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  • 1975-1979  (1,153)
  • 1890-1899
  • Electron microscopy  (597)
  • Ultrastructure  (563)
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in the distal wing bud of the chick embryo after removal of the apical ectodermal ridge (1979)
    Springer
    Development genes and evolution 185 (1979), S. 333-346 
    Details
    ISSN: 1432-041X
    Keywords: Chick embryo ; Limb bud ; Ultrastructure ; Cell death
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ultrastructural changes in the wing bud afterapical ectodermal ridge (A.E.R.) removal was studied to re-examine the issue of distal mesenchymal cell death. The A.E.R. of the right wing bud was removed microsurgically from chick embryos of stages 18 to 22 (HH 1951). The wing buds were examined at three hour intervals up to twelve hours after the operation with light, transmission and scanning electron microscopy. The main findings were: (1) Immediate and temporary shrinkage of the mesenchymal extracellular space 100 to 150 μm and chromatin condensation in the cells 50 to 75 μm from the wound. (2) Death of ectodermal and mesenchymal cells in the immediate vicinity of the wound. (3) Formation of a single squamous-like layer of mesenchymal cells to cover the wound. (4) Occasional evidence of cell death in the distal mesenchyme at later times after the operation. The pattern of cell death observed suggests only a traumatic etiology, and gives little evidence for the postulated developmental significance of cell death following A.E.R. removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848520
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of collagen in sea urchin embryos (1979)
    Springer
    Development genes and evolution 186 (1979), S. 65-70 
    Details
    ISSN: 1432-041X
    Keywords: Sea urchin ; Embryo ; Collagen ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Collagen fibrils with a main period banding of 610 Å and 220 Å in width were observed in the blastocoel of 72-h embryos of the sea urchin,Strongylocentrotus purpuratus. Non-striated fibrils of 50 Å diameter were also observed. The collagen is seen in highest concentration in the vicinity of mesenchyme cells which are richly endowed with endoplasmic reticulum and secretory vesicles. A role for collagen in cell attachment, orientation and spicule formation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848108
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  • 3
    Electronic Resource
    Electronic Resource
    On the ultrastructure of the parotid gland in miniature pigs (1979)
    Springer
    Anatomy and embryology 155 (1979), S. 23-36 
    Details
    ISSN: 1432-0568
    Keywords: Parotid gland ; Miniature pig ; Electron microscopy ; Innervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This communication reports on the morphology of the parotid gland of miniature pigs (Göttingen strain). 1. The glandular system consists in its terminal portions of acinar secretory parts. Between the basal lamina and the secretory epithelial cells myoepithelial cells are located. 2. The cytoplasmic organization of the acinar cells represents the features of mucous secretory cells. By electron microscopic means, light secretory granules have been demonstrated which frequently are coalescent. Between the bulk of secretory material only small remnants of cytoplasm are visible. The electron dense nuclei are located in basal parts of the cells. Intercellular canaliculi have not been observed. 3. The intercalary ducts, located between the acinar portions and the striated ducts of the gland, are long and narrow tubules, frequently branched. Their epithelium is simple cuboidal, and there is no indication of any secretory activity. 4. The epithelium of the striated ducts is simple columnar. The orientation of mitochondria parallel to the cell axis, and also the invaginations of the basal cell membrane give the basal cytoplasm a vertically striated appearance. 5. The paravascular nerves of the gland's connective tissue consist of bundles of unmyelinated axons. These branch into smaller bundles, and finally into single unmyelinated axons which reach the acinar portions. These axons appear to be only partly surrounded by Schwann cells. Very thin axons alone penetrate the basal lamina and reach the secretory cells of the acini; moreover, these axons may occasionally reach the intercellular spaces between the secretory cells. Within these terminal parts of the axons groups of synaptic vesicles appear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315728
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural and biochemical observations on the metanephros of normal and cultured chick embryos (1979)
    Springer
    Anatomy and embryology 155 (1979), S. 95-105 
    Details
    ISSN: 1432-0568
    Keywords: Metanephros ; Chicken embryo ; Ultrastructure ; Parathyroid hormone ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A comparative electron microscopical study was conducted on the metanephros from chick embryos differentiated either in shell-less culture or in ovo. Developmental characteristics were very similar in both cases. Up to stage 37 (Hamburger-Hamilton) the metanephros contained large numbers of immature nephrons; their renal corpuscles were crescent-shaped and consisted of an outer layer of flat cells and an inner one of cuboidal cells. In more advanced corpuscles also found at this stage the inner layer had formed numerous rudimentary pedicels and the tunica media of the glomerular arteriole contained juxta-glomerular cells with numerous, small, electron dense granules. In the metanephros from embryos at stage 38 or older, large numbers of nephrons had completed their differentiation; their rounded renal corpuscles had fully differentiated podocytes with thin interdigitating pedicels and the proximal convoluted tubules had numerous apical microvilli, vesicles, vacuoles and tubular invaginations indicating an active process of resorption. These results appear to indicate that both in culture and in ovo-developed embryos, the metanephri start to function around stage 38. In the case of normal embryos this conclusion agrees with previous physiological and biochemical determinations. The injection of 20 USP parathyroid hormone into 16-day old chick embryos produced an increase in the concentration of cyclic AMP in the metanephros. This favours the idea that the regulation of kidney function by the hormone begins during the embryonic period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315734
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural observations on closure of the neural tube in the mouse (1979)
    Springer
    Anatomy and embryology 156 (1979), S. 73-88 
    Details
    ISSN: 1432-0568
    Keywords: Closure ; Development ; Mammalina embryo ; Neural tube ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fusion of the neural walls in the cephalic part of mouse embryos varying in age from 9 to 20 somites was examined with the electron microscope. In the rhombencephalic region the rim of the neural wall was formed from outside inward by ectodermal surface cells, a row of flattened cells without surface projections and neuroepithelial cells. At the junction of the surface ectoderm and the flat cells were seen large projections containing a cytoplasmic matrix without organelles and previously referred to as “ruffles”. The initial contact between the walls was made by the large cytoplasmic arms and numerous finger-like projections interdigitating with similar projections from the opposite wall. The projections originated from the surface ectoderm and possibly neural crest cells. During further fusion the surface ectoderm cells formed dense membrane specializations, thus establishing a firm contact. The initial contact in the mesencephalon was formed by extensions from the surface ectoderm and was followed by the formation of specialized membrane junctions, as seen between the surface ectoderm in the rhombencephalon. The neuroepithelial cells facing the gap between the neural walls with their apical ends made contact with the cells from the opposing wall by numerous finger-like projections but membrane specializations failed to develop. The closing mechanism in the prosencephalon and anterior neuropore regions differed from the previous areas in that the initial contact was established by the neuroepithelial cells. Only after this contact had been formed did the surface ectoderm cells close the gap. In contrast with the other areas many phagocytosed particles were seen in the prosencephalon and in the region of the anterior neuropore. Many particles from degenerated cells were found inside healthy surrounding cells. Some of these particles contained nuclear material and cytoplasmic organelles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315716
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  • 6
    Electronic Resource
    Electronic Resource
    An electron microscopic study of periderm cell development in mouse limb buds (1979)
    Springer
    Anatomy and embryology 157 (1979), S. 121-132 
    Details
    ISSN: 1432-0568
    Keywords: Limb bud ; Periderm ; Apical ectodermal ridge ; Electron microscopy ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Development of periderm cells covering fore-and hindlimb buds of mouse em`ryos was observed by scanning and transmission electron microscopy at half day intervals from day 9.5 to 12.5 of gestation (vaginal plug=day 0). At day 9.5, the epidermis is single layered. Occasional periderm cells are present at day 10.5. By day 11.5 a complete layer of periderm cells has covered the entire limb bud. By scanning electron microscopic observation, periderm cells covering the apical ectodermal ridge (AER) are characterized by a small surface size and an elongated polygonal shape with the long axis parallel to the antero-posterior contour of the apical rim. Periderm cells covering the dorsal and ventral surfaces of the limb bud are relatively large and have a polygonal surface shape. The periderm covering the apical tip reflects well the developmental state of the AER. Hence, it is possible to estimate the development of the AER by observing the surface features of the apical periderm by scanning electron microscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305153
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  • 7
    Electronic Resource
    Electronic Resource
    Intercellular junctions in the full term human placenta (1979)
    Springer
    Anatomy and embryology 158 (1979), S. 41-50 
    Details
    ISSN: 1432-0568
    Keywords: Placenta (human) ; Syncytiotrophoblast ; Intercellular junctions ; Electron microscopy ; Freeze-fracturing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inter-and intrasyncytiotrophoblastic junctions within the human full term placenta were electronmicroscopically investigated using thin sections and freeze-fracturing. Narrow clefts were occasionally situated between surface areas where adjacent chorionic villi exhibited close contact. Whithin these clefts, extensive zonulae and maculae occludentes and numerous maculae adherentes were found. The zonulae occludentes showed a continuous and irregular course on the membrane surface, and the maculae occludentes were irregularly distributed over extended membrane areas. Besides these areas, maculae occludentes and maculae adherentes were observed on infoldings and invaginations of the syncytiotrophoblastic surface membrane. Investigations of the inner surface of the syncytiotrophoblastic layer, that is, the layer facing the villous stroma, also revealed invaginations joined by maculae adherentes. The functional significance of the inter-and intrasyncytiotrophoblastic junctions is discussed with respect to the differentiation of the trophoblast.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315950
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructural changes in the rat metrial gland in the latter half of pregnancy (1979)
    Springer
    Anatomy and embryology 155 (1979), S. 209-219 
    Details
    ISSN: 1432-0568
    Keywords: Electron microscopy ; Metrial gland (rat) ; Pregnant uterus ; Degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural changes occurring in the metrial gland in the latter half of pregnancy in the rat have been studied. Typical palely stained granulated cells are present in the metrial gland up to day 20 but many granulated cells show variations in appearance which may be associated with degeneration. In some the cytoplasm is more darkly stained and such cells often have apparently empty areas of cytoplasm adjacent to the granules. From day 14 onwards many areas of the gland show cellular debris, apparently resulting from lysis of the granulated cells. However, occasionally normal granulated cells are present in blood vessels and have been observed apparently penetrating the vascular endothelium. A variety of changes was also noted in the stromal cell population. Inclusions became apparent in many of these cells; some of these consisted of lipid while others resembled granules from the typical granulated cells. Other cells with numerous inclusions appeared to be macrophages. Lysis of granulated cells in situ is compatible with suggestions that the metrial gland produces a holocrine secretion, though some normal granulated cells enter blood vessels. The stromal cells may have a phagocytic role in late pregnancy but evidence for this was inconclusive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305753
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  • 9
    Electronic Resource
    Electronic Resource
    Lipofuscin in the cerebellar cortex of albino rats: An electron microscopic study (1979)
    Springer
    Anatomy and embryology 155 (1979), S. 333-345 
    Details
    ISSN: 1432-0568
    Keywords: Lipofuscin ; Cerebellar cortex ; Ultrastructure ; Senescent rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of autofluorescent, PAS-positive lipofuscin in Purkinje, granule, Golgi epithelial, basket and stellate, microglial and perivascular cells in the cerebellar cortex of senescent rats is described. The membrane-bounded pigment is composed of three elements: 1) electron-lucent homogeneous droplets, 2) a granular matrix and 3) intensely osmiophilic patches. The proportions of these three components vary between cell types and one can grossly differentiate a neuronal and a glial lipofuscin. The lipofuscin granules of stellate and perivscular cells are different from lipofuscin of other cerebellar neurons and glia. It can be concluded from these morphological observations that each cerebellar cell type has its distinct lipofuscin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317646
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  • 10
    Electronic Resource
    Electronic Resource
    Comparative studies on the pre-and postterminal blood vessels in the cerebellar cortex of rhesus monkey, cat, and rat (1979)
    Springer
    Anatomy and embryology 158 (1979), S. 51-62 
    Details
    ISSN: 1432-0568
    Keywords: Cerebellar cortex ; Pre-and postterminal blood vessels ; Rhesus monkey, cat, rat ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the rhesus monkey, cat and rat, pial arteries give off branches which run vertically through all three layers of the cerebellar cortex. The large cortical arteries are surrounded by a perivascular space in the molecular layer. Their wall consists of several layers of smooth-muscle cells and the luminal endothelium. As the arteries reach the deeper layers of the cerebellar cortex, the number of smooth-muscle cells is reduced. In the rat, sometimes no smooth-muscle cells are detectable in the preterminal arterial vessels. If these deep arteries branch off by dichotomy of terminal vessels there occurs a gradual or complete loss of myocytes in all three species. In the cat, where cortical arteries give off branches at rightangles, there is a sphincter-like accumulation of smooth-muscle cells at the opening to the smaller branch. The postterminal vessels and veins in all species exhibit the smae mural structure found in capillaries. The wall consists only of an endothelium and occasional pericytes embedded in the basal lamina. Even the large veins which run to the pial veins show this simple mural structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315951
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  • 11
    Electronic Resource
    Electronic Resource
    In vitro studies on the self-differentiating capacities of quail adenohypophysis epithelium (1979)
    Springer
    Anatomy and embryology 156 (1979), S. 255-267 
    Details
    ISSN: 1432-0568
    Keywords: Adenohypophyseal rudiment ; Self-differentiation ; Ultrastructure ; Quail
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Isolated epithelial rudiments of 3–4 days quail embryo adenohypophysis were cultivated in vitro. Differentiation of glandular cells occured when culture conditions allowed the formation of explants characterized by the presence of a fibroblastic sheet and of an epithelial roof surrounding a central cavity. Differentiation did not occur when culture conditions did not allow the fibroblastic sheet to be established or resulted in the absence of a cavity. The importance of the explant structure in differentiation is also indicated by the location of glandular cells. In vitro they differentiate near the cavity derived from Rathke's pouch lumen while in situ they first appear at the periphery of the rudiment, near the basement membrane. The results of this study show that the adenohypophyseal primordium can differentiate without any mesenchymal influence. The observed differentiation seems to be correlated with fibroblast-secreted material, and this hypo-thesis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299626
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  • 12
    Electronic Resource
    Electronic Resource
    The fine structure of subcortical neurofibrillary tangles in progressive supranuclear palsy (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 147-152 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Neurofibrillary tangles ; Electron microscopy ; Straight filaments ; Twisted tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of subcortical neurofibrillary tangles was investigated in pallidum, substantia nigra, periaqueductal gray, pontine reticular gray, and dentate nucleus of 5 autopsy cases of Progressive Supranuclear Palsy. Only tangles due to straight 150 Å wide filaments have been detected. These findings, obtained from a large series of cases and areas examined, confirm previous observations on the fine structure of neurofibrillary tangles in Progressive Supranuclear Palsy and suggest that the association between tangles due to straight filaments and tangles due to twisted tubules, so far described in one case, is probably exceptional.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691893
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  • 13
    Electronic Resource
    Electronic Resource
    Cell origin of human adenovirus type 12-induced subcutaneous tumor in Syrian hamsters (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 187-194 
    Details
    ISSN: 1432-0533
    Keywords: Human adenovirus 12 ; Hamsters ; Subcutaneous neuroblastomatous tumor ; T-antigens ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single subcutaneous inoculation of human adenovirus type 12 (Ad. 12), 0.05–0.1 ml of 108.0 TCID50 HEK cells/0.1 ml, was made on the back of 0-day-old hamsters. In 21 of 25 hamsters (84.0%), multiple solid tumors developed close to the inoculation site within 3 months. No control hamsters developed tumors. Tumor histopathology revealed the characteristic Homer Wright rosettes of neuroblastoma. Ad. 12-specific tumor antigens were demonstable in both the primary and the cultured tumor cells by the hnmunofluorescein technique. Histochemical demonstration of cholinesterase and NADH oxidoreductase gave rise to a predominantly positive intracytoplasmic granule within the tumor cells. Electron microscopy showed remarkably iniform cell morphology: small, undifferentiated neuroblastic cells with poorly developed intracytoplasmic organelles; many possessed characteristic solitary cilia in a 9+0 tubules pattern. Intercellular junctions were poorly developed. Search for an incipient tumor cell aggregate by means of immunofluorescein T-antigen detection was carried out through a 240-h period following Ad. 12 inoculation. A sequential study in parallel with electron microscopic examination of the normal subcutaneous tissue proved that neuroblastic cells closely associated with the muscle spindle anlage could preferentially become the most sensitive target for Ad. 12 tumorigenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702670
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  • 14
    Electronic Resource
    Electronic Resource
    Production of myelin by neoplastic cells (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 241-245 
    Details
    ISSN: 1432-0533
    Keywords: Myelin formation ; Ganglioglioma ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Formation of myelin sheaths by neoplastic cells was found in a spinal ganglioneuroma. All phases of initial myelination were observed including the formation of a mesaxonal spiral and the fusion of its famellae into a major dense line. A unique aspect of neoplastic myelin formation was the formation of sheaths around bundles of extracellular fibrils rather than axons or cell processes. Formation of myelin sheaths around extracellular material has never been observed before. The findings have implications on the mechanisms controlling initial myelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702676
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  • 15
    Electronic Resource
    Electronic Resource
    The morphopathologic substrates of concussion? (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 1-11 
    Details
    ISSN: 1432-0533
    Keywords: Experimental Concussion ; Peroxidase, neuronal uptake ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal inundation with i.v. infused horseradish peroxidase was studied following concussive brain injury by means of both light and electron microscopy. In animals sustaining mechanical brain injury of insufficient intensity as to elicit either microscopic intraparenchymal hemorrhage or other neuropathological change, yet of sufficient intensity as to provoke a physiological concussive response, vascular peroxidase exudation concomitant with neuronal peroxidase inundation occurred throughout the raphe and reticular core. Initially such inundated neurons were totally flooded with the tracer and as such appeared reminiscent of cells visualized in Golgi preparations. However, over the course of a 24-h period these peroxidase flooded neurons apparently organized the peroxidase into vesicles and vacuoles which assumed a perinuclear position from where the peroxidase ultimately reached both the nucleus und nucleolus. It was remarkable that these events occurred without any evidence of subcellular alteration. We interpret such initial inundation with this protein tracer, its ultimate reorganization, and its nuclear and nucleolar uptake as being consistent with some form of subtle and transient neuronal perturbation. We speculate that as such this neuronal perturbation may constitute a morphological correlate of the concussive episode.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698266
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  • 16
    Electronic Resource
    Electronic Resource
    Electron microscopical demonstration of nucleic acids in virus-like particles in the skeletal muscle of a traffic accident victim (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 55-59 
    Details
    ISSN: 1432-0533
    Keywords: Virus-like particle ; Nucleic acid ; Muscle ; Cytochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Picornavirus-like crystalline arrays were found in the skeletal muscle of a victim of a traffic accident. Individual particles measured approximately 22 nm in diameter and were arrayed in a hexagonal or triangular pattern. Cis-platinum (II) staining of these virus-like particles showed that these particles were not glycogen but contained nucleic acids, and the staining according to Bernhard also showed these particles contained RNA. Through the combination of the methods of Heinen (1977) and Bernahrd (1969), we can confirm that virus-like crystalline structures found electron microscopically contain nucleic acids and possibly represent virions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698273
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  • 17
    Electronic Resource
    Electronic Resource
    Barriers and transport properties of the perineurium (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 139-143 
    Details
    ISSN: 1432-0533
    Keywords: Perineurium ; Permeability ; Peripheral nerve ; Rat ; Ultrastructure ; Autoradiography ; Albumin ; Peroxidase ; Protein deprivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The permeability properties of the perineurium in sciatic nerves of 12-week-old rats were studied. The penetration of125I-labeled albumin and horseradish peroxidase into the perineurium was investigated electronmicroscopically 10, 30, and 120 min after the local extraneural application of the tracers. The autoradiographic study included age-matched protein-deprived rats. It was concluded that the perineurium acted as a diffusion barrier but also permitted a slow passage of the macromolecules into the endoneurium. The result indicates that this penetration to some extent is due to vesicular transport across the perineurial cells. The significance of these barrier and transport properties of the perineurium is discussed. No obvious differences in perineurial permeability between normal and protein-deprived rats were obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717037
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  • 18
    Electronic Resource
    Electronic Resource
    Normal and benzo(a)pyrene-transformed fetal mouse brain cells (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 205-211 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor cells ; Chemical carcinogen ; Benzo(a)pyrene ; Oncogenesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study was performed on normal and Benzo(a)-pyrene (B(a)P)-transformed fetal mouse brain cells. Early subcultures of a strain initiated from whole brain presented three cell types in vitro: astroglial, poorly differentiated glial, and spongioblastic types. After B(a)P-treatment, there was an exclusive transformation and the growth of neuroglia sometimes without gliofibrillary maturation, but with the presence of glial fibrillary acidic protein (GFAP) in the cytoplasm. Early subcultures of another strain initiated from cortex only presented poorly differentiated neuroglial cells. After transformation, cell maturation as evidenced by gliofibrillogenesis and GFAP production by these cells was observed. In both cases, the potentiality of glial differentiation after in vitro malignant transformation by a chemical carcinogen seemed preserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690548
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  • 19
    Electronic Resource
    Electronic Resource
    Herpes simplex type 2 encephalitis concurrent with known cerebral metastases (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 237-240 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex type 2 ; Herpes simplex encephalitis ; Cerebral metastasis ; Metastases and viral encephalitis ; Immunofluorescence ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 62-year-old woman developed neurologic deficits 7 months after pulmonary lobectomy for alveolar cell carcinoma of the lung. CT scan of the head demonstrated two metastases with marked peritumoral edema. Administration of Decadron, chemotherapy and 3,000 rad cranial radiation resulted in dramatic inprovement of dysphasia and right hand paresis. Almost 2 months later, rhythmic, involuntary movements of the left hand developed. There was progression to multifocal seizures, grand mal seizures, postictal depression, status epilepticus, and coma, with death 9 days after onset of the movement disorder. Bronchoalveolar carcinoma was widely disseminated in lungs and bones, and as three metastases in brain. Bland “ischemic” necrosis in a pseudolaminar pattern was present in the neocortex. Innumerable Cowdry type A intranuclear inclusion bodies were seen in neurons, astrocytes, and oligodendroglia. Immunofluorescence demonstrated Herpes simplex virus type 2 antigen and electron microscopy revealed virions with the morphology of the Herpes group. The case is significant for (1) the concurrence of intracranial metastases and Herpes simplex encephalitis, and (2) the causal agent, Herpes simplex virus type 2. The implication for the clinical neurocientist is the potential in a patient with systemic cancer, for the causation of neurologic complications by more than one factor or mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690552
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  • 20
    Electronic Resource
    Electronic Resource
    Pituitary adenomas secreting more than two hormones (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 67-72 
    Details
    ISSN: 1432-0533
    Keywords: Pituitary adenoma ; Ultrastructure ; Classitication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of pituitary adenoma secreting more than two hormones is presented. Morphological findings of this tumor have been correlated with biological behavior and with hormonal activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691794
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  • 21
    Electronic Resource
    Electronic Resource
    Herpes simplex virus (HSV) infection of organotypic nerve cell cultures (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 219-221 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex virus ; Organotypic nerve cell cultures ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In HSV-2 infected cultures, intranuclear tubule-like structures were found more commonly in fibroblasts and central nervous system (CNS) neurons than in oligodendrocytes, astrocytes, satellite and Schwann cells, but were found least often in peripheral neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690523
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  • 22
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    Electronic Resource
    Melanosis Cerebelli (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 215-220 
    Details
    ISSN: 1432-0533
    Keywords: Melanosis of the dentate nucleus ; Glial melanin ; Ultrastructure ; Intrared spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pigment present in melanosis cerebelli where it is deposited in the dentate nucleus and within the cerebellar granular layer is similar to that of S. nigra as judged from the typical infrared absorption bands near wave numbers 3.450 cm−1 and 1.650 cm−1, respectively. According to electron microscopic findings, this type of melanin arises within the astrocytes of the dentate nucleus. The astrocytic melanosomes exhibit a relatively monotonous substructure reaching diameters of 30 μ and more, and they differ in this respect from the triadic neuronal melanosomes of S. nigra that are strongly reminiscent of lipofuscin granules. These differences may be due to additional components of melanosomes, apparently specific of a particular cell type, and they are in turn accounted for by the dissimilar cellular metabolic make-up of nigral cells and astrocytes, respectively. This does not dismiss the possibility, however, that the melanin pigments of either type of melanosomes are the same or closely related to each other as far as their basic chemical composition is concerned. The cause of the melanosis of the dentate nucleus is not known. Possibly involutional tissue changes governed by endocrine factors among others may play an important part.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690847
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  • 23
    Electronic Resource
    Electronic Resource
    Becker's X-linked muscular dystrophy histological, enzyme-histochemical, and ultrastructural studies of two cases, originally reported by Becker (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 69-77 
    Details
    ISSN: 1432-0533
    Keywords: Muscular dystrophy ; Becker-type ; Benign X-linked ; Histopathology ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle biopsies of two patients originally reported in the Göttingen family by Becker (1962) that formed the basis of separating a benign X-linked muscular dystrophy from the rapidly progressive Duchenne-type X-linked muscular dystrophy, revealed mild pathological changes in the younger patient and more advanced in the older one, consisting of increased spectra of fiber diameters, endomysial fibrosis, angulated fibers, pyknotic nuclear clumps and small groups of atrophic fibers. Essentially, both biopsies showed the same changes, but of different severity, possibly due to the differences in age and muscle biopsy sites. These changes were regarded “myopathic”, but a neurogenic component was suggested. Our observations accord well with those of a larger series (Bradley et al., 1978) where both electromyography and histopathology revealed a mixed “myopathic-neurogenic pattern” in patients with Becker-type dystrophy. Differential diagnostic aspects encompass Duchenne's muscular dystrophy, the other hereditary dystrophies and X-linked proximal spinal muscular atrophies. The precise nature of Becker-type muscular dystrophy requires morphological data on peripheral nerves, spinal roots and spinal cord anterior horn cells as well as sequential biopsy analysis to substantiate the primary site of pathology. However, on the basis of available data, it seems reasonable to suggest that the early changes of degeneration/regeneration which are accompanied by a markedly elevated CPK eventuate in the histopathologic and electromyographic patterns illustrated in these two patients with Beckertype dystrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684807
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  • 24
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of in vitro grown cells from experimentally induced neurogenic tumors (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 61-66 
    Details
    ISSN: 1432-0533
    Keywords: Experimental tumors ; Tissue culture ; Scanning ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serially transplanted neurogenic tumors of experimental origin were explanted in vitro and analyzed by scanning electron microscopy. In explants of intracerebrally transplanted gliomas, small stellate cells with branching processes were observed; in transplanted tumors of the peripheral nervous system, slender bipolar cells as well as fibroblasts emerged. The stereoscopic features were compared with the picture of conventional light microscopy. The findings are consistent with the assumption of the glial derivation of CNS-tumors induced with neurotropic alkylating carcinogens. The peripheral tumors are composed of Schwann-cell like elements and fibroblasts. The significance of the results for the cytogenetic derivation of brain tumors are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698274
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  • 25
    Electronic Resource
    Electronic Resource
    A golgi and electron microscopic study of a dysplastic gangliocytoma of the cerebellum (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 163-165 
    Details
    ISSN: 1432-0533
    Keywords: Dysplastic gangliocytoma ; Cerebellum ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of a dysplastic gangliocytoma of the cerebellum is studied by means of the Golgi method and electron microscopic examination. Thick proximally unbranched dendrites with terminal arborizations and varicose influorescences in the form of a basket are stained with the Golgi method. Axons are always descendant to the inner myelinated layer of the redistributed cerebellar cortex, while ascendant collaterals are observed at the level of the outer myelinated layer. Clear and dense-core vesicles and synapses are common in the cellular profiles under electron microscopic examination. From these data and because of the lack of putative connections through the white matter, an organized, self-regulated, catecholamine-mediated complex may be postulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717043
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  • 26
    Electronic Resource
    Electronic Resource
    An ultrastructural study of the cerebrospinal fluid in visna (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 39-43 
    Details
    ISSN: 1432-0533
    Keywords: Visna ; Slow viral infection ; CSF ; Ultrastructure ; Myelin fractions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An electron microscopic examination was done on 8 samples of cerebrospinal fluid (CSF) from Icelandic sheep infected by the intracerebral route with visna virus. The specimens were collected 1 month, 2 months, and 4 years after infection. A differential cell count done on low-power electron micrographs showed that the cellular exudate was composed of mononuclear cells mainly macrophages and lymphocytes with a few plasma cells. Macrophages were with one exception more numerous than lymphocytes and an increased proportion of macrophages showed evidence of phagocytosis with time after infection. Reactive lymphocytes were in general more numerous than small lymphocytes. Various stages in the maturation of plasma cells were observed. The cellular composition in the CSF is compatible with the view that visna is an immunopathological process. Myelin figures and fragments of myelinated axons were observed in two specimens indicating an active myelin-breakdown. The possibility that escape of myelin into the CSF may lead to sensitization to myelin antigens and perpetuation of this chronic neurologic affection is discussed. Visna virions could not be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691789
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  • 27
    Electronic Resource
    Electronic Resource
    Pseudoviral hollow-cored vesicles in multiple sclerosis brain (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 63-66 
    Details
    ISSN: 1432-0533
    Keywords: Acute multiple sclerosis ; Virus-like particles ; Demyetination ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Novel, superficially ‘virus-like’ hollow-cored particles 50–60 nm in diameter were found in the perivascular extracellular space of the brain from a patient who died with acute multiple sclerosis (MS). It is concluded that they are not virions but are derived from myelin undergoing vesicular demyelination. This case demonstrates the need for caution in the interpretation of unusual electron microscopic appearances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691793
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  • 28
    Electronic Resource
    Electronic Resource
    Etude en microscopie electronique et neurochimique d'un cas de maladie d'Alexander (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 133-140 
    Details
    ISSN: 1432-0533
    Keywords: Alexander's disease ; Rosenthal's fibers ; Peripheral Nerve ; Electron microscopy ; Neurochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report the results of a cerebral and of a neuromuscular biopsies and of the autopsy findings in another infantile case of Alexander's disease in a girl. They review the 17 previously reported cases of this disease and the various etiopathogenic hypotheses mentioned. The presence of numerous, sometimes abnormal enlarged mitochondria and of abundant membranous cytoplasmic bodies in the astrocytic cytoplasm seems to be unreported elsewhere. Peripheral nerve changes are mentioned for the first time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691891
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  • 29
    Electronic Resource
    Electronic Resource
    Neuronal degeneration in the brain of the brindled mouse (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 17-25 
    Details
    ISSN: 1432-0533
    Keywords: Brindled mutant mouse ; Male hemizygotes ; Neuronal degeneration ; Ultrastructure ; Giant mitochondria ; Copper deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The brindled mouse (Mobr) is a neurological mutant mouse with clinical and biochemical features closely similar to Kinky hair syndrome (KHS) in humans. Neuronal degeneration in the cerebral cortex and thalamic nuclei was the constant neuropathological lesions in the CNS of the male hemizygotes of this mutant (Yajima and Suzuki, 1978). Ultrastructurally, many cortical neurons contained enlarged mitochondria with prominent tubular or vesicular cristae, which were similar to those described in the Purkinje cells in the human KHS (Ghatak et al., 1972) and in the rat brain with copper deficiency (Prohaska and Wells, 1975). Such mitochondria were observed not only in the degenerating neurons but even in the otherwise normal-appearing cortical neurons, suggesting that the mitochondrial damage possibly related to the deficient activities of the copper containing enzymes (cytochrome oxidase, etc.) preceded the neuronal degeneration. Many mitochondria in the severely degenerated neurons contained numerous electron dense spicules of possible calcium. Although rare, similar morphological alteration of neuronal mitochondria was also noted in the female heterozygotes, indicating the presence of possible subclinical defect in copper transport in the heterozygotes as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691800
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  • 30
    Electronic Resource
    Electronic Resource
    Primary rhabdomyosarcoma of the cerebrum (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 111-115 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumor ; Rhabdomyosarcoma ; Mesenchymal cell ; Myotube ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of primary cerebral rhabdomyosarcoma in a 51-year-old female is reported. The histogenesis of this tumor is discussed. The clinicopathological features of 10 previously reported similar tumors of the CNS are briefly reviewed. Histologically the tumor was polymorphic, but composed of poorly differentiated cells interpreted as rhabdomyoblasts without definite cross-striation. Electron microscopy established that the poorly differentiated cells were of rhabdomyosarcomatous nature, compatible with presumptive myoblasts and analogous to developing fetal muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691888
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  • 31
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    Electronic Resource
    A study of the perineurial diffusion barrier of a peripheral ganglion (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 139-144 
    Details
    ISSN: 1432-0533
    Keywords: Perineurium ; Peripheral ganglion ; Diffusion barrier ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The perineurial diffusion barrier to horseradish peroxidase (HRP) and ferritin was investigated in superior cervical ganglia of rats and mice. The ganglion was surrounded by a delicate epineurium and 2–5 perineurial lamellae joined by zonulae occludentes and desmosomes. Following local application of tracers the animals were killed after 5, 30, and 60 min and the distribution of HRP and ferritin was studied by light and electron microscopy. The inner layers of the ganglionic perineurium prevented diffusion of both HRP and ferritin into the endoneurium. Owing to the fewness of the perineurial lamellae investing the ganglion. HRP had often extended to the innermost lamella 60 min after application. HRP and ferritin were present in vesicles of ganglionic perineurial cells. There was no passage of tracers via intercellular junctions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684815
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  • 32
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    Electronic Resource
    An ultrastructural study of cultured human meningioma cells (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 11-15 
    Details
    ISSN: 1432-0533
    Keywords: Meningioma ; Cell culture ; Ultrastructure ; Cell junctions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural alterations in human meningioma cells grown in vitro are reported. In early passages the cells retain some of the characteristic features of the original tumors. These include interdigitations associated with intercellular junctional devices (e.g., desmosomes, gap junctions). However, with repeated subculture these features tend to be less frequent. Typical whorl formations are observed only in primary cultures. The nunber of cytoplasmic filaments, lipid inclusions and other dense bodies increases with time in culture. Cytoplasmic invaginations into nuclei and the appearance of very large cells become more frequent in repeatedly transferred cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684798
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  • 33
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    Electronic Resource
    The fine structure of cerebral capillaries in “overgrown” neural tissue (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 25-32 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral blood vessels ; “Overgrowth” ; Embryonic development ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebral capillaries in “overgrown” neural tissue of chick embryo brains ranging in age from 5–18 days of incubation were studied by means of electron microscopy. The vessels in the abnormal tissue showed more extensive and prolonged interdigitations and overlapping of adjacent endothelial cells than did those in normal control brains. In the abnormal neural tissue the appearance and distribution of endothelial cell organelles was similar to that in normal tissue; however, the Golgi complex was less highly developed, and there was an increased amount of coated vesicles in the capillaries of the abnormal brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684800
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  • 34
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    Electronic Resource
    Pathological alterations of ependyma and choroid plexus after experimental cerebral infection of mice with Sendai virus (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 85-94 
    Details
    ISSN: 1432-0533
    Keywords: Paramyxovirus infection ; Ependyma ; Choroid plexus ; Electron microscopy ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of intracerebral inoculation of Sendai virus into young adult mice were investigated by immunofluorescence, light, and electron microscopy. Immunofluorescence of virus-specific antigens was maximal on the third day after inoculation, revealing infection of leptomeninges, ependyma, and choroid plexus. Histologically, meningitis, ependymitis, and choroiditis occurred between the second and third days. The choroiditis was associated with formation of vacuoles within the cytoplasm of epithelial cells. The vacuoles reached diameters up to 50 μm. The ubiquitous vacuolization of plexus epithelia resulted in a honeycomb-like pattern. Opaque viral inclusions were visible within the cytoplasm of choroidal and ependymal epithelium as well as in mononuclear inflammatory cells. On electron microscopy, they were composed of intracytoplasmic nucleocapsid accumulations. Viria lay free between microvilli of plexus epithelial cells, and budding virus structures were observed at cellular surfaces. Occasionally, complete viria occurred in the cytoplasm of plexus epithelial cells and were surrounded by a unit membrane from which they appeared to arise by budding. The formation of this small cavity can be interpreted as the first stage of vacuole formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684809
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  • 35
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    Electronic Resource
    Etude quantitative et en microscopie electronique du nerf dans sept cas de neuropathie sensitive idiopathique sporadique (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 133-137 
    Details
    ISSN: 1432-0533
    Keywords: Sensory neuropathy ; Nerve biopsy ; Electron microscopy ; Quantitative study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An electron microscope study and quantitation of myelinated and unmyelinated fibers of seven nerve biopsies performed in sporadic cases of idiopathic sensory neuropathy is reported. The number of myelinated fibers is markedly decreased or absent in every case. On the contrary, the unmyelinated fiber numbers are normal or increased. In most cases, the small diameter myelinated and unmyelinated fibers proportions are higher than those of control biopsies. The electron microscope study discloses evidence of degeneration of Wallerian type and regeneration is also indicated by quantitative studies. Regenerative phenomena seem more obvious in sporadic cases than in previously reported studies of familial cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684814
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  • 36
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    Electronic Resource
    Growth hormone-producing pituitary adenoma with giant secretory granules (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 239-241 
    Details
    ISSN: 1432-0533
    Keywords: Acromegaly ; Electron microscopy ; Growth hormone ; Pituitary adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unusually large, oval and pleomorphic secretory granules were noted by electron microscopy in an acidophilic adenoma of the pituitary. The tumor, which was removed by surgery from a 42-year-old woman with elevated blood growth hormone levels and the clinical features of acromegaly, was found to contain growth hormone by the immunoperoxidase technique. This ultrastructural abnormality of secretory granules was not reported so far and was not seen among the 58 cases of growth hormone-producing adenomas investigated in our laboratory. The present case clearly shows that the cytogenesis and cellular composition of pituitary adenomas cannot be determined by solely examining the size and shape of secretory granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690852
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  • 37
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    Electronic Resource
    Studies on the early changes in acute isoniazid neuropathy in the rat (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 85-92 
    Details
    ISSN: 1432-0533
    Keywords: Isoniazid ; Neuropathy ; Intoxication ; Dying back ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Large single doses of isoniazid by mouth (1–2 g/kg) have been shown to produce in rats Wallerian degeneration visible with the light microscope from the third day onwards. By contrast, changes in axons are seen from 24 h onwards by electron microscopy. The earliest ultrastructural changes are associated with vacuoles appearing between axon and Schwann cells. These are large and focal, and often compress the axon. The adjacent axon may show changes in smooth ER, and in microtubular arrangement. Alterations in smooth membranes and in mitochondria are visible in Schwann cell cytoplasm, not necessarily related to the vacuole formation and axonal features. It is suggested that INH neuropathy is essentially a multifocal axonal lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717029
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  • 38
    Electronic Resource
    Electronic Resource
    Neurotoxicity of sodium cyanate (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 75-79 
    Details
    ISSN: 1432-0533
    Keywords: Neurotoxicity ; Cyanate ; Demyelination ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of sodium cyanate (NaNCO) on the nervous system of Maccaca nemestrina were studied at 2, 4, and 6 months of administration of the drug. The two groups injected with daily doses of 35 and 25 mg/kg/day of Na-cyanate developed a predominantly demyelinating lesion in the pyramidal tracts of the spinal cord. No neuronal changes were observed in the motor cortex, basal ganglia, midbrain, medulla or anterior horn cells of the spinal cord. There was no evidence of peripheral neuropathy. A comparison between the cyanate induced neuropathy in the rat and in the primate was drawn. Ultrastructurally, both species developed a demyelinating process of central or peripheral myelin characterized by vacuolation of the myelin sheath, removal of myelin debris by macrophages and re-myelination. There was little evidence of axoplasmic damage except for an occasional distended fiber containing abundant dense bodies and whorls of neurofilaments. Oligodendrocytes and Schwann cells were electron microscopically intact and participated actively in remyelination. Maccacas maintained at 15 mg/day and sham animals remained normal clinically and anatomically. The predominantly myelinotoxic effect of cyanate is similar to that produced by other myelinotoxic agents and is attributed to a selective modification of myelin proteins by carbamylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698277
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  • 39
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    Electronic Resource
    An electron microscopic study of childhood dermatomyositis (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 189-196 
    Details
    ISSN: 1432-0533
    Keywords: Childhood dermatomyositis ; Muscle biopsy ; Electron microscopy ; Tubular arrays
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle biopsies from 12 patients with a typical clinical picture of dermatomyositis have been examined by electron microscopy. Endothelial cells of intramuscular blood vessels, their basal lamina, pericytes, muscle fibers, and satellite cells show degenerative or regenerative alterations. In nine patients, tubular arrays were noted in the cisterns of endoplasmic reticulum of endothelial cells, pericytes, lymphocytes, macrophages and satellite cells. Other types of inclusions were also observed. The pathogenesis of the disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690546
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  • 40
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    Electronic Resource
    Morphological observations in the nervous system of prenatal mucopolysaccharidosis II (M. Hunter) (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 139-143 
    Details
    ISSN: 1432-0533
    Keywords: Mucopolysaccharidosis II ; Prenatal diagnosis ; Electron microscopy ; Lysosomal storage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light and electron microscopic findings in the nervous system of a 23-week-old fetus are reported, in which MPS II was diagnosed prenatally. The degrees of myelination and neuronal differentiation were similar as in a normal fetus of the same age. A storage of mucopolysaccharides in typical vacuolar inclusion bodies was present throughout the peripheral and central nervous system, mainly in cells of mesenchymal origin. “Zebra” bodies and granulo-membranous bodies, which are thought to represent secondary ganglioside accumulation were only found in the well developed neurons of the spinal cord and spinal ganglia, but not in the poorly developed neurons of the cerebellar and cerebral cortex. Mucopolysaccharide storage in endothelial cells of cerebral blood vessels precedes the appearance of lipid storage in cerebral neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691155
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  • 41
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    Electronic Resource
    Ultrastructural study of medullomyoblastoma (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 211-214 
    Details
    ISSN: 1432-0533
    Keywords: Medullomyoblastoma ; Desmoplastic medulloblastoma ; Teratoid ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of cerebellar medullomyoblastoma in a young boy was investigated by electron microscopy. The neuroectodermal component shows the characteristics of a desmoplastic medulloblastoma. The mesodermal component consists of more or less differentiated cross-striated muscle cells. Undifferentiated muscle cells are very similar to proliferated endothelial cells of blood vessels within the muscular component, so that an origin of this component from pluripotential endothelial cells of the vessel wall is suggested. This tumor is considered a malignant teratoid because of the derivation from two blastodermic layers and because of the midline localization in children suggesting a malformative origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690521
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  • 42
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    Electronic Resource
    Über Melanin und Melanosomen im ZNS im Vergleich zu extracerebralen Erscheinungsformen und synthetischem Melanin aus Dopamin und Serotonin (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 177-188 
    Details
    ISSN: 1432-0533
    Keywords: Melanin ; Melanosomes ; Ultrastructure ; Infrared spectrophotometry ; X-ray diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Melanosomes and isolated melanosomal fragments (melanin particles) originating from gangliocytes (substantia nigra), astroglia (melanosis cerebelli), and melanocytes (melanotic meningeoma; metastases of melanoblastoma; melanosis thalami of the goat) were compared with synthetic melanins prepared from dopamine and serotonin, respectively. Samples were examined by electron microscopy, X-ray diffraction analysis according to Debye-Scherrer and by infrared spectrophotometry, and the results were evaluated with regard to characteristic features as they may relate to specific cell types or chemical structures. On electron microscopy all three types of melanosomes could be differentiated unequivocally as could the two synthetic melanins. Thus, there were similarities between synthetic melanin from dopamine and the gliogenic melanins of the cerebellum; the synthetic melanin from serotonin resembled melanin of melanocytes. X-ray diffraction analysis yielded 2-4 Debye diffraction rings with all human and synthetic samples, suggesting short range orders between 3.8 to 5 Å the sample obtained from a goat with thalamic melanosis showed a specific reflex pattern. While diffraction patterns of some melanins were partially identical, in particular that of melanin from dopamine and melanin of substantia nigra and dentate nucleus, respectively, they were different for the various melanocytic melanins. Further investigations are required to determine whether these differences are due to disparities in basic chemical structures or conformations or else, to particular compositional features of the various types of melanocytes as they arise from benign or malignant tumors or a specific species. Infrared spectrophotometry at higher wave numbers revealed the well known patterns of melanins, which are not, however, very suitable, for their further differentiation. At lower wave numbers (‘fingerprinting’) melanin of substantia nigra and the glial melanin in melanosis cerebelli yielded additional absorption bands of identical configuration. In contrast to melanin from dopamine, melanin from serotonin exhibited a closely similar absorption pattern in this spectral range, suggesting that the neuroectodermal melanins may contain a component possibly arising from serotonin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690518
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  • 43
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    Electronic Resource
    Tight junctions in choroid plexus papillomas (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 159-160 
    Details
    ISSN: 1432-0533
    Keywords: Tight junction ; Choroid plexus papilloma ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four cases of choroid plexus papilloma (CPP) obtained at the time of surgical excision were examined by electron microscopy and compared with normal choroid plexus (CP) of mouse and chick. In apical tight junctions fusion of the two outer leaflets of the adjacent cytoplasmic membrane was verified as in CP. This fact suggests that there is a blood-CSF barrier not only in CP but also in CPP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691895
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  • 44
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    The central nervous system in canine giant axonal neuropathy (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 169-172 
    Details
    ISSN: 1432-0533
    Keywords: Giant axonal neuropathy ; CNS ; Dog ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathology of the central nervous system (CNS) in a dog with giant axonal neuropathy (GAN) is presented. Swollen axons containing excessive and disorganised neurofilaments were present in the spinal cord, mainly at the distal portions of long tracts. The fasciculus gracilis and dorsal spinocerebellar tracts were affected only in the rostral cervical cord while the lateral cortico spinal tract was principally involved in the lower thoracic and lumbar cord. Occasional swellings were also found in the central dorsal columns of the rostral lumbar segments and in the dorsal and intermediate grey matter. The nuclei gracilis and cuneatus, restiform body and ventral spinocerebellar tracts were all involved in the brain stem. Spheroids were seen in the white matter of the rostral cerebellar vermis and in the granule cell layer. The brachium of the superior colliculus contained swollen axons and the cortex was diffusely involved with spheroids. The distribution was of a distal axonopathy and the cortical changes provided an explanation for the abnormal EEG and mental retardation found in some human patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690839
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  • 45
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    Electronic Resource
    Fine structure of prolactin pituitary adenoma with special reference to annulate lamellae (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 163-166 
    Details
    ISSN: 1432-0533
    Keywords: Electron microscopy ; Pituitary adenoma ; Annulate lamellae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopy revealed the presence of annulate lamellae in the cytoplasm of a heavily granulated prolactin cell adenoma that had been removed from a 34-year-old male patient presenting impotence. To our knowledge this is the third case of pituitary adenomas where annulate lamellae are reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684820
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  • 46
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    Electronic Resource
    Paraganglioma in the cauda equina region (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 235-237 
    Details
    ISSN: 1432-0533
    Keywords: Paraganglioma ; Cauda equina region ; Neurosecretory granules ; Nerve fibers ; Endothelial cells ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Some new ultrastructural observations are documented in a paraganglioma in the cauda equina region. These include the presence of nerve fibers in the tumor capsule, clear vesicles and tubulo-vesicular structures in some cytoplasmic processes in the tumor, fenestrated endothelial cells, and numerous tubular bodies in some endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690851
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  • 47
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    Electronic Resource
    Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 27-30 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Neurofibrillary tangles ; Ultrastructure ; Straight tubule ; Twisted tubule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy. Straight tubules and twisted tubules were observed in both the cortical and subcortical neurofibrillary tangles. Most tubules appeared separately in each neuron but a few straight tubules were mixed with the twisted tubules in the cortical tangles. The implication and possible significance of this findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691787
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  • 48
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    The role of Schmidt-Lanterman incisures in Wallerian degeneration (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 95-103 
    Details
    ISSN: 1432-0533
    Keywords: Schmidt-Lanterman incisures ; Electron microscopy ; Nerve crush ; Wallerian degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopy of changes at Schmidt-Lanterman incisures in Wallerian degeneration has been described only briefly previously. We have demonstrated that the changes up to 36 h after nerve crush are chiefly peri-incisural. At 12h and 24h ‘incisural dilatation’ consisted of an intraperiod line separation of peri-incisural myelin lamellae, which began among inner (adaxonal) lamellae extending later to outer (abaxonal) lamellae. The incisure itself showed little or no change. At 36 h, ovoid formation was apparent in most fibres. The sites of fibre cleavage to form ovoids occurred adjacent to incisures at the focal regions of myelin lamellae separation. Even within ovoids the incisures themselves remained intact at 36 h. The fine structural changes at incisures following nerve crush provide an understanding of the increased perceptibility of incisures by light microscopy during early Wallerian degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691150
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  • 49
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    Complete cerebral ischemia (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 113-125 
    Details
    ISSN: 1432-0533
    Keywords: Complete cerebral ischemia ; Postischemic recirculation ; Electron microscopy ; Nuclear perturbations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal, astrocytic, and oligodendrocytic elements in several brain loci of the cat were examined at the light and electron microscopic level immediately after periods of complete cerebral ischemia (CCI) uncomplicated by post-ischemic recirculation. Such CCI episodes ranged from 1.5–25 min duration and were methodically produced in a cat model employing rigorous physiological controls. Subsequent to these CCI insults, morphological alterations occurred in a homogeneous manner within each cell type of all loci examined; however, variation in the temporal onset and magnitude of alterations among the various cell types was observed. With brief ischemic insults all cell nuclei demonstrated pronounced nuclear alterations, while their cytoplasmic organelles displayed minimal change. Chromatin clumping and nucleolar condensation were observed in both neurons and glia subsequent to 1.5–5 min of CCI, respectively. With increasing durations of CCI such changes were more dramatic and conspicuous alterations of the cytoplasmic organelles were observed. On the basis of extensive morphological analyses the present study illustrates that nuclear alterations are the first to occur subsequent to CCI. The homogeneity of neuronal involvement seen subsequent to CCI uncomplicated by post-ischemic recirculation is inconsistent with the “selective vulnerability” purported to occur by others. The significance of this inconsistency remains to be assessed; yet, the suggestion is advanced that post-ischemic recirculation may be a factor in the genesis of such vulnerability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691152
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  • 50
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    Electronic Resource
    Tumorigenic clones of hamster brain cells transformed in vitro by polyoma virus (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 189-197 
    Details
    ISSN: 1432-0533
    Keywords: Hamster brain cells ; Polyoma virus ; Tumorigenicity ; Ultrastructure ; Specific nervous proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphological characteristics of three clones of hamster brain cells transformed in vitro by polyoma virus and of the tumors obtained after subcutaneous grafting of these cells in syngenic animals are reported. These clones appeared to be glial in nature by light and electron microscopy. The initial tumors induced by the three clones presented astrocytic features both by electron microscopy and immunohistochemistry. Analysis of the subsequent in vivo passages showed a decrease in cell differentiation, which was accompanied by a decrease in the latency period; after 2 years of serial transplantation, the tumors seemed poorly differentiated gliomas. A control cell line of hamster cerebellar cells evolved similarly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690519
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  • 51
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    Licht- und elektronenmikroskopische sowie cytometrische Untersuchungen an peripheren Nerven beim Morbus Tangier (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 53-59 
    Details
    ISSN: 1432-0533
    Keywords: Tangier disease ; Peripheral nerve ; Electron microscopy ; Cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A sural nerve biopsy was performed in a 55-year-old male patient with Tangier disease (familiallipoprotein deficiency). Light-microscopy showed an increase in the endoneural connective tissue and a loss of nerve fibers indicating a chronic peripheral neuropathy. Electron-microscopy revealed an accumulation of lipid droplets within Schwann cells of myelinated and unmyelinated nerve fibers. When compared with age-matched controls the myelinated fiber density was reduced with a relative preponderance of small myelinated fibers. In addition, distributional cytometric studies of nerve vibers in relation to the perineurium and endoneurial capillaries showed: Contrary to 4.6–7.5 μm thick nerve fibers, which accumulated in the center of the nerve fascicle, small (0.5–4.5 μm) and large (7.6–10.0 μm) fibers lay nearby the perineurium. The measured increase in small myelinated nerve fibers around endoneurial capillaries may be explained as a sign of regeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691805
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  • 52
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    Early events in canine distemper demyelinating encephalomyelitis (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 1-10 
    Details
    ISSN: 1432-0533
    Keywords: Dog ; Canine distemper virus ; Cell fusion ; Demyelination ; Encephalomyelitis ; Immunofluorescence ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The early neuropathological development of demyelinating Canine Distemper Encephalomyelitis (CDE) was studied in SPF dogs. Neural tissues were examined up to 30 days post infection (PI). Three phases of activity were observed. The primary event (first observed 8 days PI) was a nonsuppurative encephalomyelitis associated with the initiation of central nervous system (CNS) infection by virus-laden lymphocytes. At 24 days PI noninflammatory demyelination occurred in well defined, subependymal foci. Cell fusion and syncytia formation accompanied this early demyelination. The third phase, found at day 30 PI in one dog showing signs of recovery, was a second wave of nonsuppurative inflammation. The initial encephalomyelitis was widely disseminated throughout the CNS but subsequent demyelination appeared to be initiated from within the ventricular system. Myelin was phagocytosed by endogeneous CNS macrophages often infected with Canine Distemper Virus (CDV). The possible importance of viral induced cell fusion as well as immune factors in the mechanism of demyelination are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684797
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  • 53
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    Aufbau und Funktion von biologischen Membranen (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 641-646 
    Details
    ISSN: 1432-1440
    Keywords: Mitochondria ; Membranes ; Cytochrome oxidase ; Fluorescence methods ; Electron microscopy ; Mitochondrien ; Membranen ; Cytochromoxidase ; Fluoreszenzmethoden ; Elektronenmikroskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Biologische Membranen sind im wesentlichen asymmetrische zwei-dimensionale Lösungen von Proteinen in einer bimolekularen Lipidschicht. Das allgemeine Aufbauprinzip und viele physikalische Eigenschaften biologischer Membranen lassen sich dadurch erklären, daß sowohl die Membranproteine als auch die Membranlipide hydrophile und hydrophobe Stellen besitzen. Die meisten biologischen Eigenschaften einer Membran werden durch die Membranproteine bestimmt, die richtungsgebundene Prozesse katalysieren können. Anhand des Membranproteins Cytochromoxidase wird gezeigt, wie die räumliche Anordnung von Membranproteinen durch chemische, fluorometrische und elektronenoptische Methoden studiert werden kann. In den meisten Fällen ist es allerdings heute noch nicht möglich, die Funktionen einer Membran aufgrund ihres molekularen Bauprinzips zu erklären.
    Notes: Summary Biological membranes are essentially asymmetric two-dimensional solutions of proteins in a bimolecular lipid layer. The overall structure and many physical properties of biological membranes can be explained by the fact that membrane proteins and membrane lipids contain hydrophilic as well as hydrophobic domains. Most biological properties of the membrane are determined by the membrane proteins which can catalyze directional processes. With the membrane protein cytochrome oxidase it will be demonstrated how the three-dimensional arrangement of membrane proteins can be studied by chemical, fluorometric, and electron optical methods. However, it is in most cases still impossible to explain the function of a membrane on the basis of its molecular architecture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477631
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  • 54
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    Electronic Resource
    DNA of free and complexed origin in human plasma: Concentration and length distribution (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 451-456 
    Details
    ISSN: 1432-1440
    Keywords: Menschliches Plasma ; DNS ; Elektronenmikroskopie ; Konzentration ; Human plasma ; DNA ; Electron microscopy ; Concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The DNA content in plasma of five healthy human individuals has been estimated. Structures ascertained by electron microscopy have been identified as double-stranded DNA. Depending on the isolation procedure applied the DNA molecules found may originate from free and/or complexed forms of DNA. The lengths range from less than 0.2 µm up to about 13 µm. DNA concentration is in the range of 3 to 11 ng/ml.
    Notes: Zusammenfassung Es wurde der DNS-Gehalt im Plasma fünf gesunder Testpersonen ermittelt. Elektronenmikroskopisch darstellbare Strukturen konnten als doppelsträngige DNS charakterisiert werden. Bedingt durch die Isolierungsmethode resultiert die gefundene DNS sowohl von freier und/oder DNS, die in komplexierter Form im Plasma vorliegt. Die Moleküllängen variieren von weniger als 0,2 µm bis zu ca. 13 µm. Die Konzentration liegt im Bereich von 3–11 ng DNS/ml.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477498
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  • 55
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    Electronic Resource
    R-Bodies in newly isolated free-living hydrogen-oxidizing bacteria (1979)
    Springer
    Archives of microbiology 121 (1979), S. 9-15 
    Details
    ISSN: 1432-072X
    Keywords: R-Bodies ; Kappa particles ; Free-living hydrogen bacteria ; Induction ; Electron microscopy ; Chemical composition ; Defective prophages ; Plasmids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract R-Bodies have been found in a recently isolated pseudomonas-like free-living hydrogen oxidizing bacterium. Their isolation, fine structure and chemical composition are described and compared with the R-bodies from the kappa particles (Caedobacter), obligate endosymbionts of Paramecium aurelia. The 2K 1 R-bodies exhibited essential characteristics of the kappa R-bodies; however, their size and some other structural aspects proved that they represent a new type of R-bodies. The presence of phage tail-like particles in cells induced with Mitomycin C is in favour of the hypothesis that the R-bodies might be coded by defective prophages, or by extrachromosomal elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409199
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  • 56
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    Electronic Resource
    Acetobacter bacteriophage A-1 (1979)
    Springer
    Archives of microbiology 121 (1979), S. 193-197 
    Details
    ISSN: 1432-072X
    Keywords: Acetobacter suboxydans ; Bacteriophage A-1 ; Restriction ; Modification ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A bacteriophage ofAcetobacter suboxydans was isolated and found to correspond to type A phage according to Bradley's classification. The phage contains double stranded DNA. The length of the latency period and burst size could not be precisely determined because of apparent non-synchronous release of phage from single infective cycles. The host range was determined using 24 strains ofAcetobacter andGluconobacter species. Evidence for a probable occurence of host determined restriction and modification was obtained withAcetobacter suboxydans strain ATCC 621. The phage is designated A-1 and it is the first one to be reported forAcetobacter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689986
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  • 57
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    Electronic Resource
    The cell cycle of Bacillus subtilis as studied by electron microscopy (1979)
    Springer
    Archives of microbiology 123 (1979), S. 173-181 
    Details
    ISSN: 1432-072X
    Keywords: Bacillus subtilis ; Cell cycle ; DNA replication ; Cell division ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Bacillus subtilis strain Marburg was grown exponentially with a doubling time of 65 min. To follow the time course of various cell cycle events, cells were collected by agar filtration and were then classified according to length. The DNA replication cycle was determined by a quantitative analysis of radioautograms of tritiated thymidine pulse labeled cells. The DNA replication period was found to be 45 min. This period is preceded and followed by periods without DNA synthesis of about 10 min. The morphology and segregation of nucleoplasmic bodies was studied in thin sections. B. subtilis contains two sets of genomes. DNA replication and DNA segregation seem to go hand in hand and DNA segregation is completed shortly after termination of DNA replication. Cell division and cell separation were investigated in whole mount preparations (agar filtration) and in thin sections. Cell division starts about 20 min after cell birth; cell separation starts at about 45 min and before completion of the septum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446817
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  • 58
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    Electron microscopic study on the quaternary structure of the isolated particulate alcohol-acetaldehyde dehydrogenase complex and on its identity with the polygonal bodies of Clostridium kluyveri (1979)
    Springer
    Archives of microbiology 120 (1979), S. 255-262 
    Details
    ISSN: 1432-072X
    Keywords: Alcohol dehydrogenase ; Acetaldehyde dehydrogenase ; Clostridium kluyveri ; Electron microscopy ; Polygonal bodies ; Enzyme complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The alcohol-acetaldehyde dehydrogenase complex of Clostridium kluyveri has been separated from contaminating β-hydroxybutyryl-CoA dehydrogenase by repeated precipitation with manganese and ammonium sulfate. Mn++ was required for maximum alcohol dehydrogenase activity. The molecular weight of the enzyme complex was 194,000 as determined by sucrose density gradient centrifugation. The enzyme complex has been shown to contain two types of subunits with molecular weights of 55,000±2,600 and 42,000±1,200, respectively which are arranged in “H”-shaped particles. In solutions with an ionic strength above 25 mM the enzyme complex precipitated in the form of lumps as has been shown with specific ferritin-conjugated antibodies. These lumps are assumed to be aggregated polygonal bodies present in C. kluyveri.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423073
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  • 59
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    Electronic Resource
    Capnocytophaga: New genus of Gram-negative gliding bacteria. II. Morphology and ultrastructure (1979)
    Springer
    Archives of microbiology 122 (1979), S. 17-27 
    Details
    ISSN: 1432-072X
    Keywords: Gliding bacteria ; CO2-requiring ; Periodontal disease ; Gram-negative ; Ultrastructure ; Capnocytophaga
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Gram-negative, anaerobic gliding bacteria were isolated from normal supragingival plaque and from periodontal lesions. Isolates could be divided into two size classes: small 2.4–4.2 μm×0.38–0.5 μm and large 4.8–5.8 μm×0.42–0.6 μm cells. The outer membrane was either loose-fitting and wavy, or taut, and of variable thickness. An electron-dense fuzz was discernible on several of the isolates. The periplasmic region was of variable electron-density. The genus Capnocytophaga has been proposed for these organisms based on morphological and cultural characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408041
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  • 60
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    Electronic Resource
    A comparative ultrastructural study of the ascospores of some Saccharomyces and Kluyveromyces species (1979)
    Springer
    Archives of microbiology 121 (1979), S. 53-59 
    Details
    ISSN: 1432-072X
    Keywords: Saccharomyces ; Kluyveromyces ; Ultrastructure ; Ascospore wall ; Taxonomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Three types of structure of the ascospore wall were found among the haploid Saccharomyces species examined: a warty wall (S. rouxii), a smooth wall with a single electron-light inner layer (S. bailii) and a smooth wall with a double light inner layer (S. montanus, S. florentinus). The latter type also occurred in Kluyveromyces thermotolerans and K. waltii. In K. fragilis spores the wall had a single light inner layer. The taxonomic implications of these findings were discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409205
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  • 61
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    Bdellovibrio-like parasite of cyanobacteria symbiotic in marine sponges (1979)
    Springer
    Archives of microbiology 123 (1979), S. 101-103 
    Details
    ISSN: 1432-072X
    Keywords: Bdellovibrio ; Cyanobacteria ; Marine sponges ; Symbiosis ; Infection ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A bdellovibrio-like bacterium was observed infecting unicellular symbiotic cyanobacteria in two coral reef sponges, Neofibularia irata and Jaspis stellifera. The infecting bacterium, which was located between the cell wall and the cytoplasmic membrane of the cyanobacteria, was similar in size and appearance to previously described bdellovibrios. This observation is believed to extend the host range of the bdellovibrios.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403507
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  • 62
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    Methanogenium, a new genus of marine methanogenic bacteria, and characterization ofMethanogenium cariaci sp. nov. andMethanogenium marisnigri sp. nov. (1979)
    Springer
    Archives of microbiology 121 (1979), S. 147-153 
    Details
    ISSN: 1432-072X
    Keywords: Methanogenium cariaci ; Methanogenium marisnigri ; Marine methanogenic bacteria ; Ultrastructure ; TaxonomyMethanogenium gen. nov.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A new genus of marine methanogenic bacteria and two species within this genus are described.Methanogenium is the proposed genus andMethanogenium cariaci the type species. Cells of the type species are Gram-negative, peritrichously flagellated, irregular cocci with a periodic wall surface pattern. Colonies formed by these bacteria are yellow, circular and umbonate with entire edges. The DNA base composition is 52 mol% guanine plus cytosine. Formate or hydrogen and carbon dioxide serve as substrates for growth. Cells ofMethanogenium marisnigri are of similar shape but smaller diameter thanM. cariaci. The colonies ofM. marisnigri are convex, and the DNA base composition is 61 mol % G+C. Formate or hydrogen and carbon dioxide are growth substrates. Sodium chloride is required for growth of both methanogens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689979
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  • 63
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    The fine structure of neurones and cellular relationships in the abducens nucleus in the cat (1979)
    Springer
    Experimental brain research 35 (1979), S. 249-267 
    Details
    ISSN: 1432-1106
    Keywords: Abducens nucleus (cat) ; Peroxidase ; Neurones ; Synapses ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light and electron microscope studies of the abducens nucleus in the cat have disclosed two populations of neurones: large neurones 25 to 75 μm in diameter and small neurones 10 to 25 μm in diameter. Characteristic of the large neurones are a highly developed granular endoplasmic reticulum and a large number of axo-somatic synapses. The small neurones have a poorly developed granular endoplasmic reticulum and comparative by few axo-somatic synapses. Injection of horseradish peroxidase (HRP) into the ipsilateral lateral rectus muscle has been used to identify abducens motoneurones which represent 65% of the total number of cells in the abducens nucleus and form part of the large cell population. The remaining unlabelled large neurones (30% of the large cell population) probably represent motoneurones of the retractor bulbi muscles, abducens motoneurones which have failed to transport the HRP, and possibly internuclear neurones. The small neurones (5% of the total cell population) were never labelled by HRP. Axo-somatic and axo-dendritic synapses are numerous. Many of the synaptic terminals form contacts with two or more different postsynaptic elements. Axo-axonic synapses and synapses on the initial segments of large neurones are also present. Nodal synapses and branching of myelinated axons are common findings. Finally, extended areas of close apposition between dendritic membranes are frequently observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236614
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  • 64
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    Identification and distribution of the spinal and hypophyseal projection neurons in the paraventricular nucleus of the rat. A light and electron microscopic study with the horseradish peroxidase method (1979)
    Springer
    Experimental brain research 35 (1979), S. 315-331 
    Details
    ISSN: 1432-1106
    Keywords: Hypothalamic paraventricular nucleus ; Spinal projection neuron ; Hypophyseal projection neuron ; Horseradish peroxidase ; Electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of labeled neurons in the paraventricular nucleus of the hypothalamus (PVN) was studied following injections of horseradish peroxidase (HRP) into the spinal cord (C8 to T1) or the hypophysis in the rat. Injections were also made in the spinal cord in another group of animals, which were subjected to water deprivation for a period of 3 days, and the PVN of these animals was examined with the electron microscope. Spinal projection neurons (paraventriculospinal tract, PVST, neurons) formed two groups; the dorsal and the ventral groups. They were located within the parvocellular part of the PVN and fused into one at the caudal level. The neurons of the dorsal group were well assembled whereas those of the ventral group were intermingled with paraventriculohypophyseal tract (PVHT) neurons, which were concentrated in the magnocellular part. Electron microscopic observations revealed that HRP-labeled neurons after spinal injections did not contain neurosecretory granules and that they were not affected by water deprivation. On the other hand, neurons containing a number of neurosecretory granules displayed a significant degree of dilatation of the endoplasmic reticulum as the result of water deprivation. These neurons contained no HRP granules. The present findings suggest that the PVST neurons are distinct from the PVHT neurons and that the neuronal groups of both systems form different cell columns within the nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236618
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    Intrahypothalamic connections: An electron microscopic study in the rat (1979)
    Springer
    Experimental brain research 34 (1979), S. 201-215 
    Details
    ISSN: 1432-1106
    Keywords: Intrahypothalamic connections ; Deafferentation ; Electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Terminal degeneration within the hypothalamus was studied by electron microscopy 1 or 2 days (1) after carefully placed microlesions in the arcuate, anterior periventricular, ventromedial, premammillary and posterior hypothalamic nuclei and (2) after microlesions placed in the hypothalamus deafferented 3 weeks earlier. In the median eminence terminal degeneration was found after each of these lesions. Projections from the ventromedial nucleus reach the arcuate, suprachiasmatic, and anterior periventricular nuclei. Projections from the arcuate nucleus terminate in the medial preoptic, anterior periventricular, and ventromedial nuclei. After lesioning the premammillary nuclei degeneration was found in the supraoptic, arcuate, anterior hypothalamic and ventromedial nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235668
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    Ultrastructural data, with special reference to bouton/glial relationships, from the hypoglossal nucleus after a second axotomy of the hypoglossal nerve (1979)
    Springer
    Experimental brain research 36 (1979), S. 107-118 
    Details
    ISSN: 1432-1106
    Keywords: Rat ; Hypoglossal nucleus ; Ultrastructure ; Second axotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The left hypoglossal nerve of adult male albino rats was prevented from regenerating to the tongue after a distal axotomy by implanting the proximal stump into normally innervated left sternomastoid muscle. Eighty-four days after implantation, the hypoglossal nerve was transected again and its regeneration to the tongue unimpeded. From 8 to 70 days after this second axotomy the left hypoglossal nuclei were processed for quantitative ultrastructural analysis. The first aim of this study was to compare regeneration success in the hypoglossal nucleus after second axotomy with that accompanying outgrowth of the hypoglossal nerve into denervated sternomastoid muscle. During quantitative analysis a second aim developed, of elucidating bouton/glial relationships. The second axotomy induced loss and return of subsurface cisterns, dispersal and reassembly of Nissl substance, increase and decrease of microglial numbers, slight further loss and partial return of boutons with clear spherical vesicles and symmetrical synapses, slight increase and decrease of boutons with clear flat vesicles and symmetrical synapses, regrowth of retracted dendrites and restoration of their synapses, and gradual diminution of numbers of electron-dense neurones and dendrites. Astrocytes remained hypertrophied throughout. When compared with events in the hypoglossal nucleus accompanying innervation of denervated sternomastoid muscle by the hypoglossal nerve, the results suggest (1) that regeneration of the hypoglossal nerve to its own tongue muscle instead of to a foreign muscle caused no acceleration of recovery in the hypoglossal nucleus, and (2) that the microglial response is dependent on nerve integrity and not on bouton behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238471
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  • 67
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    Time-related changes in the ultrastructure of osteoclasts after injection of parathyroid hormone in young rats (1979)
    Springer
    Calcified tissue international 27 (1979), S. 129-135 
    Details
    ISSN: 1432-0827
    Keywords: Parathyroid hormone ; Osteoclasts ; Electron microscopy ; Morphometry ; Metaphysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effects of parathyroid hormone (PTH) on the size of the osteoclasts, nuclei, ruffled borders, and clear zones in long bones of thyroparathyroidectomized (TPTX) rats were quantitated as a function of time. These data were compared with the number of osteoclasts in the bone and with plasma calcium levels. A significant increase in the average size of the ruffled borders was demonstrated 30 min after injection of 50 U of purified bovine PTH, and of the clear zones 30–90 min after PTH. This was followed at 90 min by an increase in the average size of the cells. The sizes of ruffled borders and clear zones dropped sharply to control levels after 6 h, whereas the size of the cells remained elevated up to 12 h and returned to control values at 24 h. Plasma calcium levels were increased, but not significantly, between 30 min and 6 h. An increase in the number of osteoclasts was significant after 12 h. Removal of the parathyroid glands did not diminish the normal activity of osteoclasts. In animals with intact glands injection of 50 U of PTH did not cause a significant change in cell size or resorbing apparatus. It is concluded that PTH acts to rapidly stimulate the bone resorptive activity of osteoclasts and to cause a delayed increase in their number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441175
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  • 68
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    Ultrastructural evidence of myofibroblasts in pseudomalignant myositis ossificans (1979)
    Springer
    Virchows Archiv 381 (1979), S. 189-203 
    Details
    ISSN: 1432-2307
    Keywords: Pseudomalignant ossifying myositis ; Ultrastructure ; Myofibroblasts ; Macrophages ; Pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven cases of pseudomalignant ossifying myositis with a typical clinical symptomatology have been reported. None of the cases had experienced an injury. All the lesions were intramuscular and all of them showed a zonal arrangement. Electron microscopy in three cases allowed the demonstration of cells showing morphological features of myofibroblasts and monocytic cells of the macrophage type. These previously unreported features together with the zonal pattern of the lesions indicate their reparative nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257884
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  • 69
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    Muscle spindles in rheumatoid arthritis (1979)
    Springer
    Virchows Archiv 382 (1979), S. 191-200 
    Details
    ISSN: 1432-2307
    Keywords: Rheumatoid arthritis ; Muscle spindles ; Neuromuscular spindles ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102874
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  • 70
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    Ultrastructure of clear cell carcinoma of the ovary (1979)
    Springer
    Virchows Archiv 385 (1979), S. 77-91 
    Details
    ISSN: 1432-2307
    Keywords: Ultrastructure ; Ovary ; Clear cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structure of an ovarian clear cell carcinoma in a 65 year old woman was analysed. The tumor cells were of both clear and “hobnail” types. Both were characterized by the presence of short microvilli, abundant glycogen granules, a well-developed granular endoplasmic reticulum and Golgi apparatus, scanty lysosomes and very few lipid bodies. The tubules and gland-like spaces were always separated from the stroma by a basement membrane. At ultrastructural level the tumor cells do not resemble at all those of clear cell renal carcinomas. On the other hand, their submicroscopic features are strongly similar to those of the clear cell tumors found elsewhere in the female genital tract, emphasizing therewith their very probable müllerian origin. It is recommended to eliminate the term “mesonephroma ovarii” to designate the clear cell carcinomas of the ovary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433543
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  • 71
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    Liposarcoma of the breast (1979)
    Springer
    Virchows Archiv 385 (1979), S. 117-124 
    Details
    ISSN: 1432-2307
    Keywords: Liposarcoma ; Breast ; Histopathology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of primary liposarcoma of the breast in a 65-years-old woman is described by light- and electron microscopy. The patient had previously had a cystosarcoma phyllodes removed from the same area. A review of the literature showed 34 previously published cases of liposarcoma of the breast, which regarding age distribution, histological type and pattern of metastasis corresponded to liposarcomas of the lower limbs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433547
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  • 72
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    Untersuchungen zur Ultrastruktur der transitionalen cloacogenen Carcinome der recto-analen Grenzregion (1979)
    Springer
    Virchows Archiv 381 (1979), S. 223-239 
    Details
    ISSN: 1432-2307
    Keywords: Cloacogenic carcinomas ; Ano-rectal region ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical and pathological features of four transitional cloacogenic carcinomas (TCC) are presented with particular reference to electron microscopy. The incidence of this tumour is 1.4% of all ano-rectal neoplasms. Three cases showed a gross appearance similar to the common rectal neoplasms. One tumour presented without an intraluminal lesion, but infiltrated the bowel wall and the anal glands. TCC show a distinct histological pattern. The degree of differentiation of the basic transitional cell component determines the “grading” of the lesion. We distinguish between grade I, II and III. Grade I lesions show uniform polygonal cells with only occasional mitotic figures. There is distinct palisading of the nuclei of the peripheral tumour cell layers. Grade II lesions are characterized by partial or total loss of the peripheral palisading. Grade III lesions are extremely anaplastic (“oat cell” carcinoma). This histological classification correlates well with the prognosis. Electron microscopic investigation of TCC revealed the ultrastructural features of basal cells. The uniform tumour cells with large nuclei contain tonofibrils, desmosomes and hemi-desmosomes, free ribosomes, and relatively few other organelles. We did not find keratinocytes or keratohyalin granules in these four cases of TCC. It is emphasized that TCC of the ano-rectal region differ fundamentally from the basalcell carcinomas of the skin in their biological behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257887
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    Ultrastructural and histological study of 11 bronchial carcinoids (1979)
    Springer
    Virchows Archiv 381 (1979), S. 313-329 
    Details
    ISSN: 1432-2307
    Keywords: Bronchial carcinoids ; Different types ; Cells of origin ; Ultrastructure ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven of eleven bronchial carcinoids investigated showed cells with small granules resembling P cells which have already been described in human fetal and adult lung; two of these P cell tumours showed distinctive paraganglioid features. One tumour showed peculiar ultrastructural findings resembling closely those previously reported by Black (1969) in a so called “pulmonary oncocytoma”. Three remaining cases showed large secretory granules resembling those of type 3 cells already described by Hage (1973 b) in bronchial carcinoids; one of these tumours produced large amounts of 5-hydroxytryptamine (5HT). It is concluded that, on cytological grounds, at least two types of tumours can be distinguished among bronchial carcinoids, i.e. P cell and type 3 cell tumours. Moreover, two varieties of P cell carcinoids have been recognized, showing either the less frequent and more distinctive paraganglioid structure or the more common trabecular structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432474
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    Sclerosing angioma of the lung (1979)
    Springer
    Virchows Archiv 385 (1979), S. 93-101 
    Details
    ISSN: 1432-2307
    Keywords: Angioma ; Lung ; Carcinoma ; Pneumocytes ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Elektronenmikroskopische Untersuchung eines sog. sklerosierenden Hämangioms der Lunge, das im Oberlappen einer 32jährigen Frau zufällig entdeckt wurde. Der seltene gutartige Tumor, der lichtmikroskopisch wegen seines Gefäßreichtums an ein Hämangiom erinnert, zeigt elektronenmikroskopisch eine eindeutige epitheliale Struktur. Die Geschwulst entwickelt sich möglicherweise aus unreifen Pneumocyten. Histogenese sowie differential-diagnostische Probleme (Verwechslungsmöglichkeit mit Carcinom) werden diskutiert.
    Notes: Summary Electron microscopy of a sclerosing angioma of the lung, a coincidental finding in the upper lobe of a 32-year-old woman. The rare, benign tumor, whose vascular proliferation by light microscopy is reminiscent of an angioma, exhibits a clear epithelial structure by electron microscopy. The tumor may develop out of immature pneumocytes. The paper discusses histogenesis and problems of differential diagnosis (potential confusion with carcinomas).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433544
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    The ultrastructure of myxofibrosarcoma (1979)
    Springer
    Virchows Archiv 381 (1979), S. 121-139 
    Details
    ISSN: 1432-2307
    Keywords: Myxofibrosarcoma ; Fibroblast ; Histiocyte ; Myofibroblast ; Sarcoma ; Soft tissue tumour ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study of 11 myxofibrosarcomas is presented. The tumours were graded light-microscopically on a four-point scale according to cellularity, cell atypia and mitotic activity, as described in a previous paper: 3 were grade I, 2 grade II, 4 grade III and 2 grade IV. Fibroblast-like and myofibroblast-like cells predominated in the grade I and II tumours, while histiocyte-like cells were relatively few; in grade III and IV tumours histiocyte-like cells predominated. The fibroblast-like cells were spindle-shaped with fairly smoothly outlined nuclei, and contained abundant parallel membranes and wide cisternae of endoplasmic reticulum. The histocyte-like cells were irregular in shape and showed indented nuclei with large nucleoli and coarse, peripherally arranged clumps of heterochromatin. The cytoplasm of these cells showed prominent pseudopodiae, microvillous projections, conspicuous systems of vesicles and vacuoles, inclusions of lipid and pigment, numerous lysosomal structures and large digestive vacuoles indicating auto- and exophagocytosis. The myofibroblast-like cells showed abundance of parallelly arranged cytoplasmic microfilaments with dense body-like structures and condensation at the plasmic membrane. Occasional cells appeared to be intermediate forms and primitive looking, undifferentiated cells were also encountered. A few multinucleated tumours cells were seen in the grade IV tumours. Thus, the present study shows the composite fibroblastic, myofibroblastic and histiocytic character of the tumour cells of myxofibrosarcoma; the grade III and IV tumours, with a tendency to contain solid areas, seem to be closely related to the pleomorphic type of malignant fibrous histiocytoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257879
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    Giant cell tumor of bone (1979)
    Springer
    Virchows Archiv 381 (1979), S. 159-178 
    Details
    ISSN: 1432-2307
    Keywords: Giant cell tumor ; Ultrastructure ; Acid phosphatase ; Lysosomes ; Bone tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven benign giant cell tumors of bone were studied in the electron microscope, and the fine structural localization of acid phosphatase was elucidated. Three distinct cell types are always present in these tumors: stromal cells type 1; stromal cells type 2; and multinucleated giant cells. Small mononuclear cells may also occur, but are not likely to be actively participating in the neoplastic process. The range of variability in the fine structure of the different cell types constituting this tumor has been established. Variations in appearances include: a) presence of nuclear pseudoinclusions in stromal cells type 1 and multinucleated giant cells; b) aberrations in the structure of the rough surfaced endoplasmic reticulum in the same cell types; c) occurrence of ruffled borders, ectoplasmic layers and cytoplasmic labyrinths containing acid phosphatase in the giant cells. Some giant cells show evidence of marked phagocytic activity and contain large and numerous residual bodies carrying acid phosphatase. The significance of the interrelations between the different cell types are discussed and the possible role of stromal cells type 2 in immunological mechanisms directed against the tumor cells are mentioned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257881
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  • 77
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    Functions of different receptor systems in the reptilian labyrinth (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 31-35 
    Details
    ISSN: 1434-4726
    Keywords: Intracellular potentials ; Ultrastructure ; Hair cells ; Labyrinth receptors ; Reptilia (Crocodilia, Gekkonidae)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different biopotentials, following a mechanical stimulus, were recorded from single hair cells of the reptilian labyrinth, with electronoptically circumscript localizations: 1. From the apical cell pole, the receptor potential, intracellular or from the ciliary surface, within the physiological range proportional to stimulus amplitude, frequency or phase, without delay, and with no real threshold of mechanosensitivity, as measured by ciliary displacement amplitude or velocity. 2. From the synaptic zone, in the basal region of the hair cell, or from contacting nerve endings, the synaptic potentials, local excitatory or inhibitory processes, respectively, with measurable latencies and with non-linear distortion. 3. From the (dendritic) endings of the first afferent neuron (or neurons), spike-shaped action potentials, synchronized by the (excitatory) synaptic potentials. Characteristic curves were plotted as a quantitative representation of the mechano-electric input-output relations of the different types of hair cells. For proceeding morphological and physiological system analysis, the comparison of the different submammalian inner-ear receptor systems gives us some new possibilities of a closer correlation between ultrastructure and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455221
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    Adrenergic innervation of the eighth nerve and vestibular end organs in man (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 17-23 
    Details
    ISSN: 1434-4726
    Keywords: Eighth nerve ; Inner ear ; Human ; Fluorescence microscopy ; Electron microscopy ; Menière ; Neurilemoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fluorescence microscopy was used to examine the adrenergic, bloodvessel-independent innervation of the 8th nerve and inner ear specimens in patients with otoneurological diseases. Specifically fluorescent adrenergic axons were scantily seen among the myelinated nerve fibers in the 8th nerve and in the subepithelial regions of the end organs but not in the endolymphatic sac.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455219
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    The autoimmune submandibular sialoadenitis of the NZB/NZW hybrid mice (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 225 (1979), S. 57-65 
    Details
    ISSN: 1434-4726
    Keywords: NZB/NZW-Maus ; Ultrastruktur ; Submandibulare Speicheldrüse ; Lymphocyten ; Autoimmunes Leiden ; NZB/NZW mouse ; Ultrastructure ; Submandibular gland ; Lymphocytes ; Autoimmune disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An electron microscopic study of the submandibular salivary gland lesion occurring in the NZB/NZW F1 hybrid mice was performed, and the findings were discussed and correlated to the autoimmune salivary gland disease observed in patients with Sjögren's syndrome. Within the submandibular salivary gland of this mouse strain focal infiltrates of mononuclear inflammatory cells were observed. Lymphoid cells were observed inside the basal lamina of acini and ducts, leading to destruction of these glandular units. The typical duct cell proliferation found in the autoimmune sialoadenitis of Sjögren's syndrome with the formation of the typical epimyoepithelial islands was not found in the submandibular glands of NZB/NZW mice.
    Notes: Zusammenfassung Eine elektronenmikroskopische Untersuchung der bei den NZB/NZW F1 hybriden Mäusen vorkommenden Veränderungen in den submandibularen Speicheldrüsen wurde durchgeführt, und die Befunde wurden diskutiert und korreliert mit dem autoimmunen Speicheldrüsenleiden, das bei Patienten mit Sjögrens-Syndrom beobachtet wird. In der submandibularen Speicheldrüse dieses Mäusestammes wurden begrenzte Infiltrationen mononuklearer inflammatorischer Zellen beobachtet. Die mononuklearen Zellen wurden hauptsächlich als lymphoide Zellen identifiziert. Außerdem wurden innerhalb der Lamina basilaris von Drüsen und Drüsengängen lymphoide Zellen beobachtet, die zur Zerstörung dieser Drüseneinheiten führen. Darüber hinaus wurde der typische Zuwachs der Drüsengangszellen, der bei der autoimmunen Speicheldrüsenentzündung des Sjögrens-Syndroms vorkommt und die Form von typischen epimyoepithelialen Inseln annimmt, in den submandibularen Drüsen der NZB/NZW-Mäuse nicht vorgefunden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455876
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    Ultrastructure of telangiectatic osteosarcoma (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 197-207 
    Details
    ISSN: 1432-1335
    Keywords: Telangiectatic osteosarcoma ; Histogenesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent investigations have shown that telangiectatic osteosarcoma has a poorer prognosis than other osteosarcomas. To elucidate the histogenesis of TOS two cases were investigated on the electron microscopic level. The results show that besides anaplastic, osteoblast-like, and fibroblast-like tumor cells angiosarcomatous components can be observed in this malignant bone tumor, which are characterized by endothelial cells with pinocytotic vesicles, tight intercellular junctions, fine fibrils, and so-called Weibel-Palade bodies in their cytoplasm. From these results, it is concluded that telangiectatic osteosarcoma is derived from multipotent mesenchymal cells with potential differentiation into various directions, such as osteoblast-like cells, endothelial cells, and fibroblast-like cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401013
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  • 81
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    Ultrastructural morphology of three-dimensional colonies of cells derived from a hepatocellular carcinoma (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 225-232 
    Details
    ISSN: 1432-1335
    Keywords: Cultured tumour cells ; Ultrastructure ; 3-D Colonies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured hepatocellular carcinoma cells were studied during anchorage-independent growth in semi solid medium (Methocel). The regular occurrence of mitotic figures both at the surface and within the colonies precludes the possibility of such colonies being formed by re-aggregation. The estimated population doubling time in the three-dimensional (3-D) colonies is consistent with those two-dimensional of (2-D) colonies. Structures resembling bile canaliculi were observed between the closely opposed membranes from the well packed adjacent cells. Cell surface and ultrastructural features of the colonies and individual cells are presented and comparisons made with 2-D growth of normal and malignant liver cells in vitro. The formation of 3-D colonies may not only be an assay for transformed cells but also for predicting the type of tumors produced by re-innoculation of the in vitro transformed cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410643
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    Die altersabhängige wirkung polychlorierter biphenyle auf die rattenleber (1979)
    Springer
    International archives of occupational and environmental health 44 (1979), S. 25-43 
    Details
    ISSN: 1432-1246
    Keywords: Electron microscopy ; Morphometry ; Freeze etching ; Liver ; Aging ; Polychlorinated biphenyls ; Elektronenmikroskopie ; Morphometrie ; Gefrierätzung ; Leber ; Altern ; polychlorierte Biphenyle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Untersuchung wurden jungen und alten männlichen Wistarratten polychlorierte Biphenyle (PCB) i.p. appliziert. Die altersbedingten und die hepatotoxischen Veränderungen in der Leber wurden licht- und elektronenmikroskopisch erfaßt. Des weiteren wurden Membranveränderungen mit der Gefrierätzung nachgewiesen. Neben den altersbedingten Veränderungen im Vergleich der beiden Kontrollkollektive fällt vor allem die exzessive Proliferation des glatten endoplasmatischen Retikulums auf, welche nach PCB-Applikation in den Hepatocyten nachzuweisen ist. Bei den jungen Ratten betrug die Vermehrung der Oberflächen-dichte dieser Membranen im Vergleich zu den Kontrolltieren 803% (P〈0,001) und bei den alten Ratten 282% (P〈0,001). Bei alten anderen untersuchten Parametern wurden sowohl bei den jungen als auch bei den alten Ratten statistisch signifikante Verringerungen nach PCB-Gabe festgestellt.
    Notes: Summary Thin-section and freeze-fracture techniques have been employed to investigate the ultrastructure of PCB-intoxicated rat liver of different ages. Besides alterations in the supramolecular structure of the plasma membranes, excessive proliferation of smooth endoplasmic reticulum (SER) in the hepatocytes was observed. In young rats, the surface density increased by up to 803% (P〈0.001) and in old rats up to 282% (P〈0.001) compared with the control rats. All other investigated parameters decreased significantly after the application of PCB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381206
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    Electronic Resource
    Feinstrukturelle und mikroanalytische Untersuchungen an den Kristallen und Lithosomen des CiliatenEuplotes vannus (1979)
    Springer
    Protoplasma 99 (1979), S. 67-77 
    Details
    ISSN: 1615-6102
    Keywords: Ciliata ; Crystals ; Euplotes ; Lithosomes ; Microanalysis ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In the cytoplasm of the marine ciliateEuplotes vannus, there exist two conspicuous types of membrane bound inclusions: 1. irregularly shaped crystals which are highly anisotropic; 2. globular lithosomes characterized by concentrically arranged layers of deposits which exhibit only faint birefringence. Normally, both structures form distinct accumulations. Energy dispersive X-ray microanalysis of these accumulations reveals a high content of calcium and phosphorus, besides magnesium, sulphur and chlorine. Analysis of cell areas devoid of the inclusions show significantly lower calcium- and phosphorus-peaks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274070
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  • 84
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    Electronic Resource
    Studies on the biology of fish bone. III. Ultrastructure of osteogenesis and resorption in osteocytic (cellular) and anosteocytic (acellular) bones (1979)
    Springer
    Calcified tissue international 28 (1979), S. 43-56 
    Details
    ISSN: 1432-0827
    Keywords: Bone resorption ; Osteogenesis ; Fish bone ; Osteocytes ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The comparative ultrastructure of fish bone osteogenesis and resorption induced by scale removal was described in the osteocytic (cellular-boned)Carassius auratus and the anosteocytic (acellular-boned)Tilapia macrocephala. Osteocytes, present in osteocytic bone, were lacking in anosteocytic bone. In osteocytic bone the osteoblast secreted a collagenous preosseous matrix in which it became enmeshed and then was termed a preosteocyte. When the preosseous matrix mineralized, the preosteocyte was termed an osteocyte and was completely surrounded by bone. In anosteocytic bone the osteoblasts receded from the mineralizing front and never became trapped as osteocytes. During resorption, types A and B resorptive cells, present in both bone types, invaded the matrix and demineralized the osseous zone. These cells were characterized by large amounts of granular endoplasmic reticulum and intracellular inclusions containing crystal-like material. Although functionally similar to mammalian osteoclasts, these cells lacked a characteristic ruffled border and were not multinucleated. The osteocytes of cellular bone did not appear to be involved during demineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441217
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  • 85
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    Electronic Resource
    Ultrastructure of skeletal muscle after CO2-laser incision (1979)
    Springer
    Research in experimental medicine 176 (1979), S. 69-79 
    Details
    ISSN: 1433-8580
    Keywords: Skeletal muscle ; CO2-laser ; Surgery ; Ultrastructure ; Rat ; Skelettmuskelfaser ; CO2-Laser ; Chirurgie ; Ultrastruktur ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Zustand der dorsalen Haut und des darunterliegenden Muskelgewebes der Ratte wurde unmittelbar nach CO2-Laser-Schnitten mit Hilfe von licht- und elektronenmikroskopischen Methoden untersucht. In der subkutanen Skelettmuskelschicht konnte eine erhöhte Empfindlichkeit des Gewebes festgestellt werden, die in einer ausgeprägten Abfolge von Zellveränderungen ihren Ausdruck findet. Diese Schädigungen werden hauptsächlich den thermischen Effekten der Laserstrahlung zugeschrieben. Die Bedeutung dieser Untersuchungsergebnisse in Hinblick auf die Verwendung von Laser in der Chirurgie wird besprochen.
    Notes: Summary The immediate effect of CO2-laser incision to the dorsal skin and underlying muscular tissue of rats was studied by light and electron microscopical methods. In the subcutaneous layer of skeletal muscle cells an increased susceptibility was found, resulting in distinct zones of cellular changes which are attributed mainly to thermal effects of the laser beam. The importance of these findings for the surgical application of lasers is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852112
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  • 86
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    Electronic Resource
    Licht- und Elektronenmikroskopische Leberbefunde beim Cerebro-Hepato-Renalen Syndrom nach Zellweger (Peroxisomen-Defizienz) (1979)
    Springer
    Virchows Archiv 384 (1979), S. 269-284 
    Details
    ISSN: 1432-2307
    Keywords: Cerebro-hepato-renal syndrome ; Zellweger's syndrome ; Peroxisome deficiency ; Liver cirrhosis ; Liver biopsy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For histologic differential diagnosis of fibrotic and cirrhotic liver changes in early infancy Zellweger's cerebro-hepato-renal syndrome has to be considered. A case is reported where a female newborn failed to thrive and developed severe muscular hypotonia, defective intelligence, and seizures. At an age of 12 months an open biopsy was taken from the enlarged liver. Biochemical tests for disorders of carbohydrate metabolism were negative. The light microscopic examination showed severe fibrosis, lobular disarray, and single cell necroses. Neither siderin nor bile pigment could be detected. There were no changes of the small bile ducts and no signs of inflammation — the child died at 18 months. A postmortem needle biopsy of the liver showed the advanced stage of micronodular cirrhosis. The electron microscopic examination of the first biopsy revealed hypertrophy of smooth endoplasmic reticulum, probably induced by anticonvulsive drugs. The mitochondria showed an increase in the density of their matrix and in the number of sometimes tubular cristae. In accordance with reports in literature, no regular peroxisomes (microbodies) could be found in the hepatocytes. Only a very few profiles with an average diameter of 0.16 μm looked like rather small peroxisomes. The cytoplasmic volume fraction of those organelles, however, amounted to 3×10−5 which is only 1/500 of the normal value in human hepatocytes. Although the significance of the absence of peroxisomes is not yet definitively proved, the term ‘Peroxisome Deficiency’ is proposed as a name which probably is more closely related to the pathogenetic mechanism than the hitherto usual designation cerebro-hepato-renal syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428229
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  • 87
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    Electronic Resource
    Zur Pathogenese der calcifizierenden odontogenen Cyste (Gorlin-Cyste) (1979)
    Springer
    Virchows Archiv 384 (1979), S. 307-324 
    Details
    ISSN: 1432-2307
    Keywords: Calcifying odontogenic cyst ; Dysplastic dentin ; Hornified cells ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four new cases of calcifying odontogenic cyst (COC) were studied by light- and electronmicroscope. The ages of the patients were between 20 and 68 years. Three cysts were located in the maxilla, the other was in the mandible. The history of two patients was followed up for five and ten years respectively. The longer the history the bigger were the cysts. All cysts showed histologically identical alterations of the epithelium with 1) a pronounced cylindrical basal cell layer, 2) cells resembling stellate reticulum, and 3) ghost cells. So called dysplastic dentin was laid down in the connective tissue only in the two cases with a long history. Ultrastructurally the odontogenic epithelium of all cysts showed keratinization similar to the epidermis. Two types of keratinization are known to occur in the epidermis, soft keratinization with keratohyalin granules in ortho- and parakeratosis, and hard keratinization without keratohyalin granules in nails (horn). Both types of keratinization occur in odontogenic epithelium. The COC is an example of hard keratinization. Ghost cells form prekeratin which in turn becomes horn and is found in areas of confluent ghost cells and in the so called dysplastic dentin. We conclude that the alteration of odontogenic epithelium in COC and in special odontogenic tumors is a secondary phenomenon resembling ortho- and parakeratosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428232
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  • 88
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    Electronic Resource
    The trabecular meshwork of a non-glaucomatous eye with the exfoliation syndrome (1979)
    Springer
    Virchows Archiv 384 (1979), S. 347-355 
    Details
    ISSN: 1432-2307
    Keywords: Exfoliation syndrome ; Non-glaucomatous eye ; Trabecular meshwork ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The trabecular meshwork of a non-glaucomatous eye with the exfoliation syndrome was investigated. The exfoliation material was found mainly in massive deposits in the subendothelial region of the outer and inner wall of Schlemm's canal, in the cribriform area and the uveal meshwork. The other alterations of the trabeculum corneosclerale corresponded to the age of the patient. The concept that the accumulation of exfoliation material is an important pathogenetic factor in the development of glaucoma was not confirmed by this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428235
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  • 89
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    Electronic Resource
    Studies on the development of cell contacts and of the intercellular matrix during decidualization in the rat (1979)
    Springer
    Archives of gynecology and obstetrics 227 (1979), S. 103-117 
    Details
    ISSN: 1432-0711
    Keywords: Decidua ; Interzelluläre Verbindungen ; Gefrierätzen ; Elektronenmikroskopie ; Fibrinoid ; Decidua ; Intercellular junctions ; Freeze-fracturing ; Electron microscopy ; Fibrinoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cell contacts between developing decidual cells were examined in thin sections and in replicas of freeze-cleaved tissue of rat uterus. At the time of implantation only puncta adhaerentia were found between stromal cells. Gap junctions appeared 24 h after decidualization and thereafter increased in number and extent. Thus, there is little morphological evidence for a propagation of the initial stimulus for decidualization via gap junctions. An increase in amorphous, extracellular material is noted after decidualization with a concomitant decrease of collagen fibers. This amorphous material probably represents fibrinoid.
    Notes: Zusammenfassung Die Zellkontakte zwischen sich entwickelnden Deciduazellen wurden sowohl mit der Dünnschnittechnik als auch mit der Gefrierätzmethode im Rattenuterus untersucht. Zum Zeitpunkt der Implantation wurden nur Puncta adhaerentia zwischen Stromazellen gefunden. Nexus (gap junctions) erschienen 24 h nach Beginn der Decidualisierung und nahmen danach an Zahl und Größe zu. Diese morphologischen Befunde widersprechen der Ansicht, daß sich der initiale Reiz für die Decidualisierung der Stromazellen über Nexus ausbreitet. Nach der Decidualisierung wurde eine Zunahme von amorpher, extrazellulärer Substanz gleichzeitig mit einer Abnahme von Kollagenfasern gesehen. Diese amorphe Substanz stellt wahrscheinlich Fibrinoid dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02103284
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  • 90
    Electronic Resource
    Electronic Resource
    Orientation of apatite in single osteon samples as studied by pole figures (1979)
    Springer
    Calcified tissue international 29 (1979), S. 101-105 
    Details
    ISSN: 1432-0827
    Keywords: Osteon ; X-ray diffraction ; Pole figures ; Electron microscopy ; Calcification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The X-ray diffraction method based on pole figures has been applied to single osteon samples in order to obtain information about the texture of the inorganic bone fraction and the way it changes during calcification. The osteon samples were cylindrically shaped, with axes corresponding to those of the haversian canals. Selection was carried out according to the degree of calcification and the orientation of collagen bundles and inorganic particles. Osteons at both the initial and final stages of calcification were chosen. Arrangements of fiber bundles and inorganic particles in successive lamellae characteristic of three types of osteons were selected: longitudinal, alternate, and transversal. The results indicate that in all three types of osteons, the long axis of the sample is apparently the only direction of orientation because the transversally oriented crystallites give an isotropic diffuse scattering as would be expected if all the inorganic particles were irregularly oriented around the osteon axis. The number of longitudinally oriented crystallites increases progressively from transversally oriented osteons to alternately and longitudinally oriented ones. The crystallite orientation in an axial direction increases in fully calcified osteons. This last result is in agreement with the electron microscopic finding that the long needle-shaped crystallites covering much more than a major collagen period and measuring 40–45 Å in width increase in number as calcification proceeds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408064
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  • 91
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    Electronic Resource
    Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow (1979)
    Springer
    Annals of hematology 39 (1979), S. 177-190 
    Details
    ISSN: 1432-0584
    Keywords: Chronische myelo-monozytäre Leukämie ; Seeblaue Histiozyten ; Knochenmarksbiopsie ; Elektronenmikroskopie ; Chronic myelomonocytic leukemia ; Sea-blue histiocytes ; Bone marrow biopsy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Clinical data and light and electron microscopic findings are presented in a patient with chronic myelomonocytic leukemia of about 5 years' duration and no need for specific therapy. Cytogenetic studies failed to demonstrate a Philadelphia-chromosome. The leading clinical symptoms were anemia, moderate hepatomegaly, and leukocytosis with monocytes in the peripheral blood count. Light microscopy of bone marrow cores showed hypercellularity of neutrophil granulocytic and monocytic cell lines including some precursor forms. Electron microscopy confirmed the existence of a biphasic myelomonocytic cell proliferation with predominance of mature forms in both lineages; there were no gross cellular abnormalities and no “hiatus leukaemicus”. Conspicuous were cells of an undeterminated origin apparently neither belonging to the neutrophil granulocytic nor monocytic series and large histiocytic cells, possibly corresponding to the so-called sea-blue histiocytes of light microscopy. The high degree of maturation of both cell lines in the bone marrow is in accordance with the relatively benign and prolongated course of this rare type of leukemia.
    Notes: Zusammenfassung Von einem Patienten mit einer chronischen myelo-monozytären Leukämie von etwa 5 Jahren Dauer und ohne spezifische Therapie werden klinische sowie licht- und elektronenmikroskopische Befunde vorgestellt. Zytogenetische Untersuchungen ließen ein Philadelphia-Chromosom nicht erkennen. Die führenden Symptome waren eine geringe Anämie, eine mäßige Lebervergrößerung und Leukozytose mit Monozyten im peripheren Blutausstrich. Lichtmikroskopische Untersuchungen des Knochenmarkes zeigten eine Zellvermehrung der neutrophilen granulozytären und der monozytären Zellreihen einschließlich einiger Frühformen. Die Elektronenmikroskopie bestätigte das Vorhandensein einer biphasischen myelo-monozytären Zellproliferation mit Vorwiegen der reifen Formen in beiden Zellinien. Es bestanden keine bemerkenswerten zellulären Anomalien und kein „hiatus leucaemicus“. Auffallend waren Zellen unbestimmbarer Herkunft, die weder der neutrophilgranulozytären oder monozytären Reihe sicher zuzuordnen waren, und große histiozytäre Zellen, die wahrscheinlich den sogenannten „seeblauen Histiozyten“ der Lichtmikroskopie entsprechen. Der hohe Grad der Ausreifung in beiden Zellinien im Knochenmark steht in Übereinstimmung mit dem relativ gutartigen und langen Verlauf dieses seltenen Types einer Leukämie.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008447
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  • 92
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    Electronic Resource
    Light and electron microscopic findings in five cases of cryoglobulinemic glomerulonephritis (1979)
    Springer
    Virchows Archiv 384 (1979), S. 29-44 
    Details
    ISSN: 1432-2307
    Keywords: Glomerulonephritis ; Cryoglobulinemia ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal tissue from five patients with cryoglobulinemia was studied by light and electron microscopy and immunofluorescence. None of the histologic features observed at the light microscopic level seems to be specific for cryoglobulinemia. Electron microscopic investigations have shown very large electron dense deposits in almost every examined lobule in all cases. The deposits displayed two main patterns; a homogeneous texture in two cases and tubular or annular structures in three cases. The patients with typically structured deposits had IgG-IgM cryoglobulinemia (2 cases) or monoclonal IgM cryoglobulinemia (1 case). The presence of IgM in cryoglobulinemia may be the cause of the peculiar structure of the deposits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427149
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  • 93
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    Electronic Resource
    Adrenal adenomata causing primary aldosteronism (1979)
    Springer
    Virchows Archiv 384 (1979), S. 93-102 
    Details
    ISSN: 1432-2307
    Keywords: Primary aldosteronism ; Adrenal adenomata ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adenomata taken from 25 patients with primary aldosteronism were observed by electron microscopy. The cells in the adenoma had a well developed agranular endoplasmic reticulum but granular endoplasmic reticulum was not prominent. Most of the mitochondria resembled those in the cells of the zona glomerulosa, suggesting that the adenomata which caused primary aldosteronism are derived from this zone. Spironolactone bodies were found in the cells of the adenoma from a patient who received spironolactone. Their appearance was identical to that descrived in previous reports.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427154
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  • 94
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    Electronic Resource
    Rat liver alterations after chronic treatment with hexachlorobenzene (1979)
    Springer
    Virchows Archiv 382 (1979), S. 127-137 
    Details
    ISSN: 1432-2307
    Keywords: Hexachlorobenzene ; Liver ; Ultrastructure ; Porphyrins ; Smooth endoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Groups of female rats were treated orally with 0.5, 2.0, 8.0, and 32 mg/kg hexachlorobenzene twice a week for 203 days. The liver content of hexachlorobenzene was found to be dose-dependent. In the animals treated with the highest dose the concentration was 273 μg/g hexachlorobenzene. In the fresh and fixed hepatic tissue of the treated animals pink fluorescence was observed. Electron microscopy revealed a dose dependent enlargement of all hepatocytes due to proliferation of the SER in the centrolobular area or to increased glycogen deposits (β- or α-particles) and SER in the intermediary and periportal area. Numerous porphyrin deposits and siderosomes, intimate disorganisation and moderate dislocation of the RER and a moderate enlargement of bizarre-shaped mitochondria were recognized. The relationship between porphyrin crystals and mitochondria on the one hand and between SER and glycogen deposits on the other is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102869
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  • 95
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    Electronic Resource
    The fine structure of meningiomas: An attempted classification (1979)
    Springer
    Virchows Archiv 382 (1979), S. 201-216 
    Details
    ISSN: 1432-2307
    Keywords: Meningioma ; Ultrastructure ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined 23 meningiomas by electron microscopy. In each case it was possible to distinguish certain cells with epithelial features (desmosomes, microfilaments, interdigitating extensions) and others with fibroblastic features (collagen fibers). Others cells of transitional form were also seen. The proportion of these cellular types is variable, making it possible to classify meningiomas into seven types progressing gradually from a purely epithelial type to a purely fibroblastic one. We found no important ultrastructural abnormalities in the cells. These case reports confirm the uniqueness of meningiomas, which are composed of variously shaped cells but have their origin from a single cellular type. This has double potentiality for fibroblastic and epithelial differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102875
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  • 96
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    Electronic Resource
    Ultrastructural observations on axonal swelling in the human gracile nucleus (1979)
    Springer
    Virchows Archiv 382 (1979), S. 217-226 
    Details
    ISSN: 1432-2307
    Keywords: Axonal swelling ; Spheroid ; Dystrophic axon ; Ultrastructure ; Human gracile nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology of the spheroids in human gracile nuclei was studied by light and electron microscopy. Various spheroids encountered in the present study could be classified into three types based on the internal structure: The first one was chiefly composed of many irregular homogeneous dense bodies, multivesicular bodies and mitochondria. The dense bodies seemed to deposit multicentrically in an axon in the early stage of “balloon” formation and coalesce to form larger ones. The second was characterized by a marked accumulation of closely approximated mitochondria and dense concentric bodies. In the third the most characteristic findings were neurofibrillary accumulation and aggregations of dense bodies. These findings showed some divergence from those of dystrophic axons and the last two mimic those of degenerative or regenerative axons, which suggested that axonal swelling (including dystrophic axon) is not characteristic reaction of specific disease but rather nonspecific one to a variety of noxious stimuli. With light microscope, it was difficult to distinguish balloons with different structures since they were quite diverse and manifold in their shape, size, appearance and stainability. Intra-axonal corpora amylacea were seen in most cases and their incidence appeared to be nonspecific for any diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102876
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  • 97
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    Electronic Resource
    Malignant giant cell tumor of tendon sheath (1979)
    Springer
    Virchows Archiv 382 (1979), S. 237-243 
    Details
    ISSN: 1432-2307
    Keywords: Giant cell tumors of tendon sheath ; Soft tissue tumors ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A benign, but aggressive, giant cell tumor of tendon sheath developed over a period of 20 years into a metastasizing, histologically malignant giant cell tumor. Ultrastructure of the malignant tumor showed the same five cell types as described in giant cell tumors of tendon sheath. Even the same crystals were identified in the osteoblast-like and osteoclast-like cells. It therefore appears reasonable to assume that giant cell tumors of tendon sheath indeed are neoplasms with a malignant potential and not an inflammatory reaction of synovial cells as previously suggested. Both the benign and malignant tumors seem to be of mesenchymal derivation with partial osseous differentiation. No ultrastructural similarities with fibrous histiocytoma were apparent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01102878
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  • 98
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    Electronic Resource
    Emiocytotic granule release without intraluminal stimulus in human colonic endocrine cells of fetuses, children and adults (1979)
    Springer
    Virchows Archiv 382 (1979), S. 283-291 
    Details
    ISSN: 1432-2307
    Keywords: Emiocytosis ; Endocrine cells ; Human embryo, child and adult ; Large intestine ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In endocrine cells of the colon of adults, children and fetuses, exocytotic granule release without any specific stimulation is reported. Omega-invaginations are observed on both the lateral and basal surfaces of all types of colonic endocrine cells. Several explanations for the phenomenon are suggested: 1) emiocytosis is probably more frequent in the colon than in the proximal gut, this allows its observation without requiring an exogenous stimulus, 2) since most of the exocytotic figures are from anaesthetized subjects it is also assumed that contraction of the muscular layer induced by anaesthetics and the resulting increase in intraluminal pressure were the possible causes of granule release, 3) in non-anaesthetized subjects release may have taken place in response to a normal endogenous physiological stimulus, or to the dilation of colon during colonoscopy. Less likely is an effect associated with the preparation for colonoscopy. Certain figures on lateral surfaces between endocrine and adjacent cells i.e., bulges of parallel plasma membranes surrounding a secretory granule, were observed. Their significance is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430404
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  • 99
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    Electronic Resource
    Ultrastructural studies on the evolution of amyloidosis in the cyclic hematopoietic (CH) dog (1979)
    Springer
    Virchows Archiv 383 (1979), S. 167-179 
    Details
    ISSN: 1432-2307
    Keywords: Amyloidosis ; cyclic hematopoiesis ; Animal model ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopy studies were made on tissues of cyclic hematopoietic (CH) dogs of various ages presenting a high incidence of spontaneous amyloidosis. The distribution and morphologic characteristics of amyloidosis in this animal model closely correspond to the secondary and familial forms of the disease in humans. Plasma cells and, particularly, macrophages presented marked changes during the evolution of amyloid deposition. Residual bodies in the macrophages contained abundant cell debris, a result of both endocytic and autophagocytic activities. Intracellular amyloid fibrils were not observed by conventional electron microscopy. A few reticular cells contained intracytoplasmic fibrils which were morphologically different from amyloid. There was no correlation between the amount of intracellular fibrils and the size of the extracellular amyloid deposits. On the contrary, a temporal association between the magnitude of the amyloid deposits and cytoplasmic changes in the macrophages at sequential stages of the evolution of the disease was evident. It is suggested that the hematopoietic defect in the CH dog could play an important role in the production of amyloidosis, making this animal an excellent experimental model for studies of that disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200897
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  • 100
    Electronic Resource
    Electronic Resource
    Zur Ultrastrukturpathologie der vorbehandelten Basedow-Struma (1979)
    Springer
    Virchows Archiv 383 (1979), S. 181-193 
    Details
    ISSN: 1432-2307
    Keywords: Graves' disease ; Preoperative treatment ; Ultrastructure ; Antithyroid drug treatment ; Lithium ; Cellular involution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This electron microscopic study is based on 12 cases of toxic goiter treated preoperatively with iodide, thionamides and lithium. Essential features of Graves' disease include hypertrophy of the follicular epithelium, papillary follicular infoldings and frequently, lymphocytic infiltration and fibrosis. After preoperative therapy most thyroid glands show involutional changes of varying degree with reaccumulation of colloid and flattening of the follicular epithelium. In a small number of histologically examined cases (n=84) colloid goitre (13%) and nodular goitre (8%) were noted. Lymphocytic infiltration and interstitial fibrosis do not show any correlation with preoperative treatment. Ultrastructurally, different stages of cellular involution are seen. The hypertrophic follicular cell shows an increased cell surface with numerous long microvilli and some pseudopodia at the apical border and an occasionally thickened, basal lamina. The cytoplasm contains a well developed system of organelles which synthesizes (rough endoplasmic reticulum, Golgi apparatus, cytoplasmic vesicles) and degrades (colloid droplets, lysosomes) thyroglobulin. With increasing cellular atrophy we found cells to be reduced in size but to contain well developed thyroglobulin-synthesizing organelles. Finally, we observed completely atrophic flat cells with only a few organelles. There are at date no electron microscopic communications on lithiumpretreated thyroid glands. After lithium therapy characteristic changes are observed at the membranes of the cytocavitary system, which are often found to be thin and occasionally to be damaged. The rough endoplasmic reticulum is virtually deprived of ribosomes and the Golgi apparatus seems to be underdeveloped. The number of apical microvilli is reduced. The morphological findings following iodide-, thionamide- and lithium pretreatment in Graves' disease are discussed in light of recent biochemical results.
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    URL: http://dx.doi.org/10.1007/BF01200898
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