt in der Altersgruppe bis ¶40 Jahre die Haupttodesursache dar. Die Versorgung polytraumatisierter Patienten stellt höchste Ansprüche sowohl in medizinischer als auch in ökonomischer Hinsicht. Durch neue medizinische Erkenntnisse konnte die Überlebensrate dieser Patienten verbessert werden. Dennoch stellt das trauma- und mikrobiell induzierte fortschreitende reaktive Multiorganversagen (MOF) heute ein Hauptrisiko der schwerstverletzten Patienten dar. Eine wesentliche Ursache dafür ist eine posttraumatisch entstehende Dysbalance immunologischer Mediatoren und Reaktionen. Trotz intensiver Forschungsmaßnahmen ist es bisher nicht gelungen, die immunologischen Veränderungen beim Polytrauma in seiner Gesamtheit zu verstehen und daraus therapeutische Vorgehensweisen zu entwickeln. Eine neue Möglichkeit bietet die Analyse des Verhältnisses von Th1- und Th2-ähnlichen Zytokinprofilen von Leukozyten. Die Modulation dieses Verhältnisses könnte ein mögliches therapeutisches Ziel werden, wobei sich die tierexperimentellen Ergebnisse erst auf das Humanmodell übertragen lassen müssen. Darin liegt jedoch auch das Dilemma der chirurgischen Forschung: ¶Zu schnell werden tierexperimentelle und In-vitro-Befunde übernommen und persistieren als pathophysiologische Dogmen. ¶Es ist daher die Aufgabe der chirurgischen Forschung, bestehende Modellvorstellungen an der klinischen Realität zu messen, klinikorientieres Grundlagenwissen zu schaffen, immun-pathophysiologische Modellvorstellungen bei Traumapatienten zu verifizieren oder neu zu definieren und therapeutische Konzepte in klinischen Studien zu überprüfen.
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  • 54
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    Trauma und Berufskrankheit 2 (2000), S. S154 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Hinteres Kreuzband ; Isolierte Ruptur ; Therapie ; Prognose ; Key words ; Posterior cruciate ligament ; Isolated tears ; Treatment ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The treatment of injuries to the PCL is still controversial. There are still no answers to many questions on the biomechanics of PCL, the natural history of PCL injury, the surgical technique of PCL reconstruction and the biology of PCL healing. It is well established that primary repair of bony avulsions of the PCL provides good static and functional results. PCL tears should also be treated surgically in combined knee ligament injuries. For isolated midsubstance tears of the PCL, however, no prospective randomised long-term studies are available to date demonstrating that surgical treatment with current techniques leads to better results than nonoperative, functional treatment. Nonoperative management is advocated because the knee instability following isolated PCL midsubstance tear is only moderate, the natural history has been seen to end in acceptable functional stability, knee proprioception is preserved, and the incidence of late osteoarthritis is low.
    Notes: Zusammenfassung Die Behandlung von Rupturen des hinteren Kreuzbands wird international noch immer kontrovers diskutiert. Zahlreiche Fragen zur funktionellen Anatomie, zum Spontanverlauf nach Ruptur, zur chirurgischen Technik sowie zum Heilungsverlauf sind unbeantwortet. Gesichert ist, daß die primäre operative Versorgung von knöchernen Ausrissen des hinteren Kreuzbands zu guten Ergebnissen führt. Bei kombinierten Knieinstabilitäten sollte das verletzte hintere Kreuzband auch operativ versorgt werden. Für die isolierte, interligamentäre Ruptur des hinteren Kreuzbands konnte bisher jedoch mit keiner prospektiven, randomisierten Langzeitstudie bewiesen werden, daß die heutigen Operationsverfahren reproduzierbar zu besseren Ergebnissen führen als die konservativ-funktionelle Behandlung. Für die konservative Therapie sprechen die nur mäßige Instabilität nach isolierter Ruptur des hinteren Kreuzbands, der günstige Spontanverlauf und der Erhalt der Propriozeption des Kniegelenks sowie die im Verlauf nur geringe Arthroserate.
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  • 55
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    Trauma und Berufskrankheit 2 (2000), S. 2-10 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Beckenring ; Anatomie ; Biomechanik ; Keywords ; Pelvic ring ; Anatomy ; Biomechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Treatment of pelvic lesions can only be successful if one has an anatomical and biomechanical understanding of the physiological flux of force from the neck of the femur via the acetabular fossa to the sacroiliac joint. Not only the pelvic bone, but also the ligaments, e. g. the sacroiliac ligaments, have a particularly important support function. For assessing stability and classifying the traumatic patterns it is helpful to use Pennal’s classification [28], which takes the direction of the action of force into account. Three basic forms can be distinguished: anteroposterior compression, lateral compression and vertical avulsion. The extent of the traumatic pattern can be used to differentiate between the subtypes that can be treated conservatively and those that require surgical treatment. The biomechanics and the traumatic patterns are described clearly and with illustrations.
    Notes: Voraussetzung einer erfolgreichen Behandlung einer Beckenverletzung ist das anatomische und biomechanische Verständnis des physiologischen Kraftflusses vom Schenkelhals über die Gelenkpfanne zum Sakroiliakalgelenk. Eine wichtige Trägerfunktion haben nicht nur der Beckenknochen, sondern auch die ligamentären Strukturen, besonders die Ligg. sacroiliaca dorsalia. Für die ¶Stabilitätsbeurteilung und Klassifikation der Verletzungsmuster hat sich die Einteilung nach Pennal et al. bewährt, die die Richtung der Krafteinwirkung berücksichtigt. Es lassen sich 3 Grundformen unterscheiden: die a.-p.-Kompression, die laterale Kompression und die vertikale Abscherung. Je nach Ausmaß des Verletzungsmusters lassen sich Untertypen unterscheiden, die konservativ behandelt werden können oder eine operative Therapie erfordern. Die Biomechanik und die Verletzungsmuster werden anschaulich und reichlich illustriert beschrieben.
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  • 56
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    Trauma und Berufskrankheit 2 (2000), S. 387-389 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Koordinator ; Bergmannstrost ; Rehabilitation ; Keywords ; Coordinator ; Bergmannstrost ; Rehabilitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: While the medical care of accident and emergency patients treated by members of our professional association, especially in clinics run by the professional association, is recognized as being of a high standard, in practice the interface between those directly involved in this treatment and the administrative offices responsible within the association has been found to offer room for optimization on both sides. To this end, a coordinator for professional assistance has been appointed at the “Bergmannstrost” clinic run by the professional association. The new coordinator’s office is both a source of information and a support centre, providing assistance and advice for the medical staff of the clinic and also for the administrative staff responsible in the professional association’s offices. The coordinator, who is excellently well aware of the requirements and options for control within the treatment offered by the professional association, gives advice and makes sure that the various matters raised are routed quickly and directly to the correct offices. Looking back over almost 2 years’ experience, optimization of the interface seems to have been successfully achieved. The resultant tightening of the decision-making process has led to accelerated processing of concerns and positive effects on the costs of rehabilitation treatment.
    Notes: Während die medizinische Versorgung Unfallverletzter im bg-lichen Heilverfahren und gerade auch in den BG-Kliniken einen anerkannt hohen Standard aufweist, bot in der Praxis die Schnittstelle zu der Sachbearbeitung der Berufsgenossenschaften wechselseitig Optimierungspotenzial. Dem wurde durch die Installation einer Berufshilfekoordinatorin in den BG-Kliniken Bergmannstrost Rechnung getragen. Einer Informations- und Anlaufstelle also, die gleichermaßen dem medizinischen Personal der BG-Klinik als auch der Sachbearbeitung in den Berufsgenossenschaften als Anlauf- und Beratungsstelle dient. Die Koordinatorin, die exzellent mit den Anforderungen und Steuerungsmöglichkeiten im bg-lichen Heilverfahren vertraut ist, berät oder sorgt dafür, dass die jeweiligen Belange schnell und auf direktem Weg an der richtigen Stelle ankommen. Rückblickend auf einen Erfahrungszeitraum von knapp 2 Jahren scheint die Optimierung der Schnittstelle gelungen zu sein. Durch die dadurch ermöglichte Straffung von Entscheidungsprozessen konnten neben Beschleunigungseffekten positive Wirkungen hinsichtlich der Rehabilitationskosten beobachtet werden.
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  • 57
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    Trauma und Berufskrankheit 2 (2000), S. 28-38 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Beckenverletzung ; Begleitverletzung ; Diagnostik ; Therapie ; Algorithmus ; Keywords ; Pelvic trauma ; Concomitant lesions ; Diagnosis ; Therapy ; Algorithm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The injuries that typically accompany pelvic fractures are lesions of the urogenital tract, the lumbosacral plexus, and the retroperitoneal and intra-abdominal organs. The prognosis depends heavily on early recognition of the abdominal- and retroperitoneal injuries, which are frequently a primary threat to vital functions. Missing these injuries would be very serious, as the mortality with early diagnosis and adequate treatment is normally low; according to the results reported in the literature, delayed therapy leads to increasing mortality rates of up to 80%. Experience in trauma centres has shown that for complete ascertainment of accompanying injuries it is necessary to perform a systematic diagnosis according to a fixed algorithm. The treatment of the concomitant injuries accompanying a complex pelvic trauma is fundamentally different from the treatment of patients with isolated injuries. A high survival rate with a low postoperative complication rate cannot be achieved except with specialist surgical management tailored to the primary life-threatening lesions. After determination and recording of the injury pattern a therapy concept must be made at once. A trauma algorithm can be helpful when treatment is selected. Step-by-step treatment with several operative phases alternating with recovery and stabilization periods under intensive care conditions has proved worthwhile.
    Notes: Typische Begleitverletzungen von Beckenfrakturen sind Verletzungen des Urogenitaltrakts, des Plexus lumbosacralis und intraabdominaler Organe. Entscheidend für die Prognose ist das rechtzeitige Erkennen v. a. der häufig primär vital gefährdenden Abdominal- und Retroperitonealverletzungen. Das Übersehen dieser Verletzungen ist besonders tragisch, da bei rechtzeitiger Diagnostik und adäquater Versorgung die Letalitätsrate in der Regel gering ist; bei verzögerter Therapie resultieren nach den Angaben in der Literatur Letalitätsraten bis zu 80%. Die Erfahrung in Traumazentren hat gezeigt, dass zur vollständigen Erfassung der Begleitverletzungen die systematische Diagnostik nach einem festgelegten Algorithmus erfolgen sollte. Die Behandlung der Begleitverletzungen im Rahmen eines komplexen Beckentraumas unterscheidet sich prinzipiell von der bei Monoverletzten. Voraussetzung für eine hohe Überlebensrate mit geringer postoperativer Komplikationsrate ist ein prioritätenorientiertes chirurgisches Vorgehen. Nach Erfassung des Verletzungsmusters muss bereits initial ein Therapiekonzept erstellt werden. Zur Entscheidungsfindung kann ein Traumaalgorithmus herangezogen werden. Es hat sich eine abgestufte Versorgung mit mehreren operativen Phasen und zwischengeschalteten Erholungs- und Stabilisierungsphasen unter Intensivbedingungen bewährt.
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  • 58
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    Trauma und Berufskrankheit 2 (2000), S. 60-64 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Lungenversagen ; Bauchlagerung ; Oxygenierung ; Prophylaktische Effekte ; Keywords ; Pulmonary failure ; Prone positioning ; Oxygenation ; Prophylactic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Despite positive reports on the use of alternating prone and supine positioning in patients with respiratory failure, this therapy is now rarely used. Prone positioning leads to substantially improved oxygenation, a shorter duration of mechanical ventilation and lowered mortality. Because of the good results in patients with acute respiratory failure, in 1991 we also started using the prone position as a primary prophylactic procedure in patients in whom oxygenation is not yet impaired but who are at risk of pulmonary failure. By this means we have achieved a reduction in the incidence of pulmonary failure from 31.6% to nil in 124 trauma patients, a result confirmed by comparison of the results in 100 patients treated without prone positioning. Investigations also showed a decreased intrapulmonary shunt fraction, recruitment of collapsed alveoli in the absence of negative side effects on mechanical ventilation parameters and hemodynamics while patients were in the prone position. Therefore, we feel that use of alternating prone and supine positioning, especially prophylactically, should be highly recommended.
    Notes: Obgleich positive Berichte über die Anwendung der Bauchlagerung beim Lungenversagen vorliegen, hat ihr Einsatz noch keine weite Verbreitung gefunden. Die beeindruckenden Effekte dieser einfachen Behandlungsform in Form der Verbesserung der Oxygenierung, Verkürzung der Beatmungsdauer und gesenkten Letalität des ARDS haben uns veranlasst, die Wechsellagerung auch primär, d. h. bei noch nicht gestörter Lungenfunktion, als prophylaktische Maßnahme einzusetzen. Hierdurch konnte im Gegensatz zu anderen Therapiestrategien eine drastische Senkung der Inzidenz des Lungenversagens erreicht werden. Durch ¶die Auswertung der Daten von 304 mittels Wechsellagerung behandelten Patienten und die Gegenüberstellung einer Vergleichsgruppe von 100 Patienten konnten diese ¶Beobachtungen belegt werden. Weitere Untersuchungen zeigten die Reduktion der intrapulmonalen Shunt-Fraktion, die hämodynamische Stabilität und die Wiederöffnung kollabierter Alveolen während der Bauchlagerung. Eine rasche Verbreitung der Wechsellagerung, insbesondere des frühzeitigen, prophylaktischen Einsatzes, ist deshalb im Interesse der Patienten zu fordern.
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  • 59
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    Trauma und Berufskrankheit 2 (2000), S. 93-100 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Humerusschaftfraktur ; Marknagelung ; UHN ; Biologische Osteosynthese ; Keywords ; Humeral shaft fracture ; Intramedullary ¶nailing ; UHN ; Biological osteosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Intramedullary stabilization is one alternative to plate osteosynthesis for the treatment of humeral shaft fractures. In the last 50 years many wire and nail systems have been developed for this purpose and used in clinical practice, many of which have involved problems with rotational stability. One of the recently developed nails is the unreamed humerus nail (UHN) for antegrade and retrograde insertion. The nail system and the operative technique are presented and discussed, as are the results of a multicentre study and the author’s own results.
    Notes: Die intramedulläre Stabilisierung von Oberarmschaftfrakturen ist eine Behandlungsalternative zur etablierten Plattenosteosynthese. Hierfür wurden in den letzten 50 Jahren viele Draht- und Nagelsysteme entwickelt, wobei die Technik der Verriegelung des Implantats zur Rotationssicherung der Fraktur entscheidend ist. Eine der neueren Entwicklungen stellt der solide Humerusnagel dar (UHN), der retrograd und antegrad eingebracht werden kann. Nagelsystem, Operationstechnik und Ergebnisse einer Multizenterstudie sowie eigene Ergebnisse mit Komplikationsanalyse werden dargestellt und verglichen.
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  • 60
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Pseudarthrose ; Fehlstellung ; Marknagelung ; Keywords ; Non-union ; Deformity ; Intramedullary ¶nailing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Gentle intramedullary reaming and stabilization can provide fast bone consolidation in cases of delayed fracture healing and hypertrophic non-unions. The decision onwhether or not intramedullary nailing is indicated must always be made with reference to the individual situation. An analysis of our own cases revealed bony healing in hypertrophic non-unions of femoral shaft fractures in 93% and in 94% of tibial shaft fractures after reamed intramedullary nailing. In selected cases of axial or rotational deformities or length discrepancy of the femur and tibia a correction osteotomy can be performed with intramedullary nailing. If it is necessary to expose the non-union area decortication can be performed and rotation stabilization can be applied in addition to the intramedullary nailing.
    Notes: Bei verzögerter Knochenbruchheilung oder Pseudarthrose bzw. im Rahmen von Korrekturosteotomien bei Schaftfrakturen ist das Verfahren der intramedullären Stabilisierung in seinen verschiedenen Anwendungstechniken häufig die geeignete Methode. Die Indikation für eine intramedulläre Stabilisierung muss an den jeweils individuell vorliegenden Gegebenheiten orientiert sein. Die Technik des Aufbohrens, sofern vorsichtig und schonend angewendet, führt entsprechend klinischer Erfahrungen in einer überschaubaren Zeit, ganz besonders bei hypertrophen Pseudarthrosen, zur knöchernen Überbrückung. Dabei wird die Rolle des Bohrmehls immer noch diskutiert. Bei liegendem Marknagel können auch eine lokale Dekortikation und eine rotationsstabilisierende Platte die Ausheilung begünstigen. Ausgewählte Fälle von Achsenfehlern bzw. Längendifferenzen, speziell die Korrektur von Torsionsabweichungen oder der Segmenttransport mit Kallotaxis, können mit Hilfe der Marknagelung stabilisiert werden.
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  • 61
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Ventrale Spondylodese ; Funktionelles ¶Ergebnis ; Untere Halswirbelsäule ; Keywords ; Ventral spondylodesis ; Functional results ; Low cervical spine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: A total of 58 patients were examined to determine the functional results in the cervical spine an average of 5.3 years after ventral spondylodesis. After questioning and physical examination the function was assessed by functional radiographs (according to Penning) and dynamic 3-D motion analysis. In 54% of cases the patients reported no subjective restrictions of their mobility or only slight restrictions, while 22% experienced moderate to marked limitations in their professional life and 28%, in their activities of daily living, but 84% of the patients were nonetheless still engaging in the same types of sport as before. The clinical examination revealed the following ranges of movement (MV ± SD) in the cervical spine: anteflexion 37°± 19°; retroflexion 46°± 21°; lateral bending 49°± 24°; and rotation in neutral position 112°± 42°. The functional radiographs showed smaller values: anteflexion 24.2°± 11°; and retroflexion 25.4°± 14°. The 3-D motion analysis confirmed a restriction compared with the normal collective: 20% in the sagittal plane, 13% in the frontal plane, 18% with rotation in the neutral position, 15% in maximal anteflexion and 26% in maximal retroflexion of the cervical spine. The function of the cervical spine is independent of age, sex and extent of the spinal fusion; restrictions tend to be more pronounced with increasingly caudally located spondylodeses. Compensatory hypermobility of the neighbouring segments cannot generally be confirmed.
    Notes: Durchschnittlich 5,3 Jahre nach ventraler Spondylodese wurden 58 Patienten hinsichtlich des funktionellen Ergebnisses der Halswirbelsäule nachuntersucht. Nach Befragung und klinischer Untersuchung wurde die Funktion mit Hilfe von Funktionsaufnahmen (nach Penning) und dynamischer 3D-Bewegungsanalyse beurteilt. Subjektiv keine oder geringe Einschränkungen der HWS-Beweglichkeit bemerkten 54% der Patienten, im Beruf sind 22% und im Alltag 28% mäßig bis stark eingeschränkt, dennoch üben 84% alte sportliche Aktivitäten aus. Die klinische Untersuchung ergab folgende Bewegungsauslenkungen (MW ± SD): Anteflexion: 37 ± 19°, Retroflexion: 46 ± 21°, bilaterale Seitneigung: 49 ± 24°, Rotation in Neutralstellung: 112 ± 42°. Die Funktionsaufnahmen zeigten geringere Werte: Anteflexion: 24,2 ± 11° und Retroflexion: 25,4 ± 14°. Die 3D-Bewegungsanalyse bestätigte eine Einschränkung gegenüber dem Normalkollektiv: in der Sagittalebene 20%, in der Frontalebene 13%, bei Rotation in der Neutralstellung 18%, in der maximalen Anteflexion 15% und in der maximalen Retroflexion 26%. Die Funktion der HWS war vom Alter, vom Geschlecht und von der Ausdehnung der Fusion unabhängig; kaudaler gelegene Spondylodesen zeigten tendenziell größere Einschränkungen. Kompensatorische Hypermobilitäten der benachbarten Segmente konnten im Regelfall nicht bestätigt werden.
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  • 62
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Lendenwirbelsäule ; Zusammenhangsbegutachtung ; Bandscheibenvorfall ; Osteoporose ; Keywords ; Lumbar spine ; Appraisal of causality ; Disc prolapse ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: It is rare for structural injuries to arise in the setting of “lifting accidents”. Of those that do occur, compression fractures of the vertebral body in patients with pre-existing osteoporosis are the most common. In these cases, the force exerted by the trauma needs to be weighed against the severity of the osteoporosis for a decision on the causality to be reached. The recognition of a lumbar disc prolapse can only be seriously considered as a result of such an accident if concomitant bony or ligamentous injuries are present. Functional impairments caused by lumbar strains must be differentiated from the natural course of lumbar diseases not related to the accident. With the criteria of causality applicable to workers’ compensation in Germany as a basis, algorithms for the appraisal of causality in back problems associated with lifting accidents are presented.
    Notes: Strukturelle Verletzungen bei Verhebetraumen sind selten. Wenn sie auftreten, handelt es sich meist um Kompressionsbrüche der Wirbelkörper bei vorbestehender Osteoporose. Hier ist unter Berücksichtigung der Höhe der unfallbedingten Krafteinwirkung und der Ausprägung der Osteoporose abzuwägen, ob die Osteoporose allein wesentlich ist oder ob eine wesentliche Teilursächlichkeit des Unfalls vorliegt. Die Anerkennung eines Bandscheibenvorfalls an der Lendenwirbelsäule als Unfallfolge kommt nur dann ernsthaft in Betracht, wenn begleitende knöcherne oder begleitende Bandverletzungen vorliegen. Funktionseinschränkungen aufgrund von Zerrungen und Stauchungen sind vom natürlichen Verlauf unfallunabhängiger Wirbelsäulenerkrankungen abzugrenzen. Ausgehend von den Kausalitätskriterien der gesetzlichen Unfallversicherung werden Algorithmen zur Zusammenhangsbegutachtung nach so genannten Verhebetraumen dargestellt.
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  • 63
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Wunddrainage ; Keimbesiedlung ; Keywords ; Wound drainage ; Bacterial contamination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: A clinical study included an investigation of which factors influence bacterial contamination of Redon drainage systems and therefore, possibly, of the wound. In 200 patients who had undergone aseptic operations on the extremities bacterial cultures were taken from the secretions in the drainage tube and the drainage bottle and from the tip of the drain. Bacterial contamination of Redon drainage systems was seen in 25% of the aseptic procedures that were performed without any intra- or perioperative use of antibiotics (n = 100). When antibiotics were administered a statistically significant decrease in bacterial contamination, to 11%, was achieved. The addition of antibiotics to the operative irrigation solution alone resulted in a reduction of bacterial contamination of the drainage system to 9% (statistically significant). On the basis of our investigations it can be assumed that the bacterial contamination arises from the wound itself, but also externally from bacteria along the drain and through disconnection.
    Notes: Im Rahmen einer klinischen Untersuchung wurde der Frage nachgegangen, welche Faktoren die Keimbesiedlung in den Redon-Drainage-Systemen und damit evtl. auch der Wunde beeinflussen. Bei 200 Patienten mit aseptischen Operationen im Bereich der Extremitäten erfolgte die bakteriologische Untersuchung von Sekret aus dem Redon-Drain, der Drainageflasche und der Redon-Spitze. Redon-Drainage-Systeme weisen bei aseptischen Eingriffen (n = 100) ohne intra- oder perioperativen Antibiotikaeinsatz in 25% eine Keimbesiedlung auf. Diese lässt sich durch Gabe von Antibiotika (n = 100) statistisch signifikant auf 11% reduzieren. Dabei führt der alleinige Zusatz von Antibiotika zur Operationsspülflüssigkeit zur Reduzierung der Keimbesiedlung des Drainagesystems auf 9% (statistisch signifikant). Aufgrund der eigenen Untersuchungen kann davon ausgegangen werden, dass die Keimbesiedlung aus der Wunde selbst, aber auch von extern entlang des Drains sowie durch Diskonnektion erfolgt.
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  • 64
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    Trauma und Berufskrankheit 2 (2000), S. 232-238 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Handwurzelknochen ; Mondbein ; Mondbeinnekrose ; STT-Arthrodese ; Entfernung der proximalen Handwurzelreihe ; Radiusverkürzungsosteotomie ; Keywords ; Carpal bones ; Lunate ; Kienböck’s disease ; STT arthrodesis ; Proximal row carpectomy ; Radial shortening osteotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The etiology of Kienböck’s disease is still not definitely known. Left untreated, the disease inevitably leads to carpal collapse. Conventional X-ray and MRI with gadolinium should be used for diagnosis if lunate necrosis is suspected on the basis of a clinical examination. CT scans are helpful for differentiation between Lichtman’s stages and for assessment of the cartilaginous surfaces of the carpal joints. A uniform classification system is an important requirement for comparison of the therapeutic effects. In the early stages joint leveling procedures to regulate the transmission forces acting on the lunate can lead to sucessful results; partial wrist arthrodesis or proximal row carpectomy are reliable treatments in advanced stages of the disease. In stage IV (Lichtman) wrist denervation can be used as a palliative operation. Total wrist fusion represents the last line of defense in stage IV when radiocarpal arthrosis is present.
    Notes: Die Ätiologie der Lunatumnekrose ist weiterhin nicht endgültig geklärt. Unbehandelt führt die Erkrankung zum karpalen Kollaps. Besteht der klinische Verdacht auf eine beginnende Mondbeinnekrose, stehen neben den zunächst durchzuführenden konventionellen Röntgenaufnahmen die Magnetresonanztomograpie mit Gadolinium als Kontrastmittel zur Diagnostik zur Verfügung. Zur Abgrenzung der Stadien nach Lichtman und Beurteilung der karpalen Gelenkverhältnisse ist die Computertomographie hilfreich. Um den Effekt therapeutischer Bemühungen beurteilen zu können, ist eine einheitliche Stadieneinteilung wichtig. In den niedrigen Stadien können niveauregulierende Operationsverfahren zum Erfolg führen, in den fortgeschrittenen Stadien können durch Teilfusionen an der Handwurzel oder Entfernung der proximalen Handwurzelreihe gute Ergebnisse erzielt werden. Im Stadium IV nach Lichtman sind meist Palliativmaßnahmen wie die Handgelenkdenervation oder als letzte chirurgische Option die Komplettversteifung des Handgelenks bei bestehender Radiokarpalarthrose erforderlich.
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  • 65
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    Trauma und Berufskrankheit 2 (2000), S. 240-248 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Komplexe Schultergürtelverletzung ; Diagnostik ; Therapie ; Interdisziplinäres ¶Management ; Keywords ; Complex shoulder girdle trauma ; Diagnosis ; Therapy ; Interdisciplinary management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The particular injury pattern of complex joint trauma means that a standardized operative procedure would be difficult to devise and an individual therapy plant is therefore essential for each patient. One of the main problems consists in the recognition and adequate treatment of associated vascular and neural lesions. The treatment of a complex joint trauma makes extremely high demands on the trauma-team in terms of both diagnostis and therapy and is an interdisciplinary challenge. On the basis of a detailed literature search and evaluation of the procedures we have adopted in sample cases, we suggest an algorithm for interdisciplinary management of severe combination injuries of the shoulder region.
    Notes: Die Problematik des komplexen Gelenktraumas besteht darin, dass aufgrund des besonderen Verletzungsmusters ein standardisiertes operatives Vorgehen erschwert und deshalb ein individuelles Therapiekonzept essenziell ist. Ein Hauptproblem besteht in ¶der Erkennung und der adäquaten Behandlung assoziierter Gefäß- und Nervenläsionen. Die Behandlung eines komplexen Gelenktraumas stellt höchste diagnostische und therapeutische Ansprüche an das Traumateam und bedeutet eine interdisziplinäre Herausforderung. Aufgrund einer eingehenden Literaturrecherche und der Auswertung des eigenen Vorgehens anhand exemplarisch ausgewählter Fälle wird versucht, einen Algorithmus der interdisziplinären Komplexversorgung schwerer Kombinationsverletzungen der Schulterregion zu erstellen.
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  • 66
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    Trauma und Berufskrankheit 2 (2000), S. 255-262 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Traumatische Schultererstluxation ; Begleitverletzungen ; Primäre arthroskopische Stabilisierung ; Ergebnisse ; Keywords ; Primary traumatic dislocation ; Shoulder ; Concomitant lesions ; Arthroscopic Bankart repair ; Results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Traumatic dislocation of the shoulder is caused by a high- or low-velocity trauma and leads to age-dependent soft tissue injuries. Concomitant bony and nervous injuries are more common than is generally expected. Adequate treatment, in addition to reduction, involves a detailed diagnostic and therapeutic strategy to prevent not only shoulder instability but also functional impairments. Rotator cuff tears in the elderly are still an unsolved problem, and the outcome is mostly poor even after surgery. With a view to lowering the recurrence rate, for acute dislocation of the shoulder in young patients an arthroscopic Bankart suture repair should be considered.
    Notes: Die traumatische Schulterluxation ist eine durch Gewalteinwirkung entstandene Gelenkverletzung mit altersabhängigen Schädigungsmustern. Begleitende Weichteil-, knöcherne und neurologische Verletzungen sind häufiger als oft angenommen. Die Behandlung erfordert über die rasche und schonende Reposition hinaus ein differenziertes diagnostisches und therapeutisches Vorgehen, um nicht nur eine posttraumatische Instabilität, sondern auch ein funktionelles Defizit zu verhindern. Rotatorenmanschettenrupturen beim älteren Patienten sind weiterhin ein ungelöstes Problem und haben auch nach operativer Behandlung eine relativ schlechte Prognose. Die sofortige arthroskopische Lavage bzw. Stabilisierung der Labrumläsion beim jungen Patienten ist im Hinblick auf die Senkung der Rezidivrate zu empfehlen.
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  • 67
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Distale Humerusfraktur ; Erwachsene ; Aktuelle Therapie ; Ergebnisse ; Keywords ; Distal humerus fracture ; Adults ; Current concepts ; Results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: There are not many fracture locations for which there is a greater degree of consensus on treatment regimens in the world than there are for the distal end of the humerus. The declared aim is anatomic reduction and stable internal fixation with early functional aftercare. Olecranon osteotomy is essential for access in the management of complete intra-articular fractures. Despite the standardized principles of surgical technique good clinical results are still elusive. Among 34 patients with an intra-articular fracture treated operatively good or excellent results were achieved in only 63%. The lack of new therapeutic strategies probably means that the surgeon’s skills are more important than in the treatment of fractures at other locations.
    Notes: Die Behandlungsstrategie bei distalen Humerusfrakturen ist allgemein akzeptiert und hat sich in den letzten 15 Jahren nicht wesentlich verändert. Das erklärte Ziel bleiben eine anatomische Reposition und stabile Osteosynthese mit frühfunktioneller Nachbehandlung. Bei kompletten intraartikulären Frakturen ist der Zugang über eine Olekranonosteotomie notwendig. Unsere eigenen Ergebnisse mit nur 63% guten und sehr guten Resultaten nach B- und C-Verletzungen (34 Patienten) sind nicht befriedigend. Trotz weltweit anerkannter standardisierter Operationstechnik stellt die Verbesserung der klinischen Resultate eine bleibende Herausforderung dar und ist bei zurzeit fehlenden Neuerungen in der operativen Technik u. a. nur durch die Vermeidung individueller Fehler zu erreichen.
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  • 68
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    Trauma und Berufskrankheit 2 (2000), S. 313-319 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Distale Radiusfraktur ; Differenzierte Therapieentscheidung ; Kirschner-Draht-Spickung ; Ergebnisse ; Keywords ; Distal radius fracture ; Tailored therapy decision ; Outcome ; Kirschner wiring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Fracture of the distal radius is the most common injury to the human skeleton. With developments in its treatment, more is being expected in terms of functional results. The ideal of a standardized approach taking account of different fracture types presupposes the availability of a commonly accepted classification system. The most suitable of classification is the AO classification. A retrospective analysis of 80 fractures of the distal radius that were treated in our hospital from January 1998 through December 1998 revealed good and very good objective results. Subjectively, only a few patients had any problems during follow-up. The results justify varying the surgical therapy by fracture type according to the AO classification. In our clinic percutaneous Kirschner wiring has been successfully used since 1996, particularly in the treatment of A2, A3, B1, B2 and C1 fractures.
    Notes: Die Behandlung der distalen Radiusfraktur als häufigster Fraktur des menschlichen Skeletts stellt zunehmend höhere Ansprüche an das funktionelle Ergebnis. Voraussetzung für ein differenziertes und standardisiertes Herangehen ist eine allgemein akzeptierte Frakturklassifikation. Am besten geeignet ist zurzeit diejenige der AO. Bei der Aufarbeitung von 80 operativ versorgten distalen Radiusfrakturen im Zeitraum vom 1.1.1998–¶31.12.1998 wurden bei den objektiven Bewertungskriterien (röntgenologischer Befund und Funktion) sehr gute und gute Behandlungsergebnisse nachgewiesen. Auch bei den subjektiven Kriterien zeigte der überwiegende Teil der nachuntersuchten Patienten keine oder nur geringe Beschwerden. Diese Ergebnisse unterstreichen die Notwendigkeit und den Sinn einer differenzierten operativen Therapie entsprechend dem Frakturtyp nach der AO-Klassifikation, wobei in unserer Einrichtung die perkutane Kirschner-Draht-Spickung seit 1996 zunehmend in das Behandlungskonzept bei der Versorgung besonders von A2-, A3-, B1-, B2- und C1-Frakturen eingebunden wurde.
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  • 69
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Radiusköpfchenfraktur ; Behandlungsergebnisse ; Mason-Klassifikation ; Radiusköpfchenresektion ; Keywords ; Radial head fracture ; Treatment outcome ; Mason classification ; Radial head resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: There are diverging, and in part controversial, views on the best therapy regimen for radial head fractures, especially of the displaced and comminuted types. Radial head resection has been critically reviewed in recent years. In the periods 1984–1993 and 1996–1999 patients with a total of 105 radial head fractures were treated in the hospital as in-patients, and clinical and radiological follow-up was possible for 74 of these fractures. The fracture types were classified according to Mason’s system. Undisplaced fractures were treated conservatively, displaced 2-fragment fractures by open reduction and screw fixation, and multifragment fractures by a radial head resection. The results have been studied with reference to function and radiological appearance using the „Functional Rating Index“ of Broberg and Morrey and the radiological score of Albrecht and Ganz. After conservative therapy the results were excellent or good in over 80% of cases, satisfactory in 12.5% and poor in 6.3%. After reduction and internal fixation, again 80% had excellent and good results. After radial head resection excellent and good results were achieved in 54.6% of the cases, satisfactory in 24.2%, and poor in 21.2%, but there was a particularly high proportion of patients with severe accompanying injuries affecting the prognosis in this group. With the correct indications and technique, radial head resection is a treatment procedure that can still be recommended and has good overall prospects of success. This is especially true in the case of isolated radial head fracture, in which it yields excellent or good results in approximately 70% of cases.
    Notes: Hinsichtlich des Therapieregimes von Radiusköpfchenfrakturen, insbesondere bei dislozierten Bruchformen und Trümmerfrakturen, bestehen deutlich divergierende, teilweise kontroverse Auffassungen. In den letzten Jahren wurde insbesondere die Radiusköpfchenresektion einer kritischen Betrachtung unterzogen. Von 1984–1993 sowie 1996–1999 wurden in unserer Klinik 105 ¶Radiusköpfchenfrakturen stationär behandelt, von denen 74 klinisch und radiologisch nachuntersucht wurden. Zur Frakturtypbestimmung fand die Klassifikation nach Mason Anwendung. Nichtdislozierte Frakturen wurden konservativ, dislozierte 2-Fragment-Frakturen durch eine offene Reposition und Verschraubung, und Mehrfragmentfrakturen durch eine Radiusköpfchenresektion behandelt. Zur Beurteilung der Ergebnisse wurden der Functional-rating-Index nach Broberg u. Morrey und der radiologische Score nach Albrecht u. Ganz verwendet. Nach konservativer Therapie resultierten 〉 80% ausgezeichnete und gute sowie 12,5% befriedigende und 6,3% schlechte Ergebnisse. Nach Reposition und Osteosynthese waren wiederum 80% ausgezeichnete und gute Resultate zu verzeichnen. Nach Radiusköpfchenresektion wurden in 54,6% der Fälle ausgezeichnete und gute, in 24,2% befriedigende und in 21,2% schlechte Ergebnisse erzielt, wobei in dieser Gruppe der Anteil prognosebeeinflussender, schwerer Begleitverletzungen besonders groß war. Bei entsprechender Indikation und Technik ist die Radiusköpfchenresektion nach wie vor ein empfehlenswertes Behandlungsverfahren mit insgesamt guter Prognose. Das gilt insbesondere für die isolierten Speichenköpfchenbrüche mit etwa 70% ausgezeichneten und guten Ergebnissen.
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  • 70
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    Trauma und Berufskrankheit 2 (2000), S. 341-343 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Tarsaltunnelsyndrom ; Ätiologie ; Trauma ; Diagnose ; Therapie ; Keywords ; Tarsal tunnel syndrome ; Aetiology ; Trauma ; Diagnosis ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In this paper we describe the tarsal tunnel syndrome with reference to our own experience in 10 cases and the literature. Compared with the numerous injuries involving the ankle and foot, the diagnosis of tarsal tunnel syndrome is rare. In the case of a painful foot of unknown aetiology, the differential diagnosis should therefore include tarsal tunnel syndrome. Our presentation discusses the aetiology and pathology of the tarsal tunnel syndrome, and particularly that caused by trauma. We also describe an effective therapeutic approach based on surgical decompression.
    Notes: Anhand der Literatur und eigenen Erfahrungen von 10 Operationen wird das Tarsaltunnelsyndrom dargestellt. Gemessen an der Vielzahl der Traumen im Sprunggelenk- und Fersenbeinbereich wird die Diagnose selten gestellt. Bei unklaren Fußschmerzen sollte daher differenzialdiagnostisch ein Tarsaltunnelsyndrom in Erwägung gezogen werden. Es wird auf die Ätiologie, die Pathologie sowie auf den Zusammenhang zu Traumen eingegangen und die effektive Therapie durch operative Dekompression beschrieben.
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  • 71
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Last tragende Schulter ; Biomechanik ; Rollstuhlantrieb ; Degeneration ; Überlastung ; Keywords ; Weight-bearing shoulder ; Biomechanics ; Wheelchair propulsion ; Degeneration ; Overuse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The shoulder is the most mobile joint in the body. In patients who are short- or long-term wheelchair users, it also takes over the function of an injured or paralysed lower limb. In these patients, the shoulder is therefore prone to overuse resulting in structural damage and pain. Any therapy of the weight-bearing shoulder remains difficult, and knowledge of the anatomical and pathobiomechanical features is therefore mandatory. This article describes the anatomy, biomechanics and pathologic biomechanics of the weight-bearing shoulder and summarises the options for preventive and therapeutic treatment.
    Notes: Die Schulter, als mobilstes aller Gelenke, übernimmt besonders bei Patienten, welche kurz- oder langfristig auf den Rollstuhl angewiesen sind, die Funktion der verletzten oder gelähmten unteren Extremität. Dabei wird die Schulter sehr oft überfordert, sodass Schmerzen und strukturelle Schäden resultieren. Da die Therapie dieser Last tragenden Schulter weiter schwierig bleibt, ist zum Verständnis der Therapie, aber insbesondere auch hinsichtlich der Prävention, ein Wissen über anatomische und pathobiomechanische Zusammenhänge wertvoll. Dieser Artikel gibt einen anatomischen, biomechanischen und pathobiomechanischen Überblick über das Problem „Last tragende Schulter“ und weist auf Therapie- und Präventionsmöglichkeiten hin.
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  • 72
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; B-Bild-Sonographie ; Gelenkfortsatzfrakturen des Unterkiefers ; Keywords ; B-scan ultrasonography ; Fractures of the mandibular condyle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The aim of this study was to analyse the value of B-scan ultrasonography in the diagnosis of mandibular condylar fractures. A total of 39 condylar fractures of the mandible in 32 patients were investigated by means of ¶B-scan ultrasound and standard X-ray projections. In 67% of positive cases ultrasound imaging enabled correct diagnosis of the fracture. Diastasis of fragments, deviations of the axis, and interposition of soft tissues into the fracture line were identified by B-scan ultrasonography. X-ray diagnosis confirmed all fractures. Despite the close topographic relation of the condyle to the covering skin, the imaging of the these fractures by ultrasound was impaired. There are various reasons for this. The first is that the transducer head can be applied to only a limited facial area (small diagnostic window) to image the region of interest. This means that ultrasonographs of the bone surface in two planes are not possible. Secondly, since ultrasound is used for diagnostic reasons at a frequency of 7.5 MHz, imaging of the fracture line is limited to the lateral aspect of fractures, i. e. the bone surface. The course of the fracture lines to the lingual surface was highly variable. In addition, the complete course of the fracture line could not be visualized by ultrasound in cases with a fracture in the sagittal plane. These are the reasons why in the case of condylar fractures of the mandible decisions on therapy cannot safely be made on the basis of ultrasound alone. Ultrasonographic imaging of mandibular condylar fractures is not the diagnostic tool of choice in this entity. It can be applied in patients refusing X-ray diagnosis, but it is mandatory to inform these patients about the limitations of B-scan ultrasonographic diagnosis in mandibular condylar fractures.
    Notes: Ziel dieser Untersuchung war, den Stellenwert der B-Bild-Sonographie im Vergleich zur Röntgendiagnostik für die Diagnostik der Gelenkfortsatzfrakturen des Unterkiefers zu bestimmen. Es wurden 32 Patienten mit ¶39 Frakturen des Gelenkfortsatzes des Unterkiefers B-Bild-sonographisch und konventionell radiologisch untersucht. Die Sonographie hatte mit einer Rate von 67% richtig-positiven Frakturdiagnosen eine nur mäßige diagnostische Treffsicherheit. Insbesondere sind Diastasen, Achsabknickungen und interponierende Weichgewebe in den Frakturspalt sonographisch erkennbar. Radiologisch wurden alle Frakturen nachgewiesen. Trotz der oberflächennahen Lage des Unterkiefergelenkfortsatzes ergaben sich aufgrund der Charakteristik des Sonogramms, nur die laterale Fläche des Gelenkfortsatzes ausschnittsweise darzustellen, der beschränkten Applikationsfläche des Schallkopfs in diesem Bereich mit der Folge fehlender übersichtlicher Darstellung des Knochens in 2 senkrecht zueinander stehenden Ebenen und der in eigenen Untersuchungen limitierten Frequenzauswahl erhebliche Schwierigkeiten in der Interpretation der Befunde (Verlaufskontrolle, Differenzialdiagnose des Kapselrisses, fehlende Identifizierung nicht dislozierter Frakturen). Die Sonographie eignet sich nur sehr eingeschränkt als Untersuchungstechnik für Gelenkfortsatzfrakturen des Unterkiefers, ¶z. B. für Patienten, die eine Röntgenuntersuchung verweigern. In diesen Fällen ist eine Aufklärung über die engen Grenzen der Aufnahmetechnik erforderlich.
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  • 73
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    Trauma und Berufskrankheit 2 (2000), S. 270-276 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Humeruskopf ; 3-Fragment-Fraktur ; 4-Fragment-Fraktur ; Konservative Therapie ; Osteosynthese ; Schulterprothese ; Keywords ; Humeral head ; Comminuted fractures ; Conservative therapy ; Osteosynthesis ; Prosthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Comminuted humeral head fractures require individually tailored treatment, which depends on each patient’s age and bone quality. While osteosynthesis is generally applied in younger people, shoulder prostheses are frequently used in elderly patients with osteoporosis. In addition to surgery, conservative therapy is still of importance. In a retrospective study we report on 50 patients with 51 comminuted proximal humeral fractures, who were treated in our department between 1996 and 1999.
    Notes: Die Therapie der Mehrfragmentfrakturen des proximalen Humerus erfordert ein differenziertes Vorgehen hinsichtlich der zur Verfügung stehenden Behandlungsmethoden. Während für die im Berufsleben stehenden Patienten die osteosynthetische Versorgung häufig angemessen scheint, kommen Schulterprothesen eher bei älteren Patienten mit unzureichender Knochenfestigkeit infolge von Osteoporose zur Anwendung. Aber auch die konservative Behandlung hat bei beiden Altersgruppen durchaus noch einen wichtigen Stellenwert. Es wird über die Behandlungsergebnisse von 50 Patienten mit 51 Mehrfragmentfrakturen des proximalen Humerus, die zwischen 1996 und 1999 in unserer Klinik behandelt worden waren und die im Rahmen einer retrospektiven Studie nachuntersucht wurden, berichtet.
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    Trauma und Berufskrankheit 2 (2000), S. 284-287 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Humerusschaftfraktur ; Radialisparese ; Revisionsindikation ; Keywords ; Humeral shaft fracture ; Radial nerve paresis ; Indication for revision
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In 115 cases of humeral shaft fractures we saw accompanying primary paresis of the radial nerve in 12 (10.4%) cases and secondary paresis of the radial nerve in 2 (1.7%). The secondary pareses occurred postoperatively. The primary lesions to the nerve were caused predominantly by A-type fractures in the distal third of the humerus. In 8 of the ¶12 cases of primary paresis there was completely spontaneous recovery; residual disturbances remained in 4 cases. Among the secondary lesions there was only 1 in which complete recovery was achieved; in 1 the sensitive paresis persisted unchanged. In none of these cases did we perform an operative exposure because of the paresis of the radial nerve. In the recent literature voices recommending immediate operative revision for a humeral shaft fracture with accompanying radial nerve palsy are dominant. Because there would probably be spontaneous remission in a high proportion of cases and also because of the risk that a lesion to the nerve could be caused by the exposure, we advise against early exposure. We recommend that revision is not undertaken immediately in such cases, but rather as an early secondary procedure (4-8 weeks) if no tendency to remission can be observed.
    Notes: In 115 Fällen von Oberarmschaftfrakturen wurden 12 primäre (10,4%) und 2 sekundäre (1,7%) begleitende Funktionsstörungen des N. radialis gesehen. Die sekundären Paresen traten ausschließlich postoperativ auf. Ursache der primären Nervenschädigungen waren überwiegend A-Frakturen im distalen Drittel des Humerus. Komplett spontan erholt hatten sich 8 der 12 primären Paresen, in 4 Fällen blieben Reststörungen zurück. Bei den sekundären Funktionsausfällen kam es 1-mal zur kompletten Rückbildung, 1-mal blieb die sensible Lähmung bestehen. In keinem Fall wurde wegen der Radialisparese eine operative Freilegung vorgenommen. In der neueren Literatur überwiegen die Stimmen, welche bei einer Oberarmschaftfraktur mit begleitender Radialisparese zum sofortigen operativen Revidieren raten. Wegen der nachweislich hohen Rate der Spontanremission und gleichzeitigen Gefahr der Schädigung des Nervs durch seine Freilegung raten wir von einer sofortigen Probefreilegung ab. Wir empfehlen, in diesen Fällen nicht sofort zu revidieren, sondern den operativen Eingriff bei unbefriedigender Erholungstendenz früh sekundär (nach 4-8 Wochen) durchzuführen.
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  • 75
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    Trauma und Berufskrankheit 2 (2000), S. 382-386 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Krankheitsbild der chronischen obstruktiven Bronchitis/Emphysem ; Vollbeweis ; Stichtagsregelung ; Beweislast ; Verhältnis der Berufskrankheiten chronische obstruktive Bronchitis/Emphysem und Silikose ; Keywords ; Clinical picture of chronic obstructive bronchitis/emphysema ; Burden of proof ; Relationship between bronchitis/emphysema and silicosis as occupational illnesses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Chronic obstructive bronchitis/emphysema of miners at the face in hard coal mines has caused the administration department considerable legal and medical problems ever since it was instituted. They are dominated by the application of the suspense date ruling in §6 of the regulations on occupational illnesses, according to which this occupational illness cannot be recognized if the insurance case was initiated after the suspense date, that is to say after the 31.12.1992. Medical documentation of when the insured person started to suffer from chronic obstructive emphysema is frequently hotly disputed among medical expert witnesses. It is not rare for doctors’ estimates to vary by many years. This is connected on the one hand with the particular character of the clinical pictures caused by this illness and on the other with the fact that there is still no definite consensus over what conditions must be fulfilled for absolute documentation. Much to the surprise of the administration, these difficulties have even been known to lead to burden of proof decisions. In addition, opinions vary among medical practitioners about the relationship between chronic obstructive bronchitis/emphysema and silicosis.
    Notes: Die chronische obstruktive Bronchitis bzw. das Emphysem von Bergleuten unter Tage im Steinkohlenbergbau bereitet der Verwaltungspraxis seit ihrer Einführung nicht unerhebliche rechtliche und medizinische Schwierigkeiten. Im Vordergrund steht die Anwendung der Stichtagsregelung in §6 BKV, wonach diese Berufskrankheit nur dann anerkannt werden kann, wenn der Versicherungsfall nach dem Stichtag, also nach dem 31.12.1992, eingetreten ist. Der medizinische Nachweis, wann der Versicherte an der chronischen obstruktiven Bronchitis bzw. dem Emphysem erkrankt ist, ist häufig unter den medizinischen Sachverständigen sehr umstritten. Die Einschätzungen der Mediziner liegen nicht selten viele Jahre auseinander. Dies hängt einerseits mit der Eigenart dieser Krankheitsbilder zusammen und andererseits damit, dass noch kein sicherer Konsens darüber besteht, welche Voraussetzungen an den Vollbeweis zu stellen sind. Diese Schwierigkeiten haben sehr zur Überraschung der Verwaltungspraxis sogar zu Beweislastentscheidungen geführt. Im Übrigen bestehen unterschiedliche medizinische Auffassungen über das Verhältnis der chronischen obstruktiven Bronchitis bzw. dem Emphysem und der Silikose zueinander.
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  • 76
    ISSN: 1432-1335
    Keywords: Key words Blood group antigen ; ABH isoantigens ; Colorectal carcinoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The deletion of blood group ABH isoantigens on tumor tissues has been reported to be an adverse prognostic marker for patients with various solid tumors. In the present study, we evaluated the prognostic value of altered expression of ABH isoantigens in colorectal carcinomas. Using monoclonal antibodies, the expression of A, B, and H antigens was assessed by immunohistochemistry on paraffin-embedded carcinoma samples from 82 patients who had undergone surgery for colorectal cancer. ABH isoantigens were found to be deleted in 36 carcinomas (43.9%) and expressed in 46 (56.1%). Univariate and multivariate analysis using a logistic regression model revealed that N factor (lymph node metastasis) and blood group type were independently related to the expression of ABH isoantigens. In contrast to previous reports on other cancers, patients whose colorectal carcinomas express ABH isoantigens had a poorer prognosis than those whose carcinomas showed deletion of ABH isoantigens (P = 0.0008). The expression of ABH isoantigens was an independent prognostic variable, in addition to T (depth of tumor invasion), N, and M (distant metastasis) factors, as shown by means of Cox regression analysis. In conclusion, the expression of ABH isoantigens in carcinoma tissue is an important poor prognostic factor in patients with colorectal cancer. This variable needs to be considered in the design of future trials of therapy.
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  • 77
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    Journal of cancer research and clinical oncology 126 (2000), S. 280-284 
    ISSN: 1432-1335
    Keywords: Key words Thymoma ; Prognostic factors ; Prognosis ; DNA cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Purpose: The aim of this work was to evaluate the prognostic significance of DNA image cytometry in thymoma. Patients and methods: Image cytometric studies with an automatic video-based analysis system (LEYTAS) were carried out on 47 archival specimens from 36 patients with thymomas who underwent operation at a single institution from 1954 to 1992. The significance of aneuploidy DNA-content (5c-exceeding events), and nuclear size on stage and survival were evaluated. The median follow-up was 52.7 (6–164) months. Results: Masaoka's stage was predictive of aneuploidy (P 〈 0.01) and disease-free survival (P 〈 0.015). In stage I 18% of the tumors were aneuploid, in stage II 78%, in stage III 85% and in stage IV 100%. The occurrence of 5c-exceeding events was associated with both decreased disease-free survival (P 〈 0.01) and overall survival (P = 0.013). Nuclear size was not significantly correlated to stage. Under multivariate analysis, aneuploidy and DNA content failed to attain independent significance for stage, performance status, and histology. Conclusion: DNA image cytometry may provide additional information about the prognosis of resected thymoma.
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  • 78
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    Journal of neurology 247 (2000), S. 943-948 
    ISSN: 1432-1459
    Keywords: Key words Transverse myelitis ; Motor evoked potentials ; Somatosensory evoked potentials ; Electromyography ; Prognosis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A systematic evaluation of anterior horn cell, motor and sensory pathways is possible by electromyography (EMG), motor (MEPs) and somatosensory (SEPs) evoked potentials, respectively, which may provide valuable information on acute transverse myelitis (ATM). In a prospective hospital-based study, EMG, MEP and SEP studies were carried out on admission and after 3 months in 39 patients with ATM. All the patients also underwent detailed clinical evaluation, and spinal magnetic resonance imaging (MRI) was performed in 28. Outcome was defined at the end of 3 months as poor, partial or complete recovery on the basis of functional status. Spinal MRI revealed hyperintense signal changes in T2 extending for two segments to the entire spinal cord. Central motor conduction time to tibialis anterior (CMCT-TA) was more frequently abnormal (90%), followed by tibial SEP (77%). CMCT to abductor digiti minimi (ADM) was abnormal in 30% and median SEP in 15% of patients. Evidence of denervation on EMG was present in 51% of patients. The CMCT-TA improved in 48% patients and tibial SEP in 32%. Median SEP improved in all patients, and CMCT-ADM remained prolonged in two. At 3 months 2 patients had died, and 18 had poor, 10 partial and 9 complete recovery. CMCT was correlated with miscle power, tone, reflec and MRI changes. Patients' outcome of was correlated with CMCT, SEP and EMG. These results are consistent with pronounced involvement of dorsal region of spinal cord in ATM. MEP is more frequently abnormal than SEP.
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  • 79
    ISSN: 1432-1459
    Keywords: Key words Sarcoidosis ; Spinal cord ; Magnetic resonance imaging ; Corticosteroid therapy ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spinal cord sarcoidosis is a rare disorder whose natural history and therapeutic outcome are not fully known. We examined four patients with spinal cord sarcoidosis both clinically and radiologically, particularly in relation to corticosteroid treatment. The initial manifestation was cervical myelopathy in three and uveitis in one. All four patients progressed slowly until corticosteroid therapy was initiated. The cervial spine was involved in all patients. Magnetic resonance imaging (MRI) showed spinal cord swelling with T2-weighted high intensity and linear leptomeningeal and patchy or diffuse intramedullary enhancement with gadolinium diethylene triaminepentaacetic acid. With corticosteroid therapy, dramatic improvement was seen on MRI, including disappearance or marked reduction of swelling and enhancement. Plasma levels of angiotensin-converting enzyme (ACE) were also markedly improved. In contrast, the clinical symptoms were little improved in one patient, unchanged in two, and rather worsened in one patient. Recurrence was seen on MRI at the maintenance dose in all four patients, without any dramatic change in clinical manifestation. MRI findings and plasma ACE are well correlated with active leasion of the spinal cord sarcoidosis, providing a useful marker for recurrence, but do not parallel the clinical manifestations.
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  • 80
    ISSN: 1432-1238
    Keywords: Key words Mortality ; Oliguria ; Multiple organ failure ; Severity-of-illness ; Prognosis ; Scoring systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To describe risk factors for the development of acute renal failure (ARF) in a population of intensive care unit (ICU) patients, and the association of ARF with multiple organ failure (MOF) and outcome using the sequential organ failure assessment (SOFA) score. Design: Prospective, multicenter, observational cohort analysis. Setting: Forty ICUs in 16 countries. Patients: All patients admitted to one of the participating ICUs in May 1995, except those who stayed in the ICU for less than 48 h after uncomplicated surgery, were included. After the exclusion of 38 patients with a history of chronic renal failure requiring renal replacement therapy, a total of 1411 patients were studied. Measurements and results: Of the patients, 348 (24.7 %) developed ARF, as diagnosed by a serum creatinine of 300 μmol/l (3.5 mg/dl) or more and/or a urine output of less than 500 ml/day. The most important risk factors for the development of ARF present on admission were acute circulatory or respiratory failure; age more than 65 years, presence of infection, past history of chronic heart failure (CHF), lymphoma or leukemia, or cirrhosis. ARF patients developed MOF earlier than non-ARF patients (median 24 vs 48 h after ICU admission, p 〈 0.05). ARF patients older than 65 years with a past history of CHF or with any organ failure on admission were most likely to develop MOF. ICU mortality was 3 times higher in ARF than in other patients (42.8 % vs 14.0 %, p 〈 0.01). Oliguric ARF was an independent risk factor for overall mortality as determined by a multivariate regression analysis (OR = 1.59 [CI 95 %: 1.23–2.06], p 〈 0.01). Infection increased the risk of death associated with all factors. Factors that increased the ICU mortality of ARF patients were a past history of hematologic malignancy, age more than 65 years, the number of failing organs on admission and the presence of acute cardiovascular failure. Conclusion: In ICU patients, the most important risk factors for ARF or mortality from ARF are often present on admission. During the ICU stay, other organ failures (especially cardiovascular) are important risk factors. Oliguric ARF was an independent risk factor for ICU mortality, and infection increased the contribution to mortality by other factors. The severity of circulatory shock was the most important factor influencing outcome in ARF patients.
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  • 81
    ISSN: 1432-1238
    Keywords: Key words Cardiopulmonary bypass ; Coronary artery bypass graft ; Valve surgery ; Thoracic aortic surgery ; Prognosis ; Hypotension ; Systemic inflammatory response syndrome (SIRS) ; Procalcitonin ; Endotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To investigate procalcitonin (PCT) levels in patients undergoing cardiopulmonary bypass (CPB) in order to assess the prevalence and prognostic capacity of elevated PCT levels following CPB in open heart surgery.¶Design: prospective observational study in consecutive patients.¶Setting: Twenty-four-bed ICU, department of thoracic and cardiovascular surgery, university hospital.¶Patients: Seven hundred and twenty two patients, 691 of whom underwent CPB, i. e., 476 had coronary bypass surgery (CABG), 130 valve replacement, 34 combined CABG and valve replacement, and 23 thoracic aortic surgery.¶Interventions: Standard perfusion techniques were used with cardioplegic arrest and mild hypothermia (28–32 °C). With the exception of thoracic aortic procedures, full–flow perfusion was performed.¶Measurements and results: PCT was measured prior to surgery and daily thereafter until ICU discharge or death. PCT significantly increased at day 1 postoperatively compared to baseline values (0.25 ± 1.65 vs 6.49 ± 22.0 ng/ml, p 〈 0.005). However, in 55.1 % of patients PCT was below 1.0 ng/ml. In 12.8 % of CABG patients PCT was increased to 〉 5.0 ng/ml, compared to 39 % in valve patients and 35 % of patients with aortic surgery. An elevated PCT level 〉 1.0–5.0 ng/ml at day 1 was highly predictive of mortality (P 〈 0.03, vs 〈 1.0 ng/ml), with an additional accuracy when levels 〉 5.0 ng/ml were measured (P 〈 0.002 vs 〈 1.0 ng/ml).¶Conclusions: These results provide evidence that PCT might serve as an early prognostic marker in patients undergoing CPB in open heart surgery. It may be worth considering immunomodulating approaches in patients presenting elevated PCT levels in the early phase after CPB.
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  • 82
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    Trauma und Berufskrankheit 2 (2000), S. 11-18 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Beckenfraktur ; Epidemiologie ; Diagnostik ; Klassifikation ; Keywords ; Pelvic fracture ; Epidemiology ; Diagnosis ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Pelvic fractures, except for those of the acetabulum, account for 0.3–8% of all fractures and can be considered rare. They are generally either stable, and result from “low-energy” trauma, or unstable, mostly following “high-energy” trauma. The latter are associated with an increased morbidity, mortality and invalidity. Correct and complete ¶diagnosis including accompanying injuries may be difficult owing to the complex anatomical and biomechanical relations, ¶but is essential, particularly in the case of complex fractures and injury patterns, for immediate and adequate therapeutic management of fractures and of the frequently severe accompanying injuries. Classification of these fractures based on detailed X-ray evaluation not only allows for approximative estimation of injury severity and prognosis and is helpful in the selection of therapeutic procedures, but also facilitates comparative evaluations of different fracture types or treatment concepts. The conceptional aim of this paper is not a scientifically oriented presentation of details, but an overview relevant to clinical practice and to the work of experts commissioned to prepare official reports on the epidemiology, pathomechanisms, diagnosis and classification of pelvic fractures.
    Notes: Beckenfrakturen, ausgenommen Azetabulumfrakturen, sind mit einem Anteil am Gesamtkollektiv der Frakturen von 0,3–8% selten. Im Allgemeinen sind sie entweder stabil und Folge eines Low-energy-Traumas oder instabil, meist in Folge eines High-energy-Traumas. Letztere sind mit einer deutlich erhöhten Morbidität, Mortalität bzw. Invalidität vergesellschaftet. Die korrekte und vollständige Diagnose einschließlich Begleitverletzungen kann aufgrund der komplexen anatomischen und biomechanischen Zusammenhänge schwierig sein. Insbesondere bei komplexen Fraktur- und Verletzungsmustern ist sie jedoch die Voraussetzung für ein rasches und adäquates Therapiemanagement der Fraktur und der teils vitalen Begleitverletzungen. Die Frakturklassifikation auf der Basis einer exakten Röntgendiagnostik ermöglicht nicht nur eine approximative Schweregrad- und Prognoseabschätzung bzw. Hinweise für das therapeutische Verfahren, sondern letztlich auch eine vergleichende Evaluation verschiedener Frakturtypen bzw. Behandlungskonzepte. Konzeptionelles Ziel dieses Beitrags ist nicht die wissenschaftlich orientierte Darstellung von Detailfragen, sondern ein für die klinische Praxis und gutachterliche Tätigkeit relevanter Überblick zu Epidemiologie, Unfallmechanismus, Diagnostik und Klassifikation von Beckenfrakturen.
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    Trauma und Berufskrankheit 2 (2000), S. 39-45 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Beckenringfrakturen ; Klassifikation ; Behandlungsverfahren ; Komplikationen ; Ergebnisse ; Keywords ; Pelvic ring fractures ; Classification ; Treatment ; Complications ; Results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Injuries of the pelvis are caused by high-energy trauma, and concomitant injuries are therefore often found. Many patients with such pelvic injuries have multiple injuries. Accurate diagnosis and classification are both fundamental to adequate therapy. Especially in the presence of complex pelvic trauma and in polytraumatised patients priority-oriented and fast procedures are essential. Type B and C instabilities require operative treatment. In emergency cases with unstable pelvic fractures external fixation has proved successful. For definitive treatment with internal stabilisation different internal fixation procedures with screws and plates selected with reference to the features of the injury are needed. The operative stabilisation of the pelvic ring demands particular care, because various main vessels and nerves are adjacent to the injury site. Ultimately, the results of treatment depend heavily on the quality of anatomical restoration of the pelvic ring.
    Notes: Beckenverletzungen entstehen aufgrund hoher lokaler Gewalteinwirkung und sind deswegen häufig mit Begleitverletzungen kombiniert. Bei vielen beckenverletzten Patienten liegt ein Polytrauma vor. Grundlage einer adäquaten Therapie von Verletzungen des Beckenrings sind eine exakte Diagnostik und Klassifikation. Vor allem beim komplexen Beckentrauma und beim Vorliegen eines Polytraumas ist ein rasches und an Prioritäten orientiertes Vorgehen entscheidend. Instabilitäten vom Typ B und C erfordern eine operative Stabilisierung. Dabei steht in der Notfallbehandlung des instabilen Beckenrings die externe Stabilisierung im Vordergrund. Beim Übergang auf interne Fixationsverfahren haben sich abhängig von der Verletzungsmorphologie verschiedene Schrauben- und Plattenmontagen bewährt. Die operative Stabilisierung des Beckenrings erfordert wegen der engen Nachbarschaft zu verschiedenen Gefäß- und Nervenbahnen besondere Sorgfalt. Das Endergebnis hängt dabei ganz wesentlich davon ab, wie gut die Wiederherstellung der anatomischen Form des Beckenrings gelungen ist.
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  • 84
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    Trauma und Berufskrankheit 2 (2000), S. 69-77 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Nagelung ; Aufgebohrt ; Unaufgebohrt ; Knochenheilung ; Keywords ; Nailing ; Reamed ; Unreamed ; New bone formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: A comparative investigation of differences in new bone formation and cortical remodelling after reamed and unreamed nailing was carried out in a standardized animal model. An oblique osteotomy of the tibia was created in 19 sheep, followed by intramedullary nailing. The medullary cavity was reamed ¶in 10 of the animals, while in 9 sheep unreamed nailing was performed. After an observation period of 10 weeks, microradiographical assessment indicated more intensive bone regeneration and better bridging of the osteotomy in the animals with unreamed nailing. In addition, fewer aseptic bone sequestra were identified in the “unreamed” group. Morphometric measurements of the specimens by fluorescence ¶microscopy showed a significantly earlier and more pronounced interfragmentary and periosteal regeneration of bone, and significantly smaller central cortical zones without any remodelling. The results are of particular clinical relevance to the stabilization of fractures with severe open or closed soft tissue injury. Unreamed nailing procedures do less damage to the bone than reamed procedures. The former are less invasive and lead to earlier and more intensive bone regeneration. Not only these biological advantages, but also the lower mechanical stability and strength associated with unreamed nailing should be taken into account when assessing whether reamed or unreamed nailing is indicated.
    Notes: An einem standardisierten Tiermodell wurde nach unaufgebohrter vs. aufgebohrter Marknagelung vergleichend untersucht, ob Unterschiede in der Knochenneubildung und dem Ausmaß der kortikalen Nekrose zu finden sind. Bei 19 Schafen erfolgte eine quere Tibiaosteotomie mit nachfolgender Verriegelungsmarknagelung. In 10 Fällen wurde die Markhöhle aufgebohrt, 9-mal kam die unaufgebohrte Nagelung zum Einsatz. Nach 10-wöchiger Beobachtungszeit fanden sich mikroradiographisch bei unaufgebohrter Nagelung eine größere Knochenneubildung und eine bessere Überbrückung der Osteotomie. In der unaufgebohrten Gruppe waren weniger aseptische Knochensequester zu erkennen. Morphometrische Messungen der Präparate mit der Fluoreszenzmikroskopie zeigten nach unaufgebohrter Marknagelung eine signifikant frühzeitigere und ausgeprägtere interfragmentäre bzw. periostale Knochenneubildung sowie signifikant kleinere zentrale Kortikalisnekrosen. Die Ergebnisse haben besondere klinische Relevanz für die Stabilisierung von Frakturen mit schwerem offenem oder geschlossenem Weichteilschaden. Die unaufgebohrte Marknagelung ist weniger invasiv und schädigt den Knochen geringer als die aufgebohrte Nagelung. Sie führt zu einer intensiveren und frühzeitigeren Knochenneubildung. Diese biologischen Vorteile, aber auch die geringere mechanische Stabilität und Festigkeit nach unaufgebohrter Marknagelung sollten bei der Indikation zur unaufgebohrten oder aufgebohrten Verriegelungsnagelung Berücksichtigung finden.
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  • 85
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    Trauma und Berufskrankheit 2 (2000), S. 130-131 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Arbeitsunfall ; Gesetzliche Aspekte ; Medizinische Aspekte ; Kosten ; Keywords ; Work injury ; Legal aspects ; Medical ¶aspects ; Costs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: European and North American developments in prevention, rehabilitation and ¶compensation are briefly reviewed
    Notes: Es wird eine kurze Übersicht über die auf dem „4th International Congress on Medical-Legal Aspects of Work Injuries“ in Toronto, Kanada, vom 6. bis 9.6.1999, angesprochenen Themen – europäische und nordamerikanische Entwicklungen in Prävention, Rehabilitation und Entschädigung – gegeben.
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  • 86
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    Trauma und Berufskrankheit 2 (2000), S. 111-117 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Polytrauma ; Marknagelung ; Verfahrenswechsel ; Bohrtechnik ; Solider Nagel ; Keywords ; Polytrauma ; Intramedullary nailing ; Exchange treatment ; Reaming technique ; Solid nail
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: As fractures of the long bones cause a substantial additive systemic stress by way of pain, blood loss and release of mediators, and instability of the extremities means that the intensive treatment that polytraumatized patients need can be delayed for a long time, the necessity for primary stabilization of long bones in severely injured patients is now generally accepted. After decades of discussion and research, however, there are still wide differences of opinion on which fixation technique is best in the acute phase. When polytraumatized patients are considered to decide whether primary medullary nailing is indicated logistic aspects should be taken into account as well as information derived from scientific investigations: The techniques making use of unreamed nails are challenging to the surgeon, which means that if conditions are not completely favourable in terms of staff, time of day and equipment it is certainly possible for a suboptimal outcome to be obtained with a substantially greater investment of time than normal. Thus, there are also logistic reasons why, in the presence of certain injury patterns and from a certain level of severity of the injuries onward, the advantages and disadvantages of primary stabilization by medullary nailing techniques should be carefully weighed against each other. In these circumstances primary stabilization with an external fixator can have obvious advantages for the patient, as it is so uncomplicated and quick to apply. A lesser additive trauma from the operation in the initial phase when the patient is so vulnerable, plus the shorter operating times and the lower requirement for blood substitutes can have decisive advantages in synergy with the earlier start of medical intensive care. In the secondary surgical phase (more than 4 days after the trauma) it is then generally possible to convert to intramedullary nailing, which gives a superior biomechanical result, in a single operative session. If primary intramedullary nailing is attempted, the possibility of additional stress should be borne in mind; this can be caused, for example, by the use of blunt drills or the high pressure that can develop when solid nails are driven into narrow lumina in the case of simple fractures. An otherwise healthy person with undamaged lungs can compensate for the ¶resulting fat and particle emboli. In the ¶case of a multiply injured patient who is already in a badly weakened state with defence systems strained to the limit, however, such iatrogenic stresses can lead to ¶irreversible damage and even to a lethal ¶outcome.
    Notes: Da Frakturen langer Röhrenknochen eine wesentliche additive Systembelastung durch Schmerzen, Blutverlust und Mediatorenfreisetzung bewirken und instabile Verhältnisse im Bereich der Extremitäten die ordnungsgemäße Intensivbehandlung polytraumatisierter Patienten nachhaltig behindern, besteht heute über die Notwendigkeit der Primärstabilisierung langer Röhrenknochen bei schwer verletzten Patienten weitgehend Einigkeit. Doch auch nach jahrzehntelanger Diskussion und Forschung gehen die Meinungen über das optimale Fixationsverfahren in der Akutphase weit auseinander. Bei der Indikationsstellung zur primären Marknagelung bei Polytraumatisierten sind neben Erkenntnissen aus wissenschaftlichen Untersuchungen auch logistische Erwägungen zu berücksichtigen: Gerade die ungebohrten Techniken sind anspruchsvoll, weswegen unter ungünstigen Bedingungen bezüglich Personal, Tageszeit und Equipment durchaus suboptimale Ergebnisse unter erheblich erhöhtem Zeitaufwand resultieren können. Daher sind bei bestimmten Verletzungsmustern und ab einer gewissen Verletzungsschwere auch aus logistischen Gründen Vor- und Nachteil der primären Stabilisierung durch Marknageltechniken abzuwägen. Hier kann ggf. die primäre Stabilisierung mittels Fixateur externe in Folge der unkomplizierten und raschen Anwendung dem Patienten deutliche Vorteile bringen: Ein geringeres additives operatives Trauma in der initialen vulnerablen Phase sowie kürzere Operationszeiten und ein geringerer Bedarf an Blutersatzstoffen können synergistisch mit der früher einsetzenden intensivmedizinischen Weiterversorgung entscheidende Vorteile bringen. In der sekundären Operationsphase (nach dem 4. posttraumatischen Tag) kann dann in der Regel einzeitig auf die biomechanisch überlegene Marknagelung umgestiegen werden. Wird die primäre Marknagelung angestrebt, sind die Aspekte einer zusätzlichen Belastung zu berücksichtigen, wie z. B. extreme Markraumbohrungen, die Verwendung stumpfer Bohrer oder die hohe Druckentwicklung beim Eintreiben solider Marknägel in dünnlumige Markhöhlen bei einfachen Frakturtypen. Der ansonsten gesunde Mensch mit einer unverletzten Lunge kann die resultierenden Fett- und Partikelembolisationen noch kompensieren. Für den entsprechend vorbelasteten Polytraumatisierten, dessen Defensivsysteme bereits bis an die Kompensationsgrenze belastet sind, können diese iatrogenen Belastungen jedoch zu irreversiblen Schädigungen bis hin zu einem letalen Ausgang führen.
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    Trauma und Berufskrankheit 2 (2000), S. 101-110 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Verfahrenswechsel ; Fixateur externe ; Marknagelung ; Keywords ; Conversion procedure ; External fixator ; Intramedullary nailing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Femoral and tibial shaft fractures can be treated successfully with intramedullary nailing. Locking techniques have made it possible to extend the indications to include comminuted fractures of the proximal and distal thirds. The range of indications for unreamed nailing is becoming increasingly wide. There are, however, restrictions on nailing procedures in polytraumatized patients and in the presence of multiple ipsilateral fractures with or without joint involvement and of fractures with severe soft tissue injury (open or closed). Primary stabilization with the external fixator has proved best for such injuries. Whereas the main difficulties and risks involved in primary intramedullary nailing arise during the initial treatment, complications with the external fixator occur later in the treatment programme. A conversion procedure from the external fixator to intramedullary nailing can combine the advantages of both techniques. For a long time, only studies with fewer than 50 patients were available in the literature. The conversion procedures were not standardized, and the timing of secondary intervention was somewhat arbitrary and/or late, i.e. after 3 weeks or more. Nonetheless, there has been some controversy over the advantages and disadvantages, and also the risks, of a conversion procedure. In our own prospective studies from 1989–1992 and 1993–1994, open and closed second- and third-degree femoral and tibial fractures were first stabilized with an external fixator and then treated by conversion to nail fixation as early as possible and according to strict criteria. Initially medullary nails with slight reaming were used, and in the second phase unreamed nailing was used in all cases. A first prospective study conducted from 1989 to 1992, which included 164 conversion procedures in tibial and 98 in femoral fractures, was carried out according to strict principles: nailing was to be performed as early as possible and under standardized, favorable conditions; the same principles were then followed in all later studies. The results were no worse than those of primary internal fixation in terms of function and time to healing. The infection rate for the conversion procedure was 1.9% overall (femur 2%, tibia 1.8%), which is not significantly different from that for primary nailing. The second study with conversion to unreamed and solid nailing only (tibia 102, femur 31) showed a tendency to a lower infection rate, 0.8% (tibia 1%, femur 0/31); the difference did not reach statistical significance as the number of cases was small and for other reasons. These results, further personal experience, and new publications permit the conclusion that a conversion procedure from primary osteosynthesis with an external fixator to intramedullary nailing as a secondary, definitive osteosynthesis is an appropriate course of action in certain circumstances (e.g. fractures with soft tissue damage whether open or closed, polytrauma).
    Notes: Femur- und Tibiaschaftfrakturen können mit der Marknagelosteosynthese erfolgreich behandelt werden. Durch die Technik der Verriegelung konnte die Indikation auf Frakturen im proximalen und distalen Drittel sowieTrümmerfrakturen erweitert werden. Einen breiten zunehmenden Raum nimmt die unaufgebohrte Marknagelung ein. Grenzen für die Marknagelung sind allerdings bei polytraumatisierten Patienten, Kettenfrakturen mit oder ohne Gelenkbeteiligung und bei Frakturen mit schwerem Weichteilschaden (offen oder geschlossen) gegeben. Bei diesen Verletzungen hat sich die Primärversorgung mit Fixateur externe bewährt. Während sich die Hauptprobleme und Risiken bei der primären Marknagelosteosynthese bei der Erstversorgung stellen, treten Komplikationen mit dem Fixateur externe v. a. im Rahmen der Weiter- und Ausbehandlung auf. Ein Verfahrenswechsel vom Fixateur externe zur Marknagelosteosynthese kann die Vorteile beider Verfahren vereinigen. In der Literatur fanden sich lange Zeit nur kleinere Studien mit Fallzahlen 〈 50 Patienten. Der Verfahrenswechsel war dabei nicht standardisiert, und die Zeitpunkte für denselben waren eher willkürlich und/oder spät, d. h. nach ¶3 und mehr Wochen gesetzt. Die Vor- und Nachteile sowie die Risiken des Verfahrenswechsels wurden trotzdem kontrovers diskutiert. In einer eigenen prospektiven Studie von 1989–1991 wurden geschlossene und offene Femur- und Tibiafrakturen jeweils II. und III. Grads zunächst mit Fixateur externe versorgt und dann zum frühestmöglichen Zeitpunkt unter strengen Kriterien einem Verfahrenswechsel zur Marknagelosteosynthese unterworfen. Anfangs wurde die Marknageltechnik mit geringem Aufbohren, in der 2. Phase durchweg die unaufgebohrte Marknagelung eingesetzt. Diese Studie mit 164 Verfahrenswechseln bei Tibia- und 98 Verfahrenswechsel bei Femurfrakturen wurde ebenso wie später folgende Studien unter strengen Kriterien durchgeführt, nämlich möglichst früh unter standardisierten günstigen Bedingungen zu nageln. Die Ergebnisse zeigten bezüglich Funktion und Ausheilungszeit keinen Nachteil gegenüber primären Osteosynthesen. Die Infektionsrate für den Verfahrenswechsel selbst war von der primären Marknagelung nicht signifikant unterschiedlich. Die Studie mit Verfahrenswechsel zur unaufgebohrten Marknagelung (Tibia n = 102, Femur n = 31) zeigte tendenziell eine (nicht signifikante) Reduktion der Infektrate. Unsere Ergebnisse, die auf diese Studie folgende weitere eigene ¶positive Erfahrung und neuere Publikationen lassen heute den Schluss zu, dass der Verfahrenswechsel für bestimmte Indikationen (Frakturen mit Weichteilschaden –¶offen oder geschlossen – Polytrauma u. a.) ein geeignetes Therapiekonzept ist.
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  • 88
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    Trauma und Berufskrankheit 2 (2000), S. 162-166 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Thorakolumbale Frakturen ; Transpedikuläre Spondylodese ; Spongiosaplastik ; Komplikationen ; Keywords ; Thoracolumbar fractures ; Transpedicular spondylodesis ; Bone grafting ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Spinal fractures are located predominantly at the thoracolumbar junction. After conservative treatment, for unstable fractures operative procedures were established during the last 20 years. Using implants with angular stability, dorsal transpedicular fixation yields good clinical results even compared with those of combined dorsoventral procedures. Transpedicular bone grafting is controversial as resorption frequently occurs; it has given disappointing results in fracture types in which definitive segmental fusion is unavoidable, so that combined dorso-ventral stabilization is necessary in such cases. The most frequent complications of dorsal instrumentation are the result of badly positioned transpedicular screws.
    Notes: Die Verletzungen des thorakolumbalen Übergangs stellen die Mehrzahl der Frakturen der Wirbelsäule dar. Nach der konservativen Therapie hat sich in den letzten beiden Jahrzehnten die operative Versorgung instabiler Frakturen etabliert. Die dorsale transpedikuläre Spondylodese unter Verwendung winkelstabiler Implantate stellt ein Verfahren dar, mit dem sich auch im Vergleich zu aufwändigen dorsoventralen Rekonstruktionen bei den meisten Frakturen gute klinische Resultate erzielen lassen. Der additionellen transpedikulären intrakorporalen Spongiosaplastik wird aufgrund der zu beobachtenden Resorption des Transplantats zunehmend geringere Bedeutung beigemessen. Auch bei Frakturtypen, bei denen eine definitive Fusion angestrebt werden sollte, hat die transpedikuläre interkorporale Knochentransplantation enttäuscht, sodass in derartigen Fällen nach primärer dorsaler Stabilisierung sekundär die Fusion von ventral erfolgen sollte. Die häufigsten Komplikationen bei der dorsalen transpedikulären Spondylodese sind auf Fehllagen der transpedikulären Schrauben zurückzuführen.
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  • 89
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Stumpfes Abdominaltrauma ; Diagnostik ; Sonographie ; Verlaufskontrolle ; Übersehene Verletzungen ; Keywords ; Blunt abdominal trauma ; Diagnosis ; Ultrasound ; Re-examination ; Missed injuries
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Intraabdominal organ lesions after blunt abdominal trauma often are missed, especially in patients with multiple trauma. Missed abdominal injuries have a high rate of morbidity and mortality. Surgical treatment is often successful with a low rate of complications when the case of correct diagnosis is promptly made, which means this is especially tragic, particularly in younger patients. During the past decade abdominal ultrasound has become the primary screening technique of choice for blunt abdominal trauma. With standard views free fluid volumes, as an indirect sign of organic lesions, can be detected in matter of minutes with a high sensitivity of up to 99%. It is reported in the literature that about 10% of abdominal injuries are discovered only on re-examinations carried out because of secondary lesions; our own experience in over 1000 trauma patients was similar. Therefore, repeated examinations are mandatory in all cases to avoid misdiagnosis and delayed therapy. Our own results with a standardized time schedule of ultrasound examinations and different case reports are used to illustrate the typical difficulties in diagnosis following blunt abdominal trauma.
    Notes: Intraabdominale Organläsionen im Rahmen eines stumpfen Bauchtraumas gehören zu den am häufigsten initial übersehenen Verletzungen, insbesondere beim polytraumatisierten Patienten. Dies ist besonders tragisch, da diese Verletzungen bei rechtzeitiger Diagnosestellung und chirurgischer Intervention meist folgenlos zu beherrschen sind, ein Nichterkennen jedoch mit einer hohen Morbiditäts- und Mortalitätsrate verbunden ist. Im vergangenen Jahrzehnt hat sich die Sonographie als Screeningmethode für intraabdominale Verletzungen etabliert. Durch standardisierte Schnittebenen gelingt der Nachweis freier intraabdominaler Flüssigkeit als indirektes Zeichen für eine Organverletzung auch weniger erfahrenen Untersuchern mit einer Sensitivität von bis zu 99% bei sehr kurzen Untersuchungszeiten. Nach den Angaben in der Literatur und eigenen Erfahrungen bei 〉1000 Traumapatienten werden infolge von zweizeitigen Verletzungsformen etwa 10% der Verletzungen erst im Rahmen von Verlaufskontrollen erkannt, welche somit obligatorischer Bestandteil der Basisdiagnostik sein müssen. Anhand eigener Ergebnisse und verschiedener Fallbeispiele wird die Problematik der Diagnostik beim stumpfen Bauchtrauma unter besonderer Berücksichtigung von sonographischen Verlaufskontrollen demonstriert.
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  • 90
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    Trauma und Berufskrankheit 2 (2000), S. 201-210 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Hauterkrankungen ; Hautarztverfahren ; Beratungsarztverfahren ; Hautschutzmaßnahmen ; Gefahrenabwehr ; Rehabilitation ; §3 BKV ; Erstattungsansprüche ; Keywords ; Dermatoses ; Dermatologists’ procedures ; Consultants’ procedures ; Skin protection ; Risk avoidance ; Rehabilitation ; §3 of the ¶Ordinance on Occupational Illnesses ; Entitlement to reimbursement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Precisely in the case of skin diseases it is particularly important to be informed about an occupational illness as early as possible, because seemingly innocuous initial findings can quickly develop into severe findings that remain with the patient throughout the rest of his or her life if no rehabilitation is carried out. The procedure applied by the dermatologist, complemented by the consultant’s procedure, is designed to support this function of early ascertainment and regulation for the accident insurance underwriter. The rehabilitation of insurance holders with skin diseases should initially entail intensive dermatological treatments aimed at a cure, together with consistent application of skin protection. In-patient treatments in selected climatic conditions are a further option. Occupational benefits for rehabilitation are necessary when there is no question, or no longer any question, of risk avoidance, so that from the health aspect it is no longer possible to take responsibility for advising the patient to stay at the workplace occupied so far. It is immaterial both for medical and for occupational benefits aimed at rehabilitation whether the insurance holder’s entitlement is based on §3 of the Ordinance on Occupational Illnesses or whether the insured event of an occupational illness is recognized. As mentioned above, however, this question can be important in the processing of the reimbursement entitlements between the social insurance institutions involved.
    Notes: Gerade bei Hauterkrankungen ist es besonders wichtig, zum frühestmöglichen Zeitpunkt über eine beruflich verursachte Erkrankung unterrichtet zu werden, weil sich aus harmlosen Anfangsbefunden bei versäumten Rehabilitationsmaßnahmen rasch schwerwiegende, oft zeitlebens bestehende Befunde entwickeln können. Das Hautarztverfahren, ergänzt um das Beratungsarztverfahren, soll diese frühzeitige Erfassungs- und Steuerungsfunktion für die Unfallversicherungsträger unterstützen. Die Rehabilitation von hautkranken Versicherten ist zunächst durch intensive Maßnahmen der dermatologischen Heilbehandlung unter Einübung von konsequenten Hautschutzmaßnahmen durchzuführen. Stationäre Heilbehandlungsmaßnahmen unter besonderen klimatischen Bedingungen ergänzen das Angebot. Berufsfördernde Leistungen zur Rehabilitation sind dann notwendig, wenn Maßnahmen der Gefahrenabwehr nicht oder nicht mehr in Betracht kommen, sodass ein Verbleib am bisherigen Arbeitsplatz gesundheitlich nicht zu verantworten ist. Sowohl bei medizinischen als auch bei berufsfördernden Leistungen zur Rehabilitation macht es keinen Unterschied, ob §3 BKV Grundlage des Leistungsanspruchs des Versicherten ist oder ob der Versicherungsfall der Berufskrankheit anerkannt worden ist. Diese Frage kann aber – wie oben schon erwähnt – für die Abwicklung von Erstattungsansprüchen zwischen den Sozialversicherungsträgern Bedeutung haben.
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  • 91
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    Trauma und Berufskrankheit 2 (2000), S. 277-283 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Humerusschaftfraktur ; Intramedulläre Marknagelosteosynthese ; UHN ; Komplikationen ; Behandlungsergebnisse ; Keywords ; Fracture of the humeral diaphysis ; Humerus nail ; UHN ; Complications ; Results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In a retrospective study, 115 fractures of the humeral diaphysis were evaluated, and 94 of the patients were treated by surgical operations. In 64 patients we used an unreamed humerus nail (UHN) to stabilize the fractures of the humerus diaphysis. All patients with an UHN were followed up. Having analysed the system-specific and general complications and the functional, subjective and radiological results we can recommend the UHN for the treatment of both fractures and pseudarthrosis of the humeral diaphysis.
    Notes: In einer retrospektiv durchgeführten Studie wurden 115 Humerusschaftfrakturen ausgewertet. Operativ wurden 94 Patienten, davon 64 mit einem unaufgebohrten Humerusnagel (UHN), versorgt. Die mit einem UHN behandelten Patienten wurden nachuntersucht. Nach Auswertung der systemspezifischen und allgemeinen Komplikationen sowie der funktionellen, subjektiven und radiologischen Ergebnisse kann der UHN sowohl zur Behandlung der frischen Humerusschaftfraktur als auch zur Versorgung von Humerusschaftpseudarthrosen empfohlen werden.
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  • 92
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    Trauma und Berufskrankheit 2 (2000), S. 344-351 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Traumatische Herzschädigung ; Contusio cordis ; Kardiale Diagnostik ; Traumatisches Aortenaneurysma ; Echokardiographie ; Keywords ; Cardiac injury ; Cardiac concussion ; Contusio cordis ; Traumatic aortic aneurysm ; Diagnostic procedures ; Echocardiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The frequency of cardiac injury following chest trauma is often underestimated. The spectrum ranges from asymptomatic cardiac contusion or cardiac concussion reflected only later in alteration of the heart rhythm to the immediately fatal situation of cardiac rupture. The penetrating injuries caused by a variety of objects (e. g. bullets, knives, fractured ribs) are rarely overlooked; the most common mechanisms leading to blunt cardiac injury include rapid rotation of the heart while the great vessels remain fixed, transfer of hydraulic pressure from the abdomen, and direct myocardial compression. All anatomic structures of the heart and great vessels (pericardium, myocardium, valves, coronary arteries and aorta) can be involved, damage to one of these structures often being followed by typical clinical signs leading to different complications. Of the established diagnostic methods (e.g. ECG, investigation for elevated heart enzymes, X-ray) transthoracic and transesophageal echocardiography are the most useful because of their wide availability and mobility. Ultrasonography provides an accurate evaluation of the cardiovascular lesions, reveals functional impairment and may guide the selection of interventional procedures. This article gives an overview of the clinical signs and symptoms of traumatic heart disease and discusses established diagnostic methods.
    Notes: Verletzungen des Herzens und der herznahen Gefäße sind keine seltene, oft aber eine Prognose bestimmende Komplikation bei einem Polytrauma. Es kann zwischen penetrierenden und stumpfen Verletzungen unterschieden werden; Letztere können bei initial oft fehlender klinischer Symptomatik in der Akutversorgung eines Verletzten der Diagnostik entgehen und werden dann erst später durch Herzinsuffizienz oder persistierende Rhythmusstörungen manifest. Die Schädigungen der verschiedenen kardialen Strukturen (Myokard, Perikard, Papillarmuskel, Klappenapparat, Koronararterien und Aorta) gehen mit einer mehr oder minder typischen Klinik einher und bewirken charakteristische Veränderungen, die mittels moderner diagnostischer Methoden sicher dargestellt werden können. Ganz im Vordergrund steht dabei die Ultraschalldiagnostik (transthorakal/ösophageal), die – im Gegensatz zu den radiologischen Verfahren wie CT und MRT – unmittelbar und mobil am Bett oder im Schockraum verfügbar ist. Mittels Ultraschall lassen sich nicht nur Ergussbildungen und Klappenläsionen oder Aneurysmen, sondern auch funktionelle Befunde wie Kontraktilitätsstörungen bei Myokardkontusion direkt darstellen. Das EKG und die laborchemischen Untersuchungen sind nur in besonderen Fällen wegweisend.
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  • 93
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    Trauma und Berufskrankheit 2 (2000), S. 19-27 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Azetabulumfrakturen ; Epidemiologie ; Diagnostik ; Klassifikation ; Keywords ; Acetabular fracture ; Epidemiology ; Diagnosis ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Acetabular fractures are typical lesions of polytraumatized patients. Therefore, treatment of these fractures has to be planned according to the overall trauma damage. ¶Adequate therapy is impossible without correct diagnosis and classification of the fracture. Conventional X-ray images including an anteroposterior view of the pelvis and obturator and iliac oblique views allow correct fracture classification according to the criteria of Letournel and the AO classification in most cases. To determine what therapeutic procedure will be adequate, it is important to evaluate the acetabular fracture by a synoptical analysis with comprehensive conventional X-ray diagnosis and a CT scan. Only ¶the CT scan allows reliable assessment of complex fractures, concomitant femoral head and pelvic fractures, intra-articular fragments and lesions preventing correct repositioning, and exact determination of the joint congruity. Three-dimensional CT ¶reconstruction should be reserved for planning the therapy in selected cases and for scientific examinations.
    Notes: Azetabulumfrakturen treten typischerweise bei mehrfachverletzten und polytraumatisierten Patienten auf, sodass die Versorgung der Fraktur unter Berücksichtigung der Gesamtverletzung geplant werden muss. Die Basis für eine suffiziente Therapie stellen die korrekte Diagnostik und Klassifikation der vorliegenden Fraktur dar. Die Basisdiagnostik zum Nachweis einer Azetabulumfraktur bildet die konventionelle Röntgendiagnostik, welche die Beckenübersicht-, Ala- und Obturatoraufnahme umfassen muss. Dadurch lassen sich zwar die meisten Frakturen anhand der derzeit etablierten Klassifikationssysteme von Letournel u. Judet und der AO beurteilen. Zur Therapieplanung und Entscheidungsfindung hinsichtlich eines operativen oder konservativen Vorgehens hat sich allerdings die synoptische Betrachtung des Frakturverlaufs in der kompletten konventionellen Röntgendiagnostik sowie in der Computertomographie bewährt. Erst die computertomographische Diagnostik ermöglicht in den meisten Fällen die sichere Erfassung komplexer Frakturformen, Begleitverletzungen des Hüftkopfs und Beckenrings, intraartikulärer Fragmente und Repositionshindernisse sowie die exakte Beurteilung der Gelenkkongruenz. Die 3D-Rekonstruktion sollte ausgesuchten Frakturen zur Operationsplanung sowie wissenschaftlichen Untersuchungen vorbehalten bleiben.
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  • 94
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Metakarpallappen ; Sehnentransfer ; Primäre Rekonstruktion ; Keywords ; Metacarpal reverse flap ; Tendon transfer ; Primary reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The reverse dorsal metacarpal flaps combined with the extensor indicis tendon or extensor digiti minimi and its surrounding tissue and based on the second or fourth metacarpal artery, offers the possibility for extensor tendon reconstruction, even in cases with loss of the skin, soft tissue and dorsal corticalis of the proximal phalanx of the finger. These flaps can be transposed as reverse island flaps in primary surgery in a single step to cover the defect and to achieve a functional repair. In contrast to conventional techniques, which have so far had poor outcomes, in each of two cases we achieved a good range of active motion (0–10–100° and 0–20–60°) with good loading capacity.
    Notes: Der distal gefäßgestielte dorsale Metakarpallappen der Hand unter Verwendung der 2. Metakarpalarterie ermöglicht den Einschluss eines Segments der Sehne des M. extensor indicis und seines Gleitgewebes in den Lappen. Damit ist es möglich, bei der primären Unfallversorgung eine Rekonstruktion von Defekten des Mittelzügels der Streckaponeurose am Fingergrundglied vorzunehmen, auch wenn durch Haut- und/¶oder Weichteilverlust und Verlust der dorsalen Kortikalis des Grundglieds die Erfolgsaussichten mit herkömmlichen Methoden schlecht sind. Es werden 2 Fälle mit Transfer zum 2. und zum 3. Finger vorgestellt, wobei bei Handarbeitern ein aktiver Bewegungsumfang von 0/10/100° und 0/20/60° mit guter Belastbarkeit erreicht wurde. Der kombinierte Transfer von Lappen und Sehne erweitert die Möglichkeiten der primären Unfallwiederherstellung bei komplexen Handverletzungen.
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  • 95
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Verletzung der oberen Extremität ; Anästhesie ; Schmerztherapie ; Akutschmerz ; Arbeitsfähigkeit ; Keywords ; Upper limb injury ; Anaesthesia ; Pain therapy ; Acute injury pain ; Fitness for work
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The aim of this review is to demonstrate the various anaesthesiological techniques available for acute care and pain therapy in complications and residual impairments after upper limb injury. Several types of pain, such as that experienced as a result of acute injury, post-amputation syndrome, deafferentation pain, chronic regional pain syndrome and central and chronic pain, and the form of therapy applied for each are described. An interdisciplinary therapeutic approach is an important factor in the management of all such patients, the aim of this being to optimise the treatment results and to accelerate the restoration of fitness for work. Anaesthetists can make an effective contribution to this with different anaesthesiological and algesiological techniques.
    Notes: Anliegen dieser Übersichtsarbeit ist es, die vielfältigen Anästhesieverfahren zur Akutversorgung und Schmerztherapie von Komplikationen und Spätfolgen bei Verletzungen der oberen Extremität darzustellen. Schmerzzustände wie der Akutschmerz, das Postamputationssyndrom, der Deafferenzierungsschmerz, das Chronic-regional-pain-Syndrom sowie zentraler und chronischer Schmerz und deren Therapie werden erläutert. Die interdisziplinäre Zusammenarbeit stellt einen wichtigen Faktor in der Behandlung des Patienten dar, mit dem Ziel, das Behandlungsergebnis zu optimieren und so die Wiedererlangung der Arbeitsfähigkeit zu beschleunigen. Hierbei kann der Anästhesist mit anästhesiologischen und algesiologischen Techniken einen wirkungsvollen Beitrag leisten.
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  • 96
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    Trauma und Berufskrankheit 2 (2000), S. 358-363 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Heterotope Ossifikationen ; Rückenmarkverletzte ; Operative Behandlung ; Schulter ; Ellbogen ; Keywords ; Heterotopic ossification ; Spinal cord injuries ; Operative treatment ; Shoulder ; Elbow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Heterotopic ossification (HO) is a common complication after severe trauma, although its exact cause is still unknown. Ultrasound screening has been described for the hip joint. HO of the shoulder and elbow as a functional unit is rare, but causes a crucial reduction of the mobility in the nonparalysed or only partially paralysed joints in para- and tetraplegics. Ankylosing HO leads to pain and to further restrictions on independent living. With the aims of restoring joint function and relieving pain we performed a prospective trial of resection of HO in seven patients. The operations were not performed until the HO had definitively run its course. Tendon transfers were performed to restore muscle function in three cases. Postoperative follow-up showed decreased joint motion but increased patient comfort. We avoidedrecurrence of HO by means of preoperative radiation, careful operation techniques and consistent physiotherapy regimens.
    Notes: Heterotope Ossifikationen (HO) treten in Folge einer Vielzahl von meist traumatischen Erkrankungen auf. Die Genese der HO ist nach wie vor ungeklärt. Sonographische Screeningmethoden sind für die Hüftgelenke beschrieben. HO der Schulter- und Ellbogengelenke als funktionelle Einheit sind relativ selten, führen aber gerade bei Querschnittgelähmten zu massiven Funktionseinbußen der nicht- bzw. nur teilgelähmten Extremitäten. Ankylosierende HO führen zu Schmerzen und zusätzlich zu einer weiteren Verringerung der Selbstständigkeit. Zur Funktionswiederherstellung der Gelenke und zur Schmerzlinderung wurden bei 7 Patienten im Rahmen einer prospektiven Untersuchung Resektionen der HO durchgeführt. Die Operationen erfolgten erst nach sicherer Ausreifung der HO. In 3 Fällen wurden parallel Sehnentransfereingriffe zum Ersatz gelähmter Muskelgruppen vorgenommen. Obwohl es zu einer Reduktion der absoluten Bewegungsmaße im Vergleich intra- zu postoperativ kam, war der Großteil der so versorgten Patienten subjektiv zufrieden. Rezidive traten nicht auf, u. E. ist dies sowohl auf die direkt präoperativ erfolgte Bestrahlung, die schonende Operationstechnik und zeitliche Indikationsstellung als auch auf das konsequente physiotherapeutische Nachbehandlungskonzept zurückzuführen.
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  • 97
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Pflegeüberleitung ; Ältere Menschen ; Qualitätssicherung ; Versorgungskette ; Unfall ; Keywords ; Care transition ; Elderly ; Quality assurance ; Support system ; Accident
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: This article describes an undergraduate research project being carried out in cooperation with the Institute for Health and Nursing Sciences and the occupational mutual benefit organization in Halle (Saale). A patient priority summary for care transition was developed to meet the need for documentation to guarantee continuous transfer of information on patients between nurses and other health care providers after discharge from hospital. It was very important to display an integrative point for all health care providers and to improve transparency for patients and their families. The procedure itself was process oriented: (1) the stage of identification, relating to the objectives of the project, and (2) the stage of conceptualization, testing its significance in practice, describing the current status of discharge practice and including a document analysis. The subsequent development of a form for managed care was validated by experts. It was pretested in a population of 35 patients over 64 years of age who had undergone surgery after accidents. According to the project’s aim, after discharge patients were interviewed by telephone according to a structured interview design. The results refer to the realization of defined objectives of the project, the integrative approach, the acceptance by patients in the sense of self-determination, the quality of the documentation and the value of using of the transition form as estimated by nurses. The patient priority summary for care transition can be seen as a practically useful tool for information transfer between health care providers, covering the patient’s perspective.
    Notes: Es wird ein studentisches Forschungsprojekt in Zusammenarbeit zwischen dem Institut für Gesundheits- und Pflegewissenschaft und den BG-Kliniken Bergmannstrost, Halle, Saale, beschrieben, das sich mit der Einführung eines Patientenüberleitungsbogens (PÜB) mit dem Ziel der Entwicklung eines Dokumentationsinstruments zur kontinuierlichen Informationsweitergabe an die Pflegenden und andere, an der nachstationären Versorgung beteiligten Berufsgruppen unter den Prämissen eines integrativen, Berufsgruppen übergreifenden Ansatzes befasste. Zugleich sollte mehr Transparenz für Patienten und deren Angehörige geschaffen werden. Das methodische Vorgehen war prozessorientiert: in der Identifikationsphase wurden die Ziele des Projekts untersucht, die Konzeptionsphase diente der Überprüfung der Praxisrelevanz, des Iststands der Entlassungsmodalitäten und einer Dokumentenanalyse und daran anschließend der Entwicklung eines Überleitungsbogens und dessen Überarbeitung nach der Überprüfung durch Experten. Die Pretestphase beinhaltete 35 unfallchirurgisch versorgten Patienten, die zum Zeitpunkt der Untersuchung älter als 64 Jahre waren. Diese wurden telefonisch mittels Interviewleitfaden zur Weitergabe des Überleitungsbogens durch die Patienten entsprechend der Zielstellung nachbefragt. Die Ergebnisse beziehen sich neben dem Resultat der Dokumentenanalsye und der Beschreibung der Stichprobe auf die Verwirklichung der definierten Ziele, den integrativen Ansatz, die patientenseitige Akzeptanz im Sinn von Selbstbestimmung, die Qualität der Dokumentation und die Einschätzung des PÜB aus der Sicht der stationär Pflegenden. In dem Patientenüberleitungsbogen ist ein praktikables Instrument zur Informationsweitergabe in der Versorgungskette unter Einbeziehung des Patienten zu sehen; neben der Verbesserung einiger methodischer Aspekte sollten zukünftig Barrieren für die Integration der Berufsgruppen übergreifenden Information analysiert und minimiert werden. Für die spezifischen Vorgaben der gesetzlichen Unfallversicherung in Bezug zu den Behandlungszielen und zur Bemessung des Pflegegelds kann der Bogen nach spezifischer Adaption ein aussagefähiges, spezifisches Dokumentationsinstrument sein.
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  • 98
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    Springer
    Trauma und Berufskrankheit 2 (2000), S. 46-59 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Azetabulumfrakturen ; Konservative Therapie ; Operative Therapie ; Keywords ; Acetabular fractures ; Conservative therapy ; Operative therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Apart from conservative therapy with or without traction, the main methods of treating acetabular fractures are open reduction and internal fixation. The primary aim is the most exact restoration possible of articular congruence in order to avoid complications. Adequate therapy is not possible without accurate radiographical diagnosis and analysis of the fracture. When a therapy is selected, it is also necessary to take the patient’s age, any associated injuries and the surgeon’s ¶experience into account. The types of fractures considered especially suitable for conservative therapy are lower fractures of the anterior column, lower transverse fractures with secondary articular congruence and avulsions of the posterior wall that have no effect on articular stability. Conservative treatment demands a high measure of medical supervision and a great deal of physiotherapy and aftercare. Surgical treatment is indicated for dorsal posterior wall and column fractures with dislocation and for high transverse fractures and fractures in the cranial column area or weight-bearing dome. Further indications are failed closed reduction of the femoral head, interposition of soft tissue, and acetabular fractures with fractures of the femoral head (Pipkin IV). For patients with multiple traumas, who cannot be treated primarily with internal fixation, traction is indicated as the initial treatment. The timing of the operation is crucial to the quality of the reduction and to the long-term result.. Older patients are a special group because of the many associated diseases they have and their osteopenic bone structure. In such patients too, restoration of the articular congruence is of the utmost importance. The main alternative to conservative treatment and internal fixation is the implantation of a primary or secondary endoprothesis. The main problem encountered with prothetic implants, which require a firm anchorage, is premature loosening.
    Notes: Die offene Reposition und interne Osteosynthese stellt neben der konservativen Heilbehandlung das hauptsächliche Therapieverfahren bei Azetabulumfrakturen dar. Primäres Ziel ist die möglichst exakte Wiederherstellung der Gelenkkongruenz, um Spätfolgen, insbesondere die posttraumatische Arthrose, zu vermeiden. Voraussetzung einer adäquaten Versorgung sind eine exakte Röntgendiagnostik und Frakturanalyse. In die Therapieentscheidung müssen zudem das Alter des Patienten, Begleitverletzungen und Erfahrungen des Chirurgen einfließen. Für eine konservative Behandlung, die ein hohes Maß an ärztlicher Überwachung und physiotherapeutischer Begleit- und Nachbehandlung erfordert, kommen v. a. niedrige Frakturen des vorderen Pfeilers, niedrige Querfrakturen, 2-Pfeiler-Frakturen mit sekundärer Gelenkkongruenz sowie Abrissfrakturen der Hinterwand, die keinen Einfluss auf die Gelenkstabilität ausüben, in Betracht. Operationsindikation besteht bei dorsalen Pfannenrand- und Pfeilerfrakturen mit Dislokation, hohen Querbrüchen, Frakturen im Bereich des kranialen Pfeilers, nach fehlgeschlagenen geschlossenen Repositionen des Femurkopfs, bei Weichteilinterpositionen und Azetabulumfrakturen mit Kopfkalottenfrakturen. Bei polytraumatisierten Patienten, die primär keiner Osteosynthese zugeführt werden können, ist zunächst eine Extensionsbehandlung indiziert, wobei der Operationszeitpunkt für die Repositionsqualität und das anschließende Langzeitergebnis eine entscheidende Rolle spielt. Ältere Patienten stellen aufgrund ihrer vielfach vorliegenden Begleiterkrankungen und osteopenischen Knochenstruktur eine besondere Behandlungsgruppe dar. Auch hier gilt in ersten Linie die Wiederherstellung der Gelenkkongruenz. Neben der konservativen Behandlung und internen Osteosynthese steht die primäre oder sekundäre Endoprothetik zur Diskussion. Hauptproblem der primären Prothesenimplantation ist die frühzeitige Prothesenlockerung.
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  • 99
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    Trauma und Berufskrankheit 2 (2000), S. 86-92 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Ungebohrter Tibiamarknagel ; UTN ; Tibiafraktur ; Keywords ; Unreamed tibial nail ; UTN ; Tibial fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: In many situations where tibial nailing is indicated unreamed nails are now preferred; their use has almost superseded reamed nailing. This development is illustrated with reference to two groups of patients, and the resulting treatment concept is presented in this paper. In a secondary clinical introduction period of this implant at our hospital, within 9 months 40 out of 61 tibial fractures for which nailing was indicated were treated with unreamed tibial nails (UTN). This was the primary treatment in 19 of these cases and a secondary treatment in 21; review of 35 of the fractures was possible after an average of 10 months. According to the AO classification, 85% of these fractures belonged to groups A and B, and the remaining 15% were group C fractures; there was a high incidence of closed and open soft tissue damage: G0 = 6; G1 = 8; G2 = 6; O1 = 6; ¶O2 = 13; O3 = 1. The following complications were observed: 2 haematomas needed to be evacuated (no infections appeared). In 1 case nonpersisting peroneal palsy was observed. Nonunion was observed in 2 cases. In the 33 directly healed fractures the average time taken for consolidation was 15 weeks (12–20 weeks). Over half the patients (65.7%) were found to be free of pain and to have an uninhibited range of movement even during full weight bearing. In 42.8%, however, kneeling was painful, but this should improve after removal of the implant.
    Notes: In vielen Indikationen hat die Marknagelung in ungebohrter Technik die in gebohrter Technik wieder verdrängt. Diese Entwicklung wird anhand von 2 Kollektiven nachgezeichnet, und das resultierende Behandlungskonzept für Unterschenkelfrakturen mit „Nagelindikation“ wird vorgestellt. In der 2. Einführungsphase des Implantats an der Abteilung Unfallchirurgie, Chirurgische Universitätsklinik Freiburg, wurden in einem Zeitraum von 9 Monaten 40 von 61 Unterschenkelfrakturen mit Nagelindikation mit dem UTN versorgt, 19 primär und 21 sekundär. Davon konnten 35 Frakturen nach einem durchschnittlichen Intervall von 10 Monaten nachuntersucht werden. Bei der AO-Klassifikation überwogen mit 85% die Frakturen der Gruppe A und B, die restlichen 15% der Frakturen waren Gruppe C zuzuordnen. Das Kollektiv wies einen hohen Anteil an geschlossenen und offenen Weichteilschäden auf: G0: 6; G1: 8; G2: 6; O1: 6; O2: 13; O3: 1. ¶Postoperativ mussten 2 Hämatome ausgeräumt werden (Bakteriologie negativ), ¶Infekte traten nicht auf. In 1 Fall kam es zu ¶einer passageren Peronäusparese, in 2 Fällen zur Ausbildung von Pseudarthrosen. Bei den 33 direkt verheilten Frakturen betrug die durchschnittliche Konsolidierungszeit 15 Wochen (12–20 Wochen). In 65,7% der Fälle wurden bei Vollbelastung Schmerzfreiheit und ein freies Gangbild gefunden. Häufig bereitet eine Einschränkung beim Knien aufgrund von Schmerzen an der Insertionsstelle Probleme (42,8%).
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  • 100
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    Springer
    Trauma und Berufskrankheit 2 (2000), S. 157-161 
    ISSN: 1436-6274
    Keywords: Schlüsselwörter ; Spätrekonstruktion ; Halswirbelsäule ; Ventrale Spondylodese ; Dorsales Release ; Keywords ; Late reconstruction ; Cervical spine ; Ventral spondylodesis ; Dorsal release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Indications for late reconstructive surgery at the cervical spine result from chronic instability, old displacements that had originally been overlooked, or delayed progressive neurological malfunction. In most cases, the reduction demands a combined dorsoventral procedure including posterior release and anterior fusion. In the presence of neurological deficits, additional decompression techniques are recommended. Another reason for late reconstruction at the upper cervical spine is given in the presence of dens pseudarthrosis following fractures of Anderson type II, for which atlanto-axial fusion is the procedure of choice.
    Notes: Am häufigsten ergibt sich die Indikation für spätrekonstruktive Eingriffe an der Halswirbelsäule bei chronischen Instabilitäten, veralteten, primär übersehenen Luxationen sowie sekundär auftretenden progredienten neurologischen Symptomen. Die Reposition erfordert meist das kombiniert dorsoventrale Vorgehen, bei neurologischen Symptomen sind nicht selten zusätzliche dekomprimierende Maßnahmen notwendig. Eine häufige Ursache für Spätversorgungen an der oberen Halswirbelsäule besteht bei Denspseudarthrosen nach Frakturen vom Typ Anderson II, hier wird der atlanto-axialen Fusion der Vorzug gegeben.
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