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  • 1970-1974  (404)
  • 1965-1969  (86)
  • 1890-1899
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  • Rat  (319)
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  • 1
    Electronic Resource
    Electronic Resource
    The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 197-217 
    Details
    ISSN: 1432-1912
    Keywords: Intestinal Absorption ; Acidic Drugs ; Benzoic Acid ; Salicylic Acid ; Solvent Drag ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Jejunal loops of anaesthetized rats were perfused with hypotonic, isotonic and hypertonic buffered solutions containing 14C-labelled benzoic acid and salicylic acid at pH 6.2 and 2.2. The blood flow of the loop was maintained at an intermediate rate (0.78–0.97 ml min−1 g−1). The water net flux was determined by polyethylene glycol as non-absorbable marker and amounted up to +31 or-27 μl min−1 g−1. 2. A positive water net flux (leaving the gut lumen) increased the appearance rate of benzoic acid and salicylic acid in the intestinal venous blood by maximally 47 and 41%, a negative water net flux (entering the gut lumen) diminished the appearance rate by 28 and 37%. 3. The experimental data were analysed by means of a kinetic model. The parameters of the model were the epithelial permeability kF D , the serosal permeability k S F S and the sieving coefficient Φ=1−σ. The epithelial permeability was 0.115 and 0.107 for benzoic acid and salicylic acid at pH 6.2 and increased to 0.163 and 0.185 ml min−1 g−1 at pH 2.2. The serosal permeability was assumed to be identical for neutral and acidic pH and amounted to 0.046 and 0.112 ml min−1 g−1 indicating that a certain proportion of the absorbed drugs was transferred to the serosal side. The sieving coefficient was 2.92 and 2.31 at neutral pH and 3.79 and 3.56 at acidic pH. 4. The main resistance to the absorption of the two drugs is the epithelial membrane, since the effective blood flow and the unstirred layer are not ratelimiting. The high sieving coefficient for the two drugs is interpreted as indicating an interaction of drug and water molecules inside the lipid part of the cell membrane (which contains at least 30% water). The electric potential across the gut wall may contribute to the size of the sieving coefficient, if the drug molecules permeate also in the ionized form. 5. Using acidic perfusion solutions the epithelial permeability and the sieving coefficient were increased by the factor 1.3–1.5. This increase can be explained sufficiently by a facilitated entrance of the unionized drug molecules into the epithelial membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503498
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  • 2
    Electronic Resource
    Electronic Resource
    Dekorporierung von Thallium durch rhyolithischen Bims bei der Ratte (1974)
    Springer
    Research in experimental medicine 162 (1974), S. 63-66 
    Details
    ISSN: 1433-8580
    Keywords: Rhyolithic pumice ; Ferrihexacyanoferrate (II) ; Thallium ; Rat ; Rhyolithischer Bims ; Ferrihexacyanoferrat (II) ; Thallium ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Orale Verabfolgung von rhyolithischem Bims bewirkt eine herabgesetzte Retention von Thallium in den Geweben. Die Wirksamkeit von Rhyolith zeigt eine ausgeprägte Dosisabhängigkeit, ist aber geringer als die von Ferrihexacyanoferrat (II).
    Notes: Summary Oral administration of rhyolith leads to a diminished retention of thallium by the tissues. The effectiveness of rhyolith markedly depends on its dosage, but is surpassed by that of ferrihexacyanoferrate (II).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851884
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Beeinflussung der renalen Exkretion von D-Penicillamin bei der Ratte (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 39-45 
    Details
    ISSN: 1433-8580
    Keywords: D-penicillamine ; Acetazolamide ; Renal excretion ; Rat ; D-Penicillamin ; Acetazolamid ; Renale Exkretion ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die renale Ausscheidung von D-Penicillamin läßt sich weder durch Probenecid noch durch N-Methylnicotinamid oder NH4Cl beeinflussen. Acetazolamid bewirkt eine erhöhte Retention von D-Penicillamin in Haut und Muskulatur und hemmt dessen renale Ausscheidung, hat jedoch keinen Effekt auf die Dekorporationswirksamkeit von D-Penicillamin bei60Co. Die möglichen Ursachen des Einflusses von Acetazolamid auf die Verteilung und Exkretion von D-Penicillamin werden diskutiert.
    Notes: Summary The renal excretion of D-penicillamine is not influenced by probenecid, N-methylnicotinamide, and NH4Cl. Acetazolamide brings about an increased retention of D-penicillamine in skin and muscles and lowers its urinary excretion, but does not exhibit any influence on the efficacy of D-penicillamine in removing internally deposited60Co. The possible causes for the action of acetazolamide on the distribution and excretion of D-penicillamine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851444
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental uremic syndrome in the rat (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 341-349 
    Details
    ISSN: 1433-8580
    Keywords: Experimental uremic syndrome ; Rat ; 5/6 reduction of renal parenchyma ; Serum- and urine analysis ; Secondary hyperparathyroidism ; Experimentelles urämisches Syndrom ; Ratte ; 5/6-Reduktion des Nierenparenchyms ; Serum- und Urinanalyse ; Sekundärer Hyperparathyreoidismus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch eine 5/6-Nierenparenchymreduktion wurde an Ratten ein chronisches, durch bilaterale Nephrektomie ein akutes urämisches Syndrom erzeugt. Beim chronischen urämischen Syndrom erwiesen sich in der Serumanalyse die Konzentrationen des Harnstoffstickstoffs und des Kreatinins als wesentlich erhöht. Darüber hinaus bestanden alle chemischen Zeichen eines sekundären Hyperparathyreoidismus. Die Tiere litten außerdem an einer schweren Poly-, Protein- und Albuminurie. Überraschenderweise war aber der Spiegel des totalen Serumproteins gegenüber den Kontrolltieren erhöht. Das experimentelle chronische urämische Syndrom stellt eine extreme Adaptation der regulatorischen Aktivität des Nierenrestparenchyms und des ganzen Organismus dar. Beim akuten, durch bilaterale Nephrektomie erzeugten urämischen Syndrom besteht dagegen ein schweres Versagen der Regulation des Wasser- und Elektrolytstoffwechsels, welches innert 50–60 Std zum Tode der Versuchstiere führt.
    Notes: Summary A chronic uremic syndrome was induced by 5/6 nephrectomy and an acute uremic syndrome by bilateral nephrectomy in rats. In the chronic uremic syndrome serum and urine analysis revealed a highly increased serum level of BUN and creatinine. Furthermore, all chemical signs typical of secondary hyperparathyroidism were present. The animals suffered from severe polyuria, protein- and albuminuria but, surprisingly, the total serum protein was increased. The experimental chronic uremic syndrome is, in essence, a syndrome of “extreme adaptation” of the regulatory activity of remnant renal parenchyma and of the whole body. In contrast, the acute uremic syndrome induced by bilateral nephrectomy is a severe disorder of water and electrolyte metabolism resulting in death of the experimental animals after 50–60 hrs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851521
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastruktur des proximalen Nierentubulus nach Behandlung mit einem Pentosanschwefelsäureester (1974)
    Springer
    Research in experimental medicine 164 (1974), S. 19-33 
    Details
    ISSN: 1433-8580
    Keywords: Kidney ; Rat ; Ultrastructure ; Proximal tubule degeneration ; Heparinoid ; Niere ; Ratte ; Ultrastruktur ; Proximale Tubulusdegeneration ; Heparinoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 24 Std nach i.v. Injektion von 100 mg/kg eines Pentosanschwefelsäureesters (SP 54) sind in der Nierenrinde von Ratten schwere degenerative Veränderungen der proximalen Tubuluszellen zu beobachten. Das Tubulusepithel ist flachkubisch umgewandelt, das Tubuluslumen ist angefüllt mit ausgestoßenen Mitochondrien und anderen Zelltrümmern. Am stärksten betroffen ist die Pars contorta des proximalen Tubulus. Weniger stark veränderte Tubuluszellen sind angefüllt mit Cytosomen, die eine spezifische Feinstruktur haben oder gehäuft gegenüber Kontrollen Cytoplasmaprotrusionen in das Tubuluslumen aufweisen. Die akute Tubulusdegeneration ist ein spezifischer Effekt von SP 54. Heparin bewirkt nur eine leichte Schwellung des Tubulusepithels, die häufiger auftritt als bei Kontrolltieren.
    Notes: Summary 24 hrs after the intravenous injection of 100 mg/kg of a Pentosansulfuricacidester (SP 54) severe degenerative alterations are observed in the proximal tubular cells in rat kidney cortex. The tubular epithelium has changed to a single layer of elongated cubic cells. The tubular lumen is filled with cellular debris and extruded mitochondria. The greatest change is seen in the pars contorta of the proximal tubule. Less degenerated tubular cells have a great number of cytosomes with a specific substructure or have cytoplasmatic protrusions into the tubular lumen. This acute tubular degeneration is a specific event after the administration of SP 54 and is not seen after an equimolar dosis of Heparin. Heparin induces only a slight swelling of the tubular epithelium, more frequent seen as in the control animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851961
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of coprophagy prevented by partial immobilization on calcium metabolism and bone morphology in the rat (1974)
    Springer
    Research in experimental medicine 162 (1974), S. 313-321 
    Details
    ISSN: 1433-8580
    Keywords: Coprophagy ; Rat ; Calcium metabolism ; Bone morphology ; Immobilization ; Koprophagie ; Ratte ; Calciumstoffwechsel ; Knochenmorphologie ; Immobilisierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir untersuchten den Einfluß der Koprophagie auf den Calciumstoffwechsel der Ratte. 20 Versuchstiere wurden durch Einschnüren in einen Lederpanzer an der Koprophagie gehindert und mit 21 Kontrolltieren gleicher Futteraufnahme verglichen. Die Kinetik des Calciumstoffwechsels wurde unter Verwendung von45Ca als Tracer analysiert. Die radiochemischen Resultate wurden mit den histologischen Beobachtungen an den Epi-Metaphysen der Kniegelenke verglichen. Bei den Versuchstieren mit verhinderter Koprophagie fanden wir: 1. ein hochsignifikant niedrigeres Körpergewicht; 2. eine hochsignifikante Verkleinerung folgender Parameter des Calciumstoffwechsels: Compartmentgröße und Austauschrate zwischen ihnen, Calciumausscheidungsraten, Knochenan- und -abbau; 3. eine Verschmälerung der Wachstumsfuge, verkürzte und verschmälerte primäre Knochenbälkchen, verminderte sekundäre metaphysäre Spongiosa. Bei 4 Versuchstieren, die in Lederpanzern gehalten, denen jedoch die Koprophagie ermöglicht war, wurden gleichartige histologische Veränderungen wie bei verhinderter Koprophagie festgestellt. Es wird gefolgert, daß die Verhinderung der Koprophagie keinen meßbaren Einfluß auf die Parameter des Calciumstoffwechsels hat.
    Notes: Summary We investigated the influence of coprophagy on the calcium metabolism of the rat. 20 experimental animals were prevented from coprophagy by wrapping them in leather harnesses and compared with 21 controls on the same food intake. Kinetics of calcium metabolism were analysed using45Ca as tracer. The radiochemical results were compared with the histological observations in the epi-metaphyses of the knee joints. In the experimental animals prevented from coprophagy we found: 1. a highly significant lower body weight; 2. a highly significant diminution of the following parameters of calcium metabolism: compartment sizes and exchange rate between them, calcium excretion rates, bone accretion and resorption; 3. a narrower epiphyseal growth cartilage, clearly shorter and narrower primary trabeculae, rarefied secondary metaphyseal trabeculae. Histological alterations identical to those observed with coprophagy prevented, were found in 4 animals kept in harnesses but with coprophagy allowed. It is concluded that prevention of coprophagy has no measurable influence on the parameters of calcium metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851702
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  • 7
    Electronic Resource
    Electronic Resource
    Wirkung steigender Pentagastrindosen auf die Säuresekretion des Rattenmagens nach Vagotomie im Perfusionsversuch (1974)
    Springer
    Research in experimental medicine 163 (1974), S. 289-298 
    Details
    ISSN: 1433-8580
    Keywords: Gastrinpentapeptide ; Vagotomy ; Acid secretion ; Perfusion test ; Rat ; Gastrinpentapeptid ; Vagotomie ; Säuresekretion ; Perfusionsversuch ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei männlichen Wistarratten wurde eine trunkuläre beiderseitige Vagotomie — ergänzt durch eine Pyloroplastik — angelegt. 4 Wochen später erfolgte in Urethannarkose eine Perfusion des Magens mit 0,9%iger NaCl-Lösung in Anlehnung an die Versuchsanordnung von Ghosh. Die Vollständigkeit der Vagotomie bestätigte ein Hypoglykämietest. Im Abstand von 150 min erhielten die Tiere — in 6 Gruppen zu je 10 Ratten — 2 × 50, 100, 150, 200, 250 oder 300 µg/kg KG Pentagastrin subcutan. Die statistisch ausgewerteten Ergebnisse lassen sich wie folgt zusammenfassen: 1. Die nach dem Abklingen der Wirkung der ersten Pentagastrininjektion wiederholte Pentagastringabe in derselben Dosis ergab bei allen Dosierungen eine höhere Säuresekretion als nach der ersten Injektion. 2. Ein Maximum der sezernierten Säuremenge wurde bei einer Dosis von 100 µg/kg KG erreicht. Bei höherer Dosierung des Pentagastrins nahm die Menge der sezernierten Säure signifikant ab.
    Notes: Summary Male Wistar rats were subjected to a complete bilateral vagotomy and a pyloroplasty. 4 weeks later followed in urethane anesthesia a continuous perfusion of the stomach with 0.9% saline according to the rat preparation of Ghosh. The completeness of the gastric vagotomy was confirmed by a postoperative insulin test. In an interval of 150 min the rats — in 6 groups of 10 rats each — were two times injected pentagastrin subcutaneously in dose rates of 50, 100, 150, 250 or 300 µg/kg body weight. The statistical confirmed results can be summarized as followed: 1. The second injection of pentagastrin — 150 min after the first — in the same dose produced a significantly higher gastric acid secretion in the rat all dose rates in comparison to the first injection. 2. The maximal gastric acid secretion was produced by a dose rate of 100 µg/kg body weight of pentagastrin. At higher dose rates of pentagastrin there was a significant reduction of gastric acid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851516
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  • 8
    Electronic Resource
    Electronic Resource
    On different patterns of dendritic bundling in the cerebral cortex of the cat (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 115-126 
    Details
    ISSN: 1432-0568
    Keywords: Cerebral cortex ; Apical dendrites ; Dendritic bundles ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In frontal, horizontal and sagittal paraffin sections through the cat's brain regional differences in the pattern of dendritic bundling have been investigated. It is shown that in the gyrus splenialis and suprasplenialis 2–5 apical dendrites of layer IV pyramids approach each other to form vertical bundles which run straight through layer IV. In the posterior sigmoid gyrus, on the other hand, most apical dendrites arising from the pyramidal cells bifurcate immediately above layer V and give rise to obliquely running branches which cross each other before turning upwards and joining other dendrites to take part in the formation of bundles. In this region the dendritic tree of the pyramidal cells seems to be characterized by an unexpectedly high degree of directional specialization.—In functional terms the findings can be summarized by stating that in the visual and sensorimotor regions of the cat's cerebral cortex basic differences exist in the relation between the apical dendrites of layer V pyramids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00525764
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  • 9
    Electronic Resource
    Electronic Resource
    Functional changes of the neuronal and glial elements at the surface of the external layer of the median eminence (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 255-262 
    Details
    ISSN: 1432-0568
    Keywords: Median eminence ; Neuro-vascular contacts ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The vascular surface of the external layer of the median eminence is composed of neuronal and glial processes. Neuro-vascular contacts are supposed to be necessary for the release of hypophysiotropic neurohormones. The present study confirms the hypothesis that the relative extent of neuro-vascular and glio-vascular contacts varies under different functional conditions of the tubero-hypophysial system. Morphometric analysis shows that in normal rats about 20% of the surface is lined by neuro-vascular contacts. After bilateral adrenalectomy the neuro-vascular contacts are enlarged to 40% whereas application of an extract of stalk-median eminence tissue is followed by a decrease of the neuro-vascular contacts to 15%. The implications of these results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519869
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  • 10
    Electronic Resource
    Electronic Resource
    Über die Entstehung der Basalmembranlabyrinthe (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 185-203 
    Details
    ISSN: 1432-0568
    Keywords: Basement membrane labyrinths ; Cerebral ventricles ; Development ; Rat ; Light and Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gehirne embryonaler und neugeborener Ratten wurden im Hinblick auf die frühe Entstehung der Basalmembranlabyrinthe licht- und elektronenmikroskopisch untersucht. 1. An den Hirngefäßen embryonaler Ratten der 2. und 3. Fetalwoche kommen zwar bereits Basalmembranen vor, sub- oder interependymale Basalmembranlabyrinthe fehlen aber noch. 2. Basalmembranlabyrinthe werden mit der Perjodsäure-Bisulfit-Aldehydthionin-Methode lichtmikroskopisch ab dem 20. Tag an umschriebenen Stellen des Ventrikelsystems gefunden; elektronenmikroskopisch treten die ersten Basalmembranlabyrinthe am 12. postnatalen Tag auf. 3. Die ersten interependymalen Labyrinthe erscheinen in Erweiterung der interependymalen Spalten in der Nähe von ausgedehnten Golgifeldern. Der Labyrinthinhalt besteht aus einer feinflockigen Substanz. Diese liegt wolkenartig angehäuft gegenüber bogenförmigen Ausbuchtungen lokal verbreiterter Zellmembranen. In Ausbildung begriffene Labyrinthe zeigen eine lamelläre Gliederung. 4. Ab dem 12. postnatalen Tag treten auch an den Basalmembranen der pericapillären Zellen, in denen lichtmikroskopisch Glykoproteide nachweisbar sind, zapfenartige Duplikaturen auf. Die Zapfen sind überwiegend ependymwärts gerichtet. Verbindungen zwischen den Basalmembranzapfen und den interependymalen Basalmembranlabyrinthen werden in den ersten 30 Lebenstagen nicht gefunden. 5. Sowohl an den die interependymalen Labyrinthe begrenzenden Plasmalemmata als auch am Plasmalemm der pericapillären Zellen fallen Stachelsaumbläschen auf, deren Membran in die Zellwand eingebaut wird. Ihr Inhalt scheint in die entstehenden Labyrinthe entleert zu werden. 6. Da sich an den tubulären Enden der Doppellamellen der Dictyosomen Strukturen befinden, die den Stachelsaumbläschen morphologisch gleichen, und da im Bereich des Golgifeldes und im Cytoplasma zwischen diesem und der Zellwand zahlreiche Stachelsaumbläschen liegen, wird angenommen, daß das Material der Basalmembranlabyrinthe dem Golgiapparat entstammt und vermittels der Stachelsaumbläschen zur Zellwand transportiert wird. Bogenförmige Ausbuchtungen lokal verbreiterter Zellmembranen im Bereich entstehender Labyrinthe werden als Reste von Stachelsaumbläschen aufgefaßt, deren Membran in die Zellwand eingebaut wurde. 7. Da die phylogenetische Zunahme des Hirnmantels mit einem Verlust der langen in das Gehirn reichenden basalen Ependymfortsätze an den größten Teilen der Ventrikelwand einhergeht und niedere Tiere noch nicht über Basalmenbranlabyrinthe verfügen, wird angenommen, daß diese die Transportfunktion für Stoffe aus dem Liquor übernommen haben, die vordem nach allgemeiner Auffassung über die langen Fortsätze in das Gehirn gelangten.
    Notes: Summary The brains of embryonic and new-born rats were investigated by means of light- and electron microscopy with regard to the early formation of basement membrane labyrinths. 1. Though basement membranes are already found around the brain capillaries of embryonic rats from the 2nd week of pregnancy, sub- and interependymal basement membrane labyrinths are still absent. 2. Basement membrane labyrinths, being demonstrable for light microscopy by a periodicacid-bisulfite-aldehydethionin-method, appear around the 20th day after birth at certain places of the ventricular system. By means of electron microscopy, basement membrane labyrinths have first been detected at the 12th postnatal day. 3. The earliest interependymal basement membrane labyrinths are found in enlargements of the interependymal spaces near a distended Golgi apparatus. The contents of the labyrinths, being composed of a loose flocculent material, are of a lamellar structure. In the intercellular space the material is situated opposite bow-shaped excavations of local broadenings of cell membranes. 4. From the 12th postnatal day, plug-like duplications of basement membranes occur at the ependymal side of the pericapillar cells, which contain glycoproteids. The plugs of basement membranes are directed towards the ependymal layer. No connections between the interependymal basement membrane labyrinths and the plugs of pericapillary basement membranes exist within the first 30 days of life. 5. At the plasmalemma of ependymal cells bordering the interependymal labyrinths, and at the cell membrane of pericapillary cells, coated vesicles are to be found, which are fused with the cell membrane. The contents of these vesicles seem to be released into the developing labyrinths. 6. At the tubular ends of dictyosomes, coated vesicle-like structures can be demonstrated. In the environment of the Golgi apparatus many coated vesicles are situated; they can even be found between the Golgi apparatus and the walls of labyrinthś. Therefore the coated vesicles are considered to be transport vesicles, transporting the material which is formed in the Golgi apparatus towards the cell membrane. 7. Since the phylogenetic increase of the brain mantle is accompanied by loss of the long processes of ependymal cells that reach far into the brain, and since lower animals have no basement membrane labyrinths, it is suggested that the basement membrane labyrinths have a transport functions for material from the cerebrospinal fluid which in lower animals is assumed to be transported by the long processes of ependymal cells.
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    URL: http://dx.doi.org/10.1007/BF00525769
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  • 11
    Electronic Resource
    Electronic Resource
    Feinbau und Passageverhalten der Capillaren im Subcommissuralorgan der Ratte (1974)
    Springer
    Anatomy and embryology 144 (1974), S. 101-122 
    Details
    ISSN: 1432-0568
    Keywords: Subcommissural organ ; Periodically structured bodies ; Vascular permeability ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Capillaren des Subcommissuralorgans (SCO) und deren Umgebung wurden an 38 adulten Sprague-Dawley- und an 6 adulten Wistar-Ratten nach Perfusionsfixierung im Elektronenmikroskop untersucht. Saure Mucopolysaccharide wurden mit Alcianblau und Rutheniumrot, Glykoproteide mittels der Perjodsäure-Silbermethenamin-Reaktion nachgewiesen. Der Stofftransport in den Capillaren wurde mit Meerrettichperoxidase (MRP) als Tracer untersucht. Die subcommissuralen Capillaren besitzen ein ungefenstertes, vesikelarmes Endothel, das einer einfachen, durchgehenden Basallamina aufsitzt. In der Umgebung der Capillaren finden sich neben periodisch strukturierten Körpern (PSK) vereinzelt Basallamina-Labyrinthe und regellos angeordnete kollagene Mikrofibrillen. Mit der Perjodsäure-Silbermethenamin-Reaktion lassen sich Glykoproteide im Bereich der Basallamina und der nach außen anschließenden Intercellularspalten darstellen, vereinzelt auch — teils im Bereich der Basallamina, teils ihr eng angeschlossen — Gruppen parallel angeordneter, linearer Strukturen mit einem periodischen Streifenmuster. Saure Mucopolysaccharide sind nur in der lumenseitigen Glykokalyx des Capillarendothels nachweisbar. Der Aufbau der PSK aus Kollagenfilamenten erscheint sehr wahrscheinlich. Vermutungen zur Entstehung dieser hochgeordneten Strukturen werden vorgebracht. Die Traceruntersuchungen ergeben, daß unter normalen Bedingungen in den subcommissuralen Capillaren eine Blut-Hirn-Schranke (BHS) für MRP besteht, die im Endothel lokalisiert ist. Bei einem Teil der Sprague-Dawley-Ratten ist die Barriere geschädigt und der Tracer gelangt über cytopemptische Vesikel in Basallamina und Gefäßumgebung. Der Basallamina und den PSK kommt in solchen Fällen keine besondere Schranken- oder Verteilerfunktion zu. Offenbar bewirkt bei manchen Sprague-Dawley-Ratten die MRP-Injektion über die Freisetzung von endogenen biogenen Aminen aus Mastzellen eine Schädigung der BHS, was bei Wistar-Ratten nicht eintritt.
    Notes: Summary The capillaries of the subcommissural organ (SCO) and their adjacent structures of 38 adult Sprague-Dawley rats and 6 adult Wistar rats were examined in the electron microscope after perfusion fixation. Acid mucopolysaccharides were shown by Alcian Blue and Ruthenium Red, glycoproteins were identified by the periodic acid-silver methenamine technique. Horseradish peroxidase (MRP) was used as a tracer for vascular permeability. The subcommissural organ's capillaries are characterized by an unfenestrated, continuous endothelium, showing only few vesicles; the endothelium is surrounded by a single, continuous basal lamina. Adjacent to the capillaries wall there are “periodically structured bodies” (PSK), labyrinths of the basal lamina and irregularly arranged collagen fibrils. Glycoproteins are found in the basal lamina and within the intercellular clefts; in a few cases groups of parallel arranged, periodically banded linear structures are seen within or adjacent to the basal lamina. Acid mucopolysaccharides are found within the endocapillary layer of capillaries. It seems very likely that PSK represent an atypical arrangement of collagen fibrils. The formation of these structures is discussed. Under normal conditions, MRP, after intravenous injection, does not enter the perivascular space surrounding the capillaries of the SCO. A blood-brain barrier exists at the level of the capillary endothelium. In a few Sprague-Dawley rats MRP seems to alter the permeability of the capillaries. Reaction product of MRP is found within endothelial vesicles and the adjacent structures. It appears that the basal lamina and the PSK are not involved in the barrier mechanism or regulation of transport. In Sprague-Dawley rats intravenous injection of MRP seems to alter the blood-brain barrier by release of endogenous biogenic amines associated with mast cell degranulation. This effect is not observed in Wistar rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00518636
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  • 12
    Electronic Resource
    Electronic Resource
    Changes of extent of Neuro-vascular contacts and number of neuro-glial synaptoid contacts in the pituitary posterior lobe of dehydrated rats (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 157-165 
    Details
    ISSN: 1432-0568
    Keywords: Neurohypophysis ; Neuro-vascular contacts ; Neuro-glial synaptoid contacts ; Dehydration ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The posterior lobe of the hypophysis consists of neurosecretory nerve fibres and glial cells, both abutting on the perivascular space of sinusoidal capillaries. Nerve fiberes and glial cells are connected with each other by a high number of synaptoid contacts. Several ultrastructural changes following dehydration have been described by other authors. This study presents the data of some morphometric investigations on normal and dehydrated rats. The relative extent of neuro-vascular contacts is not contstant; it increases significantly from 52 (±2.8)% in normal rats to 67(±1.2)% in rats with a dehydration time of 3 days. Correspondingly the extent of glio-vascular contacts is diminished. In addition, water-deprived animals show a clear increase in the number of neuro-glial synaptoid contacts with 3.1 (±0.4) per square unit nervous tissue compared to 2.1 (±0.3) per Square unit in untreated controls. These results indicate a dynamic motility of neuronal and glial elements depending on functional conditions, as was found for the external layer of the median eminence. Furthermore there seems to be a relationship between secretory activity and the number of neuroglial synaptoid contacts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315592
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  • 13
    Electronic Resource
    Electronic Resource
    Electron microscopic studies of the innervation of the rat kidney (1974)
    Springer
    Anatomy and embryology 145 (1974), S. 169-186 
    Details
    ISSN: 1432-0568
    Keywords: Renal innervation ; Rat ; Peripheral nerves ; Neuroeffector zones ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Rattenniere werden die muskelzellhaltigen arteriellen Gefäße und der juxtaglomeruläre Apparat innerviert. Blutgefäße mit Pericyten, porenhaltige Capillaren sowie die Tubuli der Rinde und des Markes werden nicht von Nervenfasern begleitet. Ganglienzellen wurden in der Rattenniere nicht beobachtet. Periphere Nerven mit einem ein-bis zweischichtigen Perineurium kommen im paravasalen Gewebe der Interlobar- und Arcuata-Arterien vor; sie enthalten neben zahlreichen marklosen Nervenfasern gewöhnlich auch 2–4 markhaltige. Nervenfaser-Bündel ohne perineurale Scheide finden sich im paravasalen Gewebe der Arcuata- und Interlobular-Arterien. Darüber hinaus sind in unmittelbarer Nachbarschaft der großen Arterien (Interlobar-, Arcuata- und Inter-lobular-arterien) und der Vasa afferentia marklose Nervenfasern und freie Axone vorhanden, die auch die proximalen Abschnitte der Vasa efferentia der subcapsulären und intermediären Rindenschicht begleiten. Im Nierenmark werden die juxtamedullären Vasa efferentia und die Arteriolae rectae innerviert; marklose Nervenfasern und freie Axone sind nur bis zur Außen-Innenstreifen-Grenze nachweisbar. Die Innervation der muskelzellhaltigen arteriellen Gefäße erfolgt durch aufgetriebene Axonabschnitte (Neuroeffektor-Zonen), die vorwiegend agranuläre Vesikel enthalten. Diese Strukturen liegen stets an der Grenze von Adventitia und Media bzw. Elastica externa; zwischen den glatten Muskelzellender Media wurden keine vesikelhaltigen Axonabschnitte gefunden. Als minimaler Abstand zwischen den vesikelhaltigen Axonabschnitten und den von einer Basalmembran umschlossenen glatten Muskelzellen (neuromuskuläre Distanz) wurden 600 Å gemessen. Die vorliegenden Ergebnisse werden mit den fluoreszenzmikroskopischen und histochemischen Untersuchungen über die adrenerge und cholinerge Innervation der Niere verglichen. Die sich aus diesem Vergleich ergebenden Probleme und funktionellen Konsequenzen für die Innervation der Niere sowie die Natur der cholinergen Fasern (afferente oder postganglionäre parasympathische Fasern) werden diskutiert.
    Notes: Summary The innervation of the rat kidney is defined by a system which supplies those arterial blood vessels whose walls contain smooth muscle cells and the juxtaglomerular apparatus. Vessels containing pericytes, or those vessels composed of an endothelium only, as well as the tubules of both the cortex and medulla, are not innervated. Furthermore, ganglion cells do not occur in the rat kidney. The nervous apparatus of the rat kidney consists of peripheral vegetative nerves, ensheathed by a perineurium, with 2–4 myelinated fibers running in the paravasal tissue of the interlobar and arcuate arteries, and of nerve bundles without a perineurial sheath in the paravasal tissue of the arcuate and interlobular arteries. Non-myelinated fibers and free axons occur in the immediate vicinity of the great arteries (interlobar, arcuate, and interlobular) and the vasa afferentia. Nerve fibers and free axons are also seen in the vicinity of only the proximal parts of those vasa efferentia which supply the cortical capillary plexus. The arteriolae rectae of the medulla, and their vasa efferentia, from which they arise, are innervated by non-myelinated fibers and free axons which accompany these arterial vessels only to the boundary of the outer and inner stripe of the outer zone of the medulla. The functional innervation of those vessels with smooth muscle cells results from neuro-effector zones which predominantly show agranular vesicles. These structures were never seen between the smooth muscle cells within the media; the minimum neuromuscular distance was 600 Å. The present findings are correlated with the lightmicroscopically demonstrated adrenergic and cholinergic innervation. The resultant problems and functional consequences of the innervation of the kidney, especially the nature of the cholinergic fibers (afferent or post-ganglionic parasympathetic fibers) are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519727
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  • 14
    Electronic Resource
    Electronic Resource
    Crossed reticulo-reticular projections in the medulla, pons and mesencephalon (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 127-134 
    Details
    ISSN: 1432-0568
    Keywords: Reticular formation ; Crossed connections ; Autoradiography ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Injection of radioactive leucine in various regions of the brain stem reticular formation has revealed the presence of ample crossed reticulo-reticular connections in the cat. The terminal area for the crossed fibers are almost mirror images of the injected sites. The findings made is another example that hitherto unknown fiber connections can be demonstrated by axoplasmic protein tracing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00525765
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  • 15
    Electronic Resource
    Electronic Resource
    Neuroembryogenesis in the hippocampal formation of the rat (1974)
    Springer
    Anatomy and embryology 144 (1974), S. 173-186 
    Details
    ISSN: 1432-0568
    Keywords: Hippocampus ; Neurogenesis ; Autoradiography ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summay The prenatal ontogeny of the hippocampus, including the anterior continuation and induseum griseum, was examined in the rat by means of tritiated thymidine autoradiography. The neurons of the anterior continuation formed between the 16th and 18th days of embryonic development. The neurons of the induseum griseum were formed on the 16th and 17th days of gestation. The pyramidal cells of ammon's horn were formed during the 16th, 17th, 18th, and 19th days of embryogenesis but were preceded by the large interneurons of the stratum lacunosum-moleculare which formed on days 15 and 16 of embryonic life. The granule cells of the superficial layers of the stratum granulosum formed during the 20th, 21st, and 22nd days of gestation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519773
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  • 16
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    Electronic Resource
    Morphological types of motor nerve terminals in rat hindlimb muscles, possibly innervating different muscle fiber types (1974)
    Springer
    Anatomy and embryology 144 (1974), S. 237-247 
    Details
    ISSN: 1432-0568
    Keywords: Motor nerve terminals ; Methylene blue stain ; Hindlimb muscles ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With methylene blue stain, three morphological types of motor nerve terminals were distinguished in hindlimb muscles (extensor digitorum longus, semitendinosus, soleus, and tibialis anterior muscles) of rat. Type A terminals possess many long thin branches with numerous minute swellings, type C ones possess few and thick terminal branches with few large swellings, and type B ones possess intermediate characteristics. The frequencies of occurrence of these types are characteristic for each muscle and differ between different hindlimb muscles. Specifically, soleus muscle contains a much higher proportion of type B terminals than other hindlimb muscles, and the superficial part of tibialis anterior muscle contains a higher proportion of type A terminals and a lower proportion of type C ones than the deep part. The frequencies of occurrence of types A, B, and C terminals closely parallel the frequencies of “white”, “intermediate”, and “red” muscle fibers (as determined by a fat stain), respectively, in the different muscles. As also suggested previously for the diaphragm, it is concluded that three morphological types of motor nerve terminals each may innervate one of three types of muscle fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00522809
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  • 17
    Electronic Resource
    Electronic Resource
    Evolution ultrastructurale du labyrinthe de placenta de chatte (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 1-20 
    Details
    ISSN: 1432-0568
    Keywords: Placenta ; Cat ; Differentiation ; Function ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'ultrastructure du labyrinthe de placenta de chatte a été étudiée du 45e au 63e jour de gestation. Cette formation endothéliochoriale est composée: d'un endothélium maternel hypertrophié et de cellules géantes déciduales; d'une couche de «substance inerte interstitielle»; du trophoblaste constitué d'une assise syncytiale continue (syncytiotrophoblaste) et d'une assise cellulaire discontinue (cytotrophoblaste); d'un endothélium foetal accompagné de son environnement mésenchymateux. Les capillaires foetaux envahissent progressivement le syncytiotrophoblaste. L'hypertrophie de l'endothélium maternel diminue en fin de gestation; de ce fait la distance, séparant le sang maternel du sang foetal, peut atteindre en certains points 2 μ. L'endothélium maternel, le syncytiotrophoblaste et l'endothélium foetal présentent des signes ultrastructuraux d'un rôle de transfert. La «substance inerte inerte interstitielle», qui sépare les tissus d'origine maternelle des tissus d'origine foetale, est constante mais d'épaisseur variable; elle est spécifique des structures endothéliochoriales. Les cellules géantes déciduales, dont le nombre diminue en fin de gestation comportent parfois un ou plusieurs «corps glycogéniques». Le syncytiotrophoblaste, siége d'activité de biosynthése de stéroïdes, est riche en ergastoplasme, ce qui autorise à postuler la synthése d'hormones protéiques.
    Notes: Summary The ultrastructure of feline placental labyrinth has been studied from the 45th to the 63rd day of gestation. The endotheliochorial structure is composed of: a thick hypertrophied maternal endothelium with giant decidual cells; an “interstitial inert substance”; a continuous syncytial layer (syncytiotrophoblast) and a discontinuous cellular layer (cytotrophoblast) of trophoblast; and a thin foetal endothelium with its surrounding mesenchyme. Foetal capillaries increasingly invade the syncytiotrophoblast. Maternal endothelial hypertrophy is reduced in the last days of gestation. Thus the interval between maternal and foetal bloods may in some areas become 2 μ, in late pregnancy. Foetal endothelium, syncytiotrophoblast, and maternal endothelium demonstrate ultrastructural features of transfer function. The “interstitial inert substance”, which separates maternal from foetal tissue was always evident though with variable thickness. The giant decidual cells which are reduced in late pregnancy, show one or several “glycogen bodies”. The syncytiotrophoblast, where some steroïd biosynthesis has been demonstrated, has an extensive rough endoplasmic reticulum suggestive of protein hormone synthesis activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341379
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  • 18
    Electronic Resource
    Electronic Resource
    Influence of pantothenic acid deficiency on the amount of CRF-granules in the rat median eminence (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 43-55 
    Details
    ISSN: 1432-0568
    Keywords: Pantothenic acid deficiency ; Corticotropin-releasing factor ; Corticoids ; Histologie ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the outer layer of the rat median eminence “Gomori-positive” granules occur which are assumed to be the morphological correlate of the corticotropin-releasing factor (CRF). The present study was carried out in order to establish whether the amount of these CRF-granules is influenced by a pantothenic acid (PA)-deficiency, which is known to result in an inhibition of corticosteroid production. Female SPF Wistar rats were used. PA-deficiency was induced by PA-free nutrition and/or administration of the PA-antagonist Ω-methyl-PA. Corresponding experimental groups were given either tap water or a solution of 1% NaCl and 5% glucose in tap water to drink. In rats fed with a diet free of PA and in addition treated with Ω-methyl-PA a severe disturbance of the corticoid balance developed within 6 weeks. The corticosterone production was depressed to about 11–16% of the control values. The adrenal cortex showed necrotic changes which either involved the whole parenchyma or were confined to the inner zones. In those animals in which a subcapsular region, in its extent corresponding to the zona glomerulosa, remained intact, an augmentation of the CRF-granules was observed. In those animals, however, in which the whole adrenal cortex was damaged, the amount of CRF-granules did not increase. Administration of the 1% NaCl containing drinking fluid did not influence the augmentation of the CRF granules, but had a protective effect on the development of necrotic changes in the zona glomerulosa of the adrenal cortex. The findings show that a functional relationship exists between the inner zones of the adrenal cortex and the CRF-granules in the median eminence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341382
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  • 19
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy demonstration of cilia in rat intrahepatic bile ducts (1974)
    Springer
    Anatomy and embryology 145 (1974), S. 223-226 
    Details
    ISSN: 1432-0568
    Keywords: Rat ; Liver ; Bile ducts ; Cilia ; Scanning Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Numerous cilia have been demonstrated by SEM in cells of rat perilobular and portal bile ducts and ductules. Generally these cilia appear as long, cylindrical evaginations of the plasma membrane. Some of them are so long that, curving and twisting at many points, they cross the ductal lumen. It has been suggested that they may be related to a continual mixing up and propulsion of the bile product down the biliary tree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519634
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  • 20
    Electronic Resource
    Electronic Resource
    The fine structure of the pulmonary stretch receptor in the rat (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 215-222 
    Details
    ISSN: 1432-0568
    Keywords: Lung ; Stretch receptors ; Light microscopy ; Electron microscopy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Lappenbronchien (3./6.) (Durchmesser bei mittlerer Inspirationslage 500–700 μ) von männlichen und weiblichen Wistarratten wurden licht- und elektronenmikroskopisch untersucht. Diese Bronchien entsprechen im Wandbau den mittleren Bronchioli größerer Säugetiere. Freie, verzweigte lanzettförmige Terminalfasern werden im Bindegewebe der lamina propria beschrieben. Sie sind in das elastisch muskuläre System der Bronchuswand eingebaut. Die zugehörige markhaltige afferente Nervenfaser ist verzweigt und hat einen Durchmesser von 4–6 μ. Außerdem werden efferente motorische Endigungen an der glatten Bronchialmuskulatur beschrieben. Die freien lanzettförmigen und verzweigten Terminalfasern sind möglicherweise Dehnungsrezeptoren für den Hering Breuer Reflex.
    Notes: Summary In rats the 3rd to 6th bronchi, measuring 500–700 μ in diameter during inspiration, were investigated by light and electron microscopy. The histological appearance of these bronchi is comparable to that of medium sized bronchioles of larger animals. The branched and lanceolate terminals are associated with the connective tissue of the lamina propria and the smooth muscle cell layer. In this way the terminals are bound to the myoelastic system of the bronchial wall. The myelinated afferent fiber is branched and the diameter measures about 4–6 microns. Besides afferent nerve terminals these are numerous efferent endings on the smooth muscle basement laminae. It is supposed that the described receptor represents the pulmonary stretch receptor of the Hering Breuer reflex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00525771
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  • 21
    Electronic Resource
    Electronic Resource
    Ganglienzellen und paraganglionäre Zellen des Ganglion cervicale superius der Ratte nach Parachlorophenylalanin (pCPA) (1974)
    Springer
    Anatomy and embryology 143 (1974), S. 223-237 
    Details
    ISSN: 1432-0568
    Keywords: Superior cervical ganglion ; Rat ; p-Chlorophenylalanine ; 5-Hydroxytryptamine ; Catecholamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung von Parachlorophenylalanin (pCPA) auf die paraganglionären Zellen und sympathischen Ganglienzellen des Ganglion cervicale superius der Ratte wurde untersucht. pCPA beeinflußt die sympathischen Nervenzellen im Ganglion cervicale superius geringgradig. Es finden sich unspezifische Veränderungen des Golgi-Apparates und der Nissl-Schollen sowie eine Zunahme von Lysosomen. Bei langdauernder Behandlung degenerieren einzelne Ganglienzellen und Nervenfasern. Die paraganglionären Zellen sind bei Kontrolltieren durch “dense core vesicles” eines einheitlichen Typs charakterisiert. Im Laufe der pCPA-Behandlung finden sich degranulierte paraganglionäre Zellen. Die Degranulation der einzelnen Zellelemente ist jedoch variabel. Bei fluorescenzmikroskopischer Untersuchung zeigt sich nach pCPA-Applikation eine Verschiebung des Fluorescenzspektrums zum grünen Bereich hin. Die bei Kontrollen deutliche Gelbkomponente nimmt nach 6–12 Tagen ab und verschwindet schließlich nach 18–20 Tagen. Es wird diskutiert, ob die fluorescenzmikroskopischen Veränderungen aufgrund einer Hemmung der Serotoninsynthese oder aufgrund einer abgeschwächten Katecholaminsynthese entstehen.
    Notes: Summary The effect of parachlorophenylalanine (pCPA) on the paraganglionic and sympathetic nerve cells of the rat superior cervical ganglion was studied. pCPA influences the sympathetic nerve cells of the cervical ganglion to minimal extent. Unspecific changes of the Golgi apparatus and of the Nissl bodies as well as an increase in the number of lysosomes occur. An extended period of treatment causes degeneration of individual ganglionic cells and nerve fibers. The paraganglionic cells in control animals are characterized by dense core vesicles of an unitary type. During pCPA treatment degranulated paraganglionic cells are to be found. The degranulation of the individual cell elements varies. Fluorescence microscopic study after pCPA application shows a shift of the fluorescence spectrum toward green. The yellow component of the control group decreases after 6 to 12 days and disappears after 18 or 20 days. It is discussed whether the fluorescence microscopic changes are due to the inhibition of serotonine synthesis or to a decrease of the catecholamine synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00519867
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  • 22
    Electronic Resource
    Electronic Resource
    Zur histogenese und cytogenese des tapetum lucidum cellulosum der katze (1974)
    Springer
    Anatomy and embryology 146 (1974), S. 141-156 
    Details
    ISSN: 1432-0568
    Keywords: Tapetum lucidum cellulosum ; Cat ; Development ; Light and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die postnatale Entwicklung des Tapetum lucidum cellulosum der Katze wird mit licht- und elektronenmikroskopischen Methoden untersucht. Bereits am ersten postnatalen Tag sind im Bereich des prospektiven Tapetum zwei Zellarten voneinander zu unterscheiden: 1. mesenchymale Bindegewebszellen und 2. prospektive Tapetumzellen, die durch elektronendichte Tapetumstäbchen gekennzeichnet sind. Die Mesenchymzellen unterteilen als parallel zur Retinaoberfläche ausgebreitete Zellplatten in der Choriodea am hinteren Augenpol den weiten extracellulären Raum in 20–25 etwa 5 μm hohe Schichten. Die Tapetumzellen liegen zwischen den Mesenchymzellplatten und wachsen im Verlaufe der ersten vier postnatalen Wochen innerhalb der Schichten in die Breite, bis sie den extracellulären Raum vollständig ausfüllen und als polygonale Zellen direkt aneinander grenzen. Im weiteren Verlauf der Entwicklung werden die Mesenchymzellplatten rückgebildet, so daß bei der adulten Katze die Tapetumzellschichten direkt übereinander liegen und nur von Netzen elastischer und kollagener Fasern getrennt sind. Die von einer Elementarmembran umgebenen Tapetumstäbchen enthalten einen elektronendichten, in den ersten postnatalen Wochen mit einer Periode von 100 Å quergestreiften Kern. Zunächst nehmen sie an Zahl und Länge zu und füllen am Ende der vierten postnatalen Woche, zu Bündeln von parallel verlaufenden Stäbchen geordnet, das Cytoplasma der Tapetumzellen. Dann nehmen die Tapetumstäbchen an Dicke zu, und ihre Querstreifung wird von einem elektronendichten Material überlagert. Die Entwicklung der Tapetumstäbchen hat eine starke Ähnlichkeit mit der in der Literatur beschriebenen Entwicklung von Melanosomen in Melanocyten. Das Tapetum lucidum cellulosum wird als ein dichter Verband hochdifferenzierter extrakutaner Melanocyten angesehen.
    Notes: Summary The postnatal development of the tapetum lucidum cellulosum of the cat was studied by light and electron microscopy. Already by the first postnatal day two cell types can be distinguished in the prospective tapeta area: 1. mesenchymal cells and 2. prospective tapetal cells, characterized by electron dense, membrane bound, rod-like inclusions. The flattened mesenchymal elements form 20–25 separate layers of cells, which are arranged parallel to the surface of the retina, subdividing the extracellular space of the chorioidea at the posterior pole of the eye into 5 μm high compartments. These compartments contain the tapetal cells which enlarge (in their longitudinal axis) during the first four weeks post partum until they occupy the extracellular space almost completely. At this stage, the tapetal cells are polygonal in shape and closely attached to each other. During the subsequent period of development there is a gradual involution of the mesenchymal cell plates. Thus, in adult cats the individual layers of tapetal cells are only separated from each other by networks of collagen and elastic fibers. The tapetal rods are bound by unit membranes and contain an electron dense core which, during the early postnatal weeks, exhibits a periodic cross-striation (100 Å). The tapetal rods increase in number and length during the first four weeks post partum; by the end of the fourth week, they occupy the whole cytoplasm of the tapetal cells. Parallelly arranged rods are grouped into individual bundles coursing inside the cytoplasm in different directions. Thereafter, the tapetal rods increase in thickness and their cross-striation becomes obscured by an electron dense material. This development of the tapetal rods closely resembles that of melanosomes. Thus the tapetum lucidum cellulosum can be regarded as a compact tissue made up of modified extracutaneous melanocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315591
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    Electronic Resource
    Effects of triparanol and 20,25-diazacholesterol in CNS of rat: Morphological and biochemical studies (1974)
    Springer
    Acta neuropathologica 29 (1974), S. 141-156 
    Details
    ISSN: 1432-0533
    Keywords: Cholesterol Inhibitors ; Cerebrum ; Neuronal Inclusions ; Oligodendroglial Degeneration ; Rat ; Abnormal Sterols
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Wistar strain of rats received daily intraperitoneal or oral administration of Triparanol, 250 mg per kg of body weight or 20,25-diazacholesterol either 30 mg or 60 mg per kg of body weight starting at the age of 5 days old. Prominent intracytoplasmic osmiophilic inclusions identical to those found in the rats treated with AY9944 (Suzukiet al., 1973) and degeneration of myelin sheaths and oligodendroglia were seen in the myelinating white matter of rats sacrificed after 3, 6, and 9 injections of Triparanol. In diazacholesterol-treated animals, a few identical inclusions were seen in the cortical neurons but only slight changes were seen in oligodendroglia. Biochemical analysis of the brains of the rats receiving Triparanol revealed a large accumulation ofΔ 7,24-cholestadiene-3β-ol and lesser amounts of desmosterol. The brains of the animals treated with diazacholesterol revealed massive accumulation of desmosterol and a minor sterol component, probablyΔ 5,7,24-cholestatriene-3β-ol. Since AY9944, which results in a massive accumulation of 7 dehydrocholesterol (Δ 5,7-cholestadiene-3β-ol) and two other sterols,Δ 7,24-cholestadiene-3β-ol andΔ 5,7,24-cholestatriene-3β-ol, will produce identical neuropathological lesions to those seen in Triparanol treated animals, and since the lesion produced in diazacholesterol treated animals was very slight, there appears to be a correlation between the presence of sterols with a double bond at the 7-position and neuropathological lesions in young rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684773
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  • 24
    Electronic Resource
    Electronic Resource
    The morphology of experimental tumours of the nervous system (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 25-32 
    Details
    ISSN: 1432-0533
    Keywords: Experimental CNS Tumours ; Nitrosomethylurea ; Ethylnitrosourea ; Primary Cultures ; Tumour Classification ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By means of the explant technique a series of primary tumours induced by methylnitrosourea (MNU) or ethylnitrosourea (ENU) in the brain of rats were cultured in vitro. The morphology of isomorphic oligodendrogliomas, astrocytomas, glioblastomas and sarcomas under in vitro conditions is described. All these neoplasias show a very distinct morphological picture and growth behaviour, thus permitting their classification. Most of the tumours tend to anaplastic changes during longer cultivation, but in some cases, preferably in well differentiated gliomas, the cytological properties are maintained even during longterm cultivation. The role of anaplasia and intermingling of different neoplastic cell types in experimental tumours are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687237
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  • 25
    Electronic Resource
    Electronic Resource
    Experimental allergic encephalomyelitis in the rat: Histopathological studies and the effects of sera on adult cerebellar organ cultures (1974)
    Springer
    Acta neuropathologica 27 (1974), S. 83-91 
    Details
    ISSN: 1432-0533
    Keywords: Allergic Encephalomyelitis ; Organ Culture ; Brain ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental allergic encephalomyelitis (EAE) developed in 15 of 30 rats injected with a mixture of Freund's adjuvant and homogenized guinea pig brain, and killed after 6–29 days. The incidence and severity of the disease increased with time after inoculation and in 2 animals involvement of the epiphysis, not previously reported in EAE, was detected. Toxic effects on cells in cultured adult rat cerebellar cortical tissue were produced by exposure for 24 h to the sera of rats killed 12–29 days after inoculation either with the antigenic suspension or with adjuvant alone. Severe toxicity to axons (widespread fragmentation) was produced only by the sera of animals injected with antigenic inocula and killed 17–29 days later. Severe axonal toxicity was not, however, correlated with the presence of EAE in the rats from which the sera were taken. It was not possible to assess myelinotoxic effects in the system used. It is suggested that the organ culture technique may detect the presence in the sera of inoculated animals of toxic principles which, owing to the blood-brain barrier, do not normally contribute to the pathogenesis of EAE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687243
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  • 26
    Electronic Resource
    Electronic Resource
    Ultrastructural alterations of rat brain microglial cells and pericytes after chronic lead poisoning (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 25-35 
    Details
    ISSN: 1432-0533
    Keywords: Chronic Lead Intoxication ; Rat ; Ultrastructure ; Microglia ; Pericytes ; Monocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Wistar rats of both sexes and the same litter were exposed to chronic lead intoxication from birth untill sacrifice 9 months later. Lead was administered as 0.4% solution of lead nitrate in drinking water. Samples from the parietal brain cortex were examined electron microscopically following intracardiac perfusion with paraformaldehyde-glutaraldehyde solution. Similar changes were observed in the microglial cells and the vascular pericytes whereas all the other tissue elements appeared intact. Both cell types hypertrophied, the microglia assumed characteristic spindle or rod shape, the cell organelles increased, the microglial endoplasmic reticulum widened strongly and a large number of lipid inclusions appeared. The latter consisted of large lipid droplets of varying size and shape, containing multiple zones of low density, and a dense component with a coarse granular structure. The similarity in the response of both cell entities to the lesion as well as some probable functions of microglial cells and their relationship to vascular pericytes are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687515
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  • 27
    Electronic Resource
    Electronic Resource
    The effects of sodium fluoride on bone breaking strength (1974)
    Springer
    Calcified tissue international 14 (1974), S. 283-289 
    Details
    ISSN: 1432-0827
    Keywords: Sodium fluoride ; Osteoporosis ; Bone ; Strength ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'utilisation thérapeutique de fluorure de sodium a été recommandée dans le traitement de diverses maladies osseuses ostéopéniques. Cet emploi est basé principalement sur les effects ostéosclérotiques bien connus du fluorure de sodium, mais on connait mal son effet sur la force de résistance osseuse. L'influence de diverses concentrations de fluorure de sodium sur la force de résistance osseuse de jeunes rats soumis à des régimes riches et pauvres en calcium a été étudiée. L'administration de fluorure de sodium augmente le diamètre osseux, indiquant une stimulation de la formation de l'os périosté, mais la force de résistance osseuse est réduite ou non modifiée par l'ingestion de fluor.
    Abstract: Zusammenfassung Die therapeutische Verwendung von Natriumfluorid ist für eine Anzahl von Knochenmangel-Krankheiten empfohlen worden. Die Empfehlungen basieren hauptsächlich auf den bekannten osteosklerotischen Wirkungen von Natriumfluorid; über dessen Effekt auf die Knochenstärke ist wenig bekannt. In dieser Arbeit wurde der Einfluß verschiedener Konzentrationen von Natriumfluorid auf die Knochenstärken von wachsenden Ratten mit hoher und niederer Calciumeinnahme untersucht. Die Verabreichung von Natriumfluorid erhöhte den Knochendurchmesser, was auf eine Stimulierung der Periostbildung hinwies, die Knochenstärke wurde jedoch durch Fluorideinnahme herabgesetzt oder nicht beeinflußt.
    Notes: Abstract The therapeutic use of sodium fluoride has been recommended in a variety of osteopenic bone diseases. The recommendations are based mainly on the known osteosclerotic effects of sodium fluoride and little information is available as to its effect on bone strength. The influence of various concentrations of sodium fluoride on bone strength in growing rats on high and low calcium diets was studied. The administration of sodium fluoride increased bone diameter, indicating stimulation of periosteal bone formation, but bone strength was reduced or not affected by fluoride ingestion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060302
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  • 28
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    Electronic Resource
    Function and interaction of on and off transients in vision II. Neurophysiology (1974)
    Springer
    Experimental brain research 19 (1974), S. 507-521 
    Details
    ISSN: 1432-1106
    Keywords: Cat ; LGN ; Transients ; Antagonistic inhibition ; Sensory storage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal responses to interruptions of light stimuli were studied in 58 X-type and 7 Y-type LGN relay cells with intra- and extracellular recording techniques. The responses to interruption were then compared with responses to either appearing or disappearing light stimuli which had the same luminance and size as the interrupted stimulus. The extent to which responses to interruption differed from those to appearance and disappearance was studied as a function of the interstimulus interval (ISI), the duration of the stimulus before the interruption (t1) and after the interruption (t2). Responses to stimuli appearing after interruptions of up to 500 msec were weaker than those to appearance and disappearance. This difference decreased with increasing ISI. The difference between responses to appearance and interruption increased as t2 decreased, and decreased as t1 decreased. The reverse was true for the difference between responses to disappearance and interruption. Stimulation of the mesencephalic reticular formation consistently reduced the difference between responses to appearance and disappearance compared with those to interruption for all stimulus conditions. These results are discussed in the context of the psychophysical study presented in the preceding paper. It is shown that the neuronal reactions are reflected in detail by the ability of humans to detect appearances and disappearances that occur during interruptions. EPSP sequences recorded from LGN relay cells and relay cell responses conditioned by reticular stimulation suggest that the differentiation of responses to interruption and change partially occurs already in the retina. This differentiation is subsequently enhanced by antagonistic inhibition in the LGN. It is proposed that these inhibitory interactions at peripheral sites of the visual pathway store visual information and serve to reduce the redundancy of responses to short interruptions of the visual input. Centrifugal modulation of LGN inhibition is proposed to control the trade off between temporal integration and temporal resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236114
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    Electronic Resource
    Reflexes in postganglionic fibres within skin and muscle nerves after noxious stimulation of skin (1974)
    Springer
    Experimental brain research 20 (1974), S. 125-134 
    Details
    ISSN: 1432-1106
    Keywords: Somato-sympathetic reflexes ; Cutaneous and muscle postganglionic neurones ; Noxious stimulation of skin ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Somomato-sympathetic reflexes in postganglionic neurones to skin and muscle induced by noxious stimulation of skin were studied in cats anaesthetized with chloralose. The reflexes were elicited by mechanical damaging stimuli and by temperature stimuli of more than 45°C. 2. In most cutaneous units the spontaneous activity was depressed during noxious stimulation of skin. Some cutaneous units were excited or showed mixed responses. The depression of the spontaneous activity was maximal from the skin area which was innervated by the cutaneous postganglionic neurones and much weaker or not elicitable from other skin areas. 3. Most muscle units were excited during noxious stimulation of skin. This excitation could be elicited from all over the body surface. 4. The effective cutaneous afferent fibres which are involved in these reflexes are the Group III axones which are excitable by mechanical damaging stimuli and the Group IV axones which are excitable by mechanical damaging and/or by thermal noxious stimuli. 5. These investigations reveal that the somato-sympathetic reflexes have opposite organization in cutaneous and muscle postganglionic fibres. The reflex patterns are discussed in relation to a possible central organization of the sympathetic nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234007
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  • 30
    Electronic Resource
    Electronic Resource
    Role of visual experience in the development of optokinetic response in kittens (1974)
    Springer
    Experimental brain research 20 (1974), S. 297-302 
    Details
    ISSN: 1432-1106
    Keywords: Cat ; Selective rearing ; Maturation ; OKN ; Perception of motion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Kittens reared in the dark from birth were exposed one hour a day between the 4th and the 10th week of age, to a visual environment which consisted exclusively of vertical edges moving horizontally at a constant speed, and always in the same direction. Total exposure time varied between 10 and 60 hours. 2. At the 12th week of age, optokinetic nystagmus (OKN) in response to displacements of the visual field, was tested. Displacements in the direction that the kittens had experienced during the exposure period elicited immediately an OKN, the frequency of which was related to the speed of the moving pattern. Displacements in the opposite direction elicited a poorer response, only for slowly moving edges. When the speed of the displacement was increased, OKN failed to adapt and finally disappeared. 3. These results suggest the existence, in this type of visuomotor behavior, of a component built up by early visual experience (adaptative component) overlying another component pre-existing visual experience (pre-programmed component).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238319
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    Electronic Resource
    Attention in the cat: Electrophysiological and behavioural studies (1974)
    Springer
    Experimental brain research 21 (1974), S. 67-82 
    Details
    ISSN: 1432-1106
    Keywords: Sensory transmission ; Lateral geniculate nucleus ; Visual cortex ; Attentive behaviour ; Vigilance ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behaviour of 6 cats was studied in a vigilance task. Each cat was trained to press a pedal on the floor of a training box. A waiting interval of fixed (FI) or variable (VI) duration then followed, after which a stimulus (S), a spot of light or a tone, was presented for a short period of time. The cat gave a correct response if, during this time, it pressed a panel. The animal was then rewarded with food. When an experiment had been completed using one S the cat was trained to respond to the other. The latency of response following the onset of S was measured for each waiting interval in the VI schedules. It was found that the longer latencies were associated with the shorter waiting intervals; that is, the cats responded more quickly to S as expectancy increased. Between the time the pedal and pand were pressed the optic tract (OT) was shocked not more than once and the response of the LGN and visual cortex recorded. The time at which the shock was delivered varied from 1 trial to the next. The responsiveness of the LGN and visual cortex did not vary during the waiting interval in either of the FI schedules or in the VI schedule in which S was a spot of light. However, in the VI schedule in which S was a tone, the responsiveness of the visual cortex to the thalamocortical input declined as the length of the waiting interval increased. No changes were observed at the LGN or in the presynaptic cortical response. These results contrast with those observed during changes in the level of arousal as assessed by the ECoG. When the ECoG passed from the synchronised to the desynchronised state there was an increase in the amplitude of the postsynaptic LGN response to the OT shock, but no change in the responsiveness of the cortex to the increased thalamocortical input. These changes in transmission in the visual pathways are discussed in relationship to the animal's behaviour and to the inferred state of attention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234258
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    Electronic Resource
    Special aspects of firing rates and thermosensitivity of preoptic neurons (1974)
    Springer
    Experimental brain research 21 (1974), S. 107-112 
    Details
    ISSN: 1432-1106
    Keywords: Preoptic units ; Thermosensitivity ; Mean firing rate ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mean firing rates (per 10 sec) of preoptic neurons of the rat were recorded at normal temperature and after central warming and cooling. Thermosensitivity was determined according to the reactions of the mean firing rate. In compatibility with results from other animals we obtained the following percentages (52 neurons): 23% warm-sensitive, 13% cold-sensitive, 64% non-thermosensitive neurons. However, it turned out that a lot of interesting special effects are not taken into account, using exclusively the criterion “increasing/decreasing/constant mean firing rate”. Particularly we observed long lasting adaption processes and stationary non-linear effects as well as striking oscillations which were dependent on the thermal stimuli, while the mean interval value remained constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234261
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    Electronic Resource
    Electrotonic coupling between motoneurones in the abducens nucleus of the cat (1974)
    Springer
    Experimental brain research 21 (1974), S. 139-154 
    Details
    ISSN: 1432-1106
    Keywords: Electrotonic coupling ; Antidromic responses ; Abducens motoneurone ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electrical stimulation of the abducens nerve provokes the classical true antidromic invasion of the abducens motoneurone and a depolarization which is often capable of generating full action potentials in the impaled motoneurone. Experiments studying these depolarizations suggest the existence of electrotonic coupling between the abducens motoneurones of the cat. Intracellular activity of the abducens motoneurones was recorded following intracellular stimulation of the impaled neurone and antidromic stimulation of the abducens nerve. Collision between the outgoing action potential and the antidromic volley differentiated the true antidromic spike from the depolarizations which can induce or not action potentials. The latency of the depolarization ranged between 100 and 1200 μsec. Collision demonstrated that the depolarization and the true antidromic action potential have an independent origin. The depolarizations and action potentials which are not conveyed to the motoneurone by its own axon are interpreted to be generated by electrotonic coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234386
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    Electronic Resource
    The lateral reticular nucleus in the cat I. Mossy fibre distribution in cerebellar cortex (1974)
    Springer
    Experimental brain research 21 (1974), S. 473-486 
    Details
    ISSN: 1432-1106
    Keywords: Lateral reticular nucleus ; Reticulocerebellar projection ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The areas of the cerebellar cortex receiving fibres from the mLRN (major portion of the lateral reticular nucleus comprising its parvi- and magnocellular parts) were determined by identifying the low-threshold spots on the cerebellar surface from which 286 mLRN neurones could be antidromically activated. 2. The mLRN fibres terminate bilaterally in the anterior lobe and pyramis, and ipsilaterally in the paramedian lobule. Some fibres terminate also in the rostral part of lobule VI but hardly any in other parts of the cortex. It follows that the mLRN projects almost exclusively to the classical spinal receiving areas. 3. Neurones in the parvi- and magnocellular parts project to similar cortical areas. 4. Two regions in the mLRN were distinguished on the basis of their different projection areas. Region A, a dorsolateral portion of the magnocellular part, projects to the ipsilateral parts intermedia of the anterior lobe and the ipsilateral paramedian lobule. Region B, a ventral portion of the parvi- and magnocellular parts, projects bilaterally to the pars intermedia and vermis of the anterior lobe and sparsely to the pyramis. 5. Neurones throughout the parvi- and magnocellular parts receive monosynaptic excitation from fibres ascending in the ventral part of the ipsilateral lateral funiculus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237166
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    Electronic Resource
    Vertical organization in the visual cortex (area 17) in the cat (1974)
    Springer
    Experimental brain research 21 (1974), S. 315-336 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex (area 17) ; Cat ; Columnar organization ; Retino-cortical scatter ; Intracortical connections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Responses of cortical cells in the cat's area 17 (central and paracentral area), recorded successively during electrode penetrations perpendicular to the surface, were averaged (PSTH). All cells recorded during one penetration were stimulated with the same stimulus, a slowly moving light or dark slit oriented optimally for the first cell recorded. Comparisons between successively recorded cells were completed by simultaneous recordings from two neurones with the same microelectrode tip. Eye movements as an error were excluded by simultaneous recording of a geniculate cell throughout a cortical penetration. 2. The centers of excitatory receptive fields (ERFs) of simultaneously or successively recorded cells during a penetration may be separated by more than 4°. The mean scatter around a column average is 0.81±0.99° in both directions. The scatter is independent of the recording depth. Whereas the optimal orientation of cells recorded during one penetration was generally similar, the optimal direction (forward and backward movement of an optimally oriented stimulus) was variable. 3. The ERF diameters as determined from the PSTH were between 〈0.5° and 7.5°. During each penetration, cells with small (up to 3.0°) and large (〉3.0°) ERFs could be discriminated. The inhibitory fields (determined with the conditioning method of Bishop, Coombs and Henry, 1971) were between 2.0 and 8.5° along both the optimal and the non-optimal orientation axis of a cell. The borders of inhibitory fields of cells collected during one penetration were also scattered though overlapping. 4. Response analysis of simultaneously and successively recorded cells with different stimuli indicated that, in spite of considerable ERF-overlap, cells with small ERFs had separate excitatory inputs and that intracortical excitatory connections between cells recorded during one penetration were improbable. 5. The ERFs of cells with large ERFs covered a field approximately corresponding to the fields of cells with small ERFs. But a convergent input from many small ERF cells to single large ERF cells was excluded because of the incompatible functional properties of both types of cells, which correspond to some extent to simple and complex cells respectively. 6. It is concluded that cells within cortical cylinders are not connected through excitatory contacts with each other and that most cells in area 17 are excited by individual excitatory geniculate or cortical inputs. Inhibitory connections seem to be the most important intracortical connections. 7. In an Appendix it is shown that anatomical and physiological data do not support significant excitatory convergence of specific geniculate afferents on cortical neurones.
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    URL: http://dx.doi.org/10.1007/BF00235750
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    The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 175-196 
    Details
    ISSN: 1432-1912
    Keywords: Intestinal Absorption ; Basic Drugs ; Amidopyrine ; Antipyrine ; Solvent Drag ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Jejunal loops of anaesthetized rats were perfused with hypotonic, isotonic and hypertonic buffered solutions containing 14C-labelled amidopyrine and antipyrine at neutral and at acidic pH. The blood flow of the loop was maintained at an intermediate rate (0.7–1.0 ml min−1g−1). The water net flux was determined by means of polyethylene glycol as non-absorbable marker and amounted up to ±30 μl min−1g−1. 2. A positive water net flux (directed towards the blood) increased the appearance rate of amidopyrine and antipyrine by maximally 43.8 and 49.2%, a negative water net flux (directed towards the gut lumen) diminished it by 38.8 and 35.0%. 3. The experimental data were analysed by means of a kinetic model with the water net flux as independent variable and the epithelial permeability kF D , the serosal permeability k S F S and the sieving coefficient Φ=1−σ as absorption parameters. For antipyrine independent of the pH-value of the perfusion solution kF D was 0.123, and, for amidopyrine at pH 7 and pH 3 kF D was 0.231 and 0.091, respectively. k S F S was zero indicating that in this experimental arrangement the transfer of drug molecules to the serosal side was negligible. The sieving coefficient Φ amounted to 2.30 for amidopyrine and 2.15 for antipyrine at neutral pH. At acidic pH it amounted to 0.50 for amidopyrine and 1.44 for antipyrine. The hydraulic permeability of water was identical at neutral and acidic pH. 4. The high sieving coefficient for the two drugs at neutral pH is interpreted as indicating that water and lipophilic drug molecules interact within the lipid part of the cell membrane. At acidic pH the ionized drug molecules appear to permeate the cell membrane preferentially across other (presumably more hydrophilic) areas.
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    URL: http://dx.doi.org/10.1007/BF00503497
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    The influence of blood flow on the phlorizine-insensitive and sensitive galactose absorption in rat jejunum (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 282 (1974), S. 195-212 
    Details
    ISSN: 1432-1912
    Keywords: Intestinal Blood Flow ; Intestinal Absorption ; d-Galactose ; Phlorizine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Jejunal loops of anaesthetized rats were perfused with buffered solutions (pH 6.8) containing d-galactose in two concentrations: below (100 μM) and above (100 mM) blood sugar concentration. The blood flow rate, the appearance rate (in the intestinal venous blood) and the disappearance rate (from the intestinal lumen) were determined simultaneously, the accumulation in gut tissue at the end of the experiments. 2. At constant intermediate blood flow the appearance rate and disappearance rate decreased with time. A decrease of the blood flow rate from about 1.9 to about 0.3 ml min−1 g−1 diminished both the appearance and the disappearance rate. An increase of blood flow from about 0.3 to about 1.9 ml min−1 g−1 did not increase the absorption rates; even a slight decrease was observed. 3. In the presence of phlorizine (2 mM) the absorption rates and the tissue accumulation of galactose is reduced. At constant intermediate blood flow the appearance and disappearance rate increased with time. A decrease of the blood flow rate from about 1.8 to about 0.3 ml min−1 g−1 diminished the appearance rate. An increase of the blood flow rate from about 0.3 to about 1.8 ml min−1 g−1 caused an increase of the appearance rate in contrast to the experiments without phlorizine. Therefore, the different blood flow dependence of the intestinal absorption observed with actively transported substances can be attributed to their non-passive component.
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    URL: http://dx.doi.org/10.1007/BF00499034
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    Fenfluramine-induced ultrastructural alterations in tissues of rats and guinea pigs (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 285 (1974), S. 175-184 
    Details
    ISSN: 1432-1912
    Keywords: Fenfluramine ; Rat ; Guinea Pig ; Phospholipidosis, drug-induced ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After administration of the anorectic drug fenfluramine (40 mg/kg per day) to rats (s. c. or i. p.) and guinea pigs (p.o.) over periods of 2 to 11 weeks, electron microscopic examination was performed on lungs, liver, lymphatic tissues and peripheral blood of both species, and on adrenal glands and ovaries of rats. In rats, fenfluramine caused the following alterations (listed according to the duration of treatment): Formation of abnormal lamellated inclusions in lymphocytes and plasma cells of lymphatic tissues, appearance of “foam cells” in lung alveoli; formation of abnormal lamellated inclusions in corpus luteum, lymphocytes of peripheral blood, and in adrenal cortex. In guinea pigs, the same alterations were found in lymphocytes of spleen and peripheral blood, in hepatocytes and in lung. The present observations support the concept of a generalized phospholipidosis induced by amphiphilic compounds. The potency of fenfluramine to induce a lipidosis is, however, considerably less pronounced than that previously demonstrated for the anorectic drug chlorphentermine. This difference is suggested to be due mainly to the lower degree of amphiphilia of fenfluramine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501152
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  • 39
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    The action of chlorpromazine on exploration in pairs of rats (1974)
    Springer
    Psychopharmacology 37 (1974), S. 249-254 
    Details
    ISSN: 1432-2072
    Keywords: Chlorpromazine ; Rat ; Social Interaction ; Exploration ; General Motor Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When two animals were placed in a hole-board the number of headdips made by each rat was twice the number made when tested alone, but was the same for pairs of drugged (2 mg/kg chlorpromazine) and undrugged rats, and for pairs where only one rat was drugged. This contrasts with the reduction of headdipping produced by chlorpromazine in single animals. However, chlorpromazine still reduced general motor activity, regardless of whether the partner was drugged or not. The activity of the undrugged rats was affected by the partner's state and was lower when the partner was drugged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421538
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  • 40
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    Electronic Resource
    Effects of low and high doses of l-Dopa on the tetrabenazine or α-methyltyrosine-induced suppression of behaviour in a successive discrimination task (1974)
    Springer
    Psychopharmacology 39 (1974), S. 199-212 
    Details
    ISSN: 1432-2072
    Keywords: Rat ; Successive Discrimination ; Conditioned Avoidance Response ; Nerve Impulses ; α-Methyltyrosine ; Tetrabenazine ; l-Dopa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of the administration of l-Dopa, 10 or 100 mg/kg i.p., on the α-methyltyrosine methylester HCl (α-MT; 250+50 mg/kg i. p.) or tetrabenazine (TBZ; 2 mg/kg i.p.)-induced suppression of a successive discrimination-conditioned avoidance task has been studied. It was found that administration of the high l-Dopa dose resulted in a reversal of the α-MT- or TBZ-induced suppression of the avoidance behaviour, although the discrimination was lost. Restoration of the avoidance behaviour and the correct discrimination was obtained with the low l-Dopa dose after α-MT but not after TBZ. The difference in the behavioural response to l-Dopa after α-MT as compared to the response obtained after TBZ is discussed in terms of the availability of the catecholamines formed from l-Dopa for release by the nerve impulses. Biochemical determinations of brain noradrenaline and dopamine were made in parallel. Further, a simple and reliable method for the aquisition of a successive discrimination in the rat is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421027
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  • 41
    Electronic Resource
    Electronic Resource
    Action of a new psychotropic drug (Sulpiride) on avoidance behavior in rats (1974)
    Springer
    Psychopharmacology 39 (1974), S. 309-314 
    Details
    ISSN: 1432-2072
    Keywords: Avoidance ; Drug ; Psychotropic ; Rat ; Sidman Schedule ; Sulpiride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a Sidman avoidance schedule. Doses ranging from 1 to 80 mg/kg resulted in the animal receiving fewer shocks. This effect was not correlated with an increase of responding and seemed unrelated to the suppressing action abruptly observed at high doses (i. e. 150 to 200 mg/kg). These results differ from those classicaly obtained with other neuroleptics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422970
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  • 42
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    Electronic Resource
    Behavioural and biochemical effects of 6-hydroxydopa in rats (1974)
    Springer
    Psychopharmacology 35 (1974), S. 341-352 
    Details
    ISSN: 1432-2072
    Keywords: 6-Hydroxydopa ; Rat ; Behaviour ; Biogenic Amines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of 6-hydroxydopa (6-HDP) injected into the lateral ventricles of rat brain on the behaviour of animals was examined. The level of noradrenaline (NA), 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete areas of the brain was also measured. 6-HDP was injected in a dose of 100 or 150 Μg into both lateral ventricles, or in a dose of 200 Μg into the right lateral ventricle. Immediately after 6-HDP injection, circling movements, convulsions, aggressive behaviour, and Stereotypic activity were seen. These components of behaviour were most obvious during the first hour after injection of 6-HDP. During one month after 6-HDP administration the behaviour of rats did not differ significantly from the behaviour of control animals, only very subtle differences in behaviour being seen. The dose of 150 Μg of 6-HDP caused aphagia and loss of body weigth during the first 5 days after treatment. 6-HDP also caused hypothermia. 20 min after administration of 200 Μg of 6-HDP a decrease of the NA level but no changes in the 5-HT level in the brain cortex were seen. The same changes were observed 1 month after 6-HDP treatment. The dose of 150 Μg of 6-HDP decreased the NA level in the brain cortex, cerebellum, mesencephalon and brain stem 5 days after treatment. 5-HT content was not changed and the 5-HIAA level was increased in the same brain areas. The dose of 100 Μg of 6-HDP, 2 weeks after the treatment decreased the content of NA in the brain cortex, cerebellum, hypothalamus and brain stem without changes in 5-HT content. 5-HIAA level was elevated only in the brain stem. It is concluded that 6-HDP is a long-acting potent depletor of NA in rat brain. There is a different sensitivity of brain areas to the depleting effect of 6-HDP. 6-HDP does not deplete the 5-HT content of discrete areas of brain but increases the level of 5-HIAA. 6-HDP causes distinct behavioural changes shortly after the treatment. It does not change the behaviour of rats between 1 and 30 days after its administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429225
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  • 43
    Electronic Resource
    Electronic Resource
    Conditioned aversion in spatial paradigms following methamphetamine injection (1974)
    Springer
    Psychopharmacology 36 (1974), S. 323-335 
    Details
    ISSN: 1432-2072
    Keywords: Methamphetamine ; Rat ; Conditioned ; Aversion ; Space ; Saccharin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three experiments were performed on Sprague-Dawley derived rats in which 3.0 mg/kg, i.p., injections of methamphetamine were paired with either, (1) a distinctive spatial enclosure, i.e., either a black or gray portion of a shuttle box with discriminably different flooring, (2) the enclosure plus 0.1% saccharin solution availability in the home cage, or (3) the enclosure plus 0.1% saccharin solution availability in that area. Following three drug pairings which alternated with saline injections paired with a different enclosure or enclosure plus H2O availability, a choice of either spatial (1), or spatial plus gustatory stimuli (2,3) which included the original CS's, were presented under non-drug, non-injection conditions. Control groups received saline injections each day under identical conditions. No aversion to the enclosed area, which had been paired with the drug was demonstrated under (1), gustatory (P=0.005) but not spatial aversion was in evidence in the second paradigm, and spatial (P=0.01) and gustatory (P〈0.01) aversion was exhibited in the last study. It was concluded that subsequent aversion to distinctive spatial enclosures following methamphetamine injections was not as strong an effect as similar aversions to gustatory stimuli. Furthermore, the effect only obtained to neutral and not to preferred spatial areas at the dose level tested and in the apparatus used in those studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422564
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  • 44
    Electronic Resource
    Electronic Resource
    In vivo studies on uricase activity in the rat (1974)
    Springer
    Pflügers Archiv 351 (1974), S. 323-330 
    Details
    ISSN: 1432-2013
    Keywords: Uricase ; Urate ; Allantoin ; Liver ; Kidney ; Microperfusion ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In vivo uricase activity was tested in rats by injection of 2-C14 urate and measurement of the total C14 activity and the fractional activities of allantoin, allantoic acid and urea in samples of blood and urine. In control animals, 5 min after the injection, 70% of the plasma tracer was already present in the form of allantoin. No allantoic acid and urea were produced. Intestinectomy had no measurable influence on uricase activity. On the other hand, hepatectomy or ligation of the hepatic artery combined with subtotal viscerectomy did abolish uricase activity almost completely. 2. Following microinjections into proximal tubules of Ringer solution containing 2-C14 urate, urine samples during early recovery mainly contained labelled urate, whereas in later samples the fraction of labelled allantoin increased. About 12 min after the microinjection the urine of both kidneys contained equal amounts of tracer mainly in the form of allantoin. 3. When segments of proximal tubules were perfused with an equilibrium solution containing tracer amounts of C 14 urate, no urate was metabolized during its passage through the proximal tubule. 4. C 14 urate was offered from the peritubular capillaries and samples of tubular fluid were analyzed, Again, all the tracer in the tubular fluid was in the form of urate, indicating that urate is not oxidized when it is transported across the tubular cell. It is concluded from these results that: 1. The rat kidney has no significant uricase activity. 2. Urate transport in the kidney is not influenced by this enzyme. 3. The degradation of urate to allantoin takes place at extrarenal sites, mainly in the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00593318
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  • 45
    Electronic Resource
    Electronic Resource
    Cardiac hypertrophy in the first generation of rats native to simulated high altitude (1974)
    Springer
    Pflügers Archiv 350 (1974), S. 241-248 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac Hypertrophy ; Diffusion Distance of Oxygen ; High Altitude ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In rats born and staying their whole life at a simulated altitude of 3500 m a severe cardiac hypertrophy develops which is most pronounced in the right ventricle. On histological sections muscle fiber and capillary densities were counted and the surfaces occupied by muscle fibers and capillaries in the slides were estimated. Mean muscle fiber diameter and half mean distance between capillaries (diffusion distance) were obtained in the heart ventricles and were compared with those of control animals. In both ventricles an increase of the mean muscle fiber diameter occurred (true hypertrophy), being more pronounced in the right ventricle. We cannot tell whether also hyperplasia of muscle fibers occurred or not. The diffusion distance in the left ventricle of rats exposed to hypoxia was about the same as in control animals but was shorter in the right ventricle. This indicates that the total number of capillaries is higher in both ventricles of rats born in the low pressure chamber (hyperplasia of the capillaries). The shortening of the diffusion distance in the right ventricle of rats born and living their whole life at simulated high altitude was on the average smaller than that of rats exposed to simulated high altitude later in life. The physiological importance of this observation is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587803
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  • 46
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    Electronic Resource
    Analysis of periodic components of hypothalamic spike-trains after central thermal stimulation (1974)
    Springer
    Pflügers Archiv 351 (1974), S. 13-24 
    Details
    ISSN: 1432-2013
    Keywords: Hypothalamus ; Spike-Trains ; Correlogram/Periodogram ; Thermosensitivity ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stationary spike-trains of preoptic neurons of the rat were submitted to a correlation- and spectral-analysis at normal temperature and after central warming and cooling. Correlograms and periodograms were computed which enable the elimination of stochastic signal components and the identification of the relevant periodic components. About one half of the analysed neurons showed periodic correlograms. The following three classes may be distinguished: Neurons which showed correlograms with periodicities at each applied thermal state, at only one or two thermal states and those with no recognizable periodicities at all. Relations between periodicity and the thermosensitivity of the neurons are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00603507
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  • 47
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    Electronic Resource
    The projection of the superior colliculus onto the reticular formation of the brain stem an experimental anatomical study in the cat (1974)
    Springer
    Experimental brain research 19 (1974), S. 1-19 
    Details
    ISSN: 1432-1106
    Keywords: Reticular formation ; Superior colliculus ; Cat ; Experimental anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following altogether 18 stereotactically placed lesions of different location and size in the superior colliculus the efferent fibres to the RF and their distribution were traced in silver impregnated, approximately serial sections (Nauta and Fink and Heimer methods), cut in the transverse, horizontal or sagittal plane. The projection to the mesencephalic RF was found to be almost completely ipsilateral, that to the pontomedullary RF largely contralateral. In the mesencephalic RF the fibres end in its dorsal half approximately. In the pons and medulla they supply only the medial 2/3 of the main RF, with two distinct maxima within the total field of termination. One maximum covers the rostral part of the nucleus reticularis gigantocellularis and the adjoining part of the nucleus reticularis pontis caudalis, the other occupies the rostralmost part of the latter and the caudal part of the nucleus reticularis pontis oralis. Of the precerebellar reticular nuclei the contralateral nucleus reticularis tegmenti pontis receives a distinct component of tectal fibres in a small area dorsomedially. Some fibres end in a restricted part of the nucleus reticularis lateralis and in the paramedian reticular nucleus. The tectoreticular projection appears to be organized according to the same principles as other afferents to the RF. In the main RF the areas of termination of the tectoreticular fibres coincide more or less with the areas of termination of corticoreticular, fastigioreticular and vestibuloreticular fibres. These common terminal areas are those which give off the bulk of reticulospinal fibres. Some functional implications of the pattern of organization in the tectoreticular projection are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233392
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  • 48
    Electronic Resource
    Electronic Resource
    Neuronal activity during eye movements in a visual association area of cat cerebral cortex (1974)
    Springer
    Experimental brain research 19 (1974), S. 467-477 
    Details
    ISSN: 1432-1106
    Keywords: Suprasylvian gyrus ; Cat ; Single neurons ; Eye movements ; Direction sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 270 single neurons from the anterior part of the middle suprasylvian gyrus (AMSS) were recorded in awake and non-paralyzed cats (Chronic preparation). 10% were unresponsive to visual stimulation, the remainder reacted well to moving visual stimuli. Half of the units tested were directionally selective. Horizontal, or downward preferred directions predominated. Most neurons were relative insensitive to changes of shape, orientation, contrast, and velocity of the visual stimulus. Some neurons preferred rapid (100°/sec) jerky movements, others required complex motions of irregular shapes, a few strongly preferred objects moving towards the animal in the midsagittal plane. 40% of neurons yielded phasic On-Off reaction to flashing stationary spots. Habituation to repeated stimulation was a common feature and occured in 50% of AMSS neurons. In 19% of neurons tested the discharge rate was not affected by saccadic eye movements, when the animal faced a patterned background. Among the remainder two types of saccade associated responses could be distinguished. Type I discharged prior to or simultaneously with the onset of saccades. This early response was usually associated with saccades of particular directions. Saccades in total darkness yielded weaker and less consistent responses. Type II discharged subsequent to the onset of the saccades after a latency of 40 msec (type IIa), 40–80 msec (type IIb) and 80 msec (type IIc). Responses of type IIa are probably consequences of the retinal effects of eye movements. The saccade associated responses of type Ia, IIb and IIc are tentatively interpreted as results of an eye movement-synchroneous subcortical input, which facilitates transmission in AMSS neurons. Presaccadic facilitation, which generates type Ia responses, may be functionally related to shifts of attention prior to eye movements. It is suggested that postsaccadic facilitation, which underlies the reactions of type IIb and IIc, may be a correlate of visual attention during the fixation period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236111
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  • 49
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    Electronic Resource
    The organization of projections from the cerebellar nuclei to the contralateral motor cortex in the cat (1974)
    Springer
    Experimental brain research 19 (1974), S. 36-60 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellar nuclei ; Motor cortex ; Evoked potentials ; Topographical organization ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. A topographical study of cerebello-cortical relations was conducted in cats anesthetized with chloralose. The potentials evoked by punctate stimulation of the cerebellar nuclei were recorded at various sites in the contralateral motor cortex. A map of the cortical responses obtained by stimulating each of the cerebellar nuclei was established. For this purpose, the stimulation thresholds as well as the response amplitudes, polarity and latency were noted. 2. Local stimulation of each cerebellar nucleus evoked responses in particular regions of the contralateral motor cortex. When a stimulus was applied to the interpositus nucleus, short latency responses were recorded in the lateral part of the area 4. Dentate nucleus stimulation induced short latency responses in the medial part of area 4 and in area 6. Furthermore, late responses were also recorded laterally in area 4. 3. The interpositus nucleus was found to project to the portion of motor cortical area controlling the distal forelimb with only a fast conducting pathway. The fastigial nucleus seems to be connected with proximal and axial motor areas. The projection system of the dentate nucleus appears to have a temporal organization: a fast conducting pathway was found to project to the axial and proximal motor area while a slower one seems to transmit impulses to the motor area of the forelimb extremity. 4. The functional aspects suggested by the temporal organization of the cerebellocortical inputs and the distribution of each nucleus projections on the motor cortical areas are discussed.
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    URL: http://dx.doi.org/10.1007/BF00233394
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  • 50
    Electronic Resource
    Electronic Resource
    Lack of fixed order of recruitment in cat motoneuron pools (1974)
    Springer
    Experimental brain research 20 (1974), S. 101-114 
    Details
    ISSN: 1432-1106
    Keywords: Size principle ; Motoneurons ; Cat ; Recruitment ; Neurophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Henneman et al. have shown that a wide variety of stimuli activate motoneurons in the order of their sizes, though some reversals occur. It is not clear which motoneurons should be included in the “pool” from which recruitment by size takes place. The “pool” may consist of 1. all the motoneurons to a given muscle 2. all the motoneurons in a given ventral root or 3. all the motoneurons activated by a given stimulus. We have examined recruitment in the pool of fibers to a given muscle. A variety of mechanical stimuli to cat's legs were used to elicit bursts of activity in gastrocnemius motor units. In 30% of pairs of units, one unit had a consistently lower threshold, i.e. it always began and ended a burst. In the other 70%, either unit could start or end a burst. For 48% of motor unit pairs recorded in either the medial or lateral gastrocnemius, each unit of the pair had runs of firing of at least 10 spikes while the other was totally inactive. By the same criterion, 23% of pairs of temporalis units showed differential activity. During spontaneous breathing there was no consistent recruitment order in 24% of pairs of units in throat respiratory muscles. These data indicate that reversals of recruitment order are relatively common for motoneurons innervating the same muscle. We discuss the possibility that size principle may hold for motoneurons in a single ventral rootlet whose somas are anatomical neighbors (even though they innervate different muscles), but not for motoneurons that are anatomically distant in the cord (even though they innervate the same muscle).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234005
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  • 51
    Electronic Resource
    Electronic Resource
    Effect of differential blocking of motor axons on antidromic activation of Renshaw cells in the cat (1974)
    Springer
    Experimental brain research 20 (1974), S. 135-143 
    Details
    ISSN: 1432-1106
    Keywords: Cat ; Renshaw cell ; Antidromic activation ; Differential blocking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Attempts were made to study differences in the relative effectiveness of different size ranges of motor axons to Renshaw cells by differential blocking of larger fibers of the gastrocnemius nerve in cats anesthetized with Nembutal. 1. Differential blocking of larger fibers in the nerve was successfully obtained by applying trapezoid wave current to the nerve. 2. It was shown that more than half (58.1%) of the Renshaw cells receive homogeneous inputs from a motor axon collaterals, 25.8% of the cell receive collateral inputs from a certain group of fibers, and 12.5% of the Renshaw cells were activated by “γ range” fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234008
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  • 52
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    Electronic Resource
    Reflexes in postganglionic fibres within skin and muscle nerves after mechanical non-noxious stimulation of skin (1974)
    Springer
    Experimental brain research 20 (1974), S. 115-123 
    Details
    ISSN: 1432-1106
    Keywords: Somato-sympathetic reflexes ; Postganglionic fibres to skin and muscle ; Natural stimulation of skin ; Hair-follicle receptors ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Somato-sympathetic reflexes in postganglionic neurones to hairy skin and to muscle produced by mechanical non-noxious stimulation of skin were studied in cats anesthetized with chloralose. Most of the postganglionic fibres investigated were spontaneously active and had presumably vasoconstrictor function. 2. In 60% of the cutaneous postganglionic neurones stimulation of hairs induced predominantly excitation. This excitation was mostly followed by a slight depression of the spontaneous activity. In 30% of the neurones the spontaneous activity was depressed or predominantly depressed by these stimuli. 3. In most muscle postganglionic neurones the spontaneous activity was depressed by stimulation of hairs. 4. In both types of neurones the reflexes were produced by activity in hair follicle receptors with Group II afferents. Hair follicle receptors with Group III afferents most probably also contributed to this effect. Except for a slight depression of the spontaneous activity in some cutaneous postganglionic neurones by slowly adapting receptors, mechanical stimulation of other types of receptors with Group II afferents had no effect on the postganglionic neurones. 5. Reflexes in postganglionic neurones could be elicited by stimulation of hairy skin all over the body surfaces.
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    URL: http://dx.doi.org/10.1007/BF00234006
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  • 53
    Electronic Resource
    Electronic Resource
    Demonstration by degeneration silver method of the ascending projection from the locus ceruleus (1974)
    Springer
    Experimental brain research 20 (1974), S. 181-192 
    Details
    ISSN: 1432-1106
    Keywords: Locus ceruleus ; Cerulo-cortical tract ; Ascending reticular fiber ; Rat ; Fink-Heimer method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to demonstrate the ascending projection from the locus ceruleus by degeneration silver method, the nucleus was destroyed unilaterally in rats and the brains were stained by a modified Fink-Heimer method following various survival times. Additional experiments included the bilateral destruction of the locus ceruleus and the administration of 6-OH-DOPA. For the demonstration of degenerated terminals in the cerebral cortex it is essential to choose an optimal survival time of 4 or 5 days, keep the time of fixation below 1 week, and perform treatments with permanganate and with silver at 37°C. The trajectory and distribution of the cerulo-cortical tract as revealed by the silver degeneration methods is in agreement with the results of the histofluorescence method, with some minor differences. The ascending fibers run through Forel's tegmental fascicle, turn rostro-ventrally to the subthalamus, enter and cross the internal capsule, pass through the ventral part of the caudate-putamen and distribute to the entire cerebral cortex. The tract is mainly ipsilateral, though some fibers are crossing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234012
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  • 54
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    Electronic Resource
    Projections thalamiques des noyaux vestibulaires: Etude histologique chez le chat (1974)
    Springer
    Experimental brain research 20 (1974), S. 273-283 
    Details
    ISSN: 1432-1106
    Keywords: Vestibular nuclei ; Thalamic projections ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electrolytic lesions were placed into the left vestibular nuclei of 22 adult cats. Silver impregnation for degenerated terminal fibres of serial sections revealed the existence of a relay of the corticopetal vestibular pathway in the contralateral thalamus. Its main afferent fibres originate in the superior and medial vestibular nuclei. By crosschecking the results it was possible to demarcate a focus of vestibular projections in the ventro-caudal part of the thalamus, situated between the centre median, the ventro-basal group and the caudal segment of the ventro-lateral nucleus. The direct ascending afferents of this focus are relatively few in number. The functional significance of this vestibular relay with regard to the proprioceptive influx passing through this region of the thalamus is open to discussion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238317
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  • 55
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    Electronic Resource
    Bilateral semicircular canal inputs to neurons in cat vestibular nuclei (1974)
    Springer
    Experimental brain research 20 (1974), S. 285-296 
    Details
    ISSN: 1432-1106
    Keywords: Ampullary nerve ; Cat ; EPSP ; IPSP ; Vestibular neuron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The six ampullary nerves in both labyrinths were separately stimulated by electric pulses in anesthetized cats. Resulting responses in neurons in the vestibular nuclei were recorded intracellularly. Almost all the vestibular neurons showed an EPSP in response to stimulation of the ipsilateral ampullary nerve. These neurons were subclassified as A-, L-, and P-neuron receiving specific projections from the anterior, lateral and posterior canal, respectively. Three fourths of the vestibular neurons recorded from received an IPSP in response to stimulation of the contralateral ampullary nerve. Plane-specific contralateral inhibition was found in most of vestibular neurons; i.e. A-, L-, and P-neuron received IPSP from the contralateral posterior, lateral, and anterior ampullary nerve, respectively. Approximately two thirds of vestibular neurons exhibiting the plane-specific inhibition were recorded in the medial vestibular nucleus. A collision test of impulses in primary afferent fibers were performed during recording of ipsilateral EPSPs produced by strong stimulation of more than one ampullary nerve. No positive evidence was provided for the existence of neural convergence on single vestibular neurons from different ampullary nerves on the same side. It is suggested that the plane-specific contralateral inhibition increase the sensitivity of vestibular neurons during head rotation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238318
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  • 56
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    Electronic Resource
    Responses of cat vestibular neurons to sinusoidal roll tilt (1974)
    Springer
    Experimental brain research 20 (1974), S. 347-362 
    Details
    ISSN: 1432-1106
    Keywords: Vestibular nuclei ; Tilt response ; Sinusoid ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Extracellular recordings were made in the lateral and inferior vestibular nuclei of decerebrate, unanesthetized cats. The firing patterns of single units were studied using small amplitude sinusoidal roll tilts of from 0.01 Hz to 1.0 Hz. Three-fourths of the tilt-sensitive units showed greater modulation of their firing rates as the frequency of the sinusoidal tilt was increased. The responses of cells in both nuclei were similar. These responses were virtually unchanged in cats with chronically plugged semicircular canals, indicating a probable otolith origin for the dynamics of the tilt response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237380
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  • 57
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    Electronic Resource
    Somatosensory cortical involvement in responses to noxious stimulation in the cat (1974)
    Springer
    Experimental brain research 20 (1974), S. 363-374 
    Details
    ISSN: 1432-1106
    Keywords: Pain ; Somatosensation ; Cerebral cortex ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The experiment examines the role of the cerebral cortex in regulating responses to noxious stimulation by studying the effects of cortical ablations in cats on escape from electric shock applied to the foot pads. The latency of escape as a function of shock intensity was measured before and after bilateral ablations of various portions of the cat's somatosensory cerebral cortex. Ablations of the second somatosensory cerebral cortex significantly increased the escape response threshold. If the sulci bordering this region were included in the ablation, the threshold increase was greater and longer-lasting. Ablations of the primary somatosensory cortex increased latencies at most intensities of electric shock, but did not change the response thresholds. Ablations of both primary and second somatosensory cortex increased response thresholds and response latencies. None of these ablations altered the responses, however, if the cat had been overtrained for six to seven months prior to surgery. The results suggest that the second somatosensory region and the sulci bordering the second somatosensory region in the cat cerebral cortex are involved in responses to noxious stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237381
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    An intracellular study of neuronal organization in the visual cortex (1974)
    Springer
    Experimental brain research 21 (1974), S. 45-66 
    Details
    ISSN: 1432-1106
    Keywords: Visual cortex ; Efferent cells ; Non-efferent cells ; Synaptic connection ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuronal connections in the visual cortex of cat (areas 17 and 18) were studied with intracellular recording and electrical stimulation techniques under Nembutal anaesthesia. Four types of axonal projection were seen; 1. association efferent cells projecting to adjacent cerebral cortex on the ipsilateral side, 2. commissural efferent cells to visual cortex on the contralateral side, 3. corticofugal efferent cells to the ipsilateral lateral geniculate body and superior colliculus, and 4. non-efferent cells whose projection is confined within the visual cortex. Both association and commissural efferent cells were located in layer III, corticofugal efferent cells in layer V and non-efferent cells in layers II–VI. Upon these cells two types of synaptic actions were exerted by the specific visual afferents that originate from the lateral geniculate body; 1. type I, monosynaptic excitation plus disynaptic inhibition and 2. type II, disynaptic excitation plus trisynaptic inhibition. Type I effects were found in layers III–V, and type II in layers II and VI. In the border region between areas 17 and 18 monosynaptic excitation and disynaptic inhibition were produced also by the commissural efferents originating from the contralateral visual cortex. On the basis of these results, a possible neuronal circuitry in the visual cortex is postulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234257
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    The lateral reticular nucleus in the cat III. Organization of component activated from ipsilateral forelimb tract (1974)
    Springer
    Experimental brain research 21 (1974), S. 501-513 
    Details
    ISSN: 1432-1106
    Keywords: Lateral reticular nucleus ; Spinoreticular tract ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The activation of neurones in the mLRN (major portion of lateral reticular nucleus comprising its parvi- and magnocellular parts) by two spinal tracts ascending through the ventral part of the lateral funiculus has been studied by recording from 277 neurones of which 187 could be antidromically activated by stimulation of the cerebellar surface. Forty-eight % of the neurones were activated by the bVFRT and described in a previous paper (Clendenin et al., 1975b) and 12% were activated by a previously unknown tract denoted the ipsilateral forelimb (iF) tract and described in the present paper. 2. The iF-tract is activated by stimulation of nerves in the ipsilateral forelimb only. The response consists of a train of impulses with a high initial frequency and an almost constant latency. Cutaneous afferents and high threshold muscle afferents contribute to the excitation which is mediated by interneurones. 3. The responses to stimulation of peripheral receptors were weak and difficult to classify. 4. The iF-tract activates neurones in the dorsolateral portion of the magnocellular part of the mLRN which projects to the ipsilateral pars intermedia of the anterior lobe and the ipsilateral paramedian lobule. 5. The possible information carried by the iF-tract is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237168
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    On the origin of the corticotectal projections in the cat (1974)
    Springer
    Experimental brain research 21 (1974), S. 433-439 
    Details
    ISSN: 1432-1106
    Keywords: Superior colliculus ; Visual cortex ; Layer V-pyramids ; Clare Bishop area ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stereotaxic injection of horseradish peroxidase into the superior colliculus produced retrograde labelling of layer V pyramides in the Clare Bishop area and the lateral bank of the suprasylvian sulcus, in area 17,18 and 19. Single labelled cells were also found scattered in the splenial, the suprasplenial, the lateral and the suprasylvian gyri. In the cruciate sulcus no labelled cells were observed. Autoradiographically, the lateral bank of the suprasylvian sulcus was also shown to give rise to fibres to the superior colliculus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237905
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    The lateral reticular nucleus in the cat II. Organization of component activated from bilateral ventral flexor reflex tract (bVFRT) (1974)
    Springer
    Experimental brain research 21 (1974), S. 487-500 
    Details
    ISSN: 1432-1106
    Keywords: Lateral reticular nucleus ; Bilateral ventral flexor reflex tract (bVFRT) ; Spino-reticulo-cerebellar path ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Neurones in the lateral reticular nucleus (LRN) activated by the bilateral ventral flexor reflex tract (bVFRT-LRN neurones) were identified by their responses to stimulation of fibres descending in the contralateral ventral quadrant of the spinal cord which activate the bVFRT neurones monosynaptically. 2. Eighty-eight of the 134 bVFRT-LRN neurones encountered could be antidromically activated at a low stimulus strength from small areas of the cerebellar surface assumed to represent cortical termination points. 3. The bVFRT-LRN neurones occurred throughout the parvi- and magnocellular parts of the LRN and terminated bilaterally in the anterior lobe and sparsely in the ipsilateral paramedian lobule and in the pyramis. 4. The responses evoked in the bVFRT-LRN neurones on stimulation of the contralateral ventral quadrant at C5 and L1 made it possible to estimate the approximate spinal level from which the bVFRT fibres originated. On this basis the bVFRT-LRN neurones were divided into cervical, thoracic, and lumbar groups receiving bVFRT afferents from mainly one spinal level and a convergence group receiving bVFRT afferents from several levels. 5. The different bVFRT-LRN groups received excitation from different combinations of nerves in the four limbs. 6. The cervical, thoracic and lumbar groups of the bVFRT-LRN neurones occurred in successively more ventrolateral portions of the LRN. 7. The cervical, thoracic and lumbar groups of the bVFRT-LRN neurones terminated in successively more rostral areas of the anterior lobe. 8. The organization of the bVFRT-LRN path is compared with that of the ventral and rostral spinocerebellar tracts. The possible function of the bVFRT-LRN path is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237167
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    Comparative study of the absorption, elimination and acute hepatotoxic action of ethanol in guinea pigs and rats (1974)
    Springer
    Archives of toxicology 32 (1974), S. 83-95 
    Details
    ISSN: 1432-0738
    Keywords: Alcohol, Ethyl ; Absorption ; Elimination ; Alcohol Oxidoreductases ; Hepatitis, Toxic ; Transaminases ; Glutamate Dehydrogenase ; Guinea Pig ; Rat ; Äthylalkohol ; Resorption ; Elimination ; Alkoholdehydrogenase ; Hepatotoxicität ; Transaminasen ; Glutamatdehydrogenase ; Meerschweinchen ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die maximalen Blutalkoholkonzentrationen nach oraler Gabe von 6,4 g/kg Äthanol in Form einer 40%igen Lösung (v/v) betrugen bei nicht nüchternen Meerschweinchen 6,8±0,3 mg/ml, bei nicht nüchternen Ratten dagegen nur 2,1±0,2 mg/ml. An nüchternen Tieren führte eine orale Alkoholbelastung von 4,8 g/kg zu maximalen Blutalkoholspiegeln von 6,3±0,2 mg/ml bei den Meerschweinchen und 3,7±0,3 mg/ml bei den Ratten. Intravenös injizierter Alkohol (1 g/kg) wurde demgegenüber von beiden Species mit der gleichen Geschwindigkeit eliminiert (275 mg/kg · Std), und die auf das Körpergewicht bezogene ADH-Aktivität der Leber war bei den Meerschweinchen um 20% größer als bei den Ratten. Die Resorption von Äthanol erfolgt somit bei Ratten erheblich langsamer als bei Meerschweinchen. Dies dürfte darauf beruhen, daß konzentrierte Alkohollösungen die Magenentleerung der Ratte stark verzögern. Niedriger konzentrierte Alkohollösungen werden von der Ratte schneller resorbiert; jedoch waren auch nach Gabe von 10%igem Alkohol die maximalen Blutalkoholspiegel bei Ratten noch um 36% niedriger als bei Meerschweinchen. Bei den Meerschweinchen waren nach oraler Gabe von 4,8 bzw. 6,4 g/kg Äthanol die Serumaktivitäten der GOT, GPT und GLDH erhöht; ein Anstieg der SGOT trat schon nach 1,6 g/kg Äthanol auf. Demgegenüber kam es bei Ratten nach 6,4 g pro kg Äthanol p.o. nur zu geringfügigen Aktivitätserhöhungen der Serumtransaminasen, während die Serumaktivität der GLDH unverändert blieb. Vacuolige Degeneration war das morphologische Substrat der durch Äthanol bei Meerschweinchen und Ratten ausgelösten Leberschädigung. Während diese Veränderung bei Meerschweinchen bereits nach einer Äthanoldosis von 1,6 g/kg auftrat, wurde sie bei Ratten erst nach 6,4 g/kg beobachtet. Schlußfolgerung: Das Meerschweinchen ist für Untersuchungen zur Toxicität von Äthanol besser geeignet als die Ratte.
    Notes: Abstract In fed guinea pigs, an oral dose of 6.4 g/kg of ethanol given as a 40% solution (v/v) produced a maximal blood alcohol level of 6.8±0.3 mg/ml, whereas in fed rats, blood alcohol levels after the same dose did not exceed 2.1±0.2 mg/ml. Maximal blood alcohol levels in fasted animals after an oral load of 4.8 g/kg of ethanol were 6.3±0.2 mg/ml in guinea pigs and 3.7±0.3 mg/ml for rats. However, i.v. injected ethanol (1 g/kg) was eliminated at the same rate in both species (275 mg per kg · h), and ADH activity of the liver related to body weight was by 20% greater in guinea pigs than in rats. Therefore, absorption of ethanol occurs at a much slower rate in rats than in guinea pigs. This is possibly due to the fact that high ethanol concentrations strongly delay emptying of the rat stomach. Lowering the ethanol concentration accelerates absorption rate in the rat. However, even after gavage of a 10% solution peak levels of blood alcohol were still lower by 36% in rats than in guinea pigs. In guinea pigs, increased serum activities of GOT, GPT, and GLDH occurred after an oral dose of 4.8 g/kg or 6.4 g/kg of ethanol, respectively. SGOT already increased after 1.6 g/kg of ethanol p.o. After 6.4 g/kg of ethanol given to rats serum transaminase levels increased only slightly, and GLDH activity not at all. Vacuolar degeneration was the morphological substrate of ethanol-induced liver damage in guinea pigs and rats. In guinea-pigs, it occurred already after 1.6 g/kg of ethanol, whereas in rats only after 6.4 g/kg. In conclusion, the guinea pig seems to be better suited for research on alcohol toxicity than the rat.
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    URL: http://dx.doi.org/10.1007/BF00316229
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    Resistance to extinction of an avoidance response in rats following the administration of chlordiazepoxide (Librium) or diazepam (Valium) (1974)
    Springer
    Psychopharmacology 38 (1974), S. 231-238 
    Details
    ISSN: 1432-2072
    Keywords: Rat ; Chlordiazepoxide ; Diazepam ; Extinction ; Avoidance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a one-way avoidance task with rats, injections of Librium (chlordiazepoxide) following avoidance acquisition resulted in prolonged resistance-to-extinction of the avoidance response. This effect occurred regardless of whether the rats had had prior experience with Librium or whether they were naive with respect to the drug. The same results were found with the same task when low doses of Valium were used. However, at a higher dosage an “extreme reaction” of either no responding or a high number of responses to extinction occurred in the naive animals. The Librium and Valium effects were compared to similar effects obtained using ethanol and hashish resin. These results indicate that the novelty hypothesis as originally stated by Amit and Baum cannot be supported because experience with the drugs prior to avoidance training did not attenuate the drug effect on avoidance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421375
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    Effect of LSD-25 and 1-methyl-d-lysergic acid butanolamide on rat brain and platelet serotonin levels (1974)
    Springer
    Psychopharmacology 36 (1974), S. 117-122 
    Details
    ISSN: 1432-2072
    Keywords: LSD-25 ; UML ; 5-HT ; Brain ; Platelets ; Behaviour ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Factorial analysis of rat cerebral 5-HT values observed following intraperitoneal LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) showed that the highly significant decrease induced by both drugs was independent of dose and that the effect of both drugs was the same. Increased platelet 5-HT values were also obtained with each drug. These findings suggest that the psychotomimetic effect of LSD-25 is not due to changes in cerebral 5-HT, since a relationship can probably be postulated between such an effect in man and the effect of LSD-25 on conditioned behaviour in the rat. It is also felt that the fact that these drugs decrease and increase cerebral and platelet values respectively may be of assistance in the interpretation of data relating to platelet 5-HT patterns in man under psychiatric conditions and during treatment with psychotropic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421783
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    Effect of acute and chronic ethanol administration on serotonin turnover in rat brain (1974)
    Springer
    Psychopharmacology 37 (1974), S. 91-100 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Brain Serotonin Turnover ; Tolerance ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In rats treated acutely and chronically with ethanol, brain serotonin (5-HT) turnover was determined by measuring in the same animals the rate of accumulation of 5-HT and the rate of decline of 5-hydroxyindoleacetic acid (5-HIAA) in the brain after administration of the MAO inhibitor pargyline-HCl. In the acute study, 5-HT turnover was not altered after a single 4 g/kg oral dose of ethanol. In two separate studies, it was shown that chronic administration of ethanol in the form of a liquid diet for 32 days also did not alter brain 5-HT turnover, even when the rats had developed a significant degree of tolerance to the motor-impairing effects of ethanol. These results suggest that tolerance to ethanol is unrelated to any change in brain 5-HT turnover.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00437416
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    Effets de la stimulation des fibres et des mécanorécepteurs splanchniques sur l'activité unitaire du cortex somesthésique (1974)
    Springer
    Pflügers Archiv 348 (1974), S. 127-137 
    Details
    ISSN: 1432-2013
    Keywords: Splanchnic Afferents ; G.I. and Peritoneal Receptors ; Cortical Projections ; Microelectrode Technique ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The experiments were performed on cats anesthetized with chloralose or Nembutal. The unitary activity of cortical neurons was recorded in the SI and SII areas by means of extracellular glass microelectrodes. The neurons showed frequently a spontaneous discharge (irregular or regular tonic discharge bursts of spikes). The electrical stimulation of contralateral splanchnic nerves produced different effects on a great number of the neurons: 1. early short activation, 2. late activation, 3. early and late complex activation, 4. partial or total inhibition of the spontaneous activity. These effects were obtained in the different cortical layers. Similar results have been observed by mechanical stimulation of the splanchnic receptors located in the gastro-intestinal tract and in the peritoneum. However in this case, the duration and the amplitude of inhibition and activation were generally weaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586475
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    Urate handling by the rat kidney (1974)
    Springer
    Pflügers Archiv 352 (1974), S. 115-120 
    Details
    ISSN: 1432-2013
    Keywords: Urate ; Reabsorption ; Loop of Henle ; Micropuncture ; Microperfusion ; Microinjection ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reabsorption rates for urate in the loops of Henle were measured in superficial nephrons in the rat 1. under conditions of free flow, 2. using microperfusion and 3. by a microinjection technique. 1. Under conditions of free flow distally measured TF/PUA/TF/PIn-values varied between 0.51 and 0.38 in antidiuretic rats, depending on TF/PIn (UA = both uric acid and urate, In = inulin, TF/P = concentration in tubular fluid to plasma concentration). The corresponding values in samples from end-proximal tubules were 1.06 and in urine 0.19 (U/PUA/U/PIn). 2. In microperfusion experiments of Henle loops early distal recoveries of 2-C14 urate varied between 57 and 86%, depending on the flow rates (10–40 nl/min). 3. In microinjection experiments C14 recovery in urine was about 85% when tracer solution was microinjected into endproximal tubules. From these results we conclude: 1. The main site of urate reabsorption is located in the loops of Henle. 2. This reabsorption is highly dependent on flow rates. Increase of flow rate through Henle's loop decreases urate reabsorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587510
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    Urate interaction with plasma proteins and erythrocytes (1974)
    Springer
    Pflügers Archiv 352 (1974), S. 121-133 
    Details
    ISSN: 1432-2013
    Keywords: Urate ; Protein Interaction ; Uptake by Erythrocytes ; Renal Reabsorption ; Man ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interaction of urate with human and rat plasma was studied by a dialysis technique at different temperatures. At 4° C a certain fraction of urate is bound to proteins. However, this fraction diminishes with increasing temperature and at 37° C only some 7–8% (in man) and 2% (in rat) interact with proteins. The finding that urate is almost completely filtered in the glomerulus is discussed. In body areas exposed to low temperatures protein binding of urate may be of importance. Urate uptake by erythrocytes is characterized by two components: a fast component equilibrating almost immediately at about 7% in man and 17% in rat and a slow component reaching equilibrium after 60 min, at 28% and 36%, respectively. The process is described by a mathematical formula. Lowering of the temperature mainly diminishes uptake by the slow component withQ 10-values ranging between 1.5 and 4.0. In the observed range of concentrations the uptake process does not saturate. The results at lower pH-values suggest that it is unionized uric acid which is transported by the slow component. Application of the data to kidney medulla supports the hypothesis that erythrocytes and, probably, to a lesser extent plasma proteins serve as vehicles for urate reabsorption in the countercurrent system. Such a temporary interaction enables uric acid to escape recirculation and to leave the kidney medulla.
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    URL: http://dx.doi.org/10.1007/BF00587511
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    The effects of scopolamine and physostigmine on fixed-interval behaviour in the rat (1974)
    Springer
    Psychopharmacology 39 (1974), S. 237-244 
    Details
    ISSN: 1432-2072
    Keywords: Antagonism ; Fixed Interval ; Scopolamine ; Physostigmine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this research was to determine if 2 drugs, scopolamine and physostigmine which have opposite effects on cholinergic transmission also produce opposite effects on fixed-interval (FI) performance. Scopolamine and a wide range of doses of physostigmine were administered singly and concurrently to a number of rats responding on a FI 2 min schedule. Scopolamine produced a disruption in FI curvature which could be antagonized by physostigmine, but physostigmine by itself produced no consistent change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421031
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    The role of sex and novelty in determining the social response to lithium chloride (1974)
    Springer
    Psychopharmacology 40 (1974), S. 91-99 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Social Behaviour ; Sex ; Novelty ; Photographs ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of lithium chloride on the social behaviour of male and female rats were measured in unfamiliar and familiar test situations using a photographic technique. Lithium-treated females showed an increase in body contact and a decrease in social distances in comparison with saline-treated controls in both test conditions. Males administered lithium showed increased corner occupancies in the novel test setting while in the familiar test they showed decreased body contact and increased average group social distance in comparison with the saline condition. Further tests in an exploration box confirmed that lithium decreased the general environmental responsiveness of male rats. The results are discussed with reference to the anti-aggressive effect of lithium.
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    URL: http://dx.doi.org/10.1007/BF00429450
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    Junctions in the central nervous system of the cat (1974)
    Springer
    Cell & tissue research 148 (1974), S. 577-586 
    Details
    ISSN: 1432-0878
    Keywords: Node of Ranvier ; Axonal-glial junctions ; Cat ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The paranodal zone of myelinated nerve fibers from the CNS of cats has been studied by means of the lanthanum technique and after freeze-etching. Special interest was given to the axonal-glial zones of contact in this region. Examination of the membranes of the paranodal pockets and the axolemma revealed that the membrane thickenings which occur between the adjacent membranes actually consist of bands. The bands show a specific pattern of diagonal running subunits 10 nm apart. These substructures of the axonal side of the membrane contacts protrude outwards, i.e. towards the glial membrane, where they fit into depressions on the glial membrane surface. This arrangement in form of a “zip-fastener” makes the whole structure very flexible. The subdivision of the bands was identified with both techniques. The different membrane aspects obtained by the freeze-etching technique are discussed in respect to the splitting theory, and a hypothetical model of this membrane specialization is presented.
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    URL: http://dx.doi.org/10.1007/BF00221941
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    In vitro analysis of the cellular localization of luteinizing hormone releasing factor (LRF) in the basal hypothalamus of the rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 371-378 
    Details
    ISSN: 1432-0878
    Keywords: LRF ; Hypothalamic localization ; Rat ; Ependyma ; Glia ; Light and electron microscopic Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Light and electron microscopic autoradiographic analysis of the medial basal hypothalamus of rat brains incubated for 30 and 60 minutes in tritiated luteinizing releasing factor (3H-LRF) revealed selective uptake in the form of silver grains over specialized ependyma (tanycytes) and perivascular glial cells in the palisade-contact zone of the median eminence. The functional capacity of tanycytes and glia are discussed in light of these data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226771
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    Electron microscopic investigation of synaptic organization of the trochlear nucleus in cat (1974)
    Springer
    Cell & tissue research 150 (1974), S. 409-423 
    Details
    ISSN: 1432-0878
    Keywords: Synaptic organization ; Trochlear nucleus ; Cat ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two distinct types of neuron in the cat trochlear nucleus (one large, one small) are described, the α- and γ-motoneurons, respectively. Four types of terminals are observed which establish axo-dendritic synapses. Two of them (Types I and II) perform axo-somatic synapses as well. Terminals en passant (Types I and II) are predominant. The Type I terminal is long and slender with a characteristic distribution of the axoplasmic organelles and the unique feature of a relative narrowing of the synaptic cleft as compared to the width of the neighboring extracellular space. Its vesicle population is pleomorphic and a conspicuous glial barrier surrounds the synaptic zones. The Type II terminal differs slightly from Type I, revealing a wider synaptic cleft and lacking a characteristic distribution of the axoplasmic organelles. The type III terminal is rarely observed performing axo-somatic synapses, but is a common finding in the neuropil. Post-junctional dense bodies are often present in its axodendritic synapses. The Type IV nerve terminal performs axo-dendritic synapses and is characterized by a rich content of large granulated vesicles. Axo-axonal synapses are observed only very rarely. The synaptic organization of the feline trochlear nucleus is compared with the synaptic morphology of the oculomotor nuclei of inframammalian species (Waxman and Pappas, 1971). In addition to certain similarities (e.g., richness of synapses en passant), significant differences are encountered: the present study provides no morphological evidence for electrotonic transmission in the trochlear nucleus of cat.
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    URL: http://dx.doi.org/10.1007/BF00220147
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    Failure to demonstrate serotonergic neurons in the myenteric plexus of the rat (1974)
    Springer
    Cell & tissue research 150 (1974), S. 493-496 
    Details
    ISSN: 1432-0878
    Keywords: Serotonin ; Neurotransmitter ; Myenteric plexus ; Rat ; Histofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Several recent studies suggested that serotonergic neuron-like elements are present in the guinea pig ileum. The present paper reports an extensive study of the digestive tract of the rat with the use of a histofluorescence technique. Administration of the serotonin precursor, tryptophan, associated with a monoamine oxidase inhibitor, did not allow histochemical demonstration of rapidly fading, yellow fluorescent, 6-hydroxydopamine-resistant neurons; conversely such neurons were readily detected in the brain. It is concluded that serotonergic neuron-like elements cannot be detected histochemically in the rat myenteric plexus area after chemical sympathectomy.
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    URL: http://dx.doi.org/10.1007/BF00225972
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    Studies on the juxtaglomerular apparatus (1974)
    Springer
    Cell & tissue research 151 (1974), S. 457-469 
    Details
    ISSN: 1432-0878
    Keywords: Juxtaglomerular apparatus ; Rat ; Adrenalectomy ; Renin and secretory granules ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Reaktion des juxtaglomerulären Apparates auf Adrenalektomie wurde untersucht. Im Stadium der Nebenniereninsuffizienz, sechs Tage nach der Operation, wurde quantitativ morphometrisch eine Abnahme der Volumendichte der Sekretgranula (von 32% auf 16%) festgestellt. Golgi-Apparat und Ergastoplasma proliferieren stark, wobei insbesondere die erweiterten Cisternen des Ergastoplasmas auffallen.
    Notes: Summary The response of the Juxtaglomerular apparatus to bilateral adrenalectomy was studied in rats. After the sixth postoperative day, symptoms of severe adrenal insufficiency had developed. In the Juxtaglomerular cells, the volume density of the secretory granules decreased from 32% to 16%. The Golgi apparatus and rough endoplasmic reticulum underwent considerable proliferation, the latter showing strikingly enlarged cisternae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222991
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    Some observations on the ultrastructure of the central amygdaloid nucleus in the cat (1974)
    Springer
    Cell & tissue research 151 (1974), S. 489-498 
    Details
    ISSN: 1432-0878
    Keywords: Limbic system ; Cat ; Amygdaloid body ; Light and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present study was undertaken to re-examine the central nucleus of the cat in Nissl stained sections, to describe its fine structural characteristics, and to compare the lateral subdivision of this nucleus with the putamen. In Nissl preparations, it was observed that the lateral subdivision of the central nucleus contains a fairly homogeneous population of small cells while the putamen contains both small and large cells. It is the presence of a few large cells at the lateral periphery of the lateral part of the central nucleus that makes the boundary between the two nuclei indistinct. Examination of the fine structure of the medial and lateral subdivisions of the central nucleus revealed the presence of many boutons containing flattened vesicles and fewer with spheroid vesicles. In contrast, most of the boutons in the putamen have spheroid vesicles. It is concluded that the lateral subdivision of the central nucleus may be distinguished from the putamen, except at its most lateral border, by its homogeneous population of small cells and its many boutons containing flattened vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222994
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  • 77
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    Electronic Resource
    Sex differences in adrenocortical structure and function (1974)
    Springer
    Cell & tissue research 151 (1974), S. 525-536 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Rat ; Sex differences ; Gonadal hormones ; Karyometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Adrenal glands of adult female rats are heavier than the glands of corresponding male rats. Postpubertal orchiectomy increases the adrenal weight, an effect restored by testosterone replacement. Under the same conditions ovariectomy of 8 weeks duration does not change the adrenal weight while estradiol replacement enhances the relative adrenal weight. Karyometric studies have shown that nuclei in the female zona fasciculata cells are larger (app. 18%) than those of the male. Similar but only slight differences (2%) were observed in the zona reticularis. Orchiectomy results in enlargement of cell nuclei within all zones of the adrenal cortex; testosterone replacement has the opposite effect. Ovariectomy of 8 weeks duration slightly enhances the volume of nuclei of the zona glomerulosa cells, has no effect on the nuclei of the zona fasciculata and reduces the volume of nuclei in the zona reticularis. Estradiol replacement reduces the volume of nuclei of the zona glomerulosa cells but increases nuclear volume in the zona fasciculata and in the zona reticularis. Thus testosterone has an inhibitory effect on the adrenal cortex of the rat while the physiologic effect of estradiol on the morphology of this gland, particularly on the zona fasciculata cells is rather dubious. The author wishes to thank Mrs. B. Westerska and Miss K. Siejak for excellent technical assistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222997
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  • 78
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    Electronic Resource
    Sex differences in adrenocortical structure and function (1974)
    Springer
    Cell & tissue research 151 (1974), S. 537-547 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Rat ; Sex differences ; Gonadal hormone ; Stereologic studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Adult female rats have heavier adrenals than males. Orchiectomy increases the adrenal weight, an effect reversed by testosterone. Neither ovariectomy nor estradiol replacement has an effect on absolute adrenal weight. The stereologic analysis of the volume fractions of particular adrenocortical zones have shown that the volume fraction of the zona glomerulosa in females is smaller as compared with males. On the contrary, the volume fractions of the fasciculata and reticularis zones are higher in female than in male rats. In both sexes gonadectomy and gonadal hormone replacement has an effect on the volume fractions of particular adrenocortical zones, these changes being more pronounced due to orchiectomy or testosterone replacement. The adrenal cortex of all experimental groups contains a similar quantity of parenchymal cells. The cytoplasm volume of a single adrenocortical cell is higher in all zones of the female adrenals as compared with the male. Orchiectomy increases the volume of the cytoplasm in fasciculata and reticularis cells. This effect was reversed by testosterone. Neither ovariectomy nor estradiol replacement has an effect on the volume of the cytoplasm in the fasciculata and reticularis cells. These studies have shown that sex differences with regards to rat adrenal size and weight depend upon the “physiologic atrophy” of the male adrenal cortex, while neither ovariectomy (8 weeks after operation) nor estradiol replacement has a conspicuous effect on the morphologic changes of this gland.
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    URL: http://dx.doi.org/10.1007/BF00222998
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  • 79
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    Electronic Resource
    Ultrastructural investigations of the palisade-shaped nerve fiber terminals of the normal hairs of rat's snout (1974)
    Springer
    Cell & tissue research 147 (1974), S. 259-269 
    Details
    ISSN: 1432-0878
    Keywords: Nerve endings ; Hair ; Rat ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Palisade-shaped nerve endings of the small normal hairs of the rat snout were examined with the electron microscope (fixation by perfusion). The terminals are located inside the ‘glassy membrane’ in the area of the neck of the hair root. The 10–20 radially arranged terminal axons are in direct contact with the basement membrane of the epithelium of the external root sheath. The axons are surrounded on all sides by leaf-shaped processes of the Schwann cells. The surfaces of these cell processes are marked by numerous vesicle-like invaginations (approx. 1000 Å dia.). Transverse sections from several areas of the palisadeshaped nerve endings are compared with longitudinal sections. In the upper area ‘empty’ vesicles (approx. 500–600 Å in diameter) occur, along with electron-dense vesicles (approx. 800–1100 Å in diameter); in the middle area, the axons are distended and contain accumulations of mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582800
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  • 80
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    The parietal layer of bowman's capsule in experimental hypertension (1974)
    Springer
    Cell & tissue research 147 (1974), S. 183-190 
    Details
    ISSN: 1432-0878
    Keywords: Kidney ; Rat ; Bowman's capsule ; Experimental hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The parietal layer of Bowman's capsule was examined in the rat in control animals and in animals made hypertensive by treatment with desoxycorticosterone acetatesaline and by clipping of the renal artery. At an early stage of elevation of blood pressure and, occasionally, prior to elevation of blood pressure, the epithelial cells of this layer showed basal cytoplasmic protrusion and reduplication accompanied by an increase in the thickness of the basement membrane. These changes preceded evidence of glomerular or renal arteriolar pathology. They presumably reflect either a response of this layer to increased blood pressure and modified glomerular function, or a direct effect of the factors that also induces blood pressure elevation. In either case, they imply a greater functional significance for the parietal layer than has usually been attributed to it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582793
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  • 81
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    The ultrastructure of the accessory sex organs of the male rat (1974)
    Springer
    Cell & tissue research 148 (1974), S. 57-67 
    Details
    ISSN: 1432-0878
    Keywords: Prostate ; Rat ; Cyproterone ; Alterations ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The dorsal lobe and the coagulating gland of the rat prostate were studied after administration of the anti-androgenic compound Cyp A for varying periods (7–20 days). There was a general involution of the organs with macroscopic atrophy and reduced amount of secretory material. Ultrastructurally the cells were pale, contained less organelles as compared with the controls, loss of cytoplasm and reduction both of cell height and width. The major changes also included reduction of the Golgi area, the rough endoplasmic reticulum and the number of free ribosomes. Within the dorsal lobe prominent nuclear changes were found, comprising different types of intranuclear inclusions of membranous configurations. The alterations observed in the present study are similar to the changes which were found in castrated animals and are consistent with atrophy. The results are discussed in relation to the available biochemical and autoradiographic data on the different lobes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224318
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  • 82
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    Electronic Resource
    Junctions in the central nervous system of the cat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 121-135 
    Details
    ISSN: 1432-0878
    Keywords: Astrocytic membranes ; Cat ; Orthogonal particle-complexes ; Freeze-etching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fixed and unfixed astrocytic membranes from the CNS of the cat were studied by means of the freeze-etching technique. A variable number of gap junctions was detected in astrocytic membranes. They are characterized by the well known hexagonal composition of their subunits. Besides this type of highly ordered membrane-bound particles, a second one was found. It is composed of four single particles (diameter 5 nm) which form an orthogonal subunit with a side length of about 10 nm. These membrane-associated orthogonal particle complexes (MOPC) could be observed in different stages of aggregation and expansion. They reveal an accumulation in membranes of the marginal glia layers and in the perivascular astrocytic end-feet. Unfixed, glycerol treated membranes, however, do not show these structures. After glycerol treatment of the unfixed membranes by immersion, the MOPC disintegrate to single particles which form clusters of various extension. The clustering phenomenon is dependent on the length of the time of exposure to glycerol. Shortening of the glycerol treatment by intravasal perfusion of the cryoprotectant agent causes an decrease of the clusters. Fragments and transient forms of the MOPC become visible. By variation of different physico-chemical parameters of the washing solution a similar effect on the MOPC was not achieved. The discussion deals with probable functional aspects of the MOPC. They are considered to act as membrane-bound functional multienzyme complexes which a) might play a role in mediating transmembrane passage of metabolites, or b) are essential for CSF control mechanisms, or c) have a functional relation to the nexus.
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    URL: http://dx.doi.org/10.1007/BF00209055
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  • 83
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    Ultrastructure of mucosal mast cells in normal and compound 48/80-treated rats (1974)
    Springer
    Cell & tissue research 150 (1974), S. 95-105 
    Details
    ISSN: 1432-0878
    Keywords: Mucosal mast cells ; Rat ; Compound 48/80 ; Degranulation, Release ; Light microscopy ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mast cells in the tongue and lamina propria of the duodenal mucosa, representing two cell types with different morphological, histochemical and functional properties have been studied under the electron microscope. Both cell types were found to contain similar moderately electron dense and homogeneous granules surrounded by a tight membrane constituting the basic ultrastructural characteristics of mast cells. The mucosal mast cells, however, contained fewer granules per cell and the individual granules often exhibited considerable variation in size. In addition the mucosal mast cells, unlike those of the tongue, peritoneum and skin, had a smooth plasma membrane lacking microvilli and possessed irregularly shaped or lobulated nuclei. In the tongue mast cells, administration of Compound 48/80 caused the formation of vacuoles around the granules, expulsion of granules from the cells and disintegration of the granular matrix, but no changes that could be attributed to 48/80 could be found in the mucosal mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220383
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  • 84
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    Electronic Resource
    Nerve endings in the arteria centralis retinae (1974)
    Springer
    Cell & tissue research 150 (1974), S. 143-145 
    Details
    ISSN: 1432-0878
    Keywords: Arteria centralis retinae ; Cat ; Innervation ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Terminal axons emerging from the inner plexiform layer of the cat retina reach the wall of the arteria centralis retinae, as revealed by electron microscopy. Numerous unusually large dense core vesicles (about 1000 Å in diameter), of different electron densities, occur in the varicosities of these axons. These observations may be compatible with the idea of an innervation of the central artery of the retina which is non-autonomic, possibly intrinsic in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220387
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  • 85
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    Kinetics of gametogenesis (1974)
    Springer
    Cell & tissue research 154 (1974), S. 443-470 
    Details
    ISSN: 1432-0878
    Keywords: Oocytes and T-prospermatogonia ; Rat ; Quantitative analysis ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Bei der Ratte findet die sexuelle Differenzierung der Gonade zwischen dem 14. und 15. Tag post conceptionem (p.c.) statt. Während dieser Zeit teilen sich die Oogonien und deren Parallelpopulation—die M-prospermatogonien (multiplying prospermatogonia) oder I-Gonocyten—sehr häufig. Um den 17. Tag p.c. tritt die letzte Generation der Oogonien bzw. der M-prospermatogonien in die Mitose. Die Mitosen bilden häufig “synchronisierte Gruppen”. Die postmitotischen Kerne ihrer Tochterzellen—der Oocyten und der T 1 prospermatogonien (primary transitional prospermatogonia) oder II-Gonocyten—sind klein. Ihr Chromatin ist in Form gröberer Schollen der Kernmembran angelagert. Auf diese Weise kommt das typische “krustenförmige” Aussehen bzw. die Ähnlichkeit mit den Prophasen der Oogonien und M-prospermatogonien zustande. Die Oocyten durchlaufen zunächst die G1-phase (etwa 10 Std Dauer) und treten dann—am Ende des Präleptotänstadiums—in die S-phase. Dann passieren sie die verschiedenen Stadien der meiotischen Prophase und treten vom 3. Tag post partum (p.p.) ab in das Dictyotänstadium. Die T1-prospermatogonien hingegen befinden sich etwa 10 Tage lang in der G1-phase, ohne wesentliche morphologische Veränderungen aufzuweisen. Vom 4. Tag p.p. an durchlaufen sie die S-Phase. Die S-Phasen-Dauer (D-S) beider Zellarten beträgt 11.5 Std und wurde durch Doppelmarkierung mit 14C- und 3H-Thymidin bestimmt. Als am besten geeignete Termine für die Bestimmung der D-S erwiesen sich bei den Oocyten der 18. Tag p.c. und bei den T1-prospermatogonien der 5. Tag p.p. Zu diesen beiden Zeitpunkten war die Anzahl der in die S-phase ein-und austretenden Oocyten bzw. T1-prospermatogonien gleich, die Zellen in S-phase befanden sich im “steady state”. Das Kernvolumen der Oogonien und M-prospermatogonien ist etwa doppelt so groß wie das der postmitotischen Oocyten und T1-prospermatogonien. Bis zum 5. Tage p.p. nimmt das Kernvolumen der Oocyten und T1-prospermatogonien um etwa das Fünffache zu. Der Degenerationsindex der Oocyten liegt wesentlich höher als der der T1-prospermatogonien; er ist postnatal besonders hoch. Aus den T1-prospermatogonien gehen am 4. und 5. Tage p.p. durch Teilung die T 2-prospermatogonien (secondary transitional prospermatogonia) hervor. Die Kerne dieses Zelltyps sind etwas kleiner also die der T1-prospermatogonien. Die T2-prospermatogonien treten am 6. Tage p.p. in die Mitose; es entstehen die ersten A-spermatogonien.
    Notes: Summary In the rat (Wistar-WU) sexual differentiation of the gonads occurs between days 14 and 15 post conception (p.c.). At this time the oogonia and their parallel population — the M-prospermatogonia (I-gonocytes)—divide rapidly. On about day 17 p.c., the last generation of oogonia and M-prospermatogonia, frequently arranged in synchronized clusters, enters mitosis. The postmitotic nuclei of their daughter cells—oocytes and T 1-prospermatogonia (II-gonocytes)—are small; coarse flakes of chromatin are associated with the nuclear membrane causing the typical “crustlike” appearance and the similarity with the prophases of oogonia and M-prospermatogonia. After the oocytes have passed a G1-phase of approximately 10 hr, they enter the S-phase at the end of the preleptotene stage. Then they pass the different stages of the meiotic prophase until they enter the dictyate stage from 3 day post partum (p.p.) onwards. The T1-prospermatogonia, on the other hand, spend a long G1-phase of about 10 days without any conspicuous morphological change before entering the S-phase from day 4 p.p. onwards. The duration of the S-pbase (D-S) of both cell types—oocytes and T1-prospermatogonia—as determined by the double labeling method with 14C- and 3H-thymidine is found to be 11.5 hr. The most favourable time for determining the D-S was day 18 p.c. for the oocytes and day 5 p.p. for the T1-prospermatogonia. On these two days the balance was reached between the cells entering and leaving the S-phase. The nuclear volumes of the postmitotic oocytes and T1-prospermatogonia are approximately half the size of those of their precursors. Until day 5 p.p. the nuclear volumes of the oocytes and T1-prospermatogonia increase about fivefold. The degeneration index of the oocytes is considerably higher than that of the T1-prospermatogonia; postnatally it is especially high. T 2 prospermatogonia arise by mitosis of the T1-prospermatogonia on day 4 and 5 p.p. The nuclei of this cell type are smaller than those of T1-prospermatogonia. T2-prospermatogonia enter mitosis on day 6 p.p and give rise to A-spermatogonia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219667
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    Development of serotonin-containing cells and the sympathetic innervation of the habenular region in the rat brain (1974)
    Springer
    Cell & tissue research 155 (1974), S. 231-243 
    Details
    ISSN: 1432-0878
    Keywords: Pinealocyte-resembling cells ; Habenular region ; Sympathetic nerve fibres ; Ontogenetic development ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The cells of the pineal gland, the pineal stalk, and the lamina intercalaris contain 5-HT and are innervated by sympathetic nerve fibres. These peripheral nerve fibres continue rostrally from the lamina intercalaris and run into the central nervous tissue of stria medullaris and the habenular nuclei. Pharmacological treatment to increase the cellular 5-HT content revealed that the sympathetic fibres are in close relation to yellow fluorescent cells embedded in the brain tissue. These yellow fluorescent cells develop very late in the ontogenetic development (three weeks or more postnatally) and are preceded by ingrowth of sympathetic fibres into the brain tissue. The results support the hypothesis that the cells found in the habenular region are of pinealocyte rather than neuronal nature, but it is possible that they differ in certain aspects from the cells of the pineal gland proper.
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    URL: http://dx.doi.org/10.1007/BF00221357
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  • 87
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    Electronic Resource
    Somatic spines in the supraoptic nucleus of the rat hypothalamus (1974)
    Springer
    Cell & tissue research 148 (1974), S. 203-211 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamus ; Rat ; Supraoptic nucleus ; Ultrastructure ; Somatic spines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopic studies of ultrathin serial sections of the perikarya and adjacent neuropil of neurons of the supraoptic nucleus (SON) of the adult male rat revealed varying forms of two types of somatic spines. One type forms synapses with axons passing the cell, the other, without synapses, appears to serve as a buttress or clasp for adjacent neuronal and glial processes. The synapse-bearing spines lack the usual spine apparatus but contain the flocculent substance often seen in spines. The other spines do not exhibit either of these structures. These somatic spines were also seen in Golgi impregnated preparations but the types could not be distinguished. Certain axons synapse either on a somatic spine of the perikarya or penetrate the glial sheath of the neuron and synapse, usually repeatedly, on the soma in an en passant manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224582
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  • 88
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    Ultrastructure of rat pineal gland after preparation by Freeze-etching technique (1974)
    Springer
    Cell & tissue research 148 (1974), S. 371-379 
    Details
    ISSN: 1432-0878
    Keywords: Pineal gland ; Rat ; Electric coupling areas ; Freeze-etching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The pineal glands of Wistar rats were fixed in glutaraldehyde and prepared by the freeze-etching technique. With regard to the form and internal structure of pineal cells this technique has revealed nothing essentially new. Synaptic ribbons are very rarely found. A regular diagonal arrangement of membrane attached particles between the Schwann cell and the axon of an autonomic nerve terminal was observed. Three types of contact areas between pineal cells are described. In the first two types, which occur more frequently, the diameter of the area varied from 1000 to 2500 Å, with irregularly aggregated membrane associated particles. The third type, larger but less frequently found, has a surface area of 0.4 μm2 and much more regularly distributed membrane associated particles (ø 88 Å). These contact areas can be considered to be electric coupling areas between pineal cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224264
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  • 89
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    Electronic Resource
    Junctions in the central nervous system of the cat (1974)
    Springer
    Cell & tissue research 148 (1974), S. 565-576 
    Details
    ISSN: 1432-0878
    Keywords: Central myelin ; Junctions ; Cat ; Freeze-etching ; Lanthanum impregnation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In male and female cats central myelin was studied using the freeze-etching technique, and after impregnation with lanthanum as a tracer. The freeze-fractured and etched faces of the myelin reveal membrane formations which in many respects resemble tight junctions. The formations consist of parallel rows of particles on one half of the membranes matched by corresponding furrows on the other membrane half. These structures occur across the width of the myelin sheath and are most common in that part of the myelin underlying the external cytoplasmic loop. They are interpreted as correlates of the radial component of the i-line which occurs in cross-sections of central myelin after potassium permanganate staining. In the paranodal zone the lanthanum-impregnated myelin displays punctate fusions between the outer leaflets of the oligodendrocytic membranes. These findings strongly suggest that tight junctions are a common feature in the central myelin. The arrangement of the membrane fusion in relation to the elements of the lamellar complex and their functional significance is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221940
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  • 90
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    Electronic Resource
    Indoleamine-containing nerve terminals in the rat median eminence (1974)
    Springer
    Cell & tissue research 147 (1974), S. 285-292 
    Details
    ISSN: 1432-0878
    Keywords: Median eminence ; Rat ; Serotonin terminals ; 5,6- and 5,7-Dihydroxytryptamine ; Chemical degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopical evidence for the existence of an important serotonergic input to the rat median eminence is presented. This evidence is based on the demonstration of degenerating nerve terminals in the external layer of the rat median eminence following the application of 5,6-dihydroxytryptamine or 5,7-dihydroxytryptamine, drugs known to exert more or less selective toxic effects on central serotonin neurons. The finding of a serotonergic innervation of the median eminence in mammals has important implications for 5-hydroxytryptamine as a modulator of synthesis and/or release of hypothalamic, hypophysiotropic hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582802
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  • 91
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    On the ultrastructure of the rat anococcygeus muscle (1974)
    Springer
    Cell & tissue research 149 (1974), S. 91-104 
    Details
    ISSN: 1432-0878
    Keywords: Anococcygeal muscle ; Smooth muscle ; Rat ; Innervation, adrenergic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The rat anococcygeus muscle, which is known from previous functional and histochemical investigations to be a smooth muscle with a dense adrenergic innervation, was studied by electron microscopic methods. The muscle was found to be organized in small bundles of 2 to 8 muscle cells, which were interconnected by desmosome-like junctions and by gap junctions. Small Schwann cell-axon complexes with 1 to 5 axons appeared to represent the functional terminal nerve pathway. Such axon complexes were located at the periphery of the small smooth muscle bundles, they never penetrated into them. A ratio of approximately 6 small axon complexes per 100 muscle cells was found. After glutaraldehyde fixation axon varicosities contained mainly small empty vesicles. After treatment with 5-hydroxydopamine and permanganate fixation mainly small vesicles with a dense core were found. The neuromuscular distances ranged from 550 to 5000 Å, with a mean of about 2600 Å. True close neuromuscular contacts at a distance below 500 Å with a fusing of basal laminae were absent. The present observations provide a morphological base for the findings of previous electrophysiological and pharmacological studies on the anococcygeal muscle.
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    URL: http://dx.doi.org/10.1007/BF00209052
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  • 92
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    Ultramorphometric studies regarding the effect of sex-hormones on the adrenal cortex of the rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 113-120 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Rat ; Sex-hormones ; Ultramorphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Ultramorphometrisch wurde nach dem Verfahren von Rohr et al. (1971) die äußere Zona fasciculata von Sprague-Dawley-Ratten bei 5 Gruppen zu je 4 Tieren verglichen: Männchen, Weibchen im Diöstrus, Weibchen im Östrus, männliche und weibliche Kastraten (Kastration am 4. Lebenstag). Die Nebennierenrindenzellen der äu\eren Fasciculata sind bei Weibchen gegenüber denen normaler Männchen hypertroph: Weibchen im Diöstrus zeigen gegenüber Männchen größere Einzelzellen mit vermehrtem glattem endoplasmatischem Reticulum, erhöhten Einzel- und Gesamtvolumina der Mitochondrien sowie einem höheren Lipoidgehalt bei stärkerer Dispersion der Liposomen. Dieselben funktionsspezifischen Strukturen nehmen bei den Weibchen im Östrus noch weiter zu. Die Kastration der Weibchen am 4. Lebenstag führt zu einer Reduktion der funktionsspezifischen morphometrischen Parameter unter die Werte der Diöstrus-Tiere. Männliche Kastraten gleichen die Werte ihrer funktionsspezifischen Strukturen weitgehend denen der Weibchen im Diöstrus an. Nach Kastration am 4. Lebenstag zeigen weibliche Tiere somit etwas niedrigere morphonietrische Parameter in der äußeren Zona fasciculata als die männlichen Kastraten.
    Notes: Summary With the method of Rohr et al. (1971) the outer zona fasciculata of Sprague-Dawley-rats was compared ultramorphometrically in 5 groups of 4 animals each: males, females during diestrus, females during estrus, male and female castrates (castration on 4th day of life). Adrenal cortical cells of the outer fasciculata in females are hypertrophic in comparison with those of normal males: females during diestrus show in comparison with males larger individual cells with increased SER, increased volume of the individual mitochondrium and total volume of mitochondria as well as an increased lipoid content together with a more pronounced dispersion of liposomes. The same function-specific structures show a further increase in females during estrus. Castration of females on the 4th day of life leads to a reduction of the function-specific morphometric parameters below the values of the diestrus animals. Male castrates show adaption of the values of their function-specific structures towards those of females during diestrus. Following castration on the 4th day of life, female animals thus show somewhat lower morphometric parameters in the outer zona fasciculata than male castrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209054
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  • 93
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    Electronic Resource
    The fine structure of adrenal zona glomerulosa in the adult rat (1974)
    Springer
    Cell & tissue research 149 (1974), S. 235-243 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal zona glomerulosa ; Rat ; Normal ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This paper reports on an electron microscopic study of the adrenal zona glomerulosa in the normal rat, with special emphasis on the structural diversity of mitochondria in its parenchymatous cells. The mitochondria of cristae may be tubulo-vesicular, plate-like and/or straight tubular, any one mitochondrion containing one or more types of cristae. The mitochondrial features of the zona glomerulosa parenchymatous cells are attributed to the biochemical stages of aldosterone synthesis, taking place in different mitochondria of these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222276
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  • 94
    Electronic Resource
    Electronic Resource
    Different populations of granules and their distribution in the hypothalamo-neurohypophysial tract of the rat under various experimental conditions (1974)
    Springer
    Cell & tissue research 151 (1974), S. 117-140 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamo-neurohypophysial system ; Rat ; Granule distribution ; Electron microscopy, morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die Neurohypophyse und die neurosekretorischen hypothalamischen Kerngebiete von normalen männlichen und weiblichen Ratten, von trächtigen und durstenden Tieren wurden elektronenmikroskopisch und morphometrisch mit der Fragestellung untersucht, ob sich in den Häufigkeitsverteilungen der mittleren Granula-Durchmesser, bezogen auf die Anzahl der Axone, eine zweigipflige Verteilung ergibt. Bei Kontrolltieren zeigen die Perikarya des Nucleus supraopticus zahlreichere und größere Granula als die Zellen des Nucleus paraventricularis, wobei der Unterschied in den Durchmessern der Granula bei den weiblichen Tieren ausgeprägter ist als bei den männlichen. Beide Kontrollgruppen zeigen in der Neurohypophyse ein zweigipfliges Verteilungsmuster der Granula, wobei die beiden Gipfel bei den männlichen Kontrollen dichter beieinander liegen als bei den weiblichen. Bei den trächtigen Tieren weisen beide Kerngebiete Zeichen gesteigerter Aktivität auf und die Granula in den Zellen des Nucleus paraventricularis sind deutlich größer als bei Kontrolltieren. Zu Beginn der Tragzeit werden relativ große, wahrscheinlich vasopressinhaltige Granula in der Neurohypophyse gespeichert, während sich im letzten Drittel der Tragezeit die beiden Populationen dort nicht mehr unterscheiden lassen. Nach 48 Std. Wasserentzug erscheinen beide hypothalamischen Kerne aktiviert. Auffallend ist, daß die Granula im Nucleus supraopticus deutlich kleiner sind als bei Kontrolltieren. Entsprechend fehlen in der Neurohypophyse große Granula, während Axone mit kleinen Granula vermehrt sind. Nach zehntägiger Durstperiode lassen sich im Nucleus supraopticus, neben sehr typischen morphologischen Veränderungen, morphometrisch ebenfalls deutlich kleinere Granula nachweisen. Im Hypophysenhinterlappen dieser Versuchsgruppe sind die granulahaltigen Axone sehr stark vermindert, und in der Häufigkeitsverteilung fehlen die Granula mit großem Durchmesser während der dem Oxytocin zugeordnete Gipfel unverändert erscheint. In Verbindung mit den elektronenmikroskopischen Befunden lassen sich also aus den Verschiebungen der Verteilungsmuster zwischen den sechs Versuchsgruppen die Granula mit kleinerem Durchmesser oxytocinhaltigen Axonen zuordnen und Granula mit größerem Durchmesser zu den Endigungen, die Vasopressin enthalten. Die morphometrischen Befunde in den neurosekretorischen hypothalamischen Kerngebieten bestätigen diese Zuordnung. Die elektronenmikroskopischen und morphometrischen Befunde werden besonders im Hinblick auf die Hormonverschiebungen zwischen dem “reserve pool” und den “easily releasable pool” diskutiert.
    Notes: Summary A morphometric evaluation of electron micrographs has been carried out from neurosecretory terminals in the neurohypophysis and from the supraoptic and paraventricular nuclei in normal male and female rats as well as in pregnant and water deprived rats. The task of this investigation was to find out whether frequency distribution diagrams of the mean diameter of the neurosecretory granules, plotted versus the number of axons, reveal a grossly bimodal distribution. In normal rats the nerve cells of the nucleus supraopticus (S.O.N.) show more numerous and larger granules than the cells of the nucleus paraventricularis (P.V.N), this difference with respect to the diameter being more pronounced in female than in male animals. In the posterior pituitary lobes the neurosecretory granules exhibit a bimodal distribution, the second peak being situated more closely to the first one in male controls. In pregnant animals both nuclei appear to be activated, and the granules of P.V.N. are distinctly larger as compared to those of female control animals. In early pregnancy larger, i.e. presumably vasopressin-containing granules are stored in the neurohypophysis, while in the last phase before delivery oxytocin-containing neurons and vasopressin-containing ones cannot be differentiated any more. After 48 hrs of thirst both hypothalamic nuclei exhibit signs of increased activation, the diameters of the granules in the S.O.N. being distinctly smaller than in normals. In the neurohypophysis granules with large diameters are lacking, while axons with small granules are more frequent. In the S.O.N. of animals, water deprived for 10 days the diameters of the granules are smaller than normal and in the neurohypophysis the number of granule-containing fibres is strongly reduced. In the frequency distribution diagram granules with larger diameters are lacking whereas the peak, attributed to oxytocin, is not essentially altered. However, from the observed alteration on the distribution patterns of the six experimental groups and in connection with the electron microscopic results the granules with smaller diameters can be attributed to oxytocin-containing axons and the larger ones to vasopressin-containing terminals. Analogous morphometric data have been obtained from the neurosecretory nuclei as well. The electron-microscopic and morphometric observations are discussed with regard to hormone-shifts between the reserve pool and the easily-releasable pool.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222039
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  • 95
    Electronic Resource
    Electronic Resource
    Studies on the juxtaglomerular apparatus (1974)
    Springer
    Cell & tissue research 151 (1974), S. 471-480 
    Details
    ISSN: 1432-0878
    Keywords: Juxtaglomerular apparatus ; Rat ; Influence of deoxycorticosterone (DOC) ; Electron microscopy ; Morphometric analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die quantitativ-morphologische Analyse des juxtaglomerulären Apparates nach DOC-Behandlung zeigte, daß mit der Hemmung der Reninbildung eine Hypoplasie der epitheloiden Zellen des juxtaglomerulären Apparates einhergeht. Der Granulagehalt der juxtaglomerulären Zellen nahm ab; die Kern-Plasma-Relation änderte sich und die Leiomyofibrillen in den Epitheloidzellen nahmen zu. An den übrigen Anteilen des juxtaglomerulären Apparates, insbesondere der Macula densa, wurden keine morphologischen Veränderungen beobachtet. Die DOC-Behandlung führte darüber hinaus zu einer Bildung von Einschlüssen in den Podocyten, den Mesangiumzellen und den Zellen der Bowman-Membran. Die verschiedenen Möglichkeiten, über welche Faktoren die juxtaglomerulären Zellen nach DOC-Behandlung degranuliert werden, werden diskutiert. Das ultrastrukturelle Bild der Epitheloidzellen nach DOC-Behandlung entspricht deutlich einer gehemmten Sekretion, da das Ergastoplasma und der Golgi-Apparat ganz besonders stark zurückgebildet werden.
    Notes: Summary Quantitative morphological analysis of the Juxtaglomerular apparatus of rats treated with deoxycorticosterone (DOC) and salt revealed hypoplasia of the epithelioid cells as a concomitant of the inhibition of renin synthesis. The granular content of the Juxtaglomerular cells was significantly decreased, while the nucleus-to-cytoplasm ratio and the volume density of leiomyofilaments in the epithelioid cells increased. No morphological alterations were observed in the remaining constituents of the Juxtaglomerular apparatus, including the macula densa. DOC-treatment also induced the appearance of inclusions in the podocytes in the cells of the mesangium, and in the cells of Bowman's capsule. The possible mechanisms of degranulation of the Juxtaglomerular cells after treatment with DOC are discussed. The ultrastructural appearance of the epithelioid cells after treatment with DOC corresponds to an inhibition of secretion, since the rough endoplasmic reticulum and the Golgi apparatus undergo marked regressive changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222992
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  • 96
    Electronic Resource
    Electronic Resource
    Hypothalamic projections to the amygdala in the cat (1974)
    Springer
    Cell & tissue research 151 (1974), S. 499-508 
    Details
    ISSN: 1432-0878
    Keywords: Limbic system ; Cat ; Amygdaloid body ; Hypothalamus ; Stereotaxic lesions ; Light and electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to determine the origin of the hypothalamo-amygdaloid connections in the cat, small lesions were placed at various rostro-caudal levels of the hypothalamus. The animals were sacrificed after a period of 4, 8 or 11 days and the brains stained with the Nauta (1957), Fink and Heimer (1967) or Wiitanen (1969) method for the demonstration of degenerating axons and their terminals. It was observed that the anterior hypothalamic nucleus sends a small projection to the medial subdivision of the central nucleus and to the basal and lateral nuclei of the amygdala. The lateral preoptic area sends a larger projection to the anterior amygdaloid area, both subdivisions of the central and basal nuclei, and to the lateral and medial nuclei. No degeneration was observed in the amygdala following lesions in the medial preoptic area, the ventromedial nucleus or the lateral hypothalamic area caudal to the anterior hypothalamic area. In a series of animals with lateral preoptic lesions, the site of termination of degenerating boutons on neurons of the amygdaloid nuclei was determined and the course of the degenerative process followed over a period ranging from 2 to 15 days. Many of the boutons, especially in the earlier stages of degeneration, appeared to be of the B3 type, containing flattened vesicles and forming symmetrical synaptic contacts with dendrites or somata. With longer post-operative survival times, however, they became increasingly electron dense and shrunken, so that the bouton type could not be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222995
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  • 97
    Electronic Resource
    Electronic Resource
    Einfluß der Splenektomie auf Magensaftsekretion und Ulcusentstehung der Ratte (1974)
    Springer
    Langenbeck's archives of surgery 336 (1974), S. 15-23 
    Details
    ISSN: 1435-2451
    Keywords: Rat ; Splenectomy ; Gastric Ulceration ; Increase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Ratten wurde der Einfluß von Splenektomie auf Magensaftsekretion und Ulcusentstehung untersucht. Sowohl nach “restraint-stress” als auch Pylorusligatur wiesen die splenektomierten Tiere eine ausgeprägte Steigerung der Ulcuszahl und -größe gegenüber den Kontrolltieren auf. In der Magensaftanalyse waren dagegen die Werte der splenektomierten Tiere gegenüber den scheinoperierten nur geringgradig gesteigert. — Als mögliche Ursache der vermehrten Ulcusanfälligkeit nach Splenektomie wurde eine Veränderung lokaler, nicht säuresekretorischer Faktoren der Magenwand diskutiert.
    Notes: Summary In Splenectomiced rats incidence of gastric ulceration was compaired with control groups. Restraint stress and ligation of pylorus was used as model. Splenectomiced rats do show an higher incidence in both models. Both frequency and extension of gastric ulcer were accumulated significantly. Analysis of gastric secretion was only unessentially raised in comparisom to control-groups. Change of protective factors of stomach as possible reason is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291870
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  • 98
    Electronic Resource
    Electronic Resource
    The contribution of solvent drag to the intestinal absorption of tritiated water and urea from the jejunum of the rat (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 133-152 
    Details
    ISSN: 1432-1912
    Keywords: Intestinal Absorption ; Tritiated Water ; Urea ; Solvent Drag ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Jejunal loops of anaesthetized rats were perfused with hypotonic, isotonic, and hypertonic buffered solutions containing tritiated water or 14C-labelled urea. The blood flow of the loop was maintained constant at an intermediate rate (0.8–0.9 ml min−1 g−1 wet tissue weight). The water net flux was determined by means of polyethylene glycol as nonabsorbable marker and amounted up to ±30 μl min−1 g−1 w. w. 2. A positive water net flux (directed towards the blood) increased the absorption rates (disappearance rate from the intestinal lumen, appearance rate in the intestinal venous blood) of tritiated water and urea by maximally 22 and 41%, a negative water net flux (directed towards the gut lumen) diminished it by 12 and 32%. 3. The data were analysed by means of a kinetic model with the water net flux as independent variable. The sieving coefficient ⧫=1-δ was 1.18±0.44 for tritiated water and 0.86±0.11 for urea at pH 6.2. The water net flux influenced the absorption of solutes by interaction within the membranes (solvent drag in a restricted sense) and by changing the volume of blood flowing in the capillaries near the epithelium. This last effect is large for the absorption of the rapidly absorbable tritiated water, but small for the absorption of urea which is absorbed ten-times slower. 4. The water net flux in the intestine depended linearly on the osmotic pressure difference between lumen and blood. The hydraulic permeability was 146–180 ml2 min−1 g−1 osm−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503979
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  • 99
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    Electronic Resource
    The influence of blood flow on the absorption of l- and d-phenylalanine from the jejunum of the rat (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 113-138 
    Details
    ISSN: 1432-1912
    Keywords: Intestinal Blood Flow ; Intestinal Absorption ; l- and d-phenylalanine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Jejunal loops of anaesthetized rats were perfused (single pass and recirculation) with buffered solutions containing l-phenylalanine (about 30 μM and 30 mM) and d-phenylalanine (about 30 μM). The blood flow, the disappearance rate (from the intestinal lumen) and the appearance rate (in the intestinal venous blood) were determined simultaneously, the accumulation in the gut wall at the end of the experiments. 2. At a constant intermediate blood flow the absorption of l- and d-phenylalanine decreased with time. A decrease of blood flow from about 1.6 to 0.25 ml min−1g−1 wet tissue weight diminished the appearance and the disappearance rate of both isomers. An increase of blood flow from 0.25 to 1.6 ml min−1g−1 caused no increase of absorption; on the contrary the appearance and disappearance rate decreased a little. The different dependence of absorption when decreasing and increasing the blood flow rate may be caused by a changed pattern of blood flow in the layers of the gut wall, i.e. the flow rate in the villi may be reduced while the flow rate in the entire wall remains unchanged. 3. In the single pass perfusion experiments the appearance rate of l-phenylalanine increased proportionally to the luminal concentration (30 μM and 30 mM), while the accumulation was relatively smaller at the high concentration. In the recirculation experiments the appearance rate and the accumulation of l-phenylalanine did not increase proportionally. 4. The increase in perfusion rate, from 0.1 (single pass perfusion) to 2–3 and 10 ml min−1 (recirculation), caused an increase of l-phenylalanine absorption and tissue accumulation. 5. At a luminal concentration of about 30 μM the appearance rates of l- and d-phenylalanine were equal, while the tissue accumulation was smaller for the d-isomer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501154
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  • 100
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Bildung gemischter Disulfide zwischen D-Penicillamin und Serumproteinen (1973)
    Springer
    Research in experimental medicine 161 (1973), S. 289-297 
    Details
    ISSN: 1433-8580
    Keywords: D-penicillamine ; L-cysteine ; Serum proteins ; Rat ; D-Penicillamin ; L-Cystein ; Serumproteine ; Ratte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In vitro-Untersuchungen zeigten, daß D-Penicillamin durch Serumproteine, in erster Linie durch Albumin, gebunden wird. Aller Wahrscheinlichkeit nach ist die Bildung gemischter Disulfide hierfür verantwortlich. Cystin, L-Cystein und andere Thiole sowie N-Äthylmaleinimid hemmen die Proteinbindung von D-Penicillamin. Verabfolgt man Ratten vor Injektion des D-Penicillamins L-Cystein, resultiert eine vorübergehende Erhöhung des Gehalts an freiem D-Penicillamin in Serum und in einigen Geweben, während die Ausscheidung mit dem Urin verzögert wird. Die theoretische und praktische Bedeutung der Befunde wird diskutiert.
    Notes: Summary Studiesin vitro show that D-penicillamine is bound by serum proteins, mainly albumin; the formation of a mixed disulfide is the most likely explanation. Cystine, L-cysteine and other thiols as well as N-ethylmaleinimide were found to inhibit the protein binding of D-penicillamine. Administration of L-cysteine to rats prior to D-penicillamine brings about a transient increase of the amount of free D-penicillamine in serum and in some tissues as well as a delay in its urinary excretion. The theoretical and practical implications of the findings are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851452
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